How Star Trek Helped Predict (and Design) the iPad

How Star Trek artists imagined the iPad... 23 years ago, Ars Technica

"To understand the thinking that led to the design of the Star Trek PADD, we spoke to some of the people involved in production of ST:TNG (as well as other Star Trek TV series and films), including Michael Okuda, Denise Okuda, and Doug Drexler. All three were involved in various aspects of production art for Star Trek properties, including graphic design, set design, prop design, visual effects, art direction, and more. We also discussed their impressions of the iPad and how eerily similar it is to their vision of 24th century technology, how science fiction often influences technology, and what they believe is the future of human-machine interaction."

Follow-up to “An unfortunate case”

Thanks to the readers who responded with the correct diagnosis to last week’s case!  I’ve also presented this case at our weekly clinical pathology conference and I’ve found it extremely interesting and educational.

This was indeed a case of hepatosplenic T-cell lymphoma (HSTL), gamma-delta type.  Characteristically, lymphadenopathy was absent and there was no peripheral involvement at presentation.  Interestingly, however, the typical intrasinusoidal marrow involvement was a minor feature second to an interstitial process.  Perhaps it was just caught at a progressed stage.  The immunophenotype was fairly typical: CD2+, surface CD3+, CD4-, CD5-, CD7 partial dim, CD8 partial dim, CD16+, and CD56/CD57-.  One reader pointed out that these lymphomas are usually CD4- and CD8-.  This is true; but a solid subset will express partial CD8+ as this case did.  Another interesting feature of this T-cell lymphoma is its predilection for expression of multiple KIR isoforms, for those of you keen on flow cytometry.  Cytogenetic studies also showed the characteristic isochromosome 7q and associated trisomy 8.  The spleen was also removed after diagnosis and representative images are shown below.

While it was more specifically named hepatosplenic gamma-delta T-cell lymphoma in the REAL classification, the WHO 2001 and 2008 classification calls this entity simply hepatosplenic T-cell lymphoma, as alpha-beta rearranged TCRs are found in a minority of cases.  From my perspective, the main differential diagnoses here are:

1) gamma-delta T-large granular lymphocytic leukemia: often a very difficult distinction to make, though g-d T-LGLLs are quite rare (alpha-beta T-LGLs much more common).  From my reading, T-LGLLs will often express some CD5 and/or CD57 (rather than CD56 in many HSTLs) and have the activated cytotoxic phenotype of TIA-1+, granzyme B+, and perforin+ by IHC.  HSTLs would be TIA-1+ but granzyme M positive rather than granzyme B.  Also, the isochromosome 7q/trisomy 8 associations are not classic for T-LGLLs.  Probably most importantly, though, is the clinical picture: T-LGLLs will be relatively indolent and involve the peripheral blood.

2) peripheral T-cell lymphoma (NOS): if classical HSTL features are not present

3) aggressive NK cell leukemia/lymphoma: Asian females, EBV-associated, surface CD3 neg by flow cytometry

I suppose in some respects an adult T-cell leukemia/lymphoma might also be on the differential but one would need a different clinical and immunophenotypic picture (patient from Caribbean, Japan, or Africa; positive HTLV-1 status; more atypical lymphocytes [flower cells], CD4+, CD7-, CD8-, CD25(strong+), CD26+.

Another important aspect to point out with regard to hepatosplenic T-cell lymphomas is their association with chronic immune suppression and/or antigenic stimulation.  The entity is also one type of post-transplant lymphoproliferative disorder (PTLD) – but of T cells.  Patients with inflammatory bowel disease or following renal transplantation are especially at risk for this complication, especially those treated with the TNF-alpha blocking agents and immune suppressing drugs like infliximab and azathioprine, respectively.

In Dr Foucar’s 3rd edition of Bone Marrow Pathology – a must-read – it is also emphasized that HSTLs may also present with an exuberant myelomonocytic proliferation, sometimes mimicking a chronic or juvenile myelomonocytic leukemia (CMML or JMML, respectively).

While there is much more to be said of gamma-delta T cells, my space is limited!  Suffice it to say, they are a minor subset of circulating and epithelial T cells involved in the innate immune response and the normal counterpart of primary cutaneous gamma-delta T-cell lymphomas, the other relatively well-described site for these cells to go mad.

Unfortunately for this patient, hepatosplenic T-cell lymphomas are very aggressive and median survival is <2 yrs.  It is ultimately difficult to reach allogeneic stem cell transplant and none of the standard chemotherapeutic regimens work well for the disease.  Early splenectomy, novel antifolates, cladribine, and monoclonal antibodies (including anti-CD52) have been employed with some effect but the optimal therapy is still years away at best.  The post-solid organ transplant cases have a particularly dismal outlook and unlike other PTLDs immunosuppression these agents cannot simply be withdrawn.  These patients are treated with HyperCVAD and other extremely intensive chemotherapeutic regimens for any hope of survival.

Hope this was helpful!  Below are some helpful references…I highly recommend the Tripodo review from Nature Reviews Clinical Oncology.  And just for completeness, I have no financial disclosures regarding this case.

Belhadj K et al. Hepatosplenic T-cell lymphoma is a rare clincopathologic entity with poor outcome: report on a series of 21 patients. Blood 2003;102(13):4261-9.

Jaeger et al. Hepatosplenic gammadelta T-cell lymphoma successfully treated with a combination of alemtuzumab and cladribine. Ann Onc 2008; 19(5):1025-6.

O’Conner OA et al.  Pralatrexate, a novel class of antifol with high affinity for the reduced folate carrier-type 1, produces marked complete and durable remissions in a diversity of chemotherapy refractory cases of T-cell lymphoma. BJH 2007;139:425-8.

Tey SK et al. Post-transplant hepatosplenic T-cell lymphoma successfully treated with HyperCVAD regimen. Am J Hemat 2008;83:330-3.

Tripodo C et al. Gamma-delta T-cell lymphomas. Nat Rev Clin Oncol 2009;6:707-717.

Vega F, LJ Medeiros, and P Gaulard. Hepatosplenic and Other ?? T-Cell Lymphomas. AJCP 2007;127:869-80.

Slime-a-palooza! | The Loom

Caught hagfish440I’ve been waiting a long time to see a hagfish in person. Last year I took a class miles out to sea, hauled up traps from 300 feet, and came up with nothing but mud. Today, however, we discovered not just one hagfish–but fifty. Buckets full of squirming jawless beasts that seemed to slither straight out of the Cambrian Period. Their slime is more like a jelly made of glass–a marvelous thing. I am here to declare that a day with fifty hagfish is a good day.

(For more, read “Secrets of the Slime Hag” (pdf)” in Scientific American by Frederic Martini)

[Image courtesy of Charlotte Zimmer, age 9]


Erler: There’s no point in worrying about immortality

Alexandre Erler, in his essay "Is there any point in worrying about the tedium of immortality?," rightly concludes that we should not regard this supposed threat as having "any serious normative implications for the use and development of life extension technologies." Erler writes,

As for those who might share Walsh’s view and enjoy their life more due to the awareness of their own mortality, they might still preserve that benefit by committing themselves not to use life extension technologies when these become widely available. Of course, when the time to kick the bucket seemed near, they might find themselves unable to respect their previous commitment. But they might perhaps protect themselves from such a hazard by writing advance directives stipulating that life extension procedures should not be made available to them. Or if this were not possible, they could at least publicly declare their resolution not to use such procedures, so as to make it embarrassing for themselves if they failed to meet it. However that may be, the risk that some people might prevent themselves, by their own weakness of the will, to die when they would ideally have wanted to, does not seem a sufficient reason to deprive other people of the benefits of a radically extended lifespan. Pace Temkin, I would conjecture that many of us would welcome greater opportunities to learn everything that we find worth learning, to accomplish more things, and to spend more time with our loved ones. Some have also suggested that future humans might become able to experience goods that we cannot even think of today.

Link.

4 Messages a Pantomiming Orangutan Might Be Trying to Convey | 80beats

orangutanStop patting yourself on the back. You’re not so special. Orangutans, a new study suggests, also use complex gestures or pantomimes to communicate.

Looking through twenty years worth of orangutan observations, researchers believe they have found 18 examples of pantomimes. The study, which appeared today in Biology Letters, supports the claim that we’re not unique when it comes to abstract communication and lends credence to other observations of great ape gesturing, according to lead researcher Anne Russon.

[Orangutans and chimpanzees were already known] to throw an object when angry, for example. But that is a far cry from displaying actions that are intentionally symbolic and referential–the behaviour known as pantomiming. “Pantomime is considered uniquely human,” says Anne Russon from York University in Toronto, Canada. “It is based on imitation, recreating behaviours you have seen somewhere else, which can be considered complex and beyond the grasp of most non-human species.” [New Scientist]

Of the eighteen observed orangutan pantomimes, four took place between orangutans and 14 between a human and an orangutan. If you ever find yourself in the Indonesian jungles, here are some examples of messages that you might expect:

Lies

Orangutans can lie, it appears, pretending to engage in one activity while plotting another.

In some recordings, orangutans used gestures to distract or mislead others. One animal indicated to researchers that it wanted a haircut, as a ruse to divert their attention while it stole something, according to the study. [The Gaurdian]

Pity

Along that line, orangutans sometimes appeared to feign helplessness, as seen in this video in which a skilled coconut-opening orangutan pretends to be unable so that a human will do it for her.

The researchers jokingly call this sort of behavior “poor me,” referring to how the crafty apes feign weakness to get others to help. When Siti “failed,” she handed the coconut to a human staff member, along with the stick. She then pretended to use the stick as a machete, reenacting how she’d seen this person opening coconuts with machetes. He got the picture and opened the coconut with a machete while Siti impatiently waited with arms folded. [Discovery News]

Gratitude

Researchers believe that that the orangutans can also pantomime stories to reminisce. They cite a case of an orangutan with a foot injury named Kikan. A week after a conservationist pulled a small stone from the animal’s foot and used latex from a fig leaf to seal the wound, Kikan hugged the conservationist and re-enacted the foot first-aid. Says Russon:

“She’s not asking for anything, which is the most common aim observed of great ape communication, but appears simply to be sharing a memory with the person who helped her when she hurt her foot. It shows her understanding of how events had unfolded in a particular situation, which was very complex.” [BBC]

Good Hygiene

The orangutans observed in this exploratory study had once been in captivity but were then released into the forest. One orangutan seemed to remember face-scrubbings at a rehabilitation facility on Borneo.

[Russon says] she did know what was going on when a young male called Cecep plopped down in front of her and handed her a leaf. “I played dumb,” she remembers. “He waited a respectable few seconds, then–all the while looking me in the eye–he took back the leaf, rubbed it on his own forehead….” Again he handed it to her. “Then I did as I was told,” she says, and wiped away the dirt. [Science News]

Related content:
80beats: An Active Orangutan Burns Fewer Calories Than a Lazy Human
80beats: Study: Orangutans Play Leaf Instruments to Fool Predators
80beats: Syncopated Rhythm Makes Orangutans Masterful Swingers
80beats: Happy News: New Population of Endangered Orangutans Found in Borneo
80beats: Orangutans Are Threatened With Extinction as Habitat Shrinks

Image: Wikimedia / Malene Thyssen


Cancellation of Steam Boiler Tests

Could you please give me your views on the cancellation of daily steam boiler tests.

I am working in a hospital running 2 steam boilers that are unmanned. The steam that they produce is used for the sterilisers. It is a legal requirement that they should be tested every day. and the types of te

Siemens Master Drive

We experience some problems with a siemens 2000 Kw master drive:F025

We found a cable with the red phase down to earth. The cable was repaired but still the drive trips on F025

Is PWHT a Good Idea?

We are welding a thin wall (0.048") bushing to 1/8" thick material, both are 304 Stainless Steel using TIG with the appropriate rod. The weld is thee pretty good sized tacks. Would a post weld heating be recommended to prevent cracking? If so, at what temperature and how long?

Thanks,

Prosecutor to 4Chan Founder: Please Explain the Meaning of “Rickroll” | Discoblog

pooleWhen a Tennessee man hacked Sarah Palin’s e-mail account and wrote of his exploits on the forum 4chan, federal investigators asked the site’s founder Christopher “Moot” Poole for server logs. Court testimony from April and published yesterday shows that federal prosecutors had other pressing questions for Poole: for example, the meaning of “peeps” and “rickroll.”

Assistant to the U.S. Attorney Mark Krotoski questions Poole:

Q. Certain terms, have a meaning unique to 4chan?
A. Yes.

Q. Like “OP,” what is “OP”?
A. OP means original poster.

Q. Are you familiar these terms, having been the founder and administrator of the 4chan site?
A. Yes.

Q. What would “lurker” mean?
A. Somebody who browses but does not post, does not contribute.

Q. What do the words “caps” mean?
A. Screenshots.

Q. And is there any significance to “new fags”?
A. That is the term used to describe new users to the site.

Q. What about “b tard”?
A. It’s a term that users of the /b/- Random board use for themselves.

Q. What about “troll”?
A. Troublemaker.

Q. “404″?
A. 404 is the status code for not found. It means essentially gone or not found.

Q. Not found on where, the 4chan site?
A. 404 is the http status code for not found, a page not found by the Web server.

Q. In what about “peeps”?
A. People.

Q. “Rickroll”?
A. Rickroll is a mean [sic] or Internet kind of trend that started on 4chan where users — it basically a bait and switch. Users link you to a video of Rick Astley performing Never Gonna Give You Up.

Bonus humor points for the fact that the court reporter had apparently never heard the word “meme” before. The story went viral yesterday; we found it on Gawker’s Valleywag and the complete testimony on The Smoking Gun. Apologies to those hoping to find a reference to LOLcats: relevancy?

Check out DISCOVER on Facebook.

Related content:
Bad Astronomy: Sucked into a black LOL
Discoblog: Your Plants Have More Twitter Followers Than You—Literally
Discoblog: ZOMG! Get These iPhone Apps Right Meow!
Discoblog: Should the Internet Win the 2010 Nobel Peace Prize?

Image: flickr /Andrew Dupont


Lucy’s Species May Have Used Stone Tools 3.4 Million Years Ago | 80beats

DikikaWas Lucy a tool user and a meat eater?

Quite possibly, argues a new study in Nature. Archaeologist Shannon McPherron turned up animal bones at an Ethiopian site that he says show markings of stone tool cutting dating back nearly 3.4 million years. That would be a big jump in the record: Right now the oldest known evidence of tool use among our ancestral species dates back about 2.6 million years.

McPherron’s date falls in the time of Australopithecus afarensis, the species to which the famous Lucy find belongs. But thus far he’s found only the markings on bones—not the tools themselves. Perhaps not surprisingly, though, at least one scientist behind the 2.6 million-year-old find says the new study is not convincing evidence that tool use dates back all the way to 3.4 million years ago.

For plenty more about the find—and the differing opinions—check out DISCOVER blogger Ed Yong’s post.

Related Content:
Not Exactly Rocket Science: Human Ancestors Carved Meat with Stone Tools Almost a Million Years Earlier Than Expected
80beats: Lucy’s New Relative, “Big Man,” May Push Back the Origin of Walking
DISCOVER: How Loyal Was Lucy?

Image: Dikika Research Project


NASA/ISA MOU Signed

NASA and Israel Space Agency Sign Statement of Intent for Future Cooperation

"During a meeting Tuesday at NASA Headquarters in Washington, NASA Administrator Charles Bolden and Israel Space Agency Director General Zvi Kaplan signed a joint statement of intent to expand the agencies' cooperation in civil space activities. The signing followed a meeting between Bolden, Kaplan and Professor Daniel Hershkowitz, Israel's minister of Science and Technology. It advanced discussions that began when Bolden visited Israel in January."

Smart (and Stupid) Metering | The Intersection

AC MeterSo I’ve recently moved to Washington, D.C., and into a newish building. And I’ve been getting a utility bill with a rather large number being charged (on the order of $ 75 per month) for something called “HVAC,” or, heating, ventilation and air conditioning.

My inquiries into what this charge is for, and whether I can do anything to avoid it, speak volumes about the inefficiencies of our current energy system.

Turns out HVAC is calculated in the following way. There’s a total HVAC value for the building, and then an algorithm is used to apportion a supposedly fair fraction of the bill to each resident. The algorithm centrally takes into account 1) square footage of your apartment unit; 2) number of occupants. All of this is carried out by a sub-metering company, which then sends you the bill.

Let me acknowledge at the outset that I have no idea why things are set up this way–whether it is the choice of my building, or of some utility, or some other possibility. So I’m not laying blame. But I am interpreting the consequences of the arrangement–because as far as I can tell, the consequences are that there is absolutely no incentive for anybody in the building to save energy.

In fact, the incentive is probably the opposite–to blast cold air all the time. After all, you’re not really paying for it–your neighbors are.

In my case, I have a unit that gets no direct sunlight, so that even in this hot DC summer, the temperature remains about 75 degrees on average. Mostly, that’s fine with me, and I rarely use A/C. Furthermore, I travel a lot, and I turn everything off before I leave. So there will be a week or more at a time when there is no air conditioning at all being used in the apartment.

Up until now, then, I’ve been acting as a conscientious energy saver–a perfect little tree hugger. Up until now, I knew nothing about this HVAC business, or that my greenish behavior would have little to no effect on a key component of my energy bill.

But now that I do know, the question becomes, why be green? Heck, I’m tempted to start cranking the A/C. Everybody else in the building is, apparently. I’m no economist, but doesn’t this sound a bit like the tragedy of the commons scenario?

In fairness, I probably get a little bit of cooling from the A/C use of the other apartments, even if my A/C remains turned off. That’s probably worth taking into account. And maybe I’ll want more HVAC in the winter than I do in the summer, due to my lack of sunlight (though I doubt it).

Still, I don’t think these considerations outweigh the fundamental inefficiency and perverse incentives of this situation.

Now multiply my experience by the number of people living in buildings employing a similar sub-metering scenario (I have no idea how many there are, but somebody out there does). My guess is that you will end up with a very large inefficiency and dysfunctionality in our energy economy–a lot of waste, and a lot of discouragement of energy conserving behavior.

Smart metering, anyone?


Human ancestors carved meat with stone tools almost a million years earlier than expected | Not Exactly Rocket Science

Bone_scars

Every time we slice into a steak or cut into some chicken, we’re taking part in a technological heritage that stretches back at least 3.4 million years. Back then, the only cutting implements around were sharp pieces of stone and there were no true humans around to wield them. But there were still butchers– one of our ancestral species, Australopithecus afarensis, was already using stone tools to flay meat off bones, leaving small nicks with every cut. Such marked bones have been found and they push back the earliest estimates of tool use among human ancestors by 800,000 years.

In January 2009, a team led by Shannon McPherron from the Max Planck Institute found bones which had clearly been worked over with stone tools. The bones, uncovered in Dikika, Ethiopia, include the rib of a cow-sized animal and the thighbone of a goat-sized one. Both bore cuts and scratches inflicted by sharp objects and dents produced by crushing hammers.

By peering at the marks under powerful microscopes and analysing their chemical composition, McPherron confirmed that they were made by stone rather than teeth, and they were created before the bones fossilised. These were not accidental scratches, but the remnants of strikes used to carve off the meat and break into the marrow.

Based on the surrounding rock layers, which have been very accurately dated, McPherron calculated that the bones are at least 3.39 million years old. These relics push back both the history of butchery and the use of stone tools by human ancestors, by almost a million years. Until now, the oldest evidence for the manufacture of stone tools comes from finds in Gona, Ethiopia that are just 2.6 million years old, while the oldest cut-marked bones were found in nearby Bouri and dated to around 2.5 million years ago.

The Dikika site has been thoroughly studied by a team led by Zeresenay Alemseged (photo below), who also had a hand in the latest discovery. In fact, the new bones were found just 200 metres away from Alemseged’s most famous find – the bones of a three-year-old Australopithecus afarensis girl, known as Selam. No other hominin (a term for members of the human lineage) lived in the same area. This provides strong evidence that A.afarensis , such as the famous Lucy, used stone tools and ate meat. Selam may even have watched or helped as her family members carved up the carcass of a large animal.

In a way, this isn’t surprising. Recent discoveries have done much to strip A.afarensis of its early reputation as a primitive hominin and even other primates like chimpanzees use stone tools. McPherron says, “A. afarensis had a similar sized brain and perhaps somewhat better hands for the job, at some level it is not surprising that A. afarensis should use stone tools. However, we can’t assume that simply because chimps use stone tools and we use tools that the behaviour is as old as our common ancestor.”

Nonetheless, both tool use and meat-eating are critically important events in human evolution. “Some have argued that meat consumption is what set us down the path towards the large brained, behaviorally complex species that we are today,” says McPherron. “It has been said that meat made us human. It provides a more nutrient rich diet that made possible a larger brain.”

The use of tools also gave our ancestors access to rich sources of meat, namely the carcasses of large, dead animals. Most other primates would turn their noses up at such foods but it’s clear that A.afarensis did not. Indeed, the costs of eating such carcasses, such as competition with predators, may have driven the use of more sophisticated tools and close teamwork.

For now, McPherron hasn’t actually found any of the actual cutting tools or, in fact, any sharp-edged stones nearby. That’s to be expected – the area where the bones were found used to be part of the floodplain of a river and probably didn’t contain any stones larger than fine gravel. The nearest suitable materials were around 6 kilometres away. “If the stone tool had been made elsewhere and carried to this spot, as it almost certainly was, the odds of us finding it would be small even if they dropped it there,” says McPherron.

There is, of course, another explanation: McPherron’s team could be wrong. Sileshi Senaw, who discovered the Gona tools, certainly thinks so and says that the data just aren’t strong enough to support their conclusions. The Dikika researchers are making a huge claim based on very meager data,” he says.Researchers who study bone surface modifications from archeological sites have shown that fresh bones trampled by animals can create marks that mimic stone tool cut marks… I am not convinced of the new discovery.”

But McPherron stands by his interpretation and has other explanations: the butchers might just have picked up naturally sharp rocks from their surroundings; they could have made them so infrequently that they’ll be hard to find; or, simply, no one has looked hard enough. “I favor a combination of the last two,” he says.

Alison Brooks from George Washington University agrees. She thinks the sudden appearance of stone tools in the archaeological record, some 2.6 million years ago, doesn’t represent the point where early humans started using them, but the point where they started making them at concentrated sites where they’re more likely to be found. There was a long time window before that when stone tools were used in a more scattered way, a window that McPherron’s team have been lucky enough to look through.

McPherron plans to return to Dikika in January 2011 for a more intensive search. “There’s a location nearby where raw materials for stone tool production may have been available 3.4 [million years ago], and I hope to target this area to see if we can find evidence of stone tool manufacture.”

Zeresenay-Alemseged

Reference: Nature http://dx.doi.org/10.1038/nature09248

Images by the Dikika Research Project

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