Cassini reveals incredible vanishing 'Magic Islands' on Saturn's largest moon

Recent images from NASA's Cassini spacecraft, currently touring Saturn and its moons, have revealed Brigadoon-likeislands on one of Titan's largest seas, features that appear, disappear, then re-appear.

Scientists have whimsically named these Magic Islands. Their vanishing act is one of several recent discoveries planetary scientists have made regarding the northern hemisphere's liquid-hydrocarbon seas and lakes at a time when the hemisphere heads toward its summer solstice.

These vast reservoirs of liquid hydrocarbons are centered around the moon's north pole region, where they are thought to play a key role in the moon's equivalent to Earth's water cycle. In Titan's case, it's the methane cycle, where the liquid methane at the surface of the lakes and seas evaporates, rises to condense as clouds, then returns to the surface as methane rain. Liquid methane flows in to streams and rivers, sculpting the moon's surface on their return to lakes and seas.

These features are strikingly similar to processes on Earth, making Titan Saturn's largest moon an explorer's Utopia, said Alexander Hayes, a planetary scientist at Cornell University during a briefing at a meeting of the American Astronomical Society's Division of Planetary Sciences in Tucson, Ariz. Dr. Hayes is a member of the science team reporting the results at the meeting.

Researchers first discovered a magic island just off of a peninsula jutting into Ligeia Mare, Titan's second largest sea a body of mainly liquid methane that covers slightly more than 48,600 square miles of the moon's surface.

The team detected it in July 2013 using Cassini's radar. When the team looked again about 16 days later, the feature was gone. On another Cassini pass over Titan in August, the feature reappeared. It was unclear if the feature the radar detected was a surface feature, such as the action of tiny waves, or perhaps represented a geological structure that only revealed itself when the viewing angle was just right.

Cassini's August pass provided the answer when it discovered a similar feature in Kraken Mare, the largest of the moon's northern-hemisphere seas. In addition to radar, Cassini's Visual and Infrared Mapping Spectrometer also spotted a magic-island feature in Kraken Mare. The spectrometer's data suggested that either small waves or wet ground was responsible for the signature the instrument picked up.

The team is leaning to the wave interpretation because given the size of Kraken Mare it covers some 154,000 square miles, roughly the size of the Caspian or Black Seas the sea would have had to have lost a fair bit of methane to expose even a shallow bottom at that location and over such a wide area.

Such wave action would be expected as the northern hemisphere warms and kicks up winds.

Cassini also has proven unexpectedly adept at determining the depths of the seas as well as their composition, Dr. Hayes explained.

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Cassini reveals incredible vanishing 'Magic Islands' on Saturn's largest moon

What Is The Definition Of Single payer health care Medical School Terminology Dictionary – Video


What Is The Definition Of Single payer health care Medical School Terminology Dictionary
Visit our website for text version of this Definition and app download. http://www.medicaldictionaryapps.com Subjects: medical terminology, medical dictionary, medical dictionary free download,...

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What Is The Definition Of Single payer health care Medical School Terminology Dictionary - Video

The new Veterans Affairs secretary explains how he will fix department – Video


The new Veterans Affairs secretary explains how he will fix department
Bob McDonald told us the reorganization will streamline management and the way veterans get their benefits, including everything from college loans, mortgages, health care and burial plots....

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Catholic Bishops Weigh Tightening Rules for Health Care Partnerships

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With Catholic health systems expanding, stricter rules could have implications for reproductive and maternity care across the country.

With Catholic health systems expanding, stricter rules could have implications for reproductive and maternity care across the country.

by Nina Martin ProPublica, Nov. 11, 2014, 10:17 a.m.

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The 2011 merger of the two remaining hospitals in Troy, N.Y., had many potential benefits and one huge hurdle.

Samaritan was secular, committed to providing the widest possible spectrum of reproductive and maternity care to its Albany-area patients. St. Mary's was Catholic, limiting or banning many reproductive options and any merger partner had to abide by the same rules.

It took several years of negotiations among three different health systems, much back-and-forth with women's advocates, and the sign-off of the local bishop. But in the end, the parties struck a deal that all of them could live with. The centerpiece was the brand-new Burdett Care Center, housed on Samaritan's second floor.

To all appearances, Burdett was a typical maternity ward. But in reality, it was a separately incorporated hospital-within-a-hospital, secular and thus free from the Catholic restrictions that Samaritan had agreed to follow. Burdett could provide birth control and perform tubal ligations; if a woman was having a miscarriage or ectopic pregnancy, doctors could treat her according to generally accepted standards of care.

Complicated? Yes. Cumbersome? Very. Still, as a compromise to preserve access to care in Troy, "it's worked very well," said Lois Uttley of the nonprofit group MergerWatch, which helped broker the arrangement.

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Catholic Bishops Weigh Tightening Rules for Health Care Partnerships

Oakland woman brings health care and sense of home to local immigrants

OAKLAND -- By some standards, Laura Lopez isn't qualified to run a nonprofit -- let alone the one that she has built into one of the East Bay's most pioneering health care services.

Her only degree is from a high school in Lima, Peru. And her English still isn't good enough to write a grant proposal.

When the founders of an organization created to provide health care to undocumented day laborers decided a decade ago to promote Lopez from outreach worker to executive director, she wasn't even sure what her new title meant.

"I asked, 'Does being executive director mean I can still go in the street and talk to the people?'" she recalled. "And they said, 'Yes.'"

Laura Lopez, executive director of the Street Level Health Project, is photographed at the center in Oakland, Calif., on Wednesday, Oct. 29, 2014. (Laura A. Oda/Bay Area News Group) ( Laura A. Oda )

These days, the only part of the job Lopez hasn't mastered is knowing when to call it a night and go home to her family.

Under her leadership, the Street Level Health Project has grown from a health clinic operating one day a week out of a single room in an abandoned hospital to a full-fledged community center in Oakland's Fruitvale district that serves people speaking 55 different languages. Depending on the day, visitors can see a doctor, get something to eat, take a class, meet their friends or get a referral for additional services such as legal advice or help finding housing.

Perhaps the center's most important function is as an entry point into Alameda County's health care system. The county is unique in that it provides medical coverage to undocumented workers, but getting them enrolled has been a big challenge, said Alex Briscoe, director of the Alameda County Health Care Services Agency.

Many undocumented workers, leery of deportation, stay away from government-sanctioned programs. But Lopez has proved so skilled at earning their trust and getting them to seek medical care that the county set up centers in Hayward and Berkeley that are modeled on Street Level's community-based approach.

Last year, the nonprofit's doctors saw nearly 1,000 patients, many of whom were referred to the county's program, which offers more advanced primary or specialty care.

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Oakland woman brings health care and sense of home to local immigrants

Health Care Sector Update for 11/11/2014: PTLA, ICUI, ENZY, BMY, PFE

Top Health Care Stocks

JNJ +0.11%

PFE +0.17%

ABT +0.58%

MRK +1.36%

AMGN -0.07%

Health care stocks were mostly higher, with the NYSE Health Care Sector Index adding about 0.5% and shares of health care companies in the S&P 500 ahead about 0.4% as a group.

In company news, Portola Pharmaceuticals ( PTLA ) was see-sawing between small losses and gains, bouncing back from a steeper decline earlier Tuesday after the biotech company reported below-consensus revenue during its July-to-September quarter while its per-share earnings topped analyst estimates.

The company reported a $35.8 million, or $0.86 per share, net loss, almost double its $18.6 million net loss last year but still beating the Capital IQ consensus by $0.06 per share.

Revenue fell 14.3% compared with the same quarter last year to $2.4 million as collaboration income from PTLA's work with Bristol-Myers Squibb Company ( BMY ) and Pfizer ( PFE ), Bayer Pharma and Janssen Pharmaceuticals, Daiichi Sankyo and Lee's Pharmaceuticals slid $400,000 from last year. The Street was looking for $2.63 million in reveneue.

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Health Care Sector Update for 11/11/2014: PTLA, ICUI, ENZY, BMY, PFE

Multiple models reveal new genetic links in autism

PUBLIC RELEASE DATE:

11-Nov-2014

Contact: Scott LaFee slafee@ucsd.edu 619-543-6163 University of California - San Diego @UCSanDiego

With the help of mouse models, induced pluripotent stem cells (iPSCs) and the "tooth fairy," researchers at the University of California, San Diego School of Medicine have implicated a new gene in idiopathic or non-syndromic autism. The gene is associated with Rett syndrome, a syndromic form of autism, suggesting that different types of autism spectrum disorder (ASD) may share similar molecular pathways.

The findings are published in the Nov. 11, 2014 online issue of Molecular Psychiatry.

"I see this research as an example of what can be done for cases of non-syndromic autism, which lack a definitive group of identifying symptoms or characteristics," said principal investigator Alysson Muotri, PhD, associate professor in the UC San Diego departments of Pediatrics and Cellular and Molecular Medicine. "One can take advantage of genomics to map all mutant genes in the patient and then use their own iPSCs to measure the impact of these mutations in relevant cell types. Moreover, the study of brain cells derived from these iPSCs can reveal potential therapeutic drugs tailored to the individual. It is the rise of personalized medicine for mental/neurological disorders."

But to effectively exploit iPSCs as a diagnostic tool, Muotri said researchers "need to compare neurons derived from hundreds or thousands of other autistic individuals." Enter the "Tooth Fairy Project," in which parents are encouraged TO register for a "Fairy Tooth Kit," which involves sending researchers like Muotri a discarded baby tooth from their autistic child. Scientists extract dental pulp cells from the tooth and differentiate them into iPSC-derived neurons for study.

"There is an interesting story behind every single tooth that arrives in the lab," said Muotri.

The latest findings, in fact, are the result of Muotri's first tooth fairy donor. He and colleagues identified a de novo or new disruption in one of the two copies of the TRPC6 gene in iPSC-derived neurons of a non-syndromic autistic child. They confirmed with mouse models that mutations in TRPC6 resulted in altered neuronal development, morphology and function. They also noted that the damaging effects of reduced TRPC6 could be rectified with a treatment of hyperforin, a TRPC6-specific agonist that acts by stimulating the functional TRPC6 in neurons, suggesting a potential drug therapy for some ASD patients.

The researchers also found that MeCP2 levels affect TRPC6 expression. Mutations in the gene MeCP2, which encodes for a protein vital to the normal function of nerve cells, cause Rett syndrome, revealing common pathways among ASD.

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Multiple models reveal new genetic links in autism

If Your Cat Doesnt Like You Much, Blame Its Genome

The first close look at the genetic code of a domestic cat suggests that food rewards from people brought man and feline together, based on genome variations associated with memory and reward behaviors.

The study also identified how cats evolved to lead solitary, meat-eating lives, and finds that, perhaps unsurprisingly, cats arent quite as domesticated as dogs.

The domestic cat genome shows a relatively small number of changed genetic regions compared to domesticated dogs, said Wesley Warren of the Genome Institute at Washington University School of Medicine in Saint Louis, who led the study. Cats are clearly still very independent in their behaviors, and, importantly, still interbreed with wild populations.

Americans alone own 96 million cats, according to the Humane Society. The findings, published yesterday in the Proceedings of the National Academy of Sciences, may help researchers better understand and treat cat diseases, including illnesses shared with humans, such as kidney calcification.

Cat domestication began about 9,000 years ago, an estimate based on the remains of a cat laid carefully next to those of a human at an ancient Cyprus burial site, though most of the 30 to 40 cat breeds today originated just 150 years ago, previous research has found.

To examine what happened during that domestication process, Warren and colleagues sequenced the genome of a female Abyssinian cat named Cinnamon and compared her DNA to genomes from six other domestic cat breeds, two wild cat species, and to the genome of a tiger, dog, cow, and human.

Many of the genes identified as changed in domestic cats have been linked to reward responses, memory and fear conditioning, studies in mice have shown. The genome changes suggest cats became tame as they became less fearful of humans and more responsive to being rewarded with food.

The feline genetic code also offered insight into how cats evolved away from other mammals.

Compared to omnivorous humans and herbivorous cows, carnivorous cats appear to have more quickly evolved genes that bestow an enhanced ability to digest heavy fats found in meat. A study in polar bears published earlier this year found the same genetic adaptation in the DNA of the meat-loving Arctic bear.

In addition, by comparing cat and dog genomes, the researchers found a unique evolutionary trade-off between the two groups: While dogs evolved an unsurpassed sense of smell, cats traded in those smell receptor genes for genes that enhanced their ability to sense pheromones, odorless substances that enable animals of the same species to communicate, such as to find a mate.

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If Your Cat Doesnt Like You Much, Blame Its Genome

Zelig Eshhar and Carl H. June honored for research on T cell engineering for cancer immunotherapy

PUBLIC RELEASE DATE:

11-Nov-2014

Contact: Kathryn Ryan kryan@liebertpub.com 914-740-2100 Mary Ann Liebert, Inc./Genetic Engineering News @LiebertOnline

New Rochelle, NY, November 11, 2014--Zelig Eshhar, PhD, The Weizmann Institute of Science and Sourasky Medical Center, and Carl H. June, MD, PhD, Perelman School of Medicine, University of Pennsylvania, are co-recipients of the Pioneer Award, recognized for lentiviral gene therapy clinical trials and for their leadership and contributions in engineering T-cells capable of targeting tumors with antibody-like specificity through the development of chimeric antigen receptors (CARs). Human Gene Therapy, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers, is commemorating its 25th anniversary by bestowing this honor on the leading Pioneers in the field of cell and gene therapy selected by a blue ribbon panel* and publishing a Pioneer Perspective by the award recipients. The Perspectives by Dr. Eshhar and Dr. June are available free on the Human Gene Therapy website at http://www.liebertpub.com/hgt until December 11, 2014.

In his Pioneer Perspective entitled "From the Mouse Cage to Human Therapy: A Personal Perspective of the Emergence of T-bodies/Chimeric Antigen Receptor T Cells" Professor Eshhar chronicles his team's groundbreaking contributions to the development of the CAR T-cell immunotherapeutic approach to treating cancer. He describes the method's conceptual development including initial proof-of-concept, and the years of experimentation in mouse models of cancer. They first tested the CAR T-cells on tumors transplanted into mice then progressed to spontaneously developing cancers in immune-competent mice, which Dr. Eshhar describes as "a more suitable model that faithfully mimics cancer patients." He recounts successful antitumor effects in mice with CAR modified T-cells injected directly into tumors, with effects seen at the injection site and at sites of metastasis, and even the potential of the CAR T-cells to prevent tumor development.

Dr. Carl H. June has led one of the clinical groups that has taken the CAR therapeutic strategy from the laboratory to the patients' bedside, pioneering the use of CD19-specific CAR T-cells to treat patients with leukemia. In his Pioneer Perspective, "Toward Synthetic Biology with Engineered T Cells: A Long Journey Just Begun" Dr. June looks back on his long, multi-faceted career and describes how he combined his knowledge and research on immunology, cancer, and HIV to develop successful T-cell based immunotherapies. Among the lessons Dr. June has embraced throughout his career are to follow one's passions. He also says that "accidents can be good: embrace the unexpected results and follow up on these as they are often times more scientifically interesting than predictable responses from less imaginative experiments."

"These two extraordinary scientists made seminal contributions at key steps of the journey from bench to bedside for CAR T-cells," says James M. Wilson, MD, PhD, Editor-in-Chief of Human Gene Therapy, and Director of the Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia.

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*The blue ribbon panel of leaders in cell and gene therapy, led by Chair Mary Collins, PhD, MRC Centre for Medical Molecular Virology, University College London selected the Pioneer Award recipients. The Award Selection Committee selected scientists that had devoted much of their careers to cell and gene therapy research and had made a seminal contribution to the field--defined as a basic science or clinical advance that greatly influenced progress in translational research.

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Zelig Eshhar and Carl H. June honored for research on T cell engineering for cancer immunotherapy

Our wine owes a debt to ancient viruses

Next time you pour a glass of wine, raise a toast to the 30-milion-year-old viruses that have contributed to the genetic make-up of modern grapes.

A team of UQ-led plant scientists has discovered that the Pinot Noir grape variety owes a significant part of its genetic heritage to ancient plant viruses.

In a study published in Nature Communications, Dr Andrew Geering and colleagues have mapped the presence of 30-million-year-old viruses in Pinot Noir DNA.

Viruses are usually a curse to farmers because of the damage they cause to crops, but this study also suggests they play a vital evolutionary role.

Dr Geering, a plant pathologist at the UQs Queensland Alliance for Agriculture and Food Innovation, said most flowering plant species, even the most primitive ones, contain sequence signatures of viruses in their genetic material.

Animals can move to avoid threats but because plants are anchored to the ground they are obliged to adapt to environmental pressures, such as those brought about by drought or grazing, using novel strategies.

Plants cope with such threats by acquiring new biochemical pathways or growth habits.

Pulling new genetic material from the environment, such as from viruses that infect the plant, means evolution can be sped up considerably.

Much like humans, plants are regularly exposed to harmful chemicals or radiation, which can cause damaging and heritable mutations to their genes which, if left unrepaired, could be lethal to their descendants.

Fortunately, there are special mechanisms to repair these mutations. Its during this repair procedure that foreign DNA such as that originating from viruses can be inserted into the plants own genetic code, much like using putty to fill a crack in the wall.

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Our wine owes a debt to ancient viruses