Four Snacks in Search of an Airline at the World Travel Catering and Onboard Services Expo – APEX Media

Exhibitors at World Travel Catering and Onboard Services Expo in Hamburg. Image: Maxim Sergienko.

For many new snack vendors, landing a deal with an airline would be a dream come true, but its no easy feat. For independent companies, the airline tender process can be too resource-intensive, competitive or just downright intimidating. Youve got to have elephant-thick skin in this business, said Emirates alum and current head of Dnatas catering division, Robin Padgett, at this years World Travel Catering and Onboard Services Expo (WTCE). But if youve got the right product, branding strategy and youre confident in it, dont stop. Keep pushing.

Here are four snacks in search of their first airline customer at WTCE.

Chikas Gluten Free, Vegan West African Snacks

Chika Russell, founder and mogul behind Chikas Snacks, may be familiar to viewers of Dragons Den UK, where she received offers from all of the dragons, eventually accepting one, but later walking away from the agreement to go at it alone. After achieving success in online and retail markets, shes now hoping to bring her Nigerian-inspired snacks on board. Entering the airline space is just an evolution of where our business needs to be as a global player, she says. In her view, landing a deal with an airline likely wont be a huge revenue generating opportunity, but the ability for marketing your brand in airlines, and getting more people seeing drives more brand awareness, makes the airline market an attractive industry. Her snack line ranges from hand-cooked plantain to chickpea crisps and varieties of nuts all infused with a bold kick of flavor.

Biscotteria Bettinas Confezioni Salati

Sourced by trolley innovators and food suppliers Italcarrelli, Biscotteria Bettinas new line of biscuits offers a savory twist: Theyre salty cookies. For salty snacks, were used to seeing chips, but not biscuits, says Sandra Capuzzo, international business relations advisor for Italcarreilli. Perfect as an antipasti or an aperitivo, the biscuits blend traditional Italian ingredients into original combinations like cantucci with peanuts and parmesan, or curry and poppy seed. Those not sure if they should pair their biscuit with an Aperol Spritz or Prosecco can consult the pairings list prepared by Italian sommelier Wladimiro Gobbo. Its something really new for the market, and airlines always want some innovation, something new to offer their customers, says Capuzzo. For those with a sweet tooth, Biscotteria Bettina also offers a line of sweet biscuits.

Bars Chocolate Mallow Hippos

Airlines looking for a hippo in a haystack snack with the potential to surprise and delight passengers may be in luck with Bars Chocolate Mallow Hippos. Available in bars or bite-size servings, the handcrafted marshmallow treats are colorful and come in fun fruity flavors or rich chocolate tastes. Bar has grown its retail footprint, which now spans the globe, with stores stocking the sweets in Australia, Asia, Europe and North America, but the company now has its sights on the skies. We see that in the airline industry and other retail environments people are looking for new experiences and better products than everyday items, says Maarten Krikken, owner of Bar. Endeavoring to take off in the airline business does come with a learning curve, Krikken says. Its a completely different market from what we are used to. There are a lot of people involved and very specific requirements.

The Coconut Collaboratives Dessert Pots

The Coconut Collaborative is on a mission to give back to the plant and spread its coco love far, wide and high. Non-dairy, vegan and low on calorie count, the collaboratives Little Chocolate and Little Lemon dessert pots are refreshing, guilt-free treats, idealfor the health and environmentally conscious traveler. Our product has been a huge success in retail, and travel represents a good opportunity for good volumes and great marketing, says account manager James Hanbury. Having first launched in the UK, the product can now be found in France and Germany and was recently made available in a smaller to-go format with airlines in mind. Hanbury thinks the products wide consumer appeal could have airlines going coccoonutty for the little pots. Our biggest selling point and point of difference is that it caters for all, he says. I think our product represents a huge opportunity to serve everyone on the plane the same thing.

Katie is a writer for APEX Media, based in Paris, France.

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Four Snacks in Search of an Airline at the World Travel Catering and Onboard Services Expo - APEX Media

This couple uses Instagram to make a fortune traveling the world … – New York Post

This couple has turned their wanderlust into a career with the help of Instagram.

Jack Morris, 26, and Lauren Bullen, 24, travel the world while promoting brands and locations on Instagram, making six-figure salaries, according to Cosmopolitan.

They have a combined following of more than 3 million on Instagram, where they share breathtaking snaps relaxing in hammocks in the Maldives and eating pizza outside the Coliseum in Italy.

The couple, who have been dating for two years, earn up to $9,000 for a single post. According to Morris, he would not promote anything on his account for less than $3,000.

Morris, who is originally from Manchester, United Kingdom, started jet-setting around the world after buying a one-way ticket to Bangkok when he was 21 years old. Meanwhile, Bullen first started gaining followers taking photos around her home country, Australia.

They had each already been blogging their travels, gradually building up their brand portfolios, before they met while in Fiji for a job.

We got on so well from day one and were inseparable throughout the whole trip. On our last night in Fiji I asked her to come to Bali with me, she said yes and weve been together ever since! Morris wrote on his blog Do You Travel.

When not working, the couple lives together in Bali, Indonesia.

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This couple uses Instagram to make a fortune traveling the world ... - New York Post

Latin Trails Nominated in Two 2017 World Travel Award Categories – TravelPulse

PHOTO: A beautiful sunset in South America (photo courtesy of Latin Trails)

WHY IT RATES: Latin Trails has been nominated for South Americas Leading Tour Operator and South Americas Leading Boutique Cruise - Eric Bowman,TravelPulse Senior Editor

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Latin Trails is thrilled to announce its nominations for the World Travel Award 2017. This Ecuadorian DMC with more than 20 years of experience is nominated in two categories at the WTA for the 2017 edition.

The first category that Latin Trails is participating is on the South Americas Leading Tour Operator. The second category is on the South Americas Leading Boutique Cruise with its flagship yacht the Galapagos Sea Star Journey.

The industry being awarded by the WTA is getting the recognition as the best in its category either worldwide or regionally.

The World Travel Awards, known as the Oscars for the tourism and travel industry, has announced its nominees for the 2017 edition. In this opportunity, Ecuador is competing in several categories with a total of 36 nominations.

Ecuador in the last three editions of the WTA has won very important categories. For instance, in 2016 the country and its industry received 9 awards.

Some of the categories that Ecuador is running for being the South Americas Leading Destination are the beach destination with the Galapagos Islands, Cultural and Culinary destination, Green and Meeting & Conference destination. There are also some categories that the best tourism and travel companies are competing, such as the Tren Crucero in the category of South Americas Leading Luxury Train.

Finally, we invite you to vote for Latin Trails as one of the best tour and travel companies in Ecuador by clicking the following links. Sea Star Journey as the South Americas Leading Boutique Cruise Latin Trails as the South Americas Leading Tour Operator

And, also, we encourage you to vote and promote Ecuador in the other categories by registering on worldtravelawards.com/vote

SOURCE: A Latin Trails press release.

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World Travel Market brings together key players in So Paulo … – eTurboNews

More than 100 senior industry leaders, authorities, private sector executives and tourism professionals, accompanied the conversation between the leadership of the three countries which, according to the United Nations (UN), are looking at tourism as a component of sustainable development.

This was the second day of the 5th edition of WTM Latin America & 47th Braztoa Business Event as it got underway with an important political meeting between leaders of the Latin American travel industry. The Ministerial Round Table on Tourism as a Tool for Development consisted of Marx Beltro, the Brazilian Minister for Tourism, Lilian Kechichin, Uruguay's Minister of Tourism, and Alejandro Lastra, Argentina's Secretary of Tourism, in the realization of a meeting that was conceived during WTM London in November of last year.

"WTM portfolio is globally recognized for guaranteeing encounters that promote networking, business creation, and reflection regarding the industry's challenges and opportunities. Holding this meeting as one of the milestones of the fifth edition of WTM Latin America is a source of great pride for us. We know that we are contributing, in an effective way, to the industry's development", says Lawrence Reinisch, Exhibitions Director of WTM Latin America.

The secretary of the World Tourism Organization (UNWTO), Sandra Carvao, who mediated the debate, reinforced the importance of 2017, which was elected the Year of Sustainable Tourism, and highlighted the three goals that have been ever-present this year: raising awareness regarding this industry's power as a tool for sustainable development, the mobilization of the public and private sector, and mobilization with public policies changing consumer behavior.

During the meeting, the Brazilian Minister for Tourism, Marx Beltro, praised the initiatives that are being developed, in particular policies for simplifying visas, strengthening air infrastructure, with greater connectivity, and promotion of destinations, in addition to the size of Brazil's territory and the potential from the partnership with the private sector. "We are working hard on the concessions and infrastructure agenda, increasing access to the more than 60 million people who travel throughout Brazil. But the government can't resolve everything".

Marx Beltro also stressed that the country needs to use the sector as a driver of economic development "generating employment and income in local communities where tourism enterprises have already been developed". The Brazilian minister added that the industry continues to grow, even in the face of the economic challenges. "the travel industry is the only one that's swimming against the tide of unemployment."

BUSINESS GENERATION

Another highlight of the second day of WTM Latin America was the start of the highly sought after the Speed Networking sessions, in the Networking Area. This business activity was set up so that buyers have the opportunity to make the greatest possible number of contacts with exhibitors in a short space of time. The sessions contribute to the diversity of contacts and receptiveness among the investors, making the relationship between them more dynamic. "It is very important to stress that these are not conventional meetings: Speed Networking paves the way for deals that will be done later," says the Exhibitions Director of WTM Latin America, Lawrence Reinisch.

Today, approximately 400 exhibitors and 100 buyers took part of the event, including Ricardo Shimosakai, who is commercial director of the company Turismo Adaptado. "I regard it as having been a very good experience. These relationship encounters are very positive, mainly because I manage to make numerous contacts."

BRAZTOA 2017 YEARBOOK: 3% GROWTH IN THE TURNOVER

In 2016, the turnover of the companies associated with Braztoa (the Brazilian Tour Operators Association) came to a total of R$ 11.3 billion, which represents a 3% increase vis--vis the previous year. Domestic tourism was the choice of 81.4% of Brazilians during the period, as compared with 78.5% in 2015, reflecting the crisis period and the change in consumption patterns, marked by substitution of destinations, products and services. These figures are part of the Braztoa 2017 Yearbook, which is presented today by the organization's president, Magda Nassar.

In relation to the type of package sold, complete packages - those that include both the land part and the air part - remain the preferred option for most people, accounting for 60% of the choices. The number of embarkations showed a slight increase of 1%, and of the 5.12 million passengers who embarked, 4.1 million went to destinations inside Brazil. The Brazilian region that stands out the most is that of the Northeast, which accounts for 67.4% of the sales of domestic trips, followed by the Southeast with 13.7%, the South with 12.6% and the North and Centre-West regions, which together account for 6.1% of the industry's turnover.

"Our industry registered a small increase in a year full of challenges," recalled Magda. "But we recently had the announcement of a freeze of nearly 68% in the Ministry of Tourism's expenses (a R$ 321.6 million cut). Let's complain", invited the president.

The complete yearbook will be available on Braztoa's website ( http://www.braztoa.com.br ) from April 7 onwards.

PROFESSIONAL UPDATING

Continuing with the training and professional development agenda, WTM Latin America welcomed the researcher and professor from the University of So Paulo, Mariana Aldrigui, who spoke about how new generations are playing a leading role in terms of developing inspiring projects to help preserve the environment.

During the panel "Translating sustainability into business: inspiring ideas!", the specialist went as far as to challenge Brazilian students. "If countries such as the Netherlands, the United States and the United Kingdom can create gardens inside supermarkets, vests with pollution sensors that measure how often to reduce pollution, Brazil needs to get into gear and encourage people with new ideas".

Another panel that had a full crowd was the one presented by Google's tourism industry analyst, Felipe Chammas. The advertising executive presented a number of examples of productions that got thousands of hits on YouTube, applauding the fact that the consumption of travel content on the platform has increased by 200% over the last few years. "You have to think in terms of how to creatively inspire and influence these travelers. Because they are doing research and are identifying with the tips given and the experiences presented in the videos".

eTN is a media partner for WTM.

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World Travel Market brings together key players in So Paulo ... - eTurboNews

How Instagram Stars Jack Morris and Lauren Bullen Make Money … – Travel+Leisure

Ah, the honeymoon phase of a new relationship: spontaneous dates, late-night conversations... exploring Balinese waterfalls, piggy-back rides through the jungle, and breakfasts with giraffes on safari.

Okay, so some of those perks only come with a budding romance if you're Jack Morris, 26, and Lauren Bullen, 24, two travel bloggers who met in Fiji just over a year ago and have already traveled to more than 20 countries together. On top of that, they're earning six-figure salaries doing it.

Go ahead, send your significant other that passive-aggressive text message. We'll wait.

Courtesy of Lauren Bullen @gypsea_lust | Jack Morris @doyoutravel

Morris, the face of the travel blog Do You Travel, recently hosted a Q&A where he gave his 2 million Instagram followers travel and money tips and answered their burning questions about his beautiful Australian girlfriend and how they turned everyone's dream life into a reality.

In the post, he reveals he didn't go to college, cleaned carpets for a living, lived out of a backpack for four years, and got a house with Bullen in Bali last October after meeting her in March. (So basically, yes, your mother's advice on everything might be wrong.)

We met in March 2016 whilst on a job together in Fiji. We got on so well from day one and were inseperable throughout the whole trip, Morris writes of Bullen, who goes by @gypsea_lust to her 1.2 million Instagram followers and also has a blog of her own. On our last night in Fiji I asked her to come to Bali with me, she said yes and we've been together ever since!

Courtesy of Lauren Bullen @gypsea_lust | Jack Morris @doyoutravel

The pair has since traveled to more than 20 countries, and recently celebrated their one year anniversary with some PDA under a turquoise waterfall. (How else?) Right now, Morris and Bullen make up to $9,000 and $7,500 per sponsored Instagram post, respectively, according to Daily Mail Australia.

Courtesy of Lauren Bullen @gypsea_lust | Jack Morris @doyoutravel

Want to become an Instagram star in your own right? Morris gives some tips: He uses Lightroom to edit his photos, not Instagram filters. I also look at the grid and try to plan the next image to make sure it works well with the rest of my recent feed, he wrote.

To avoid crowds, he said he shoots at popular spots around one hour after sunrise. He also said he takes all photos of Lauren, and she takes all photos of him. When they're pictured together, they usually use a tripod and timer.

Courtesy of Lauren Bullen @gypsea_lust | Jack Morris @doyoutravel

Morris' feed is filled with jaw-dropping destinations, which he says he finds via word of mouth, Instagram, and research on Pinterest. The couple aims to travel to at least one new country every month (for pleasure; that's not counting work), which they select last-minute.

To learn more about his favorite (and least favorite) places, pros and cons of being an influencer, and the Instagram photo he loves most, check out Morris' post on Do You Travel.

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How Instagram Stars Jack Morris and Lauren Bullen Make Money ... - Travel+Leisure

How ‘Two Fat Americans’ Quit Their Jobs to Travel the World Without Instagram Fame or Sponsorships – Travel+Leisure

If you love to travel and have an Instagram account, chances are you've spent your fair share of time scrolling through gorgeous tropical scenes featuringequally gorgeous full-time vacationers.

And while we can appreciate an artistically shot bikini photo as much as the next personespecially when the photographers share their tips and trickswith the rest of us the truth is, sometimes it starts to feel like you need an inbox bursting with hungrysponsorsand thousand-dollar photo requeststo make your travel dreams a reality.

Enter Dean and Julie Couchey, a world traveling husband and wife teamfrom upstate New York and Pennsylvania, respectively, who quit their jobs after tying the knot and have traveled to 20 countries together before their first wedding anniversary.

The fun-loving duois dedicated to eating and drinking our way around the world (while doing some other fun things too),according to the tagline on their travel blog, Two Fat Americans. And while they do get a kick out of watching people react to their site's cheeky name, the Coucheystold Travel + Leisure there's more to it than appearances.

We wanted to think of a name that would be both funny and representative of who we are,they told T+L via email fromYogyakarta, Indonesia. Yes, we're on the larger side, but also there is a stigma in the world that Americans are just fat people who, if they do travel, only go to the tourist spots and eat at the tourist places. By having a funny, catchy name, we have hopes that it will intrigue people enough to check us out and see that we couldn't be further from that stigma. (Aside from the fat part!)

The Coucheysdefy this American stereotype byvisiting spots less traveled, and taking their quest to find the best local food very seriously: Dean, 34, is atrained chef, and Julie, 28, is a foodie and photographerwho lives to taste (and document)every bite.

The travelers have chowed down on everything from pain au chocolat in Paris and choripan con chimichurri in Argentina to gado-gado (a potato and vegetable salad with peanut sauce) in Indonesia.

But the best meal they've had so far was at 1884 by Francis Mallmann in Mendoza, Argentina.

We had an amazing grilled potato cheddar flatbread and salt poached pear with burrata for starters. For our mains we had chivito, baby goat braised in a clay oven,and a clay oven-cooked gnocchi with tomato pesto sauce,they said. The most memorable meal in the most memorable setting.

After Indonesia, the couple will head to Malaysia, Singapore, and Thailand. After that, they will make their way through Southeast Asia up to Japan, and fly from there to India and beyond.They also have three months in Europe in their plans.

But how do they manage to do all this without earning an income?

The Coucheys saved money by cutting back expenses before leaving home no Starbucks, no eating out and saving up vacation days at their respective jobs. "We were the typical Americans that had saved many many weeks of vacation and luckily we were able to get it paid out," they said.

In the future, they hope to advertise on their website,and they are open to working in restaurants along the way.

But for now, they make each dollar go a little further by using rewards programs and choosing flights wisely: Pack lightly and be okay with a cramped more affordable flight because the destination will always he much more enjoyable than the trip to get there, regardless of what your seat is like on the plane.

They also use cash back rewards and loyalty programs.

We figured since we will be staying in a lot of hotels, we will use Hotels.com because they give you onefree night after 10 nights,they said, adding that when you're spending 180 or more nights on the road like they are, the savings add up.

They have also made over $500 back so farshopping for necessary items (and hotels)through Ebates. Hotels.com is a participant, and they earn 3to6 percent cash back on those transactions, while taking advantage of special promotions. They also use a Citi Double Cash card for airline and hotel bookings, which gets them 2 percent cash back, and aCapital One Quicksilver card that gets them 1.5 percent back (with no foreign transaction fees).

They use frequent flier benefits fromStar Alliance and Air Asia, but won't tie themselves to an airline. Instead, they use deal comparison sites like Kayak and Google Flights, but make sure to check for hidden fees.

We also promote Ebates and Hotels.com on our blog, because if we can get people to sign up and through our link we get a bonus,they said. We're hoping more people sign up so that can start to add up for us.

They originally planned to travel for sixor eightmonths, or until the money ran out,but if possible, the Coucheyshope to prolong their dream. They see themselves toasting to their anniversary in July in Paris.

And as they go, their main goal is to spread the message that you too can make it happen, even without a fancy portfolio or famousInstagram account. (They currently have 449 followers.)

We want to represent the real traveler that is going to accessible places and not a world famous chef's house or staying in 5-star resorts far away from the real destinations,they said. Most of all we just want to show and tell people that you don't have to be young, beautiful, thin, fit, free spirited or whatever you think the stigma is to travel and see the world.

That goes for whatever your dream is in life. If you love it and are passionate about it, do it for you and enjoy every minute.

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How 'Two Fat Americans' Quit Their Jobs to Travel the World Without Instagram Fame or Sponsorships - Travel+Leisure

Afrofuturism Tries to Find its Footing in Virtual Reality – The Chicago Maroon

Last Friday, the Stony Island Arts Bank showcased the work of international female art collective Hyphen-Labs.Their newest project,NeuroSpeculativeAfroFeminism(NSAF), attempts to revive the aesthetic movement of Afrofuturisma magical-realistscience fiction exploration of black culture and historyby incorporating contemporary design, neuroscience, and technology to preserve black culture in the digital age.

The NSAF project is highly ambitious; it places real-world objects alongside a virtual reality (V.R.) AfroFeminism experience. Unfortunately, Fridays promised V.R.demonstration flopped; the headset would not function properly, disappointing about 30expectant attendees.

NSAFs products seek to address the daily needs of black citizens in the digital age. One such product was a pair of huge, pink door-knocker earrings that record video on command. These conspicuous earrings, the group explained, could help many black women feel more secure in their everyday life. Another innovation was a digitally-printed headscarf, inspired by traditional African headscarves. What is more, the headscarf technology combats facerecognition algorithms by overloading the software, rendering the wearer untraceable. In an age of constant surveillance, the headscarf works to make black women feel more secure.

Hyphen-Labssfeature creation was a mixed-media, chiefly V.R.neurocosmetology experience. The viewer enters a spacehalf neurosurgery bay, half hair salonwhere, the event description stated, black women pioneer brain modulation and cognitive enhancement by embedding electrodes into extensions and braiding techniques. The need for a hair salon, according to the group, stems from technology designers failure to produce headset designs that accommodate larger hair.

When Hyphen-Labs was describing the fictionalcharacterswho inhabit the neurocosmetology salon, they introduced a black woman named TechnoAfricanum-Culturist, a billion-year-old trans-human.

What is a black woman whos a trans-human? an artist rhetorically asked the audience. [It is] where your technology is inextricably linked to your self. TechnoAfricanum-Culturist, for example, reportedly holds the balance of all of the universes in her larger-than-life silver afro.

The project, however, had some striking weaknesses. Headsets continued to malfunction during the event, and the productsthough they claimed everyday utilitywere impractically niche. Hyphen-Labs, moreover, includes only one black member.

Some of Fridays attendees appeared uncomfortable.One woman in the audience later asked, in reference to the digitally printed headscarf, as women, whether white, black, Asian, we all are vulnerable, so why did you specifically choose one particular group when pretty much everyone could wear [the headscarf]?

Acknowledging that I am not a member of the target demographic, I cant judge the appropriateness of this kind of artistic creation, but the project nonetheless struck me as drawing on cultural stereotypes in dangerous ways. There is no question that black culture must be preserved and promoted, but there must be a way to express its spirit without reasserting only its most visible tropes into the conversation. It felt odd that the artists would choose to address larger social issues through capitalist consumerism and by reducing women to their cosmetic choices. I getthe unshakable feeling that a black futuristic womans larger-than-life silver afro is analogous in this situation to, say, a Jewish futuristic mans larger-than-life silver yarmulke.

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Afrofuturism Tries to Find its Footing in Virtual Reality - The Chicago Maroon

Rubio Announces 5-EP Series With Two Bone-Chilling New Tracks – Remezcla (blog)

In this musical landscape of on-demand streaming and disposable playlists for every mood and occasion, its really a blessing when an artist gives us the opportunity to slow down and really listen to their music. That is part of the beauty of Rubios new EP series. Rubio is the solo electronic project of drummer, singer, and Chilean national treasure Fran Straube, who is best known for fronting and drumming in electronic rock band Miss Garrison. Following last years self-titled debut EP, Straube has just released atwo-song EP, with promises of four more to come in 2017 through Jungla. Its a way ofexploring her sound on this project while keeping fans involved in the experience for a whole year. Plus, the strategy gives us time to fully explore each song.

The first of this series, titled R, consists of Luz and Indonesia, two songs that warrant repeated plays and engaged listening. With this new material, Straube reminds those who follow her many musical endeavors that her gift for rhythm applies to digital beats just as much as it does to analog percussion. The first Rubio EP pushed the envelope for stylish downtempo and dabbled in dembow, managing to be simultaneously cool and sultry. This new EPcito is even more experimental in some ways, and a touch more minimal. (If you must playlist these songs, slide them in between the latest Arca and Nicolas Jaar.)

If R can be taken as a kind of digital seven-inch, then Luz, featuring a vocal assist from Carlos Cabezas of seminal Chilean electronic group Electrodomsticos, is the A side. Together, the two avant savants deliver a smooth electrobolero, their smoky, intertwined vocals haunting the track like a ghost in a shell. Much like Al Sol de Noche, Straubes most recent album with Miss Garrison, the sci-fi vibes are thick here. Luz would be perfect for soundtracking a Bladerunner-style android adventure film set in present-day Santiago de Chile. Lado B Indonesia holds its own by being both more challenging and more pop. With just the right amount of auto-tune on an anthemic vocal hook, Straube becomes a transhuman chanteuse, riding a jazzy production with subtle Southeast Asian references.

Its hard not to look ahead and wonder what othersurprises the EP series will reveal. You can probably figure out what the next four EPs will be titled. The only other thing we can tell you is that, once this journey is over, all the songs will be put together as a limited physical release.

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Rubio Announces 5-EP Series With Two Bone-Chilling New Tracks - Remezcla (blog)

This dad is a genius biohacker. But he could lose his kids because of it. – Fusion

In the name of science, Rich Lee has done things to his body that most of us wouldn't dare imagine. He's implanted permanent earbudsin his ears that allow him to listen to music on the sly. He's implanted magnets in his finger and experimented with eyedrops that would allow him to see in the dark. Most recently, he installed tubes of armorunder the skin of his leg toact as a sort of built-in shin guard.

Lee is what's known as a grinder, part of a community of biohackers that use their own bodies as laboratories to push the limits of the human form. The human body, theyreason, is a machine that can be "hacked" forimprovement in the same way you might add features to a computer or a car. Lee sees himself as a mad scientist, tinkering with his own physicality in search of perfection.

But to Lee's ex-wife, his biohacking isn't just an odd hobbyit's a disturbing and potentially dangerous one that makes him a worse parent. She's arguing in court that it poses such a hazard to their kids that Lee shouldn't get custody of them.

When Lee divorced from his wife last November, they split the custody of their 9-year-old daughter and 12-year-old son. Then last month, after Lee's shin surgery,his wife filed a motionto give her full custody, citing Lee's biohacking as the primary reason.

"I stopped sharing joint physical custody," the motion says, "because Rich has chosen to expose our children to his disturbing behavior of do-it-yourself surgeries and bio-hacking."

His ex-wife did not respond to a request for comment through her attorney, but her court filings lay her position out clearly."I am disturbed by Richs self-destructive behavior," the motionreads, "and believe it has a negative impact on our children."

Lee's tinkering, in other words, isn't self-improvementit's self-mutilation. Lee counts himself among the camp of hackers and scientists who don't necessarily view the human body in its natural form as better. Their growing contingency, though, faces a stiff opposition from a majority of people who feel messing with nature is aslippery slope.

When he's not playing mad scientist, Lee manages a warehouse for a packaging sales firm in southwestern Utah. He got into biohacking back in 2008. He was flipping through old magazines left behind by his recently deceased grandmother, and found himself upset by headlines from decades past promising things like the end of disease andeternal life.

"I was upset at futurism," he told me. "All these predictions just never came true."

If Lee wanted to live in a transhumanist utopia, he decided he was going to have to make it for himself.

He started smalla magnet in his finger,an RFID chip in his hand. Over the years, Lee's experiments playing Frankenstein with his own body became increasingly extreme. He documented them on YouTube,turninghim into a fixture of the grinder community.His latest project in development is the Lovetron9000, an implant he hopes will turn his man parts into a bionic, vibrating penis.

"Making implants and other kinds of mad science ismy passion in life," Lee told me. "And my kids have always been really proud of it."

According to her legal filing, Lee's ex-wife had always been disturbed by her husband's surgeries, but she says they became more extreme recently.

"He has gotten several implants this past year and they are increasingly more invasive and dangerous," his ex-wife's motion reads. "It also concerns me that he is dismissive of the impact his self-surgeries have on the children. He posts them on social media and YouTube; our kids can easily access either."

Lee's ex-wife argues that exposing their kids to the sometimes gruesome world of DIY implants is not good for the kids.

In addition to restricting custodyto just visitation rights, her motion asks the court to bar Lee from "involving the children in or exposing the children to his bio-hacking/trans-human/grinder lifestyle and activities."

But Lee argues that his kids have always been curious and enthusiastic about his strange hobby. He doesn't let his kids see the grizzly stuff. And his kids, he said, love bragging to friends about their "cyborg dad."

Horrified at the thought of losing custody of his kids, Lee started a GoFund me campaign to raise money for a lawyer, asking people to "help cyborg Dad regain custody."

"I strongly believe that one's body is theirs to do what they want with. I choose to customize mine through various technological interventions.," he wrote on his GoFund me campaign page. "That does not make me an unfit parent and shouldn't make my kids love me less. I fear that the courts system in my small conservative town will not understand that parents being into body modification and biohacking ARE NOT FORMS OF CHILD ABUSE."

So far, he's raised more than $6,000 and sparked outrage among the biohacker community. In a time when technophobia is in the zeitgeistwhen Americans are wary of the effects of genetic engineering and other sci-fi sounding advancementsit's easy to view Lee's case as a referendum on biohacking itself. Implanting armor into your shins doesn't just make you audacious and perhaps a little wackyit could makeyou unfit to be a parent to your kids.

"I believe in a person's right to augment their body however they want," Lee told me. "If one parent is trans or gets a tattoo or whatever, it doesn't change their ability to love a kid."

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This dad is a genius biohacker. But he could lose his kids because of it. - Fusion

Hyperion Research: Supercomputer Growth Drives Record HPC Revenue in 2016 – HPCwire (blog)

FRAMINGHAM, Mass., April 7, 2017 Worldwide factory revenue for the high-performance computing (HPC) technical server market grew 4.4% in full-year 2016 to a record $11.2 billion, up from $10.7 billion in 2015 and from the previous record of $11.1 billion in exceptionally strong 2012, according to the newly released Hyperion Research Worldwide High Performance Technical Server QView. Hyperion Research is the new name for the former IDC HPC group.

Each quarter for the last 27 years, Hyperion Research analysts have conducted interviews with major hardware original equipment manufacturers (OEMs) in the technical computing space to gather information on their quarterly sales. Specifically, Hyperion collects data on the number of HPC systems sold, system revenue, system average selling price (ASP), the price band segment that a system falls into, architecture of the system, average number of processor packages per system, average number of nodes for each system sold, system revenue distribution by geographical regions, the use of coprocessors, and system revenue distribution by operating systems. We complement this supply-side data with extensive and intensive worldwide demand-side surveys of HPC user organizations to verify their HPC resources and purchasing plans in detail.

The 2016 year-over-year market gain was driven by strong revenue growth in high-end and midrange HPC server systems, partially offset by declines in sales of lower-priced systems.

Fourth Quarter 2016

2016 fourth-quarter revenues for the whole market grew 7.4% over the prior-year fourth quarter to reach $3.1 billion, while Supercomputers segment fourth-quarter revenues were up 45.6% over the same period in 2015. Hyperion Research expects the worldwide HPC server market to grow at a healthy 7.8% rate (CAGR) to reach $15.1 billion in 2020.

HPC servers have been closely linked not only to scientific advances but also to industrial innovation and economic competitiveness. For this reason, nations and regions across the world, as well as businesses and universities of all sizes, are increasing their investments in high performance computing, said Earl Joseph, CEO of Hyperion Research. In addition, the global race to achieve exascale performance will drive growth in high-end supercomputer sales.

Another important factor driving growth is the market for big data needing HPC, which we call high performance data analysis, or HPDA, according to Steve Conway, Hyperion Research senior vice president for research. HPDA challenges have moved HPC to the forefront of R&D for machine learning, deep learning, artificial intelligence, and the Internet of Things.

Vendor Highlights

The Hyperion Research Worldwide High-Performance Technical Server QView presents the HPC market from various perspectives, including by competitive segment, vendor, cluster versus non-cluster, geography, and operating system. It also contains detailed revenue and shipment information by HPC models.

For more information about the Hyperion Research Worldwide High Performance Technical Server QView, contact Kevin Monroe at kmonroe@hyperionres.com.

About Hyperion Research

Hyperion Research is the new name for the former IDC high performance computing (HPC) analyst team. IDC agreed with the U.S. government to divest the HPC team before the recent sale of IDC to Chinese firm Oceanwide.

Source: Hyperion Research

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Hyperion Research: Supercomputer Growth Drives Record HPC Revenue in 2016 - HPCwire (blog)

Smallest Dutch supercomputer – Phys.org – Phys.Org

April 6, 2017 A team of scientists from the Netherlands has built a supercomputer the size of four pizza boxes. The Little Green Machine II has a computing power of more than 10,000 ordinary PCs. Credit: Simon Portegies Zwart (Leiden University)

A team of Dutch scientists has built a supercomputer the size of four pizza boxes. The Little Green Machine II has the computing power of 10,000 PCs and will be used by researchers in oceanography, computer science, artificial intelligence, financial modeling and astronomy. The computer is based at Leiden University (the Netherlands) and developed with help from IBM.

The supercomputer has a computing power of more than 0.2 Petaflops. That's 200,000,000,000,000 calculations per second. Thereby this supercomputer equals the computing power of more than 10,000 ordinary PCs.

The researchers constructed their supercomputer from four servers with four special graphics cards each. They connected the PCs via a high-speed network. Project leader Simon Portegies Zwart (Leiden University): "Our design is very compact. You could transport it with a carrier bicycle. Besides that we only use about 1% of the electricity of a similar large supercomputer."

Unlike its predecessor Little Green Machine I the new supercomputer uses professionalized graphics cards that are made for big scientific calculations, and no longer the default video cards from gaming computers. The machine isn't based on the x86 architecture from Intel anymore either, but uses the much faster OpenPower architecture developed by IBM.

Astronomer Jeroen Bdorf (Leiden University): "We greatly improved the communication between the graphic cards in the last six months. Therefore we could connect several cards together to form a whole. This technology is essential for the construction of a supercomputer, but not very useful for playing video games."

To test the little supercomputer the researchers simulated the collision between the Milky Way and the Andromeda Galaxy that will occur in about four billion years from now. Just a few years ago the researchers performed the same simulation at the huge Titan Computer (17.6 petaflops) at Oak Ridge National Laboratory (USA). "Now we can do this calculation at home," Jeroen Bdorf says, "That's so convenient."

Little Green Machine II is the successor of Little Green Machine I that was built in 2010. The new small supercomputer is about ten times faster than its predecessor which is retiring as of today. The name Little Green Machine was chosen because of its small size and low power consumption. In addition, it is a nod to Jocelyn Bell Burnell who discovered the first radio pulsar in 1967. That pulsar, the first ever discovered, got nicknamed LGM-1 where LGM stands for Little Green Men.

Explore further: China to develop prototype super, super computer in 2017

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Supercomputer Sales Drove 2016 HPC Market Up to Record $11.2 Billion – HPCwire (blog)

A 26.2 percent jump in supercomputer spending helped lift the overall 2016 HPC server segment by 4.4 percent according to a brief report released by Hyperion Research yesterday. The big drag on growth was a 19.3 percent decline in sales of departmental HPC servers. Nevertheless, the overall HPC server market set a new record at $11.2 billion, up from $10.7 billion in 2015, and surpassing 2012s high water mark of $11.1 billion.

Hyperion may provide more complete numbers for the full year at the HP User Forum being held in Santa Fe, NM, in two weeks. Hyperion is the former IDC HPC group which has been spun out of IDC as part of its acquisition by companies based in China (See HPCwire article, IDCs HPC Group Spun out to Temporary Trusteeship).

The 2016 year-over-year market gain was driven by strong revenue growth in high-end and midrange HPC server systems, partially offset by declines in sales of lower-priced systems, according to the Hyperion release. Brief summary:

HPC servers have been closely linked not only to scientific advances but also to industrial innovation and economic competitiveness. For this reason, nations and regions across the world, as well as businesses and universities of all sizes, are increasing their investments in high performance computing, said Earl Joseph, CEO of Hyperion Research. In addition, the global race to achieve exascale performance will drive growth in high-end supercomputer sales.

Another important factor driving growth is the market for big data needing HPC, which we call high performance data analysis, or HPDA, according to Steve Conway, Hyperion Research senior vice president for research. HPDA challenges have moved HPC to the forefront of R&D for machine learning, deep learning, artificial intelligence, and the Internet of Things.

Getting use to the new Hyperion name may take awhile, but its senior members, all from IDC, say there should be little change, at least in the near-term. Below is the companys self-description.

Hyperion Research is the new name for the former IDC high performance computing (HPC) analyst team. IDC agreed with the U.S. government to divest the HPC team before the recent sale of IDC to Chinese firm Oceanwide. As Hyperion Research, the team continues all the worldwide activities that have made it the worlds most respected HPC industry analyst group for more than 25 years, including HPC and HPDA market sizing and tracking, subscription services, custom studies and papers, and operating the HPC User Forum. For more information, see http://www.hpcuserforum.com.

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TalkSPORT Super Computer predicts Tottenham end of season finish – Football Insider

6th April, 2017, 10:51 PM

By Harvey Byrne

A Super Computer tasked with the job of predicting the final Premier League table has placed Tottenham in second place.

Popular radio station TalkSPORThave provided an April update on their regular feature where they aim to discover the end of season results by feeding data into their prediction machine.

Now, the computer has tipped Spurs to achieve a second place finish in this seasons Premier League, which is the position they are currently occupying.

Mauricio Pochettinos side still have to travel to Chelseas Stamford Bridge alongside home fixtures against Arsenal and Manchester United before the campaigns end in eight matches time.

A second place finish would mark progression for the Tottenham team after they finished in third place in the previous season.

However, many associated with the north London club will still have their eyes set on a title challenge with just seven points currently separating them from league leaders Chelsea.

Other noteworthy placings made by the TalkSPORT machine are Tottenhams fierce rivals Arsenal in fourth, which sees them continue their 20-year consecutive streak of finishing in the top four.

Meanwhile, current third placed team Liverpool have been predicted to finish as low as sixth.

In other Tottenham news, here is Spurs best possible line-up to face Watford at the weekend.

Weve launched a<>exclusively for your club. Like Us on Facebook byclicking hereif you want 24/7 updates on all Tottenham breaking news.

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TalkSPORT Super Computer predicts Tottenham end of season finish - Football Insider

LOLCODE: I Can Has Supercomputer? – HPCwire (blog)

What programming model refers to threads as friends and uses types like NUMBR (integer), NUMBAR (floating point), YARN (string), and TROOF (Boolean)? That would be the internet-meme-based procedural programming language, known as LOLCODE. Inspired by lolspeak and the LOLCAT meme, the esoteric programming language was created in 2007 by Adam Lindsay at the Computing Department of Lancaster University.

Now a new research effort is looking to use the meme-based language as a tool to teach parallel and distributed computing concepts of synchronization and remote memory access.

Its a common complaint in high-performance computing circles: computer science curricula dont give sufficient attention toparallel computing, especially at the undergraduate level. In this age of multicore ubiquity, the need for parallel programming expertise is even more urgent. Is there a way to make teaching parallel and distributed computing more approachable? Fun even?

Thats the focus of the new research paper from David A. Richie (Brown Deer Technology) and James A. Ross (U.S. Army Research Laboratory), which documents the duos efforts to implement parallel extensions to LOLCODE within a source-to-source compiler sufficient for the development of parallel and distributed algorithms normally implemented using conventional high-performance computing languages and APIs.

From the introduction:

The modern undergraduate demographic has been born into an internet culture where poking fun at otherwise serious issues is considered cool. Internet memes are the cultural currency by which ideas are transmitted through younger audiences. This reductionist approach using humor is very effective at simplifying often complex ideas. Internet memes have a tendency to rise and fall in cycles, and as with most things placed on the public internet, they never really go away. In 2007, the general-purpose programming language LOLCODE was developed and resembled the language used in the LOLCAT meme which includes photos of cats with comical captions, and with deliberate pattern-driven misspellings and common abbreviations found in texting and instant messenger communications.

The researchers have developed a LOLCODE compiler and propose minor language syntax extensions to the LOLCODE that create parallel programming semantics to enable the compilation of parallel and distributed LOLCODE applications on virtually any platform with a C compiler and OpenSHMEM library.

They are targeting the inexpensive Parallella board, as it an ideal educational or developmental platform for introducing parallel programming concepts.

We demonstrate parallel LOLCODE applications running on the $99 Parallella board, with the 16-core Adapteva Epiphany coprocessor, as well as (a portion of) the $30 million US Army Research Laboratorys, they write.

Since its 2007 launch, LOLCODE development has occurred in spurts with activity tending to occur in early April. See also: I can has MPI, a joint Cisco and Microsoft joint Cross-Animal Technology Project (CATP) that introduced LOLCODE language bindings for the Message Passing Interface (MPI) in 2013.

Learn to LOLCODE at http://lolcode.codeschool.com/levels/1/challenges/1

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LOLCODE: I Can Has Supercomputer? - HPCwire (blog)

In the early 80s, CIA showed little interest in "supercomputer" craze – MuckRock

April 6, 2017

As you can see from my letter, CIA has no use for a supercomputer now or in the immediate future.

In 1983, cybermania would grip the nation: The movie WarGames is released over the summer, becoming a blockbuster hit for the time and intriguing President Ronald Reagan enough to summon his closest advisors to help study emerging cyberthreats and ultimately pass the first directive on cybersecurity. But according to declassified documents, made fully public thanks to MuckRocks lawsuit, one intelligence agency made a hard pass on the computer craze.

Other agencies entreated William J. Caseys Central Intelligence Agency to get involved. The National Security Agency was convening some of the nations best and brightest to develop a strategy for staying on top of the processing arms race .

In fact, the year before, the White House itself had sent Casey a memo asking that he designate someone to weigh in on supercomputer R&D policies:

But while Casey acknowledge that supercomputers were really important and he was flattered that other agencies picked the CIA to be on their team, it just wasnt something he felt comfortable devoting agency resources on :

In fact, not only did the agency not want to be part of the federal supercomputer club, in a 1983 survey it said it didnt own or have access to a supercomputer , nor did it have plans to start using them:

Why the apparent lack of concern? Maybe it had to do with an undated, unsourced (and possibly culled from public sources) report that found the U.S. cybercapabilities were still years ahead of the real threat: Russia.

But at some point, the director appears to have conceded that, for better or worse, supercomputers were not yet another fad and hed be start figuring out what exactly they were all about. Two memos from 1984 show his vigorous interest in getting up to speed on the subject.

The first response came regarding a memo on the increasing Japanese advantage when it came to building out Fifth Generation super computers .

The second memo was after he requested a copy of a staffers Spectrum Magazine, which IEEEs monthly magazine. Apparently, the director had a legendary, perhaps even alarming, appetite for reading materials.

The NSAs presentation of supercomputers is embedded below.

Image via 20th Century FOX

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In the early 80s, CIA showed little interest in "supercomputer" craze - MuckRock

Your chance to become a supercomputer superuser for free – The Register

Accurate depiction of you after attending the lectures. Pic: agsandrew/Shutterstock

HPC Blog The upcoming HPC Advisory Council conference in Lugano will be much more than just a bunch of smart folks presenting PowerPoints to a crowd. It will feature a number of sessions designed to teach HPCers how to better use their gear, do better science, and generally humble all those around you with your vast knowledge and perspicacity.

The first "best practices" session will feature Maxime Martinasso from the Swiss National Supercomputing Center discussing how MetroSwiss (the national weather forecasting institute) uses densely populated accelerated servers as their basic server to compute weather forecast simulations.

However, when you have a lot of accelerators attached to the PCI bus of a system, you're going to generate some congestion. How much congestion will you get and how do you deal with it? They've come up with an algorithm for computing congestion that characterises the dynamic usage of network resources by an application. Their model has been validated as 97 per cent accurate on two different eight-GPU topologies. Not too shabby, eh?

Another best practice session also deals with accelerators, discussing a dCUDA programming model that implements device-side RMA access. What's interesting is how they hide pipeline latencies by over-decomposing the problem and then over-subscribing the device by running many more threads than there are hardware execution units. The result is that when a threat stalls, the scheduler immediately proceeds with the execution of another threat. This fully utilises the hardware and leads to higher throughput.

We will also see a best practices session covering SPACK, an open-source package manager for HPC applications. Intel will present a session on how to do deep learning on their Xeon Phi processor. Dr Gilles Fourestey will discuss how Big Data can be, and should be, processed on HPC clusters.

Pak Lui from Mellanox will lead a discussion on how to best profile HPC applications and wring the utmost scalability and performance out of them. Other session topics include how to best deploy HPC workloads using containers, how to use the Fabriscale Monitoring System, and how to build a more efficient HPC system.

Tutorials include a twilight session on how to get started with deep learning (you'll need to bring your own laptop to this one), using EasyBuild and Continuous Integration tools, and using SWITCHengines to scale horizontally campus wide.

Phew, that's a lot of stuff... and it's all free, provided you register for the event and get yourself to Lugano by 10 April. I'll be there covering the event, so be sure to say hi if you happen to see me.

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Your chance to become a supercomputer superuser for free - The Register

Stem-cell therapy is poised to disrupt the Tommy John epidemic in baseball – Quartz

For about half a decade, its been something of an open secret in baseball that playerspitchers especiallyregularly undergo stem-cell therapy to stave off surgeries and lost playing time. Its a cutting-edge medical procedure, done by everyone from high-school standouts to major-league all-stars. Its rarely discussed by players, or by their coaches, parents, doctors, or employers.

So when the Los Angeles Angels went public in 2016 with the news that first Andrew Heaney and then Garrett Richards were undergoing stem-cell therapy for torn ulnar collateral ligaments (UCLs), it was both anticlimactic and a revelation. For the first time, baseball pitchers and their employers were openly admitting trying this novel procedure that, while fairly well-proven anecdotally, has yet to be validated by any well-designed scientific study.

By now, that so-called Tommy John surgery for a torn or damaged UCL has become a rite of passage for the top-flight professional baseball pitcher is a cliche of sports punditry. Every young arm that can fold and then unfold itself into tortuous patterns that facilitate throwing baseballs at 95 miles per hour or faster is bound for the knife, once those upper body contortions inevitably tear the tissue on the inside of their elbows connecting their upper and lower arms, the UCL.

The first Tommy John surgery (or more properly, UCL reconstruction) was performed in 1974 by the orthopedic surgeon Frank Jobe, then the team physician for the Los Angeles Dodgers, on the eponymous pitcher. It was a great success; Tommy John came back to pitch 14 more years in the pros, racking up 164 wins with four different teams.

TJ surgery is fairly straightforward: the connective tissue that makes up the UCL is either replaced with a tendon taken from elsewhere in the patients own body or from the donated tissue of a cadaver.

Nevertheless through the mid-1970s and into the 80s, TJ was something of a rarity; just a handful of baseball players underwent that particular knife. In the 1990s the numbers started to tick up, and then in the 2000s, they exploded. From 1995 to 2005, there was an average of 28 TJ surgeries per year across all levels of pro baseball; from 2005 to 2015, there was an average of 84 TJ surgeries per year.

Then something strange happened. In 2016, the total number of TJ surgeries performed dropped to 90, from 127 the year before, a 30% decline. Only one other year in Tommy John history, 2008, saw such a precipitous drop from the previous year. By 2009, TJ numbers were back to 2007 levels; obviously it remains to be seen whether 2017 will look more like 2015 or more like last year. But the data suggest that if TJ surgery numbers are in fact starting to trend downward, it might have something to do with the rise of stem-cell therapy.

What makes stem cells unique is that they are whats called undifferentiated; they can become other specialized cells depending on the bodys need at the time. There are two types of human stem cells, embryonic and adult. Embryonic stem cells come from a very early-stage embryo; these are what you likely think of when you hear the term stem cellstheyre at the center of one of most exciting fields of medical science research today. Embryonic stem cells are now used or are being studied for a shockingly wide range of applications, from Alzheimers and autism to vision impairment and infertility. However, thanks to the religious right-driven opposition to the harvesting, study, and use of embryonic stem cells, theyve been mired in controversy in the US.

On the other hand, the use of adult stem cellswhich can be harvested from bone marrow, fat, or blood of any person of any age (the name is a bit misleading)is widely accepted by both the medical community and politicians. They have less range, so to speak, than embryonic stem cells; they are primarily to repair and replace damaged tissue in the area they are found. That makes them just about perfect for repairing a torn UCL.

The first pro baseball player known to have undergone stem-cell therapy for a UCL weakness was Bartolo Colonand he was basically forced into talking about it. Following a long run of success culminating with a Cy Young Award season in 2005, Colon had four frustrating years racked with injury and ended up unsigned after 2009. He took a year off to recuperate and in spring of 2011, he was back, signed with the New York Yankees and feeling good. Serge Kovaleski, an investigative reporter with the New York Times, started digging into how Colon had made his comeback, and uncovered the name of Joseph Purita, an orthopedic surgeon and stem-cell therapy pioneer.

As Purita tells it, there was nothing illegal or nefarious about the work hed done on Colon; there was just never a plan to broadcast it, either. Then, he recalls, the Times called me up and said were going to write a story whether or not. So, Purita offered details. In April 2010, he told the paper, a team of Dominican doctors used stem-cell therapy to help repair Colons ligament damage and torn rotator cuff.

Colons recovery was a resounding success. Hes been an all-star twice, is the current active leader in major league wins, and, at age 44, is signed to a $12.5 million contract to be the Atlanta Braves number two starter for the 2017 season.

I cant give names but there are some professionalsBut instead of thrusting stem-cell therapy into the mainstream, the Colon incident forced it to stay underground. The treatment was not well understood at that point, and the circumstancesthat it was done offshore, that it was unearthed by investigative reporting, and that, in 2012, Colon was suspended for 50 games for testing positive for testosterone useclouded public opinion on it. Many were convinced Colon had gotten performance-enhancing drugs in the Dominican Republic. Purita denies this vociferously, and MLB inquiries back him up.

The upshot is that every doctor I spoke to who studies and performs stem-cell therapy for torn-ligament repair says some version of the same thing: I cant give names but there are some professionals who have come in for treatment, says Joshua Dines, an orthopedic surgeon at New Yorks Hospital for Special Surgery, and an assistant team physician for the New York Mets.

Purita says that since Colon, hes worked with some players that had team approvaland some just come on their own, but none wanted to go public about the procedure.

If use of your arm is mostly limited to spreadsheet jockeying and lifting forkfuls of pasta or salad from plate to maw, TJ is no big dealin that case, youre ready to go back to work in six weeks. But if you throw a ball at top speed past another pro athlete for a living, youre going to be out of commission for 18 months or more as you regain strength in your money arm.

And money is the (post) operative word. In 2016 alone, MLB teams lost nearly $60 million in player value because they had to fulfill dozens of contracts of players recovering from Tommy John. Thats nearly enough to field an entire pro teamdefinitely enough to roster a top-of-league pitching staff. And that $60 million doesnt come close to accounting for the losses suffered by players who had to undergo the knife during the last year of a contract, and found themselves released by their previous teams with no new offers on the table while they recovered.

There was never going to be a way to prevent the need for Tommy John surgeries. Baseball players throw far too hard, with far more breaking pitches, starting at far too young an age, to realistically stop UCLs from tearing (though all sports medicine experts do now warn coaches and parents to keep kids and teens at low pitch counts). The alternative was always going to be something that could cure ligament tearsbut better than TJ surgery, with a faster recovery time.

Everything weve seen in the past decade or so suggests stem-cell therapy is exactly that. At this point, platelet-rich plasma (PRP) injections are common first-line defenses against UCL injuries. The procedure entails harvesting PRP from the player and injecting it into the injured part of the body. PRP is dense with proteins specialized for injury repair.

You can think of these injections as a precursor to stem-cell therapy; both are considered biologic treatments and entail wielding the bodys own weapons against injury. Many of the doctors now doing stem-cell therapy started off with PRP procedures. When baseball players have a torn ligament, they typically try PRP first. If that fails, its Tommy John time.

Everyone in the field says that at this point PRP is last decades technologyExcept, everyone in the field says that at this point PRP is last decades technology, more than ready to be replaced by stem-cell therapy, which does much the same thing but better. Adult stem cells essentially are there for the very purpose of tissue repair. Why not take them from a part of the body thats all good, and send them to a region where reinforcements are desperately needed?

Dines says that in his own practice, hes been able to cut down the need for Tommy John surgery by about a third, thanks to his reliance on stem-cell therapy. He doesnt believe that the procedure will lower the number of players that have to have TJ, but it will limit the number of overall TJ surgeriesbecause at this point, many pitchers have to get the surgery twice in their career. Dines says stem-cell therapy can get 15- or 16-year-old pitchers through their first partial tear. They may still need to get a full TJ surgery by age 24, but avoiding that first one is still a huge victory. (A growing number of middle-age first-time TJ patients could also explain the overall drop in Tommy John surgeries.)

Purita is even more optimistic. While most orthopedic surgeons say that, right now, stem-cell therapy is effective on partial, but not full, ligament tears, Purita is confident his version can handle any UCL. He sent Quartz a photo showing a patientan MLB pitcher who wishes to remain anonymous, Purita sayswho had a full UCL tear in November 2011 and, after receiving stem-cell therapy at Puritas clinic, made a full recovery by February 2013.

You never say something replaces something else entirely, Purita says. Stem-cell therapy is not going to replace every case [of Tommy John], but it could probably replace the majority of cases.

Talk to anyone who knows the field and theyll rattle off the same reasons why stem-cell therapy for UCL tears isnt already the standard of care: One reason is that, relative to the population, the number of UCL tear patients is extremely small, which means theres only a tiny pool from which to draw potential study participants. Two, a trial for a new medical treatment is typically only considered well-designed if the subjects are blindthat is, they dont know if they are getting the real treatment or a placebo. But what kind of team or player is going to risk a million-dollar arm on a properly designed study where theres a 50% chance that the injury gets a placebo?

Thats not to say that this is some sort of back-alley procedure. Its performed by some of the most prestigious orthopedic surgeons and medical research centers in the US, and the US Food and Drug Administration approves its use: US doctors are allowed to harvest a persons stem cells and use those cells to treat that same person, as long as you dont manipulate (e.g. genetically modify) the cells.

Someone making $20 million a year is not going to do something he hasnt checked out wellThe lack of literature on the procedure hasnt exactly inspired the confidence of players and teams to go public with their decision to pursue it; nor does the fact that the procedure for years had, as Dines puts it, a bad rap[it] would get lumped in with things that were illegal. There was this specter of cheating. But Dines, and others, say thats changing.

The needle is moving towards this being a valid way of treating things, says Purita. People are starting to recognize that someone making [or risking] $20 million a year is not going to do something he hasnt checked out well.

Amadeus Mason, a sports medicine and biologics expert at Emory University, compares stem-cell therapy today to Tommy John in the 1980s. It was, Okay, were going to try this and see, says Mason, who trained with orthopedic surgeon James Andrews. (Andrews is the Michael Jordan of ligament repairhes saved the arms and careers of some of the greatest pitchers in major league baseball history.) There wasnt a big fanfare going in when players started with Tommy John surgeries, Mason says, but when players came back to pitch [there] was. Same thing here.

Mason thinks stem-cell therapy hasnt quite reached the inflection point, but it is near. Here, too, he sees a comparison with Tommy John: It took a while for them to perfect the procedure so that more and more doctors could do the surgery and reproduce the results well.

Right now, Mason says, there is a relatively small handful of doctors who can do stem-cell therapy for UCL tears, but that list is growing rapidly. For example, the annual conference of the Orthobiologic Institutea professional organization for regenerative medicine researchers and practitionersstarted in 2009 with 20 or so doctors; last years event had nearly 1,000.

Some players can throw faster after they have the surgeryThe Angels didnt want to talk to me about why they decided to go public with Heaney and Richards stem-cell therapies. Perhaps thats because Heaneys, on May 2, 2016, was unsuccessful. The 25-year-old former first-round draft pick underwent Tommy John surgery in July of that year after failing to regain strength in his left arm. Hell miss the entire 2017 season, setting back a promising young career.

Richards had his stem-cell procedure just 14 days after Heaney. So far, it seems to have worked. He didnt return to pitch in 2016, but in spring training this year, he was throwing nearly 100 miles per hour. Probably the Angels best starting pitcher, Richards will take the mound on April 5, and all eyes will be on his right throwing armand on his face, to see if it is registering any pain.

If Richards stays healthy this yearand next year, and the year after thathe could become something like the 21st-century Tommy John. Every team will have a stem-cell therapy expert on its medical staff, or at least one on speed dial. Careers will be saved, and so will millions of dollars.

But wider use of stem-cell therapy also will force the MLB to confront an interesting potential side effect of the procedure. Some players can throw faster after they have the surgery, says Purita. By definition, its making the performance better. Right now, major league baseball does not include stem-cell therapy in its list of banned performance enhancers (pdf). But what happens when a baseball player, perhaps a fringe pitching prospect in the low minors, feels some elbow pain one day and gets an MRI, and is diagnosed with nothingbut decides to get stem-cell therapy anyway, since it could give him an extra four miles per hour on his fastball?

The MLB will have a decision to make: To accept potential competitive imbalances to save young arms, or to seek to preserve a level playing field (or even just the fiction of one) at the cost of some of the games best players. The question is all but inevitable.

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Stem Cell Therapy for Autism Shows Promise – WebMD – WebMD

April 6, 2017 -- A stem cell treatment for autism shows promise, according to a new study, but the investigators and other experts emphasize that the therapy is still in the early stages and much more research is needed.

The Duke University study included 25 children, ages 2-6, with autism and assessed whether a transfusion of the youngsters' own umbilical cord blood containing rare stem cells would help treat their autism, CNN reported.

Behavioral improvements were reported in 70 percent of the patients, according to the study in the journal Stem Cells.

A second, larger trial is now underway and the researchers hope they will find a long-term treatment for autism, CNN reported.

Some experts say many unanswered questions remain and the study authors agree much more work needs to be done. This initial trial was a safety study, meaning doctors and the children's families knew the therapy was being administered and there was no comparison between treated and non-treated children.

"Some children, who were not speaking very much, had big increases in their vocabulary and their functional speech," study author Dr. Joanne Kurtzberg, head of the Robertson Clinical and Translational Cell Therapy Program, told CNN.

"Many children were able to attend to play and have meaningful communication in a way that they weren't before. Some children had less repetitive behaviors than they did when they came onto the study," Kurtzberg said.

"The study was very encouraging. We did see positive results. However, it did not have a comparison group, which is very important in establishing whether a treatment is actually effective," study author Dr. Geraldine Dawson, director of the Duke Center for Autism and Brain Development, told CNN.

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Study: heart failure stem cell therapy safe, shows early signs of effectiveness – The San Diego Union-Tribune

A stem cell treatment for heart failure patients is safe and shows early signs of effectiveness, according to a study published Wednesday.

The study was conducted by Japanese researchers in 27 patients, who received transplants of stem cells taken from their own thigh muscles. There were no major complications, and most patients showed considerable improvement in their symptoms.

The study was published in the open-access Journal of the American Heart Association. Dr Yoshiki Sawa of Osaka University Graduate School of Medicine was the senior author. It can be found at j.mp/stemheart.

However, two San Diego cardiologists who do stem cell research on heart disease cautioned that similar clinical trials have shown promise over the years, only to fail at the end for various reasons. There is no approved stem cell therapy for heart failure.

So while the trial itself appears to be well-conducted, the researchers are very far from actually proving their treatment is effective, said Dr. Richard Schatz of Scripps Health and Dr. Eric Adler of UC San Diego School of Medicine.

For one thing, the trial was small, they said, and larger trials are where the most rigorous scientific evaluations are made.

These early trials have looked beneficial in the past, Adler said. When we do the larger trials, the results are more equivocal.

Adler said the signs of efficacy in this trial are modest. For example, the change in ejection fraction, a measurement of efficiency in pumping blood, rose from 27 percent to 30 percent in 15 of the 27 patients. Their heart failure was associated with a lack of blood flow, or ischemia. The remaining non-ischemic patients actually had a slight decline.

The entire field of stem cell and regenerative therapy for heart disease has been a disappointment to date, Schatz said.

Weve been at it for 20 years now, and we dont have a product or a positive (late-stage) trial, so that tells you pretty much everything you need to know, he said. Its not for lack of trying or billions of dollars invested. Its just very, very difficult.

The cardiac field has had more success with other technologies, such as cardiac stents. Schatz is the co-inventor of the first stent.

In the study, the researchers acknowledge that previous attempts had only been modestly effective. They devised a method of producing sheets of muscle stem cells and attaching them to the inner layer of the sac that encloses the heart, a layer that rests directly on the heart surface.

The stem cell sheets stimulate healing by producing chemicals that stimulate cardiac regeneration, the study said. The cells themselves dont survive in the long term, but by the time they die they have served their purpose.

Loss of function

Heart failure is a progressive disease in which the heart gradually loses its ability to pump blood. This can be triggered by a heart attack or any other cause that damages the heart muscle.

When damaged heart muscle is replaced with scar tissue, as often happens, the heart loses pumping capacity. It becomes overstressed, and its output of blood declines. This limits the patients ability to engage in intensive physical activity. In advanced cases, patients may become bedridden.

Existing treatments include drugs and LVAD units, which take over some of the hearts function to relieve stress. Some drugs may help the heart work more efficiently, but none have been shown to improve heart failure by actually regenerating lost heart muscle.

Stem cell therapy is tested in patients who havent responded well to other treatments. Trials have been and are being conducted in San Diego area hospitals.

Scripps Health has been testing a cardiac stem cell therapy from Los Angeles-based Capricor. The cells, taken from donor hearts, are injected into the coronary artery, where they are expected to settle in the heart and encourage regrowth.

UC San Diego is testing a heart failure therapy from Teva Pharmaceutical Industries. It consists of bone marrow derived mesenchymal precursor cells. These can give rise to several different cell types, including muscle cells.

And many other trials are going on throughout the country and internationally.

Adler and Schatz said theres reason for optimism in the long run, as technologies improve.

Just because the other trials have been negative doesnt mean this technique wont be beneficial, Adler said. Its just too early to tell.

That said, Schatz emphasized that the nature of the three-phase clinical trial process means that the show-stoppers for a treatment typically appear late.

Tighter standards needed

Clean trials trials where we all agree that this is the patient population we want to look at, are needed, he said.

For example, heart failure comes in two types, he said. Ischemic heart failure is caused by heart attacks and blocked arteries, which impede blood flow. Non-ischemic heart failure can be caused by damage from diseases, such as a virus.

Non-ischemics can be younger people, in their 20s and 30s, while the ischemic patients are older. Mixing those patient groups in a single trial is a mistake, he said.

Theyre different animals, Schatz said.

Another pitfall is failing to screen carefully enough to enroll only patients likely to benefit, Schatz said.

You can have a patient who has chest pain, and coronary disease just incidentally, he said.

His shoulder or chest pain is from a virus. So he goes into the trial and gets a placebo injection in his arm of cortisone, and his arm pain goes away. And because hes in that placebo group, hes counted as a success the pain went away. It has nothing to do with his heart. Thats an extreme example, but we actually saw that happen.

In a failed gene therapy trial for heart disease, some patients apparently had received the injection in the wrong location, missing the heart muscle, Schatz said.

You assume they got the gene, but they didnt, Schatz said. The study was negative, and thats why I think it was negative.

Such errors dont show up in Phase 1 trials, Adler and Schatz said, because theyre focused on evaluating safety. And these early trials dont have many patients, there arent enough to comfortably determine the therapy is really effective.

By the last stage of the trial, these sources of error have often been identified and trial standards have tightened up. And thats when the faulty assumptions made early appear as the trial ends in failure.

Despite those forbidding hurdles, Adler said research should continue.

This disease is killing a lot of people. Theres not going to be enough hearts to go around for transplant. Theres six million Americans with heart failure, and theres 2,000 heart transplants a year. So coming up with novel regenerative cell-based therapy is something were still excited about.

bradley.fikes@sduniontribune.com

(619) 293-1020

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Study: heart failure stem cell therapy safe, shows early signs of effectiveness - The San Diego Union-Tribune

Stem cells offer hope for autism – CNN

It wasn't always so. Just a couple years ago, Ryleigh, 11, was scared of her sister when she'd throw tantrums and screaming fits.

"She would've fought and kicked," Ryleigh says, noting that it wouldn't have been possible to sit like this next to Gracie.

Gracie, 7, interrupts: "I don't even remember it."

"We do," says her mother, Gina Gregory.

Gracie has autism, a condition that affected nearly every aspect of her family's life after she was diagnosed at 2. But a new study is offering hope for the Gregorys and families like them.

The results were impressive: More than two-thirds of the children showed reported improvements. A larger second trial is underway, one its researchers hope will lead to long-term treatment for children with autism.

But for the Gregorys, the change in their daughter has been monumental.

Gone are the days of Gracie throwing fits in long lines at Disney World or during dinner at restaurants. When a tantrum intruded on family outings, her mom and dad wished they had T-shirts that said "My kid has autism" to ward off judgmental stares.

During autism therapy sessions, Gracie would kick, scream, spit and hit at her occupational therapist. "It was horrible to try to get her to sit there," her mother says.

Even just brushing her teeth or combing her hair could set her off.

Gracie, then 5, was on the mild to moderate autism scale, but her parents say the disorder consumed about 75% of their daily routine. After her participation in the study, that figure has been reduced to a mere 10%.

On a scale of 1 to 10, they rate her improvement around an 8 or 9; it's been that dramatic. She's even begun attending a "regular" school and thriving there, something her parents never thought possible. She'd been in various specialized school programs, and nothing was the proper fit.

Are Gracie's changes a result of the cord blood transfusion stimulating her brain? Or did her brain just mature as she got older? Could it be that her parents were subconsciously determined to magnify her improvements, given all their family had been through?

Those are questions the Gregorys still ask. But they do know that their daughter's transformation appeared to begin about six months after her transfusion in January 2015 and has continued ever since.

Her father's favorite adjustment is her newfound affection. Instead of shunning hugs, she now welcomes an embrace.

"We will say we don't think it's cured her. You still see some of the small idiosyncrasies that she does have," says her father, Wade Gregory. "But again, I think it's supercharged her learning curve. It's pushed her to do things she normally wouldn't do."

Her mother adds, "She got better, and we're just thankful for that -- whether it be the stem cells or not. We're just thankful for what changes have happened."

Each unit is designated by labels with specially designed adhesive to withstand extremely cold temperatures for decades. There are 14 cord blood freezers in all.

It is the cord blood in those freezers -- stored or donated by parents in case a serious illness develops -- that's at the cutting edge of this research.

About 30% never learn to speak, and many children even with early behavioral interventions still struggle to adapt. There also are no FDA-approved medications that improve the core symptoms of autism.

"I was very interested in collaborating with people here at Duke who could offer medical approaches that could enhance neuroplasticity, or the brain's ability to respond to treatment," Dawson says.

"We've been able to show that with some of these diseases, a cord transplant rescues them from death and also improves their neurologic outcome," she says.

She began wondering: Could cord blood help other children?

About a decade ago, her laboratory began clinical tests of children with cerebral palsy whose parents had banked their cord blood. Again, they saw positive results. And in some of those children who had autistic tendencies, they saw autistic symptoms improve. Another spark went off: What if they tested cord blood specifically for autism?

The safety trial began a little over a year and a half ago. Not only did it find cord blood to be safe, but 70% of the 25 children, age 2 to 6, had behavioral improvements as described by their parents and tracked by the Duke researchers. The research is largely funded by a $40 million donation from the Marcus Foundation, a nonprofit created by Home Depot co-founder Bernie Marcus.

The children traveled to Duke three times over the course of a year. They underwent a series of evaluations such as autism assessments, MRIs and EEGs to track their brain activity. On the first trip, the children received the cord blood infusion along with the intense evaluations. Each child received 1 billion to 2 billion cells, given through an IV in their arms or legs. At six months and then a year later, the children returned for more tests and observations.

"Some children, who were not speaking very much, had big increases in their vocabulary and their functional speech," Kurtzberg says. "Many children were able to attend to play and have meaningful communication in a way that they weren't before. Some children had less repetitive behaviors than they did when they came onto the study."

Adds Dawson, "The study was very encouraging. We did see positive results. However, it did not have a comparison group, which is very important in establishing whether a treatment is actually effective."

Both researchers can't stress that enough: that although they're cautiously optimistic about the results, they want the science to play out. They are now in the midst of the definitive trial on whether cord blood can treat autism -- a double-blind, placebo-controlled trial involving 165 autistic children, ranging in age from 2 to 8. The FDA has oversight of the study.

During the phase II study, the children on their first visit receive a cord blood infusion -- either their own or from a donor -- or they get a placebo. They also undergo a battery of assessment tests and brain monitoring.

On their second visit six months later, the children receive a second infusion with whatever preparation they did not receive the first time and undergo more evaluations. The order of the infusions is not known. Researchers will monitor them for the next year for any sign of behavioral improvements.

It's known as a crossover trial, in which each subject gets the treatment and the placebo but in a different order. Researchers say it would have been nearly impossible to find participants if parents knew that their children might not receive an infusion.

How groundbreaking would it be if the trial shows similar results to the safety study?

"If we can show that receiving an infusion of cord blood is more effective for improving social behavior than the placebo," Dawson says, "then this will be game-changing."

Kurtzberg adds, "We'll be extraordinarily encouraged if the second trial shows that the cells benefit children when the placebo does not. We will consider that a breakthrough."

Both researchers were shaped early in life by the struggles families face raising autistic children. As a teen, Dawson babysat twins with autism who lived across the street. "It was just an inspiration to devote my career to improving the lives of people with autism," she says.

Kurtzberg was similarly affected. When she was a junior in college, she would visit a girl with severe autism and play with her as a means of behavioral intervention. "The family still writes to me," she says.

It is for this reason -- their longtime devotion to families raising children with autism -- that both issue a heap of caution. Although they're excited about the results of the first study, Kurtzberg says, "we don't want to mislead people and claim it's working before we have definitive proof."

Adds Dawson, "It's important for parents who might hear about cord blood as a potential treatment for autism to know that we are working very hard to know the answer to that question. We aren't there yet."

Kurtzberg has a hypothesis about what may be happening: that certain immune cells within the cord blood are crossing the blood-brain barrier and altering brain connectivity while also suppressing inflammation, which may exist with autism.

"I feel more confident now because of our (cerebral palsy) study, which preceded this study and does show benefits," Kurtzberg says.

"One has to be very careful when interpreting results that haven't come from properly controlled, double-blind studies," he said. "All I can say is that it would be wonderful if this treatment was effective, but one has to be very cautious before reaching any conclusions."

Even without a placebo effect, he says, many factors could have resulted in an improved outcome in the first study: The growing children could have acquired skills simply through maturation, possibly enhanced by occupational therapy, and their parents may have clung to positive gains, creating a biased outcome.

Kriegstein of UCSF also wonders whether cord blood is really stimulating cells in the brain and creating new connections. "There are so many unanswered questions about what might be going on here, it becomes very difficult to evaluate the proposed mechanism," he said.

"The question remains: How do these cells injected intravenously wind up in the brain, how do they target the appropriate brain regions, and what are they doing that could improve brain function?"

An 8-year-old boy with autism sits at a table in a room within Duke's Center for Autism and Brain Development. Clinical research specialist Michelle Green watches from behind a two-way mirror. Two cameras in the room feed computer monitors, allowing her to further analyze his behavior.

Dr. Lauren Franz, a clinician, works with the boy in the room.

"What kind of things make you feel threatened or anxious?" she asks.

"Like when I'm done with a test," the boy says.

"How does it feel when you're frightened or anxious? How does that feel?"

"Like pretty weird," he says.

The boy is participating in the second trial, and he's returned for his six-month assessment and second infusion. Researchers don't know which infusion he received first: the cord blood or the placebo.

But they track, record and monitor the slightest of details. Although it might seem like an innocuous conversation, researchers will compare the results with those of his first visit and any follow-ups. Was he able to sit still at the table before? Could he articulate his thoughts? Did he talk before the study? Has he improved?

At the Gregorys' home in Florida, Gracie's parents remember when she went through those same tests. The best investment they ever made, they say, was the $2,000 spent on banking her cord blood. At the time, it was just a precaution; her autism diagnosis didn't come until three months after her second birthday.

They know the desperation of families raising a child with autism -- of longing for their daughter to have a shot of normalcy in life. "You can't quantify it. You can't measure it. You want to see your child succeed," her father says.

Mom and Dad recently watched old home videos, of Gracie singing inaudibly, of her covering her ears when "Happy Birthday" was sung for her third birthday, of showing no emotion on Christmas when she was 2. "I forgot how bad it was," her mother says.

They hope the current study leads to similar successes -- and results in breakthrough treatment for autistic children everywhere.

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Stem cells offer hope for autism - CNN