Nanoscale vaults encapsulate nanodisks for drug delivery

The development of new methods that use engineered nanomaterials to transport drugs and release them directly into cells holds great potential in this area. And while several such drug-delivery systems have won approval for clinical use, they have been hampered by size limitations and ineffectiveness in accurately targeting tissues. Now, researchers at UCLA have developed a new and potentially far more effective means of targeted drug delivery using nanotechnology.

Researchers construct RNA nanoparticles to safely deliver long-lasting therapy to cells

Nanotechnology researchers have known for years that RNA, the cousin of DNA, is a promising tool for nanotherapy, in which therapeutic agents can be delivered inside the body via nanoparticles. But the difficulties of producing long-lasting, therapeutic RNA that remains stable and non-toxic while entering targeted cells have posed challenges for their progress. Now, researchers detail successful methods of producing large RNA nanoparticles and testing their safety in the delivery of therapeutics to targeted cells.

Complex 3D-nano patterns with indentation lithography and piezo technology

A collaboration between the Whitesides Group at Harvard University and CSM Instruments has culminated in an important advance in lithography of different materials at the nanoscale. The motivation for this development was the ability to produce unique lithographical patterns of different shapes and sizes for use in research applications (e.g. lab-on-a-chip) where conventional techniques such as electron-beam lithography (EBL) and photolithography cannot be used.

Researchers now one step closer to controlled engineering of nanocatalysts

Yu Huang, an assistant professor of materials science and engineering at the UCLA Henry Samueli School of Engineering and Applied Science, and her research team have proposed and demonstrated a new approach to producing nanocrystals with predictable shapes by utilizing surfactants, biomolecules that can bind selectively to certain facets of the crystals' exposed surfaces.

Catching cancer with carbon nanotubes

A multidisciplinary team of investigators at Harvard and MIT have created a new device that can detect single cancer cells in a blood sample, potentially allowing doctors to quickly determine whether cancer has spread from its original site. The microfluidic device is about the size of a dime, and could also detect cancer-causing viruses such as hepatitis B and C and the human papilloma virus.

Nanoscale approaches to designing contrast agents for cancer detection

The effectiveness of optical imaging processes can be significantly improved with suitable dyes used as contrast agents. Now, researchers have introduced a novel contrast agent that marks tumor cells in vitro. The dye is a phosphorescent ruthenium complex incorporated into nanoparticles of a metal-organic coordination polymer, which allows an extraordinarily high level of dye loading.

Tiny gems take big step in battling cancer

Chemotherapy drug resistance contributes to treatment failure in more than 90 percent of metastatic cancers. Overcoming this hurdle would significantly improve cancer survival rates. Dean Ho, of Northwestern University, believes a tiny carbon particle called a nanodiamond may offer an effective drug delivery solution for hard-to-treat cancers.