Opinion: A libertarian explains why Trump’s new travel ban is still legally suspect – MarketWatch

President Trump issued a new executive order this week that revises, rescinds, and replaces his prior order banning immigration from several majority-Muslim countries. The new order, which is scheduled to taked effect on March 16, is supposed to bolster the White Houses case in court, resolving legal defects that prevented the ban from prevailing the first time around.

In some ways, it accomplishes its goal, but in other ways, the new order undermines several legal arguments that the administration has been making.

While defending the president against a lawsuit brought by the state of Washington, the administrations attorneys justified his list of seven majority-Muslim countries by stating that they were previously identified as posing a heightened risk of terrorism by Congress or the Executive Branch. In fact, they said, Congress itself identified Iraq and Syria as countries of concern.

This argument was always weak because, although Congress did single out these countries for additional vetting, it still specifically provided for the ability of Iraqi and Syrian nationals to come to America so long as they had a visa. But now the president has excluded Iraq from the list, which means its justification that this list was something Congress put together is gone.

The whole point of the ban, as the administration put it, was to establish adequate standards to prevent infiltration by foreign terrorists. In other words, because the vetting process is inadequate, and these nationalities are (in the eyes of the administration) inherently dangerous, people from the selected countries cannot be allowed in.

The new order exempts current visa holders from these countries. But this change totally undermines the argument that these nationals are dangerous even if they are screened. By fixing one problem, the administration creates another one for itself. If these nationals are dangerous, why would it concede to allow any of them in?

Heres a more immediate concern for the administration. When the original order was challenged, the administration argued in court that any delay in implementation immediately harms the public by thwarting enforcement of an Executive Order issued by the President, based on his national security judgment. It is likely that they will argue the same when this one is challenged.

President Trump signed a new executive order on immigration Monday that revised his first one halted by the courts. Here's a look at what is different about this new order and whether it will face the same legal issues. Photo: Getty

Yet the new order delays the effective date for more than a week. It does so to resolve a potential legal concern tied to banning people without notice. But the delay effectively eviscerates the argument from the presidents legal team that a judges decision to suspend enforcement of it would impose irreparable harm. A judge could respond, If thats true, did the presidents delay also harm the United States?

The administration also claimed that this was not a ban intended to reduce admissions of immigrants from these majority Muslim countries. Instead, it was just a temporary 90-day pause on entries from these places to allow the government to review vetting procedures. But now the new order restarts this timeline.

Why would the clock on reviewing procedures stop ticking just because the old order wasnt blocking entries? This provides evidence that these timelines were in fact arbitrary and that the goal wasnt about giving the administration time to review, but rather about cutting legal immigration of peoplemainly Muslim immigrantsthat the administration simply does not like.

Despite all of the changes, the fundamental problems persist. The order still references 1952 law providing that the president can exclude any class of alien if he finds them detrimental. But this justification ignores a later-enacted 1965 law that bans discrimination against immigrant visa applicants based on nationality. While the 1965 law provides a list of exceptions, the 1952 law was specifically not included among them.

Congress did not want to allow the president this authority. In fact, it specifically debated the question of whether difficult-to-screen countries should be included under the 1965 non-discrimination rule and decided that they should be.

This means that the executive order re-boot is still legally suspect. Indeed, in some ways, because it undermines so many of the governments arguments, the order has become even more suspect than it was before, and the courts should tell the president to go back to the drawing board once again.

David J. Bier is an immigration policy analyst at the libertarian Cato Institutes Center for Global Liberty and Prosperity.

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Opinion: A libertarian explains why Trump's new travel ban is still legally suspect - MarketWatch

Solomon Islands police to be rearmed ahead of RAMSI withdrawal – ABC Online

Updated March 09, 2017 20:37:31

Nearly two decades after ethnic violence gripped the Solomon Islands and the country's police force failed to maintain law and order, the government is approving the rearmament of the small number of police officers.

The Commissioner of the Royal Solomon Islands Police Force Matthew Varley said officers with the police response team and close personal protection team would soon be armed.

"These are the officers that provide ready response to high risk situations and also provide protection to our dignitaries and foreign officials," he said.

"Those are the only areas to be rearmed under this program. By and large the remainder of the Solomon Islands police force remains unarmed."

Rearmament became a sensitive subject in Solomon Islands after the police force's impartiality broke down during the five-year period of ethnic violence known as The Tensions.

Some officers became participants in the conflict.

The police armoury in the capital Honiara was raided and the stolen weapons fuelled the fighting.

An Australian-donated police patrol boat was even used to strafe villages with machine gun fire.

Commissioner Varley acknowledged there was still unease in the community at the prospect of police having access to firearms again.

"History shows Solomon Islands people are quite concerned about this program and are watching us closely," he said.

"We're mindful of some of the tensions that occurred many years ago when former police weapons were actually stolen and misused and for that reason the rearmament is quite limited in its scope."

In 2003 the Australian-led Regional Assistance Mission to Solomon Islands, RAMSI, arrived to restore peace and rebuild the country.

RAMSI is withdrawing in the middle of the year and the 100 foreign police officers that are currently in the country will also depart.

The head of RAMSI, special coordinator Quentin Devlin, said the limited rearmament of the police would be a significant milestone in the country's recovery from The Tensions.

"I think the staged and limited rearmament of the Royal Solomon Islands Police Force is the last major piece in the rebuilding of the police force before RAMSI can leave," he said.

RAMSI and the police have been holding information sessions in villages, schools, markets and businesses to explain why the assistance mission is leaving and why the police force is being rearmed.

Mr Devlin said he was often asked by people whether they could trust the police, and he told them yes, they can.

"We point to a range of different things including the strong leadership of the RSIPF, its performance over a number of years now, its strong performance on crime prevention and police discipline and also that the government's been increasing the resources of the RSIPF over the last couple of years," he said.

Josephine Teakini from the women's group Vois Blong Mere said the conduct of police during The Tensions was still fresh in people's minds despite the passage of time.

"When the tension happened in Solomon Islands the force was also being part of the shootings that were happening. The neutrality of the police force at the time was in question," she said.

Ms Teakini said while some people were comfortable with the limited rearmament, most would be very concerned if more officers were to be armed.

"What if there's another tension or something similar to that, what's going to happen? Will the arms be taken up again and used against community people instead of protecting?" she asked.

Commissioner Varley is trying to reassure people the police force has changed significantly.

"More than two thirds of the RSIPF has been recruited since the tension period," he said.

"We've had heavy investment in training by RAMSI and development over that time.

"The officers that are involved in this limited rearmament program have been trained to the highest standards and I'm pretty confident that those officers are well disciplined and ready to take on that extra responsibility."

Topics: police, defence-and-national-security, solomon-islands, asia, pacific

First posted March 09, 2017 20:08:24

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8×8 Bridges Messaging Islands – No Jitter

8x8 Bridges Messaging Islands As part of an 'open cloud' initiative, 8x8 picks up Sameroom.io for its ability to provide interoperability among disparate team messaging services.

As part of an 'open cloud' initiative, 8x8 picks up Sameroom.io for its ability to provide interoperability among disparate team messaging services.

8x8 today made several announcements that reflect a broad vision for cloud communications services. The announcements fall into three categories: integration, a messaging acquisition, and APIs.

8x8 is offering an increased number of pre-integrated, supported cloud services. These include the usual suspects of popular business applications such as Salesforce and SAP, but what's unique -- and surprising -- is a number of integrations with messaging-based services such as Slack, Cisco Spark, and Microsoft Teams.

Yes, 8x8 is offering messaging interoperability with several services that don't necessarily integrate with other services. This it has accomplished via Sameroom.io, a workstream messaging interoperability service in use by more than 200 organizations. It gained Sameroom in the acquisition of its parent company, LeChat, last quarter for an undisclosed price.

Defragmenting Team Collaboration Sameroom.io before, and 8x8 now, addresses the challenge of fragmented communication caused by messaging islands. Teams continue to select tools and services that work best for them, not necessarily what works best for the enterprise. Messaging services are proliferating like ants at a picnic -- faster than IT can contain them.

Consider the messaging solutions from Microsoft alone, which include Yammer, Skype, Skype for Business, Outlook, Outlook Groups, Teams, and GroupMe. That's a lot of choices with little or no interoperability from just one vendor. Factor in other common services such as Atlassian HipChat, Slack, Cisco Spark, and Google Hangouts. All of these services fragment communications, which creates compliance and data control challenges for enterprises.

IT commonly deals with this problem by decreeing which apps can and can't be used, but that's an uphill battle that fuels shadow IT. Nor does a single app solution address the collaboration challenges between teams that span across multiple organizations. Another approach is to use Sameroom.io to allow teams to choose their own tools, yet still communicate and collaborate with each other.

Many believe that workstream messaging applications can potentially replace email, save for constraints due to interoperability limitations. Email and telephony are so powerful because they span across vendors, companies, and countries. Email works regardless of the user's solution: Exchange/Outlook, G Suite, IBM Verse, etc. "Entropy is the primary growth driver for Sameroom," says Andrei Soroker, Sameroom founder and now 8x8's director of product strategy for Sameroom.

What's particularly noteworthy is that 8x8 is not launching its own workstream messaging solution. Instead, it has unspecified intent to expand its existing instant messaging service with additional capabilities, and said that it will direct customers with more advanced requirements to existing services such as Slack.

This is a highly differentiated approach within UCaaS. Most providers are introducing new workstream messaging solutions, in essence creating new islands. They are not addressing interoperability or evolving current IM services.

Open Cloud The final set of announcements relate to 8x8's new open cloud initiative. Open cloud provides expanded and rich APIs and scripting tools to allow customers to personalize and customize their hosted PBX experiences -- in real time. It effectively brings the CPaaS era back to the PBX.

The APIs fall into four broad categories: communication microservices, provisioning and service management, analytics and data extraction, and dynamic communications flow and routing. The APIs are complemented with Script8 -- 8x8's internal scripting tool now available to customers. These tools expose 8x8's core switching solution to programmatic control.

For example, customers can integrate other applications to directly interact with the PBX. A CRM record can dynamically impact call routing to get a specific person to a specific agent, or new extensions can be created for employees as they are onboarded in HR. Business intelligence systems can directly integrate with 8x8 raw usage data. 8x8 is also providing customers access to customizable scripts including two-factor authentication, store locator, and emergency broadcast.

8x8 describes its expanded service as the first "communications cloud" built on the pillars of UC, contact center, video, analytics, APIs, and interoperability. 8x8 intends to differentiate with simultaneous strategies for rich communications services with coupled platform services for customization and integration to facilitate a comprehensive communications strategy.

These announcements indicate that 8x8 remains highly focused on UCaaS as its core and is not chasing new segments with me-too services. Instead, 8x8 intends to strengthen its core hosted services with integration, APIs, and enhanced control.

Dave Michels is a contributing editor and analyst at TalkingPointz.

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8x8 Bridges Messaging Islands - No Jitter

9 Caribbean Islands You Should Visit Right Now – Caribbean Journal

Whether youre searching for a culinary retreat or a luxe getaway, nows as good a time as any to come to the Caribbean for whatever kind of trip youre looking for.

Because the Caribbean just keeps getting better, with an increasingly diverse tourism product and more and more high-quality travel offerings from gastronomy to culture to throwback luxury.

As always, though, youre probably searching for something new.

And we have you covered, with some new faces and established places that are worth a new look.

Here are nineislands to visit this spring.

Greenwood Beach on Cat Island.

Cat Island

This sparsely-populated Bahamian island is perhaps most famous as the childhood home of Sidney Poitier. But it should be on your radar for far more, from some of the Caribbeans greatest untouched beaches to world-class kitesurfing to some classic tiny beach resorts. Simply put, there arent many places like this left, in the Caribbean or otherwise. And thats a magnificent reason to go.

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9 Caribbean Islands You Should Visit Right Now - Caribbean Journal

What does it mean to be human? – The Independent

The Rock of Gibraltar appears out of the plane window as an immense limestone monolith sharply rearing up from the base of Spain into the Mediterranean. One of the ancient Pillars of Hercules, it marked the end of the Earth in classical times. Greek sailors didnt go past it. Atlantis, the unknown, lay beyond.

In summer 2016, Gibraltar is in the throes of a 21st-century identity crisis: geographically a part of Spain, politically a part of Britain; now torn, post-Brexit, between its colonial and European Union ties. For such a small area less than seven square kilometres Gibraltar is home to an extraordinarily diverse human population. It has been home to people of all types over the millennia, including early Europeans at the edge of their world, Phoenicians seeking spiritual support before venturing into the Atlantic, and Carthaginians arriving in a new world from Africa.

But Ive come to see who was living here even further back, between 30,000 and 40,000 years ago, when sea levels were much lower and the climate was swinging in and out of ice ages. It was a tough time to be alive and the period saw the species that could, such as birds, migrate south to warmer climes, amid plenty of local extinctions. Among the large mammal species struggling to survive were lions, wolves and at least two types of human: our own modern human ancestors, and the last remaining populations of our cousins, the Neanderthals.

By understanding more about these prehistoric people, we can learn about who we are as a species today. Our ancestors experiences shaped us, and they may still hold answers to some of our current health problems, from diabetes to depression.

Im picked up outside my hotel by archaeologists Clive and Geraldine Finlayson, in a car that itself looks fairly ancient. Typical for this crowded little peninsula, they are of diverse origins he, pale-skinned and sandy-haired, can trace his ancestry back to Scotland; she, olive-skinned and dark-haired, from the Genoese refugees escaping Napoleons purges. How different we humans can look from each other. And yet the people whose home I am about to visit truly were of a different race.

We dont know how many species of humans there have been, how many different races of people, but the evidence suggests that around 600,000 years ago one species emerged in Africa that used fire, made simple tools from stones and animal bones, and hunted big animals in large cooperative groups. And 500,000 years ago, these humans, known as Homo heidelbergensis, began to take advantage of fluctuating climate changes that regularly greened the African continent, and spread into Europe and beyond.

The use of tools could be part of a wider breadth of survival adaptations, including resistance to plague and HIV ( Tom Sewell)

By 300,000 years ago, though, migration into Europe had stopped, perhaps because a severe ice age had created an impenetrable desert across the Sahara, sealing off the Africans from the other tribes. This geographic separation enabled genetic differences to evolve, eventually resulting in different races, although they were still the same species and would prove able to have fertile offspring together. The race left behind in Africa would become Homo sapiens sapiens, or modern humans; those who evolved adaptations to the cooler European north would become Neanderthals, Denisovans and others whom we can now only get a glimpse of with genetics.

Neanderthals were thriving from Siberia to southern Spain by the time a few families of modern humans made it out of Africa around 60,000 years ago. These Africans encountered Neanderthals and, on several occasions, had children with them. We know this because human DNA has been found in the genomes of Neanderthals, and because everyone alive today of European descent including me has some Neanderthal DNA in their genetic makeup. Could it be that their genes, adapted to the northerly environment, provided a selective advantage to our ancestors as well?

After driving through narrow tunnels on a road that skirts the cliff face, we pull up at a military checkpoint. Clive shows the guard our accreditation and were waved through to park inside. Safety helmets on to protect from rockslides, we leave the car and continue on foot under a low rock arch. A series of metal steps leads steeply down the cliff to a narrow shingle beach, 60 metres below. The tide is lapping the pebbles and our feet must negotiate the unstable larger rocks to find a dry path.

Ive been concentrating so hard on keeping my footing that it is something of a shock to look up and suddenly face a gaping absence in the rock wall. We have reached Gorhams Cave, a great teardrop-shaped cavern that disappears into the white cliff face and, upon entering, seems to grow in height and space. This vast, cathedral-like structure, with a roof that soars high into the interior, was used by Neanderthals for tens of thousands of years. Scientists believe it was their last refuge. When Neanderthals disappeared from here, some 32,000 years ago, we became the sole inheritors of our continent.

I pause, perched on a rock inside the entrance, in order to consider this people not so different from myself once sat here, facing the Mediterranean and Africa beyond. Before I arrived in Gibraltar, I used a commercial genome-testing service to analyse my ancestry. From the vial of saliva I sent them, they determined that 1 per cent of my DNA is Neanderthal. I dont know what health advantages or risks these genes have given me testing companies are no longer allowed to provide this level of detail but it is an extraordinary experience to be so close to the intelligent, resourceful people who bequeathed me some of their genes. Sitting in this ancient home, knowing none of them survived to today, is a poignant reminder of how vulnerable we are it could so easily have been a Neanderthal woman sitting here wondering about her extinct human cousins.

Gorhams Cave seems an oddly inaccessible place for a home. But Clive, who has been meticulously exploring the cave for 25 years, explains that the view was very different back then. With the sea levels so much lower, vast hunting plains stretched far out to sea, letting people higher on the rock spot prey and signal to each other. In front of me would have been fields of grassy dunes and lakes wetlands that were home to birds, grazing deer and other animals. Further around the peninsula to my right, where the dunes gave way to shoreline, would have been clam colonies and mounds of flint. It was idyllic, Clive says. The line of neighbouring caves here probably had the highest concentration of Neanderthals living anywhere on Earth. It was like Neanderthal City, he adds.

Deep inside the cave, Clives team of archaeologists have found the remains of fires. Further back are chambers where the inhabitants could have slept protected from hyenas, lions, leopards and other predators. They ate shellfish, pine seeds, plants and olives. They hunted big game and also birds. There was plenty of fresh water from the springs that still exist under what is now seabed, Clive says. They had spare time to sit and think they werent just surviving.

Solid writing: Neanderthal engravings might be the first examples of text ( Tom Sewell)

He and Geraldine have uncovered remarkable evidence of Neanderthal culture in the cave, including the first example of Neanderthal artwork. The hashtag, a deliberately carved rock engraving, is possibly evidence of the first steps towards writing. Other signs of symbolic or ritualistic behaviour, such as the indication that Neanderthals were making and wearing black feather capes or headdresses as well as warm clothes, all point to a social life not so different to the one our African ancestors were experiencing.

Clive shows me a variety of worked stones, bone and antler. I pick up a flint blade and hold it in my hand, marvelling at how the same technology is being passed between people biologically and culturally linked but separated by tens of thousands of years. Other sites in Europe have uncovered Neanderthal-made necklaces of strung eagle talons dating back 130,000 years, little ochre clamshell compacts presumably for adornment, and burial sites for their dead.

These people evolved outside of Africa but clearly had advanced culture and the capability to survive in a hostile environment. Consider modern humans were in the Middle East perhaps 70,000 years ago, and reached Australia more than 50,000 years ago, says Clive. Why did it take them so much longer to reach Europe? I think it was because Neanderthals were doing very well and keeping modern humans out.

But by 39,000 years ago, Neanderthals were struggling. Genetically they had low diversity because of inbreeding and they were reduced to very low numbers, partly because an extreme and rapid change of climate was pushing them out of many of their former habitats. A lot of the forested areas they depended on were disappearing and, while they were intelligent enough to adapt their tools and technology, their bodies were unable to adapt to the hunting techniques required for the new climate and landscapes.

In parts of Europe, the landscape changed in a generation from thick forest to a plain without a single tree, Clive says. Our ancestors, who were used to hunting in bigger groups on the plains, could adapt easily: instead of wildebeest they had reindeer, but effectively the way of capturing them was the same. But Neanderthals were forest people.

It couldve gone the other way if instead the climate had got wetter and warmer, we might be Neanderthals today discussing the demise of modern humans.

Although the Neanderthals, like the Denisovans and other races we are yet to identify, died out, their genetic legacy lives on in people of European and Asian descent. Between 1 and 4 per cent of our DNA is of Neanderthal origins, but we dont all carry the same genes, so across the population around 20 per cent of the Neanderthal genome is still being passed on. Thats an extraordinary amount, leading researchers to suspect that Neanderthal genes must be advantageous for survival in Europe.

Interbreeding across different races of human would have helped accelerate the accumulation of useful genes for the environment, a process that would have taken much longer to occur through evolution by natural selection. Neanderthal tweaks to our immune system, for example, may have boosted our survival in new lands, just as we prime our immune system with travel vaccines today. Many of the genes are associated with keratin, the protein in skin and hair, including some that are linked to corns and others that play a role in pigmentation Neanderthals were redheads, apparently. Perhaps these visible variants were considered appealing by our ancestors and sexually selected for, or perhaps a tougher skin offered some advantage in the colder, darker European environment.

Some Neanderthal genes, however, appear to be a disadvantage, for instance making us more prone to diseases like Crohns, urinary tract disorders and type 2 diabetes, and to depression. Others change the way we metabolise fats, risking obesity, or even make us more likely to become addicted to smoking. None of these genes are a direct cause of these complicated conditions, but they are contributory risk factors, so how did they survive selection for a thousand generations?

Its likely that for much of the time since our sexual encounters with Neanderthals, these genes were useful. When we lived as hunter-gatherers, for example, or early farmers, we would have faced times of near starvation interspersed with periods of gorging. Genes that now pose a risk of diabetes may have helped us to cope with starvation, but our new lifestyles of continual gorging on plentiful, high-calorie food now reveal harmful side effects. Perhaps it is because of such latent disadvantages that Neanderthal DNA is very slowly now being deselected from the human genome.

While I can (sort of) blame my Neanderthal ancestry for everything from mood disorders to being greedy, another archaic human race passed on genes that help modern Melanesians, such as people in Papua New Guinea, survive different conditions. Around the time that the ancestors of modern Europeans and Asians were getting friendly with Neanderthals, the ancestors of Melanesians were having sex with Denisovans, about whom we know very little. Their surviving genes, however, may help modern-day Melanesians to live at altitude by changing the way their bodies react to low levels of oxygen. Some geneticists suspect that other, yet-to-be-discovered archaic races may have influenced the genes of other human populations across the world.

Interbreeding with Neanderthal and other archaic humans certainly changed our genes, but the story doesnt end there.

I am a Londoner, but Im a little darker than many Englishwomen because my father is originally from Eastern Europe. We are attuned to such slight differences in skin colour, face shape, hair and a host of other less obvious features encountered across different parts of the world. However, there has been no interbreeding with other human races for at least 32,000 years. Even though I look very different from a Han Chinese or Bantu person, we are actually remarkably similar genetically. There is far less genetic difference between any two humans than there is between two chimpanzees, for example.

The reason for our similarity is the population bottlenecks we faced as a species, during which our numbers dropped as low as a few hundred families and we came close to extinction. As a result, we are too homogeneous to have separated into different races. Nevertheless, variety has emerged through populations being separated geographically and culturally, in some cases over thousands of years. The greatest distinctions occur in isolated populations where small genetic and cultural changes become exaggerated, and there have been many of them over the 50,000 years since my ancestors made the journey out of Africa towards Europe.

According to the analysis of my genome, my haplogroup is H4a. Haplogroups describe the mutations on our mitochondrial DNA, passed down through the maternal line, and can theoretically be used to trace a migratory path all the way back to Africa. H4a is a group shared by people in Europe, unsurprisingly, and western Asia. It is, the genome-testing company assures me, the same as Warren Buffets. So what journey did my ancestors take that would result in these mutations and give me typically European features?

I was dumped by helicopter in the wilderness with two other people, a Russian and an indigenous Yukaghir man, with our dogs, our guns, our traps, a little food and a little tea. There we had to survive and get food and furs in the coldest place on Earth where humans live naturally minus 60 degrees.

Eske Willerslev lived for six months as a trapper in Siberia in his 20s. Separately, his identical twin brother Rane did the same. When they were teenagers, their father had regularly left them in Lapland to survive alone in the wilderness for a couple of weeks, fostering a passion for the remote tundra and the people who live there, and they went on increasingly lengthy expeditions. But surviving practically alone was very different. It was a childhood dream, but it was the toughest thing I have ever done, Eske admits.

These experiences affected the twins deeply, and both have been driven towards a deeper understanding of how the challenge of survival has forged us as humans over the past 50,000 years. It led Eske into the science of genetics, and to pioneering the new field of ancient DNA sequencing. Now director of the Centre for GeoGenetics at the Natural History Museum of Denmark, Eske has sequenced the worlds oldest genome (a 700,000-year-old horse) and was the first to sequence the genome of an ancient human, a 4,000-year-old Saqqaq man from Greenland. Since then, he has gone on to sequence yet more ancient humans and, in doing so, has fundamentally changed our understanding of early human migration through Europe and beyond. If anyone can unpick my origins, it is surely Eske.

First, though, I go to meet his twin Rane, who studied humanities, went into cultural anthropology and is now a professor at Aarhus University. Hes not convinced that his brothers genetic approach can reveal all the answers to my questions: There exists an uneasy relationship between biology and culture, he tells me. Natural scientists claim they can reveal what sort of people moved around, and they are not interested in having their models challenged. But this cannot tell you anything about what people thought or what their culture was.

To put this point to Eske, I visit him in his delightful museum office, opposite a petite moated castle and in the grounds of the botanic gardens there could scarcely be a more idyllic place for a scientist to work. Greeting him for the first time, just hours after meeting Rane, is disconcerting. Identical twins are genetically and physically almost exactly the same looking back, many years from now, at DNA left by the brothers, it would be all but impossible to tell them apart or even to realise that there were two of them.

Eske tells me that he is increasingly working with archaeologists to gain additional cultural perspective, but that genetic analysis can answer questions that nothing else can. You find cultural objects in certain places and the fundamental question is: Does that mean people who made it were actually there or that it was traded? And, if you find very similar cultural objects, does that mean there was parallel or convergent cultural evolution in the two places, or does that mean there was contact? he explains.

For example, one theory says the very first people crossing into the Americas were not Native Americans but Europeans crossing the Atlantic, because the stone tools thousands of years ago in America are similar to stone tools in Europe at the same time. Only when we did the genetic testing could we see it was convergent evolution, because the guys carrying and using those tools have nothing to do with Europeans. They were Native Americans. So the genetics, in terms of migrations, is by far the most powerful tool we have available now to determine: was it people moving around or was it culture moving around? And this is really fundamental.

What Eske went on to discover about Native American origins rewrote our understanding completely. It had been thought that they were simply descendants of East Asians who had crossed the Bering Strait. In 2013, however, Eske sequenced the genome of a 24,000-year-old boy discovered in central Siberia, and found a missing link between ancient Europeans and East Asians, the descendants of whom would go on to populate America. Native Americans can thus trace their roots back to Europe as well as East Asia.

And what about my ancestors? I show Eske the H4a haplotype analysed by the sequencing company and tell him it means Im European. He laughs derisively. You could be and you could be from somewhere else, he says. The problem with the gene-sequencing tests is that you cant look at a population and work back to see when mutation arose with much accuracy the error bars are huge and it involves lots of assumptions about mutation rates.

This is why ancient genetics and ancient genomics are so powerful you can look at an individual and say, Now we know we are 5,000 years ago, how did it look? Did they have this gene or not?

The things that we thought we understood about Europeans are coming unstuck as we examine the genes of more ancient people. For example, it was generally accepted that pale skin evolved so we could get more vitamin D after moving north to where there was little sun and people had to cover up against the cold. But it turns out that it was the Yamnaya people from much further south, tall and brown-eyed, who brought pale skins to Europe. Northern Europeans before then were dark-skinned and got plenty of vitamin D from eating fish.

It is the same with lactose tolerance. Around 90 per cent of Europeans have a genetic mutation that allows them to digest milk into adulthood, and scientists had assumed that this gene evolved in farmers in northern Europe, giving them an additional food supply to help survive the long winters. But Eskes research using the genomes of hundreds of Bronze Age people, who lived after the advent of farming, has cast doubt on this theory too: We found that the genetic trait was almost non-existent in the European population. This trait only became abundant in the northern European population within the last 2,000 years, he says.

It turns out that lactose tolerance genes were also introduced by the Yamnaya. They had a slightly higher tolerance to milk than the European farmers and must have introduced it to the European gene pool. Maybe there was a disaster around 2,000 years ago that caused a population bottleneck and allowed the gene to take off. The Viking sagas talk about the sun becoming black a major volcanic eruption that could have caused a massive drop in population size, which could have been where some of that stock takes off with lactose.

While ancient genomics can help satisfy curiosity about our origins, its real value may be in trying to unpick some of the different health risks in different populations. Even when lifestyle and social factors are taken into account, some groups are at significantly higher risk of diseases such as diabetes or HIV, while other groups seem more resistant. Understanding why could help us prevent and treat these diseases more effectively.

It had been thought that resistance to infections like measles, influenza and so on arrived once we changed our culture and started farming, living in close proximity with other people and with animals. Farming started earlier in Europe, which was thought to be why we have disease resistance but Native Americans dont, and also why the genetic risks of diabetes and obesity are higher in native Australian and Chinese people than in Europeans.

We sequenced a hunter-gatherer from Spain, and he showed clear genetic resistance to a number of pathogens that he shouldnt have been exposed to, says Eske. Clearly, Europeans and other groups have a resistance that other groups dont have, but is this really a result of the early agricultural revolution in Europe, or is something else going on?

Eskes analysis of people living 5,000 years ago has also revealed massive epidemics of plague in Europe and Central Asia, 3,000 years earlier than previously thought. Around 10 per cent of all skeletons the team analysed had evidence of plague. Scandinavians and some northern Europeans have higher resistance to HIV than anywhere else in the world, Eske notes. Our theory is that their HIV resistance is partly resistance towards plague.

It could be that the cultural changes we have made, such as farming and herding, have had less influence on our genes than we thought. Perhaps it is simply the randomness of genetic mutation that has instead changed our culture. Theres no doubt that where mutations have occurred and spread through our population, they have influenced the way we look, our health risks and what we can eat. My ancestors clearly didnt stop evolving once theyd left Africa were still evolving now and they have left an intriguing trail in our genes.

At the Gibraltar Museum, a pair of Dutch archaeology artists have created life-size replicas of a Neanderthal woman and her grandson, based on finds from nearby. They are naked but for a woven amulet and decorative feathers in their wild hair. The boy, aged about four, is embracing his grandmother, who stands confidently and at ease, smiling at the viewer. Its an unnerving, extraordinarily powerful connection with someone whose genes I may well share, and I recall Clives words from when I asked him if modern humans had simply replaced Neanderthals because of our superior culture.

That replacement theory is a kind of racism. Its a very colonialist mentality, he said. Youre talking almost as if they were another species.

This articlewas first published by Wellcomeon Mosaic and is republished here under a Creative Commons licence

Professor Eske Willerslev is a research associate at the Wellcome Trust Sanger Institute, which is funded by a core grant from the Wellcome Trust, which publishes Mosaic

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What does it mean to be human? - The Independent

Genetic sequencing offers same-day TB testing – HealthCanal.com (press release) (blog)

Researchers have for the first time shown that standard tuberculosis (TB) diagnostic tests can be replaced by a sub-24 hour genetic test applied to the TB bacteria in a patients sputum.

It currently takes up to two months to obtain the full diagnostic information for a patient with TB, as the bacteria grow very slowly in the laboratory. Scientists have sought for years to bypass this time-consuming step by examining the bacterial DNA directly from a sputum sample. However since most of the cells in sputum are human, it is difficult to spot the signal (TB DNA) within the noise (human and other bacteria) and even harder to find a method that might be affordable and practical across the world.

The new process, led by researchers from the University of Oxford and described in the Journal of Clinical Microbiology, rapidly processes the sputum to preferentially retain TB, using simple and relatively affordable materials, and then sequences and analyses the bacterial DNA. The Oxford team worked with researchers from the University of Nottingham, the Foundation for Medical Research, Mumbai, and Public Health England.

Until recently, DNA sequencing has required heavy machines and a well-equipped laboratory, which has limited its potential applications in the field. In this study, researchers have also shown that by using a new, real-time, handheld sequencing device (Oxford Nanopore MInION) they can achieve identical results, but with a process that might be applied anywhere in the world. In one example they achieved an effective turnaround time of 12.5 hours.

By using DNA sequencing, not only does this method detect drug-resistant TB bugs vital information for the patient but it also enables the tracking the geographical spread of strains, which is hugely valuable to public health workers, and something traditional tests cannot do.

TB is one of the top causes of death by infectious disease in the world, with 10.4 million cases of the disease in 2015, and 1.1 million deaths directly attributable to TB.

Dr Zamin Iqbal from the Wellcome Trust Centre of Human Genetics at Oxford University, who co-led the study, said: One of the great challenges with the management of TB is the need for rapid, comprehensive tests that do not require a hi-tech laboratory. We have shown that it is possible to get all information needed both for clinical management and for tracking disease spread, all within 24 hours of taking the sample from the patient. Further, by achieving this with a handheld device, we open the door to in-field diagnostic tests for TB.

Dr Antonina Votintseva, lead author, said: Although genome sequencing has been used increasingly in research for analysing TB, the limiting factor has continued to be the weeks spent culturing the bacteria in the laboratory. By developing an affordable and simple method for extracting M. tuberculosis DNA direct from sputum, and thereby cutting turnaround time to below 24 hours, we have taken a great step towards comprehensive point-of-care diagnosis.

There is more work to be done of course our goal is to return test results before the patient leaves their clinic, with huge potential for reducing transmission of the disease, and of drug resistance.

Dr Stephen Caddick, Wellcome Trust Director of Innovation, said: It can take many weeks for conventional tests for TB to provide results. Dr Iqbal and his team have made a significant breakthrough by developing a low-cost DNA extraction method which enables TB whole genome sequencing direct from patient samples and provides results in less than a day. The ability to use this technology to identify bacterial strains that may be resistant to antibiotic treatment, particularly in low and middle income countries, could be invaluable in the fight to tackle drug-resistant infections.

The full paper, Same-day diagnostic and surveillance data for tuberculosis via whole genome sequencing of direct respiratory samples, can be read in the Journal of Clinical Microbiology (JCM).

This research was funded by the Wellcome Trust, Royal Society and the NIHR Oxford Biomedical Research Centre.

University of Oxford

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Genetic sequencing offers same-day TB testing - HealthCanal.com (press release) (blog)

Short men are more likely to go BALD claim genetic scientists after exhaustive study – Mirror.co.uk

Keeping a thick head of hair into your twilight years could be more difficult if you're short.

Researchers at the University of Bonn in Germany have linked hair loss in the human genome to height, skin colour and bone density.

We were able to identify 63 alterations in the human genome that increase the risk of premature hair loss," said Dr Stefanie Heilmann-Heimbach, the leader of the study.

"Some of these alterations were also found in connection with other characteristics and illnesses, such as reduced body size."

The data comes from analysing 11,000 men with premature balding and 12,000 that hadn't experienced any hair loss.

The genetic findings also confirm the link between hair loss and an increased risk of prostate cancer.

The link with heart disease is much more complicated. Genes that reduce the risk were found along with genes that increase the risk.

"We have also found links to light skin colour and increased bone density," explains Prof. Markus Nthen, Director of the Institute of Human Genetics at the University of Bonn.

"These could indicate that men with hair loss are better able to use sunlight to synthesise vitamin D. They could also explain why white men in particular lose their hair prematurely."

However, specifically which molecular mechanisms create the link between premature hair loss and other illnesses is only partly understood.

The team says it will be looking into more detail about it in the future. But they did state that losing your hair doesn't mean a fast-track to cancer.

"Men with premature hair loss do not need to be concerned," reassured Prof. Nthen.

"The risks of illness are only increased slightly. It is, however, exciting to see that hair loss is by no means an isolated characteristic, but instead displays various relationships with other characteristics."

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Short men are more likely to go BALD claim genetic scientists after exhaustive study - Mirror.co.uk

This chart is a powerful indictment of our current health-care system – Washington Post

Is the money we're spending on health care keeping us alive?

On a certain level, that's the big test of any health-care systemand the United States isfailing.

According to abovechart, U.S. life expectancy continues to lag far behind other developed countries, despite spending way more on medical treatments aimed at keeping us alive.

The chart, courtesy of Oxford economist Max Roser, plots per-capita health-care spending against life expectancy for the world's wealthiest countries over the past 40-plus years. Each country gets one line, which plots its trajectory on those measures over time.

Looking at the chart, two things become clear: AsRoser notes, the big takeaway is that, in wealthy countries, more spending on health leads to a longerlife expectancy.

But there's a secondary finding: Not all health-care spending is created equal. In the United States, the inflation-adjusted per-capita annual health spending has exploded from1970, when it was less than $500 a year, to 2014, when it was about $9,000 a year.

That's $2,000 more per person per year than the second highest-spending country on the chart, Switzerland. But despite that big spending, growth in American life expectancy has been anemic. Essentially,we spend a lot of money but haven't seen much in the way of life expectancy gains because of it.

The comparison with Japan is instructive. In 1970, average life expectancy in Japan was 72 years, similar to the expectancy of 71 years in the United States. By 2014, U.S. life expectancy crept up by eightyears, to 79. But in Japan, life expectancy grew by a whopping 12 years to 84. And today the United States spends more than twice as much on health care, per capita, than does Japan.

There are a lot of factors influencing these numbers, particularly on the longevity side of the equation: differences in lifestyle and eating habits, exercise, culture, etc. But on the spending side there's an elephant in the room: According to the Organization for Economic Cooperation and Development, the United States is the only country on the chart that doesn't have universal health coverage.

Life expectancy isa great shorthand for overall health and well-being. After all, as economists David Cutler, Angus Deaton and Adriana Lleras-Muney wrote in 2006, The pleasures of life are worth nothing if one is not alive to experience them.

But the importance of life expectancy, and thecountry'sdismal standing in it, suggests the United Statesshould be more than a little skeptical when any politician as they so often do proclaims that any policy changes threaten to changethe greatest health care system in world history.

After all, if our health care is so great, why are we paying more and dying sooner?

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This chart is a powerful indictment of our current health-care system - Washington Post

A state single-payer healthcare system? Nice idea, but it’s just California dreaming – Los Angeles Times

Voters want politicians to be bold. They disrespect timidity. And trying to push every Californian into a government-run healthcare system is certifiably bold.

The voters desire for boldness has a caveat, of course: Theyve got to like what the politician is being bold about.

We really dont know how Californians feel about government-run universal healthcare. People havent been asked for a while.

The Public Policy Institute of California surveyed voters in January, however, and found that 54% opposed congressional repeal of the Affordable Care Act, or Obamacare.

But for generations, it has been the dream of many mostly Democrats to enact whatever you want to call it: single-payer, Medicare-for-all or socialized medicine.

Now, with congressional Republicans and President Trump trying to repeal and replace Obamacare, some Sacramento Democrats think they see an opening to finally adopt a California version of single-payer.

Under single-payer, healthcare costs are paid for by the government, rather than by private insurance. The healthcare itself is still delivered by private physicians.

Some version that would allow people to buy supplemental private insurance call it Medicare-for-all presumably could fit into the system these Democrats envision.

We really dont know because they havent actually proposed anything. Theyre promising details in two weeks. So far, theyve just tucked the concept of single-payer into an essentially hollow bill, SB 562, by Sens. Ricardo Lara (D-Bell Gardens) and Toni Atkins (D-San Diego).

The bill merely declares: It is the intent of the Legislature to enact legislation that would establish a comprehensive universal single-payer healthcare coverage program and a healthcare cost control system for the benefit of all residents of the state.

Yes, that means all whether theyre in the country legally or not.

Medi-Cal, the states enhanced version of federal Medicaid for poor people, already covers children here illegally. But not their parents.

Lara told me that he mentioned to one kid that the Legislature had extended Medi-Cal to undocumented children.

He said, Thank you senator, but what about my mom? Lara recalled. What about my dad? How do we get to healthcare for everyone?

With great difficulty, Id say. And the same for enacting any single-payer system.

Dreams can be good. But this dream especially with Trump and conservative Republicans controlling the national agenda seems like wishful fantasy, even in deep blue California.

The envisioned policy long has made sense. Cut out the insurance industry profiteering and reduce healthcare costs. Perhaps eliminate co-pays and deductibles, as Lara wants to do.

Even Medicare-for-all would be better than what most people have today. Ever hear a senior seriously complain about Medicare? I havent.

Most industrialized nations have some sort of government-run healthcare coverage either single-payer or a hybrid public-private system.

But good policy aside, there are two huge obstacles to a state going solo: financing and politics.

In California, it would cost the state tens of billions of dollars. Whod pay for that? Business, which presumably would no longer need to provide employees with health insurance? Wage earners through payroll withholding? Medical providers? How much would the federal government kick in? Anything?

That presumably will be in the bills details. Good luck.

And how would this legislation ever get passed? The politics are daunting. The insurance industry would fight with all it has meaning campaign money. So would many healthcare providers that historically have feared socialized medicine.

On the other side, the California Nurses Assn. is the bills chief sponsor. And that labor union has influence among liberals.

But nothing of this magnitude and controversy can pass the Legislature without a committed governor pushing strongly. And Gov. Jerry Brown hasnt said a peep about single-payer healthcare since he was elected in 2010. Moreover, the normally cautious skinflint is not likely to commit the state to such a financial gamble.

No other state has a single-payer plan. Vermont did briefly, but scrubbed it in 2014 because of high costs and unpopular taxes.

The California Legislature passed a single-payer bill sort of when Arnold Schwarzenegger was governor, but he vetoed it.

Actually, it wasnt a real single-payer plan anyway. It didnt include any financing. That was to be passed later and required a two-thirds supermajority vote. No way.

Updates from Sacramento

Democrats currently hold a supermajority in each house. But you can bet not all are inclined to vote for a tax increase. Possibly for highway repairs, but not for an untested, radical change in healthcare coverage.

The time is right, the time is now, insists Lara, whos thinking about running for state insurance commissioner next year. California can be the national laboratory for our country.

What everyone agrees on, he adds, is we need to have an alternative to threatened Obamacare.

But many Democrats believe their best hope is congressional gridlock and the blockage of repeal.

Perhaps Im like Alice in Wonderland, but I really am hopeful, says state Sen. Holly Mitchell (D-Los Angeles), the Budget Committee chairwoman. Theres an amazing groundswell of people showing up all over the country fighting to retain the Affordable Care Act.

What about single-payer? I honestly dont know.

Not a lot of enthusiasm there.

She sounds like other Democrats who privately believe the focus should be on preserving what they can of Obamacare, which has pumped nearly $24 billion annually into California healthcare and halved the number of uninsured.

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A state single-payer healthcare system? Nice idea, but it's just California dreaming - Los Angeles Times

Pence headed to Louisville to promote health care bill – USA TODAY

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Vice President Pence delivers remarks on the American Health Care Act to the news media after attending the Senate Republican policy luncheon on March 7, 2017.(Photo: Shawn Thew, European Pressphoto Agency)

WASHINGTON Vice President Pence will travel to the Louisville area Saturday to talk about health care and the economy with Kentucky Gov. Matt Bevin, according to the vice presidents office.

Details are expected to be released later Thursday.

Louisville airport officials had been told President Trump was coming, the Courier-Journal reported Wednesday.

Kentucky Sen. Rand Paul is among the conservative lawmakers who have criticized the House GOP bill to overhaulthe Affordable Care Act, saying it doesnt do enough to dismantle the law.

Trump tweeted Wednesday: I feel sure that my friend @RandPaul will come along with the new and great health care program because he knows Obamacare is a disaster!

Republicans have a slim margin in the Senate and will have a difficult time crafting health care legislation that can satisfy both conservatives and moderates. If three Republican senators oppose the bill, united Democratic opposition can stop it.

Pence has been making multiple media appearances and meeting with lawmakers to shore up support for the legislation, which is opposed by major health care groups such as the American Medical Association and the American Hospital Association.

Pence tweeted out his support Thursday morning for the House Ways and Means Committee, which worked through the night to markup its portion of the legislation

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Q&A: The facts on the Republican health care bill

4 key ways the House Republicans' health care bill changes Obamacare

House panel OKs health bill, industry groups say no

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Precision Medicine Project Mulls How to Return Genetic Test Results to 1 Million Participants – GenomeWeb

NEW YORK (GenomeWeb) Before the National Institutes of Health can begin to genetically test participants within its precision medicine initiative, it will have to figure out what results to return, how to minimize reporting false positives, and how to provide counseling to help them navigate the often uncertain and evolving evidence on genetic information.

And the project will have to figure out how to do all this on an unprecedented scale, for a million participants that the All of Us Research Program hopes to enroll over the next four years.

A trial upgrade to GenomeWeb Premium gives you full site access, interest-based email alerts, access to archives, and more. Never miss another important industry story.

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Precision Medicine Project Mulls How to Return Genetic Test Results to 1 Million Participants - GenomeWeb

Liberals defy PM, approve genetic testing bill he calls unconstitutional – Medicine Hat News

By Kristy Kirkup, The Canadian Press on March 8, 2017.

OTTAWA Liberal backbenchers have defied Prime Minister Justin Trudeau, voting in favour of a bill that would bar health and life insurance companies from forcing clients to disclose the results of genetic testing.

Just hours before the vote late Wednesday in the House of Commons, Trudeau said the proposed law is unconstitutional because it intrudes on provincial jurisdiction. He recommended that MPs vote against it.

But most Liberal backbenchers, along with Conservative and New Democrat MPs, ignored Trudeaus warning. The bill passed by a vote of 222-60.

It was a free vote, meaning Liberal backbenchers were not required to toe the party line. They did, however, come under pressure from the government, including Trudeau.

Earlier in the day, Trudeau told a news conference that the federal government has to consider multiple factors when making decisions on legislation, including defending the rights of Canadians and upholding their freedom from discrimination.

He added that it also has to defend the Constitution and the balance of power between federal and provincial jurisdictions, he added.

The government has taken a position that one of the elements in the proposed bill is unconstitutional, Trudeau said. That is the recommendation we had and the government position is to vote against that particular element in the bill.

Justice Minister Jody Wilson-Raybould had gone to some lengths to rally opposition to the bill. Last week, she sent a letter to the head of the Council of the Federation, which comprises the countrys premiers, which appeared designed to solicit provincial and territorial support for the federal governments position.

Given the important constitutional issues in play, we call on the Council of the Federation to communicate its views on the constitutionality of Bill S-201s proposal to regulate all contracts, agreements, and goods and services to prohibit genetic discrimination, Wilson-Raybould wrote.

The insurance industry has fiercely opposed an aspect of the legislation that would make it illegal for anyone to require a person to undergo genetic testing, or disclose the results of previous tests, as a condition of signing or continuing an insurance policy or any other good, service, contract or agreement.

If passed, it would also prohibit anyone from sharing genetic testing results without written consent, although there are exceptions for physicians and researchers.

A breach of the proposed law would result in a fine of up to $1 million, or five years behind bars.

The government had proposed an amendment that would have stripped the bill of everything except the power to make genetic characteristics a prohibited ground of discrimination under the Canadian Human Rights Act. It was defeated by a vote of 218-59.

The amendment would have gutted the legislation, said Rob Oliphant the Liberal MP who shepherded the bill, originally proposed by now-retired Sen. James Cowan, through the Commons.

It would have meant the bill would apply only to federally regulated employees, who account for just five to seven per cent of the population.

Oliphant argued that the bill is an appropriate federal response in an area where provinces and territories have failed to act for a dozen years. And he noted that three legal experts testified before the Commons justice committee about its constitutionality.

with files from Joanna Smith

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Liberals defy PM, approve genetic testing bill he calls unconstitutional - Medicine Hat News

Proposal Urges Stronger Focus on Social and Environmental Factors in Precision Medicine – Newswise (press release)

Newswise When it comes to having good health or getting sick, a persons genetic code is important. But so is a persons zip code. These strong influences are all part of precision medicine, which includes analysis of an individuals genes, environment and lifestyle to inform disease prevention and treatment.

Yet genes tend to be the main focus in research and practice, often leaving out the social and environmental parts of the story. Researchers at Ann & Robert H. Lurie Childrens Hospital of Chicago propose new terminology for social and environmental influences on health, in efforts to balance the predominant emphasis on genes in precision medicine. Their proposal, entitled The Missing Omes: Proposing Social and Environmental Nomenclature in Precision Medicine, was published in Clinical and Translational Science.

Although where a child lives and goes to school often has more bearing on his or her health than the genetic code, social and environmental factors get far less attention than the genetic influences in precision medicine research, says lead author Matthew Davis, MD, MAPP, Division Head of Academic General Pediatrics and Primary Care at Lurie Childrens, and Professor of Pediatrics and Medical Social Sciences at Northwestern University Feinberg School of Medicine. We hope that the broader and more consistent terminology we propose will facilitate more collaboration across scientific disciplines. Whenever we open new lines of communication between fields that rarely talk with one another, the possibility of advancing understanding and improving health grows exponentially.

The authors suggest a naming system that expands the -omes discussed in precision medicine, such as the genome or proteome, which describe the factors within an individuals body that impact disease or wellness. They call these internal domains the endome. Similarly, they refer to the many influences on health that come from outside the individual as the ectome. For example, health-related aspects of a persons social support network are called the philome and diet-related factors fall into the nutriome, while health-affecting components of water sources belong in the hydrome.

By adding the social and environmental -omes we hope to expand the precision medicine paradigm and encourage more comprehensive data collection in efforts to understand and prevent disease, says co-author Thomas Shanley, MD, Chair of the Department of Pediatrics at Lurie Childrens and Northwestern University Feinberg School of Medicine, Chief Research Officer at the Stanley Manne Childrens Research Institute, and the Founders Board Centennial Professor. We need a common language and inclusion of all the known determinants of human health to push the field of precision medicine forward.

To advance these concepts and develop a repository of rigorous measures for the different -omes, the authors have launched a website http://www.omecentral.org. We hope that OmeCentral.org will serve as an online forum for scientists, spurring conversation and innovative ideas, says Davis, who is the A Todd Davis, MD, Professor and Director of the Mary Ann & J. Milburn Smith Child Health Research Program. He also serves as Associate Chief Research Officer for Health Services and Policy Research at the Stanley Manne Childrens Research Institute at Lurie Childrens. We welcome experts in different fields to suggest the most appropriate objective measures for the various social and environmental impacts on health.

Research at Ann & Robert H. Lurie Childrens Hospital of Chicago is conducted through the Stanley Manne Childrens Research Institute. The Manne Research Institute is focused on improving child health, transforming pediatric medicine and ensuring healthier futures through the relentless pursuit of knowledge.

Lurie Childrens is ranked as one of the nations top childrens hospitals in the U.S.News & World Report. It is the pediatric training ground for Northwestern University Feinberg School of Medicine. Last year, the hospital served more than 198,000 children from 50 states and 51 countries.

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Proposal Urges Stronger Focus on Social and Environmental Factors in Precision Medicine - Newswise (press release)

Structured assessment and followup for patients with hereditary kidney tumour syndromes. – UroToday

Optimal clinical assessment and subsequent followup of patients with or suspected of having a hereditary renal cell carcinoma syndrome (hRCC) is not standardized and practice varies widely. We propose protocols to optimize these processes in patients with hRCC to encourage a more uniform approach to management that can then be evaluated.

A review of the literature, including existing guidelines, was carried out for the years 1985-2015. Expert consensus was used to define recommendations for initial assessment and followup.

Recommendations for newly diagnosed patients' assessment and optimal ages to initiate followup protocols for von Hippel Lindau disease (VHL), hereditary papillary renal cancer (HPRC), hereditary leiomyomatosis with renal cell carcinoma (HLRCC), Birt-Hogg-Dub syndrome (BHD), familial paraganglioma-pheochromocytoma syndromes (PGL-PCC), and tuberous sclerosis (TSC) are proposed.

Our proposed consensus for structured assessment and followup is intended as a roadmap for the care of patients with hRCC to guide healthcare providers. Although the list of syndromes included is not exhaustive, the document serves as a starting point for future updates.

Canadian Urological Association journal = Journal de l'Association des urologues du Canada. 2016 Jul 12 [Epub]

Jean-Baptiste Lattouf, Stephen E Pautler, M Neil Reaume, Raymond H Kim, Melanie Care, Jane Green, Alan So, Philippe D Violette, Issam Saliba, Philippe Major, Shane Silver, Richard Leicht, Joan Basiuk, Simon Tanguay, Michael A S Jewett, Darrel Drachenberg, Kidney Cancer Research Network of Canada

Division of Urology, Department of Surgery, University of Montreal Hospital Centre, Montreal, QC, Canada., Divisions of Urology and Surgical Oncology, Departments of Surgery and Oncology, Western University, London, ON, Canada., Division of Medical Oncology, The Ottawa Hospital Cancer Centre, University of Ottawa, Ottawa, ON, Canada., Division of Medical Oncology, Department of Medicine, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON, Canada., Fred A. Litwin Family Centre in Genetic Medicine, University Health Network & Mount Sinai Hospital, Toronto, ON, Canada., Disciplines of Genetics and Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada., Department of Urologic Sciences, Faculty of Medicine, Vancouver General Hospital and University of British Columbia, Vancouver, BC, Canada., Division of Urology, Department of Surgery, Woodstock General Hospital, Woodstock, ON, Canada., Division of ENT, Department of Surgery, University of Montreal Hospital Centre, Montreal, QC, Canada., CHU Sainte-Justine, Department of Neurosciences, University of Montreal, Montreal, QC, Canada., Faculty of Medicine and the Division of Dermatology, University of Manitoba, Winnipeg, MB, Canada., Department of Ophthalmology, Faculty of Medicine, University of Manitoba, Winnipeg, MB, Canada., Kidney Cancer Research Network of Canada, Toronto, ON, Canada., Division of Urology, McGill University, Montreal, QC, Canada., Division of Urology, Departments of Surgical Oncology and Surgery, Princess Margaret Cancer Centre and the University Health Network, University of Toronto, Toronto, ON, Canada., Section of Urology, Department of Surgery, University of Manitoba, Winnipeg, MB, Canada.

PubMed http://www.ncbi.nlm.nih.gov/pubmed/28255411

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Structured assessment and followup for patients with hereditary kidney tumour syndromes. - UroToday

The world is running out of water. But genetic engineering can help – CityMetric

In the village of Kafr on the western edge of Greater Cairo you can see this almost color-coded conflict.

Its not a village in the traditional sense though. Brick high-rises stretch ten or 12 stories into the air between fields of alfalfa and leeks.

This is the most ubiquitous architecture of Egypts capital: unpainted red brick buildings that, when combined with their concrete beams and columns, look like Brutalist takes on plaid. Until the 1970s most bricks came from nearby, made from Nile silt, which also provided the rich topsoil that provided the foundation for agriculture in Egypt.

These brick buildings and farmland are now in direct competition with each other for space.

Most new construction in Egypt is on that agricultural land, despite a complete ban on the practice. Each year, 16,000 acres of agricultural land are built on, according to 10 Tooba, an independent urbanism organization.

The fertile Nile Delta, at the base of which Cairo sits, seen from space. Image: NASA

With only 2.75 per cent percent of Egypts land suitable for farming, and decreasing on a per capita basis, the land becomes more precious each day.

Kamel Sayyed moved to Kafr six years ago from another nearby village to take advantage of the cheaper rents. He rented an apartment then for 300 Egyptian pounds (EGP) a month, or 45 at the time.

Soon though, growth exploded. Building was long illegal and enforcement piecemeal, but when Hosni Mubarak was overthrown in 2011, a security vacuum started a blitz on illegal building.

Sayyed says that almost immediately after Mubarak was forced from office, heavy machinery started digging foundations. Steel, concrete, and brick prices increased overnight. Egypts Informal Settlements Development Fund, a government organization, said there was a 10 to 20 per cent increase in three years.

South of Cairo, hundreds of smoke stacks extend to the horizon for as far as the eye can see. Each of these furnaces can churn out 250,000 red bricks everyday, feeding the citys appetite for housing and development. This summer, only two or three were operating, as fuel prices were outpacing how much the factoriescould sell.

Development in Cairo has become sprawling and indiscriminate. Image: Allan Doyle

The government has encouraged development on desert land, in new satellite cities, and suburban-gated communities. One former Egyptian prime minister even referred to the escape from the Nile Valley as a matter of life and death.

These new cities, as they are known in Egypt, get 29.8 billion EGP in investment, while existing cities got 28.4 billion. New cities only host about two per cent of Egypts population, though.

For the 16,000 acres of rural land thats built on each year, Shawkat says that only 4,000 acres of desert land are developed. Rural growth rates are doing something in Egypt that doesnt happen in most of the Global South outpacing urban growth. Still, Cairo is listed as the fastest growing city worldwide in terms of population.

Part of building on agricultural land is because there is need, says Yahia Shawkat of 10 Tooba. There is a human, other part, which is speculation: land prices or property prices are really the only thing sort of rising in terms of value in Egypt.

Urbanizing agricultural land is much, much more profitable than tilling it.

With 52 per cent of farmers in the country being small farmers, the difference in profit presents a straightforward economic choice for many, for the time being.

Building on agricultural land in Kafr has become an industry. Sitting in his office in Kafr, Hany Mahmouf Hafez, who works in construction, says that a single apartment can fetch at least 6,950, while a floor can cost between 900 and 1,400 to build. By comparison, an acre of land can bring in 90 or 140 a year. A woman picking out paint interrupted to say that its the best way to make money in the town.

Whether agricultural land will remain less profitable is up for debate.

Since Egypt floated its currency, agriculture seems more profitable, with food exports rising and imports declining.

For many, real estate was seen as a hedge against a declining currency. With the floatation, real estate might not be as good an investment in the short or medium term.

The Nile runs through Cairo's heart.Image: Blueshade

The proposed legislation is an outright ban on building on agricultural land, but that is far from the reality. The idea is to freeze the encroachment of cities into farmland and push it out into the desert, hence the massive investment into new cities.

But informal settlements that encroached onto farmland had what the new communities didnt. They were near existing networks of water, sewage, and electricit, and even though they couldnt be connected legally, a contractor could pay a bribe.

Contractors can pay 230 for an apartment to get power, or 900 for a full building to be connected to the grid. In order to prevent the huge drains on the power grid, the Egyptian government has put these informal settlements in a legal grey area by a partial legalization of unofficial power meters.

Its a tricky problem. The outright ban isnt working due to a lack of so-called soft infrastructure. The government has built roads, pipes, and power lines, but hasnt provided enough schools, hospitals, and cultural activities to make living there make sense.

Its difficult to think about how to allow rural growth, when ideally it would be minimized. Shawkat says there are ways to build in growth in a way that is sustainable.

Ill do it in a certain density and a certain way that would actually I would lose maybe ten acres, but Im going to save 50.

Whether the government plans to do that isnt clear, and the long-term plan for food security is similarly hazy.

In the longer term, Egypt may need to learn to break with thousands of years of tradition, and start growing horizontally east to west, rather than north to south along the Nile.

If it cant, Egypts burgeoning cities will choke the fertile farmland of the Nile on which its heritage was built.

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The world is running out of water. But genetic engineering can help - CityMetric

Angiogenic Gene Therapy for the Heart: Overcoming the Roadblocks – Drug Discovery & Development

The human heart has an innate capacity to remodel in response to advancing coronary artery disease. As plaque builds up in the hearts three major arteries, some genetically privileged patients begin to grow small collateral blood vessels to overcome restricted blood flow and improve cardiac perfusion. This process is known as cardiac angiogenesis. With the passage of time, this response is overrun by disease progression.

Researchers have long wondered if this primal angiogenic healing response could be amplified and regulated through the design and development of angiogenic therapeutics. In recent years, monoclonal antibody therapies have proven effective at harnessing the human bodys natural biological mechanisms to treat cancer. Similarly, within cardiac care, angiogenic gene therapy has shown great promise.

In the U.S., more than one million patients with advanced coronary artery disease suffer from recurrent and severe chest pain, which profoundly limits their physical activity and quality of life. These refractory angina patients are no longer responsive to anti-anginal medications and are either not candidates for stent implantation or bypass surgery, or continue to suffer from angina even after these mechanical revascularization procedures. While drug and proteins appear unsuitable, new research and clinical studies focused on angiogenic gene therapy are now showing great promise as a one-time treatment for more than one million patients in the U.S. with advanced coronary artery disease and refractory angina.

The successful commercialization of an angiogenic gene therapy will require (1) an angiogenic growth factor that regulates the multiple proteins required to orchestrate micro-vessel growth and enlargement; (2) a simple percutaneous catheter-based delivery system to deliver the angiogenic gene therapy into heart cells; and (3) a deep understanding and characterization of patients who are most likely to benefit from angiogenic gene therapy, enabling design of a clinical study properly powered to detect treatment effects and assess potential risk-benefit.

Choice of Angiogenic Growth Factor

One key element of successful gene therapy is gene expression in the targeted cells, at a functional level. For angiogenic gene therapy, a central challenge has been identifying the growth factors that can stimulate the complex angiogenic biological process. It has been debated and widely studied whether the delivery of vascular endothelial growth factor (VEGF) or other growth factors, alone or in combination, is ideal for collateral vessel development. Recent research suggests a more fruitful approach may be the use of a specific regulatory gene, FGF-4, that is now known to activate VEGFs and the cascade of events required to stimulate cardiac angiogenesis. Using a regulatory gene is likely more practical than trying to determine which individual growth factor or growth factor combination is best suited for the job.

Simplified Catheter-Based Delivery Options

Even with firm understanding of the merits of individual angiogenic growth factors, a separate question remains: Which DNA delivery system is best suited for cardiovascular angiogenic gene therapy?

Advances have come with a key realization: the facilitation of coronary collateral formation requires a relatively short duration of gene expressiononly a few weeks. Vector systems that meet this requirement include plasmid constructs and adenovirus. So here was the next challenge: determining which of these two approaches was optimal. Plasmids are easy to manufacture and safe but have very low level and short duration of muscle transduction and could be delivered to the heart mainly through direct intramuscular injections. Adenoviral vectors, on the other hand, can be administered via the intravascular route and have been shown to achieve high transfection efficiency in heart muscle cells with transgene expression lasting for two to six weeks. The relatively short duration of growth factor gene expression by the adenovirus serotype 5 (Ad5) vector has proved sufficient for the building of new functional biological structures such as coronary collateral vessels.

Studies have demonstrated that fibroblast growth factor-4 (FGF-4) can promote the growth of existing or new collateral vessels in the heart, when delivered as a gene within an Ad5 vector. The resulting molecular packagenamed Ad5FGF-4is delivered into the heart as a one-time treatment during a standard angiogram-like procedure. The biologic is delivered in front of a balloon that briefly blocks blood flow, allowing the treatment to more easily leave the blood vessel and enter the cardiac muscle. FGF-4 gene expression promotes the development of new collateral vessels and the enlargement of existing collateral vessels in ischemic areas of the heart, to increase blood flow to these oxygen-starved regions.

Effective Clinical Study Design

An additional hindrance to historical progress in cardiovascular gene therapy may have involved study design. The standard endpoint used in most cardiovascular therapeutic angiogenesis studiese.g., exercise tolerance testing (ETT)is based on decades of experience with clinical development of small molecule anti-anginal drugs, and is still considered by regulatory authorities to be a relevant indicator of clinical effectiveness. In general, clinically significant improvements in ETT time resulting from mechanical revascularization (bypass surgery and stents), pharmacologic interventions or gene therapy, represent improved functional capacity for treated patients. ETT is known to be subject to placebo effect, and therefore careful study design, including well-defined patient inclusion criteria (e.g. limited baseline ETT capacity) and controlled testing conditions and criteria are essential for meaningful outcomes.

An attempt to fuse the insights and overcome the roadblocks summarized above are fueling ongoing efforts to improve and advance angiogenic gene therapy. Future studies are likely to elucidate the most promising therapies for cardiovascular angiogenic gene therapy and offer hope to the many patients for whom angina is currently a source of deep concern causing significant negative impact on quality of life.

Christopher J. Reinhard is Chief Executive Officer of Angionetics Inc., a company focused on the late-stage clinical development and commercialization of Generx, an angiogenic gene therapy product candidate designed for medical revascularization for the potential treatment of patients with myocardial ischemia and refractory angina due to advanced coronary artery disease.

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Angiogenic Gene Therapy for the Heart: Overcoming the Roadblocks - Drug Discovery & Development

Pfizer looks at building major gene therapy manufacturing facility in … – FiercePharma

Pfizer, which scooped up Bamboo Therapeutics last year in its aim to be a major player in gene therapies, is now looking at building a gene therapy production facility in North Carolina where the biotech is based.

Pfizer spokeswoman Kimberly Becker confirmed a report by the Triangle Business Journal that the company has been exploring the area. The newspaper was told by sources that Pfizer has talked to state and local officials about a potential $100 million expansion project. Bamboo is based inChapel Hill.

We recently announced that were moving forward with scoping potential sites in Sanford for our new gene therapy site. This work is still in the preliminary stages and we arent able to share additional detail at this time, Becker said in an email.

The sources told the newspaper thatPfizer also is considering putting it in Massachusetts. The drugmakercurrently is erecting a $200 million biologics and vaccines production facility at its campus in Andover.

But Bamboo already has an 11,000-square foot, fully staffed and operational manufacturing facility in Sanford it acquired last year from the University of North Carolina about the time that Pfizer made an initial investment in the company. Bamboo has produced phase I and II materials using a in the facility using what Pfizer said was superior suspension, cell-based production platform that increases scalability, efficiency and purity.

Pfizer last year bought Bamboo in two-step deal, laying out $193 million to acquire its stock, with a pledge of up to $495 million more in milestones. With gene therapies, genetic material is introduced into a patients body to replace gene mutations that cause disease.

The biotech is working on recombinant adeno-associated virus (rAAV)-based gene therapies for rare diseases. It has a pre-clinical asset for Duchenne Muscular Dystrophy (DMD); and three targeted at the central nervous system, with pre-clinical assets for Friedreichs Ataxia and Canavan disease, and a Phase I asset for Giant Axonal Neuropathy, Pfizer said.

Pfizer first entered the emerging field in 2014 with a deal with Spark Therapeutics in hemophilia. At that time, the company also established a dedicated gene therapy research center in London known as the Genetic Medicines Institute which falls under its Rare Disease Research Unit.

While the field offers the hope of one-time cures by dealing with the genetic root cause of a disease, it offers challenges for insurance coverage and payments. There have been no gene therapies approved yet in the U.S., but Dutch company uniQure developed the firstgene therapy approved in Europe, a treatment thathas been termed the worlds most expensive drug.

Approved in 2012, Glybera is priced at more than $1.2 million. Only one German doctor has been able to win insurance approval, despite the fact the treatment can cure the ultra-rare disease called lipoprotein lipase deficiency. uniQure is now focused on a hemophilia B program, competing with the gene therapy being developed by Spark Therapeutics with Pfizer.uniQure, which has had to eliminatejobs to cut costs, has a $25 million, 55,000-square-foot gene therapy manufacturing facility in Lexington, Massachusetts.

GlaxoSmithKline has also won approval in Europe for Strimvelis, its gene therapy for bubble boy disease. It is offering the one-time treatment at about $665,000, with a money-back guarantee.

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Pfizer looks at building major gene therapy manufacturing facility in ... - FiercePharma

An AI Completed 360000 Hours of Finance Work in Just Seconds – Futurism

A New COIN

JP Morgan Chase & Co. is the biggest bank in the United States. It is one of the largest employers in the American banking sector, with more than 240,000 employeesserving millions of customers. Some of those employees are lawyers and loan officers who spend a total of 360,000 hours each year tackling a slew of rather mundane tasks, such as interpreting commercial-loan agreements. Now, the company has managed to cut the time spent on this work down to a matter ofsecondsusing machine learning.

In June, JP Morgan started implementing a program called COIN, which is short for Contract Intelligence. COIN runs on a machine learning system thats powered by a new private cloud network that the bank uses. Apart from shortening the time it takes to review documents, COIN has also managed to help JP Morgan decrease its number of loan-servicing mistakes. According to the programs designers, these mistakes stemmed from human error in interpreting 12,000 new wholesale contracts every year.

COIN is part of the banks push to automate filing tasks and create new tools for both its bankers and clients. Automation is now a growing part of JP Morgans $9.6 billion technology budget. In fact, over the past two years, technology spending in JP Morgans consumer banking sector has totaled about $1 billion. We have invested heavily in technology and marketing and we are seeing strong returns, the bank said in a presentation prior to its annual investor day.

Over the coming years and decades, artificial intelligence (AI) is expected to usher in a new era of automation. Accordingly, the increase in automated systems will bring with it job displacement in a number of industries, including finance, transportation, manufacturing, information technology, and even law. In total,one study projected that 57 percent of the worlds jobs are at risk of being replaced by automated systems.

This is due, in part, to growing access to technology and cheaper computing systems. Automation can increaseefficiency and limit or altogether eliminate human error, as JP Morgans COIN program has demonstrated. Were starting to see the real fruits of our labor, said Matt Zames, the banks CTO. This is not pie-in-the-sky stuff.

The bank, however, doesnt see their move toward better automated systems as a cause of unemployment. People always talk about this stuff as displacement. I talk about it as freeing people to work on higher-value things, which is why its such a terrific opportunity for the firm, said Dana Deasy, Chief Information Officer at JP Morgan.

Whatever the case may be, automation will cause a job disruption in the years to come. In some places, like JP Morgan, its already begun. Institutions, both private and public, have to be ready to adjust to the economic future automation will bring with it.

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An AI Completed 360000 Hours of Finance Work in Just Seconds - Futurism

Scientists Have Found a Way to Reverse the Signs of Aging – Futurism

Why We Age

In the absence of an actual fountain of youth, people have turned to drugs, creams, and even blood to prevent aging. But it turns out one of the best ways to combat the inevitable was right under our noses all alongexercise.

As we get older our cells lose their ability to generate energy effectively, which leads to the physical changeswe associate with aging.Researchled by Sreekumaran Nair at the Mayo Clinic reveals that high intensity interval training (HIIT) can help reverse those effects.

The study includedvolunteers from two age groups, one between 18 and 30, and the otherbetween 65 to 80. These groups were then divided into three: one received HIIT, another received weight training, and the third group was given a combination of both. All volunteers had to engage in the regimen for three months, and muscle biopsies were taken before and after for comparison.

Aging actually happens at a cellular level. As the mitochondria (the powerhouse of the cell) declines with age, it leads to many age-related conditions everything from worsening eyesight to cancer. HIIT training which involves short bursts of intense physical activity, mixed with periods of lower-intensity exercise can apparently boost the mitochondrias ability to generate energy by 69 percent among older subjects, and 49 percent in a younger group.

Perhaps the most telling sign of cellular aging is when the body begins to have difficultywith specific functions, such as the muscles ability to burn excess blood sugar which could lead to diabetes. HIIT training lead to not just a halt in thedecline, but evenreversed it. After three months of interval training, everything converged towards what we saw in young people, says Nair.

In addition to positive impacton a cellular level, the training also provideda major improvement in lung, heart, and circulation health. The amount of oxygen the younger groupcould inhale rose by 28 percent, androse by 17 percent among the older volunteers.

Among the group that was given weight training instead of HIIT, no mitochondrial or respiratory improvements were observed. Under this exercise regimen, the best benefit received was gaining muscle mass. In the group that received a combination of both, oxygen consumption rose by 21 percent among older volunteers, and showed intermediate results.In a statement announcing their research, Dr. Nair said:

Other research centered around anti-aging efforts are also making significant strides: a drug called metformin, which has long been used to treat diabetes, has just been approved for clinical trials involving its potentialage-related applications. A separate study claims to have formulated a drug that can help slow down the aging process. Having a deeper understanding of genetics has also helped scientists gainnew insights into how we can effectively slow physical aging and the onset of age-related diseases.

Given these findings, combined with numerous breakthroughs in the field, we may be closer to the fountain of youth than we think.

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Scientists Have Found a Way to Reverse the Signs of Aging - Futurism