Medical Schools React to the Opioid Crisis With Curriculum Changes – WKSU News

Over the last two decades, about 2 million people in the U.S. became addicted to opioids after being prescribed pain killers following an injury or illness. The National Institute on Drug Abuse and other studies say an increased emphasis on pain-management two decades ago contributed to an increased reliance on prescribing opioids. In this installment of our series, Opioids: Turning the Tide in the Crisis, WKSUs Kevin Niedermier looks at what role this has played in the deadly epidemic and how it is changing the way medical students are being taught.

Training doctors on alternatives to addiction

An estimated 76 million Americans suffer from chronic pain.

One new doctor who's learned better ways to treat that pain is Elliott Schwartz. He graduated from the Case Western Reserve medical school and is doing his residency at St. Vincent Charity Medical Center in Cleveland. He says looking for a past history of addiction in patients is one key, be it opioids, alcohol or other substances. And, he says that means convincing patients there are alternatives.

Medical students hope changes will help I think as people realize there are ways to manage pain without these strongest pain killers, without these opioid medications, well probably see a shift away from this chronic use of opioid meds.

Schwartz took a relatively new, but optional fourth-year class at Case on responsibly prescribing pain medication, a reaction to the epidemic. It's taught by Dr. Ted Parran who specializes in addiction medicine. Parran says about 20 years ago, leaders in the medical profession decided that serious pain -- including long-term pain -- should be aggressively treated. And, they agreed that opiates seemed to be one good way to do that.

He says this war on pain coincided with other factors to help create todays opioid problem.

Making pain treatment a priority Health-care organizations were being told to screen for pain, and if its there, assess it, and if its serious, treat it. Not necessarily with opiates, but treat it.

"And then, finally, patients satisfaction surveys started coming out routinely at exactly the same time, and it really was the perfect storm. If you want patients to be satisfied treat their pain, the quickest way to treat their pain and the simplest is to just give them opiates.

Parran says the roughly 1-in-10 patients who are most likely to become addicted due to their brain chemistry dont begin showing the signs for one to two years. It's a time during which they are building up a tolerance to the drugs. But initially, studies on patients being treated with opiates were nonexistent after three-to-six months, and it seemed like everything was working fine.

Opioidsseemed like a safe, effective answer After people had been on these meds for a year, year and a half or two years -- and now were chewing them and selling them and buying them on the street and switching to heroin and doing all these awful things and having all these terrible overdoses -- the cat was out of the bag already.

NEOMED, the Northeastern Ohio Medical University, also offers a course on pain management and de-emphasizing the use ofopioids. It was established about four years ago in response to the epidemic. Dr. Bill Smucker, who teaches the course, says there are better alternatives to opioids for chronic pain.

Mind control and other methods The approaches that work include you doing mind- control things, and by that I mean deep breathing, relaxation, doing physical therapy and exercise, perhaps doing cognitive behavioral therapy with a psychologist or a behavioral -health consultant.

But, Smucker says patients are resistant to that approach.

I think the most important thing were teaching right now is to begin to teach physicians to begin to teach patients that were going to begin to make a shift from, Im giving you pain medication while you have your broken bone, but the pain is going to be your responsibility, it is going to shift be more your responsibility. Of course Ill help you, but opioids are not the single, simple fix for it.

A tough doctor-patient discussion Nakle Singh is a third-year student at the Case medical school. He recently attended a lecture by Parran on addiction; the class focused on addiction and prescribing pain killers will come in Singhs fourth year. He says hes aware of the opioid crisis, and during hospital rounds hes seen how difficult it can be to reduce dependence on pills.

Those conversations come up with attending physicians, and theyre usually very awkward encounters to witness because there really is a struggle between provider and patient."

But med schools across the country have recognized that that conversation needs to change.

The Association of American Medical Colleges says almost all of the approximately 140 medical schools in the U.S. now offer courses de-emphasizing the prescribing of opioids and other powerful pain killers.

More here:

Medical Schools React to the Opioid Crisis With Curriculum Changes - WKSU News

Freedom and Liberty Through the Eyes of a Christian: – The Liberty Web English

Interviewer: Hanako Cho

Interviewer (I): Lord Actons words absolute power corrupts absolutely are very famous, but Japanese people dont know much about him. So would you please share with us your knowledge about him?

Mr Jayabalan: Sure. The full saying of what he said was: power tends to corrupt and absolute power corrupts absolutely. So not all power is corrupting, but its the absolute nature of power. Lord Acton was known for many witticisms. He had a very quick wit when it came to being able to put pithy statements together that expressed a truth a profound truth about politics, or religion, human liberty. He was an English historian 19th century a contemporary of Cardinal Newman (now Blessed Cardinal Newman) who was also a very famous figure at the time. So there were a lot of political religious elements being discussed and debated quite a bit.

As always in Europe, the French revolution was a key topic of his thought. And unlike more proponents of the French revolution, Lord Acton had thought that the history of liberty coincided with the history of Christianity, that Christianity and human liberty grew together. And, of course, this was opposed to what many of the more radical proponents of the revolution had said, that Christianity, and especially Catholicism, needed to be eliminated in order for human beings to be truly free.

Lord Acton was a Roman Catholic himself from an old English Catholic family which had roots in many other European countries. So he happened to be born in Naples, Italy, just south of Rome. He studied in Germany because at the time he would have studied at the universities in the United Kingdom, Catholics were not allowed. After the English reformation, lets call it, Catholics were looked at as not being loyal citizens of the Crown, and therefore somebody like Lord Acton studied in Bavaria. But, in a way this expanded his knowledge of European affairs quite a bit.

So Lord Acton was probably one of the most prolific, lets say, public intellectuals or writers of his day. He wrote book reviews lengthy book reviews of virtually every important book that came out during his lifetime. He had things to say, opinions to offer, on virtually every political happening. And, of course at this time in the late 19th century both Germany and Italy were unified into the nation states that they are today. And so nationalism was a big subject of his when he wrote. The nationalist movements that were taking place all through Europe. Everything happening after 1848. Liberalism, lets say modern liberalism or classical liberalism, depending on your viewpoint, were often the subject of his writings. But as I said before, especially the relationship between Christianity and liberalism and liberty and to what degree to they reinforce each other, to what degree to they improve each other, to what degree are they opposed to each other. These were the major topics of his writings.

(I): So what do you say about French Revolution and American Revolution?

Mr Jayabalan: Well, its hard to say any one thing about the French Revolution and the American Revolution. Theyre vast its probably revolutions plural when it comes to France. And America, for that matter. And in many ways the French revolution is still unfinished its still taking place.

(I): Its still staking place? In what sense?

Mr Jayabalan: Well, apparently a Chinese public intellectual has said this. I dont remember who the figure was, but when he was asked for his views of the French revolution, he said its too soon to tell. So, liberalism is an ongoing project, I would say. And especially in France. Weve had five republics since the French revolution and the French say that there will always be a sixth coming. So you never know what kind of crises are happening.

I think Acton, like many Englishmen, was more skeptical about the French revolution than other Europeans were. The English and the French have always had a bit of a rivalry politically and culturally, and so I think the English tried to moderate some aspects of the French revolution. Edmund Burke, you think of Bourkes writings, his reflections on the revolution in France, were so extreme from the continental point of view that he broke with the Whig Party. And, in many ways Acton was a Catholic Whig. He believed in progress, he believed in human liberty, but he also believed in enduring first principles. He believed that the Catholic Church was the true church, the true religion, and so how that reconciles with human liberty was always a question.

I think Lord Acton was a very admirable man in the sense that he was very positive about human liberty. He didnt try to deny human liberty he thought that human liberty was a risk worth taking and that civilization would improve as a result, so long as it was liberty combined with responsibility. Hes famous for saying: liberty is not just the power to do what one wishes, but the right to do what one ought.

Theres a moral element to freedom. And that there is a right and wrong way of using your freedom. And so I think Lord Acton this was true both for individuals and for societies. So in many ways he was trying to promote this idea of moral responsibility and human freedom being used for the common good, and that human freedom had not always been properly valued, lets say, by especially political authorities. That hasnt changed so much.

As a result, Lord Acton was a precursor for what many of us who work in the think-tank world in the United States and Europe would have liked to have done, both at his time when many of these events were taking shape. As I said, the unifications of Germany and Italy and the French Revolutions and all these things were happening at that time. So, he was a very important figure, especially for his time. Hes probably not as well known as he should be these days, partly because, he never finished his magnum opus, his great work; his great historical study on the history of liberty was never completely finished and therefore wasnt published during his lifetime. And so theres no one work we can go to and say this was Lord Actons greatest writing. People know his witticisms, as I said. So he was known much more for pithy remarks and his opinions on things, rather than one major work.

(I): So you are director of Acton Institute? What is the mission of Acton Institute?

Mr Jayabalan: Im the director of the Acton office in Rome. The Acton Institute is a think-tank based in Grand Rapids, Michigan, which has been around since 1990 with the primary mission to help educate religious leaders in economic thought. To help people who guide religious organizations and religious congregations, or even have a religious, lets say, interpretation of life to try to understand how economics relates to how religious people look at the world, especially when it comes to Christianity.

Theres a widespread opinion that Christianity is opposed to wealth or to riches, partly because there are many things in Christianity in the New Testament especially that seem to be critical of riches: its harder for a rich man to enter Heaven than for a camel to pass through the eye of a needle, for example, or the parable of the rich man and Lazarus. There are many instances in which Christianity certainly does make a virtue of poverty. It does try to hold the voluntary vow of poverty by religious people as a good thing that frees them for more spiritually devoted lives. But, as a result, people think, well, we should all be poor. Its the voluntary aspect of taking a vow of poverty that often gets lost.

So, we have a paradox. On the one hand we have this virtue of poverty when its individually taken or a religious order takes it on, but we also as Christians think that poverty is scandalous. So its both a virtue and a scandal. Theres a little bit of a dichotomy when it comes to how Christians look at poverty. As a result, many misinterpretations of Christianity have taken place. One, for example, was called Liberation Theology, which was a movement that flourished in the 1970s and 1980s. To put it very briefly, I would say it was an amalgamation a synthesis of Marxism and Christianity, Marxism especially as understood by Europeans, but exported to Latin America. It was a way of trying to correct the inequalities, social, economic and otherwise, that were often found, and are still found in Latin America, by trying to take the Christian message and politicize it make it very worldly.

Well, whats wrong with a worldly message, you might ask. Jesus, of course, as God and man was expected to be a king. And, indeed, he was a king. He is a king. But not in the way that, lets say, many Jews of his time, and I would say even people today, would understand. Christ is famous for saying his kingdom is not of this world. And so there is an aspect that Jesus did not rule as other kings have ruled. He did not accede to power the way a Caesar would, or the way a Napoleon would, or the way even a President in a modern republic would. He remained a very spiritual figure, away from politics.

So the question is how are Christians supposed to live politically? How are we supposed to live together? And that, I think, Christianity has always left up to the vagaries of history, circumstances, the way people interpret the needs of their day and age, and in many ways Christianity has said these things will happen as they happen, but the most important things are of an interior, spiritual nature. How we live in the world, rather than how we structure society in order to bring about the kingdom of heaven, which has always been looked at with some doubt that thats possible. And that God is ultimately in charge. That our politics are important, very vital to promoting the common good and social cohesion, but ultimate God is all powerful, all knowing, he exists outside of time and space so these things have already been decided in many ways, even though we have the free will to take that path. To decide whether we want to follow Gods ordained path for us or decide to go our own way. And this has always been the big question about human freedom. Is it a manifestation of human pride in the face of God and his authority, or is it a way of exercising the freedom that God has given us for greater purposes, in order to love and know God better. And so this has always been the debate, I think, about human freedom.

We try to apply that concept to economics. What can economics do to promote a healthy and virtuous society? What can economics do to help people live, not only materially better, but also spiritually. Are there things about economics that we understand from the study of economics that can improve society and make us all feel that were more fulfilled, living more in line with human dignity. What does economics have to teach us about these things is what we try to help religious leaders think about, not necessarily having answers to, but think about these things in a way that they probably wouldnt have if nobody had brought up the issue of economics with them.

(I): This is very interesting. I found an article, WSJ, Wall Street Journal, which talks about the Church of England very high returns because Church is company that would produce profit coincide when viewed from Gods perspective. Its really interesting. So, how can we make sure the market that could produce the products or profits viewed from God, because something that sells well doesnt necessarily have high added value viewed from God. So, how can we make sure of that?

Mr Jayabalan: Well, the way we make sure any of our activities are in line with Gods wills and purposes. We have to be very intentional in what we do. To think that our activities have some bearing on the world. And that we have some responsibility. That each of our activities in the market place, whether its producing, consuming, investing, whatever it may be, has some moral component to it.

There are times wheninvesting in company A or investing in company B, theres not so much of a moral element to it. Lets say they are two companies that are relatively equal and producing similar goods and services. Its a prudential decision on the investors part which to invest in. Its not necessarily a moral principle. But I would say overall we have to perceive what we do as contributing to the common good. And its that concept of the common good thats often lost.

Many market economies are liberal democratic societies in which individualism the individual is considered the authority. Nobody can tell an individual what to do, or so its claimed. So as a result, any kind of moral claims, anybody who says someone should or should not do something the ought question that I mentioned with Lord Acton is considered out of place. Who are you to judge? Who are you to tell me what to do? This idea that the individual is the best judge of his own affairs. And, of course, that is a little bit of a problem because anybody with a little bit of experience and common sense knows that people make mistakes all of the time.

The individual is rarely the best judge of his own affairs. Thats why we have mentors and teachers and spiritual directors, and thats why people look for guidance all the time. Anybody who goes to a bookstore, insofar as they still exist, if you go to Amazon and look at some of the best sellers its not surprising that in western individualistic societies individual self-help books are often very popular. And in a way I think thats a concession that freedom is not enough, freedom is not sufficient. Somebody could say, Im going to respect your freedom so much that Im going to leave you so alone that I dont need to care about whether youre living a virtuous life or not.

So as a result were kind of caught between wanting to be an authority unto ourselves as individuals, and knowing that were very weak and fallible and nothing particularly admirable when it comes to being individuals. Were lost sheep without a shepherd in many ways. So often were looking for shepherds. Christianity is often neglected, but that very language is from Christianity sheep without a shepherd is what Jesus says. And so people dont know where to go, and so theyre always looking for other ways of fulfilling theyre everyday activities, for giving their everyday activities some purpose in the overall sense of life and the order of things. And, as a result, people are always asking questions and looking for answers.

So [at Acton], on the flip-side we like to also help business people and these days in our advanced societies almost everybody is a business person of some sort. We all buy and sell things. We all go shopping. Were all investors insofar as were probably middle class and above. What does all this have to do with life? All the big questions, why we exist and what we are supposed to be doing here. So, again, we try to bring these aspects together the material and the spiritual without neglecting one or the other, or denigrating one or the other, because one without the other is somehow less human. Life would not be as rich, would not be as rewarding, if we neglected one aspect at the expense of the other.

Sothis is some of the things that we like to do. Its not always popular. I would say that, quoting our co-founder, Father Robert Sirico: many religious traditionalists think were crazy libertarians, and many libertarians think were hoary traditionalists. Were somewhere in between those two camps. I think the most important thing is to think about how human beings actually are. Human beings have both these sides to them. This desire to be independent and self-governing, as well as a realization that we actually dont know as much as we claim to. We dont know what is best for us. Its a very difficult, long process to educate oneself, and a life-long one, and one that certainly the western tradition has tried to maintain. If you look at eastern societies, the very traditional aspects of eastern cultures and eastern civilizations stress authority, the realization that individuals are not the best judges of their own affairs.

(I): In the presidential campaign Mrs Clinton claimed that Catholic Church needs to have Catholic spring. Have you ever heard of that?

Mr Jayabalan: I dont think it was Clinton; it came out in the emails that her Chief of Staff had been exchanging with some of her campaign workers. But it wasnt Clinton herself. Still, people around her were saying there needs to be a Catholic spring.

(I): Because of its backward views on pro-life? But being a religious organisation

Mr Jayabalan: I think on life, and on women, I think it has to do with women in general. So many of the criticisms of the Catholic Church are not so much about the Trinity or the resurrection of Jesus or the nature of Christ, but they often have to do with the church has to say about women, especially when it comes to sexual ethics. So, lets just narrow it down to what really seems to get people upset these days. Its a very narrow preoccupation. Because the Catholic Church doesnt go along with popular culture and modern culture as its currently constituted, people think its just simply reactionary. And anybody who becomes a Catholic, myself included, is looked at as being somebody whos a secret authoritarian, a closet authoritarian, who wants to tell people what to do. I think thats not exactly the case. We respect human freedom. We know that human beings are free to choose wrongly and make bad decisions. We know that. And that sometimes its better to let people make bad decisions and learn from them rather than trying to save them from themselves. We fully understand that.

The Clinton emails, well her campaign her staff emails that were released through Wikileaks reveal something that most of us in the United States have known for a long time, that the Democratic Party which was once the home of most Catholics in America has moved further and further away from the Church over the last 30, 40 years. And its very hard now to find Catholics who believe all that the church says and remain in the Democratic Party. And I think those emails just revealed that.

(I): Yes, as a religious organisation we are pro-life, not pro-choice, because the soul reside in mothers womb in the later period of pregnancy. So we believe that. So that is why we are so pleased that Hillary Clinton was not chosen by U.S. citizens this time.

Mr Jayabalan: Yeah, theres more to it than just abortion, but the abortion issue was what drives a lot of the religious vote towards the Republican Party. But this is actually a new phenomenon. The Republican Party before Ronald Reagan was a pro-abortion party and the Democrats were the pro-life party. This was one of the ironies of history, how the Democratic Party went from being the pro-life party to being the absolute pro-choice pro-abortion- party. And its very unusual to think about how this happened. I think if you thought about this 40 or 50 years ago theres no way you would have guessed that the Democrats would have become the pro-choice party. The Republicans, who were looked at as a very white, Anglo-Saxon, Protestant party, who didnt particularly care about abortion issues and would have liked probably to have seen fewer babies being born in the name of, kind of, social manners and population control and health and all of these kind of things, they are now the pro-life party. And this was primarily due to Ronald Reagan himself, who as Governor of California had liberalized abortion laws, and came to change his mind, had a change of heart, and realized that abortion was indeed a great evil on society and that it needed to be fought. And so as a result the Republican Party has become the pro-life party.

(I): I see. So going back to the Lord Actons remarks. He said that absolutism and autocratic government will not continue forever because its very difficult to keep the absolute submission for a long time. So, viewed fro this standpoint, how do you see North Korea and China?

Mr Jayabalan: How do I see?

(I): How do you see

Mr Jayabalan: China?

(I): North Korea and China

Mr Jayabalan: Yeah. What was the first part? China and?

(I): North Korea and China. Because Lord Acton said its going to be really difficult to keep the autocratic government forever.

Mr Jayabalan: Yeah, once people get a taste for human freedom its very difficult to limit it. And this is, again, a problem of liberalism. So, you may have had, lets say, traditional mores in a society and then as people start to become more and more aware of their human freedom they start to question these things and sort of say, well, are we doing this just because we were told this is the right thing to do and therefore we need to question. And thats very much a double-edged sword. On one hand its a very good thing because it helps keep government authorities honest. It helps people realize that just because somebody is richer or stronger or has more power, that does not entitle them by itself to enforce their will upon others. And they have to respect individuals as free and equal human beings. But at the same time, as I was saying, with liberals, they have a hard time recognizing anybody has any kind of authority. So therefore, we have to rethink and come up with our own morality every single day. Theres no reliance on what we already know and what has already been decided.

So, as a result of this, a place like China, which has started to liberalize, will probably try to keep the lid on political control while maintaining some kind of economic freedom. But again thats a very strange thing to do, because if you think about state capitalism, to what degree are people really free in that kind of system? Material wellbeing by itself is not a manifestation, lets say a manifestation of freedom. If somebody wants to give you all your needs, provide all your needs for you, which is what communism wanted and socialism has always said that the government can do, youre not really free people dont really feel like theyre exercising their free will and their moral responsibility to live as they wish to live. And eventually those kinds of systems tend to break down. Partly because it doesnt respect human freedom, and party because it exaggerates the capability of authorities to manage a large modern economy.

Friedrich Hayek talks about this in The Problem of Knowledge in Society. There is no one human being in any kind of government or bureaucracy or central planning agency that knows all the factors of production, all the supply and demand aspects of an economy, even a small one. And therefore they cant set prices or decide where resources ought to be allocated and things. Its better to let individuals do those kinds of things. Now, you can let individuals be free economically within certain parameters, called the rule of law in a very general sense, that its wrong to steal, its wrong to take anothers property and then when we have contracts they ought to be enforced, and if we have disputes we can take them to an authority the court system. Theres always this mix between freedom and authority in any society. Theres never been a completely authority-less society in which people decide everything for themselves as they go along. So this is the problem. People dont know where to turn for [authority].

What happens in more authoritarian societies, which are often based on a different type of anthropology, a different understanding of human beings, that human beings are not free by nature, that they need to be treated, in a way, like cogs in a machine and organized in a different way. That is not a way of achieving human fulfillment and the flourishing of human nature. But, again, if it doesnt really reflect human nature its not going to work and I think both, theanarchist way of looking at things, as well as the authoritarian way of looking at society, neither of those fully reflects the drama of human life and what were here to do.

(I): Last January in 2015 in France there was incident called Charlie Hebdo, you remember?

Mr Jayabalan: Charlie Hebdo, yes

(I): Yeah, Charlie Hebdo

Mr Jayabalan: Yeah, the shooting at the offices of the magazine, yeah.

(I): Yes. And, at that time, people argued that the freedom of speech surpasses the right of freedom of faith. French people argued in that way. So, as a religious organisation, we are very much, we felt, very, a strange feeling. Is there superiority between the two rights? Is there any superiority between the two rights?

Mr Jayabalan: Well, its the same question about freedom and responsibility.

(I): Oh yes.

Mr Jayabalan: Free speech often has to do with political speech and religious speech. So, I think its ridiculous to say that Charlie Hebdo ought to be shut down, or Islamic terrorists can go in and shoot them because they dont like what they say about Islam. Thats not the way a free society operates, obviously.

At the same time, I know what you mean, and we dont like to see religious beliefs insulted, but thats part of free speech. If you dont like it you have to defend it yourself. And, in a way I tend toward the free speech side on this just because I dont know how you would control things in a way that respects human freedom. But in no way can you allow I mean Charlie Hebdo was not a fan of any religion they insulted Christianity, they insulted Judaism, as well as Islam.

So, freedom comes with a responsibility, again, and if you are going to attack peoples very deeply, seriously held religious beliefs you will pay a price for it. Now it might not, it shouldnt be with your life, but they should be free to be criticized. They should be free, but our society should be able to say what is beyond the pale. We do that with all kinds of speech. Free speech is not an absolute in any way. Youre not allowed to incite violence using free speech, youre not allowed to say false things about another human being we have laws against slander and libel and defamation. So, again the absolutists on free speech, I think, are wrong. They have exaggerated their case. But religious fanatics like these who attacked Charlie Hebdo were completely out of place. They clearly dont understand the rules of French society. They dont want to play by those rules, and I think that France is completely justified in telling people who live in their country, and especially if youre going to be a French citizen, that these are the rules you play by. You have to learn to respect opinions that you dont agree with, and if you dont you have no business being in France.

(I): I see. Id like to ask you about your take on Trump administrations trade policy.

Mr Jayabalan: Well, having followed the US election campaign, which seemed to go on forever and ever in the United States, I think there were some interesting things being said about free trade. For the first time in my adult lifetime both parties seemed to be against free trade agreements, lets call them.

Now, I guess the big question is, Is a free trade agreement the same thing as free trade itself? I think this is one of the cases that Donald Trump was making during the campaign was that the North America Free Trade Agreement which, of course, Bill Clinton had signed into being along with a Republican Congress. When Bill Clinton did that he was being a New Democrat. The Democratic Party, which has traditionally been supported by trade unions, was very skeptical of free trade agreements. Now with the environmentalists being a big part of the Democratic Party, they tend to be skeptical of free trade agreements.

The left had always been against free trade agreements because they didnt like to see the market economy being expanded, they wanted it to be controlled, especially when it came to labour and the environment. The right, the free market right, let me put it this way, had criticized some of these agreements because they tend to be forms of crony capitalism, of setting out legislation that protects some industries and doesnt protect other industries. Its not really a free trade agreement in that regard. And then there are some from the more, lets say, nationalist right that dont think that the government should favour the rights of foreign workers just because they happen to have lower costs than their own workers. There are a number of elements at play here and I think whats important is that we maintain the idea that free trade is good, not only for the United States, but for the rest of the world.

The United States since the end of the second world war has had quite a bit invested in maintaining a free trade regime while the United States also supplies security, both for trade and for nations to exist and to promote this type of global order in the world. The United States has put tons of money and equipment and effort into maintaining this and Donald Trump is now questioning that, whether this is whats necessary in the twenty-first century.

Theres been a backlash against what we call economic globalization, trade and immigration are not looked at as unqualified goods. Which of course theyre not as no good is completely unqualified. Again, we shouldnt be absolutist or dogmatist or religious about free trade arguments. We should look at them practically and look at whether they actually do promote what we would call the common good. Are they actually good for us as a society?

The Democratic Party to me was quite striking that Bill Clinton who signed NAFTA Hillary Clinton was all over the place when it came to the TPP. She never really had a principled argument to make about it, and I think this is probably the reason why she lost the election. Nobody really knew what she stood for. Where Donald Trump said very clearly, My responsibility is to the American people and especially those who have been forgotten. And that seemed to have won the argument, especially in those states which made the difference in the US election, which happens to be where I am from: Michigan, Wisconsin, Ohio, Pennsylvania, what we call the former rust belt, where the manufacturing base has been tremendously damaged, not only because of free trade but because of technology and advances we have made when it comes to producing manufactured goods. Not only do you have [inaudible] lower labour costs [abroad], but we have technology that makes many workers redundant. And, without retraining workers and providing new opportunities for those who are negatively affected by progress, globalization is going to be on very shaky ground politically speaking.

(I): So you say that its important to differentiate between the free trade agreement and free trade. It needs to have fair trade, as

Mr Jayabalan: Well, I dont like the term fair trade either, because that implies that we know what a fair outcome of an economic agreement is. Often times we dont, and thats why we allow for free trade for the parties involved to come to an agreement themselves. So, I mean, as far as I can tell, Trumps argument on TPP was that, were making deals with countries who are not playing by the same rules.

(I): Like China

Mr Jayabalan: Yes,for example, Chinas currency manipulation. They purposely hold down the value of their currency so that they can sell more goods to the United States and make American imports into their country more expensive. And then you have a big trade deficit. That to Donald Trump is the real problem. So I think we need to see what he does. He promises to have tougher negotiators, which may be a good thing. I tend to think that if you want to have a free trade agreement it should be fairly simple;were going to reduce our barriers to entry into our country, and thats it, quite simple. Reduce the tariffs. Make it easier to trade. And nothing more. No carve-outs for certain industries, no favours given. But again that might be a little bit unrealistic because all politics is like that. All countries will want to protect certain industries, partly for national defence and security reasons. And, so you cant allow everything to be decided by economics. The nationalists have a point there, as do the free traders.

(I): I see. So do you believe American economy will grow?

Mr Jayabalan: I think so. The left in America has had, certainly under President Obama, no idea of how to get an economy moving again. They tend to rely on the government to grow an economy, and we know that doesnt work. They say, of course, they want the government to assist the market, which would be fine so long as you dont crowd out private initiative and innovation and entrepreneurship, all of the things that have been missing in the American economy for at least the last decade or so. Trump understands business better. He understands the attraction of making good business deals and getting growth and building things, so hopefully hell understand that what America needs to do is reduce the burden of government on business. Cut corporate

(I): Deregulation

Mr Jayabalan: Cut corporate taxes, cut regulations, make it easier for market economies to operate. And let people try to create new opportunities and if they fail they fail, but keep trying. This is how a market works. The Democrats, with their nanny state way of thinking, they want to coddle everybody and make sure that everybody advances equally, and if somebody happens to advance more rapidly than another, we have to hold them down until everybody rises up and eventually nobody does. And I think thats the real problem with the way the left looks at economics these days.

(I): So thats why many American pundits criticize Donald Trump?

Mr Jayabalan: Well people criticize Trump for a number of reasons. Not just his policies, but his perceived character and temperament and things like that. But what I think you saw in the election is that the American people said they didnt care about those things as much anymore.

(I): As long as his economic policy

Mr Jayabalan: Well, as long as he proves to be a good President. If he does what he says in terms of making America great again, however thats defined, theres something to that. And I think he knows, he really does think America is the richest, most powerful, freest, best country to live in, and he says, Were on the wrong track.Something like seventy percent of Americans think that Americas on the wrong track.

(I): Seventy percent? Wow.

Mr Jayabalan: Seventy percent. So I think thats the reason why Donald Trump is the President of the United States.

See the original post here:

Freedom and Liberty Through the Eyes of a Christian: - The Liberty Web English

Concord hosts West Liberty Thursday at Epling Stadium – Beckley Register-Herald

The start of high school baseball season is just around the corner, but college baseball is already here. Starting Thursday, the game will make its way to Linda K. Epling Stadium.

Concord will host West Liberty in a Mountain East Conference seven-inning doubleheader starting at noon.The Mountain Lions are off to a slow start after getting swept in a three-game series at UNC-Pembroke over the weekend.

They bring a bit of a southern West Virginia flair to the field. Junior pitcher Joey Lacek is a Liberty graduate, while brothers Ian and Austin Southcott are from Princeton. There is also a pair of James Monroe alumni in pitcher Reed McNeer and outfielder Connor Boothe. Outfielder Carter Shrewsbury was a senior on PikeViews 2016 Class AA state runner-up team.

That will usher in a full spring slate of baseball at the stadium.

Ohio Valley and Urbana will meet in a three-game series Feb. 23-24, followed by John Carroll University and Allegheny College in a three-game set Feb. 25-26.

Fairmont State and Lock Haven are penciled in for March 4-5.

After that, WVU Tech will make its annual run of games in Beckley. The Golden Bears who will make Epling Stadium their home turf in 2018 will host Alderson-Broaddus on March 15; River State Conference foe Indiana Southeast April 8-9; and Campbellsville April 14-15.

Annual Epling Stadium visitor Marshall will host a three-game Conference USA series against FIU April 21-23. Thundering Herd coach Jeff Waggoner was honored as the C-USA Coach of the Year in 2016.

Marshall is 19-20 all-time at Epling Stadium since it opened in 2010.

Finally, the MEC Tournament will return to Beckley May 11-14. The top three teams in each of the two divisions will qualify for the tournament.

Email: gfauber@register-herald.com and follow on Twitter @GaryFauber

View original post here:

Concord hosts West Liberty Thursday at Epling Stadium - Beckley Register-Herald

Regulators ease grip on Liberty Bell Bank – Cherry Hill Courier Post

American Traffic Solutions compiled a mashup of the top worst red light fails. USA TODAY NETWORK

Federal regulators have lifted orders affecting management of Liberty Bell Bank, which operates this office in Cherry Hill and two others.(Photo: Jim Walsh/Staff photographer)Buy Photo

EVESHAM - Liberty Bell Bank, citing progress in a turnaround effort, said Monday regulators have eased their grip on the company.

The Federal Deposit Insurance Corp. and state Department of Banking and Insurance have terminated consent orders in effect since November 2013, when Liberty Bell was struggling with persistent financial problems, the bank said.

Burlington Coat Factory faces storm over Ivanka

"The lifting of the consent orders is a testament to the progress we have made in strengthening our operations," said Benjamin F. Watts, the bank's president and CEO since November 2014.

The consent orders were needed for "safety and soundness issues" related to multiple problems at Liberty Bell, according to the state banking agency. Among other concerns, the orders cited the need to bolster the bank's management and capital, and to reduce "loan and lease losses."

Liberty Belllost $10.3 million for fiscal years 2012 through 2014.

Kingsway Learning Center eyes Voorhees

The three-office bank has reported profits for its last seven quarters, with a net income of $143,000 for 2015 and $134,000 for the first nine months of 2016.

It reported assets of $145 million at the end of its latest quarter.

A federal judge in October 2015 found some of Liberty Bell's losses were caused by "a fraudulent scheme" conducted by a business customer, Luis G. Rogers Sr.

In a civil suit, Liberty Bell alleged Rogers supplied phony contracts as collateral for loans to his equipment-leasing business, and that he then engaged in a check-kiting scheme when he could not pay back the loans.

Liberty Bell made more than 100 loans to Rogers' firm, LGR Group of Mount Holly, beginning in 2005. The bank ultimately realized Rogers was overdrawn by more than $3 million, the lawsuit said.

The bankbegan operations in 2003 with Cherry Hill attorney Michael Kwasnik as its principal founder. He resigned from the board three years later.

A state judge, ruling in a lawsuit brought by the Attorney General's Office, in October 2015 ordered Kwasnik and two other men to pay $8.6 million in restitution to victims of a Ponzi scheme from December 2008 through March 2010. That money was owed primarily to elderly investors who bought unregistered securities in another Cherry Hill firm, Liberty State Financial Holdings Corp.

Jim Walsh; (856) 486-2646; jwalsh@gannettnj.com

Read or Share this story: http://on.cpsj.com/2kEirJV

Read the rest here:

Regulators ease grip on Liberty Bell Bank - Cherry Hill Courier Post

Longtime Unity Party Steward Abandons UP For Liberty Party – Front Page Africa

Monrovia The exodus of key political figures from the ruling Unity Party is becoming a concern ahead of the crucial October elections.

Report by Henry Karmo - This email address is being protected from spambots. You need JavaScript enabled to view it.

I did not discuss with the president and I think our President is one of the most tolerant presidents and she understands that as a human I have a right to act when and where I want to, he said.

No, I did not discuss with the Vice president because he hasnt been in country; the option is to accept and for the record, there is no bad feelings between the VP and I.

"We are friends we can always talk; politics is not about antagonizing or attacking one another we will continue to be friends Harrison S. Karnwea

Businessman Musa Bilitys switch to opposition Liberty Party drew awe, and now Harrison Karnwea, another famous member of the ruling party, on Monday officially declared his membership for the Liberty Party.

Observers say its a boost for the opposition party as they look set to gain momentous support due to the influx of politicians and ordinary Liberians that are also pledging their support to the candidacy of Cllr. Charles Brumskine.

Recently, a group under the banner Professional, teachers and lecturers pledged its support to the party.

Mr. Karnwea, head of the Forestry Development Authority (FDA), has been a strong supporter of the ruling Unity Party for the past 12 years.

In an interview with FrontPageAfrica via telephone, he said his decision to join the Liberty Party has been long coming but he chose to keep it personal, describing his move as unconditional and only intended to build a very strong party.

Karnwea said: My brother, everyone wants to be where he will be appreciated. It is my right as a person to decide where I want to be and when I want to be. It is not about Unity Party and me, it is about Liberia and at this point I think I can be a good help to Liberia than UP.

Responding to question about his role as running mate to Cllr. Brumskine, he said: My coming over to the LP is unconditional my interest is to build a very strong party and whatever comes out of it so be it.

Asked whether he discussed his decision with President Ellen Johnson Sirleaf or his current standard bearer Vice President Joseph Boakai, he added that his decision was personal.

I did not discuss with the president and I think our President is one of the most tolerant presidents and she understands that as a human, I have a right to act when and where I want to, he said.

No I did not discuss with the Vice president because he hasnt been in country; the option is to accept and for the record, there is no bad feelings between the VP and I. We are friends we can always talk; politics is not about antagonizing or attacking one another we will continue to friends.

He continued: This is a decision that has been long coming I didnt just want to talk about it. I told you we will build on what UP have done. I am not going to be like people who left the UP and said the Party has not done much.

Gain for Unity Party?

Reacting to Karnweas exit from the party, Unity Party Chairman Wilmot Paye said the decision is welcoming and he described it as definite gain for the party.

That too many people want to be running mate at the same time. We welcome his exit its a good thing we are happy about that. We are growing a new generation of leaders and that new generation is what we are proud of, Paye said.

What I mean is that people who have their personal ambition that could not be seen in UP have to leave. You know what it means for somebody who is desperate about something and wanted to be and cannot be and you not ready to make them.

Dont forget, Karnwea wanted to be Chairman and he couldnt be, so obviously you can understand why and this thing has been coming for more than six months. It is surprising to you, not to us and by the way - he and Brumskine are business partners. I dont know why two of them working together will be strange to you.

Paye said UP never wanted Karnwea to leave the party while describing the former internal affairs minister as an individual who has benefited from the ruling establishment. He said the party expected loyalty in return.

The Liberian people want people who stand for principles, who when we say yes, we mean yes. People who whether rain or shine we are still there, who are not opportunistic and not chasing money. How many people can be running mate at the same time? We just dont have room for too many running mates, the UP Chairman said.

Continue reading here:

Longtime Unity Party Steward Abandons UP For Liberty Party - Front Page Africa

LETTER: Statue of Liberty has no place in debate over immigration – Sioux City Journal

In the Feb. 6 Mini Editorial, the writer sought to defend her opinion that all foreigners have an entitlement to enter the United States by referring to what is "inscribed on the Statue of Liberty." This is a much-too-common misconception.

There is nothing inscribed upon the Statue of Liberty; instead, I assume the writer was referring to Emma Lazarus' sonnet "The New Colossus." This is the sonnet that contains the oft-cited line "Give me your tired, your poor, your huddled masses ..." The poem is not "inscribed" on the Statue of Liberty. It is engraved on a bronze plaque which is mounted in the lower level inside the pedestal upon which the Statue stands.

The origin of the Statue of Liberty has nothing to do with immigration. It was a present from the people of France to commemorate our Declaration of Independence and was intended to be a symbol of liberty. I cannot see where the Statue of Liberty has any place in the immigration debate. - Robert B. Deck, Sioux City

Read this article:

LETTER: Statue of Liberty has no place in debate over immigration - Sioux City Journal

Former Libertarian presidential candidate visits alma mater – Standard Online

Former Libertarian presidential candidate and Missouri State alumus Austin Petersen was welcomed back to campus by the Missouri States Young Americans for Liberty on Thursday, Feb. 8.

According to the chapter president, sophomore history major Jaret Scharnhorst, Young Americans for Liberty is a nationwide organization that is focused on recruiting, training and educating students on the ideals of liberty and the Constitution.

Petersen opened his talk by throwing in a little humor as he talked about the ideals of the Libertarian Party.

Here is being a Libertarian in a nutshell, I just want gay married couples to be able to guard their marijuana fields with automatic rifles, Petersen said.

Petersen graduated from Missouri State in 2004, majoring in musical theatre. In 2016, Petersen ran for president of the United States with the Libertarian Party. He became the runner-up for the nomination to the governor of New Mexico, Gary Johnson.

After graduating from MSU, he moved to New York to become an actor where he noticed that the taxes were quite high. He said he noticed even with the little money that actors make, the government still took quite a bit out.

This is what sparked Petersens interest in politics. Before he knew it, he was working his way up the ladder in Washington D.C.

About a year later, he said he saw that his preferred candidate for the Republican Party, Rand Paul, was probably not going to make it through the primary. So, he decided to take matters into his own hands.

I thought to myself, If he did not make it to the primary, then there would not be someone who embodied my beliefs, Petersen said, So, I thought, Well Im turning 35 this year, (and) I am constitutionally eligible, so I decided to throw my hat into the ring.

In his speech, Petersen talked about Libertarian ideals and how they differ from those of Republicans and Democrats.

You know with this past election having two not very popular candidates, people are looking to third parties now more than ever, Petersen said.

Petersen also covered a wide array of controversial issues that surround this nation today, one of those being the War on Drugs.

One of the first things that I would do would be to abolish the War on Drugs completely, Petersen said. The reason drugs are dangerous is because they are illegal. Doing drugs is a victimless crime. So, yes, I do believe that heroin should be legal, that way we are able to study it. If we do that, Im sure that once people realize how bad it is for you, the usage of the drug will go way down.

Scharnhorst said he believes that bringing in Petersen will do great things for the organization

You know bringing in a person of Austins caliber is a really big deal, Scharnhorst said. If you tell people that you have a presidential candidate, and MSU alum come and speak, that will really get people to come out to hear his message and our message as well.

Justin Orf, senior political science major, was in the audience during Petersens speech, and had good things to say about Petersen.

I really liked his speech, because it provides us with different viewpoints, Orf said. College Republicans and Libertarians have similar views on less government, so it is pretty cool to see that connection. But it also shows us how Libertarians diverge a bit from normal conservatism.

As Petersen concluded his speech, he said the sole role of government should be to protect citizens liberties.

Read the original post:

Former Libertarian presidential candidate visits alma mater - Standard Online

The New Nasty Woman: We Will Miss the Old One – Being Libertarian

In the midst of what should have been (if not for the populist political revolts of 2016) the dawn of a Clinton presidency, I find it surreal I lament that the very woman I detest will not be leading the American nation for the next four to eight years.

There, I have said it. Mere months after her exit from the political arena, I most sincerely miss Hillary Clinton.

She was corrupt, uninspiring, and had been part of the political establishment for so long she became their most notorious poster child. Yet, for all her faults she successfully kept radical, progressive, democratic-socialism at bay in the 2016 elections.

She defeated Bernie Sanders, but another prodigy of the left is waiting in the wings. That looming figure, of course, is none other than Senator Elizabeth Warren. The very senator who recently found herself subject to Senate Majority Leader Mitch McConnells blundered attempt to silence her during debate on Senator Jeff Sessions confirmation as Attorney General. This monumental mistake on part of the Republican leadership has now only thrown her further into the liberal progressive spotlight that was already warming towards her.

The Democrats, particularly the partys most vocal and active progressive wing, are bitter and seething with contempt, and angered with their own party that took actions to suppress socialist Bernie Sanders during the primaries, and angered with the larger American electorate, who denied them the chance to coronate their queen um, I mean, elect the first female President.

With Warren, they have the chance to right both of these perceived wrongs cast upon them; if they are successful, the policies sure to be enacted by a Warren presidency would turn any foe of Clinton from the chant of Lock Her Up! to Im With Her!

Clinton supported increasing the federal minimum wage to $12, and luke-warmly supported local and state attempts to increase it to $15, while Senator Warren highlighted in 2013 that the minimum wage should be at $22+ if it were continually tied to the standard of living.

Clinton, a staunch supporter of entitlement spending, such as Social Security, was pragmatic enough to not completely rule out the possibilities of cuts or restructuring the system. By contrast, Warren is a hardliner who not only refuses to cut or restructure Social Security, but wishes to expand the program already operating under financial strain.

Clinton was reluctant to withdraw her support of trade deals like the Trans-Pacific Partnership, and once in office would likely have waffled on doing anything about stopping them, while Warren was a fierce advocate against them. This comes at a time when the Republican Party has become skeptical of trade under the leadership of President Donald Trump. Losing even more ground for pro-trade ideals could threaten our national economy, which even I, who am critical of multi-lateral trade deals, admit could be a problem, because a counterbalancing view always helps moderate extremes, in this case extremes of economic protectionism.

So while we all loved to hate her, Hillary Clinton may soon become a name we fondly look back upon. What strange times in which we find ourselves.

This post was written by Bric Butler.

The views expressed here belong to the author and do not necessarily reflect our views and opinions.

Like Loading...

Read the rest here:

The New Nasty Woman: We Will Miss the Old One - Being Libertarian

The world’s sexiest islands are in the middle of nowhere – New York Post

The Indian Oceans farflung islands have got us in the mood.

Situated in the worlds warmest ocean and surthressrounded hundreds of miles away by Africa, India and Asia, these utterly secluded, tropical destinations have managed to up their allure with a wave of new and renovated oh-so-romantic resorts.

Whether set in the jungle or mere feet behind pristine, winding white beaches and aquamarine waters, youll likely fall hard, whether youre with your partner, friends or family.

Two new hotelsoffer waterfront Zen in quiet pockets of Turks...

Upping the overwater-bungalow ante is Soneva Jani, which opened this fall on one of the Noonu Atolls many coral islands some 700 miles southwest of Sri Lanka (but far closer to its 20-year-old sister Maldivian retreat, Soneva Fushi). Each of Janis 25 one- to four-bedroom accommodations which, attached by boardwalks, seem to curl over the crystal-clear waters of a nearly 3-square-mile lagoon have a private pool, several with slides that drop you right into the water, and roofs that open for romantic evenings of stargazing. Should you want a closer look at the night sky, try out the observatory. During the day, you can snorkel, swim, go boating, visit the spa and let the staff set you up on a castaway picnic (from $1,870).

Shangri-La Hotels and Resorts

Shangri-La Hotels and Resorts

Shangri-La Hotels and Resorts

Shangri-La Hotels and Resorts

Shangri-La Hotels and Resorts

Shangri-La Hotels and Resorts

Two new hotelsoffer waterfront Zen in quiet pockets of Turks...

Shangri-Las $30 million renovation of Le Touessrok Resort & Spa on this island nation, located nearly 600 miles east of Madagascar, has 200 beachside water-view rooms and suites plus three beach villas. But the biggest draw for those seeking some sexy fun in the sun might be the private island offshore, reserved exclusively for hotel guests, who are waited on by at-your-service beach butlers. Hong Kong-based Shangri-La added some enticingly Asian elements to the hotel, which has boasted an amour-minded French clientele since first opening in 1978. The eight new restaurants and bars include gourmet Japanese and Indian flavors, and the spa tempts with four couples treatment rooms two with their own outdoor shower and tub, perfect for a post-massage relaxation a deux (from $330).

Two new hotelsoffer waterfront Zen in quiet pockets of Turks...

Known for its wellness-minded retreats, Six Senses opened a private-island resort a few months back on the fifth-largest isle in this archipelago, 1,100 miles east of Kenya. The 30 one- and two-bedroom villas of Six Senses Zil Pasyon sit between three white sand beaches on the 650-acre Flicit Island. Each has its own pool, but the 120-foot-long waterfront pool, separated from the sea only by a rock wall, is an even more alluring draw as is the 7,000-square-foot spa, which, appropriately enough, opens on Valentines Day. Its five open-air treatment pavilions, waterfalls and elevated saltwater pool will nestle amid rocky outcroppings and lush plantings (from about $1,720).

Tucked between Indias Bay of Bengal and Southeast Asias Andaman Sea (part of the Indian Ocean), Jalakara is an intimate boutique resort. Its on the gorgeous Havelock Island, said to be one of the best diving spots in South Asia.

The six new suites and one cottage on this former plantation property which sits amid a rainforest on a hill that has views to the sea and is a 20-minute walk to the water offer large windows and doors that open to the jungle. Spare but stylish interiors showcase the best of handcrafted local woodwork and block-printed textiles, and owner and chef Marko Hill oversees the food, whichspans both West and East.

If youre looking to unplug, Jalakara is it Hill decided to just say no to Wi-Fi and the Internet, so youll indulge instead in low-key activities like playing board games, visiting the spa or snorkeling at one of its nearby beaches (from $195).

Read the original post:

The world's sexiest islands are in the middle of nowhere - New York Post

Japan Protests Russian Move To Give Some Disputed Islands Names – RadioFreeEurope/RadioLiberty

Japanese officials said they lodged a protest with Russia over Moscow's decision to give names to five formerly unnamed islands of a disputed chain known as the Southern Kuriles in Russia.

"This is unacceptable and runs counter to Japan's position," Yoshihide Suga, the secretary-general of Tokyo's cabinet told a news conference on February 14, referring to what Japan calls the Northern Territories. "We sent a note of protest to Russia through diplomatic channels."

Russian Prime Minister Dmitry Medvedev last week gave names to five islands.

The TASS news agency reported that the names commemorate General Kuzma Derevyanko, who signed an act on Japan's capitulation at the end of World War II in 1945, General Alexei Gnechko, who commanded the Kurile Islands Landing operation in 1945, Soviet diplomat Andrei Gromyko who was foreign minister of the Soviet Union from 1957 through to 1985, Sakhalin regional Governor Igor Farkhutdinov, and Anna Shchetinina, the world's first female captain of an ocean-going merchant ship.

Soviet troops seized the island chain in 1945 after Japan surrendered at the end of WWII. The territorial spat has prevented the two countries from concluding a post-war peace treaty.

Japan has sought to resolve the dispute in recent talks with Russia. Suga said the incident will not affect those talks.

Go here to see the original:

Japan Protests Russian Move To Give Some Disputed Islands Names - RadioFreeEurope/RadioLiberty

Isles of Love: The 8 Most Romantic Islands Available by Cruise – TravelPulse

PHOTO: The island of Santorini at twilight. (photo via Flickr/Maggie Meng)

Trending Now

St. Lucia

The Pitons, St. Lucia's twin peaks, jut above the surface of the sea creating one of the most beautiful islands on the Caribbean. The beauty of the island as your ship approaches it is the number one reason to include it on a romantic cruise. The black sand beaches of Anse Chastanet is another. The snorkeling and scuba diving are a fabulous way to share the island with your loved one. Look at Royal Caribbean's Serenade of the Seas itinerary in the Southern Caribbean that includes St. Lucia. Serenade is a medium-sized ship from the Brilliance Class, making it one of the most romantic ships of the line.

St. Kitts

With only 67 square miles of land, St. Kitts is a small sliver of paradise to share with your partner. Opt for a scooter rental to get you to the beaches that line the narrow strip of land leading to the south end of the island for some of the best snorkeling to be found in the Caribbean.Princess gets you there in romantic style on ships sailing from Florida to the Eastern Caribbean.

St. Maarten

If the butterflies that keep the hills of St. Maarten alive with color are not romantic enough, consider sailing on Celebrity's Equinox when it overnights on the island. Overnighting in port gives you enough time to really experience the island. Imagine arriving in time for a beautiful sunset, before setting out to explore an evening of French cuisine on the French side of the island. Then spend the next day enjoying the fun and sun of the Dutch side before your ship sails for the next port.

READ MORE 6 Reasons to Consider a Clothing Optional Cruise

Santorini

The beauty of Santorini may very well be one of the most romantic backdrops on the planet. Santorini wedding photos and proposals abound, but even if wedding bells aren't in your future, a cruise stop at the Greek caldera in the sea is perfect for romantic beach breaks or hiking the Fira to Oia trail.

Pro tip: When you shop for Santorini cruises check the calendars at CruiseTimetables.com to avoid cruises that are in port with a host of large ships. The island can get quite congested, so you need all the help you can get.

Consider Silverseas Silver Muse, which carries only 596 passengers. When it calls on Santorini in July, it will be only one of two ships currently scheduled to be there, that the other ship is the Star Flyer clipper ship carrying only 170 passengers.

Tahiti

Everything about a cruise to Tahiti sounds romantic, doesn't it? Paul Gauguin Cruises makes it more so. With overnight stays and inspirational excursions, there is more than enough romance to enjoy.

The Galapagos

My former editor, Jo Piazza, fell in met and love with her husband on a cruise in the Galapagos, so communing with the natural wonders of the Galapagos must be romantic. Cruises here range from very small boats with no air conditioning to luxury lines like Silverseas' Silver Galapagos, which sails the islands year-round.

Cuba

The romance of Havana is all about its mystique. Consider a cruise that includes an overnight stay to fully explore the city. Look at NCL's Norwegian Sky, which now offers free unlimited bar drinks.

Venice

Italy's "City of Love" is actually a cluster of man-made islands. Top pics for a romantic stop here include the obvious gondola ride, walks along the Grand Canal, or sunsets in St. Mark's Square.

Viking Ocean Cruises sails to and from the port of Venice, some with overnights in port to allow you to fully appreciate the romance of the island city.

You may use your Facebook account to add a comment, subject to Facebook's Terms of Service and Privacy Policy. Your Facebook information, including your name, photo & any other personal data you make public on Facebook will appear with your comment, and may be used on TravelPulse.com. Click here to learn more.

View original post here:

Isles of Love: The 8 Most Romantic Islands Available by Cruise - TravelPulse

Islands Fish Grill hosts Suzy’s Secret Supper – Florida Today

Buy Photo

Suzy's Secret Supper(Photo: FLORIDA TODAY File)

The next Suzy's Secret Supper has been set for March 7, and I hope you can join me for a fabulous meal at Islands Fish Grill in Indialantic.

Islands is known for its super fresh seafood. Peek into the kitchen, and chances are you'll findchef Jared Moretti with a filet knife in hand and a whole,just-caught grouper on the counter in front of him.

Suzys Secret Supper begins at 6 p.m. March 7. Join mefor a five-course dinner, plus an amuse bouche. Meet chefs Nate Saint Denis and Jared Moretti, make new friends, and enjoy the bounty of the Atlantic. I've told you the time and place, but the menu and the guest list are our secret!

Islands chefs take fish to new level

Cost of the supper is $95, which includes meal, wine pairings, tax and tip.Not a wine drinker? No problem, you can opt out of the wine pairing. The cost will be $77, which includes meal, tax and tip. To keep the experience intimate, only a limited number of tickets will be sold.

Tickets are available at floridatoday.com/insider. FLORIDA TODAY subscribers can log into the site to get a code for a $10 discount.

Islands Fish Grill is at 111 Fifth Ave, Indialantic, across the street from the Atlantic Ocean.

Email Leonard at sleonard@floridatoday.com.

Read or Share this story: http://on.flatoday.com/2kDqRRM

See original here:

Islands Fish Grill hosts Suzy's Secret Supper - Florida Today

Coachella 2017’s local shows (formerly known as Localchella) include Future Islands, Little Dragon and more – Time Out Los Angeles (blog)

The best alternative to Coachella? Ironically, it comes fromthe music festival's own promoter. Each spring Goldenvoice plucks some of the sub-headliner acts into two weeks ofclub and theater shows across L.A., and a few a bit beyond.

At this year's local Coachella showsaffectionately known as Localchella, officially and boringly billed as"Goldenvoice Presents April"Future Islands, Nicolas Jaar, Ryksopp, New Order,Floating Points, Local Natives, Little Dragon, Jamie xx, Empire of the Sun, the Avalanches and more have all been tapped for local shows. And by local, we mean everywhere from Pappy & Harriet's to the Santa Barbara Bowl, with spots like the Roxy and the Regent in between.

Tickets are already on salefor a couple of shows, but there are three major on-sale dates to keep in mind: February 17, February 24 and March 3. You'll find the corresponding on-sale dates below.

As in past years, some shows are being promoted under theFYFPresents bannerlest you forget that Goldenvoice's hometown fest has moved up to July this year.

In the meantime, here's the full list of shows in a much more searchable format for your pleasure.

Chicano Batman The Roxy

Denzel Curry The Glass House (Pomona)

The Head and the Heart Arlington Theatre (Santa Barbara)

Banks + Jack Garratt Fox Theater (Pomona)

Sampha El Rey Theatre

Crystal Castles The Glass House (Pomona)

Francis & the Lights El Rey Theatre

Bishop Briggs El Rey Theatre

Future Islands The Roxy

The Head and the Heart Pappy & Harriet's

Joseph Constellation Room (Santa Ana)

Little Dragon Pappy & Harriet's

Oh Wonder The Glass House (Pomona)

SOHN Fonda Theatre

Two Door Cinema Club Fox Theater (Pomona CA)

What So Not The Novo

Young Turks in Palm Springs With Ben UFO, Four Tet, Francis & the Lights, Jamie xx, Kamaiyah, Sampha, PNL Palm Springs Air Museum (Palm Springs)

Two Door Cinema Club + Grouplove Santa Barbara Bowl (Santa Barbara CA)

Banks & Steelz El Rey Theatre

Bonobo The Theatre at Ace Hotel

Car Seat Headrest The Regent

Kaytranada Fox Theater (Pomona)

King Gizzard & the Lizard Wizard The Roxy

Mura Masa The Glass House (Pomona)

Nicolas Jaar Pappy & Harriet's

Blossoms The Echo

Bonobo The Glass House (Pomona)

Breakbot The Roxy

DJ Shadow Fonda Theatre

Galantis The Novo

Glass Animals Fox Theater (Pomona)

Hinds The Regent

Little Dragon The Observatory (Santa Ana)

Mura Masa El Rey Theatre

New Order Santa Barbara Bowl (Santa Barbara)

The Avalanches Fonda Theatre

Bastille The Novo

Empire of the Sun Shrine Expo Hall

Future Islands The Glass House (Pomona)

Glass Animals Pappy & Harriet's

Hinds The Observatory (Santa Ana)

Jack Garratt The Roxy

Local Natives Fox Theater (Pomona)

SURVIVE El Rey Theatre

Tacocat Constellation Room (Santa Ana)

Car Seat Headrest Pappy & Harriet's

Future Islands Pappy & Harriet's

Lil Uzi Vert The Observatory (Santa Ana)

Mitski The Glass House (Pomona)

Moderat The Mayan

Pond The Echo

Roisin Murphy Fonda Theatre

Ryksopp The Novo

Swet Shop Boyz The Echoplex

Whitney El Rey Theatre

Daphni Lot 613

Floating Points (Live) El Rey Theatre

Honne The Roxy

Jai Wolf The Glass House

Roisin Murphy Fonda Theatre

Glass Animals + Little Dragon + Jagwar Ma Santa Barbara Bowl

Guided By Voices The Roxy

Whitney The Glass House

Phantogram The Glass House

Chicano Batman The Glass House (Pomona)

Want more? Sign up here to stay in the know.

Michael oversees the Things to Do section along with comedy coverage as associate editor at Time Out Los Angeles. He has a soft spot for deli sandwiches and Disneyland. Follow him on Twitter at @mjuliano.

Here is the original post:

Coachella 2017's local shows (formerly known as Localchella) include Future Islands, Little Dragon and more - Time Out Los Angeles (blog)

Black Lives Matter Leader: White People are ‘Sub-Human,’ ‘Genetic Defects’ – Mediaite

The co-founder of the Toronto chapter of the Black Lives Matter protest movement has come under scrutiny in recent days for an old Facebook post that declared white people were genetically inferior to their black peers.

Whiteness is not humxness, wroteYusra Khogali,in a now-deleted post (using gender-neutral alternative spelling). In fact, white skin is sub-humxn. All phenotypes exist within the black family and white [people] are a genetic defect of blackness.

Khogali proceeded to go on an extended pseudoscientific rant about the benefits of dark skin, according to The Toronto Sun. Melanin enables black skin to capture light and hold it in its memory mode which reveals that blackness converts light into knowledge, she claims at one point. Melanin directly communicates with cosmic energy.

White [people] are recessive genetic defects. This is factual, she claimed, nonfactually.

Khogali made the Facebook post months ago, but her comments resurfaced after she declared Canadian Prime MinisterJustin Trudeaua white supremacist terrorist, earning her criticism from liberal allies.

[image via screengrab]

>>Follow Alex Griswold (@HashtagGriswold) on Twitter

Have a tip we should know? tips@mediaite.com

Continued here:

Black Lives Matter Leader: White People are 'Sub-Human,' 'Genetic Defects' - Mediaite

Progression of HIV triggered by each patient’s genes – Genetic Literacy Project

Scientists have long observed important differences in the rate of disease progression among individuals infected with HIV. It is now well established that the disease progresses faster in people with a higher viral load the amount of genetic material from the virus found in their blood.

[This study]is the first to investigate the relative impacts of human and viral genetics on viral load, within one group of patients.

[The researchers]found that genetic differences between HIV strains accounted for 29% of the contrasts in viral load between patients. Human genetic variation on the other hand, explains 8.4%. Together, human and viral genetics explained a third of viral load variation.

These findings suggest that the patients genetics trigger genetic mutations in the HIV virus as it multiplies inside them, thus influencing the clinical course of HIV infection.

Our study improves our understanding of HIV pathogenesis. This is an important step the better you know your enemy, the more equipped you are to fight it and fight against the disease, said [Jacques Fellay, director of the study bycole Polytechnique Fdrale de Lausanne in Switzerland.]

[The study can be found here.]

The GLP aggregated and excerpted this blog/article to reflect the diversity of news, opinion, and analysis. Read full, original post:Patients and virus genetics account for a third of HIV viral load

Continued here:

Progression of HIV triggered by each patient's genes - Genetic Literacy Project

The Surprisingly Early Settlement of the Tibetan Plateau – Scientific American

Genetic analysis suggests that humans have continuously inhabited the Tibetan Plateau as far back as the last ice age.

The first humans who ventured onto the Tibetan Plateau, often called the roof of the world, faced one of the most brutal environments our species has ever confronted. At an average elevation of more than 4,500 meters, it is a cold and arid place with half the oxygen present at sea level. Although scientists had long thought no one set foot on the plateau until 15,000 years ago, new genetic and archaeological data indicate that this event may have taken place much earlierpossibly as far back as 62,000 years ago, in the middle of the last ice age. A better understanding of the history of migration and population growth in the region could help unravel the mysteries of Tibetans' origin and offer clues as to how humans have adapted to low-oxygen conditions at high altitudes.

As reported in a recent study in the American Journal of Human Genetics, researchers got a better grasp of the plateau's settlement history by sequencing the entire genomes of 38 ethnic Tibetans and comparing the results with the genomic sequences of other ethnic groups. It has revealed a complex patchwork of prehistoric migration, says Shuhua Xu, a population geneticist at the Chinese Academy of Sciences' Shanghai Institutes for Biological Sciences. A big surprise was the antiquity of Tibetan-specific DNA sequences, Xu says. They can be traced back to ancestors 62,000 to 38,000 years ago, possibly representing the earliest colonization of the plateau.

As an ice age tightened its grip after that first migration, genetic mixing between Tibetans and non-Tibetans ground to a halt for tens of thousands of yearssuggesting that movement into Tibet dropped to a minimum. The migration routes were probably cut off by ice sheets, Xu says. It was simply too harsh even for the toughest hunter-gatherers. But about 15,000 to 9,000 years agoafter the so-called last glacial maximum (LGM), when the ice age was at its harshest and Earth's ice cover had reached its peakthousands flocked to Tibet en masse. It's the most significant wave of migration that shaped the modern Tibetan gene pool, Xu says. This meshes well with several independent lines of evidence showing that Tibetans began to acquire genetic mutations that protected them from hypoxia 12,800 to 8,000 years ago.

Xu's team was the first to sequence the entire Tibetan genome, and the resolution is really impressive, says archaeologist Mark Aldenderfer of the University of California, Merced, who was not involved in the research. The study, he adds, provides fine details of how different populations from various directions may have combined their genes to ultimately create the people that we call Tibetans. It shows that 94 percent of the present-day Tibetan genetic makeup came from modern humanspossibly those who ventured into Tibet in the second wave of migrationand the rest came from extinct hominins. The modern part of the Tibetan genome reflects a mixed genetic heritage, sharing 82 percent similarity with East Asians, 11 percent with Central Asians and 6 percent with South Asians.

In addition, Xu's team identified a Tibetan-specific DNA segment that is highly homologous to the genome of the Ust'-lshim Man (modern humans living in Siberia 45,000 years ago) and several extinct human species, including Neandertals, Denisovans and unknown groups. The segment contains eight genes, one of which is known to be crucial for high-altitude adaptation. Xu suspects that a hybrid of all these species may have been the common ancestor of the pre-LGM population on the plateau.

The study also reveals a startling genetic continuity since the plateau was first colonized. This suggests that Tibet has always been populatedeven during the toughest times as far as climate was concerned, Xu says. That idea contradicts the commonly held notion that early plateau dwellers would have been eliminated during harsh climate intervals, including the LGM, says David Zhang, a geographer at the University of Hong Kong, who was not involved in Xu's work. Aldenderfer and others contend that parts of the plateau could have provided a refuge for people to survive the ice age. There were plenty of places for [those early populations] to live where local conditions weren't that bad, such as the big river valleys on the plateau, he says.

Also supporting the antiquity of the peopling of Tibet is a study presented at the 33rd International Geographical Congress last summer in Beijing, where a team unveiled the plateau's earliest archaeological evidence of human presencedating to 39,000 to 31,000 years ago. The site, rich with stone tools and animal remains, lies on the bank of the Salween River in the southeastern Tibetan Plateau.

Different lines of evidence are now converging to point to much earlier and much more persistent human occupation of the plateau than previously thought, Aldenderfer says. But he notes that pieces are still missing from the puzzle: More excavations are required to close those gaps.

Here is the original post:

The Surprisingly Early Settlement of the Tibetan Plateau - Scientific American

Designers take a holistic approach to health-care spaces – SFGate

In this undated photo provided by CCRM New York, sunlight streams in to a serene, calming waiting space overlooking midtown New York's bustling cityscape, at the Colorado Center for Reproductive Medicine's New York offices. (CCRM New York via AP) less In this undated photo provided by CCRM New York, sunlight streams in to a serene, calming waiting space overlooking midtown New York's bustling cityscape, at the Colorado Center for Reproductive Medicine's New ... more Photo: AP In this undated photo provided by Perkins+Will, a fantastic flower blooms overhead in the dining area at Nemours children's hospital in Orlando, with a design theme centered on creating a hospital in a garden. (Jonathan Hillyer Photography/Perkins+Will via AP) less In this undated photo provided by Perkins+Will, a fantastic flower blooms overhead in the dining area at Nemours children's hospital in Orlando, with a design theme centered on creating a hospital in a garden. ... more Photo: Jonathan Hillyer Photography, AP

This undated photo provided by Perkns+Will shows the Lytle Center at Swedish First Hill Medical Center in Seattle, where a cozy fireplace welcomes visitors. (Eckert and Eckert Photography/Perkins+Will via AP)

This undated photo provided by Perkns+Will shows the Lytle Center at Swedish First Hill Medical Center in Seattle, where a cozy fireplace welcomes visitors. (Eckert and Eckert Photography/Perkins+Will via AP)

Designers take a holistic approach to health-care spaces

Health-care facilities can be stressful places for patients and visitors, with depressing waiting rooms, rows of uncomfortable seating, a blaring television. But designers of some medical spaces are remedying the situation.

A more holistic approach includes mood-elevating colors and artwork. Chairs are angled to look out the window. Screens offer calming nature scenes instead of newsfeeds. There's softer overhead lighting and skylights. Sometimes, diffusers even waft a gentle breeze of lavender or citrus to mask the harsh scents of disinfectants and medicines.

Sheila Semrou, a Milwaukee-based design consultant who has worked on numerous health-care facilities, says she takes inspiration from local scenery and geography. Think big windows, natural light and a palette that reflects outside vistas.

"The results can be supportive spaces that nurture occupants and provide comfort," she says.

New research is showing that a lot of clinical design norms are hard on patients, she says. Bright, polished floors can be slippery, and create glare. Bland color schemes aren't so much soothing as uninspiring.

"Studies suggest that some of the best environments for health and healing incorporate a variety of hues, use both warm and cool tones, and vary color saturation," Semrou says.

At the Diane L. Max Health Center in New York City, a project by Stephen Yablon Architecture, upbeat primary and neon colors were used on midcentury-style seating, facades and to define different areas of the building.

On the other hand, in the reception area of Memorial Sloan Kettering in West Harrison, New York, blonde terrazzo floors, rift white oak and chic, light blue chairs clad in walnut veneer create a serene space, designed by EwingCole.

In colder climes, a fireplace can add a welcoming feel at little cost, says Carolyn BaRoss, who leads a health-care interior design division at the New York firm Perkins and Will.

"A number of our projects in Canada and the northwestern U.S. have included fireplaces as part of the waiting areas and other lounges," she says. "We try to specify ones that look the most realistic and surround them with interesting materials. We've used both electric and gas fireplaces. They provide a source of warmth, but are fitted with a protective enclosure for safety."

BaRoss says an Orlando, Florida, project, Nemours Children's Hospital, has a "hospital in a garden" theme, with nature elements, daylight and views woven into the design. There are small "picnic blanket" designs in the flooring pattern, and child-size play areas, as well as "ceiling elements like the large flower in the dining area."

Treatment areas are also benefiting from this kind of patient-focused design. The Florida Hospital for Children in Orlando and the Women and Children's Hospital in Adelaide, Australia, are among facilities offering the "Philips' Ambient Experience" in MRI suites. Patients select a lighting color, as well as audiovisual projections like nature scenes, to help ease anxiety during the procedures.

At Mercy St. John's Hospital in St. Louis, an enormous vibrant butterfly greets visitors in the lobby, while patient floors are decorated with laser-cut images of animals.

BaRoss says new LED technology allows for more dimmable, flattering lighting, which can also be used to help patients find their way in a new facility.

At the Colorado Center for Reproductive Medicine in New York City, designed by Perkins and Will, chairs face out onto the cityscape. Look out the window, and you'll also see Robert Indiana's large "Hope" sculpture on the street below.

"The waiting room is typically where a patient will spend the most time. With that in mind, we took care to design an environment that's low-stress and soothing," says Dr. Brian Levine, the practice's director.

"We took advantage of the views by placing our waiting room in the brightest and most visually stimulating aspect of our floor plan. We chose light-colored wall coverings, flooring, and furniture to help reflect and carry the light throughout the room, so no patient would ever feel like they're in a 'dark corner,'" he says.

Melissa Thompson, a health-care industry strategist from Westport, Connecticut, developed breast cancer shortly after giving birth to her daughter in 2015, and began a long treatment journey. The experience got her thinking about how important physical environment was to her comfort and, she believes, even her recovery.

She didn't stay long at the first hospital she went to: "It smelled bad like an old cafeteria full of chemicals."

But Greenwich Hospital in Connecticut and Memorial Sloan Kettering in New York City were a different story. Rooms were oases of natural woods and light. Both hospitals had lounge areas where patients could relax outside of their rooms in a warm, comfortable atmosphere.

"I was noticeably happier, and discharged sooner," she says.

See more here:

Designers take a holistic approach to health-care spaces - SFGate

ConsejoSano raises $4.9M for Spanish-language healthcare services platform – MobiHealthNews

San Francisco-based ConsejoSano, which makes a health services navigation platform for Spanish speakers in America, has raised $4.9 million in Series A funding in a round led by 7wire Ventures. Tufts Health Ventures, TOTAL Impact Capital, Wanxiang Healthcare Investments, Acumen, Oxeon Partners and Impact Engine also contributed, bringing the companys total funding to date at $7.2 million.

The company, whose name means HealthyAdvice in Spanish, mainly works with health plans, employers and at-risk providers who are trying to increase engagement from their Spanish-speaking customers, employees and patients. ConsejoSanos integrated platform arms clients with multi-channel messaging, care navigation, data analytics and 24/7 access to native Spanish-speaking medical navigators. The latest funding will be used to develop more sophisticated data collection and analytics that will be parlayed into preventive care.While many healthcare and technology companies offer Spanish-language options,like Anthem BlueCross's Spanish telemedicineand messaging capabilities, most function as add-ons to the more comprehensive services offered mainly in English. That's where ConsejoSano wants to set itself apart.

America is bilingual, but healthcare isnt, ConsejoSano on its website, referencing the 54 million Hispanic people in the country, of whom 73 percent prefer to speak Spanish. Working off the fact that mobile phone penetration among the Hispanic population is significant 92 percent own a cellphone, according to a 2015 Research Center survey ConsejoSano offers secure, two-way text messaging so users can reach out directly to their target population with timely, customized information and behavior change programs.

"The extraordinary interest we have received from clients seeking to better serve their Spanish speaking employees, insured customers, and patients has clearly demonstrated the need for ConsejoSano's unique services," ConsejoSano Founder and CEO Abner Mason said in a statement. "Over 40 million people in the United States prefer or need to speak in Spanish about healthcare issues, and we're committed to helping clients and partners to provide the care and support they deserve."

ConsejoSano was founded in 2014, and it was selected as a preferred vendor by global consultancy firm Mercer last year. Among their first clients were LaSalle Medical Associates, a large Southern California provider that primarily serves a Medicaid population, and labor union health plan Unite Here Health, which serves restaurant and hotel workers. The company also has an Industry Advisory Council of healthcare professionals with a mission to reduce healthcare disparities for Hispanics across the country.

Todays health care system can often be complex, and almost impossible to navigate for those who speak a primary language other than English, Derek Abruzzese, managing director of Tufts Health Ventures and chief strategy officer of Tufts Health Plan, said in a statement. ConsejoSano performs a very important service for its clients, simplifying the complicated health care world for Spanish speaking individuals. This investment is in line with our mission of improving the health and wellness of the diverse communities we serve.

See the rest here:

ConsejoSano raises $4.9M for Spanish-language healthcare services platform - MobiHealthNews

Annual Lake Nona Impact Forum tackles future of US health care – Orlando Sentinel

The annual Lake Nona Impact Forum takes place this weekatMedical City, bringing together several U.S. Surgeons General, health-care executives, policy experts and public figures like Dr. Deepak Chopra.

Officials will also announce new health and well-being initiatives for the Lake Nona community.

Now in its fifth year, the Impact Forum was inspired by other well-known forums for thought leaders such as the Aspen Institute.

What makes the conference unique is its local role.

The meeting aims to familiarizethe world with Lake Nona Medical City, and presentLake Nona as a living lab fortesting ideas and creating potential partnerships, said Gloria Caulfield, executive director of the Impact Forum.

Most folks who come to Impact Forum say they had no idea that theres this vibrant life-science center here, she said.We want to tell people and business leaders that this community cares about promoting Orlando as a destination for companies that to bring high-paying jobs in life-science, technology, health and wellness.

Achieving thisgoal may be a bit tricky and even more important this year, because right across the street from where the conference is being held, sits Sanford Burnham Prebys Medical Discovery Institute. Central Floridas only nonprofit research institute was one of the Impact Forums hosts last year, but is now planning to leave Florida.

This year, the forum is held in a walking distance from Sanford Burnham at GuideWell Innovation Center, UCF College of Medicine and UF Research & Academic Center.

The choice of meeting location wasnt so much because of changes at Sanford Burnham, butbecause of new opportunities that have presented themselves since last year, including the opening of the GuideWell Innovation buildinglast March, said Caulfield, vice president of strategic alliance at Tavistock.

Sign up for the weekly Health Report newsletter

The 3-day invitation-only conferenceaims to have a more direct call to action message for its guest, particularly because itstakingplace during a year when the U.S. health-care system is at its most volatile.

Weve never had an interesting time like this, with a new administration and lot of questions and uncertainty regarding health care, said Caulfield. So this is the time to remind this audience that its not about the status quo and that innovation is crucial to the path forward.

In addition to health-care and policy leaders, the conference is also hosting executives from industry giants like Google and LinkedIn.

Its always been a goal for us to have more of those prominent guests to help re-imagine what they would do with technology weve invested in here, said Caulfield.

Since last years Impact Forum, Lake Nona has introduced a healthy smart home named WHIT, and has opened the doors to GuideWell Innovation CoRE, a co-working space for health startups.

Both grew from ideas brought up during one of the conferences, Caulfield said.

The Impact Forum kicks off on Wednesday evening, with remarks by UCF College of Medicine dean Dr. Deborah German, City of Orlando Mayor Buddy Dyer and Orange County Mayor Teresa Jacobs. It wraps up on Friday with a discussion about the future of public health by a panel of former U.S. Surgeons General Dr. David Satcher, Dr. Antonia Novello, Dr. Richard Carmona and Dr. Jocelyn Elders. CNNs Sanjay Gupta will moderate the panel.

The public isnt completely excluded from the conference.

Certain sessions will be live-streamed on Impact ForumsFacebook page. Videos from other sessions will be available at a later date onthe forumswebsite.

Also, Chopra will lead a free meditation session for Lake Nona residents on Thursday evening.

Johnson & Johnson is the conferences main sponsor.

nmiller@orlandosentinel.com, 407-420-5158,@naseemmiller

Visit the Vital Signs health blog

More local health news headlines

Read the original here:

Annual Lake Nona Impact Forum tackles future of US health care - Orlando Sentinel

Diabetes in your DNA? Scientists zero in on the genetic signature of risk – Medical Xpress

February 13, 2017 A depiction of the double helical structure of DNA. Its four coding units (A, T, C, G) are color-coded in pink, orange, purple and yellow. Credit: NHGRI

Why do some people get Type 2 diabetes, while others who live the same lifestyle never do?

For decades, scientists have tried to solve this mystery - and have found more than 80 tiny DNA differences that seem to raise the risk of the disease in some people, or protect others from the damagingly high levels of blood sugar that are its hallmark.

But no one "Type 2 diabetes signature" has emerged from this search.

Now, a team of scientists has reported a discovery that might explain how multiple genetic flaws can lead to the same disease.

They've identified something that some of those diabetes-linked genetic defects have in common: they seem to change the way certain cells in the pancreas "read" their genes.

The discovery could eventually help lead to more personalized treatments for diabetes. But for now, it's the first demonstration that many Type 2 diabetes-linked DNA changes have to do with the same DNA-reading molecule. Called Regulatory Factor X, or RFX, it's a master regulator for a number of genes.

The team reporting the findings in a new paper in the Proceedings of the National Academy of Sciences comes from the University of Michigan, National Institutes of Health, Jackson Laboratory for Genomic Medicine, University of North Carolina, and the University of Southern California.

They report that many diabetes-linked DNA changes affect the ability of RFX to bind to specific locations in the genomes of pancreas cell clusters called islets. And that in turn changes the cells' ability to carry out important functions.

Islets contain the cells that make hormones, including insulin and glucagon, which keep blood sugar balanced in healthy people. In people with diabetes, that regulation goes awry - leading to a range of health problems that can develop over many years.

"We have found that many of the subtle DNA spelling differences that increase risk of Type 2 diabetes appear to disrupt a common regulatory grammar in islet cells," says Stephen C.J. Parker, Ph.D., an assistant professor of computational medicine and bioinformatics, and of human genetics, at the U-M Medical School. "RFX is probably unable to read the misspelled words, and this disruption of regulatory grammar plays a significant role in the genetic risk of Type 2 diabetes."

Parker is one of four co-senior authors on the paper, which also includes Michael Boehnke, Ph.D., of the U-M School of Public Health's Department of Biostatistics, Francis Collins, M.D., Ph.D., director of the National Institutes of Health, and Michael L. Stitzel, Ph.D. of the Jackson Laboratory.

Prior to their current faculty positions Parker and Stitzel worked in Collins' lab at the National Human Genome Research Institute. Parker's graduate student, Arushi Varshney, is one of the paper's co-first authors with Laura Scott, Ph.D., and Ryan Welch, Ph.D., of the U-M School of Public Health's Department of Biostatistics and Michael Erdos, Ph.D., of the National Human Genome Research Institute.

They performed an extensive examination of DNA from islet samples isolated from 112 people. They characterized differences not just in DNA sequences, but also in the way DNA was packaged and modified by epigenetic factors, and the levels of gene expression products that indicated how often the genes had been read and transcribed.

This allowed them to track the "footprints" that RFX and other transcription factors leave on packaged DNA after they have done their job.

RFX and other factors don't bind directly to the part of a gene that encodes a protein that does a cellular job. Rather, they bind to a stretch of DNA near the gene - a runway of sorts.

But when genetic changes linked to Type 2 diabetes are present, that runway gets disrupted, and RFX can't bind as it should.

Each DNA change might alter this binding in a different way, leading to a slightly different effect on Type 2 diabetes risk or blood sugar regulation. But the common factor for many of these changes was its effect on the area where RFX is predicted to bind, in the cells of pancreatic islets.

So, says Parker, this shows how the genome - the actual sequence of DNAcan influence the epigenome, or the factors that influence gene expression.

The researchers note that a deadly form of diabetes seen in a handful of babies born each year may be related to RFX mutations. That condition, called Mitchell-Riley syndrome, involves neonatal diabetes and malformed pancreas, and is known to be caused by a rare autosomal recessive mutation of one form of RFX.

Explore further: Unique mapping of methylome in insulin-producing islets

More information: Genetic regulatory signatures underlying islet gene expression and type 2 diabetes, PNAS, http://www.pnas.org/cgi/doi/10.1073/pnas.1621192114

Throughout our lives, our genes are affected by the way we live. Diet, exercise, age and diseases create imprints that are stored in something called methylome. Now, for the first time, researchers at the Lund University ...

Variations in non-coding sections of the genome might be important contributors to type 2 diabetes risk, according to a new study.

Problems with insulin secretion experienced by people with Type 2 diabetes, parallel similar problems with insulin-secreting beta cells in many individuals with Down syndrome. A new study, published on May 19 in PLOS Genetics ...

Personalized treatment for people with diabetes could be a step closer after researchers discovered how a single gene mutation fundamentally alters pancreatic development.

Doctors have long known that men with low testosterone are at greater risk for developing type 2 diabetes. For the first time, researchers have identified how testosterone helps men regulate blood sugar by triggering key ...

Researchers at Wake Forest Baptist Medical Center's Institute for Regenerative Medicine and colleagues have discovered a new protein that may play a critical role in how the human body regulates blood sugar levels. Reporting ...

Why do some people get Type 2 diabetes, while others who live the same lifestyle never do?

It is now possible to reprogram cells from the liver into the precursor cells that give rise to the pancreas by altering the activity of a single gene. A team of researchers at the Max Delbrck Center for Molecular Medicine ...

Keeping blood sugar levels within a safe range is key to managing both type 1 and type 2 diabetes. In a new finding that could lead to fewer complications for diabetes patients, Yale School of Medicine researchers have found ...

Latino children who live in areas with higher levels of air pollution have a heightened risk of developing Type 2 diabetes, according to a new USC-led study.

Bladder dysfunction is a reality for about half of patients with diabetes and now scientists have evidence that an immune system receptor that's more typically activated by bacteria is a major contributor.

Rat-grown mouse pancreases help reverse diabetes in mice, say researchers at Stanford, University of Tokyo

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Read this article:

Diabetes in your DNA? Scientists zero in on the genetic signature of risk - Medical Xpress