Monthly Archives: June 2010

International Stem Cell Corporation Announces Company Update Conference Call. ISCO Chairman Kenneth Aldrich to Discuss 'Status of the Company'

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International Stem Cell Corporation (OTCBB:ISCO), a California-based biotechnology company creating human stem cell lines through its patented parthenogenetic process that requires no use of fertilized embryos, today announced that it is has scheduled a conference call for June 15, 2010 at 10:00 a.m. PST. ISCO Chairman, Mr. Kenneth Aldrich will discuss the Company's newly issued patent, its recently completed financing, and the present status of the company and its vision for the coming year. The dial-in number for participants is 1 (800) 774-6070 and the pass code ID is 8273 225#. An alternate dial-in number is: 1 (630) 691-2753 and the pass code will be the same for both numbers. A replay of the call will be available on the home page of the company's web site at: http://www.internationalstemcell.com.

ABOUT INTERNATIONAL STEM CELL CORPORATION (ISCO.OB)

International Stem Cell Corporation is a California-based biotechnology company focused on therapeutic and research products. ISCO's core technology, parthenogenesis, results in creation of pluripotent human stem cells (hpSCs) from unfertilized oocytes (eggs). hpSCs avoid ethical issues associated with the use or destruction of viable human embryos. ISCO scientists have created the first parthenogenic, homozygous stem cell line that can be a source of therapeutic cells with minimal immune rejection after transplantation into hundreds of millions of individuals of differing sexes, ages and racial groups. This offers the potential to create the first true stem cell bank, UniStemCellTM, while avoiding the ethical issue of using fertilized eggs. ISCO also produces and markets specialized cells and growth media for therapeutic research worldwide through its subsidiary Lifeline Cell Technology. More information is available at ISCO's website, http://www.internationalstemcell.com.

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FORWARD-LOOKING STATEMENTS:

Statements pertaining to anticipated technological developments and therapeutic applications, and other opportunities for the company and its subsidiary, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as "will," "believes," "plans," "anticipates," "expects," "estimates,") should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in the development and/or commercialization of potential products, uncertainty in the results of clinical trials or regulatory approvals, need and ability to obtain future capital, application of capital resources among competing uses, and maintenance of intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the company's business, particularly those mentioned in the cautionary statements found in the company's Securities and Exchange Commission filings. The company disclaims any intent or obligation to update these forward-looking statements.

International Stem Cell Corporation
Kenneth C. Aldrich, Chairman
760-940-6383
kaldrich@intlstemcell.com
or
Brian Lundstrom, President
760-640-6383
bl@intlstemcell.com

Enzymatic digestibility and ethanol fermentability of AFEX-treated starch-rich lignocellulosics such as corn silage and whole corn plant

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Background:
Corn grain is an important renewable source for bioethanol production in the USA. Corn ethanol is currently produced by steam liquefaction of starch-rich grains followed by enzymatic saccharification and fermentation. Corn stover (the non-grain parts of the plant) is a potential feedstock to produce cellulosic ethanol in second-generation biorefineries. At present, corn grain is harvested by removing the grain from the living plant while leaving the stover behind on the field. Alternatively, whole corn plants can be harvested to cohydrolyze both starch and cellulose after a suitable thermochemical pretreatment to produce fermentable monomeric sugars. In this study, we used physiologically immature corn silage (CS) and matured whole corn plants (WCP) as feedstocks to produce ethanol using ammonia fiber expansion (AFEX) pretreatment followed by enzymatic hydrolysis (at low enzyme loadings) and cofermentation (for both glucose and xylose) using a cellulase-amylase-based cocktail and a recombinant Saccharomyces cerevisiae 424A (LNH-ST) strain, respectively. The effect on hydrolysis yields of AFEX pretreatment conditions and a starch/cellulose-degrading enzyme addition sequence for both substrates was also studied.
Results:
AFEX-pretreated starch-rich substrates (for example, corn grain, soluble starch) had a 1.5-3-fold higher enzymatic hydrolysis yield compared with the untreated substrates. Sequential addition of cellulases after hydrolysis of starch within WCP resulted in 15-20% higher hydrolysis yield compared with simultaneous addition of hydrolytic enzymes. AFEX-pretreated CS gave 70% glucan conversion after 72 h of hydrolysis for 6% glucan loading (at 8 mg total enzyme loading per gram glucan). Microbial inoculation of CS before ensilation yielded a 10-15% lower glucose hydrolysis yield for the pretreated substrate, due to loss in starch content. Ethanol fermentation of AFEX-treated (at 6% w/w glucan loading) CS hydrolyzate (resulting in 28 g/L ethanol at 93% metabolic yield) and WCP (resulting in 30 g/L ethanol at 89% metabolic yield) is reported in this work.
Conclusions:
The current results indicate the feasibility of co-utilization of whole plants (that is, starchy grains plus cellulosic residues) using an ammonia-based (AFEX) pretreatment to increase bioethanol yield and reduce overall production cost.

Gaia Herbs achieves industry breakthrough in herb potency, safety and traceability

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I'm a big fan of herbal products, but have you ever wondered whether the ingredients that are supposed to be in those products are actually present in their correct potency? Did you ever wonder where the herbs really came from?

As you'll discover here, one company has suddenly and dramatically changed the entire medicinal herbs landscape by offering consumers a kind of X-Ray vision (without the X-Rays) into the potency, origin and safety of the exact herbs that are inside each bottle.

This innovation is called "Meet Your Herbs," and I first became aware of it at a recent natural products expo in California where I happened to catch a glimpse of someone carrying a bag emblazed with the slogan. The "Meet Your Herbs" phrase made instant sense to me because I've been living in Ecuador for the last two years where I've finally been able to grow and meet many of the medicinal herbs I used to buy solely as finished product. Read more...

ClariMind Memory & Concentration Supplement

The Jungle island of Monkeys and man eating lizards.

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Ok so man eating lizards is a slight exaggeration.. i do not know for sure if the lizardiguanabeast thing reaching to the size of about 4ft would actually eat humans.. but all i know is i did not stick around to see if it couldSo the island Tioman is where we spent our last couple of days. I was so surreal. I felt like i was in the tv series lost. There is jungle and i mean thick thick green

iseltwald

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ok so at the lake lodge hoslte and we have been having an amazing timewe met 2 guys from denmark who are geeks like us....really great guys they brought a car and invited us along to go with them to the shynege platte..beautiful view a cog train that goes up a mountain just a little south of innsbruck and boy the views were amazing all the mountains to the south laid out before yo

Day 2 Let the Walk Begin

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Corfu is all Venetian green and spoiled by the sun.Its richness enervates. Its valleys are painted out boldly in heavy brushstrokes of yellow and red. The Judas trees line the dusty roads in terrific purple explosions. Everywhere you go you can lie down on grass Lawrence Durrell Ok so we are about to find out if these words of some 65 years ago are true today.Usual continential brekfast of eg

home at last

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hey all just wanted to let you all know even though you probably already knew that i am home. After two plane rides I arrived last night greeted by my mom dad nanny and pa. Thank you all for coming we went to ininout and feasted on burgers so nice sorry for the late reply but i spent the whole day with my mom running errands and such. Well this is my last blog... If you get desperate

Zurich

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I arrived in Zurich after a very long day of trains. I woke at 400 am yesterday to catch the train from London to Paris. Then spent an hour in the train station there before heading to Zurich. I arrived there at 300pm whew So lets get this straight I spent Monday afternoon through Tuesday midday on a plane and all of Wednesday on train. I have been traveling every day for the majority of th

Day 49

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When we left England seven weeks ago we had 8 flights arranged round the world Philip today goes and books another five internal ones round Australia making it 13 in total. We now have return flights to the Gold coast for The half marathon. and flights to Melbourne Brisbane and back to Sydney to watch Everton. will we ever escape them before leaving for Hollywood on July 20th and heading for h

Office alone

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It's lunch time But I'm up in the office which if I haven't mentioned is actually an apartment with office desks set up not very conducive for working indeed but they're moving end June I think being antisocial and lunching alone. Actually I have been getting takeaway most days this week not really fond of the outside food and the hassle of eating the whole works from deciding where to

Mount Manganui and Zorb

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A few days before I climbed to the top of Mount Manganui Ines Katja Timo and I went along the main path with another German couple Alana and Tobias form the hostel. Anika and Kerstin decided to skip the climb as they had both done it on an earlier occasion. The hike to the top took about 45 minutes and we got very lucky as the weather stayed nice long enough for us to get back to the hostel

Kunming. Yuanyang. Nujiang.

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KunmingKunming is the capital of Yunnan province and Kunming is where we found ourselves on arrival at...Kunming. Bussing our way to the hostel what we found was sort of a city within a city. The Hump it's a WWII reference the name given to the Himalayan mountains by the pilots who had to fly over them is a sprawling seething metropolis of travellers both international and domestic. Im

Anchor Point AK to Seward AK

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It was cold this morning 38 Degrees. It warmed up pretty quickly and turned out to be a very pleasant day. We broke camp and drove north on the Stirling Hwy. South of Soldotna we saw a large bull moose in the road right of way. He was looking directly at us so all we got was head on photos. Saw a bunch of eagles but didn't get a single photo. We stopped in Sterling at an Antler Shop that s

arusha tanzania

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so its been a while here ............. so far all we have been doing really is the orientation which is a week long we r learning swahili by taking classes every morning and being tested on them also lots of hands on work like going down to the street and talkin to people about what we have learnt which btw haha sucks ..... a lady was pregnant and am like oh congratz u r having a child but

PLANTS in a desert.

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Las Vegas is fastly developing how fast you ask When I first moved to Vegas there was a road being built as in it was a dirt road. Now that road is fully paved and functioning. It's a pretty impressive thing. Except to get construction down so fast everything is cookie cutter and lots of corners are cut. When I got here we had an issue with our HOA home owners association. Basically there is