Republican Health Care Proposal Would Cover Fewer Low-Income Families – NPR

Rep. William "Bill" Huizenga, R-Mich., says House Republicans "know the direction we want to go and sort of the destination" with replacing Obamacare. Andrew Harrer/Bloomberg via Getty Images hide caption

Rep. William "Bill" Huizenga, R-Mich., says House Republicans "know the direction we want to go and sort of the destination" with replacing Obamacare.

House Republicans are debating a plan to replace the Affordable Care Act that would give consumers tax credits to buy insurance, cut back on Medicaid and allow people to save their own money to pay for health care costs.

The outline plan is likely to take away some of the financial help low-income families get through Obamacare subsidies, and also result in fewer people being covered under the Medicaid health care program for the poor.

"In general this is going to result in fewer people covered nationwide," says Caroline Pearson, a senior vice president at Avalere, a health care consulting group.

Republican leaders distributed the skeleton proposal at a meeting of the House Republican Conference in the Capitol on Thursday. Lawmakers now have an outline to bring with them to their districts for the Presidents Day holiday weekend, where they may face constituents with questions about what is going to happen to their health care. The plan is based on one outlined last summer by House Speaker Paul Ryan.

Rep. Bill Huizenga, R-Mich., called the 18-page outline "guideposts and a road map."

"We know the direction we want to go and sort of the destination," Huizenga said outside the meeting.

Lawmakers who attended the meeting said the plan is to repeal the Affordable Care Act with a bill similar to one that passed in 2015 but was vetoed by then-President Barack Obama. That proposal would have repealed all the taxes and subsidies associated with the health care law and would have killed the mandate for individuals to buy health insurance by getting rid of the tax penalty used to enforce it.

This Congress could either first pass a repeal bill and then a replacement bill, or include replacement elements in the repeal.

The meeting Thursday centered on "principles and goals on where we're going in patient-centered care," said House Ways and Means Committee Chairman Kevin Brady, R-La., after the meeting.

"We're talking about repealing, replacing and starting to return control of health care and restoring the free market," he said.

Most of the plan is silent on how much money lawmakers want to put behind their proposals, so it's impossible to know exactly how generous the plan is and how many people it would cover.

The elements of the plan include replacing the subsidies that help people buy insurance through Obamacare exchanges with fixed tax credits to buy coverage on the open market.

The major difference between the two is that the Obamacare subsidies increase as premiums rise so that consumers are responsible for the same premium amount, which is tied to their income. The tax credits proposed by Ryan are not tied to income but rise as a person ages and insurance rates increase.

"The important thing on the tax credits is that they're not income adjusted and we don't know how big they are," Pearson says.

She says it's unlikely they'll be as generous as the Obamacare subsidies.

"This likely means that low-income people will have difficulty affording individual insurance," she says.

The outline distributed by Republicans repeatedly mentions that people will be able to buy so-called catastrophic coverage, which has limited day-to-day benefits but protects people when they have a serious illness or accident that requires a lot of health care.

The plan also calls for expanding health savings accounts, which allow people to save their own money tax-free to pay for health care costs. It calls for the limits on HSA savings to rise from $6,750 per family to $13,100.

HSAs are a favorite among conservatives because they encourage people to save and plan for their health spending and to shop around for price.

Democrats have criticized the focus on HSAs because they only help people who have extra money to put away and give a bigger tax cut to people with higher incomes.

The Republicans' plan also calls for a major restructuring of the Medicaid health care program for the poor. It would repeal the Medicaid expansion that most states adopted under the Affordable Care Act, which allowed able-bodied people with incomes just above the poverty line to become eligible for Medicaid coverage.

And it would cap how much the federal government spends per person per year. Right now, Medicaid pays all health care costs for those who are eligible.

"This is a potentially significant incentive for states to get serious about efficiency," says Paul Howard, director of health policy at the Manhattan Institute, a conservative think tank.

Howard says states currently have an incentive to increase their spending on Medicaid, because it boosts the amount of federal money they get.

Ryan's plan would make Medicaid either a block grant program, where states receive a fixed amount of money, or it would be a per capita benefit, where the federal government would give the states a set amount for each beneficiary.

States could still offer Medicaid to those who became eligible under expansion, but the states' share of the costs would be higher than it is under the Affordable Care Act, likely making it too expensive for many states to do so.

Finally, the Republican plan would offer states pools of cash to come up with ways to expand insurance access to more people.

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Republican Health Care Proposal Would Cover Fewer Low-Income Families - NPR

Nebraska Medicine CEO talks about the future of health care – Omaha World-Herald

Americans today can shop for a new TV by spending an hour online pulling up ads to compare prices and reading reviews to compare features and performance.

Dr. Daniel DeBehnke, the chief executive officer of Nebraska Medicine, said Thursday that those same Americans, driven by rising health care costs and market changes that have left them paying a greater share of their health care costs, are beginning to shop for elective health care services such as colonoscopies and knee replacements with the same eye toward value and quality.

To give them more of that data, Nebraska Medicine this summer plans to launch a star-based online rating system for its physicians that will incorporate patient ratings and reviews. Services such as Healthgrades and Yelp already provide some ratings, but many are based on a limited number of reviews.

DeBehnke, speaking at a forum on the future of health care at the Omaha Press Club, said health care providers need to focus on such changes or disruptions in the market, including new technologies and care delivery models, rather than becoming distracted by events in Washington, including debate about the repeal or replacement of the Affordable Care Act.

The disrupters are forming the market around us, he said. Until we change the system so it provides value to the consumer ... were going to miss the boat.

DeBehnke, who took over Nebraska Medicines top post in July, said other industries have missed disruptions in their own sectors. Blockbuster continued to compare itself with other brick-and-mortar movie retailers while online streaming services such as Netflix were on the rise.

The fact that the United States spends 16 percent of its GDP on health care and still doesnt have the best life expectancies helped drive the creation of the health care law. While it has flaws and needs tweaks, DeBehnke said, it has achieved its goal of increasing the number of people with insurance coverage.

At this point, he said, repealing the law without replacing it would be socially and politically untenable. I would go out on a limb and say it wont happen, he said.

Meantime, he said, some provisions of the law have resulted in shifting a greater share of costs to consumers. Some 39 percent of plans on the exchanges had deductibles of $6,000 or more. Thats spurred a need for greater data transparency. Shopping services such as Castlight and Healthcare Bluebook allow consumers to shop online for services and prices.

Virtual care services and retail clinics, from kiosks in stores to the Minute Clinics inside CVS drugstores, are providing consultations and minor medical care, he said. Walmart has even rolled out primary care clinics in some states.

One concern for health care providers about such outlets is fragmentation of patient information. A patients regular primary care doctor wouldnt necessarily know that a patient had received a new prescription. Common electronic medical records systems and data-sharing agreements may offer opportunities to partner with such services.

DeBehnke said Nebraska Medicine also is beginning to explore online appointment booking for its patients. DeBehnke previously served as CEO of Medical College Physicians, a group of about 1,500 practitioners in the Milwaukee area. That system rolled out a similar online appointment system.

julie.anderson@owh.com; 402-444-1066

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Nebraska Medicine CEO talks about the future of health care - Omaha World-Herald

Molina Healthcare stock dives on ‘clearly unacceptable’ earnings – Los Angeles Times

Molina Healthcare Inc. shares plunged Thursday, the day after the Long Beach insurer said losses related to its participation in the Affordable Care Act marketplace ledto clearly unacceptable earnings for 2016.

The stock dived $10.71, or 17.9%, to $49.18.

The insurer reported after the close of regular trading Wednesday that its adjusted earnings per diluted share fell to 50 cents last year, down from $2.57 the year before. The results were disappointing: Analysts surveyed by FactSet had expected earnings of $2.78 a share.Income before income taxes fell to $137 million last year from $322 million the year before.

Molina Healthcare said in a statement that the decreasewas primarily the result of the declining profitability of our Marketplace program.

Molina Healthcare covers about 600,000 ACA enrollees in nine states. Speaking during a Wednesday afternoon conference call with analysts, Chief Accounting Officer Joseph White singled out Texas as a state where the insurer was doing relatively well on the marketplace He said the insurer was hanging in there in Florida and California.

Molina Healthcare has been traditionally known as a Medicaid provider, and its HMO plans are often the low-cost option in ACA plan categories.

The company might soon end its participation in the marketplaces created by the Affordable Care Act, also known as Obamacare.It believes there are simply too many unknowns with the Marketplace programto commit to participation beyond 2017,J. Mario Molina, president and chief executive of Molina Healthcare, said in Wednesdays call with analysts.

We will wait and see how the new administration and Congress will adjust the program, and we plan to evaluate our participation on a state-by-state basis, Molina said.

Thecompanys 2016 results are clearly unacceptable, he said, butoutside of the Marketplace issues, 2016 was, in many respects, a successful year.

Revenue was $17.7 billion close to analysts expectations of $17.8 billion, and up from $14.1 billion the year before.

samantha.masunaga@latimes.com

Twitter:@smasunaga

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UPDATES:

2:45 p.m.: This article was updated with the stocks closing price.

11 a.m.: This article was updated with a more recent stock priceand more information about Molina Healthcares performance in individual state marketplaces.

This article was originally published at 9:30 a.m.

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Molina Healthcare stock dives on 'clearly unacceptable' earnings - Los Angeles Times

NAB to create new digital platform for healthcare – ZDNet

The National Australia Bank (NAB) has announced it is working with health-tech startup Medipass Solutions to develop a new digital platform to connect patients with healthcare practitioners.

Although the "Uber-like" platform is currently in testing and development phase, NAB expects it will allow users to also receive upfront cost estimates, make appointments, and take care of payment or claiming for the consultation. It will also leverage the NAB-owned health claims and payments system (HICAPS).

NAB executive general manager NAB Labs Jonathan Davey said the bank has been working closely with Medibank and a small number of practitioners since late last year to test the platform, with a full market launch slated for mid-2017.

"We will shortly broaden testing to further practitioners and we will work with more health insurers to bring to fruition the full benefits this service can offer," Davey said.

For the initiative, NAB has also partnered with Melbourne-based tech startup Localz which won NAB Labs' inaugural Hackathon in December 2014, and received funding from NAB Ventures.

"NAB and Medipass Solutions are redefining the healthcare experience, delivering an 'Uber-like' approach to the way patients, practitioners, and health funds integrate," Davey added.

"The solution delivers a seamless and transparent experience for patients, practitioners, and health insurers, through a digitally integrated platform; the first of its kind globally with such breadth and capability."

The platform is being developed initially for Allied Health Practitioners who provide Healthcare services to patients with private health insurance cover, NAB said.

Last year, NAB chief executive Andrew Thorburn said the bank was looking to make faster, bigger, better changes, and to do that, it needed to embrace the hunger found within fintech companies.

"I actually think we are a fintech company ourselves. I think we have the mindset of a fintech company, and I actually think we have a lot of the assets of a fintech company," he said previously.

"Fintech companies -- the smaller, emerging ones -- they're hungry, they want to make an impact, they find an opportunity, and they go after it. And that's the sort of hunger we need inside our own company.

"They should be respected, but not feared."

NAB updated its internet banking app in November, with the bank touting the platform as not just an app, rather a "complete experience"; one that is sitting on top of a new digital backbone.

NAB then began the rollout of its application programming interface (API) developer portal in December, which will eventually see the public availability of selected NAB APIs to third-party developers.

Last year, NAB experienced three system outages in the space of seven days.

The first hit its internet banking, customer call centres, and payments processing as a result of a "number of system outages" experienced the night before.

The bank's customers Australia-wide were then prevented from using their bank cards in ATMs or at EFTPOS terminals, with the outage also affecting NAB merchant terminals and the HICAPS system.

The third outage meant customers were unable to access their internet banking.

The bank also reported a 94.4 percent statutory profit slump to AU$352 million for the 2016 financial year, citing technology investments as a main contributing factor.

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NAB to create new digital platform for healthcare - ZDNet

Long Beach-based Molina Healthcare’s stock tumbles after poor earnings report – Long Beach Press Telegram

Long Beach-based health insurance giant Molina Healthcare watched its stock price tumble Thursday, dropping $10.71 to $49.18, setting off alarms in the wake of Wednesdays deeply disappointing revenue report.

The company reported an $8 million profit for the 2016 calendar year on Wednesday, down from $143 million in 2015. Officials blamed the fall on rules within the Affordable Care Act that seek to create an even-playing field in the insurance market.

Molina Healthcares total revenue last year topped $17.7 billion, but its risk transfer payments a complex system that seeks to provide parity to insurers who must take patients, regardless of their health needs added up to $325 million more than what the company projected when setting its 2016 pricing levels.

Molina said in a call on Wednesday with investors that the government needs to change the rules, which fueled its revenue losses. The company alleged the government collected millions of dollars more than it should have.

Molina officials say they filed a lawsuit in January seeking to recover roughly $52 million in risk corridors payments made in 2015. Molina also alleges that the government owes it $90 million in payments made last year.

Molina was not alone on a rugged Thursday on Wall Street. Avon Products, a direct seller of cosmetics, also plunged after reporting weaker-than-expected results. The company said the number of sales representatives, who are famous for selling its products door to door, slipped from a year earlier. The stock dropped $1.09, or 18.6 percent, to $4.77.

The days largest loss within the S&P 500 came from TripAdvisor, which fell $5.78, or 11 percent, to $46.92 after reporting weaker revenue and earnings for its latest quarter than analysts forecast.

The news came as stock markets around the world took a breather Thursday, breaking up a torrid run thanks to an improving economy, stronger corporate earnings and hopes for more business-friendly policies from Washington.

The Standard & Poors 500 index dipped Thursday to break a seven-day winning streak, its longest in three and a half years, though it remains a nudge away from its record high.

The dollars value also dipped against rival currencies, and Treasury yields fell as bond prices rose.

The S&P 500 fell 2.03 points, or 0.1 percent, to 2,347.22. The Dow Jones industrial average rose 7.91 points, less than 0.1 percent, to set another record at 20,619.77. The Nasdaq composite dipped 4.54 points, or 0.1 percent, to 5,814.90. Four stocks fell for every three that rose on the New York Stock Exchange.

Analysts said it wasnt surprising to see stocks take a break following their long run higher.

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The market has reacted quite strongly to the Trump reflation trade, deregulation and lower-tax comments over the last couple weeks, said Nate Thooft, senior portfolio manager at Manulife Asset Management. And on top of that weve had a pretty darn good earnings season. It just needs a little bit of a breather today.

He said he still sees stocks as better investments than bonds.

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Long Beach-based Molina Healthcare's stock tumbles after poor earnings report - Long Beach Press Telegram

Stepping up the hunt for genetic diseases – Medical Xpress

February 16, 2017 Credit: UNIGE

When a child is conceived, he or she receives DNA from both parents. The child's own genome thus consists of a maternal and a paternal genome. However, some genesabout 100 out of the 20,000 encoded genes are exclusively expressed either from the maternal or from the paternal genome, with the other copy of the gene remaining silent. We know that these imprinted genes are more likely to lead to serious genetic diseases, such as PraderWilli or Angelman syndrome. Researchers at the University of Geneva (UNIGE), Switzerland, have devised a new technique, based on a combination of biology and bioinformatics, to quickly and accurately detect the imprinted genes expressed in each of the cell types that constitute the human organs. This major breakthrough will improve our understanding and diagnosis of genetic diseases. The study can be read in full in the American Journal of Human Genetics.

The research team, led by Professor Stylianos Antonarakis from the Department of Genetic Medicine and Development in the Faculty of Medicine at UNIGE, focused on genomic imprinting. This is a set of genes exclusively expressed from the genetic code inherited either from the father (the paternal allele) or from the mother (maternal allele). Why is there so much interest in the identification of the imprinted genes? Because if a deleterious mutation affects the functional allele, it cannot be compensated by the expression of the second silent allele, likely causing a serious genetic disease. The goal, therefore, is to determine the imprinted genes in all cell types of human body tissues that are liable to cause these kind of diseases.

Until recently, millions of cells were analysed together without distinction. "We have now developed a new technique with a better resolution, known as Human Single-Cell Allele-Specific Gene Expression," explains Christelle Borel, UNIGE researcher. "The process can be used to simultaneously examine the expression of the two alleles, paternal and maternal, of all known genes in each individual cell. The method is fast and can be carried out on thousands of single cells with the utmost precision using next-generation sequencing technology." The heterogeneity of each tissue of the body is thus analysed in detail while searching for imprinted genes in disease-relevant tissue. The individual's genome is sequenced, as is the genome of both parents, in order to identify the parental origin of the alleles transcribed in the person's single cell.

Each cell is unique

Federico Santoni, first author of the study and researcher at UNIGE and HUG (Geneva University Hospitals) further explains, "We establish the profile of the allelic expression for thousands of genes in each single cell. We then process this data with a novel computational and statistical framework to identify the specific signature of each imprinted gene, enabling us to accurately record them." This new technique redefines the landscape of imprinted genes by examining all cell types, and can be applied to all tissues affected by diseases, such as cardiac and brain tissue. Moreover, the scientists have discovered novel imprinted genes and demonstrated that some were restricted to certain tissues or cell types.

This technique focuses on the specific characteristics of each individual by treating each cell as a single entity. This concept, called Single-cell Genomics, is part of an emerging field that is assuming an all-important role at UNIGE, which sees it as the future of medicine that will be personalised rather than generalised. Thanks to the technique pioneered by UNIGE researchers, it will be possible to identify new disease causing genes and to adapt a specific and targeted treatment for individual patients.

Explore further: Expanding the brain: Research identifies more than 40 new imprinted genes

More information: Federico A. Santoni et al. Detection of Imprinted Genes by Single-Cell Allele-Specific Gene Expression, The American Journal of Human Genetics (2017). DOI: 10.1016/j.ajhg.2017.01.028

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Stepping up the hunt for genetic diseases - Medical Xpress

Personalized medicine may do more to treat rather than prevent chronic diseases – Medical Xpress

February 16, 2017 by Sharon Horesh Bergquist, The Conversation What could genomic medicine do in the future? Credit: http://www.shutterstock.com

Personalized medicine, which involves tailoring health care to each person's unique genetic makeup, has the potential to transform how we diagnose, prevent and treat disease. After all, no two people are alike. Mapping a person's unique susceptibility to disease and targeting the right treatment has deservedly been welcomed as a new power to heal.

The human genome, a complete set of human DNA, was identified and mapped a decade ago. But genomic science remains in its infancy. According to Francis Collins, the director of the National Institutes of Health, "It is fair to say that the Human Genome Project has not yet directly affected the health care of most individuals."

It's not that there haven't been tremendous breakthroughs. It's just that the gap between science and its ability to benefit most patients remains wide. This is mainly because we don't yet fully understand the complex pathways involved in common chronic diseases.

I am part of a research team that has taken on the ambitious goal of narrowing this gap. New technologies are allowing us to probe DNA, RNA, proteins and gut bacteria in a way that will change our understanding of health and disease. Our hope is to discover novel biological markers that can be used to diagnose and treat common chronic conditions, including Alzheimer's disease, heart disease, diabetes and cancer.

But when it comes to preventing the leading causes of death which include chronic diseases, genomics and precision medicine may not do as much as we hope.

Many diseases aren't due only to genetics

Chronic diseases are only partially heritable. This means that the genes you inherit from your parents aren't entirely responsible for your risk of getting most chronic diseases.

The estimated heritability of heart disease is about 50 percent. It's 64 percent for Type 2 diabetes mellitus, and 58 percent for Alzheimer's disease. Our environment and lifestyle choice are also major factors; they can change or influence how the information coded in our genes is translated.

Chronic diseases are also "complex." Rather than being controlled by a few genes that are easy to find, they are weakly influenced by hundreds if not thousands of genes, the majority of which still elude scientists. Unlocking the infinite combinations in which these genes interact with each other and with the environment is a daunting task that will take decades, if ever, to achieve.

While unraveling the genomic complexity of chronic disease is important, it shouldn't detract from existing simple solutions. Many of our deadliest chronic diseases are preventable. For instance, among U.S. adults, more than 90 percent of Type 2 diabetes, 80 percent of coronary arterial disease, 70 percent of stroke and 70 percent of colon cancer are potentially avoidable.

Smoking, weight gain, lack of exercise, poor diet and alcohol consumption are all risk factors for these conditions. Based on their profound impact on gene expression, or how instructions within a gene are manifested, addressing these factors will likely remain fundamental in preventing these illnesses.

Will more knowledge be more power?

A major premise behind personalized medicine is that empowering patients and doctors with more knowledge will lead to better decision-making. With some major advances, this has indeed been the case. For instance, variants in genes that control an enzyme that metabolizes drugs can identify individuals who metabolize some drugs too rapidly (not giving them a chance to work), or too slowly (leading to toxicity). This can lead to changes in medication dosing.

When applied to prevention, however, identifying our susceptibility at an earlier stage has not aided in avoiding chronic diseases. Research challenges the assumption that we will use genetic markers to change our behavior. More knowledge may nudge intent, but that doesn't translate to motivating changes to our lifestyle.

A recent review found that even when people knew their personal genetic risk of disease, they were no more likely to quit smoking, change their diet or exercise. "Expectations that communicating DNA-based risk estimates changes behavior is not supported by existing evidence," the authors conclude.

Increased knowledge may even have the unintended consequence of shifting the focus to personal responsibility while detracting from our joint responsibility for improving public health. Reducing the prevalence of chronic diseases will require changing the political, social and economic environment within which we make choices as well as individual effort.

What about treating chronic diseases?

Perhaps the most awaited hope of the genomic era is that we will be able to develop targeted treatments based on detailed molecular profiling. The implication is that we will be able to subdivide disease into new classifications. Rather than viewing Type 2 diabetes as one disease, for example, we may discover many unique subtypes of diabetes.

This already is happening with some cancers. Patients with melanoma, leukemia or metastatic lung, breast or brain cancers can, in some cases, be offered a "molecular diagnosis" to tailor their treatment and improve their chance of survival.

We have been able to make progress in cancer therapy and drug safety and efficacy because specific gene mutations control a person's response to these treatments. But for complex, chronic diseases, relatively few personalized targeted treatments exist.

Customizing treatments based on our uniqueness will be a breakthrough, but it also poses a challenge: Without the ability to test targeted treatments on large populations, it will make it infinitely harder to discover and predict their response.

The very reason we group people with the same signs and symptoms into diagnoses is to help predict the average response to treatment. There may be a time when we have one-person trials that custom tailor treatment. However, the anticipation is that the timeline to getting to such trials will be long, the failure rate high and the cost exorbitant.

Research that takes genetic risk of diabetes into account has found greater benefit in targeting prevention efforts to all people with obesity rather than targeting efforts based on genetic risk.

We also have to consider decades of research on chronic diseases that suggest there are inherent limitations to preventing the global prevalence of these diseases with genomic solutions. For most of us, personalized medicine will likely complement rather than replace "one-size-fits-all" medicine.

Where does that leave us? Despite the inherent limitations to the ability of genomic medicine to transform health care, medicine in the future should unquestionably aspire to be "personal." Genomics and molecular biosciences will need to be used holistically in the context of a person's health, beliefs and attitudes to fulfill their power to greatly enhance medicine.

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Personalized medicine may do more to treat rather than prevent chronic diseases - Medical Xpress

Boehringer Ingelheim and Weill Cornell Medicine announce new … – Yahoo Finance

INGELHEIM, Germany--(BUSINESS WIRE)--

Boehringer Ingelheim today announced a collaboration with Weill Cornell Medicine to identify new treatment approaches for chronic obstructive pulmonary disease (COPD) in order to develop novel treatments that could possibly halt or even reverse the progression of the disease process. The new, three-year collaboration combines Weill Cornell Medicines Department of Genetic Medicines unique understanding of chronic airway diseases and experience in the investigation of novel therapeutic concepts for airway repair with Boehringer Ingelheims expertise in the discovery and development of new therapies for respiratory diseases. This collaboration is the second collaboration between Boehringer Ingelheim and Weill Cornell Medicine, following prior work in inflammatory bowel disease (IBD).

Chronic lower respiratory diseases, which include COPD, are the third leading cause of death in the United States, and approximately 15 million Americans have been told by a healthcare provider that they have COPD. It cannot be cured and current treatment approaches focus on bronchodilation, reducing symptoms and preventing exacerbations to decelerate the downward spiral of the disease. The goal is to help patients keep as active as possible and overall, improve their quality of life.

Our continuous search for molecular drivers of chronic obstructive airway diseases has revealed novel repair mechanisms that warrant further investigation of their potential as therapeutic approaches, said Dr. Ronald G. Crystal, Chairman of Genetic Medicine at Weill Cornell Medicine and lead investigator in the new collaboration. We will look to further expand our knowledge about progressive airway destruction in close collaboration with Boehringer Ingelheim and focus on promising therapeutic concepts with the potential to slow down or halt progressive airway damage in patients with COPD.

We are delighted to work with Dr. Crystal at Weill Cornell Medicine, who is one of the leading scientists in severe progressive airway diseases worldwide, said Dr. Clive R. Wood, Senior Corporate Vice President, Discovery Research at Boehringer Ingelheim. The scientists at Weill Cornell Medicine and Boehringer Ingelheim will work hand in hand to translate new discoveries into drug discovery and development programs at Boehringer Ingelheim. The new collaboration is an excellent example of our unique partnering approach and our focus on early innovation, underscoring our ambition to develop the next generation of medical treatments for patients with COPD.

Boehringer Ingelheim is combining a focus on cutting-edge science with a long-term view enabling the company to create a stable environment for the development of the next generation of medical breakthroughs. This new project adds another building block in this long-term strategy to improve the lives of patients with high unmet medical needs.

Weill Cornell's Office of BioPharma Alliances and Research Collaborations negotiated the three-year collaboration.The offices mission is to proactively generate, structure and market translational research alliances with industry in order to advance promising research projects that have commercial potential. For more information, contact Larry Schlossman at las2041@med.cornell.edu or at 212-746-6909.

For references and notes to editors, please visit:

http://www.boehringer-ingelheim.com/press-release/weill-cornell-collaboration-develop-next-generation-copd-treatments

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Boehringer Ingelheim and Weill Cornell Medicine announce new ... - Yahoo Finance

Bringing back the woolly mammoth – Patheos (blog)

From Hannah Devlin, Woolly mammoth on the verge of resurrection, scientists say | Science | The Guardian:

The woolly mammoth vanished from the Earth 4,000 years ago, but now scientists say they are on the brink of resurrecting the ancient beast in a revised form, through an ambitious feat of genetic engineering.

Speaking ahead of the American Association for the Advancement of Science (AAAS) annual meeting in Boston this week, the scientist leading the de-extinction effort said the Harvard team is just two years away from creating a hybrid embryo, in which mammoth traits would be programmed into an Asian elephant.

Our aim is to produce a hybrid elephant-mammoth embryo, said Prof George Church. Actually, it would be more like an elephant with a number of mammoth traits. Were not there yet, but it could happen in a couple of years.

The creature, sometimes referred to as a mammophant, would be partly elephant, but with features such as small ears, subcutaneous fat, long shaggy hair and cold-adapted blood. The mammoth genes for these traits are spliced into the elephant DNA using the powerful gene-editing tool, Crispr.

Until now, the team have stopped at the cell stage, but are now moving towards creating embryos although, they said that it would be many years before any serious attempt at producing a living creature.

Illustration by Flying Puffin (Mammut Uploaded by FunkMonk) [CC BY-SA 2.0 (http://creativecommons.org/licenses/by-sa/2.0)], via Wikimedia Commons

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Bringing back the woolly mammoth - Patheos (blog)

Gene Therapy for Rheumatoid Arthritis gets Approval to Start Clinical Trials – Labiotech.eu (blog)

Arthrogen will start a Phase Ib trial for a gene therapy aiming to treat rheumatoid arthritis with a single injection and reduce costs for patients.

Arthrogen,based in Amsterdam, is developing local gene therapies for inflammatory diseases. The biotech company has now announced it has received approval to start a Phase Ib trial with its lead candidate, ART-I02, in patients with rheumatoid arthritis who still suffer from inflamed joints despitemultiple treatments.

The clinical trial will be conducted by the Centre for Human Drug Research (CHDR) in Leiden, with collaboration from other University Medical Centers in the Netherlands. Patients will start to be recruited in the first quarter of this year and results are expected by the end of 2018.

ART-I02 consists of a recombinant adeno-associatedviral vector (rAAV) genetically engineered to encode the human interferon (hIFN-) protein, which has anti-inflammatory activity.By including an inflammation-inducible promoter in the genetic construct, the gene is only expressed when the patient suffers flares of acute pain and inflammation.

Founded in 2005 as a joint venture between the Dubai Bone & Joint Center (DBAJ) in the United Arab Emirates and the Academic Medical Center (AMC) in Amsterdam, Arthrogen has managed to raise almost 15M so far to support its pipeline for inflammatory disease.

One of the advantages of ART-I02 is that its delivered locallyin the rheumatic joint, only affecting the target area to minimize side effects. In addition, gene therapy offers a long-lasting treatment with a single injection, which can significantly reduce costs for patients in the long term. However, Arthrogen will have to be careful to not follow the steps of its neighboruniQure, whose firstcommercial gene therapy was a failure because of pricing issues.

Rheumatoid arthritis is a big market, expected to generate 32.5B ($34.6B) by 2020. The space is crowded, but by then blockbusters like top-seller Humira will no longer be protected by patents in both the US and Europe, leading the way for biosimilars and other options affordable in the long term such as gene therapy.

Images byMidas Anim; Tefi /Shutterstock

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Gene Therapy for Rheumatoid Arthritis gets Approval to Start Clinical Trials - Labiotech.eu (blog)

Gene Therapy Treatment Offered to Cancer Patients Saves Lives – TrendinTech

Cancer is a nasty disease that affects millions of people throughout the world. With as many as one on every two people being diagnosed with some form of cancer during their lives, its imperative that effective treatments are found to try and help those in need. While researchers and scientists work around the clock trying to put an end to the disease, sadly, there is still no cure. However, one new trial involving gene therapy treatment may bring a new wave hope to cancer patients and has already proved to be successful.

This new form of treatment works by removing cancer-fighting cells from the tumor, multiplying them by billions in the lab, and then popping them back into the patients body ready to attack the disease. One patient who has benefited greatly from this treatment is 51-year old Celine Ryan. She has diagnosed with stage 4 colon cancer over three years ago, and despite radiation, chemotherapy, and surgery, cancer had spread to her lungs and was threatening her life considerably. It was partly due to Ryans abnormal genetic makeup that researchers could work out how to attack the mutation thats the cause of many cancers.

In March 2015 Ryan was accepted onto the gene therapy trial and after spending a month in the hospital, letting the treatment do its thing, six out of the seven tumors she had disappeared. The treatment does not work for everyone, but every time its tried is another opportunity to learn something new. Dr. Steven Rosenberg is a leading researcher in immunotherapy at the National Cancer Institute in Bethesda, Maryland and heads the gene therapy trail. He says, Many have not responded. But from every patient that we treat, whether their cancers go away or not; we learn something. But, the treatment worked for Ryan, and she is now celebrating ten months of being cancer free. Moving forward, Rosenberg explains, We can do, and are planning to do, that kind of gene therapy using the exact receptor we got from Celines cells to treat other people.

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Gene Therapy Treatment Offered to Cancer Patients Saves Lives - TrendinTech

New AI Can Write and Rewrite Its Own Code to Increase Its Intelligence – Futurism

Learning From Less Data

The old adage that practice makes perfect applies to machines as well,as many of todays artificially intelligent devices rely on repetition to learn. Deep-learning algorithmsare designed to allow AI devices to glean knowledgefrom datasets and then apply what theyve learned to concrete situations. For example, an AI system is fed data about how the sky is usually blue, which allows it to later recognize the sky in a series of images.

Complex work can be accomplished using this method, but itcertainly leaves something to be desired. For instance, could the same results be obtained by exposing deep-learning AI to fewer examples? Boston-based startup Gamalondeveloped a new technology to try to answer just that, and this week, it released two products that utilize its new approach.

Gamalon calls the technique it employed Bayesian program synthesis. It is based on a mathematical framework named after 18th century mathematician Thomas Bayes. The Bayesian probability is used to refine predictions about the world using experience. This form of probabilistic programming a code that uses probabilities instead of specific variables requires fewer examples to make a determination, such as, for example, that the sky is blue with patches of white clouds. The program also refines its knowledge as further examples are provided, and its code can be rewritten to tweak the probabilities.

While this new approach to programming still has difficult challenges to overcome, it has significant potential to automate the development of machine-learning algorithms. Probabilistic programming will make machine learning much easier for researchers and practitioners, explained Brendan Lake, an NYU research fellow who worked on a probabilistic programming technique in 2015. It has the potential to take care of the difficult [programming] parts automatically.

Gamalon CEO and cofounder Ben Vigoda showed MIT Technology Review a demo drawing app that uses their new method. The app is similar to one released by Google last year in that it predicts what a person is trying to sketch. However, unlike Googles version, which relied on sketches it had previously seen to make predictions, Gamalons app relies on probabilistic programming to identify an objects key features. Therefore, even if you draw a figure thats different from what the app has previously seen, as long as it recognizes certain features like how a square with a triangle on top is probably a house it will make a correct prediction.

The two products Gamalon released show that this technique could have near-term commercial use. One product, the Gamalon Structure, using Bayesian program synthesis to recognize concepts from raw text, and it does so more efficiently than whats normally possible. For example, after only receiving a manufacturers description of a television, it can determine its brand, product name, screen resolution, size, and other features. Another app, called Gamalon Match, categorizes products and prices in a stores inventory. In both cases, the system can be trained quickly to recognize variations in acronyms or abbreviations.

Vigoda believes there are other possible applications, as well. For example, if equipped with a Beysian model of machine learning, smartphones or laptops wouldnt need to share personal data with large companies to determine user interests; the calculations could be done effectively within the device. Autonomous cars could also learn to adapt to their environment much faster using this method of learning.The potential impact of smarter machines really cant be overstated.

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A New Malaria Vaccine Was 100% Effective in Clinical Trials – Futurism

In Brief

Mosquitos are ugly creatures. They buzz, bite, and bother you, but more than just being annoying, they harbor parasites that transmit malaria. A person infected by one of these parasites via a mosquito bite can experience fever, chills, vomiting, and sometimes even death.

The World Health Organization predicts that almost 3.2 billion people thats half the worlds population are at risk of catching this disease, andamong those at risk, 214 million people were infected in 2015. Of those infected with malaria, at least 438,000 people passed away.

While global efforts have successfully reduced the incidences of malaria by 60 percent since 2000, researchers may have just found a way to take that progress even further thanks to a new malaria vaccine.

A malaria vaccine has been particularly elusive in the medical community because malaria originates from a parasite and not a virus. Therefore, a live but weakened form of the parasite that infects humans was used in the creation of this new investigational vaccine, Sanaria PfSPZ. The weakened sporozoites parasite was developed by Sanaria Inc. through a clinical study conducted by researchers from the National Institute of Healths (NIH) National Institute of Allergy and Infection Diseases (NIAID) division and the University of Bamako in Bamako, Mali.

The vaccine has shown to be 100 percent effective in U.S. clinical trials and 48 percent effective in those run in Mali. A principal investigator on the Mali trial, Dr. Sara Healy M.D., M.P.H., has noted that this level of sustained efficacy against malaria infection in a region with an intense transmission season has not been seen in previous malaria vaccine studies in Africa, establishing a positive outlook for the newly crafted vaccine.

Sanarias isnt the only malaria vaccine in development.GSKs malaria candidate vaccine,Mosquirix, is expected to roll out to the public in 2018. While its not expected to be as successful as PfSPZ, it is further ahead in development as PfSPZ has only just cleared Phase II clinical trials. Until recently, we had no true preventative measures against malaria, and now we just may have more than enough.

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A New Malaria Vaccine Was 100% Effective in Clinical Trials - Futurism

The Antarctic Ice Sheet Is the Smallest It’s Ever Been – Futurism

Melting Fast

The Antarctic ice sheet goes through a cycle of expansion and contraction every year. Ultimately, the ice that exists around the continent melts during the southern hemispheres summer, which occurs towards the end of February, and expands again when autumn sets in.

However, that melting is increasing dramatically.

This week, the US National Snow and Ice Data Center (NSIDC)announcedthat the sea ice contracted to just 883,015 sq. miles (2.28m sq. km). The announcement came on February 13, and these numbers mean that the ice is now at the smallest extent on record, reaching just a little smaller than the previous low of 884,173 sq. miles, which was recorded February 27, 1997.

NSIDC director Mark Serreze asserts that we will need to wait for measurements in the coming days before officially confirming this new all-time low; however, he is not optimistic. Unless something funny happens, were looking at a record minimum in Antarctica,Serreze told Reuters.

Climate change skeptics have often pointed to the tendency of the Antarctic ice sheet to expand as evidence against global warming. But with world average temperatures hitting an all time high in 2016, the impact of climate change on planet Earth is getting more pronounced and harder to deny. Weve always thought of the Antarctic as the sleeping elephant starting to stir, Serreze stated;Well, maybe its starting to stir now.

That said, all is not lost. Despite the hesitancy of some world governments when it comes to taking action against fossil fuels and climate change, efforts to reverse the effects of global warming are in no short supply.

The historic Paris Climate Agreement is one such step, with nations beefing up their efforts in transitioning from fossil fuels to renewable energylike solar, wind, and even nuclearpower.Moreover,a number of private effortsby companies like Microsoft, who plans to run on 50% renewables, and Tesla, who is pushing for electric cars andsolar powered roofs, provide hope for the future and make the case for renewable energy sources.

If we truly invest in theseefforts, future generations may never have to witness the Antarctic ice sheets receding to such low levels.

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Elon Musk: If Humans Are to Survive, We Must Merge With Machines – Futurism

In Brief

Elon Musk shocked the tech world this pastsummerwhen he explained both the concept and need for a neural lace at the 2016 Recode Code Conference.

The Neural Lace is a concept that has been a staple of science fiction. Its the idea of capturing the processes of the human mind with a tool and enhancing them to better suit our environment and lifestyle in one large, wirelessly connected interface among humans. Recently, this concept has taken a step forward in transitioning from the realm of fiction to non-fiction.

With their results published in Nature Nanotechnology, scientist Charles Lieber and his teamhave developed syringe-injectable electronics. Thus far, they has only been tested on live mice, but the results are promising. These electronics assist in monitoring brain activity, delivering treatment, and can even enhance brain activity. While human trials are years away, and the neural lace is currently a wired technology, the reason why Elon Musk finds it imperative is because of what it coulddo.

Elon Musk is making it very clear that the best way to avoid a dystopian nightmare is to form a symbiosis with machines. The need for this, he said on Monday in Dubai, could achieve a symbiosis between human and machine intelligence, and maybe solves the control problem and the usefulness problem.Since computers are able to transmit information an exponentially quicker than humans, becoming one with them would allow humans to stay relevant in an age where automation and technology threaten our usefulness as organic organisms. Additionally, having a wireless interface would help to keep us on a similar playing fieldessentially by making us part machine. So, while this cyborg idea of a future sounds ludicrous, when you consider how much of our reality is already sci-fi inspired, it makes a little bit more sense.

You can hear more about Musks thoughts on the necessary symbiosis between humans and machines in this recent video from CNBC.

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Elon Musk: If Humans Are to Survive, We Must Merge With Machines - Futurism

Hidden History: Connecticut Freedom Trail – WTNH Connecticut News (press release)

(WTNH) For slaves seeking freedom, it was a race against time.

Canada ended slavery in 1833 so Canada was kind of like the promised land for a fugitive, said Todd Levine, the Connecticut Freedom Trail.

The home of Uriel Tuttle in Torrington was a welcome safe haven on that journey of the Underground Railroad. The house was built around 1800. Tuttle opened his doors to escaped slaves and was dedicated to the abolitionist cause. At that time, helping slaves was illegal.

It became very dangerous for a family to become an underground railroad station, said Levine.

You could face up to six months in jail and up to $1,000 fine, which was a fortune back then. Hiding away runaway slaves wasnt always as covert and secretive as many people may think.

Another misconception is things like hidden tunnels, secret compartmentsthey do exist in some places, but generally the way the traveling slaves got to safe houses was traveling by night either by foot, wagon, horse or boat, said Levine.

They would likely walk right through the front door and then hide in the attic during the day.

Fugitive slaves were generally young men alone, not families. Generally, one single guy trying to make his way, said Levine.

Some slaves fought for their freedom in a different way hand to hand combat. Slaves on the ship, Amistad, used this technique.

South Africans were kidnapped and taken from their home and sold into slavery. They were on their way to a Cuban plantation when they rose up and took control of their vessel and tried to make their way back home, said Levine.

The ship ended up in New London, but the trial made it all the way to the Supreme Court, with many heroes stepping up along the way.

John Quincy Adams, former president, who came out of retirement to argue successfully that all men are created equal, said Levine.

Other heroes like Samuel and Catherine Deming who lived in Farmington in a house that is now part of Miss Porters School, were a beacon of hope for the Mendis and all slaves seeking freedom.

For the Underground Railroad, Farmington became Grand Central Station, said Levine.

After the Mendi slaves won their freedom, the Demings provided a place to stay.

What Deming did was building dormitories for them on his land in one of his buildings so that the Mendis could have a place to stay and learn, said Levine.

Other residents of Farmington rose up in support as well.

The whole town of Farmington came together including the municipality, in order to send these guys back home, said Levine.

Along the Freedom Trail to Norwich was the birthplace of David Ruggles. He was a free black man who is said to have helped over 600 slaves.

We do know a little bit about some of the folks he helped to rescue from slavery. One of them was Frederick Douglass, said Dale Plummer, City of Norwich Historian.

What we have learned is that folks in this community and others across the state really took a stand. Doing so back then was considered controversial.

Some very powerful people in the anti-slavery movement came from Connecticut, said Plummer.

They took courageous action toward protecting freedom and human dignity.

These are the stories of the freedom trail. These are the stories of overcoming impossible odds to gain their freedom, said Levine.

Click here for information on the number of Underground Railroad sites all around the state.

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Hidden History: Connecticut Freedom Trail - WTNH Connecticut News (press release)

Passivity and Freedom – First Things (blog)

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Ingolf Dalferth thinks we are Creatures of Possibility. By that, he means that we are creatures in the making whose actual becoming depends on possibilities beyond our control that occur in our lives as opportunities and chances that we can neglect and miss or take up and use (ix). We are free to choose and act, and we can determine the mode of our choosing and the way of our acting in moral terms. Yet this freedom depends on conditions that are beyond our control: we can choose and act and determine ourselves only against the backdrop of a basic passivity that characterizes our life and cannot be replaced or undone by anything we can do (x).

This is a fundamental reality of human life: Most of what we are we do not owe to ourselves. Our existence (Dasein), our particular way of existence (Sosein), and our truthful existence (Wahrsein) are all molded by passivity: There is so much that happens to us and so little that we make happen. Before I can act as a self, I must become a self, and while I cannot be a self without acting, I cannot become a self by acting. Before we can even us the nominative I, we first experience the dative and the accusative - we are objects and recipients. In short, A primal passivity precedes all our activity. Before we can give, we must be a given, and before we can act, we must be an actuality (xi-xii).

Action isn't a movement from passivity or activity; every action is in the middle voice. What he calls contrastive or horizontal passivity has a passive side and an active side, a capacity to be affected by others (receptivity) and a capacity to affect others (activity), and the two are polar opposites that allow for different degrees of mixture. But this middle-voiced action is the product of deep or vertical passivity, in which we are entirely passive (xii). Dalferth emphasizes the prior activity of the creator and the deep passivity of the creature that precedes everything creatures do and can do as creatures. There is no created freedom of creatures that is not embedded in and dependent on a prior and one-sided creative freedom of the creator that corresponds to a deep passivity in the creature (xiii, fn 5).

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Over Democrats’ objections, Senate OKs ‘religious freedom’ bill – wtvr.com

RICHMOND, Va. Democratic officials and the American Civil Liberties Union blasted Republican senators after they passed a religious freedom bill that would protect people who refuse to marry same-gender couples.

HB 2025, sponsored by Del. Nicholas Freitas, R-Culpeper, cleared the Senate on Thursday on a party-line vote of 21-19. The bill protects organizations and their employees who refuse to participate in the solemnization of marriage based on a sincerely held religious belief.

Freitas said the legislation was a response to Democratic Gov. Terry McAuliffes executive order that prohibits state contractors from discriminating based on sexual orientation.

This is simply about preventing the government from punishing a religious organization because it doesnt fit with a current governor or anyone elses interpretation of social standards, Freitas said when introducing the bill in committee.

The bill would protect a religious organization from losing a state contract or its tax-exempt status because of the groups beliefs regarding marriage. It also would protect individuals from losing state employment, grants or acceptance into a public university if they refuse to participate in the marriage of a same-sex couple.

Democrats, who unanimously voted against the measure, contended it would sanction discrimination against gay and lesbian couples. On Tuesday, Lt. Gov. Ralph Northam celebrated the third anniversary of a federal court ruling in the Bostic v. Rainey case legalizing same-sex marriage.

On Thursday, Northam, who is seeking the Democratic nomination for governor, criticized the Senate for approving HB 2025.

We cannot go backwards. We need to continue to be open and welcoming to all, no matter who you are or who you love, Northam said in a press release.

Claire Gastanaga, executive director of the ACLU of Virginia, urged her groups supporters to oppose HB 2025 and SB 1324, an identical bill that passed the Senate last week and is now before the House Committee on General Laws.

If these bills are signed into law, same-sex couples could be denied services at church-run facilities, hotels or resorts affiliated with religious organizations, or at hospitals owned by religious groups, even if the services are funded by taxpayers, Gastanaga said.

Del. Marcus Simon, D-Falls Church, argued on the House floor that HB 2025 is unnecessary because the Religious Freedom Restoration Act already makes it illegal for public bodies to discriminate against faith-based organizations on the basis of their religious beliefs.

A similar bill was introduced last year and failed in part because of the argument articulated by Simon.

However, Republicans said they fear that McAuliffes executive order could lead to discrimination against faith-based organizations that object to same-sex marriage.

We had the governors executive order, which I believe does just that, or at least creates a mechanism where that can be accomplished, Freitas said.

Democrats expressed concerns over the bills potential economic consequences. North Carolina experienced economic losses after its government passed a similar law last year.

At the beginning of the legislative session, McAuliffe vowed to veto any bill he considered discriminatory. Northam said the governor would veto HB 2025.

At his news conference Tuesday, Northam vowed to protect gay and lesbian Virginians from discrimination.

Just before the holidays, I completed a seven-city tour that ended in Salem, Virginia, where I was pleased to welcome the NCAA soccer tournament, Northam said. That championship was relocated from North Carolina after the state passed anti-LGBT legislation, as was the NBA All-Star game and major businesses. As long as Im here, as long as Gov. McAuliffe and Attorney General (Mark) Herring are here, Virginia will be inclusive. We will not be like North Carolina.

Carol Schall, one of the plaintiffs in the Bostic v. Rainey case, also spoke at the news conference. She discussed HB 1395, which would have repealed language in state law that bans same-sex marriage. Even though the language is no longer valid, the bill, sponsored by Del. Mark Sickles, D-Fairfax County, died in a House committee.

Names matter. Names like mom and wife make all the difference in the world, Schall said. In past years such as this year, Del. Sickles proposed to repeal outdated constitutional amendment encoding discrimination in our great Constitution.

Sickles called for a full House vote on the issue. He also discussed HJ 538, his proposal to repeal a constitutional amendment adopted by voters adopted in 2006 that defines marriage as being between one man and one woman. Sickles resolution died in a House committee on an unrecorded vote.

Constitutional amendments require approval in two legislative sessions before they can be presented to voters on a November ballot.

If this constitutional were passed and it passed again next winter, by the time it got to the voters in November of 18, 1.2 million people in our state will have come of age, Sickles said. They want to speak to this. They do not want the people of the 2006 cultural and societal milieu to speak forever.

By Julie Rothey with Capital News Service

CNS reporter Tyler Hammel contributed to this report.

Capital News Service is a flagship program of VCUs Robertson School of Media and Culture. Students participating in the program provide state government coverage for Virginias community newspapers and other media outlets, under the supervision of Associate Professor Jeff South.

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Over Democrats' objections, Senate OKs 'religious freedom' bill - wtvr.com

Detroit’s Freedom House may have to close – Michigan Radio

Detroit's Freedom House has lost its federal funding for the first time in more than 20 years. And it may have to shut down or substantially reduce its services.

Freedom House provides transitional housing and comprehensive services under one roof to asylum seekers who are fleeing persecution, rape and torture in their home countries.

Executive Director Deborah Drennansaid the U.S. Department of Housing and Urban Development denied Freedom House's grant application in December, and Freedom House has appealed the decision.

She said the amount requested, around $392,000, represents about 60% of Freedom House's total budget.

"The decision came to us as quite a shock with only three months notice," said Brennan.

Brennan said HUD has shifted priorities from transitional housing to permanent housing, but that shouldn't have counted against Freedom House's application.

"We meet HUD's criteria in outcomes," said Brennan. "Freedom House this past year had 94% of our residents who exited into permanent, stable housing without subsidies."

Drennan said the possibility of Freedom House's closing is causing great stress to its residents.

"Human life is at stake here," said Drennan. "People who don't have access to legal aid or housing, they become at risk for homelessness. They become at risk for being victims of human trafficking."

Drennansaid if asylum seekers are homeless, it is more likely they may be deported back to the countries they fled where they likely will be persecuted or even killed.

Freedom House has been helping asylum seekers since 1983. In the 1980s many of its residents were from El Salvador. Now the vast majority are from sub-Saharan Africa.

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Detroit's Freedom House may have to close - Michigan Radio

How Bears Breed Unicorns: Inside Cal’s Vast Startup Ecosystem – CALIFORNIA

How Bears Breed Unicorns: Inside Cal's Vast Startup Ecosystem
CALIFORNIA
Important as it is, the center is only one part of the startup ecosystem, a sprawling web of resources that includes an array of graduate and undergraduate classes, startup accelerators, incubators, competitions, mentoring, and funding mechanisms ...

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How Bears Breed Unicorns: Inside Cal's Vast Startup Ecosystem - CALIFORNIA