CROI 2015 Meet the Young Investigators
Alex Medline, McGill University, Montreal, Quebec, CA; Nina Hosmane, Currently pursuing a PhD in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD;...
By: AccessHIV
Read the original:
Cells have two different programs to safeguard them from getting out of control and developing cancer. One of them is senescence (biological aging). It puts cancer cells into a permanent sleep so they no longer divide and grow in an uncontrolled way. Now the research group led by Professor Walter Birchmeier (Max Delbrck Center for Molecular Medicine, MDC, Berlin-Buch) has discovered that an enzyme known to be active in breast cancer and leukemia blocks this protection program and boosts tumor growth. They succeeded in blocking this enzyme in mice with breast cancer, thus reactivating senescence and stopping tumor growth (EMBO-Journal, DOI 10.15252/embj.201489004)*.
The enzyme Shp2 belongs to a group of enzymes called tyrosine phosphatases. These enzymes are major cell growth regulators. Shp2, for example, plays an essential role in early embryogenesis and is also known to play a role in cancer. Some years ago researchers showed that Shp2 is upregulated in 70 percent of invasive breast cancers. These forms of breast cancer are particularly aggressive. Recent studies with human breast cancer cell lines have also shown that Shp2 mediates survival signals in cancer cells.
Reason enough for MDC cancer researcher Professor Birchmeier, who for years has been studying signaling in cancer, to further investigate this enzyme with his research team colleagues Dr. Linxiang Lan and Dr. Jane Holland. Also, current evidence shows that senescence may play an inhibitory role in breast cancer.
The MDC researchers therefore studied mice which carried the breast cancer gene PyMT. This oncogene rapidly initiates breast cancer, which also metastasizes. The researchers noted that the enzyme Shp2 is very active in these mice. They were able to show that Shp2 initiates a signaling cascade. Within this cascade Shp2 turns on different signaling molecules, but turns off the tumor suppressor genes p27 und p53. As a result, the senescence protection program is also shut off.
The question of interest was whether or not senescence can be turned on again. Is it possible to target Shp2 directly and shut it off? Using a small molecule, researchers of the biotech company Experimental Pharmacology and Oncology (EPO), based on the Berlin-Buch campus as is the MDC, were able to shut down the Shp2 gene in the mice with breast cancer. In this way they were able to reactivate the senescence program and stop the growth of the breast cancer cells. The small molecule was developed by the Leibniz-Institut fr molekulare Pharmakologie (FMP) in Berlin-Buch. However, it is still an experimental drug and has not been licensed for use in human patients.
The next step was to find out which role Shp2 and its target genes play in human patients with breast cancer. Dr. Balzs Gyrffy of Semmelweiss University in Budapest, Hungary, a longtime collaborator of Professor Birchmeier, looked at the retrospective data of almost 4,000 patients. After analyzing the data, he and his collaborators in Berlin are convinced that the activity of Shp2 and its target genes can predict the outcome of breast cancer: The less active Shp2 is, the higher the chance for the affected women to stay relapse-free after having undergone a successful breast cancer therapy.
"Our data suggest that senescence induction by inhibiting Shp2 or controlling its targets may be useful in therapeutic approaches to breast cancer," the researchers conclude. Cancer cells in the senescence mode secrete messenger molecules of the immune system (cytokines), enabling the body's defense system to identify these sleeping cancer cells and destroy them.
###
*Shp2 Signaling is Essential to the Suppression of Senescence in PyMT-induced Mammary Gland Cancer in Mice Linxiang Lan1, Jane D. Holland1, Jingjing Qi1, Stefanie Grosskopf1, Regina Vogel1, Balzs Gyrffy2,3, Annika Wulf-Goldenberg4, Walter Birchmeier1,*
1 Cancer Research Program, Max Delbrck Center for Molecular Medicine (MDC) Berlin, Germany 2 MTA TTK Lendlet Cancer Biomarker Research Group, Budapest, Hungary 3 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary 4 Experimental Pharmacology & Oncology (EPO), Berlin, Germany
Read more here:
MDC cancer researchers identify new function in an old acquaintance
Microsoft is experimenting with peer-to-peer distribution for Windows 10 updates, potentially making the download process less agonizing.
According to The Vergeand Ars Technica,the latest leaked build of Windows 10 adds a Choose how you download updates section to the settings menu. This section has a toggle for downloading apps and updates from multiple sources to get them more quickly. Users can then choose to get apps and updates from other PCs on a local network, and from other computers on the Internet.
While the leak doesnt mention peer-to-peer technology specifically, The Verge notes that Microsoft acquired Pando Networks, a maker of P2P file sharing technology, in 2013. Its possible that this technology is playing a role in the new Windows 10 features.
If Microsoft goes ahead with this feature, itll likely have to provide some assurances on the security front, as peer-to-peer updates would be a disaster if attackers were somehow able to taint Windows updates. Users may also want to know what kind of responsibilities theyd shoulder on the upload side, in terms of how often theyd be seeding updates and drawing system resources.
Microsoft has gone nearly two months without delivering a new preview build for Windows 10, though the company may soon speed up the cycle for users who dont mind extra bugs. Between peer-to-peer updates and the first release of the Project Spartan web browser, the next build is shaping up to be a big one.
Why this matters: If youve ever tried to install a major Windows update on launch day, youve likely experienced the pain of sluggish downloads and server timeouts. A peer-to-peer system would solve that problem by taking a load off Microsofts servers, provided the company can make sure its software stays secure along the way.
Jared writes for PCWorld and TechHive from his remote outpost in Cincinnati. More by Jared Newman
Your message has been sent.
There was an error emailing this page.
More here:
Microsoft may speed up Windows updates with peer-to-peer distribution
Anti Aging Medicine 14 Nov. 2008 part 10
Anti Aging Medicine.
By: UI OViS
Read the original here:
THC OIL ORIGINAL MEDICINE
http://cannatheket.dk/ THC OLIE ER DET GTE SORTE GULD http://www.alternativ.info/doc/artikler/art2011_pje_hasholie.mv BRANDSRS HEALING MED THC OLIE MEDICINSK THC OLIE R ...
By: KolbyePlanet
Read the original:
Maternal and Fetal Medicine Clinic - UVA Health
The Maternal and Fetal Medicine Clinic at the University of Virginia Children #39;s Hospital provides total obstetric care for women of high risk and low risk.
By: WCAV CBS19
See the original post:
Class B Muslim Medicine and Math
By Savannah, Rachel M., Bethany.
By: Elizabeth Morgan
Continued here:
Jobs and altentative medicine
Steve jobs , homeopathy.
By: JUAN CA
Read the original post:
sylvia bagge "bold little planet" (album: release the medicine) copyright sylvia c. bagge.2000
This is the title track to Sylvia #39;s 2000 album, Bold Little Planet. Vocals, guitar, cello performed by Sylvia. The lyrics can be found below: the moon has been pretty patient with us tonight...
By: Sylvia Bagge
Read the original here:
Download #39;Future Of Medicine #39; for Adobe After Effects
Download here: http://goo.gl/70E7uD.
By: Out Of The Forest
Read more here:
Download 'Future Of Medicine' for Adobe After Effects - Video
UNSW Sports Medicine Society - Event #1
Live broadcasting of UNSW Sports Medicine Society #39;s educational events that immerse interstate, rural off-campus students into the room with our guest sports physicians! Our first event...
By: Education UNSW Sports Medicine Society
See the rest here:
Contact Information
Available for logged-in reporters only
Newswise PHILADELPHIA Thomas P. Cappola, MD, ScM, a physician-scientist with special expertise in heart failure, has been named chief of the division of Cardiovascular Medicine at the Perelman School of Medicine at the University of Pennsylvania.
He will lead a division comprised of 78 faculty and 47 fellows, overseeing both clinical care and research efforts across cardiovascular specialties, including interventional cardiology, electrophysiology, heart failure and transplantation, adult congenital heart disease, consultative cardiology, noninvasive imaging, preventive cardiology and vascular medicine. The division cares for more than 68,000 patients each year.
Dr. Cappola has proven himself to be a leader and innovator in cardiovascular medicine, particularly in his field of advanced heart failure and transplantation, said Michael S. Parmacek, MD, chair of the department of Medicine, who preceded Dr. Cappola as chief of the division of Cardiovascular Medicine. I look forward to watching him build upon the foundation of excellence in the division of Cardiovascular Medicine and taking the program in exciting new directions.
Cappola has served as an attending cardiologist on Penns nationally recognized advanced heart failure and transplantation service since his arrival at Penn in 2003. He also served as associate director of the Cardiovascular Medicine Fellowship Program from 2011 to 2013. That year, he was appointed as director of the Hospital of the University of Pennsylvania Clinical and Translational Research Center and assistant director of the Institute for Translational Medicine and Therapeutics (ITMAT). Dr. Cappola is also a member of Penns Institute for Diabetes, Obesity, and Metabolism; the Cardiovascular Institute; the Institute for Translational Medicine and Therapeutics; and the Penn Genome Frontiers Institute.
Dr. Cappolas application of genomic methodologies to identify the molecular and genetic basis of heart failure was recognized in 2008 with a Presidential Early Career Award for Scientists and Engineers (PECASE), which he received from President Obama. This is the highest honor bestowed by the United States government for scientists and engineers in the early stages of their careers. To date, Dr. Cappola has published over 80 manuscripts and lectured extensively nationally and internationally. Dr. Cappola currently serves as the co-principal investigator of the National Heart Lung and Blood Institute (NHLBI)-sponsored Mid-Atlantic Heart Failure Network. He is also co-investigator for the Institutional Clinical and Translational Science Award from the National Institutes of Health (NIH)/National Center for Advancing Translational Sciences (NCATS). Dr. Cappola is a member of the American Society of Clinical Investigation (ASCI) and the Interurban Clinical Club, and is a fellow of the American Heart Association.
Dr. Cappola earned his bachelors degree in chemistry at Princeton University in 1991, his medical degree at Harvard Medical School in 1995, and his masters degree of science in clinical investigation from the Bloomberg School of Public Health at Johns Hopkins University in 2004. He performed his internship and residency at Brigham and Womens Hospital and completed his cardiology fellowship, including specialty training in heart failure and transplantation, at Johns Hopkins.
###
Penn Medicine is one of the world's leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nation's first medical school) and the University of Pennsylvania Health System, which together form a $4.3 billion enterprise.
Read this article:
American College of Physicians celebrates 100th anniversary at Internal Medicine Meeting 2015, speakers include former US Senator Tom Daschle and Surgeon General Vivek Murthy
More than 6,000 internal medicine physicians, subspecialists, medical students, and allied health professionals from around the world will gather for the American College of Physicians' (ACP) Internal Medicine Meeting 2015 from April 30 through May 2 (Thursday - Saturday) at the Boston Convention and Exhibition Center.
More than 200 sessions cover a broad array of clinical and health care policy topics. On Thurs., April 30, former U.S. Senator Tom Daschle will give the keynote address at the Opening Ceremony, which begins at 9:30 a.m., and U.S. Surgeon General Vice Admiral (VADM) Vivek H. Murthy will address new Fellows at Convocation, which begins at 6:00 p.m.
Several special sessions highlight ACP's 100th anniversary, including:
ACP also will feature an art exhibit; a specially designed, large scale timeline of ACP history; a life-sized representation of Sir William Osler, the "Father of Internal Medicine," for attendees to snap a 'selfie' with; and a centennial-themed video to kick off the Opening Ceremony.
Internal Medicine Meeting 2015 includes national abstract competitions for Medical Students and Resident/Fellow members. Finalists will compete onsite in five categories: Clinical Vignette, Basic Research, Clinical Research, Quality Improvement - Patient Safety, and High Value Care. Resident/Fellow oral presentations take place on May 1. Medical Student oral presentations will take place on May 2. Winners of the poster competitions will be announced on May 2 at 6:30 p.m.
On May 2 at 5:15 p.m., Internal Medicine Meeting Highlights and the final round of Doctor's Dilemma take place. Clinician-educators will share what they think are the meeting's most important take-home messages. Then the "Final Four" teams remaining in the Doctor's Dilemma competition -- a fast-paced, Jeopardy-style medical knowledge competition among students and residents -- will face off in the championship round. The winning team takes home the Osler Cup -- ACP's coveted trophy.
During the meeting, Wayne J. Riley, MD, MACP, will become president of ACP and Tanveer P. Mir, MD, MACP, will become chair of ACP's Board of Regents. Both terms are for one year.
###
Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.
See more here:
Largest medical specialty organization in US meets to present latest advances in internal medicine
PRESS RELEASE: True Leaf Medicine International Ltd.: Listing on German Stock Exchanges
DGAP-News: True Leaf Medicine International Ltd. / Key word(s): IPO/Miscellaneous True Leaf Medicine International Ltd.: Listing on German Stock Exchanges
2015-03-16 / 13:15
=--------------------------------------------------------------------
True Leaf Medicine Announces Listing on German Stock Exchanges
True Leaf Medicine International Ltd. (CSE: MJ) (Germany: TLA; WKN: A14NM1) ("True Leaf") wishes to announce that its common shares are now listed and trading on the German stock exchanges in Frankfurt, Berlin and Munich under the symbol TLA. True Leaf anticipates that this listing will provide the company with increased visibility for its activities in all European capital markets.
True Leaf has appointed Bank M as its designated sponsor on the Frankfurt Stock Exchange. Designated sponsors secure higher liquidity and a better pricing by quoting binding prices for buying and selling shares on the electronic trading platform XETRA"
Darcy Bomford, President of True Leaf stated, "We are excited by this new listing as we anticipate the European investment community will have a large appetite for our unique Quality of Life vision for both people and pets."
As True Leaf awaits the approval of its license application, the company is looking to enter the pet industry with a line of pet products focused on hemp nutrition, in conjunction with the development of a veterinary-approved cannabis-based pet medication.
The ISIN number for True Leaf is CA89785C1077 and the German Security Code (WKN) is A14NM1.
Go here to see the original:
PRESS RELEASE: True Leaf Medicine International Ltd.: Listing on German Stock Exchanges
Your M-Home at the University of Michigan Medical School
As healthcare delivery modes change and our base of scientific knowledge exponentially expands, our methods for training students to develop the skills neces...
By: UMHealthSystem
Read this article:
Your M-Home at the University of Michigan Medical School - Video
Davao Medical School Foundation - Admission 2015 @ +91 9442244576
Davao Medical School Foundation offers MBBS at affordable prices, Mr.Subas Chandra Bose - Director of St.John #39;s EDUCARE, Explain all the details like Fee Str...
By: Davao Medical School Foundation
Go here to see the original:
Davao Medical School Foundation - Admission 2015 @ +91 9442244576 - Video
Recent results published in U.S. News and World Report demonstrate that East Carolina Universitys graduate programs, especially in medical fields, are among the best in the nation.
ECUs Brody School of Medicine ranks 25th in the nation in preparing physicians for primary care. For perspective, UNC-Chapel Hill ranked second and Duke University ranked 29th in the same category.
Just as important, if not more so, is the fact nearly 60 percent of Brody graduates remain in primary care five years after graduation the highest in the state. Nearly one in five of Brodys 2,198 graduates practice in Eastern North Carolina. These figures show ECUs medical school is fulfilling its primary mission of improving health care in or in part of the state.
The rehabilitation counseling program in the College of Allied Health Sciences Department of Addictions and Rehabilitation Studies is ranked 18th among such programs by U.S. News. ECU offers a masters degree in rehabilitation and career counseling and substance abuse and clinical counseling.
Students also can pursue certificates in rehabilitation counseling, substance abuse counseling, vocational evaluation and military and trauma counseling. The doctoral program in rehabilitation counseling and administration allows students to specialize in substance and clinical counseling, vocational evaluation or rehabilitation research.
The ECU College of Nursing also made a strong showing, ranking 83rd among the nations best graduate nursing programs and 18th among online graduate nursing programs. ECUs College of Nursing graduates more nursing students than any school of nursing in North Carolina.
The masters of science in nursing program prepares students for advanced roles as clinical nurse specialists, neonatal nurse practitioners, nurse anesthetists, nurse midwives, nurse educators and nurse administrators.
Adult-gerontology nurse practitioner and family nurse practitioner options have transitioned to the doctoral of nursing degree program. The Doctor of Nursing Practice and the Doctor of Philosophy in Nursing are the terminal degree programs offered at ECU.
U.S. News graduate school rankings for 2016 also listed ECUs physician assistant studies program at 70th.
Founded on March 8, 1907, East Carolina began as East Carolina Teacher Training School (ECTTS), a normal school to prepare teachers. Classes began on Oct. 5, 1909, on the 43-acre campus. In 1920, the school became East Carolina Teachers College ECTC. In 1951, the school was renamed East Carolina College. In 1968, the school became a full-fledged university.
View post:
Mike Parker: East Carolina programs ranked among nations best
Industry Media Arts Jackson Liberty High School Film Challenge #2- Forgotten
Music by Thomas Doeve WE DO NOT OWN THE MUSIC IN THIS FILM. Filmed for the Jackson Film Festival. Directed by Jordan Goldstein. Director of Photography David Cutler. Edited by Me. Written...
By: Robin TheBoyWeirdo
See the original post:
Industry Media Arts Jackson Liberty High School Film Challenge #2- Forgotten - Video
Liberty Radio Ohio - 3/14/2015
Political talk for liberty-minded Buckeyes with Bill Yarbrough and Scott Pettigrew This episode we tackled Oklahoma #39;s marriage law, SAE racism, Rand Paul #39;s possible gaffes, and marijuana law...
By: Liberty Radio Ohio
View post:
Backyard Liberty Aquaponics Video Package Download
Backyard Liberty members area login info: http://tinyurl.com/BackyardLibertyDownloadBookPDF Use Your Voucher Now And You Will Achieve Total Food Independence In Less Than 28 Days.
By: Conte Mueller
View post: