To your brain, spaceflight seems to be a lot like bed rest | Ars Technica – Ars Technica

Enlarge / The top row shows brain changes with long duration bed rest, the bottom row shows changes with spaceflight. Orange shows regions of increase, blue a decrease.

When it comes to human health and spaceflight, there are a lotof concerns as NASA casts its eye toward deep space. Among the more familiar problems are muscle and bone mass loss due to the lack of gravity. But more recently, scientists have grown increasingly concerned about astronauts returning to Earth withblurred vision, flattened eyeballs, and inflamed optic nerves after long-duration missions.

The eyesight problems appear to be caused by changes incerebrospinal fluid, a clear fluid that helps cushion the brain from pressure changes during bodily movements. Now scientists are probing what other kinds of health issues might be caused by a redistribution of this spinal fluid, and this has led to studying the changes in brain size during spaceflight.

A new study in Nature Microgravity provides some of the first data on the changes in brain structure during spaceflight. Led by University of Michigan researcherRachael Seidler, the study reviewedMRI scans from27 astronauts, 13 of whom flew space shuttle missions and 14 who had flown approximately six month increments on board the International Space Station. The data wasobtained fromthe NASA Lifetime Surveillance of Astronaut Health.

In their analysis, the scientists found "extensive" decreases in some gray matter areas, includingthecovering of the temporal and frontal poles and around the orbits. The effect was more pronounced for astronauts who had spent more time in space, and it's likely these changes were caused partially by shifting cerebrospinal fluid. The study also found increases in gray matter volume for regions of the brain that control leg movement. It's possible that these areas of the brain grew as the brain "worked" to learn how to move in microgravity.

These findings are preliminary and from a relatively small sample sizeas is often the case with astronaut studies. But there is enough data here for some basic conclusions. First of all, the brain clearly retains itsplasticity in space, learning and adapting to new motor skills in microgravity. Second, the space-based brain reaction is similar to patients observed ina long-term bed rest study intended to mimic microgravity, in which volunteers spent up to three months in downward tilted position.

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Blue Origin details new rocket’s capabilities, signs first orbital customer – Spaceflight Now

Artists concept of the New Glenn rocket. Credit: Blue Origin

Amazon.coms Jeff Bezos revealed new details of his space companys reusable orbital-class booster Tuesday, releasing an animation illustrating the rockets liftoff from Cape Canaveral and announcing a contract with Eutelsat to put a commercial communications satellite on one of the launchers first missions.

Speaking at the Satellite 2017 industry conference in Washington, Bezos said Blue Origins towering New Glenn rocket, named for pioneering astronaut John Glenn, could launch by 2020 and be reused up to 100 times.

Paris-based Eutelsat, one of the largest satellite telecom operators in the world, has signed up as the first paying customer for a New Glenn launch in 2021 or 2022.

Eutelsat is one of the worlds most experienced and innovative satellite operators, and we are honored that they chose Blue Origin and ourNew Glennorbital launch vehicle, Bezos said in a statement.

Eutelsat has launched satellites on many new vehicles and shares both our methodical approach to engineering and our passion for driving down the cost of access to space, Bezos said. Welcome to the launch manifest, Eutelsat, cant wait to fly together.

The New Glenns primary base will be at Cape Canaveral, where Blue Origin is constructing a cavernous rocket factory just outside the gates of NASAs Kennedy Space Center. Blue Origin has started preliminary earthmoving work for a launch pad at Complex 36, a former Atlas rocket facility at nearby Cape Canaveral Air Force Station, and plans to install an engine test stand at neighboring Complex 11.

The animation released by Blue Origin on Tuesday shows the New Glenn rocket taking off from Complex 36 on the power of seven BE-4 main engines, burning a mixture of liquefied natural gas and liquid oxygen. The engines each produce about 550,000 pounds of thrust at full throttle, combining to generate 3.85 million pounds of thrust at liftoff.

The first stage engines will give way to a single modified BE-4 engine on the New Glenns second stage to deliver satellites, and eventually crews, into orbit, while the booster flips around and reignites to slow its descent toward a barge positioned offshore in the Atlantic Ocean, according to Blue Origin.

The New Glenn first stage will have aerodynamic fins, or strakes, for improved steering and extend six landing legs just before touchdown.

The recovery maneuver is familiar to industry officials and space enthusiasts, bearing similarity to the landings pioneered by rival SpaceX.

Blue Origin held a patent on its plans to land rocket boosters on ships in the ocean using rocket thrust to slow the vehicles down for landing, but SpaceX disputed the validity of the patent claims by pointing to academic papers and proposals dating back decades outlining concepts to recover rockets on ocean-going vessels for refurbishment and reuse.

Blue Origin in 2015 canceled the claims disputed by SpaceX, which achieved its first rocket landing at sea in April 2016.

The two-stage New Glenn variant, shown in the animation, will stand270 feet (82 meters) tall and haul nearly 29,000 pounds, or 13 metric tons, to geostationary transfer orbit, the drop-off point for most communications satellites, like the platforms owned and operated by Eutelsat. The rockets payload capacity to low Earth orbit, a few hundred miles in altitude, will be nearly 100,000 pounds, or 45 metric tons, Bezos said.

With the addition of an optional third stage for deep space missions, the New Glenns height will increase to 313 feet (95 meters).

Blue Origins BE-4 engine in development to power the New Glenn rocket is scheduled to perform its full-scale hotfire test later this year at the companys remote West Texas test site.

Bezos tweeted two pictures of the first fully-assembled BE-4 engine Monday, adding that the second and third copies are following close behind.

United Launch Alliance has tapped the BE-4 engine as its preferred powerplant for the next-generation Vulcan rocket scheduled for a maiden launch in 2019. ULA is paying Aerojet Rocketdyne, a traditional engine-builder, to continue developing its kerosene-fueled AR1 engine as a backup option.

We are very close to selecting, said Tory Bruno, president and CEO of ULA, in a Feb. 16 presentation at the University of Texas at El Paso. And if the testing that happens in the next couple of months is successful, well probably end up on that Blue Origin (engine).

The BE-4 and AR1 will employ astaged combustion cycle, a more efficient engine cycle than currently available on other U.S. liquid hydrocarbon rocket engines. Staged combustion engines currently flying include the Russian RD-180 on ULAs Atlas 5, which the Vulcan will replace.

Itll be very exciting because itll bring that advanced Russian engine cycle technology to America, and it will make it much much better because this engine will be additively manufactured, Bruno said. It will be much more produceable. It will be much lighter, and it will be much much more affordable.

Blue Origins first production engine, the BE-3, burns liquid hydrogen and liquid oxygen and flies on the companys suborbital New Shepard rocket. The New Shepard has launched successfully six times, including five straight vertical liftoffs and landings with the same reusable single-stage booster in 2015 and 2016.

Eutelsat has taken chances on new rockets before, placing its satellites on the inaugural launches of the Atlas 3, Atlas 5, Delta 4 and Ariane 5 ECA boosters in the early 2000s.

In a statement Tuesday, Eutelsat said the contract with Blue Origin reflects Eutelsats longstanding strategy to source launch services from multiple agencies in order to secure access to space.

Eutelsat said the New Glenn launcher will be compatible with virtually all of its satellites, allowing the company to assign a spacecraft to the mission 12 months ahead of time.

Blue Origin has been forthcoming with Eutelsat on its strategy and convinced us they have the right mindset to compete in the launch service industry, said Rodolphe Belmer, CEO of Eutelsat. Their solid engineering approach, and their policy to develop technologies that will form the base of a broad generation of launchers, corresponds to what we expect from our industrial partners.

In includingNew Glennin our manifest, we are pursuing our longstanding strategy of innovation that drives down the cost of access to space and drives up performance, Belmer said in a statement. This can only be good news for the profitability and sustainability of our industry.

Email the author.

Follow Stephen Clark on Twitter: @StephenClark1.

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Blue Origin details new rocket's capabilities, signs first orbital customer - Spaceflight Now

This family home with sea views will make you hanker for a move to … – Press and Journal

Beautiful views of open countryside and room for a growing family await at One Midtown Steading near Peterhead.

This lovely semi-detached converted steading can be found just outside the village of Hatton and has all the benefits of rural life.

With four bedrooms and a showhome-style interior, youll be eager to make it your new home right away.

The design means the hallway provides access to all downstairs accommodation and double doors lead into the impressive lounge.

This is the ultimate room for entertaining with sleek and stylish decor.

Under-floor heating will be a particularly welcome feature in winter and has been installed on the entire ground floor.

Whether youre entertaining guests or unwinding at the weekend, the lounge provides the perfect spot.

The kitchen is equally spacious and comes well equipped, with plenty of storage space.

Those who love cooking will find themselves making the most of the ample work unit space.

Theres plenty of room for dining furniture should you wish to entertain guests or simply come together as a family.

Two double bedrooms can be found downstairs, both of which have built-in wardrobes.

This layout will be particularly convenient for teenagers wanting their own space away from mum and dad but would also be ideal for guest bedrooms.

The family bathroom has been fitted with a three-piece suite and shower-over-bath.

Completing the downstairs accommodation is a handy utility room.

The remaining two bedrooms can be found upstairs.

Both offer extensive wardrobe space but the highlight has to be the large Velux windows in each room.

Panoramic views stretching towards the sea mean youll be eager to open the blinds each morning.

Theres the further convenience of a shower room which has a two-piece suite, and has been finished to a high standard.

Midtown Steading is accessed via electronic gates and there is parking for several cars on the driveway.

Theres also a large garage and further enclosed parking to the rear.

The rear garden is enclosed and would be perfect for children.

It has been laid to lawn and will be easy to maintain, and the current set-up includes a lovely alfresco dining area.

There are stunning views of the open countryside with the sea on the horizon.

There are plenty of amenities in Hatton, and both Ellon and Peterhead are only a short drive away.

Offers should be made in excess of 324,000.

Contact Aberdein Considine on 01358 721893.

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Is red hair gene linked to increased risk of Parkinson’s? – NHS Choices – NHS Choices

Monday March 6 2017

Red hair could be a risk factor for Parkinson's

"Redheads are more likely to develop Parkinson's," claims the Mail Online after astudy found the gene that makes people with red hairsusceptible to skin cancer also increases the risk of brain disease.

But the study didn't actually look directly at redheads (human ones, anyway). Instead, it used mice to look at whether a red hair gene called MC1R might be important in the region of the brainaffected by Parkinson's. The study found the MC1R gene was active in this brain region in mice.

When researchers stopped the gene working, it led to nerve cells in this region dying, resulting in the mice developing progressive problems with movement.

The researcherssuggested drugs targeting MC1R might help in treating Parkinson's.

The causes ofParkinson's disease in humans are not completely understood. While this research supports the possibility this gene plays a role, there are likely to be other genetic factors involved, as well as environmental factors.

Not all studies in humans have found a link between variants in the MC1R gene and Parkinson's. Even if there is some increase in risk associated with certain forms of this gene, it's likely to be relatively small.

The study was carried out by researchers from Massachusetts General Hospital, Harvard Medical School and the University of California in the US, and the Tongji University School of Medicine in China.

The work was funded by the National Institute of Neurological Disorders and Stroke, the National Natural Science Foundation of China, the RJG Foundation, the Michael J Fox Foundation, the Milstein Medical Asian American Partnership Foundation, and the US Department of Defense.

The news headlines fail to capture the uncertainty about whether redheads are at greater risk of Parkinson's. Some studies have suggested this may be the case, but the evidence isn't conclusive.

The current research didn't look at this question directly it looked at whether researchers could find a biological reason why there might be a link.

This animal research looked at how a gene that determines whether people have red hair might also play a role in Parkinson's disease.

Other studies have suggested people with malignant melanoma a skin cancer more common in redheads and fair-skinned people might be at greater risk of Parkinson's. Studies have also shown higher than expected rates of melanoma in people with Parkinson's.

The researchers thought the link between the two conditions might be down to a gene called the melanocortin 1 receptor (MC1R) gene. People who carry certain versions of the MCR1 gene tend to have red hair and fair skin.

Some studies but not all have suggested carrying certain red hair MC1R variants and having red hair are also associated with an increased risk of Parkinson's disease.

The researchers wanted to look at whether the MC1R gene has an effect on nerve cells in the brain that produce a specific signalling chemical called dopamine.

In Parkinson's, these nerve cells die off, which causes the slow movement problems characteristic of the disease. If the gene is important in these cells, this would explain why there might be a link between red hair and Parkinson's.

Humans and other animals share many of their genes, so researchers often investigate what genes do in animals to give strong pointers of their roles in humans.

The researchers studied mice with a defective form of the MC1R gene. These mice have yellow coats, the equivalent of red hair in humans. The researchers compared these with normal mice with functioning MC1R genes.

They first looked at whether the MC1R gene in normal mice was active in the dopamine-producing nerve cells in the part of the brain affected by Parkinson's disease, the substantia nigra.

They compared the abnormal mice with the non-functioning MC1R gene and the normal mice to see whether the substantia nigra looked different and whether the mice moved differently. They also looked at how the defective gene might affect brain cells.

One way of producing mice with a Parkinson's-like condition is by exposing them to chemicals that kill the dopamine nerve cells.

The researchers looked at whether the abnormal mice were more susceptible to two different chemicals that can do this.

Theythen looked at whether "switching on" the protein made by the MC1R gene chemically might protect normal mice against the effects of one of these Parkinson's-inducing chemicals.

The researchers found the MC1R gene was normally active in the dopamine-producing nerve cells of the substantia nigra, which are typically affected by Parkinson's disease.

Mice with aninactive MC1R geneshowed progressive problems with their movement. They moved around less in an open area compared with normal mice of a similar age, and the problem got worse as they aged.

These mice appeared to be losing dopamine-producing nerve cells in the substantia nigra.

Additional experiments suggested brain cells in these mice had more DNA damage from naturally occurring chemicals called free radicals.

The abnormal mice were more susceptible than normal mice to two different Parkinson's-inducing chemicals.

The researchers also found chemically activating the protein made by the MC1R gene in normal mice reduced the effects of these toxic chemicals.

The researchers concluded that genetically "shutting off" MC1R signalling in mice leads to the death of some dopamine-producing nerve cells.

Conversely, "switching on" MC1R signalling helps protect these cells from damage by chemicals that normally produce Parkinson's-like effects in mice.

The researchers suggest this may mean drugs that target MC1R might help in Parkinson's. It also supports the possibility that the MC1R gene plays a role in the risk of both melanoma and Parkinson's disease.

This study looked at the role the red hair gene MC1R playsin the brains of mice. The findings suggest the gene has a part to play in keeping certain nerve cells in the brain alive.

The cells in question are those that die off in Parkinson's disease and cause the condition's characteristic movement problems.

These findings in mice are likely to need further investigation in human cells and tissue in lab studies.

Exactly what causes brain cells to die, causingParkinson's disease, is unknown. As with many conditions, it's thought both genetic and environmental factors could play a role.

Research like this helps us gain a better understanding of the disease and how it might be treated or prevented.

But Parkinson's is a complex disease, and this new study has only looked at one small piece of a much bigger puzzle. For redheads, it may be comforting to know this link has not yet been proven beyond a doubt.

And not all studies in humans have found a link between variants in the MC1R gene and Parkinson's. In fact, a recent systematic review by some of the authors of this study looked into this.

The review gathered studies published to date that have investigated the link between red hair variants of the MC1R gene and Parkinson's disease.

Six studies assessing links with two variants of this gene were identified, but the studies couldn't quite exclude the possibility of no effect when pooled.

The review also identified two studies looking at hair colour. These studies found people with red hair were more likely to develop Parkinson's than people without red hair.

But these observational studies have several limitations notably, they can't prove clear cause and effect because many other genetic, environmental and lifestyle factors could also be influencing any links seen.

And even if there is some increase in risk caused by this pigment gene, it's likely to be relatively small.

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Is red hair gene linked to increased risk of Parkinson's? - NHS Choices - NHS Choices

Kristen Stewart Debuts Her Shaved Head on the Red Carpet – E! Online

Frazer Harrison/Getty Images

Kristen Stewartis showing offa brand-new look.

At the Los Angeles premiere for her new movie Personal Shopper, the actress stepped out in a black crop top and matching pants.

Ultimately, it wasn't the fashion fans were talking about. Instead, it was Kristen's much shorter (and blonder) hairstyle that turned heads on the red carpet.

Whether posing solo or with director Olivier Assayas, Kristen certainly got fans talking while stepping out at The Carondelet House in Los Angeles.

For those wondering why she changed her hair so drastically, there appears to be a big reason behind the buzzed cut.

Alberto E. Rodriguez/Getty Images

As it turns out, the styleis reportedly for her upcoming movie titled Underwater. The thriller tells the story of a crew of underwater researchers who must scramble to safety after an earthquake damages their laboratory.

Before filming concludes on that project, Kristen is focused on Personal Shopper. The very-modern thriller has to do with our relationship with new forms of communication.

While covering V Magazine's "Free Spirit" issue, the actress couldn't help but share her own experiences with technology.

"When you speak to someone on the phone, that is a decipherable, understandable exchange," she explained. "But with text and social media, it's essentially a dialogue with yourself and your interpretation of a shadow. It's not invalid; it's a new language."

Personal Shopper hits theatres this Friday.

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Kristen Stewart Debuts Her Shaved Head on the Red Carpet - E! Online

House passes NASA authorization bill – SpaceNews

The NASA Transition Authorization Act of 2017 is the first NASA authorization bill to clear both houses of Congress since the fall of 2010.

WASHINGTON For the first time in nearly six and a half years, Congress has passed a NASA authorization bill with the approval of such a bill March 7 in the House of Representatives.

The House approved on a voice vote the NASA Transition Authorization Act of 2017, S.442, after a brief discussion on the House floor where no members spoke against the bill. The same bill passed the Senate by unanimous consent Feb. 17.

The bill authorizes $19.5 billion in spending for NASA in fiscal year 2017. More importantly, it includes a number of policy provisions directing NASAs activities. They range from development of a detailed plan for NASAs human exploration programs, with the long-term goal of sending humans to Mars, to giving NASA the ability to establish long-term medical monitoring of former astronauts.

This bipartisan and bicameral bill grew to maturity through many long and serious discussions about the future of our nations space program, said Rep. Brian Babin (R-Texas), chairman of the House space subcommittee, during discussion about the bill on the House floor. Im encouraged by the bills persistent emphasis on the continuity of purpose and stability.

The bill is nearly identical to a bill the Senate passed in December, just after the House adjourned for the year. The new version includes a few provisions not found in the earlier one, including language directing NASA to study the use of the Orion spacecraft as a crew transfer vehicle for the International Space Station as a stopgap if commercial crew vehicles suffer additional delays.

While the bill had broad support, some members highlighted areas of concern that may become issues in later legislation. It is not a perfect bill, said Rep. Eddie Bernice Johnson (D-Texas), ranking member of the House Science Committee. It does not directly address all of NASAs science programs, mainly Earth science and heliophysics. She said she was also critical of authorized funding levels for NASAs science, aeronautics and space technology accounts, but added she supported the bill overall.

The NASA Transition Authorization Act of 2017 reaffirms our support for the bold visions and commitments that will shape Americas future in space, Rep. Lamar Smith (R-Texas), chairman of the House Science Committee, said in a statement after the bills passage. This bill reiterates the importance of maintaining NASAs continuity of purpose to ensure America remains a leader in space exploration.

The bill is the first NASA authorization to pass both houses of Congress since the NASA Authorization Act of 2010, which the House passed in September 2010 nearly two months after it cleared the Senate. The House worked on several authorization bills in subsequent years, including some which passed the full House, but none made it through the Senate.

This bill had a smooth ride through the House and Senate because of work behind the scenes to address issues before the bill was introduced in the Senate last month. In a January interview, Smith said he and Sen. Ted Cruz (R-Texas), chairman of the Senate space subcommittee, had been working to pre-conference the bill to resolve any problems before its introduction, allowing for a streamlined passage through both Houses. The bill also has the support of the White House, according to congressional sources.

The space industry welcomed the bills passage. Todays approval of the NASA Transition Authorization Act by Congress sends a clear message to the American people and our international partners that our nation remains committed to NASAs space exploration program, Mary Lynne Dittmar, executive director of the Coalition of Deep Space Exploration, said in a March 7 statement.

Dittmar cited the support the 2010 authorization bill provided for human exploration programs, such as the Space Launch System and Orion, as well as space science programs. This new authorization will provide the framework for continued progress towards these national commitments, she said.

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House passes NASA authorization bill - SpaceNews

NASA to Test Orion Space Capsule Parachute – Space.com

A test of the Orion human space capsule's parachute system in December 2012. NASA plans to conduct another Orion drop test on March 8, 2017.

The NASA spacecraft that could one day help ferry humans to Mars is scheduled to undergo a parachute test tomorrow (March 8).

The Orion spacecraft can carry humans on long trips into deep space, but once it returns to Earth, it needs a little help touching down. Like the Apollo spacecraft, Orion relies on a parachute system to lower it down through Earth's atmosphere, and safely return astronauts to the ground.

The test is scheduled to take place at 7:30 a.m. local time (9:30 a.m. EST/1430 GMT) at the U.S. Armys Yuma Proving Ground in Arizona. A model of Orion will be dropped from a C-17 aircraft flying at an altitude of 25,000 feet, according to a statement from the agency. NASA is currently investigating the possibility of flying two astronauts on a test flight of the Orion spacecraft as early as 2019.

Tomorrow's parachute test will simulate what would happen if an abort sequence took place during Orions launch. If something goes wrong with NASA's Space Launch Systems (SLS) rocket that Orion is riding on, NASA officials may decide to abort the flight, meaning the spacecraft would be ejected from its seat atop the rocket. In such an event, the parachutes would deploy and drop the spacecraft safely back to Earth. During an abort sequence, the spacecraft will be traveling at the relatively slow speed of about 130 mph [210 km/h], rather than speeds of about 310 mph [500 km/h] during re-entry after reaching space, according to NASA. The drop will last for about four minutes total; the last one to two minutes will take place under fully deployed parachutes, according to a NASA representative.

Orion's parachute system consists of 11 parachutes in total: three forward bay cover parachutes (deployed first), two drogue parachutes (deployed second, at about 25,000 feet), and three pilot parachutes (deployed at about 9,500 feet) that subsequently deploy three main parachutes. The parachute system can slow down the space capsule to just 20 mph [32 km/h] before touchdown, according to NASA. During tomorrow's test, the Orion team will focus on "deployment of Orion's two drogue parachutes at low speeds, and deployment of its three main parachutes in preparation for landing."

This will be Orion's second airdrop parachute test in a series of eight qualifying drop tests that will replicate various scenarios in which Orion's parachute system would need to be deployed, according to the statement.

Follow Calla Cofield @callacofield. Follow us @Spacedotcom, Facebook and Google+. Original article on Space.com.

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NASA Is About to Create the Coldest Place in the Known Universe – ScienceAlert

NASA is about to launch the coldest place on Earth - the Cold Atom Laboratory (CAL) - into orbit, where astronauts will use it to create never-before-seen conditions with temperatures 100 million times colder than the depths of space.

The Cold Atom Lab will hitch a ride on a SpaceX rocket to the International Space Station, where it's hoped the super-chilled box will reveal strange new physics when atoms are cooled to a mere billionth of a degree above absolute zero.

"Studying these hyper-cold atoms could reshape our understanding of matter and the fundamental nature of gravity," said CAL project scientist Robert Thompson, from NASA's Jet Propulsion Laboratory.

"The experiments we'll do with the Cold Atom Lab will give us insight into gravity and dark energy - some of the most pervasive forces in the Universe."

In case you've never considered what the coldest place on Earth was until about 30 seconds ago, NASA's Cold Atom Laboratory is an ice chest-sized box equipped with lasers, a vacuum chamber, and an electromagnetic 'knife' to slow particles to an almost motionless state.

The instrument is still in its final stages of construction, so this mission, set to launch in August, will be its first big test.

The plan is to fill the Cold Atom Lab with gas particles aboard the International Space Station, where the unique microgravity environment will allow researchers to observe never-before-seen quantum phenomena that are impossible to detect on Earth.

Of particular interest is the exotic form of matter called Bose-Einstein condensate - a 'superfluid' state where atoms morph into mysterious waveforms that have never been observed at Cold Atom Lab temperatures.

Because this state has zero viscosity, atoms are able to move without friction, as if they were a single, solid substance, NASA explains.

"If you had superfluid water and spun it around in a glass, it would spin forever," says Anita Sengupta, the Cold Atom Lab project manager.

"There's no viscosity to slow it down and dissipate the kinetic energy. If we can better understand the physics of superfluids, we can possibly learn to use those for more efficient transfer of energy."

Bose-Einstein condensates are of particular interest to physicists because in this state, the rules switch from classical physics - such as Einstein's theory of general relativity - to quantum physics, and matter starts to behave less like particles and more like waves.

Understanding this transition is the key to one of the biggest open questions in modern physics - when used separately, general relativity and quantum field theory can explain the largest and smallest things in the Universe respectively, but no physicist has ever managed to unify the two into a much-coveted 'theory of everything'.

For that reason, physicists would love to stare at Bose-Einstein condensates for days, but because Earth's gravitational pull puts a swift end to the free fall state necessary to maintain this exotic matter, it's usually only observable for a few fractions of a second.

In the microgravity environment of space, however, scientists should be able to get a much more substantial view of things - NASA predicts they'll be able to maintain Bose-Einstein condensates in the Cold Atom Lab for up to 5 to 10 seconds in space.

Not only could this help us figure out what binds classical and quantum physics together, but a better understanding of Bose-Einstein condensates could lead to more accurate sensors, telescopes, and the atomic clocks used in spacecraft navigation, and could even speed up the race towards the world's first quantum computer.

"Like a new lens in Galileo's first telescope, the ultra-sensitive cold atoms in the Cold Atom Lab have the potential to unlock many mysteries beyond the frontiers of known physics," says Kamal Oudrhiri, deputy project manager of the CAL.

Hurry up, August - we need to see this thing in action!

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NASA Is About to Create the Coldest Place in the Known Universe - ScienceAlert

House Passes Bipartisan $19.5 Billion NASA Reauthorization Bill – Wall Street Journal (subscription)


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House Passes Bipartisan $19.5 Billion NASA Reauthorization Bill
Wall Street Journal (subscription)
The House on Tuesday followed the Senate's lead by adopting bipartisan legislation supporting all of NASA's major manned exploration programs but for the first time designated human settlement of Mars as one of the agency's explicit long-term goals.
With eyes on Mars, Congress sends NASA bill to TrumpHonolulu Star-Advertiser
Moon, Mars the goal of NASA funding bill on President Trump's deskNews 13 Orlando
Congress Passes NASA Reform, Reauthorization BillLaw360 (subscription)

all 42 news articles »

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NASA: The Beating Heart of America’s Innovation Industry – Big Think

Bill Nye: Well, talking some more about me, I'm the CEO of The Planetary Society so what I have encouraged the staff to do is focus on our mission. Our mission is exploring the planets, to know the cosmos and our place within it, empowering citizens of the world to be space explorers. So by focusing on your core mission I think it will enable us to work together to make the world better. Now when it comes to NASA, we are very hopeful is that we will acknowledge that NASA is a fantastic envoy or it's a fantastic brand for the United States. People everywhere no matter how they feel about the United States respect what NASA is able to accomplish. First of all when it comes to exploring Mars, which is what we all want to do everybody talks about all the time, let's not have a reset, let's not cancel existing programs for the sake of some imagined or proposed new program, let's finish the Space Launch System, let's finish Orion, let's enable the Falcon heavy to be built and fly this rocket from SpaceX. If United Launch Alliance wants to build the Vulcan let's enable that. Let's do everything all at once in the human spaceflight and stay focused on getting to Mars by setting a date.

One of my favorite blues songs is Set A Date, and he's talking about I believe getting married, but if we set a date for when we would be on Mars we would be much more likely to achieve it than to continually suggest decades from now. And as you may know the Planetary Society did an analysis that shows we could be in orbit around Mars, which would be analogous to the Apollo 8 orbit of the moon in 2033 without changing anything about the NASA budget just adjusting it for inflation. But if people got excited and wanted to go a couple orbits early in 2028 that would be fantastic. That's for one thing. The other thing that we at the Planetary Society very much want NASA to stay focused on are these extraordinary planetary missions. We have Juno in orbit around Jupiter, we have Curiosity and Opportunity still roving on Mars. We have many spacecraft in orbit around Mars. We have New Horizons data is still coming back from I guess it just finished bringing data back from Pluto and now it's onto the next destination in deep the space in 2019.

Keep those missions going because that's where new things happen, where these innovations happen in technology. A very strong argument can be made that we would not have this conversation electronically on the Internet without the U.S. space program, which led to the development of the Internet and so on. So acknowledge that NASA is a great international brand as well as a source of national pride and technological achievement. And I will say to the fossil fuel industries if you're out there, think about making your mission energy production rather than fossil fuel extraction and burning. I mentioned this to executives at Exxon before it was Exxon Mobile many times back in the 1990s when I was working with you all that if you were an energy company rather than a fossil fuel extraction company you could be part of the future instead of part of the past.

Everybody understand no matter what you may think about the energy needs of the United States right now, the future is not going to be coal and oil, it's just is not going to be. Look at it this way, other countries are not going to buy products made with fossil fuels in the future, they're going to put essentially a tax on it, a tariff and the longer we stay the fossil fuel course the more likely we are to run aground. There's a little nautical metaphor for you. But there's just no future in it. I love you all but there's no future in it.

So appreciate the space program's place in the world, both for technological achievement and for statesmanship. And working together we can provide renewable clean electricity for everyone on earth if we just get to work. Let's go.

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NASA: The Beating Heart of America's Innovation Industry - Big Think

Shedding light on NASA’s ‘Hidden Figures’ – Virginia Gazette

Although the movie "Hidden Figures" didn't win any Oscars, it won the hearts and minds of the large audience that packed the Kimball Theatre last Wednesday evening.

The special screening of the movie arranged by Marianne Johnson, Kimball's program manager, was introduced by Dr. Joel Levine, who spent 41 years as a senior scientist at NASA and knew one of the film's real-life heroines. Both the movie and Levine received standing ovation.

The trailer for 'Hidden Figures' describes as "the incredible untold story of Katherine G. Johnson, Dorothy Vaughan and Mary Jackson, brilliant African-American women, who served as brains behind one of the greatest operations in history, the launch of astronaut John Glenn into orbit, an achievement that restored the nation's pride and confidence."

Levine, who serves now as research professor at the College of William & Mary's Department of Applied Science, told his audience about the history of NASA, originally called National Advisory Committee on Aeronautics, and the Langley Aeronautical Memorial Laboratory, where in 1935 five white women, joined the first computing pool. They were called, "women computers" and they ran calculations on mechanical adding machines. The first black women joined Langley in 1943, in the segregated "West Computer" or "Colored Computer" pool.

By 1946, 400 human computers worked at Langley, and as Bill Barry, NASA Chief Historian noted, "women were much more accurate, much faster and did a better job than men and you could pay them less money than men."

I asked Levine whether he was aware of the important role "women computers" played in NASA's space program.

"I was not really aware of it," he said in an interview with the Gazette. "When I arrived at NASA Langley in 1970, I worked with several women who were originally hired as "computers." They were now engineers, mathematicians and technical editors. Of the three women portrayed in the movie, I only knew Mary Jackson. My wife, Arlene, who worked in the same building as Mary Jackson, knew her much better."

Arlene, worked at NASA for 27 years as coordinator of Green Activities at the Strategic Relationship office. She was also the investigator and author of the scholarly paper on the psychological effects of long-duration space missions and stress amelioration techniques. She earned a mile-long list of awards.

No wonder, when I asked Levine who had the greatest influence on the development of his scientific career, he said without hesitation, "Arlene, my wife of 50 years. She has always been very supportive of my career, its development and its demands."

Reflecting on the dramatic scenes in the movie 'Hidden Figures,' portraying racial segregation at Langley, Levine said, "When I arrived at NASA Langley in July 1970, the Center was totally integrated. The 'computer women' that I personally knew, both black and white were highly intelligent, hardworking and very friendly."

Not surprisingly, the three black women portrayed in the movie had a stellar career at NASA. According to a NASA statement, "Katherine Johnson's calculations proved to be critical to the success of the Apollo Moon landing program and the start of the Space Shuttle program.... In 2015, President Barack Obama presented Johnson with the Presidential Medal of Freedom."

Dorothy Vaughan, was the first black supervisor at the agency and worked at Langley for 28 years. She taught herself and other women computer programming languages and prepared them for the transition to electronic computers.

Mary Jackson, after 34 years at NASA, had achieved the most senior title within the engineering department. She served as Federal Women's Program Manager and worked to influence the career path of women in science, engineering and mathematical positions.

Shatz is a Williamsburg resident. He is the author of "Reports from a Distant Place," a compilation of his selected columns. The book is available at the Bruton Parish Shop and amazon.com.

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Shedding light on NASA's 'Hidden Figures' - Virginia Gazette

NASA Astronauts Can Now 3D-Print Pizzas in Space – Futurism

In Brief

Now that 3D-printing technology has become more vital and relevant than ever, Silicon Valley startup BeeHexhas harnessed this technology to 3D print pizza. Yes, you read that right. Edible, cheesy, delicious pizza can now be printed by a pre-programmed robot.

Funded by a grant from NASA, the purpose of this invention wasto create a way for astronauts to select and producedelicious food for themselves on missions. As manned missions to Mars become an ever-increasing possibility, astronauts might be spendingmuch more time in space. To save space-goers from the drudgery of choking downfreeze-dried, pre-packaged space food day after day, month after month, NASA decided it was time to develop a way to cook in space.

This technology will soon be adopted commercially for us Earth-dwellers as well. The robot, which has raised$1 million in funding, will be branded as the Chef 3D. The Chef 3D is set to appear at theme parks, malls, and even sports arenas.

While this maybe yet another technology that replaces existing jobs for humans, it will be capable of creating food more quicklyand cleanly than a human chef could. Who knows, perhaps the next time you go to see your favorite sports team play, you will be snacking onrobot food.

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NASA Astronauts Can Now 3D-Print Pizzas in Space - Futurism

Nanotechnology | Life Sciences | Industry Teams | Services …

Foleys Nanotechnology attorneys help you realize the potential of your nano-enabled innovations such as cleantech and nanobiotechnology by protecting your IP assets, building financial interest, evaluating your technologys potential, navigating changing regulatory compliance, and aiding the management of your business and industry risks.

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Your IP assets may be worth more than your company, and building a solid, protected patent portfolio is one way to bolster your competitive advantage. As IP counsel to some of the nations top nanotechnology labs, our Nanotechnology attorneys can help you develop an offensive strategy to protect and leverage your IP, and an in-depth understanding of how your decisions today regarding licensing, tech transfer agreements, strategic alliances, start-up acquisitions, and confidentiality and trade secret matters can affect your commercial viability down the road.

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If you are an emerging company, we can help you secure critical financing by leveraging your IP assets and building and communicating a licensing strategy that piques the interest of investors, while affording you the maximum portfolio protection.

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Entering into a deal with the federal government or one requiring compliance with extensive federal regulations is fraught with risk and opportunity, as long as you know where and how to go about it. We have Nanotechnology attorneys in our Washington, D.C. office who are at the heart of all things governmental, and are particularly skilled with finding opportunities for clients to conduct business with the federal government. We can counsel you on key procurement issues and strategies, negotiate contracts, file and defend bid protests, negotiate claims settlements, litigate contract disputes and claims, and assist you in obtaining statutory relief from the U.S. Congress when necessary.

The continuing uncertainty about the impact of environmental, health, and safety (EHS) issues on nanotechnology has resulted in increasing regulation from government agencies like the FDA, EPA, and USDA. We can help you anticipate and proactively address regulatory obstacles by monitoring U.S. regulatory changes, developing a strategic approach to address public concerns relating to EHS issues, and providing advice on regulatory approval process.

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Global Nanotechnology Market Outlook 2016-2024 Featuring Altair … – Yahoo Finance

DUBLIN, Mar 01, 2017 /PRNewswire/ --

Research and Markets has announced the addition of the "Global Nanotechnology Market Outlook 2024" report to their offering.

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The global nanotechnology market is expected to grow at a CAGR of around 17% during the forecasted period of 2017-2024.

Nanotechnology is a rapidly growing technology with potential applications in many sectors of global economy namely healthcare, cosmetics, energy and agriculture among others. The technology is revolutionizing every industry while tremendously attracting worldwide attention.

Thus, there lies a great opportunity for industry participants to tap the fast growing market which would garner huge revenue on the back of commercialization of the technology.

In 2016, the global nanotechnology market has shown impressive growth owing to factors, like increase in government and private sector funding for R&D, partnerships & strategic alliances between countries and increased in demand for smaller and more powerful devices at affordable prices. At present, the healthcare industry is one of the largest sectors where nanotechnology has made major breakthrough with its application for the diagnosis and treatment of chronic diseases like cancer, heart attack etc. Further, significant developments are also being done in other sectors like electronics, agriculture, and energy.

In this report, the analysts have studied the current nanotechnology market on segment basis (by application, by component and by region) so as to provide an insight on the current market scenario as well as forecasts of the aforementioned segments till 2024. The report provides an in-depth analysis of all the major segments, taking into account the major developments taking place at global level in the respective segments that will further boost the growth of nanotechnology market.

Further, the application section covers the use of nanotechnology in electronics, energy, cosmetics, medical, defence, and food and agriculture sectors while the component section covers the segregation of nanotechnology market into nanomaterials, nanotools, and nanodevices.

Additionally, the report covers the country-level analysis of 13 major countries like the US, France, UK, Germany, and Russia among others in terms of R&D, nanotechnology patent analysis, funding and regulations, to provide an in-depth understanding about the investments and recent research & developments done in the field of nanotechnology.

Besides, the report covers the profiles of key players like Altair, Nanophase Tech, Nanosys, etc. with the key financials, strength & weakness analyses and recent activities, providing a comprehensive outlook of global nanotechnology industry. Overall, the report provides all the pre-requisite information for clients looking to venture in this industry, and facilitate them to formulate schemes while going for an investment/partnership in the industry.

Key Topics Covered:

1. Analyst View

2. Research Methodology

3. Nanotechnology - An Introduction

4. Key Market Trends and Developments 4.1 Nanotech Tools Open Market for more Miniature Electronics 4.2 Nanotechnology Accelerating Healthcare and Medical Device Industry 4.3 International Collaborations for Nanotechnology Research 4.4 Nanotechnology Playing a Vital Role in the Growth of Energy Industry 4.5 Nanotechnology Playing a Key Role in the Growth of Food & Agriculture Industry

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5. Nanotechnology Market Outlook to 2024 5.1 By Components 5.1.1 Nanomaterials 5.1.2 Nanotools 5.1.3 Nanodevices 5.2 By Major Applications 5.2.1 Electronics 5.2.1.1 Nanocircuits 5.2.1.2 Nanowires 5.2.1.3 NanoSensors 5.2.2 Energy 5.2.2.1 Energy Source 5.2.2.2 Energy Conversion 5.2.2.3 Energy Storage 5.2.2.4 Energy Distribution 5.2.2.5 Energy Usage 5.2.3 Cosmetics 5.2.3.1 Skin Care 5.2.3.2 Hair Care 5.2.4 Biomedical 5.2.4.1 Drug Delivery 5.2.4.2 Therapeutics 5.2.4.3 Medical Materials and Implants 5.2.4.4 Analytical Tools and Instruments 5.2.4.5 Diagnostics 5.2.5 Defense 5.2.5.1 Military Vehicles 5.2.5.2 Military Clothes 5.2.5.3 Aeronautics 5.2.5.4 Satellites 5.2.6 Food and Agriculture 5.2.6.1 Agriculture & Food Processing 5.2.6.2 Food Packaging 5.2.6.3 Food Supplements

6. Country-Level Analysis

7. Patents Analysis

8. Competitive Landscape

- Ablynx - Acusphere, Inc. - Advanced Diamond Technologies, Inc. - Altair Nanotechnologies Inc. - Bruker Nano GmbH - Nanophase Technologies Corporation - Nanosys, Inc. - PEN, Inc - SouthWest NanoTechnologies, Inc. - Unidym, Inc. - Zyvex Corporation

For more information about this report visit http://www.researchandmarkets.com/research/q4s4zs/global

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Laura Wood, Senior Manager press@researchandmarkets.com

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Global Nanotechnology Market Outlook 2016-2024 Featuring Altair ... - Yahoo Finance

Renowned chemical engineer and nanomedicine pioneer joining USC – USC News

Mark E. Davis, a renowned chemical engineering professor and nanomedicine pioneer at Caltech, will join the USC faculty in October. His work on biomaterials for cancer treatment holds great promise to make medicines more targeted and effective.

Davis, one of the few academics selected to the National Academy of Engineering (1997), the National Academy of Sciences (2006) and the National Academy of Medicine (2011), will hold a Provost Professor appointment at USC, with a primary academic home in the Mork Family Department of Chemical Engineering at the USC Viterbi School of Engineering. He will be based at the University Park Campus, the soon to open Michelson Center for Convergent Bioscience and the Health Sciences Campus.

In addition to his USC Viterbi appointment, Davis also will hold joint appointments in the Department of Preventive Medicine at the Keck School of Medicine of USC, as well as the Department of Chemistry at the USC Dornsife College of Letters, Arts and Sciences.

Davis research efforts involve materials synthesis in two general areas: zeolites and other solids that can be used for molecular recognition and catalysis, and polymers for the delivery of a broad range of therapeutics. He also conducts pioneering work on engineering nanoparticles for cancer therapeutics.

During his time at Virginia Polytechnic Institute & State University (Virginia Tech) from 1981 to 1991, Davis and his research team invented a number of new zeolites and molecular sieves. They were the first to report the synthesis of a molecular sieve with uniform pore sizes larger than 1 nanometer. In recognition of his work, Davis became the first engineer to receive the National Science Foundations Alan T. Waterman Award in 1990.

While at Caltech in 1995, Davis expanded the focus of his research to biomaterials for cancer research. He did so in response to his wifes long and painful but ultimately successful fight against breast cancer.

Davis and his team became the first researchers to successfully engineer nanoparticles made from polymeric materials specifically designed and created for human cancer therapeutics. To date, three different nanoparticles invented by his lab have gone to numerous human, cancer clinical trials that have been and are being conducted both in the United States and throughout the world.

At USC, Davis will continue his groundbreaking work on engineering nanoparticles that can deliver drugs to the brain, research that began in recent years and could improve the treatment of brain cancer, Parkinsons and Alzheimers diseases, among other conditions. At Caltech, he and his team discovered how to successfully design nanoparticles that safely cross the blood-brain barrier in rodent models. Their work continues on the pathway to clinical translation of these nanoparticles that, if successful, would be a major medical breakthrough.

Davis will also serve as a strategic adviser to the deans of USC Viterbi and USC Dornsife, and will mentor faculty and students on convergent bioscience and engineering. As part of his duties at the Keck School of Medicine, Davis will serve as co-director of the MD/PhD program.

The connection between engineering and medicine is really a focal point for me, Davis said. At USC, I will work on trying to be a conduit to help people do translational medicine, especially in the area of therapeutics.

Mark Davis is a stellar addition to our faculty, said Provost Michael Quick. His multidisciplinary scholarship and research is an asset to the USC Michelson Center for Convergent Bioscience, where we are building bridges across our campus to transform medicine and science. I know he will help move us forward in these efforts. We are looking forward to his expertise and guidance.

USC Viterbi Dean Yannis C. Yortsos said: We are truly excited to have such a superb engineer and scientist as Mark Davis join USC. We are eagerly looking forward to his leadership in advancing the rapidly accelerating convergence between engineering and medicine.

Rohit Varma, dean of the Keck School and director of the USC Gayle and Edward Roski Eye Institute, added, We are delighted to welcome Mark to the Keck School family.

He will be a tremendous resource for our MD-PhD program. His visionary work that converges the disciplines of technology and health/medicine will inspire our students to innovate and create at the forefront of translational science.

USC Dornsife Dean Amber D. Miller said: USC Dornsife extends a warm welcome toProvost Professor Davis. We greatly benefit from his strong record of leadership, innovation and expertise in creating synergies across scientific fields.

Davis has written more than 425 scientific publications, two textbooks and holds 75 U.S. patents. He is a founding editor of CaTTech and a former associate editor of Chemistry of Materials and the AIChE Journal, published by the American Institute of Chemical Engineers.

Over the decades, Davis has won a raft of awards, including the Colburn and Professional Progress awards from the AIChE and the Somorjai, Ipatieff, Langmuir, Murphree and Gaden prizes from the American Chemical Society. In 2014, he received the Prince of Asturias Award for Technical and Scientific Research from the King of Spain, and in 2015, he was elected to the National Academy of Inventors.

A scientist with an entrepreneurial bent, Davis founded Calando Pharmaceuticals Inc., a company that created the first RNAi therapeutic to reach the clinic for treating cancer, and Avidity Bioscience.

Apart from his scientific achievements, Davis attained All American Status for Masters Track and Field in the 400-, 200- and 100-meter dashes. In 2011, he won the 400-meter dash for men of age 55-59 at the Masters World Championship.

He holds three degrees from the University of Kentucky, all in chemical engineering.

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Valery Fokin will join the schools top scientists as USC aims to be among the worlds top institutions for convergent biomedical research.

Lyssa Arudas childhood passion leads to active engagement at USC Viterbi.

Mark Thompson and Karl Christe are slated to accept American Chemical Society awards in 2015.

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Renowned chemical engineer and nanomedicine pioneer joining USC - USC News

Nanomedicine: A Vast Horizon on a Molecular Landscape – Part VIII, Magnetic Nanoparticles theranostics – Lexology (registration)

This is the eighth article in a review series on Nanomedicine. We started from reviewing the major research and entrepreneurial development of nanomedicine and the relevant patent landscape (Part I and Part II). The first topic we discussed was Organs-on-a-chip (Part III). Following that, we focused on nanotechnology in medical therapeutics. Nanoparticles have nanoscale dimensions and demonstrate unique chemical and physical properties from their bulk. This also gives them great advantages in drug delivery (Part IV), cancer therapeutics (Part V), and bio-imaging (Part VI). In the last installment, we reviewed one special type of nanoparticles: quantum dots, which are incredibly small semiconductor particles (Part VII). Here, we will review the theranostic applications and IP landscape of another special type of nanoparticles known as magnetic nanoparticles (MNP). As in the past, those patent documents cited in the article are summarized in the table at the end.

Magnetic Nanoparticles Magnetic nanoparticles, also known as superparamagnetic nanoparticles are small inorganic crystals about 5-20 nm in diameter. Two main classes of MNPs currently used for clinical imaging are ferromagnetic iron oxide nanoparticles and ultrasmall superparameganetic iron oxide nanoparticles (USPION). MNPs are usually multilayer materials, which give them their various properties and functionalities for diagnosis and disease treatment. The structure of iron oxide nanoparticles has three main components: an iron oxide core as a Magnetic Resonance Imaging (MRI) contrast agent, a biocompatible coating outside the core, and an outer therapeutic coating with specific ligands for biomarker targeting. See (US 8,945,628 by Dr. Ralph Weissleder at Massachusetts General Hospital and US 7,462,446 by Dr. Miqin Zhang at the University of Washington). This unique structure enables MNP accumulation in the sites of interest via biomarker targeting. It further allows the diagnosis of diseases, the evaluation of treatment efficacy, and the localized delivery of drugs and disease therapies. The integration of both diagnostic and therapeutic modalities into one single agent is called a theranostic agent. We will discuss the diagnostic and therapeutic properties of MNPs in cancer.

Magnetic Nanoparticles for Diagnosis In 2008, the International Agency for Research on Cancer reported that the total number of cancer case around the world doubled between 1975 and 2000, and that the number of cases are expected to triple by 2030. This means there will be 13-17 million cancer deaths annually by that time. The only chance for successful treatment of cancer is early cancer diagnosis, by identifying the cancer before the patient shows symptoms. Currently the standard cancer detection technology in the clinic is imaging, such as positron emission tomography (PET) and Magnetic Resonance Imaging (MRI). Dr. Ralph Weissleder at Massachusetts General Hospital (MGH) is a pioneer in the field of clinical imaging using advanced nanomaterials (US 6,615,063, US 8,569,078 and US 9,097,644). He predicted that high resolution molecular imaging technologies (including those utilizing nanoparticles) can screen tumor growth at very early stages.

Currently, there are two main nanoimaging technologies, fluorescence imaging and MRI. In fluorescence imaging, quantum dots can target malignant tissues and show strong localized signals (Part VI). Magnetic nanoparticles demonstrate advanced applications in MRI. MRI is a non-invasive medical imaging technology based on nuclear magnetic resonance. When the magnetic field around the nuclei varies, the nuclei relax their magnetic moment through spin-lattice relaxation and spin-spin relaxation. With the assistance of MRI contrast agents, the MRI captures the change of relaxation times of protons around tissues and forms the medical images. Iron oxide magnetic nanoparticles are one of the currently used contrast agents for MRI. These particles can shorten the spin-lattice relaxation time T1 (brighter signal) and the spin-spin relaxation time T2 (darker signal), forming a sharper and brighter image. These particles can also be actively targeted or passively targeted to malignant sites to differentiate between normal and diseased tissues.

MNPs are the most advanced contrast labels currently being used in research and development for medical imaging. Dr. Shan Wangs group at Stanford University has developed superparameganetic iron oxide nanoparticles (SPIONs) and fluorescent tag conjugated SPIONs for biological molecular imaging (US 7,682,838 and US 8,722,017 ). Dr. Miqin Zhangs group at the University of Washington has developed MNPs with a Fe3O4 core and a mesoporous silica shell embedded with carbon dots and paclitaxel (a common anti-cancer drug), and covered by another layer of silica. These MNPs enable confocal and twophoton fluorescence imaging via carbon dots and MRI via magnetic Fe3O4. They also deliver the paclitaxel to cancer cells to kill them through combined photothermal and chemotherapy. Dr. Zhang also developed major histocompatibility complex (MHC) conjugated MNPs for imaging T cells and also chitosan-polyethylene oxide oligomer copolymer coated MNPs for brain tumor imaging and drug delivery (US 20160193369, US 20150320890, and US 20140286872). Dr. Koichiro Hayashi demonstrated the advantages of using SPIONs for cancer theranostics by combining MRI and magnetic hyperthermia treatment (WO/2012/026194). His team modified the SPION clusters with folic acid and polyethylene glycol (PEG) to promote the accumulation of clusters in tumors. Dr. Qun Zhao at the University of Georgia developed hyperthermia treatment of head and neck cancers in a mouse model via intratumor injection of SPIONs. Ultrasmall superparamagnetic iron oxide nanoparticles (USPIONs) having smaller size in diameter, resulting in longer circulation time. These particles can accumulate in the microvascularture before being endocytosed (i.e. removed) by macrophages. Therefore, these particles can be used for tumor-associated microvessel imaging. Dr. Edward Neuwelt reported clinical data with enhanced brain tumor imaging by USPIONs. Other groups from France and Switzerland also reported similar results.

Summary Magnetic nanoparticles are not only used as MRI contrast labels for medical imaging, but also used as therapeutic drug delivery carriers, as hyperthermia tools, and even as combined drug delivery and imaging agents for cancer therapy. In the next installment, we will discuss further details on the application of these particles in cancer therapeutics.

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Careers, technology on display at manufacturing show – Chippewa Herald

Cole Hill knows what he wants to do in a future career. I want to build motors V-8s probably, said the Colfax High School junior who spends time racing at the Red Cedar and Jim Falls tracks.

But just what does one study to prepare to build big engines? Hunter Sullivan of Chippewa Falls, a Chippewa Valley Technical College Machine Tooling Technics student, had some ideas for him at CVTCs annual Manufacturing Show Thursday, March 2.

He told me about their CNC (computerized numerical control) machines and the careers, said Hill, who thinks he will eventually enroll at CVTC, but he is unsure of which program. I havent looked at any other places.

Introducing people like Hill to careers in manufacturing is a big part of CVTCs Manufacturing Show, which drew about 1,600 people to CVTCs Manufacturing Education Center. Wonders of modern manufacturing were displayed and demonstrated in CVTCs Automation Engineering Technology, Industrial Mechanical, Machine Tooling Technics and Welding/Welding Fabrication, as well as Manufacturing, Nano and Industrial Engineering programs.

About 40 manufacturing companies were also represented with display tables highlighting their products and job opportunities.

Sullivan, a 2015 Chippewa Falls Senior High School graduate, connected with Hill as another young man who likes to work with his hands. I just like making things, Sullivan said. I took shop classes in high school with manual lathes and I thought that was pretty cool. But what I learn here is way more than they teach you in high school.

Sullivan is already working in manufacturing, doing some part-time laser cutting work at Riverside Machine. Im not doing CNC work, but hopefully when I finish school they will keep me on as a machinist, he said.

Visitors at the Manufacturing Show were able to take part in hands-on activities like trying their hand at welding, building a tiny flashlight with the help of Manufacturing Engineering Technologist students, or playing with projects like a billiards game made by Automation Engineering Technology students.

This is an opportunity to show off new technology, said CVTC Dean of Manufacturing Jeff Sullivan. The Manufacturing Show brings together alumni and people in the area, and shows off student projects. Our manufacturing partners come in and show the things theyre doing.

Several area high schools sent busloads of students who also toured some area manufacturing companies prior to the show. Other high school students came on their own, or with their parents.

Tim Frank of Menomonie, a CVTC graduate himself, came with his wife and son, Nathan. Hes interested in coming here next year, Frank said. Hes working at a machine shop in Menomonie after school now. He saw this show was available and asked to come.

I really havent decided what program to take, Nathan said. But it will probably be something in the machining area. Its making stuff. Its hands-on.

Dawn Schrankler and her husband brought their daughter, Kelsey, from Neillsville for the show. Were trying to get her interested in more of a selection, said Schrankler. She wants to be a veterinarian assistant, but were trying to broaden her horizons and open her eyes to other areas.

But not all of the people attending the show to explore careers were high school students or even recent high school graduates. People looking for a change of careers found plenty of older CVTC students who followed a similar path.

This program is fantastic, said Casey Schellhorn, an Automation Engineering Technology student who graduated from River Falls High School back in 2010. I wanted more opportunity than I had working in food service. I was looking for something interesting and found this on the CVTC website.

Schellhorn was stationed where he could explain to visitors how to play a miniature billiards game and also the pneumatics, electronics and sensors that made the game work. In all the program areas, other students were present to explain what they do, what they are learning, and the exciting opportunities available to them in manufacturing careers.

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Associate chemical engineering professor recognized by The Welch Foundation – UT The Daily Texan

The Welch Foundation, one of the largest funding resources for chemical research, recognized associate professor Delia Milliron for her contribution to controlling sunlight from entering buildings, according to the foundations website.

Last Wednesday, The Welch Foundation announced Milliron as one of the two recipients of the 2017 Norman Hackerman Award in Chemical Research. The award was established to honor Norman Hackerman, the foundations scientific advisory board member, with the purpose of supporting Texas scientists who are dedicated to increasing the fundamental understanding of chemistry.

Milliron said it is a great honor to be recognized by The Welch Foundation, and she is very proud to receive this award.

(The Welch Foundation is) a very important supporter of chemistry across the state of Texas, and they found some of the research in my lab and in many others across campus and around the state, Milliron said over the phone. Its a really important driver of innovation in Texas to have the Welch foundation supporting us with grants and with awards like this one.

Milliron is also an associate editor of Nano Letters, a journal of the American Chemical Society, which includes publications related to nanomaterial chemistry.

Thomas Truskett, chair of the McKetta Department of Chemical Engineering, said Milliron is a rising star in the chemical sciences, and she is well-deserved of the award.

The Hackerman Award is a fiercely competitive prize, Truskett said in an email. The fact that Dr. Milliron was chosen for it this year, as well as another colleague from our Department last year, points toward the excellence of our young faculty, who represent the future of the Department.

The Welch Foundation is based in Houston and has contributed to the advancement of chemistry by supporting institutions in Texas with research grants and special projects, according to the foundations website.

Chemistry freshman Andrea Torres said its inspiring to see Millirons recogniton, because she represents a strong female leader in the scientific community.

For a long time chemistry and sciences in general were predominantly male, and to have a woman win an award like that its a pretty big deal, Torres said. It shows that we have a program thatpushes innovation.

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Associate chemical engineering professor recognized by The Welch Foundation - UT The Daily Texan

Moore’s Law can’t last foreverbut two small changes might mean your phone battery will – Quartz


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Moore's Law can't last foreverbut two small changes might mean your phone battery will
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Moore's theory was that the power of computers would double every 12 months while the cost of that technology would fall by 50% over the same time. And so, for 40 years, what became known as Moore's Law remained pretty rock-solid. But these are hard ...
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Moore's Law can't last foreverbut two small changes might mean your phone battery will - Quartz

Department of Defense Impact Award Funds Prostate Cancer Study – Cornell Chronicle

Weill Cornell Medicine researchers will receive a grant from the Department of Defense to conduct an in-depth study of the molecular machinery driving the most aggressive form of prostate cancer.

Most prostate cancers are a type called adenocarcinoma, which is regulated by the male hormone androgen. Advanced adenocarcinoma of the prostate is typically treated with drugs that cut off the supply of that hormone. Increasingly, however, these cancers are becoming resistant to androgen-blocking treatment and progressing to a more aggressive form of the disease, called neuroendocrine prostate cancer.

The grant, an Impact Award from the Department of Defense, will provide the Weill Cornell Medicine research team with three years of funding to identify patients who are at risk of developing neuroendocrine prostate cancer, and to advance early treatment strategies to prevent that progression. The Department of Defense offers the Impact Award as part of its Prostate Cancer Research Program, which is dedicated to advancing scientific understanding of the disease with the goal of improving health outcomes.

The neuroendocrine type of prostate cancer is associated with distinct molecular features, said Dr. David Rickman, an assistant professor of pathology and laboratory medicine at Weill Cornell Medicine and co-principal investigator of the Impact Award. Understanding how it develops is critical for developing new treatment strategies.

Dr. Rickman and Dr. Himisha Beltran, an assistant professor of medicine at Weill Cornell Medicine and co-principal investigator of the Impact Award, will focus on one pathway, driven by a gene called N-Myc, which they have previously identified as a key driver of this cancer. Through earlier research in mice, the investigators discovered that prostate adenocarcinoma progresses to neuroendocrine prostate cancer when N-Myc is overactive. N-Myc also recruits a protein called EZH2 to help it activate the molecular machinery that causes this progression.

The investigators, both of whom are members of the Sandra and Edward Meyer Cancer Center and the Caryl and Israel Englander Institute for Precision Medicine at Weill Cornell Medicine, will employ clinical and preclinical approaches to their work: Dr. Beltrans research will focus on using tumor samples from patients to identify how and when N-Myc drives the cancer and the diseases response to treatment. Dr. Rickman will create a mouse model to better understand how N-Myc works and to test new treatment options. It is team science, Dr. Beltran said. We will work together to better understand the pathogenesis and molecular biology of neuroendocrine prostate cancer by integrating preclinical modeling with patients clinical and molecular features.

At the end of three years, the researchers hope to have developed innovative treatment strategies that can be applied directly to patients. There are several unanswered questions about this cancer, Dr. Beltran said. We hope to get some answers that can help patients.

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Department of Defense Impact Award Funds Prostate Cancer Study - Cornell Chronicle