1809 1 Posted on Aug 11, 2017, 6 a.m.
Researchers have created a method to kill cancerous tissue without causing the harmful side effects of chemotherapy.
Medical researchers at the University of California, Irvine have created a stem cell-based method to zero in on cancerous tissue. This method kills the cancerous tissue without causing the nasty side effects of chemotherapy. Such side effects are avoided by treating the disease in a more localized manner. The advancement was spearheaded by associate professor of pharmaceutical sciences Weian Zhao. The details of the stem cell therapy were recently published in Science Translational Medicine.
About the new Stem Cell Therapy
Zhao's team programmed stem cells derived from human bone marrow to pinpoint the specific properties of cancerous tissue. They implemented a portion of code to these engineered cells to identify stiff cancerous tissue, lock onto it and implement therapeutics. The researchers safely used this new stem cell therapy in mice to kill metastatic breast cancer that had moved to the lungs. They transplanted these engineered stem cells in order for the teamto pinpoint and settle in the site of the tumor.
Once the stem cells reached the tumor, they released enzymes referred to as cytosine deaminase. The mice were then provided with an inactive chemotherapy known as prodrug 5-flurocytosine. The tumor enzymes stimulated the chemotherapy into action. Zhao stated his team zeroed in on metastatic cancer that occurs when the disease moves to additional parts of the body. Metastatic tumors are especially dangerous. They are responsible for90 percent of all cancer deaths.
Why the new Stem Cell Therapy is Important
Zhao is adamant his stem cell therapy represents an important newparadigm in the context of cancer therapy. Indeed, Zhao has blazed a trail in a new direction that others will likely follow in the years to come. It is possible his new stem cell therapy serves as an alternative and more effective means of treating cancer. This stem cell therapy will serve as an alternative to numerous forms of chemotherapy that typically have nasty side effects. Chemotherapy certainly kills plenty of growing cancer cells yet it can also harm healthy cells. The new type of treatment keys in on metastatic tissue that allows for the avoidance of the undesirable side effects produced by chemotherapy.
Though the published piece describing this stem cell therapy is centered on breast cancer metastases within thelungs, the method will soon be applicable to additional metastases. This is due to the fact that numerous solid tumors are stiffer than regular tissue. The new system does not force scientists to invest time and effort to pinpoint and create a brand new protein or genetic marker for each kind of cancer.
The Next Step
At this point in time, Zhao's team has performed pre-clinical animal studies to show the treatment is effective and safe. They plan to segue to human studies in the coming months and years. Zhao's team is currently expanding to additional types of cells such as cancer tissue-sensing and engineered immune system CAR-T (T cells) to treat metastasizing colon and breast cancers. Their goal is totransform this technology for the treatment of additional diseases ranging from diabetes to fibrosis and beyond.
Read more here:
Stem Cell Therapy Selectively Targets and Kills Cancerous Tissue - Anti Aging News
- Exercise Helps Heart Disease Patients Live Longer - November 8th, 2009 [November 8th, 2009]
- If You Have A Heart Attack, Dial 911, Don't Drive To The ER - November 8th, 2009 [November 8th, 2009]
- Dried Plums, Tart Cherries, Grapes- What do they have in common? - November 8th, 2009 [November 8th, 2009]
- Vitamin D for Me! - November 8th, 2009 [November 8th, 2009]
- Bangkok Hospital Named Best Global Hospital - November 8th, 2009 [November 8th, 2009]
- 10 Years of Stem Cell Science? Where's the Beef? - November 8th, 2009 [November 8th, 2009]
- Women Underestimate Heart Disease Risks - November 8th, 2009 [November 8th, 2009]
- A Stem Cell First- New Organ Created and Transplanted Using Adult Stem Cells - November 8th, 2009 [November 8th, 2009]
- Stem Cells Injected Directly Into the Heart- Sounds Familiar - November 8th, 2009 [November 8th, 2009]
- Heart Disease and Depression Are Linked - November 8th, 2009 [November 8th, 2009]
- TheraVitae Wishes Everyone A Happy Thanksgiving - November 8th, 2009 [November 8th, 2009]
- VesCell Adult Stem Cells Helping Pulmonary Hypertension - November 8th, 2009 [November 8th, 2009]
- VesCell Adult Stem Cells Help Dilated Cardiomyopathy Patient - November 8th, 2009 [November 8th, 2009]
- Another Dilated Cardiomyopathy Patient Helped by VesCell Adult Stem Cells - November 8th, 2009 [November 8th, 2009]
- Clinical Data of VesCell Used On Heart Disease Patients - November 8th, 2009 [November 8th, 2009]
- Results of Patients Treated with Adult Stem Cells for Heart Disease - November 8th, 2009 [November 8th, 2009]
- Results of Doctor Using VesCell for Heart Disease Published in Medical Journal - November 8th, 2009 [November 8th, 2009]
- Stem Cells from VesCell Help Another Patient With Congestive Heart Failure - November 8th, 2009 [November 8th, 2009]
- VesCell Uses Adult Stem Cells Not Fetal Stem Cells - November 8th, 2009 [November 8th, 2009]
- Dilated Cardiomyopathy Continues Improving After Stem Cell Therapy - November 8th, 2009 [November 8th, 2009]
- American Doctors Form Group to Oppose FDA's Stance On Adult Stem Cells - November 8th, 2009 [November 8th, 2009]
- Adult Stem Cell Pioneer Passes Away - November 8th, 2009 [November 8th, 2009]
- Dilated Cardiomyopathy Patient Celebrates His 1 Year Stem Cell Treatment Anniversary - November 8th, 2009 [November 8th, 2009]
- Vescell Featured In Forbes Magazine! - November 8th, 2009 [November 8th, 2009]
- Adult Stem Cells Repair Damaged Heart Muscle - November 8th, 2009 [November 8th, 2009]
- No Scooter Needed for Schlueter- Heart Disease Patient Back in Gym After Stem Cell Treatment - November 8th, 2009 [November 8th, 2009]
- Stem cells provide second chance - November 8th, 2009 [November 8th, 2009]
- Adult Stem Cell Therapy Scientific Advisory Board - November 8th, 2009 [November 8th, 2009]
- Partner hospitals give Heart Disease treatment with Adult Stem Cell Therapy - November 8th, 2009 [November 8th, 2009]
- Stem Cell Treating Physicians for Heart Disease - Vescell by Theravitae - November 8th, 2009 [November 8th, 2009]
- Heart Disease Treatment FAQs - Adult Stem Cells Treats Heart Disease - November 8th, 2009 [November 8th, 2009]
- Checklist of 12 Must-Ask Questions for Overseas Treatment - November 8th, 2009 [November 8th, 2009]
- Health teaching for patients with heart disease | VesCell adult stem cell therapy - November 8th, 2009 [November 8th, 2009]
- Ethical Debates Adult Stem Cell Research | VesCell adult stem cells treatment - November 8th, 2009 [November 8th, 2009]
- Heart disease and health policy and nurse | VesCell adult stem cells treatment - November 8th, 2009 [November 8th, 2009]
- After Stent Symptoms | VesCell Adult Stem Cell Therapy - November 8th, 2009 [November 8th, 2009]
- What is adult stem cell research | VesCell Adult Stem Cell Therapy - November 8th, 2009 [November 8th, 2009]
- Alternative Medicine for Coronary Artery Disease | VesCell Adult Stem Cell Therapy - November 8th, 2009 [November 8th, 2009]
- Diabetic, Seven Heart Attack Patient Experiences on Adult Stem Cell Treatment - November 8th, 2009 [November 8th, 2009]
- Congestive Heart Failure and Life Expectancy | VesCell Adult Stem Cell Therapy - November 8th, 2009 [November 8th, 2009]
- Chest Pain After Angioplasty with Stent | VesCell adult stem cells treatment - November 8th, 2009 [November 8th, 2009]
- Use of Stem Cells for Heart Repair | VesCell Adult Stem Cell Therapy - November 8th, 2009 [November 8th, 2009]
- Women health heart attack - November 8th, 2009 [November 8th, 2009]
- Health Facts on the Heart | VesCell Adult Stem Cells Treatment - November 8th, 2009 [November 8th, 2009]
- The Process of Stem Cells | VesCell Adult Stem Cells Treatment - November 8th, 2009 [November 8th, 2009]
- Rest Pain Leg | VesCell adult stem cells for peripheral artery disease - November 8th, 2009 [November 8th, 2009]
- Health Supplements Heart Diabetes | VesCell Adult Stem Cells Treatment - November 8th, 2009 [November 8th, 2009]
- Heart Failure Epidemic | VesCell adult stem cells treatment - November 8th, 2009 [November 8th, 2009]
- Heart Muscle Health Aspects | VesCell adult stem cell therapy - November 8th, 2009 [November 8th, 2009]
- adult stem cells | VesCell adult stem cells treatment - November 8th, 2009 [November 8th, 2009]
- Updated article about adult stem cells therapy, VesCell, as featured in Forbes Magazine - November 8th, 2009 [November 8th, 2009]
- Forbes: Vescell Stem Cell Therapy Saves Heart Failure Patient - November 8th, 2009 [November 8th, 2009]
- Foetal Stem Cells Offer Hope for Stroke Victims - November 8th, 2009 [November 8th, 2009]
- Stem cells could spell end for diabetes jabs - November 8th, 2009 [November 8th, 2009]
- Full text answers about stem cell research - November 8th, 2009 [November 8th, 2009]
- Stem Cell Transplant from Umbilical Cord Blood Is The Only Hope for SCID Sufferer - November 8th, 2009 [November 8th, 2009]
- New Studies About Umbilical Cord Blood And Children With Diabetes - November 8th, 2009 [November 8th, 2009]
- Engineered Blood Vessels Function Like Native Tissu - November 8th, 2009 [November 8th, 2009]
- Umbilical Cord Blood Stem Cells Provide Hope for Life Threatening Diseases - November 8th, 2009 [November 8th, 2009]
- Gov. Schwarzenegger Signs SB962 to Create a System to Collect and Store Umbilical Cord Blood - November 8th, 2009 [November 8th, 2009]
- Baby Boy Treated for Cerebral Palsey with His Own Cord Blood Stem Cells - November 8th, 2009 [November 8th, 2009]
- Cord Blood May Preserve Insulin Production in Newly Diagnosed Children With Type 1 Diabetes - November 8th, 2009 [November 8th, 2009]
- A "Holy Grail" Of Healing, CBS Evening News - November 8th, 2009 [November 8th, 2009]
- After Receiving Unusual Stem Cell Transplant, Coppell Toddler Comes Home from Hospital - November 8th, 2009 [November 8th, 2009]
- Stem Cell Hope for Bone Fractures - November 8th, 2009 [November 8th, 2009]
- Cord Blood Stem Cells And Cardiovascular Disease - November 8th, 2009 [November 8th, 2009]
- Creating a Cord-Blood Lifeline - November 8th, 2009 [November 8th, 2009]
- Saving Cord Blood - November 8th, 2009 [November 8th, 2009]
- Stem Cell Implant to the Brain Helps Improve Parkinson's Symptoms: Presented at SIR - November 8th, 2009 [November 8th, 2009]
- Governor Rendell Signs Bill Into Law - November 8th, 2009 [November 8th, 2009]
- Curing Blood Diseases: How Cord Blood Saves Lives - November 8th, 2009 [November 8th, 2009]
- Cord Blood Registry Gains Momentum in First Quarter; Forecasts Strong Enrollment Growth in 2008 - November 8th, 2009 [November 8th, 2009]
- Study findings from University of Florida, Department of Pediatrics provide new insights into cord blood - November 8th, 2009 [November 8th, 2009]
- Cord Blood Can Be Used To Treat Adult Leukemia - November 8th, 2009 [November 8th, 2009]
- Umbilical cord a lifeline for 2 kids - November 8th, 2009 [November 8th, 2009]
- For Stem Cells, a Role on the Battlefield - November 8th, 2009 [November 8th, 2009]
- Cochlear Repair After Transplant Of Human Cord Blood Cells May Make Hearing Restoration Possible - November 8th, 2009 [November 8th, 2009]
- About Stem Cells - November 8th, 2009 [November 8th, 2009]
- Stem cells: Small wonders - November 8th, 2009 [November 8th, 2009]
- Stem Cell Therapy Lessens Damage Caused By Stroke - November 8th, 2009 [November 8th, 2009]