Why Should a Libertarian Take Universal Basic Income Seriously? – Niskanen Center (press release) (blog)

February 6, 2017 by Edwin G. Dolan

Edwin G. Dolan is an economist and educator whose writings regularly appear at EconoMonitor.The Niskanen Center is excited to welcome him as a new Poverty and Welfare adjunct focusing on Universal Basic Income research.

In recent post on EconLog, Bryan Caplan writes, Im baffled that anyone with libertarian sympathies takes the UBI [universal basic income] seriously. I love a challenge. Let me try to un-baffle you, Bryan, and the many others who might be as puzzled as you are. Here are three kinds of libertarians who might take a UBI very seriously indeed.

Libertarian pragmatists

Philosophical issues aside, what galls many libertarians most about government is the failure of many policies to produce their intended results. Poverty policy is Exhibit A. By some calculations, the government already spends enough on poverty programs to raise all low-income families to the official poverty level, even though the poverty rate barely budges from year to year. Wouldnt it be better to spend that money in a way that helps poor people more effectively?

A UBI would help by ending the way benefit reductions and welfare cliffs in current programs undermine work incentives. When you add together the effects of SNAP, TANF, CHIP, EITC and the rest of the alphabet soup, and account for work-related expenses like transportation and child care, a worker from a poor household can end up taking home nothing, even from a full-time job. A UBI has no benefit reductions. You get it whether you work or not, so you keep every added dollar you earn (income and payroll taxes excepted, and these are low for the poor).

But, wait, you might say. Why would I work at all if you gave me a UBI? That might be a problem if you got your UBI on top of existing programs, but if it replaced those programs, work incentives would be strengthened, not weakened. In which situation would you be more likely to take a job: one where you get $800 a month as a UBI plus a chance to earn another $800 from a job, all of which you can keep, or one where your get $800 a month in food stamps and housing vouchers, and anything extra you earn is taken away in benefit reductions?

Or, you might say, a UBI might be fine for the poor, but wouldnt it be unaffordable to give it to the middle class and the rich as well? Yes, if you added it on top of all the middle-class welfare and tax loopholes for the rich that we have now. No, if the UBI replaced existing tax preferences and other programs that we now lavish on middle- and upper-income households. Done properly, a UBI would streamline the entire system of federal taxes and transfers without any aggregate impact on the federal budget.

Classical liberals

Not all of those with libertarian sympathies are anarcho-capitalist purists. Many classical liberals, even those whom purist libertarians lionize in other contexts, are more open to the idea of a social safety net as a legitimate function of a limited government.

In his book Law, Legislation, and Liberty, classical liberal Friedrich Hayek wrote,

The assurance of a certain minimum income for everyone, or a sort of floor below which nobody need fall even when he is unable to provide for himself, appears not only to be a wholly legitimate protection against a risk common to all, but a necessary part of the Great Society.

Philosophically, classical liberals see social insurance of this kind as something to which they would willingly assent if they considered it behind a veil of ignorance, where they did not know if they themselves would be born rich or poor. Once the philosophical hurdle is overcome, the practical advantages of a UBI become highly attractive. In terms of administrative efficiency and work incentives, a UBI wins hands down over the current welfare system, and beats even the negative income tax famously championed by Milton Friedman, another classical liberal,.

Lifestyle libertarians

The libertarian sympathies of still others arise from the conviction that all people should be able to live their lives according to their own values, so long as they dont interfere with the right of others to do likewise. These lifestyle libertarians are drawn to a UBI because of its contrast with the nanny state mentality that characterizes current policies. Why should social programs treat married couples differently from people living in unconventional communal arrangements? Why should welfare recipients have to undergo intrusive drug testing? Why should food stamps let you buy hamburger and feed it to your dog, but not buy dog food?

Writing for Reason.com, Matthew Feeney urges libertarians to stop arguing in principle against the redistribution of wealth. Instead, he says, scrap the welfare state and give people free money. Feeney sees a UBI as an alternative that promotes personal responsibility, reduces the humiliations associated with the current system, and reduces administrative waste in government.

So there you are. A UBI is a policy for pragmatic critics of well-intentioned but ineffective government, for classical liberals, and for advocates of personal freedom. No wonder so many libertarians take the idea seriously.

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Why Should a Libertarian Take Universal Basic Income Seriously? - Niskanen Center (press release) (blog)

What I Saw at the Anti-Milo, UC Berkeley Riots! – Being Libertarian

Ticket screening was supposed to begin at 7:00 pm, so at around 6:15 pm I started walking up Telegraph Avenue towards the event at the Pauley Ballroom on the UC Berkeley campus. On my way there, I was already seeing ubiquitous anti-Milo Yiannopoulos signs calling this gay, Jewish, immigrant (who predominantly dates black men) a Nazi, a fascist, and many other unoriginal epithets sufficient to excite the decently large low information crowd around here.

I continued on through Sather Road coming closer to the Ballroom venue. I briefly walked into the supposed ticketing area, by the Amazon store, to get a better idea what was happening, but rioters were already throwing rocks, paintballs, and burning objects in that direction. Some of the store windows had been smashed in or blown out completely, barricades were torn down, and the attendees were totally exposed to the rioters standing a little further North (behind some weak metal barricades that were going not to last much longer). To me it was not clear where we were supposed to stand or have our tickets screened, it was all very chaotic, and things began to get dangerous for event attendees.

A big fire had erupted near where I stood because rioters had thrown a Molotov cocktail at a container that seemed to be leaking gasoline. At some point I heard a loud explosion, maybe even two. Firecrackers were continually being thrown in the general vicinity and a lamp pole had been torn down to the sound of cheers. The Cops were mostly inside the buildings staring outside, but they were not intervening at all as far as I could see. Id say there were about 30-40 cops, vs hundreds if not thousands of rioters and supporters.

I tried to connect with a fellow Being Libertarian writer in attendance, but it was difficult to find one another and his phone was dying.

Virtually everyone I saw, across the entire area all the way back to Bancroft & Telegraph, was excited, happy, giggling, taking photos, and basically having quite a blast. Behind the front line of rioters there were drummers, and a DJ, there was a real dance party going on. After theyd officially succeeded in shutting down the event, naturally followed by massive cheers of joy across what seemed like the entire campus, they broke through the barricades completely and moved towards Telegraph & Bancroft.

The rioters, who largely consisted of masked individuals brandishing Antifa flagpoles, lead the march; they were accompanied by continuous drum beats, hip hop music, and people dancing behind them, I could hear a rap song with the profound hook line Fuck Donald Trump.

Having attended alone, Id now successfully connected with another person on the events Facebook group and we met up on Bancroft and Sather Lane (note: its Lane now, not Road). Thats when the atmosphere turned from dark to terrifying!

Suddenly serious scuffles started in that area, Antifa rioters began to chase down, or sucker punch, Trump supporters and Miloattendees. I heard one Antifa protester, a woman, proudly proclaiming Hey, we found a bunch of Nazis over there! I saw a small group help a woman who was wearing a Make Bitcoin Great Again hat, who had been sucker punch pepper sprayed during a TV interview by a masked individual.

I saw one guy, surrounded by Antifa rioters, getting bludgeoned really bad as more backup, armed with flagpoles that were gratuitously utilized, came flooding in from behind. I suspect thats the body I later saw in this footage, where you can see him motionless on the road, surrounded and beaten with a flapole some more for good measure. I wonder if hes alive.

I saw two Trump supporters, one wearing a MAGA hat, chased down Bancroft Way towards Dana Street by another Antifa mob who were shouting things like Beat his ass!, and Get out Nazi scum!.

Here you can see the official protest organizer, Berkeley school district teacher Yvette Felarca, (who recently returned to her job after having been placed on leave pending an investigation into concerns that have been raised) explain how doing whatever is necessary to shut down Milos event is their right to self defense, thus clearly condoning the violence, arson, and destruction; how else would they have shut down the event? Its good to know that this unstable, and insecure cliche of a mental patient, is instructing children with your tax dollars, isnt it?

At this point I, and the friend Id made here, somehow got pepper sprayed or tear gassed, were still unsure where it came from. There was no police presence at all around here. With impaired vision, we fled in a direction that seemed to be the safest way to escape the violence.We managed to connect with a few more friendly event attendees down the street and exchanged experiences and information before we got out of the general area. It was a crazy night!

Heres an official legal definition of terrorism from Merriam Webster:

terrorism the unlawful use or threat of violence especially against the state or the public as a politically motivated means of attack or coercion.

In my opinion, this was not a protest, this was not even just a riot, this was well planned and coordinated domestic terrorism! The same kind of terrorism that we can [currently] observe all over the Western world, with matching signage, symbols, names, weapons, flags, strategies, chants, intimidation techniques, violent professional agitators, and so on.

So why not deal with it accordingly? How much longer will this behavior be tolerated?

If youre interested in more discussion on the topic, here is my call in to Freedomain Radio, together with my friend:

And here is a recorded conversation with another friend regarding the event, including some footage that he mixed in:

This post was written by Nima Mahdjour.

The views expressed here belong to the author and do not necessarily reflect our views and opinions.

Nima is an entrepreneur and Bitcoin advocate who writes about economics and freedom. He was born and raised in Berlin and received his Master's degree in the US in 2004. He co-founded an auction software company in San Francisco and successfully sold it in 2015. (Twitter: @economicsjunkie)

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What I Saw at the Anti-Milo, UC Berkeley Riots! - Being Libertarian

3 Questions for Bernie Supporters – Being Libertarian

Picture credit: The Huffington Post

Recently graduating from a left-leaning university, in a left-leaning city, with a majority left-leaning friends, all of whom are overly-equipped with cuddle bears and safe spaces, every day Ive had to suffer through hearing about the glorious socialist utopia that would come about with a Bernie Sanders presidency.

Having actually studied political science, focusing heavily on various countries policies and economics, I have to fight a constant urge where I dont lower myself to the lefts standards and go on a peaceful protest rampage. Fortunately, it has never come to that. Being well-equipped with a basic knowledge of economics and morality, one can ask three simple questions to stun any Bernie bro.

This is probably one of the best arguments against Sanders specific idea of socialism, as his views are radical even for a modern socialist.

While socialism never works in the long run, as we have seen with Venezuelas collapse and Sweden and Denmarks reduction in benefits and fragile economic systems, there are measures that can prolong its life.

Sweden and Denmark, both the golden standard for socialists, have some the lowest corporate tax rates in the world. In Sweden and Denmark, the corporate tax rate is 22 percent; whereas in the United States, we have a whopping tax rate of 38.9 percent; the second highest in the world. For socialism to be sustainable, even if it is only in the short run, Sweden and Denmark understood the necessity for investment. They needed incentives for companies to move to their country and employ their population.

As mentioned before, this still isnt enough to save them from disaster that occurs from any type of economic change, which usually leads to heightened unemployment, budget imbalance and increased deficit, and the inevitable removal or reduction in welfare benefits. However, Sweden and Denmarks policy on low corporate tax rates is something Bernie never addresses. Hedoesnt understand this and seeks only to ridicule corporations and the wealthy; the very people that provide the economic means to make socialism as sustainable as it will ever be. Could you imagine a millennial wrapping his head around the idea of lowering tax rates for those evil corporations? Me neither.

This is, arguably, the biggest flaw in Sanders socialist dream.

While this should be common knowledge for a Bernie supporter, youll find many dont actually know the answer or have looked at the in-depth causal effect of what is proposed.

Quoting from Bernie Sanders official site, he states: There is something profoundly wrong when the top one-tenth of one percent owns almost as much wealth as the bottom 90 percent. While this figure is mostly accurate, there are debates about its validity. Politifact references fellow libertarian Daniel Mitchell when he argues that tax laws in the late 20th century required high income taxpayers to report capital income, while middle income citizens didnt have to. Despite this fact, Mitchell goes on to say that the rich arent rich because the poor are poor; the rich are rich, because they are innovative and provide services which others want.

Back to the question at hand. While Bernie mostly relies on demonizing the wealthy, there are instances where he provides a plan to redistribute the wealth.

They consist of raising taxes on the rich, raising the minimum wage, providing government-funded youth programs, and other expensive programs, all to be billable to higher income individuals. At this time, the top 10 percent already pay 68 percent of all federal income taxes and 53 percent of all federal taxes in general.

What happens when that tax rate widens and the wealthy pay more in taxes and middle class pays less? If you believe those in the top 10 percent are millionaires, youre very wrong. The income for the top 1 to 10 percent is between $380,354 to $113,799. In other words, essentially anyone that owns and operates a successful business. The people that took a risk with their own money, bet on themselves, and came out positive; the people that are providing jobs to the middle class; the people that have to put payroll on their own credit card and often use their own funds to invest in their company; those are the people that Bernie Sanders wants to tax even more, and he hides that fact by having the public perceive the top 10 percent as fat oil men sitting on a mountain of cash.

By redistributing wealth, you are essentially taking money from those that provide the jobs for everyone else, invest and take rise, and essentially keep the economy going. Not only is it morally wrong, but economically idiotic.

The American Dream is based on an idea that anyone can succeed in this country if they have the desire to work hard enough. It is one of the major reasons that America has had the most successful economy since World War II.

The government, specifically under Reagan and Clinton, facilitated an environment where people could achieve anything, because the government would interfere as little as possible. It is why the Reagan and Clinton years (despite the Democrats stance on the economy today, Clintonomics was very much in favor of being enterprise-friendly and making the government smaller) were some of the best economic years in American history.

Bernie Sanders plan is to go against this logical concept, and label the successful and wealthy as the enemy and everyone else as the victim. So, if a successful economy is determined by innovation and a strong working class as Reagan and Clinton proved how do you incentivize people to take risk on themselves and open businesses or try to get a promotion and make more money, when the more money you make, the more is taken away?

* Braden Paynter is your average Joe Schmoe, who loves his country and all the freedom it entails. He has received an education in political science and international politics, being one of the few in his class to emerge without shouting leftist propaganda at the top of his lungs.

The main BeingLibertarian.com account, used for editorials and guest author submissions. The views expressed here belong to the author and do not necessarily reflect our views and opinions. Contact the Editor at editor@beinglibertarian.email

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3 Questions for Bernie Supporters - Being Libertarian

IdPol: The Bastard Grandchild of Marx’s Ressentiment – Being Libertarian

Im not at all a fan of the term Cultural Marxism, which gives off a massive whiff of anti-Semitic conspiracy-mongering. I never use the term.

However, the fact that the far right speak about alleged analogies between Marxism and more current ideological trends in a very mystificatory and misleading manner doesnt mean that the more extreme and authoritarian ideological tendencies and practices in the Occident of today dont have any analogy whatsoever with Marxism.

This selective reading of Marxs and Engels The Communist Manifesto will pinpoint and elaborate upon some of these problems.

First of all, after the gripping opening prose-poem A spectre is haunting Europe, Chapter I begins with the following words:

The history of all hitherto existing society is the history of class struggles.

It seems that here, Marx and Engels are at least somewhat realistic in their views; human history is not a cotton-candy fairy tale of unmitigated bliss. There is no anachronistic and irredeemably pious petit-bourgeois cant about tolerance (God forbid there should be any classical toleration instead!) or celebrating diversity (humanity forbid anyone should provisionally suspend judgment on the relative value of any particular identity or worldview!). It is tempting to suggest that if Marx and Engels were here today, the rootless, sugar-sweet, sickly wheedling of idle humanitarian sentimental would meet with their disapproval also.

However, there is a curious iron here. The word hitherto is a bit of a giveaway. As is well known, Marx and Engels postulated an End of History no less whimsical and Quixotical than that of Fukuyama. And as is well enough known, Marxs late work from his deeply embittered old age, Critique of the Gotha Program (and when was he ever not embittered?) clearly and unequivocally states that the channel to paradise is paved with torrents of blood and torment.

Is this not also the case of authoritarian, post-liberal IdPol? On the one hand, social justice warriors and regressive leftists see all life in radically agonistic and zero-sum terms. White folks and POC, Zionist and anti-Zionist, Jew and Palestinian, capitalist and the-right-kind-of-worker (the ideologically correct one!)

Or in a word: Oppressor and oppressed

Such shall it ever be, world without end.

And yet, at the same time, such ideologues are curiously solutions-orientated, in the sense that the Party of Justice, and they alone, have the correct panaceas to reconcile such conflicts; and to bring about, either a material world that is purged from all suffering, or at least a spiritual one: to wit, the realm of symbolic violence, i.e. of the violence of language and discourse, is to be purged and cleansed entirely of the slightest traces of coercion and exclusion.

For sadly, the very idea that such violence is intrinsic to human communication or (Foucault forbid!) The Human Condition, is at most tokenistically acknowledged; it is but very rarely treated as something of practical significance.

Thus, while Marx and Engels emphasized, or even over-emphasized the role of conflict and violence in history, thereby avoiding the naivety of a certainly unreconstructed or nave humanitarian liberalism; so also do IdPol ideologues.

And while Marx and Engels believed that despite the hitherto-history with which they had to content, there was still substantial grounds for hope that they would one day manage to tie up every loose knot, on account of their superior knowledge, their mystical insight, and their resplendent virtue; so also do IdPol ideologues present themselves not only as liberators, but as bearers of a liberation not merely radical, but well-nigh absolute in character.

For what could be more infinite and unbounded in its bliss and bounty for any over-fastidious anarchist-emperor, than replacing the Ancien Regime of individual-truck-and-trade-offs between different forms of symbolic violence; with a Brave New Spiritual Economy of a language and discourse purged, renewed, resurrected in snow-white robes of gold, singing hymns of joy and glory evermore to the Saviors of the Weak and Weary?

And yet, more. In chapter 3, we are graced with the following charming and ennobling words:

The French Socialist and Communist literature was thus completely emasculated. And, since it ceased in the hand of the German to express the struggle of one class with another, he felt conscious of having overcome French onesidedness and of representing, not true requirements, but requirements of Truth: not the interests of the proletariat, but the interests of Human Nature, of Man in general, who belongs to no class, has no reality, who exists only in the misty realm of philosophical fantasy.

Similarly, IdPol apologists are ever posturing and pontificating regarding the misleadingly ideological character of Humanity. Now, certainly, their anti-humanitarianism is laudable, in the sense of their faltering, twilight-stumbling rejection of nonsensical imperative to sacrifice the interests individuals to an imaginary Good of Humanity which is merely a cover for the abusive behavior of the ruthless perpetrators of humanitarian aggressions in the Balkans, Afghanistan, Syria, and elsewhere.

But to be one-sidedly anti-humanist, in the sense of rejecting the perfectly laudable notion that the business of human beings is the business of human beings? Now that is surely not the same thing!

And yet, doesnt Marxs own self-anointing ex cathedra arrogance sound familiar? Not unlike the petit-bourgeois intellectual bureaucrat par excellence himself, social justice warriors boast of having somehow overcome the partisan biases of unreconstructed humanists, vulgar liberals and nave and primitive (!) modernists

So, instead of the dry, dusty, hand-me-down manna of the classless subject, let them gorge upon the heavenly nectar of the subjectless subject instead!

Ultimately, as Karl Marx himself once said:

History repeats itself. The first time as tragedy, the second as farce.

Regressive Leftist IdPol, just like Marxism, offers a magic bullet for the wounds of liberalism.

But the fact its self-appointed apothecaries make modest claims about their toxic brews, in order to make them a little sweeter to the cynic and less septic to the skeptic, does not make their infallible fallibility, their dogmatic scepticism, or their rigid dynamism, any the less buffoonish.

* Jonathan Fergusons freelance journalism includes, but is not limited to, his two guest blogs: at Times of Israel, he presumtuously aspires to be an honest broker on the Israel/Palestine issue, while at Sputnik, he has a nice salty mug of McCarthyite tears, with a few Far Center Fauxlib vanilla sprinkles for extra sweetness. He has zero love for Humanity and has no regard whatsoever for the National Interest. And like you, he has just about enough good sense to know that all this callous indifference and nihilism of his as far removed from actual selfishness as you could possibly ever get.

The main BeingLibertarian.com account, used for editorials and guest author submissions. The views expressed here belong to the author and do not necessarily reflect our views and opinions. Contact the Editor at editor@beinglibertarian.email

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Libertarian Party Gets Victory in Suit Aimed at the Partisanship of Commission on Presidential Debates – Reason (blog)

The Libertarian Party, and fellow plaintiffs, won a victory in federal court this week in the case of Level the Playing Field v. FEC. (The full background of the case can be read from reporting here when it was first assigned its day in court and when the oral arguments occurred.)

Gary Johnson Facebook

To quote from my previous reporting summing up what was at issue in the lawsuit, which while technically against the Federal Election Commission (FEC) is ultimately targeting the Commission on Presidential Debates (CPD) for locking out third parties while pretending to be nonpartisan, the L.P. and its co-plaintiffs claim that:

the CPD has always been a deliberate duopoly for the two major parties and has "been violating FECA and FEC regulations limiting debate-sponsoring organizations' ability to use corporate funds to finance their activities" since its efforts are not truly "nonpartisan."

The suit accuses the FEC of "refus[ing] to enforce the law and ignored virtually all of this evidence in conclusorily dismissing the complaints even though there is plainly reason to believe that the CPD is violating FECA...."...

"The Court should...direct the FEC to do its job, which is to enforce the law and put an end to the CPD's biased, anti-democratic, and fundamentally corrupt and exclusionary polling rule."

Judge Tayna Chutkan in U.S. District Court for D.C. agreed with the L.P. and others that the FEC was derelict in its duties when it blithely refused to act on the those complaints about the CPD.

Plaintiffs allege that the Federal Election Commission ("FEC") has violated the Administrative Procedure Act ("APA").... in dismissing two administrative complaints regarding the CPD and in denying a petition to engage in rulemaking to change the FEC's regulations regarding debate staging organizations.

Judge Chutkan explains how CPD's operations should be affected by the FEC and its enforcement of election finance law:

The debate staging regulation...acts as an exemption to the general ban on corporate contributions to or expenditures on behalf of political campaigns or candidates. To prevent debate staging organizations such as the CPD from operating as conduits for corporate contributions made to benefit only one or two candidates from the Democratic and Republican partiesvia the much-watched prime-time debatesthe regulations require these organizations to (1) be nonpartisan, (2) not endorse, support, or oppose candidates or campaigns, and (3) use pre-established, objective criteria.

If a debate staging organization fails to comply with the regulations, such as failing to use objective criteria in determining which candidates participate in its debates, then the value of the debate is actually a contribution or expenditure made to the participating political campaigns in violation of the Act.

The Act provides that any person who believes a violation of the Act has occurred may file an administrative complaint with the FEC...

The L.P. and its co-plaintiffs filed such a complaint in September 2014, as well as "a Petition for Rulemaking with the FEC [that] asked the FEC...to specifically bar debate staging organizations from using a polling threshold as the sole criterion for accessing general election presidential and vice-presidential debates."

They were not satisfied with the FEC's reaction, leading to the current lawsuit "challenging the dismissal of their administrative complaint...and the agency's decision not to engage in rulemaking" about the debate threshold.

Judge Chutkan agrees that the FEC did a shoddy and careless job in actually considering and reacting to the arguments and evidence the L.P. and others presented about the potential partisanship of CPD, and thus:

the court cannot defer to the FEC's analysis and further concludes that the FEC acted arbitrarily and capriciously and contrary to law when it determined that the CPD did not endorse, support, or oppose political parties in the 2012 election....On remand, the FEC is ORDERED to articulate its analysis in determining whether the CPD endorsed, supported, or opposed political parties or candidates....

....the FEC must demonstrate how it considered the evidence, particularly, but not necessarily limited to, the newly-submitted evidence of partisanship and political donations and the expert analyses regarding fundraising and polling.

As for the argument that the CPD's 15 percent polling requirement for third party access is not properly objective and is in fact clearly designed to privilege major parties, Judge Chutkan:

GRANTS Plaintiffs' motion....as to whether the FEC's analysis of the criterion's objectivity was arbitrary and capricious and contrary to law. While the court cannot and does not mandate that the FEC reach a different conclusion on remand, the court notes that the weight of Plaintiffs' evidence is substantial, and the FEC must demonstrate that it actually considered the full scope of this evidence, including the CPD chairmen's and directors' partisan political activity and the expert reports, as well as explain how and why it rejected this evidence in deciding that the CPD's polling requirement is an objective criterion

Judge Chutkan spells out that the L.P. and its co-plaintiffs:

clearly argued, and attempts to establish with significant evidence, that in presidential elections CPD's polling threshold is being used subjectively to exclude independent and third-party candidates, which has the effect of allowing corporations to channel money to the CPD's expenditures to the C campaigns they would be prohibited from giving the campaigns directly.

It further argued and presented evidence that polling thresholds are particularly unreliable and susceptible to this type of subjective use at the presidential level, undermining the FEC's stated goal of using "objective criteria to avoid the real or apparent potential for a quid pro quo, and to ensure the integrity and fairness of the process." In its Notice, the FEC brushed these arguments aside....

Judge Chutkan is thus demanding the FEC do a better job actually grappling with those arguments. This does not mean that the CPD is on the ropes or will somehow instantly be required to either give up its firewall against third parties or stop taking in the corporate bucks.

But it does mean the FEC is going to have to come up with convincing reasons why the CPD isn't bipartisan rather than nonpartisan and why the CPD's debate inclusion criteria are fair and objective and not partisan. It will be interesting to see what they come up with.

Via the always indispensable Ballot Access News.

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Libertarian Party Gets Victory in Suit Aimed at the Partisanship of Commission on Presidential Debates - Reason (blog)

Chinese ships sail near disputed Japanese islands – CNN

Japan controls the chain and calls them the Senkaku Islands, while China calls them the Diaoyu Islands.

According to Japanese broadcaster NHK, protests were lodged with the Chinese Embassy in Tokyo and in Beijing through the Japanese Embassy.

China's State Oceanic Administration, which oversees the country's Coast Guard, put out a statement late Monday saying the three ships "cruised within China's Diaoyu Islands territorial sea."

China's Defense Ministry, which is separate from the Oceanic Administration, posted a statement on its website confirming the Coast Guard ship movement.

Japan's Coast Guard said the Chinese vessels spent two hours in Japanese territorial waters.

It was the fourth time Chinese ships have entered Japan's waters this year, the Japanese Coast Guard said. There were 36 such incidents in 2016, it said.

"I made clear that our long-standing policy on the Senkaku Islands stands -- the US will continue to recognize Japanese administration of the islands and as such Article 5 of the US-Japan Security Treaty applies," Mattis said in a press conference with Japanese Defense Minister Tomomi Inada.

China responded quickly on Saturday to the US stance on the islands, saying it brings instability to the region.

"Diaoyu and its affiliated islands have been Chinese territory since ancient times. These are historical facts that cannot be changed. The so-called US-Japan security treaty was a product of the Cold War, and it should not harm China's territorial sovereignty and legitimate rights," Chinese Foreign Ministry spokesman Lu Kang said in a statement.

"We urge the US side to adopt a responsible attitude and stop making wrong remarks on the issue of the sovereignty of Diaoyu Islands," Lu said.

The US commitment to the Senkaus, which Mattis also reaffirmed in a Friday night meeting with Japanese Prime Minister Shinzo Abe, is not new. In 2014, the Obama administration also said the remote chain fell under the treaty.

In late 2013, Chinadeclared an air defense identification zone (ADIZ) over much of the East China Sea, including the Senkakus, despite objections from Tokyo and Washington.

Japan also has an ADIZ over the islands. Although the Senkakus are uninhabited, their ownership would allow for exclusive oil, mineral and fishing rights in the surrounding waters.

While the Senkakus remain a source of friction in the US-China relationship, Mattis' visit seemed to have soothed relations a bit in another area, the South China Sea.

Although the US defense chief said "China has shredded the trust of nations in the region" by fortifying disputed South China Sea islands, Mattis also said no increased US military maneuvers there were needed.

Lu, the Chinese Foreign Ministry spokesman, on Monday welcomed that stance.

"As for Mattis' comment that there is no need for large-scale military operations in the area and the issue should be resolved through diplomacy, these remarks deserve our affirmation," Lu said.

CNN's Yuli Yang, Steven Jiang and Yoko Wakatsuki contributed to this report.

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Chinese ships sail near disputed Japanese islands - CNN

Russian millionaire details plans for new Romanov empire on Pacific islands – The Guardian

Russian businessman Anton Bakov (left) and Kiribatian MP Emil Schutz in Kiribati. Photograph: Maria Bakov

A Russian millionaire is in advanced talks with the Kiribati government to lease three uninhabited islands and establish an alternative Russia and revive the monarchy.

Russian Anton Bakov and his wife Maria are planning to re-establish the Romanov Empire on three remote islands in the south Pacific nation of Kiribati, and invest hundreds of millions of dollars into the impoverished islands economy.

The Russian monarchy was overthrown by the Bolshevik revolution in 1917 and Bakov, a businessman and former Russian MP, has devoted himself to reviving it which over the years has included exploring options for a base in Montenegro and the Cook Islands.

Bakov has now proposed leasing the uninhabited islands of Malden, Starbuck and Millennium to use as a base for his alternative Russia, as well as building infrastructure for tourists and businesses.

According to Bakov and the Kiribati government, the three islands are completely uninhabited and undeveloped and Bakovs offer is the largest investment ever considered by the island nation.

We were drawn to Kiribati due to the wonderful climate, big and spacious uninhabited islands and small population, which would obviously benefit from our financial assistance said Bakov by email.

Bakovs son Mikhail first approached the Kiribati government in late 2015 with his fathers investment plan.

After meeting with the Bakovs earlier this year the President of Kiribati, Taneti Mamau, set out with a number of government ministers to inspect the three islands in person.

The round-trip was expected to take up to a month and a decision on whether to proceed with the deal would be made on the presidents return near the end of February.

We are planning to construct air and sea ports, solar power stations, freshwater plants, hospitals, schools and settlements for the employees, said Bakov.

The main economic objects of the islands will be eco-friendly hotels and fish processing plants. We would also develop tropical agriculture and Russian Imperial University.

The development of the islands would take between ten to fifteen years, estimated Bakov, and it was projected up to 1000 I-Kiribati as residents of the islands are known largely recruited from Christmas Island some 670km away, would eventually be employed.

The first stage of the project would be an immediate financial injection of US$120m to the Kiribati government, said Bakov, followed by US$230m for the first stage of infrastructure construction on Malden Island, as well as additional taxes and customs for the Kiribati government.

Although the islands would act as a base for the Romanov Empire, Bakov did not anticipate many Russians migrating permanently to Kiribati, as the climate was too harsh and the distance would be too great.

The equatorial climate doesnt suit so well the Russian people ... we consider that the immigration to Australia and NZ will still be much more desirable for them, he said.

So we would assume the quantity of the Russian people living permanently on the islands will be one to two percent. However financial investments from the Russians will be much more considerable.

Emil Schutz, an I-Kiribati MP who has been working closely with the Bakovs on the project, said his country had tried for decades to spark international investment in Kiribati, but rising sea-levels and the projected impact of climate change were a strong deterrent.

Although large swaths of Kiribati are at imminent threat of rising sea levels, Malden Island is higher than the mainland of Kiribati and the effects of climate change would take longer to be felt, Schutz said.

Schutz said the Bakovs monetary investment in Kiribati was the governments primary concern, and the establishment of a base for the Romanov Empire was a secondary consideration, but Schutz felt the impact of reviving the Russian monarchy had been overstated and that was not the Bakovs primary motivation for investing in Kiribati.

These islands are very remote and far away from the main islands, and if the government wanted to do something to develop them it would cost millions of dollars, which is not a priority at the moment, said Schutz, who said the proposal was currently being assessed by the Foreign Investment Commission.

The country has been looking for investors since independence, and no one has been interested in investing any money. It is a good thing that someone is looking at doing something on these islands that arent being used by the government or people living on them. I would be very interested to see something happen on these islands.

According to Schutz, the three islands in question are arid and lacking in natural resources, having been extensively mined of their rich phosphate stores by an Australian mining company many decades ago.

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Russian millionaire details plans for new Romanov empire on Pacific islands - The Guardian

Rainforest Trees Are Like Islands – The Atlantic

In the 1970s, biologists realized something interesting about islands: There was a correlation between their size and the number of species they harbored, apparently a kind of evolutionary natural law. Soon, the idea was extended to other kinds of geographythe number of mammal species on mountaintops, similar to islands in their isolation, can also be predicted by their area. The relationship between species number and area has become one of the abiding fascinations of modern ecology. Now, drawing on six years of fieldwork in rainforest trees, perching in their crowns and watching the comings and goings of ants, researchers can report that the leafy giants also follow this rule.

There are more than 400 ant species roaming the rain forest, with about 120 of them living or spending their time in trees, says Steve Yanoviak, an ecologist at University of Louisville and the Smithsonian Tropical Research Institute. Yanoviak has spent the last 25 years ascending to the treetops with rock-climbing equipment to study ants as they roam around in those floating worlds, connected only with woody vines called lianas. As I was climbing trees, looking around in the canopy, he says, recalling the beginning of this project, it became pretty clear to me that ants actually were using lianas to get from place to place. Did trees connected by lianaspart of a network of high-wire highwayshave more species diversity than those that stood alone? And did those that stood alone, unconnected, have patterns in species numbers like islands and mountains?

He and his graduate student Benjamin Adams have been working to answer those questions in the Panamanian forest of the Barro Colorado National Monument. They have recently published a new study, for which the researchers and assistants climbed up to the crowns of more than 200 trees and put out a dollop of tuna or meat mixed with honey. That's basically a dream food for an ant, Yanoviak says, and it draws them in over the course of the one-hour observation period. The researchers kept track of which ants showed up to feed or just wander through.

Over the six years of the study, they found that larger standalone trees do tend to have larger numbers of ant species than smaller ones, much like islands or mountain tops. Thats interesting, Yanoviak says, because the trees are not all that far from each other, even for ants. We were really impressed to see that mathematically, the size of the tree determines how many ant species live in it, he says, as long as it doesnt have lianas.

Because when the trees are connected by lianas, that pattern disappears. Trees with vines, regardless of size, have more ant species than unconnected trees, on average an increase of 25 percent. It doesnt matter if you have one or 100 lianas, you will have more species, Yanoviak says.

Essentially, once the trees are connected with vines, they dont function as individual trees anymore, from the perspective of ant biodiversity. That suggests that these vines are important thoroughfares and promoters of biodiversity in the forest, turning it from an archipelago of tree islands to something larger and more connected.

The researchers expect to release another chapter in the tale of the ants and vines in the near future. In these same research plots, the studys third author, Stefan Schnitzer, has been running a parallel experiment concerning the effect of lianas on the trees themselves. Part of the experiment involves removing the lianas from half the plots to see how the trees respond. Adams and Yanoviak have been watching to see what the ants do. Even with their super-highways gone, so far, the ants seem to be surprisingly resilient, and loyal to their now-isolated home trees.

You could tell they didnt like it, he says. They shut down their activities and stopped foraging. But they didn't disappear or pack up and leave.

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Rainforest Trees Are Like Islands - The Atlantic

China Assails US Pledge to Defend Disputed Islands Controlled by Japan – New York Times


New York Times
China Assails US Pledge to Defend Disputed Islands Controlled by Japan
New York Times
BEIJING China reacted with strong displeasure on Saturday to a promise by Defense Secretary Jim Mattis that the United States would defend two uninhabited islands in the East China Sea that Japan controls but China also claims as its own. Mr. Mattis ...
Islands on the frontline of a new global flashpoint: China v JapanThe Guardian
Mattis: US will defend Japanese islands claimed by ChinaCNN
US would defend Japan's disputed islands despite Chinese warningUPI.com
New York Post -ABC News
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China Assails US Pledge to Defend Disputed Islands Controlled by Japan - New York Times

Early Islands – Paste Magazine

When you think about man-made islands, your thoughts may immediately go to Palm Jumeirah in Dubai or any number of other artificial islands around the world. But what most dont know is that people have been building islands in the British Isles for thousands of years.

These early islands, known as crannogs, look much different than a typical island and consisted of wooden stakes or piles that were driven into lake beds and supported hut-like dwellings. Scientists have discovered hundreds of these structures throughout Scotland and Ireland, many dating back as far as five thousand years ago.

Leading the way in uncovering the crannogs is Nick Dixon, director and founder of the Scottish Trust for Underwater Archaeology. He and Barrie Andrian lead the excavation of Oakbank crannog on Loch Tay in Kenmore, Scotland.

Oakbank, where digging began in 1980, was the first underwater excavation of its kind in Scotland and to this day is still only halfway completed. The crannog is incredibly difficult to excavate because the site forms a 10-ft mound of material that measures 35,000 cubic feet, all of which lies underwater and must be studied by divers.

The 13-mile-long Loch Tay is home to at least 18 catalogued crannogs, most of which have not been fully excavated. Many of Scotlands lochs hold the remnants of crannogs from the 5th or 2nd centuries BC and offer archaeologists incredible information about the people who created them.

Theres a wealth of information down there, and the potential to rewrite prehistory and history, actually is enormous, said Andrian.

Dixon and Andrian, along with a team of researchers and scientists, constructed a replica of a crannog at the Scottish Crannog Centre that utilizes the same building materials and techniques that were most likely used in the original construction thousands of years ago.

By studying these structures, scientists believe that the crannogs were built as a defensive settlement and served as home to people off and on for centuries. Environmental stress on the land surrounding the lochs may have driven the people closer to the water and into more secure communities.

Because of limited funding and time, research on the crannogs is not as extensive as Dixon and Andrian would like, though they are hopeful that continued excavations of the Oakbank site will continue to give a better picture of what these original island-builders were like and how they formed their architectural wonders.

Top photo by Stuart Anthony CC BY-NC-ND 2.0

Lauren Leising is a freelance writer based in Athens, Georgia.

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Early Islands - Paste Magazine

Former Steinbrenner home on Davis Islands sells for nearly $6.3 … – Tampabay.com

TAMPA Tampa's Bay's luxury market is kicking off another strong year with the $6.275 million sale of an 8,000-square-foot bayfront home on Davis Islands.

The seven-bedroom, seven-bath home sold in late January in an off-market transaction. The deed had not been recorded as of Friday, but the seller was a pair of trusts in the name of Christina S. Lavery, records show.

Lavery formerly was married to New York Yankees chairman Hal Steinbrenner, who with his brother Hank inherited the team from their late father, George Steinbrenner.

Tampa Bay notched eight sales above $6 million last year compared to none in 2015. Of the top 25 priciest homes sold last year, four were in Davis Islands, the most of any bay area community.

Previous coverage: Here are Tampa Bay's 25 priciest homes of 2016

"There is a very limited supply of open bay property in Tampa,'' said Stephen Gay, the Smith & Associates listing agent. "Davis Island is exceptionally attractive because it is very convenient to downtown Tampa and all South Tampa has to offer.''

Contact Susan Taylor Martin at smartin@tampabay.com or (727) 893-8642. Follow @susanskate

Former Steinbrenner home on Davis Islands sells for nearly $6.3 million 02/06/17 [Last modified: Monday, February 6, 2017 3:44pm] Photo reprints | Article reprints

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Former Steinbrenner home on Davis Islands sells for nearly $6.3 ... - Tampabay.com

Future Islands played 7 new songs at House of Vans Chicago’s … – Brooklyn Vegan (blog)

With the original Brooklyn location open for five years (and one in London too), House of Vans has opened a second U.S. skate park/music venue, this one in Chicago. Future Islands christened the spot on Friday night (2/3), as part of a two-day Grand Opening celebration that also featured an open-house community even on Saturday (2/4). This was also the first show for Future Islands since announcing new album The Far Field, and they played seven of its 12 songs, including first single Ran, as well asfavorites like Balance, Spirit and hit Seasons (Waiting on You) peppered in. You can watch live video of them playing The Far FieldsRan and Aladdin and other songs, along with the House of Vans Chicago setlist, below.

The night also featured reunited 90s hip hop stars Digable Planets and rising Chicago rapper Noname. Pictures from their sets, and more of Future Islands, are in the gallery above.

Aladdin

Ran

SETILST: Future Islands @ House of Vans Chicago 2/3/2017 Aladdin * Ran * Long Flight Balance Cave * Candles * Day Glow Fire * Seasons (Waiting on You) North Star * Time on Her Side * Walking Through That Door Tin Man Spirit * = new song

photos by James Richards IV

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Future Islands played 7 new songs at House of Vans Chicago's ... - Brooklyn Vegan (blog)

Saanich Peninsula, Gulf Islands schools closed as snow warning issued – Times Colonist

Update: Snowfall forced B.C. Transit to cancel at least 11 routes; at least 16 routes had to make detours to avoid treacherous streets, especially areas with hills.

Central Saanich police pulled over a Zamboni ice-rink-cleaning machine that was being used to clear roads by the Patricia Bay Highway.

- - -

Heavy snow and near blizzard conditions on southern Vancouver Island wreaked havoc on all forms of transportation Monday.

Aircraft, cars, buses and transport trucks were all delayed or faced poor driving conditions as snow continued through the day, with heavy snow falling late in the afternoon as temperatures fell.

Environment Canada issued a snowfall warning for Greater Victoria, advising that it would be worse on the Malahat.

The B.C. Ministry of Transportation said that heavy snowfall caused whiteout conditions on the Malahat in the afternoon. Drivers reported around 3:30 p.m. that northbound traffic was stalled with some cars slipping backwards.

A car driving too fast for the wintry conditions skidded off the slick roads and plunged 20 feet down a ravine in Cobble Hill.

Shawnigan Lake RCMP, Cowichan Bay Volunteer firefighters and B.C. Ambulance responded to the 3800 block of Cobble Hill Road just before noon to find the car down an embankment, said Fire Chief Charles Brown.

First responders climbed down the embankment, open the drivers door and help a woman up to the roadway, Brown said. The driver was taken to hospital with minor injuries.

When youre sitting around the zero-degree mark, this is probably one of the worst times for traction, Brown said.

Another vehicle incident north of Goldstream Park around 4:30 p.m. caused delays for drivers on the Trans Canada.

Shawnigan Lake RCMP advised anyone travelling over the Malahat to slow down, by as much as 20 km/h depending on conditions and leave lots of room between cars.

Harbour Air was grounded Monday as snow ruled the skies. We lost the day today, said Harbour Air executive vice-president Randy Wright. About 100 flights are grounded coast-wide when they shut down completely.

Harbour Air had been shut down on Friday and Saturday but managed to get morning flights into the air on Sunday before shutting down again in the afternoon.

Aircraft at Victoria International Airport had better luck Monday, but not much.

James Bogusz, vice-president of airport operations, said more than a dozen flights were cancelled and at least 50 per cent of flights that managed to get away were delayed.

Theres lots of snow at YYJ and lots of delays and cancellations today. The snow is having a big impact on travel, he said. Believe it or not though, the runway conditions here are pretty good but a lot of the backlog at Vancouver and Seattle is causing lots of grief for passengers getting in and out.

Roads all over Greater Victoria were a mess Monday with police forces reporting several minor collisions.

Victoria police asked drivers to consider not driving Monday afternoon when the heavy snow started to stick to the ground. As temps cool it will get even more slick out there, they said on Twitter.

Earlier in the day in Oak Bay, a car lost control on slippery roads at the corner of Haultain and Epworth streets around 9:15 a.m. and struck a fire hydrant, which caused a geyser of water to spill onto the streets, flooding several basements.

A single vehicle lost control coming down the hill and struck a hydrant, knocking the hydrant off the water main, said Oak Bay Fire Assistant Chief Gord Marshall.

A substantial amount of water gushed from the line, flowing down the road and into the basements of four homes on Epworth, Marshall said.

Oak Bay public works employees were on scene quickly and isolated the hydrant, cutting off the flow of water to prevent further damage. Firefighters pumped out one basement and used water vacuums to remove water from the other three homes.

Victoria police responded to two crashes Monday morning as a result of the slick conditions.

One car lost control on Esquimalt Road but the driver was uninjured. Around 10:30 a.m., two cars collided in a rear-ender in the 2600-block of Douglas Street, resulting in minor injuries to one person.

Just before 4 p.m., West Shore RCMP responded to a vehicle that flipped in the ditch on Sooke Road near Humpback Road. Three people in the car were uninjured.

The City of Victoria reported it started brining roads and plowing on Sunday to keep roads clear.

City officials reminded residents that it is a homeowners responsibility to keep the sidewalk in front of their residence clear of snow. Failure to do so can mean a fine of up to $125.

But on Monday night, snow was falling so fast and so heavily, residents in many parts of the region couldn't keep up with the onslaught, finding their driveways quickly filling with snow shortly after they shovelled. On one Oak Bay street, residents were out by the dozen clearing their sidewalks, some for the second or third time in the day.

Ryan Coney, manager of Totem Towing, reported they had more than 110 calls mostly minor accidents and cars off the road before noon on Monday. Normally the company handles 175 to 200 calls per day.

In Nanaimo, snow clearing crews were out with all available snow equipment on the road, and the city ordered another 600 tonnes of road salt.

To prepare for the big dump of snow crews started brining roads last Thursday and have been plowing and salting priority routes continually since 6 a.m. Friday. Crews will be moving onto secondary routes and residential areas as weather conditions allow.

Crews are working in the residential areas now, they will continue to do so until the weather moves them back to the priority routes, said David Myles, Nanaimos manager of roads and traffic services. We are anticipating more heavy snowfall this afternoon and into the evening. Please use care and caution when driving on snow covered roads.

B.C. Transit warned passengers in Victoria that road conditions could cause some buses to run behind schedule. Seven routes in Greater Victoria were adjusted because of weather.

Bus passengers are advised to check bctransit.com before embarking.

Schools in School District 63 were closed Monday, mostly affecting students on the Saanich Peninsula. Gulf Islands schools were also closed, along with Pacific Christian in Saanich and Queen Margarets in Duncan.

Camosun College cancelled evening classes at both campuses.

Saying winter conditions made some roads too icy and unsafe for its trucks, the Capital Regional District cancelled blue box collection in Dean Park.

Affected reidents were advised to hold onto their recyclables until Feb. 11.

The Greater Victoria school district cancelled all evening rentals of its facilities.

Snowfall is expected to continue into Tuesday morning. Warmer weather is forecast beginning Thursday.

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Saanich Peninsula, Gulf Islands schools closed as snow warning issued - Times Colonist

Medical College of Wisconsin names new director for human genetics center – Milwaukee Business Journal

Medical College of Wisconsin names new director for human genetics center
Milwaukee Business Journal
At the Mayo college in Rochester, Minn., Urrutia is a professor in the departments of biochemistry and molecular biology, biophysics and medicine. He is director of epigenomics education and academic relationships in the epigenomics program of the Mayo ...

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Medical College of Wisconsin names new director for human genetics center - Milwaukee Business Journal

Why You Are Short (Or Tall): Human Genetics, Explained – Medical Daily

If you feel youre too short or too tall you can blame your genes. And it looks like theres plenty of blame to go around.

A study in Naturehas identified dozens of infrequently occurring genetic variants that are associated with human height to a moderate or large degree, some of them carrying an influence of up to 2 centimeters (more than of an inch). A number of the DNA elements are tied to genes already known to affect growth, such as those affecting bones and hormones, but others represent new processes involved in growth and height. That latter group could potentially lead scientists to new treatments for growth disorders.

Read: Technology To Change Genes Could End Tuberculosis

In the context of precision medicine, the results also bring hope to understand the genetic basis of complex diseases such as diabetes or schizophrenia, according to the Swiss Institute of Bioinformatics. The idea is that if we can understand the genetics of a simple human trait like height, we could then apply this knowledge to develop tools to predict complex human diseases, researcher Zoltn Kutalik said in the institutes statement.

According to SIB, the research relied on the international effort of more than 300 scientists and pulled DNA data from more than 700,000 people.

Your body might contain genes that can add up to 2 centimeters to your height. Pixabay, public domain

While previous research has fingered hundreds of genetic variants for playing a role in height, the Nature study notes that those variants are much more common, butplay only a marginal role in a persons measurement. The newly discovered variants have greater than 10 times the average effect of common variants.

While DNA plays the biggest role in how tall we are, our diet and our environment also influence how we measure up. For instance, Scientific Americannotes that protein is the most important nutrient for final height. Minerals such as calcium, vitamin A and vitamin D are also significant. Because of this, malnutrition in childhood is detrimental to height.

Source: Marouli E, Graff M, Medina-Gomez C, et al. Rare and low-frequency coding variants alter human adult height. Nature. 2017.

See also:

Genes Tell Us Whether Youll Drop Out of School

How a Blood Transfusion Changes Your DNA

How Evolution Will Change Our Bodies

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Why You Are Short (Or Tall): Human Genetics, Explained - Medical Daily

Genomes in flux: New study reveals hidden dynamics of bird and mammal DNA evolution – Phys.Org

February 6, 2017 Credit: NIH

Evolution is often thought of as a gradual remodeling of the genome, the genetic blueprints for building an organism. But in some instance it might be more appropriate to call it an overhaul. Over the past 100 million years, the human lineage has lost one-fifth of its DNA, while an even greater amount was added, report scientists at the University of Utah School of Medicine. Until now, the extent to which our genome has expanded and contracted had been underappreciated, masked by its relatively constant size over evolutionary time.

Humans aren't the only ones with elastic genomes. A new look at a virtual zoo-full of animals, from hummingbirds to bats to elephants, suggests that most vertebrate genomes have the same accordion-like properties.

"I didn't expect this at all," says the study's senior author Cdric Feschotte, Ph.D., professor of human genetics. "The dynamic nature of these genomes had remained hidden because of the remarkable balance between gain and loss."

Previous research had shown that genome sizes vary widely across different species of insects or plants, a telltale sign of fluctuation. This survey is the first to compare a diverse array of warm-blooded vertebrates, 10 mammals and 24 birds altogether. The study appears online in Proceedings of the National Academies of Sciences (PNAS) during the week of Feb. 6.

Trimming for Takeoff

When evolution repeats itself, there's usually a good reason. For most vertebrates it's not immediately apparent why genome deletions and add-ons typically go hand-in-hand. For flying animals, however, there could be a clue.

Feschotte's foray into the field began five years ago after his research had turned up a paradox. His group and others had found that the genomes of bats were littered with small pieces of DNA, called transposons, that had invaded and copied themselves throughout the flying mammals' genetic material. In particular, this massive transposon amplification had expanded the genome of a species called the microbat by 460 megabases, more genetic material than there is in a pufferfish. Yet the overall size of the bat's genome had remained relatively small in comparison to other mammals, suggesting that while transposons added new DNA, old DNA must have been removed somehow.

"These data begged the question: where did the old DNA go?" says Feschotte. In order to keep their genomes trim, he reasoned, these animals must have been good at jettisoning DNA.

In order to test the hypothesis, his team needed to quantify something that wasn't there, the amount of DNA lost over many millenia. Feschotte and the study's lead author Aurlie Kapusta, Ph.D., a research associate in human genetics, developed methods to extrapolate the amount of DNA that vanished by comparing genome sizes from present day animals to that of their common ancestors.

As they suspected, the microbat lost more DNA over time - three times as much - than it had gained since its divergence from a mammalian ancestor. This bat's cousin, the megabat, slimmed down its genome even more, losing eight times more than had been added.

The findings were a first clue that mammalian genomes were more dynamic than previously thought. But more than that, the data fit in nicely with an idea that scientists had been bantering around for a while. Animals that fly have smaller genomes. One reason could be that the metabolic cost of powered flight imposes a constraint on genome size.

Indeed, expanding the survey to include the bats' compatriots of the skies: woodpeckers, egrets, hummingbirds, and other birds, showed that the genome dynamcis of the two flying mammal species was more like that of the birds than the land-bound mammals. While most mammals trended toward an equilibrium between the amounts of DNA gained and lost over deep evolutionary time, the bats skewed toward shedding DNA over the same time frame.

The biological factors underlying the differences in genome dynamics observed across species are likely to be complex and remains to be explored. But whether streamlining genome content may have allowed flying animals to get off the ground is an intriguing proposal worth investigating, says Feschotte.

"If you look at small parts of the genome, or only one time point, you don't see how the whole genome landscape has changed over time," says Kapusta. 'You can see so much more when you step back and look at the fuller picture."

The work was supported by the National Institutes of Health, and will publish as "Dynamics of genome size evolution in birds and mammals" in PNAS on Feb. 6, 2017.

Explore further: First genome sequence of Amur leopard highlights the drawback of a meat only diet

More information: Dynamics of genome size evolution in birds and mammals, PNAS, http://www.pnas.org/cgi/doi/10.1073/pnas.1616702114

The first whole genome sequence of the Far Eastern Amur leopard is published in the open access journal Genome Biology, providing new insight into carnivory and how it impacts on genetic diversity and population size.

In rare instances, DNA is known to have jumped from one species to another. If a parasite's DNA jumps to its host's genome, it could leave evidence of that parasitic interaction that could be found millions of years latera ...

(PhysOrg.com) -- Researchers at The University of Texas at Arlington have found the first solid evidence of horizontal DNA transfer, the movement of genetic material among non-mating species, between parasitic invertebrates ...

Researchers from the University of Bristol have uncovered one of the reasons for the evolutionary success of flowering plants.

(Phys.org) It has long been known that birds and bats have small genomes, but the cause was uncertain. Now researchers at the University of New Mexico have shown that the genome shrinks over evolutionary time in species ...

In a contribution to an extraordinary international scientific collaboration the University of Sydney found that genomic 'fossils' of past viral infections are up to thirteen times less common in birds than mammals.

To the average plant-eating human, the thought of a plant turning the tables to feast on an animal might seem like a lurid novelty.

The widely condemned practice of ceremonial genital mutilation among girls and young women follows an evolutionary logic, according to a provocative study published Monday.

Evolution is often thought of as a gradual remodeling of the genome, the genetic blueprints for building an organism. But in some instance it might be more appropriate to call it an overhaul. Over the past 100 million years, ...

Conventional wisdom holds that sharks can't be harvested in a sustainable manner because they are long-lived animals. It takes time for them to reproduce and grow in numbers. But, researchers reporting in Current Biology ...

The ability of malaria parasites to persist in the body for years is linked to the expression of a set of genes from the pir gene family, scientists from the Francis Crick Institute and the Wellcome Trust Sanger Institute ...

A grisly method by which bacteria dispatch their distant relatives also creates conditions in which the attackers can thrive, research has found.

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Scientists Discover 83 Genetic Mutations That Help Determine Your Height – Huffington Post

Ever wonder how much of your height you inherited from your parents?

A large-scale genetic study published recently in the journal Natureis helping shed some light on the factors that determine whether a person grows to be 6-feet-1 or 5-feet-2.

While scientists already had a good idea of the most common genetic factors that contribute to height, the new findings uncover a number of rare genetic alterations that can play a surprisingly major role in human growth.

Using data from the Genetic Investigation of Anthropometric Traits consortium (a group also known as GIANT), scientists from the Broad Instituteat MIT and Harvard analyzed genetic information from more than 700,000 people, discovering 83 DNA changes that play a part in determining a persons height.

In their previous work, the same research team identified nearly 700 common genetic factors linked with height. Now, theyve identified a number of rare genetic variants for human growth that have an even larger effect than most common factors. For some people, these rare DNA changes may account for height differences of up to a full inch.

Overall, common variants still contribute more to height than rare variants, Dr. Joel Hirschhorn, the studys lead author and a professor of pediatrics and genetics at Boston Childrens Hospital and Harvard Medical School, told The Huffington Post. But, for the person who happens to carry one of the rare variants, the impact can be much greater than for common variants. For the variants we looked at, this was up to almost an inch... as opposed to a millimeter or less for the common variants.

Using a new technology called the ExomeChip, the researchers were able to scan the genomes of large populations to find rare markers that correlated with a particular height. They identified 51 uncommon variants found in less than 5 percent of people, and 32 rare variants found in less than 0.5 percent of the population.

With the addition of these uncommon variants, geneticists can now account for 27 percent of the genetics determining height up from 20 percent based on earlier studies.

Heritability is by far the largest factor contributing to individual height.

Today, in places where most people get enough nutrition in childhood to grow to their potential, about 80 percent or more of the variability in height is due to genetic factors that we inherit from our parents, Hirschhorn explained.

According to the studys authors, this method of testing rare genetic variants could be used to investigate uncommon DNA changes involved in other aspects of human health.

Looking at rare variants in genes was helpful in understanding the biology of human growth, Hirschhorn said. With a big enough study, similar approaches could be valuable in understanding the biology of many diseases, which could help guide better treatments.

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Scientists Discover 83 Genetic Mutations That Help Determine Your Height - Huffington Post

Genetic test to predict opioid risk lacks proof, experts say – Philly.com

It sounds like a godsend for America's opioid epidemic: genetic tests that can predict how a patient will respond to narcotic painkillers, as well as an individual's risk of misuse, addiction, and potentially deadly side effects.

Proove Biosciences of Irvine, Calif., claims its "opioid response" and "opioid risk" tests are the only precision medicine tools on the market to do all that, giving doctors information "to guide opioid selection and dosage decisions as well as treat side effects."

But while the concept is captivating, addiction researchers say it is not yet possible to use genetic variation to gauge the risk of drug abuse. And ECRI Institute, a Plymouth Meeting nonprofit center that evaluates medical technology, says Proove has not published independently reviewed studies to support its claims.

"We cant say it doesnt work. All we can say is, theres no evidence it does," said ECRI research analyst Jeff Oristaglio.

In an interview, Proove CEO Brian Meshkin defended his five-year-old products, which he said retail for $1,000 a test and were used by about 400 doctors last year in treating 50,000 patients. He said he expects scientific journals to publish results from studies "within the next six months." Three clinical trials of the opioid response test are ongoing.

Consumers may assume that such high-tech genetic tests have to demonstrate safety and effectiveness to win regulatory approval, but they do not. Even though these complex diagnostics use the latest gene-sequencing and data-crunching techniques, they can come to market under 1988 federal regulations designed to ensure the quality of clinical laboratories.

Two years ago, the U.S. Food and Drug Administration proposed a new framework for overseeing "lab-developed tests" that would take into account their complexity and riskiness, because inaccurate or false results can harm patients. But the agency withdrew the controversial proposal after the November election, saying it needed "to continue to work with stakeholders, our new administration, and Congress."

Proove is one of many companies in the fast-growing genetic-susceptibility testing market, a multi-billion industry built on trying to foresee and thus, forestall disease, disability, and death.

Opioid-related deaths have become an urgent public-health crisis. Every day, on average, 3,900 people start abusing prescription painkillers, 580 graduate to cheaper heroin, and 78 die of a narcotic overdose, according to federal data.

In theory, genetics provides an opportunity to reduce this toll. Researchers have linked a predisposition to opioid dependency to gene variants involved in the brain's signaling of reward and pleasure. Addictive behavior, particularly alcohol abuse, is known to run in families.

But addiction experts say risky behavior involves the largely unpredictable interplay of environmental, cultural, and biological factors.

"It is hard to conceive of a genetic test or a genetic score that would be valuable as a predictor of opiate abuse or addiction in general," said Michael Vanyukov, a University of Pittsburgh professor of pharmaceutical sciences, psychiatry and human genetics.

Vanyukov, who wasn't familiar with Proove's products, said heredity plays a relatively small role in determining variation in addiction risk, while choices and perceptions can play a big role. "If the individual is informed of, say, a 'low' risk score, this very piece of information will change the risk. The error of a genetic score is likely to be great, and reliance on it in practice may be dangerous."

Psychiatrist Charles OBrien, founding director of the University of Pennsylvania's Center for Studies of Addiction, was also unfamiliar with Proove's test, but echoed that sentiment: "I could not in good conscience recommend that someone spend money on these tests."

O'Brien's own center recently identified gene variants associated with response to naltrexone, a drug that blocks the intoxicating effects of alcohol. But when the center studied alcoholics on naltrexone, strong and weak responders had the same number of heavy drinking days.

"We were very disappointed because we're all looking for precision medicine," O'Brien said.

Proove's tests analyze DNA from a cheek swab. The opioid risk test gives the patient a score low, moderate, or high risk of opioid abuse that is based on detecting variants in 12 genes, combined with clinical information such as a history of depression. The company's website claims the algorithm is 93 percent accurate.

But when ECRI scientists looked to validate that claim, all they could find were brief summaries of two studies that the company presented at medical conferences. One studyof 290 patients compared the Proove risk test with the "opioid risk tool," a standard, one-minute screening questionnaire that doctors use to ask chronic pain patients about risk factors such as a history of mental illness or substance abuse.

"We cannot determine ... whether the test performs better or worse than the opioid risk tool in predicting opioid misuse," ECRI concluded.

Insurance plans either consider Proove's tests unnecessary or have no specific policies, ECRI found, although Meshkin said insurers are covering the cost "on a case-by-case basis."

"At some point, you've got to stop and produce the evidence if you want people to pay," said Diane Robertson, director of ECRI's health technology assessment service. "Why would anyone want to use something if there is no evidence that it has benefit?"

Published: February 6, 2017 10:09 AM EST The Philadelphia Inquirer

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Genetic test to predict opioid risk lacks proof, experts say - Philly.com

Studies point way to precision therapies for common class of genetic disorders – Princeton University

Two Princeton University studies are opening important new windows into understanding an untreatable group of common genetic disorders known as RASopathies that are characterized by distinct facial features, developmental delays, cognitive impairment and heart problems. The findings could help point the way toward personalized precision therapies for these conditions.

Although not widely known, RASopathies are among the most common genetic disorders, affecting approximately one child out of 1,000. RASopathies are caused by mutations within the RAS pathway, a biochemical system cells use to transmit information from their exterior to their interior.

"Human development is very complex and it's amazing that it goes right so often. However, there are certain cases where it does not, as with RASopathies," said Granton Jindal, co-lead author of the two studies. Both Jindal and the other co-lead author, Yogesh Goyal, are graduate students in theDepartment of Chemical and Biological Engineeringand theLewis-Sigler Institute for Integrative Genomics (LSI). Jindal and Goyal do their thesis research in the lab ofStanislav Shvartsman, professor of chemical and biological engineering and LSI.

"Our new studies are helping to explain the mechanisms underlying these disorders," Jindal said.

These studies were published this year, one in the Proceedings of the National Academy of Sciences (PNAS) and the other in Nature Genetics online. The researchers made the discoveries in zebrafish and fruit flies animals commonly used as simplified models of human genetics and Jindal and Goyal's specialties, respectively. Due to the evolutionary similarities in the RAS pathway across diverse species, changes in this pathway would also be similar. Thus, it is likely that significant parts of findings in animals would apply to humans as well, although further research is needed to confirm this.

The first paper published Jan. 3in PNAS presented a way to rank the severity of different mutations involved in RASopathies. The researchers introduced 16 mutations one at a time in developing zebrafish embryos. As each organism developed, clear differences in the embryos' shapes became evident, revealing the strength of each mutation. The same mutant proteins produced similarly varying degrees of defects in fruit flies. Some of the mutations the researchers tested were already known to be involved in human cancers. The researchers noted that these cancer-related mutations caused more severe deformations in the embryos, aligning with the medical community's ongoing efforts to adapt anti-cancer compounds to treat RASopathies.

"Until now, there was no systematic way of comparing different mutation severities for RASopathies effectively," Goyal said.

Jindal added, "This study is an important step for personalized medicine in determining a diagnosis to a first approximation." The study therefore suggested a path forward to human diagnostic advances, potentially enabling health care professionals to offer better diagnoses and inform caretakers about patients' disease progression.

The study went further and examined the use of an experimental cancer-fighting drug being investigated as a possible way to treat RASopathies. The researchers demonstrated that the amount of medication necessary to correct the developmental defects in the zebrafish embryos corresponded with the mutation's severity more severe mutations required higher dosages.

The more recent paper, published online by Nature Genetics Feb. 6, reports an unexpected twist in treatment approach to some RASopathies. Like all cellular pathways, the RAS pathway is a series of molecular interactions that changes a cell's condition. Conventional wisdom has held that RASopathies are triggered by overactive RAS pathways, which a biologist would call excessive signaling.

The Nature Genetics study, however, found that some RASopathies could result from insufficient signaling along the RAS pathway in certain regions of the body. This means that drugs intended to treat RASopathies by tamping down RAS pathway signaling might actually make certain defects worse.

"To our knowledge, our study is the first to find lower signaling levels that correspond to a RASopathy disease," Goyal said. "Drugs under development are primarily RAS-pathway inhibitors aimed at reducing the higher activity, so maybe we need to design drugs that only target specific affected tissues, or investigate alternative, novel treatment options."

The Nature Genetics study also found that RAS pathway mutations cause defects by changing the timing and specific locations of embryonic development. For example, in normal fruit fly cells, the RAS pathway only turns on when certain natural cues are received from outside the cell. In the mutant cells, however, the RAS pathway in certain parts of fly embryo abnormally activated before these cues were received. This early activation disturbed the delicate process of embryonic development. The researchers found similar behavior in zebrafish cells.

"Our integrative approach has allowed us to make enormous progress in understanding RASopathies, some of which have just been identified in the last couple of decades," Shvartsman said. "With continued steps forward in both basic and applied science, as we've shown with our new publications, we hope to develop new ideas for understanding and treatment of a large class of developmental defects."

Princeton co-authors of the two papers includeTrudi Schpbach, the Henry Fairfield Osborn Professor of Biology and professor ofmolecular biology, andRebecca Burdine, an associate professor of molecular biology, as well as co-advisers to Goyal and Jindal; Alan Futran, a former graduate student in the Department of Chemical and Biological Engineering and LSI; graduate student Eyan Yeung of the Department of Molecular Biology and LSI; Jos Pelliccia, a graduate student in the Department of Molecular Biology; seniors in molecular biology Iason Kountouridis and Kei Yamaya; and Courtney Balgobin Class of 2015.

Bruce Gelb, a pediatric cardiologist specializing in cardiovascular genetics and the director of the Mindich Child Health and Development Institute at the Mount Sinai School of Medicine in New York, described the two new studies as "wonderful" in advancing the understanding of altered biology in RASopathies and developing a framework for comparing mutation strengths, bringing effective treatments significantly closer.

"At this time, most of the issues that arise from the RASopathies are either addressed symptomatically or cannot be addressed," Gelb said. "The work [these researchers] are undertaking could lead to true therapies for the underlying problem."

The paper, "In vivo severity ranking of Ras pathway mutations associated with developmental disorders," was published Jan. 3 in the Proceedings of the National Academy of Sciences. The paper, "Divergent effects of intrinsically active MEK variants on developmental Ras signaling," was published on Feb. 6 in Nature Genetics online. The research for both papers was supported in part by the National Institutes of Health and the National Science Foundation.

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Studies point way to precision therapies for common class of genetic disorders - Princeton University