Meet Dr. Pamela Warnick, Infectious Desease - Advocate Health Care
Learn about how Dr. Pamela Warnick, Infectious Disease at Advocate Illinois Masonic Medical Center in Chicago treats all patients with respect and compassion.
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Meet Dr. Pamela Warnick, Infectious Desease - Advocate Health Care - Video
Institutionalized: Mental Health Behind Bars
America #39;s relationship with its mentally ill population continues to suffer as a result of inadequacies in the country #39;s mental health care system. For the mentally ill in Chicago, the...
By: VICE News
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This Week On The Line (Trailer): Danny Gold Discusses Chicago #39;s Mental Health Crisis
On Thursday at 12pm EDT Danny Gold will join #39;On the Line #39; to discuss his new piece on America #39;s mental health care crisis, "Institutionalized: Mental Health Behind Bars" - http://bit.ly/1DHIqYj...
By: VICE News
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This Week On The Line (Trailer): Danny Gold Discusses Chicago's Mental Health Crisis - Video
Jiu jitsu which means gentle or soft art is formerly from Japan. At the first time, Jiu Jitsu was practiced by samurai without using Gi or Jiu Jitsus uniform. Jiu jitsu is an interesting kind of martial art. However, Jiu Jitsu is not like other common martial arts, such as Judo, Tae Kwon Do, and Karate. Those kinds of martial arts use power to defeat the enemy or the attacker, but Jiu Jitsu uses balance to defeat from the enemy. The technique which is stressed in Jiu Jitsu is grappling. This grappling technique includes joint-locks, holds, trapping, choking, strangling, gouging, etc. also, Jiu Jitsu has defensive technique.
Because of its development, Jiu Jitsu then developed in other countries outside Japan. United States is one of the countries which also learn Jiu Jitsu. For instance, you can find Jiu Jitsu in Charlotte, the largest city in North Carolina. For you who want to learn Jiu Jitsu, do not have to worry because you can join Jiu Jitsu Classes in Charlotte.
Besides its interest as a kind of martial arts, Jiu Jitsu also has some benefits you can get. You have to know that Jiu Jitsu can teach you how to escape from gripping. As you know, crime often happened in any places unpredictably. The first thing that you may think is to get away from someone who wants to attack you. Unfortunately, he may grip you before you have a chance to escape. With the help of Jiu Jitsus technique, you can learn how to escape. Moreover, you can learn how to make your enemy or attacker immobilize without hurting him/ her. Other benefits are that you can learn the different ways of time managements.
Not only Karate and Tae Kwon Do have belts, but Jiu Jitsu also has belts. The belts in Jiu Jitsu are divided into junior and senior belts. Junior belts are used by people who are no more than sixteen years old, while the senior belts are used by people who are more than sixteen years old. Moreover, the highest belt is the red belt.
Finally, learning this kind of martial arts is very interesting. You can get many benefits of training Jiu Jitsu. By learning the right techniques of Jiu Jitsu, you will get the benefits of learning Jiu Jitsu.
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IMAGE:Nucleic Acid Therapeutics is an authoritative peer-reviewed journal published bimonthly in print and online that focuses on cutting-edge basic research, therapeutic applications, and drug development using nucleic acids or related... view more
Credit: Mary Ann Liebert, Inc., publishers
New Rochelle, NY, April 7, 2015--An experimental single-stranded oligonucleotide-based drug, MGN1703, comprised only of natural DNA components, stimulates the human immune system to fight infections and attack cancer cells without causing the harmful side effects associated with similar compounds that also contain non-natural DNA components. The design and structural characteristics of MGN1703, which is in clinical testing to treat a variety of cancers, affect its potency and toxicity, as described in an article in Nucleic Acid Therapeutics, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers . The article is available free on the Nucleic Acid Therapeutics website until April 24th, 2015.
"Design and Structural Requirements of the Potent and Safe TLR-9 Agonistic Immunomodulator MGN1703" presents a detailed look at this DNA molecule, which contains non-methylated cytosine nucleotides in cytosine-guanine pairs, a signature often found in bacteria and viruses that sends a danger signal to human immune cells. These compounds bind to and activate toll-like receptor 9 (TLR9), triggering a cascade of signaling pathways in the immune system that enable recognition and destruction of foreign cells.
Manuel Schmidt and Matthias Schroff, Mologen AG (Berlin, Germany), Nicole Hagner and Burghardt Wittig, Freie Universitaet Berlin, Alberto Marco, Universidad Autonoma de Barcelona (Spain), and Sven Knig-Merediz, Vivotecnia (Madrid, Spain) describe their approach to the molecular design of MGN1703. They avoided the need to incorporate non-natural components into the DNA backbone to enhance its potency and stability by instead manipulating its size and shape.
"Moving forward to solve the concerns and disappointment of clinical implementation of cytosine-phosphodiester-guanine oligodeoxynucleotides, this work is an important step towards the application of a new class of safe and efficacious immunomodulators in humans," says Executive Editor Graham C. Parker, PhD, The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Children's Hospital of Michigan, Detroit, MI.
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About the Journal
Nucleic Acid Therapeutics is an authoritative peer-reviewed journal published bimonthly in print and online that focuses on cutting-edge basic research, therapeutic applications, and drug development using nucleic acids or related compounds to alter gene expression. The Journal is under the editorial leadership of Editor-in-Chief Bruce A. Sullenger, PhD, Duke Translational Research Institute, Duke University Medical Center, Durham, NC, and Executive Editor Graham C. Parker, PhD. Nucleic Acid Therapeutics is the official journal of the Oligonucleotide Therapeutics Society. Complete tables of content and a sample issue may be viewed on the Nucleic Acid Therapeutics website.
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New, natural DNA-based drugs are safe, potent activators of immune system
PBR Staff Writer Published 07 April 2015
Bristol-Myers Squibb (BMS) and Netherlands-based uniQure have entered into exclusive strategic collaboration to develop gene therapies for cardiovascular diseases.
The deal will give BMS exclusive access to uniQure's gene therapy technology platform for the development of new treatments.
The companies will collaborate on up to ten targets, mostly concentrating on cardiovascular therapies, such as a treatment to reinvigorate congestive heart failure patients' ability to synthesize S100A1.
The Dutch firm will lead discovery efforts and clinical manufacturing, while BMS will fund the research, lead development and regulatory activities as well as have sole commercialization rights under the deal.
Bristol-Myers Squibb Discovery R&D head Carl Decicco said: "Bristol-Myers Squibb has an excellent and long-standing track record of success in discovering and developing treatments for cardiovascular diseases and in embracing advancing technologies for the treatment of human diseases.
"Collaborating with uniQure, a clear leader in the field with an innovative and validated gene therapy platform, further strengthens our capability to bring forward transformational new therapeutics for difficult-to-treat diseases, including cardiovascular diseases such as heart failure."
As part of the deal, BMS will pay $50m upfront and $100m total in the near-term, and the company will gain a sizeable stake in uniQure with options to but even more equity.
In addition, uniQure will receive R&D and milestone payments of $254m for the first main therapy and up to $217m for each of the other therapies.
uniQure chief executive officer Joern Aldag said: "Bristol-Myers Squibb's strength in the cardiovascular area and its commitment to gene therapy will allow them to leverage the full breadth and capacity of our platform for cardiovascular diseases.
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Bristol-Myers, uniQure enter cardiovascular gene therapy deal
CONSUMERS come from Planet Price or Planet Story, Telstra futurist Michael Ossipoff told the Northern Territory Cattlemen's Association (NTCA) conference in Darwin last month.
The red meat industrys Target 100 program communicates with those on Planet Story. As it reaches its third birthday, the program, showcasing progress by cattle and sheep farmers and researchers towards 100 sustainability goals, has put together some statistics about its reach.
Target 100 has completed over 90 research and development projects, accumulated 230-plus producer case studies, created over 80 YouTube videos, enticed over 10,000 Facebook followers, developed 10 curriculum-aligned resources for schools, reached two million Aussies through cinema ads and shared the story of Australian beef and lamb producers with 20,000 urban consumers at events across the country, the program reported in its latest newsletter.
A more recent initiative has been Target 100 Responds, a section of the Target 100 website dedicated to addressing criticisms of the red meat industries.
The necessity to address criticism came up last year, when the US-made movie Cowspiracy: The Sustainability Secret came to Australia. The movie claimed to uncover a conspiracy against the environment by the beef industry.
Target 100 addressed the movies claims at length, and in measured tones.
It noted that Australian beef production systems are not like those in the US, do not produce any clearing in the Amazon, and that the industry has a range of active research projects looking at reducing greenhouse gas emissions and other aspects of its environmental footprint.
Target 100 has its own comprehensive website, a presence on Facebook, Twitter and YouTube.
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Calvin Harris - Summer (Filous Kitty Gorgi Cover)
Calvin Harris - Summer (Filous Kitty Gorgi Cover) Subscribe to Futurism: http://full.sc/1LghY97 SHOW MORE for the download link + more! Download Calvin Harris - Summer (Filous ...
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Prophecy Interpretation: Preterism, Futurism or Historicism?
How do we need to interpret prophecy? In this video you will learn about preterism, futurism and historicism, apocalyptic and classical prophecy as well as chiasm. This is part 2 in a series...
By: Empower Missions
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Prophecy Interpretation: Preterism, Futurism or Historicism? - Video
Is Freedom of Speech being suppressed in the West
By: jonny kzj
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Why was Indiana #39;s #39;religious freedom #39; law needed?
People are still up in arms about Indiana #39;s Religious Freedom Restoration Act. Before being "fixed" last week, the law allowed private businesses to deny service to some customers, namely members...
By: HLN
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Financial Freedom " MILLIONAIRE #39;S MINDSET by JP Peralta"
Have you ever wondered how millionaires became millionaires? What #39;s their secret? Perhaps you keep asking yourself, when will I ever earn my million? Will I ever earn a million in my lifetime?...
By: JP Peralta
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Financial Freedom " MILLIONAIRE'S MINDSET by JP Peralta" - Video
Freedom! network #39;s intro #2
Freedom! network #39;s intro #2 --------------------------------------------- Like , Comment , Subscribe !! --------------------------------------------- regards, Aditya.
By: AdityaArts
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Religious Freedom in Indiana Attacked By Famous, Rich Liberals | ZoNation
Famous, rich, wealthy, influential liberals, from Cher to Kareem Jabbar using their status to oppose RFRA. They #39;re cultural icons, who #39;s backward world view is valued by millions. Also here #39;s...
By: PJ Media
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Religious Freedom in Indiana Attacked By Famous, Rich Liberals | ZoNation - Video
Dr. Rand Paul on Internet Freedom
A revolution is occurring around the world. It is occurring in the private sector, not the public sector. The technology revolution has created vast new markets where none previously existed....
By: Rand Paul
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"SURFER EXO" - NOW AVAILABLE - Get The Surfer Exo For Free (AW MICRO DLC)
I am Partnered with Freedom TV check them out at: http://www.freedom.tm/ Go get the surfer exo guys! 😀 Second Channel: https://www.youtube.com/channel/UCkm1Cv2oQN_LG6KskatnXFQ Wanna Join ...
By: ItsInnocent - Call Of Duty GTA V
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"SURFER EXO" - NOW AVAILABLE - Get The Surfer Exo For Free (AW MICRO DLC) - Video
Radio Webcast: Religious Freedom Talk: WGSO-Bayoubuzz Webcast
Radio Webcast: Religious Freedom Talk--Segment of WGSO radio and Bayoubuzz Google Hangout Webcast with Jeff Crouere and Stephen Sabludowsky. Discussion focused upon implications of ...
By: Stephen Sabludowsky
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Radio Webcast: Religious Freedom Talk: WGSO-Bayoubuzz Webcast - Video
Freedom Minute | Burning the Constitution
Energy Policy Center Director Amy Oliver Cooke warns of the EPA #39;s "Clean Power Plan." A plan with such destructive implications, even some of the Left are speaking out against it.
By: IITV
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What Just Happened to Religious Freedom? | CitizenLink Report
Indiana enacted a solid Religious Freedom Restoration Act. But a howl of protest from the left succeeded in getting lawmakers to modify it. What just happened? And what can we learn from it?...
By: CitizenLink.com
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What Just Happened to Religious Freedom? | CitizenLink Report - Video
Top Indiana Republican lawmakers overhauled their week-old religious freedom law Thursday with a follow-up measure intended to ease concerns driven by businesses that it could lead to discrimination. Gov. Mike Pence then signed it into law.
The changes appear to have tamped down some of the criticism -- but in doing so Pence and lawmakers infuriated social conservative activists and set the stage for a bigger fight next year over expanding Indiana's anti-discrimination law to cover gays and lesbians.
Republican legislative leaders unveiled their series of changes Thursday morning to the law that triggered intense backlash from businesses, sports associations, pro-LGBT groups and even fiscally-focused conservatives when Pence signed it last week.
The GOP-dominated House and Senate approved a legislative fix, which was added into an unrelated bill, on Thursday, sending it to Pence's desk almost immediately.
Despite last-minute lobbying from conservative groups like Indiana Right to Life to get Pence to veto the fix, the governor signed it Thursday evening.
"In the midst of this furious debate, I have prayed earnestly for wisdom and compassion, and I have felt the prayers of people across this state and across this nation. For that I will be forever grateful," Pence said in a statement.
"There will be some who think this legislation goes too far and some who think it does not go far enough, but as governor I must always put the interest of our state first and ask myself every day, 'What is best for Indiana?'" he said. "I believe resolving this controversy and making clear that every person feels welcome and respected in our state is best for Indiana."
The changes prohibit businesses from using the law as a defense in court for refusing "to offer or provide services, facilities, use of public accommodations, goods, employment, or housing" to any customers based on "race, color, religion, ancestry, age, national origin, disability, sex, sexual orientation, gender identity, or United States military service."
It doesn't accomplish what the law's critics wanted most: Adding sexual orientation to the list of categories protected by Indiana's anti-discrimination law.
But that debate, GOP legislators acknowledged, is coming soon. House Speaker Brian Bosma said the backlash against the religious freedom law has "opened many perspectives" and that the anti-discrimination law "needs to be discussed."
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