The Clinical Promise of the Gene Therapy from Harrison’s Principles of IM, 19th Edition – Video

Posted on by


The Clinical Promise of the Gene Therapy from Harrison #39;s Principles of IM, 19th Edition
Dr. J. Larry Jameson, editor for Harrison #39;s Principles of Internal Medicine, discusses the clinical promise of the gene therapy. Visit http://www.HarrisonsIM.com to watch more videos of Dr. J. Larry...

By: McGrawHIllPro

The rest is here:

The Clinical Promise of the Gene Therapy from Harrison's Principles of IM, 19th Edition - Video

Gene study finds link with implications for melanoma therapy

Posted on by

Lawrence, KS (PRWEB) February 18, 2015

Pediatric and Developmental Pathology An odd-looking or changing mole or birthmark is always worrisome, particularly on a child. While most are benign, cancer jumps into every parents mind. Gene studies and potential related therapies are just one front in the wide-ranging battle against melanoma.

An analysis in the new issue of the journal Pediatric and Developmental Pathology looks at the link between the typical clinical features of two diseases and the status of two genes. In their study, researchers confirmed that a mutation of the BRAF gene affects people with large or giant birthmarks known as congenital melanocytic nevi (CMNs) and, for the first time, they also found this mutation present in neurocutaneous melanocytosis, a rare neurological disorder associated with Large/Giant CMNs. They suggest that it may be possible to target the BRAF gene during therapy.

CMNs are literally birthmarks, developing in the womb as a fetus grows. Such a dark-colored, sometimes hairy, patch of skin can continue to develop as the child grows, and if it reaches 20 cm or more, it is classified as large or giant. Although usually benign at birth, they can associate with a range of other problems, from decreased sweating and tissue growth to a greater likelihood of melanoma, a skin cancer that is becoming increasingly common worldwide among adults and even teenagers. Neurocutaneous melanocytosis, in which the pigment cells rapidly spread across the brain, spinal cord and meninges, can also develop.

The current study collected pigmented tissue from 66 patients with Large/Giant CMN. The authors first looked for the more commonly mutated NRAS gene and then evaluated those tissues without NRAS mutation for BRAF mutation.

The authors found a new link between BRAF mutations and aggressive disease pattern. They learned of a definite association between the BRAF gene and large or giant CMNs. They also discovered, for the first time, that some patients with neurocutaneous melanocytosis had BRAF but not NRAS mutation. Race was a factor in the appearance of a mutational group, with Asians less likely to show the BRAF mutation.

Surprisingly, more nodules were found in the pigmented skin among people who had the BRAF mutation than among those with the NRAS mutation. Less hair was also found with the BRAF mutation.

The authors concluded that not only NRAS mutations can occur in the studied conditions. They also learned that BRAF mutations may be responsible for more serious disease than previously thought. They said that this means it may be possible to use BRAF inhibitors to target the mutated BRAF gene when treating patients with large or giant CMNs.

Full text of the article BRAF mutations are also associated with neurocutaneous melanocytosis and large/giant congenital melanocytic nevi, Pediatric and Developmental Pathology, Vol. 18, No. 1, 2014, is now available.

###

See original here:

Gene study finds link with implications for melanoma therapy

Futurist Jack Uldrich to Address Technological Trends and Future Proofing in the Medical Device Industry

Posted on by

Minneapolis, MN (PRWEB) February 18, 2015

"One word: Plastics." This quote was funny, pithy and incredibly insightful back in 1967 from the film "The Graduate." Forty-seven years later, it actually is one of the great truths within the medical device industry. Futurist Jack Uldrich will elaborate on technological advances that have changed the shape of things to come and how leaders in the medical device industry can future-proof themselves for the sea of changes that are coming.

The leading medical device manufacturer that Uldrich will address in Minneapolis on February 18th provides a wide range of manufacturing capabilities including machining, plastic injection molding, stamping, metal forming and clean room assembly and packaging. Uldrich will deliver his keynote, "The Big AHA: How to Future Proof the Medical Device Industry." In the presentation he will outline for their audience members the ten technological trends that will transform the medical device world of tomorrow. Uldrich also aims to help them identify concrete actions they can take today to future-proof themselves against the tides of tomorrow.

"In the near future, the greatest change will be the accelerating rate of change," says Uldrich. While Uldrich will outline the tech trends that will be transforming the industry he will also address future-proofing. "The key to future-proofing is embracing paradox: learning to unlearn, thinking about the unthinkable, recognizing failure as a key component of success, and understanding that an awareness of ones ignorance is a key component of true wisdom."

A selection of Uldrich's previous clients include Emerson, ABB, St. Jude, Boston Scientific, Medtronic, Pfizer, United Healthcare and Allina. He travels the world speaking and writing on the transformation of health care, agriculture, education, energy, finance, retail and manufacturing. He argues that creativity and action are more powerful and versatile than knowledge. And he reminds people that forty-seven years ago, while "Plastics" may have seemed like a joke it is now one of the waves of the future.

Parties interested in learning more about Jack, his books, his daily blog or his speaking availability are encouraged to visit his website. Media wishing to know more about either the event or interviewing Jack as a futurist or trend expert can contact Amy Tomczyk at (651) 343.0660.

Read the original post:

Futurist Jack Uldrich to Address Technological Trends and Future Proofing in the Medical Device Industry

Dying Light Part 2 FREEDOM… On Second Thought / (Xbox One Walkthrough) – Video

Posted on by


Dying Light Part 2 FREEDOM... On Second Thought / (Xbox One Walkthrough)
Good Night Good Luck. Enter a world overrun by a vicious outbreak. Scavenge for supplies, craft weapons, and fight blood-thirsty Infected. Survive to live another day. We enter the life...

By: MajorFogs277

Go here to see the original:

Dying Light Part 2 FREEDOM... On Second Thought / (Xbox One Walkthrough) - Video

Freedom of the press in Commonwealth countries: How far should regulation go? – Video

Posted on by


Freedom of the press in Commonwealth countries: How far should regulation go?
On 14 January, in advance of its conference on Human Rights in the Modern Day Commonwealth, CPA UK held a panel discussion exploring the extent to which freedom of the press is regulated in...

By: Commonwealth Parliamentary Association UK

Read the original:

Freedom of the press in Commonwealth countries: How far should regulation go? - Video

Freedom Riders Ann Curthoys and Brian Aarons reflect on NSW Ride 50 years on

Posted on by

Fifty years ago, from February 12 to 26, 1965, Charles Perkins led a group of students, including us, from the University of Sydney on a freedom ride.

We travelled by bus to protest against racial discrimination against Aboriginal people in New South Wales country towns such as Walgett, Moree, Bowraville and Kempsey.

Although we had done our best to prepare, the non-Aboriginal students were shocked by what we found: desperately poor living conditions on fringe settlements, missions on which white managers controlled every aspect of Aboriginal people's lives, white people convinced of their racial superiority, and exclusion of Aboriginal people from the basic amenities of a country town.

So, we protested against the exclusion of Aboriginal people from RSL clubs in Walgett, swimming pools in Moree and Kempsey, and picture theatres in Bowraville.

The angry reaction of the white townsfolk to our protests made it clear to a broad Australian public that racial discrimination was alive and well, and led to some serious soul-searching in urban and rural NSW.

There were intense debates not only over the racial discrimination we exposed, but also over the truly dire situation of most Aboriginal people in gaining access to decent housing, health, and education.

The Freedom Ride was an important catalyst for some substantial changes in Aboriginal affairs over the next 10 years or so.

Significantly, it brought Charles Perkins to prominence as a passionate and articulate Aboriginal leader who was not afraid to tell white Australians just how disastrous their racism was for the lives and opportunities of his people.

As former freedom riders, we have been astounded at the huge interest in this anniversary - in the towns, in the university and in the media.

Today, a bus with current university students, university representatives, and original freedom riders is en route from the University of Sydney to Dubbo, Walgett, Moree, Bowraville, and Kempsey.

View original post here:

Freedom Riders Ann Curthoys and Brian Aarons reflect on NSW Ride 50 years on

I think it’s a connected car eco system Apple is working on and not a car – Video

Posted on by


I think it #39;s a connected car eco system Apple is working on and not a car
There is a lot of talk about that Apple is working on their own car, but personally I don #39;t believe that. They are just working on a connected car eco system that will control our cars in a...

By: Stefan Svartling

Originally posted here:

I think it's a connected car eco system Apple is working on and not a car - Video