Official Jailbreak Islands (by Derek Lam) Launch Trailer (iOS / Android) – Video

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Official Jailbreak Islands (by Derek Lam) Launch Trailer (iOS / Android)
Jailbreak Islands by Derek Lam (iOS / Android) Monkeying around has never been more fun or useful than it is in Jailbreak Islands, a brand new mischievous puzzle solving adventure that #39;ll...

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Official Jailbreak Islands (by Derek Lam) Launch Trailer (iOS / Android) - Video

Oasis Maspalomas El Sol – Gran Canaria – Canary Islands – besthotelinfo.com – Video

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Oasis Maspalomas El Sol - Gran Canaria - Canary Islands - besthotelinfo.com
Link to the review of Oasis Maspalomas El Sol: http://www.besthotelinfo.com/default.asp?m=hotel id=00133 hotel=Oasis_Maspalomas_-_El_Sol,_Picnic_ _Foresta Oasis Maspalomas El Sol was ...

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Oasis Maspalomas El Sol - Gran Canaria - Canary Islands - besthotelinfo.com - Video

Why Future Islands’ ‘Seasons’ Is NME’s Top Track Of 2014 – Video

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Why Future Islands #39; #39;Seasons #39; Is NME #39;s Top Track Of 2014
Future Islands #39; #39;Seasons (Waiting On You) #39; is NME #39;s Top Track of 2014, beating Caribou, St Vincent, Jamie T and loads more to the post. NME writers discuss why the track is worthy of the top spot.

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Why Future Islands' 'Seasons' Is NME's Top Track Of 2014 - Video

China to continue building on disputed islands, retired PLA general says

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HONG KONG China's land reclamation work on a reef in a disputed island chain in the South China Sea is justified and will continue, a retired People's Liberation Army major general said in an interview with state media.

China is likely to withstand international pressure over Fiery Cross Reef, Maj. Gen. Luo Yuan said, according to a report in the Global Times, a state-run newspaper.

In the past three months China reclaimed land around the reef, creating an island large enough to enable its first airstrip in the Spratly Islands, IHS Jane's reported Nov. 20, citing satellite pictures of the area.

Artificial islands could help China anchor its territorial assertions and potentially develop bases near waters that host some of the world's busiest shipping lanes. China claims about 90 percent of the South China Sea, parts of which are also claimed by Brunei, Malaysia, the Philippines, Taiwan and Vietnam.

The United States urged China to stop reclaiming land and engage in diplomatic initiatives to encourage all claimants to show restraint, Agence France-Presse reported, citing Pentagon spokesman Lt. Col. Jeffrey Pool. In August, China rebuffed efforts by Secretary of State John Kerry to secure a freeze on any actions that might provoke tensions in the waters.

China's construction activities in the islands are to improve working and living conditions of stationed personnel to aid them fulfill their search and rescue obligations, Foreign Ministry spokeswoman Hua Chunying told reporters Monday in Beijing. "External forces have no right to make irresponsible remarks," she said.

Luo told the Global Times that the U.S. was biased because the Philippines, Malaysia and Vietnam have set up military facilities in the Spratly islands.

The Philippine government is seeking to validate the report of China building an airstrip and harbor on Fiery Cross Reef, Foreign Affairs Secretary Albert del Rosario told reporters Monday in Manila. President Benigno Aquino and his Chinese counterpart Xi Jinping have expressed a desire to improve bilateral relations and that can happen while the country seeks to resolve its maritime claims through United Nations arbitration, he said.

Until the reclamation project started, Fiery Cross was underwater, with the only habitable area a concrete platform built and maintained by the PLA Navy, IHS Jane's said.

The new island is more than 3,000 meters long and between 200 and 300 meters wide, IHS Jane's said, citing satellite images taken between Aug. 8 and Nov. 14. Dredgers are constructing a harbor to the east of the reef that appears to be large enough to receive tankers and naval vessels, it said.

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China to continue building on disputed islands, retired PLA general says

Link between DNA transcription, disease-causing expansions

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Researchers in human genetics have known that long nucleotide repeats in DNA lead to instability of the genome and ultimately to human hereditary diseases such Freidreich's ataxia and Huntington's disease.

Scientists have believed that the lengthening of those repeats occur during DNA replication when cells divide or when the cellular DNA repair machinery gets activated. Recently, however, it became apparent that yet another process called transcription, which is copying the information from DNA into RNA, could also been involved.

A Tufts University study published online on November 20 in the journal Cell Reports by a research team lead by Sergei Mirkin, the White Family Professor of Biology at Tufts' School of Arts and Sciences, along with former graduate student Kartick Shah and graduate students Ryan McGuity and Vera Egorova, explores the relationship between transcription and the expansions of DNA repeats. It concludes that the active transcriptional state of a DNA segment containing a DNA repeat predisposes it for expansions. The print version of the study will be published on December 11.

"There are a great many simple repetitive motifs in our DNA, such as GAAGAAGAA or CGGCGGCGG," says Mirkin. "They are stable and cause no harm if they stay short. Occasionally, however, they start lengthening compulsively, and these uncontrollable expansions lead to dramatic changes in genome stability, gene expression, which can lead to human disease."

In their study, the researchers used baker's yeast to monitor the progress and the fundamental genetic machineries for transcription, replication and repair in genome functioning.

"The beauty of the yeast system is that it provides one with a practically unlimited arsenal of tools to study the mechanisms of genome functioning," says Mirkin. "We created genetic systems to track down expansions of the repeats that were positioned in either transcribed or non-transcribed parts of reporter genes."

After measuring the rate of repeat expansions in all these cases, the authors found that a repeat can expand under the condition when there is practically no transcription, but the likelihood of the expansion process is drastically (10-fold) higher when the reporter is transcriptionally active.

Surprisingly, however, transcription machinery does not need to physically pass through the repeat to stimulate its expansion. Thus, it is the active transcription state of the repeat-containing DNA segment, rather than RNA synthesis through the repeat that promotes expansions.

In the transcriptionally active state, DNA is packaged in chromatin more loosely than when it is transcriptionally inactive. More specifically, the density of nucleosomes along the transcribed DNA segment is significantly lower than that in the non-transcribed segment. This packaging of repetitive DNA within the transcribed areas gives much more room for DNA strand gymnastics, ultimately leading to repeat expansions.

Whatever the exact model, says Mirkin, the fact that expandable DNA repeats were always found in transcribed areas of our genome may not be that surprising after all.

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Link between DNA transcription, disease-causing expansions

A link between DNA transcription and disease-causing expansions

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PUBLIC RELEASE DATE:

25-Nov-2014

Contact: Alex Reid alexander.reid@tufts.edu 617-627-4173 Tufts University @TuftsUniversity

Medford/Somerville, Mass--Researchers in human genetics have known that long nucleotide repeats in DNA lead to instability of the genome and ultimately to human hereditary diseases such Freidreich's ataxia and Huntington's disease.

Scientists have believed that the lengthening of those repeats occur during DNA replication when cells divide or when the cellular DNA repair machinery gets activated. Recently, however, it became apparent that yet another process called transcription, which is copying the information from DNA into RNA, could also been involved.

A Tufts University study published online on November 20 in the journal "Cell Reports" by a research team lead by Sergei Mirkin, the White Family Professor of Biology at Tufts' School of Arts and Sciences, along with former graduate student Kartick Shah and graduate students Ryan McGuity and Vera Egorova, explores the relationship between transcription and the expansions of DNA repeats. It concludes that the active transcriptional state of a DNA segment containing a DNA repeat predisposes it for expansions. The print version of the study will be published on December 11.

"There are a great many simple repetitive motifs in our DNA, such as GAAGAAGAA or CGGCGGCGG," says Mirkin. "They are stable and cause no harm if they stay short. Occasionally, however, they start lengthening compulsively, and these uncontrollable expansions lead to dramatic changes in genome stability, gene expression, which can lead to human disease."

In their study, the researchers used baker's yeast to monitor the progress and the fundamental genetic machineries for transcription, replication and repair in genome functioning.

"The beauty of the yeast system is that it provides one with a practically unlimited arsenal of tools to study the mechanisms of genome functioning," says Mirkin. "We created genetic systems to track down expansions of the repeats that were positioned in either transcribed or non-transcribed parts of reporter genes."

After measuring the rate of repeat expansions in all these cases, the authors found that a repeat can expand under the condition when there is practically no transcription, but the likelihood of the expansion process is drastically (10-fold) higher when the reporter is transcriptionally active.

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A link between DNA transcription and disease-causing expansions