Mesoblast takes partnership with Celgene, shares rise 27pc

Mesoblast chief executive Silviu Itescu says new strategic partner Celgene has a "strong franchise and sales and marketing. Photo: Josh Robenstone

Mesoblast chief executive Silviu Itescu says a $58.5 million investment from pharmaceutical giant Celgene gives the company a strong potential route to market as the stem cell therapy developernears its first sales.

The American giant Celgene, which had revenue of $US7.7 billion ($10 billion) from treatments for cancers and inflammatory diseases like psoriasis, picked up 15.3 million shares at $3.82 a share. Investors welcomed the deal, pushing the volatile stock up 24 per cent to $3.99 on Monday.

The surge boosted the value of Mr Itescu's 22 per cent stake in the company by $53 million to $272 million.

Mesoblast shares have lost about 16 per cent in the past year, compared with a 10 per cent rise in the benchmark S&P/ASX 200 index.

The stock last traded at the placement price a month ago, but has traded as high as $5.75 in the past year. Mr Itescu said Mesoblast and Celgene began talks about six months ago. He described the deal as "a fair transaction".

"The right time is when you come to an arrangement with a strategic partner," he said. "Where the share price is at any given time is much less relevant to the value of the technology and the partnership."

As part of the deal, which gives Celgene a stake of about 4.5 per cent, the company will have first right of refusal over licensing deals for the commercialisation of Mesoblast's adult stem cell products in the treatment of certain diseases.

That is, if Mesoblast is approached by another company to licence itsdrug candidates for the prevention and treatment of acute graft versus host disease (GVHD), certain oncologic diseases, inflammatory bowel diseases, and organ transplant rejection, Celgene will have six months in which it can mull whether it would like to trump the deal.

Mr Itescu said Celgene has a "strong franchise and sales and marketing capability" in cancer and inflammatory diseases. He said Mesoblast's candidate for the treatment of graft versus host disease, a common complication of bone marrow transplants used to treat cancer, "fits perfectly well into their cancer and oncology franchise."

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Mesoblast takes partnership with Celgene, shares rise 27pc

Baba Nam Kevalam – Thoughts of PR Sarkar – Spirituality & Determination – Video


Baba Nam Kevalam - Thoughts of PR Sarkar - Spirituality Determination
Baba Nam Kevalam, this is a mahamantra, or a universal mantra given by shrii PR Sarkar, in order to concentrate and liberate the mind from the superficial level and elevate it to the super...

By: AMPS0521

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Baba Nam Kevalam - Thoughts of PR Sarkar - Spirituality & Determination - Video

Ep. 63: Character Refinement; Non-Jewish Spirituality; Chassidus Applied to Counting the Omer – Video


Ep. 63: Character Refinement; Non-Jewish Spirituality; Chassidus Applied to Counting the Omer
Addressing the Personal and Emotional Needs of Our Community and Answering the Most Pressing Questions of Our Lives -- from the Perspective of Chassidic Thought. Topics: Where is the...

By: Meaningfullife

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Ep. 63: Character Refinement; Non-Jewish Spirituality; Chassidus Applied to Counting the Omer - Video

Salon sessions and cinema screenings on offer at care home

The new Karuna Manor care home, in Christchurch Avenue, Kenton

The new Karuna Manor care home, in Christchurch Avenue, Kenton

The new Karuna Manor care home, in Christchurch Avenue, Kenton

The new Karuna Manor care home, in Christchurch Avenue, Kenton

The new Karuna Manor care home, in Christchurch Avenue, Kenton

The new Karuna Manor care home, in Christchurch Avenue, Kenton

First published in News by Victoria Oliphant, Reporter

Front row seats to the latest blockbusters are on offer to residents living at a new care home.

The in-house cinema is one of a range of unique activities available atKaruna Manor care home, in Christchurch Avenue, Kenton.

Residentscan alsovisit priests in the temple, participate in activities from yoga to kerrum, or take a stroll through the gardens.

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Salon sessions and cinema screenings on offer at care home

My friend, the tax collector

In the height of tax season here in the US, Im reminded of the Bible story about a man named Zacchus, who was a tax collector a publican in Jericho. Its likely that he didnt have many friends. Tax collectors in biblical times were not popular. The system was corrupt. The collector could set a rate higher than the Roman government required, and the higher the rate the more money he could keep for himself. Zacchus was a rich man, so evidently he had done very well for himself, but through questionable means.

One day, Christ Jesus was traveling through Jericho. Zacchus desire to catch just a glimpse of that holy man was so great that he climbed a sycamore tree to see over the crowd. When Jesus singled him out to tell him that he must spend time at his house that day, Zacchus received him joyfully and not only this. Zacchus was so inspired by Jesus recognition of him that he vowed to give half his wealth to those who needed it. He even promised to repay fourfold everything he had taken dishonestly (see Luke 19:1-9).

Such a profound change in character indicates to me that the dawning of Christly enlightenment in individual thought brings an enrichment of meaning and purpose into our lives that nothing else can. It opens a range of opportunities to love and help others. We begin to find treasures of spiritual qualities in ourselves and our fellow man that we may not have seen before.

The issue is not about how rich we are, nor what our background includes. Its about the kind of change Zacchus experienced. The Scriptures and their companion book, Science and Health with Key to the Scriptures by Mary Baker Eddy, who founded this newspaper and Christian Science, show the relevance of the story of Zacchus today. A thoughtful study of these books reveals that the Christ, the divine nature which is expressed in man, Gods image and likeness is always with us. We comprehend man made in Gods likeness as we grow in our understanding of Gods nature of pure goodness. Our encounter with the holy presence of the Christ comes today in the form of transforming spiritual inspiration.

Understanding, even in a degree, mans spiritual identity and individuality lifts us above worldly fears, furies, and frustrations. With Zacchus, it started with a desire to see Jesus, but he was really being drawn to the transforming influence of the Christ, which Jesus represented. His first step was to climb upward to see above the crowd, and later as he stood in the presence of Jesus, his life was profoundly transformed. The change was not so much self-improvement as it was self-discovery. Jesus recognition of him as a loved, pure child of God allowed him to recognize his own value and worth as Gods expression.

Sometimes, whether in the midst of material wealth or lack, our hearts yearn to know we are loved and valued. But we, too, can take that first step that lifts us above the crowds of fear and limitation, and begin to glimpse mans true God-given nature. It may appear as a change of character, but its really mans innate Christlike nature becoming apparent. A new you which is the forever you that God created is emerging. Self-improvement is good, but self-discovery is infinitely better. And anyone who shows by example what it means to feel this enriching, transforming touch of Christ, like Zacchus, is someone I would be glad to call a friend.

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My friend, the tax collector

Stunning Views of Earth From the International Space Station | Out There | The New York Times – Video


Stunning Views of Earth From the International Space Station | Out There | The New York Times
The International Space Station is as far as humans go in space these days, but it is at just the right distance to capture astonishing images of Earth. Produced by: Dennis Overbye, Jonathan...

By: The New York Times

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Stunning Views of Earth From the International Space Station | Out There | The New York Times - Video

Space station grocery run includes Italian espresso maker

CAPE CANAVERAL, Fla. (AP) Mornings are about to improve for the Italian astronaut who's been suffering through instant coffee at the International Space Station since fall. An espresso machine is on the supply capsule scheduled for launch Monday.

SpaceX has a single second at precisely 4:33 p.m. to launch its unmanned cargo ship for NASA from Cape Canaveral, Florida. Forecasters put the odds of acceptable weather at 60 percent, with thick storm clouds the main concern.

Minutes after liftoff, SpaceX will try again to land its leftover booster on an ocean barge.

This will be the company's third attempt to fly a first-stage booster to a platform floating off Florida's east coast and land it vertically. The January effort ended in flames when the booster tumbled off the platform; February's attempt was nixed because of rough seas.

The platform, dubbed "Just Read the Instructions," can hold position better now, thanks to improvements, and the rocket's steering system should have plenty of hydraulic fluid for touchdown. That's why Hans Koenigsmann, a SpaceX vice president, is predicting 75 percent or even 80 percent odds of success this time.

The California company led by billionaire Elon Musk wants to save money by reusing rockets.

"The implications are huge and, of course, in the long term this might change completely how we approach transportation to space," Koenigsmann said.

The specially designed, Italian-made espresso maker is intended for Samantha Cristoforetti, who arrived last November. It was supposed to fly in January, but ended up on backlog following another company's launch explosion last year.

Altogether, the SpaceX capsule, named Dragon, holds more than 4,000 pounds of food, science experiments and equipment.

___

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Space station grocery run includes Italian espresso maker

Finally, a place to get a good cup of coffee in space

The next space station grocery run will carry caffeine to a whole new level: Aboard the SpaceX supply ship is an authentic espresso machine straight from Italy.

SpaceX is scheduled to launch its unmanned rocket with the espresso maker - and 4,000 pounds of food, science research and other equipment - Monday afternoon.

The experimental espresso machine is intended for International Space Station astronaut Samantha Cristoforetti of Italy. It was supposed to arrive in January, shortly after her arrival, so she could get some relief from the station's instant coffee. But it ended up on the back burner after a station shipment from Virginia was lost in a launch explosion.

The espresso maker is dubbed ISSpresso - ISS standing for International Space Station. Italian coffee giant Lavazza joined forces with the Turin-based engineering company Argotec and the Italian Space Agency to provide a specially designed machine for use off the planet. NASA certified its safety.

NASA's space station program deputy manager, Dan Hartman, said it's all part of making astronauts feel at home as they spend months - and even up to a year - in orbit. Already, Mission Control gives astronauts full access to email, phone calls, private video hookups, and live news and sports broadcasts.

"The psychological support is very, very important," Hartman told reporters Sunday. "If an espresso machine comes back and we get a lot of great comments from the crew ... It's kind of like the ice cream thing, right, when we fly ice cream every now and then. It's just to boost spirits. Maybe some rough day, a scoop of ice cream gets them over that hump kind of thing."

The SpaceX Dragon supply ship also holds experiments for NASA's one-year space station resident Scott Kelly, who moved in a couple weeks ago. Russian cosmonaut Mikhail Kornienko also will remain on board until March 2016.

This will be the California-based SpaceX company's seventh station supply run since 2012, all from Cape Canaveral.

For the third time, SpaceX will attempt to land its leftover booster vertically on an ocean barge. Both previous tests failed.

Improvements to the first-stage booster and floating platform - based on lessons learned from the January and February attempts - should boost the odds of success this time to 75 percent or maybe 80 percent, said Hans Koenigsmann, vice president of mission assurance for SpaceX.

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Finally, a place to get a good cup of coffee in space

Space station to finally get its Italian espresso machine

CAPE CANAVERAL, Fla. The next space station grocery run will carry caffeine to a whole new level: Aboard the SpaceX supply ship is an authentic espresso machine straight from Italy.

SpaceX is scheduled to launch its unmanned rocket with the espresso maker and 4,000 pounds of food, science research and other equipment Monday afternoon.

The experimental espresso machine is intended for International Space Station astronaut Samantha Cristoforetti of Italy. It was supposed to arrive in January, shortly after her arrival. It ended up on the back burner after a station shipment from Virginia was lost in a launch explosion.

The espresso maker is dubbed ISSpresso ISS standing for International Space Station. Italian coffee giant Lavazza joined forces with the Turin-based engineering company Argotec and the Italian Space Agency to provide a specially designed machine for use off the planet. NASA certified its safety.

For the third time, SpaceX will attempt to land its leftover booster vertically on an ocean barge. Both previous tests failed.

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Space station to finally get its Italian espresso machine

Espresso maker space mission

This undated product image made from video provided by Lavazza shows a prototype of Lavazza and Argotec's "ISSpresso" machine. The final version will be the first real Italian espresso machine on The International Space Station. On Monday, April 13, 2015, a version of the coffee maker is scheduled for launch to the International Space Station aboard a supply capsule. (AP Photo/Lavazza)(The Associated Press)

This undated product image provided by Lavazza, shows a prototype of Lavazza and Argotec's "ISSpresso" machine. The final version will be the first real Italian espresso machine on The International Space Station. On Monday, April 13, 2015, a version of the coffee maker is scheduled for launch to the International Space Station aboard a supply capsule. (AP Photo/Lavazza)(The Associated Press)

CAPE CANAVERAL, Fla. The next space station grocery run will carry caffeine to a whole new level: Aboard the SpaceX supply ship is an authentic espresso machine straight from Italy.

SpaceX is scheduled to launch its unmanned rocket with the espresso maker and 4,000 pounds of food and other equipment Monday afternoon. Forecasters put the weather odds at 60 percent.

The experimental espresso machine is intended for International Space Station astronaut Samantha Cristoforetti of Italy. It was supposed to arrive in January, shortly after her arrival, so she could get some relief from the station's instant coffee. But it ended up on the back burner after a station shipment was lost in a launch explosion.

For the third time, SpaceX will attempt to land its leftover booster on an ocean barge.

See the article here:

Espresso maker space mission