After Decline Of Steel And Coal, Ohio Fears Health Care Jobs Are Next – NPR

Coal and steel jobs were once plentiful in Steubenville, Ohio. Today, the local hospital is the top employer in the county. Courtesy of Rana Xavier hide caption

Coal and steel jobs were once plentiful in Steubenville, Ohio. Today, the local hospital is the top employer in the county.

When people talk about jobs in Ohio, they often talk about the ones that got away.

"Ten years ago, we had steel. Ten years ago, we had coal. Ten years ago, we had plentiful jobs," says Mike McGlumphy, who runs the job center in Steubenville, Ohio, the Jefferson County seat.

Today, the city on the Ohio River is a shell of its former self. And health care has overtaken manufacturing as the county's main economic driver.

1 in 4 private sector jobs in the county are now in health care. The region's biggest employer by far is the local hospital. Trinity Health System provides about 1,500 full-time jobs and close to 500 part-time jobs, more than Jefferson County's top 10 manufacturing companies combined.

Still, unemployment in Jefferson County stands at 7 percent, 2 percent higher than the state overall. And health care leaders worry that the Republican proposals to repeal and replace the Affordable Care Act could take many health care jobs away.

Specifically, they're concerned about the rollback of Medicaid that is central to both the House and Senate bills. Ohio was among the states that expanded Medicaid under the ACA, adding 700,000 additional low-income or disabled people to the rolls.

The Congressional Budget Office estimates that the Senate bill, the Better Care Reconciliation Act, would cut Medicaid spending by $772 billion over the next 10 years, whereas the House bill, the American Health Care Act, would cut the program by $880 million over the same period.

The local job center in downtown Steubenville, where people can get support applying to jobs. Jessica Cheung/NPR hide caption

The local job center in downtown Steubenville, where people can get support applying to jobs.

At Trinity Health, 1 in 5 patients are on Medicaid, slightly lower than the state average. Joe Tasse, the hospital's acting CEO, warns that cuts to Medicaid could imperil jobs as well as the hospital's bottom line.

"It would be pretty devastating," he says. "If Trinity Hospital were to fail, this region economically would fail."

Tasse says under the AHCA, Trinity could stand to lose $60 million over 10 years. He says that's the equivalent of a thousand or more hospital jobs.

His fears are backed up by the liberal-leaning Economic Policy Institute, which projects that more than 81,000 jobs in Ohio could be lost within five years under the AHCA, resulting in a 0.7 percent drop in the state's overall employment.

A big challenge, Tasse says, is that departments such as emergency care and obstetrics, which have high rates of Medicaid patients, are also among the most costly to operate. Given the 24/7 nature of the care they provide, they can't cut back on staffing on days when demand is slack.

Nurses at the telemetry unit of Trinity Hospital respond to patient calls and monitor patient vital signs. Jessica Cheung/NPR hide caption

Nurses at the telemetry unit of Trinity Hospital respond to patient calls and monitor patient vital signs.

"An OB department is really an emergency department for women and obstetrics," said Tasse, pointing out that most births are not scheduled. "If you want to have that service and provide it for your community, you have to incur that cost. There's really not a way around it. Unless you want to tell the women, 'Hey, we're closing our service,' which many hospitals have had to do. 'Here's your bus ticket or here's the car ride that you have to take to deliver.'"

Trinity's obstetrics and emergency care departments are now also dealing daily with the opioid crisis. At Trinity, 1 in 5 babies are born prenatally exposed to opioids, adding complications and cost. In the emergency room, nurses are seeing so many overdose cases that they are set up to meet patients in their cars at the entrance, armed with the antidote drug naloxone.

Under federal law, hospitals are required to treat anyone seeking emergency care. So if Medicaid were cut back, Tasse says they wouldn't turn patients away at the door. They would scale back in other ways.

"Where we've tried to move patients to preventive [care], identifying health problems earlier that would all go away," he says. He'd expect more patients showing up in the emergency department, "sicker [and] more expensive."

Read more:

After Decline Of Steel And Coal, Ohio Fears Health Care Jobs Are Next - NPR

McConnell allies confident in healthcare win – The Hill

Republicans close to Senate Majority Leader Mitch McConnellMitch McConnellOvernight Finance: CBO: 22M more uninsured with Senate ObamaCare bill | Trump gets green light for partial travel ban | GOP: ObamaCare taxes must go Senate Dems plan floor protest ahead of ObamaCare repeal vote Senate Dems set principles for potential budget negotiation MORE (R-Ky.) are confident he can save the Senates teetering healthcare reform bill, the Better Care Reconciliation Act, over the next five days though it's shaping up to be a daunting task.

Some Republican senators are skeptical that McConnell can stick to his ambitious plan of passing a major overhaul of the nations healthcare system before Congress takes off for the July 4 recess.

But the majority leader and his closest allies believe he can wear down rebels in his conference after 20 hours of floor debate and an unlimited amendment process, which will give colleagues a chance to hammer out a compromise.

A GOP aide familiar with internal discussions said Senate Republicans are going full steam ahead in anticipation of a vote later in the week.

I have no indication that anything is off in terms of the floor. Were preparing to go in every possible way, the aide said Sunday.

Some GOP lawmakers have their doubts, however.

Sen. Susan CollinsSusan CollinsIs Senate ObamaCare repeal bill too mean? Funeral for the filibuster: GOP will likely lay Senate tool to rest This week: Senate races toward ObamaCare repeal vote MORE (R-Maine), one of the chambers leading moderates, said the bill needs to be reworked.

Its hard for me to see the bill passing this week, she said Sunday on ABCs This Week.

Five Republican senators four conservatives and moderate Dean HellerDean HellerIs Senate ObamaCare repeal bill too mean? Cornyn: GOP won't delay ObamaCare repeal vote This week: Senate races toward ObamaCare repeal vote MORE (Nev.), who is facing a tough reelection race in 2018 have announced their opposition, and several other centrists are voicing serious concerns.

Republicans control 52 seats and can afford only two defections to still pass the bill, assuming no Democrats vote for the measure. Vice President Pence may need to be called in to break a 50-50 tie.

But the math is complicated; making changes that conservatives demand would cause more moderates to come out against the bill, while appeasing centrists by watering down cuts to Medicaid risks a rebellion from the GOPs right flank.

Even so, McConnells inner circle believes he can put together 50 votes in the next week to pass the legislation because of his most powerful argument: failure is not an option.

Senate Republican Policy Committee Chairman John BarrassoJohn BarrassoA bipartisan consensus against 'big pharma' is growing in Congress McConnell allies confident in healthcare win Dem senator: GOP's healthcare approach will 'devastate Medicaid' MORE (Wyo.), a member of McConnells leadership team,on Sundaysaid that leaders have enough flexibility within the legislation to address the concerns of colleagues who last week said they cant support it.

I believe we do. I believe well get it passed, he said on "Fox NewsSunday."

Thats the only way we can fundamentally change away from ObamaCare, get rid of all the hated mandates and the taxes and put Medicaid on a sustainable course long term.

Josh Holmes, McConnells former chief of staff, says the leader will find a way to balance the concerns of GOP critics on both sides of the ideological spectrum.

I think theyre having conversations over the weekend that hopefully will send that in the right direction, he said of the legislation.

While conservatives such as Sens. Ted CruzTed CruzTrump phones Senate holdouts on GOP healthcare bill A bipartisan consensus against 'big pharma' is growing in Congress Cornyn: GOP won't delay ObamaCare repeal vote MORE (R-Texas) and Mike LeeMike LeeTrump phones Senate holdouts on GOP healthcare bill A bipartisan consensus against 'big pharma' is growing in Congress Cornyn: GOP won't delay ObamaCare repeal vote MORE (R-Utah) have criticized the bill for leaving some of ObamaCare's regulatory reforms intact and Sen. Ron JohnsonRon JohnsonTrump phones Senate holdouts on GOP healthcare bill The Hill's 12:30 Report Cornyn: GOP won't delay ObamaCare repeal vote MORE (R-Wis.) says he needs more time to decide, they have left themselves room to vote yes, Holmes said.

They've had every every opportunity to draw a hard line and and say no. And they're leaving themselves some some wiggle room, he said.

McConnell can argue to conservatives that voters expect action after Republican candidates spent the past seven years campaigning against ObamaCare. The alternative to passing the Senate bill is to live with the current law.

McConnell can tell nervous moderates that the Medicaid expansion under ObamaCare is not sustainable and that reforming the program is not necessarily a political liability.

Its important to point out that this bill has yet to undergo any debate, amendments, negotiated changes. The White House has yet to engage; were at the starting line here, said Scott Jennings, a former senior political adviser to McConnell. Were a long way to say that people are definitely going to vote against it.

Jennings said McConnell, as a representative of a state that expanded Medicaid enrollment, is well positioned to persuade moderates to accept the bill.

There is absolutely no electoral empirical evidence whatsoever that favoring repeal of ObamaCare or favoring Medicaid reform or even repeal of the expansion has ever cost a Republican an election, he said. We just won the White House and the entire Congress and just about the entire party ran on repealing ObamaCare.

Senate GOP leaders expect an analysis from the Congressional Budget Office on Monday. That report will give them a better idea of how many Republican votes are up in the air.

A vote on a motion to proceed to the bill, which requires only a simple majority to pass under the budget reconciliation process, could happen as soon asTuesday.

Also this week, Senate Republican and Democratic aides will present their competing arguments to the Senate parliamentarian for why key sections of the bill either comply with or run afoul of the chambers budget reconciliation rules, a process known as the Byrd bath.

One Senate aide familiar with the process says the Byrd bath named after late Sen. Robert Byrd (D-W.Va.), who established the six-part test for determining whether legislation is eligible to pass with a simple majority takes about a day.

McConnell has his work cut out for him.

He must persuade at least three of five GOP colleagues who oppose the Senates healthcare bill to flip their positions over the next five days.

One of them, Sen. Rand PaulRand PaulTrump phones Senate holdouts on GOP healthcare bill Cornyn: GOP won't delay ObamaCare repeal vote GOP senator: Leadership trying to 'jam' through healthcare bill MORE (R-Ky.), his home state colleague, is viewed as irretrievably gone. He has panned the core of the bill a system of tax credits to help low-income people buy health insurance as "ObamaCare Lite."

Another, Cruz, has had a notoriously tense past relationship with McConnell and at one point called him a liar on the Senate floor.

A third, Heller, is the Senates most vulnerable incumbent andon Fridayslammed the bill in such harsh terms that it will be very tough for him to change his mind without a major rewrite of the legislation, lest he be accused of a flip-flop.

John Weaver, a Republican strategist who served as a chief presidential campaign strategist to Ohio Gov. John Kasich (R) who opposes the Senate bill predicts that McConnell will come up with some concessions for Cruz, Lee and Johnson to spur them to vote yes.

He said they will be accommodated with some fig leafs, not dissimilar to what happened in the House with some of the Freedom Caucus members.

He said yes votes could be tougher to secure from moderates, but McConnell may be able to corral them by adding more money to the bill. Right now it includes only an extra $2 billion to fight opioid addiction, far less than the $45 billion that Sen. Rob PortmanRob PortmanMcConnell allies confident in healthcare win GOPs message on ObamaCare is us versus them Sanders: GOP healthcare bill is a 'moral outrage' MORE (R-Ohio), a potential swing vote, wanted.

I do worry that McConnell will agree to add to x-billions of dollars and it will be enough for a couple of these moderates to say, 'I held out and they added some more cash and now I can support the bill, Weaver said.

This report was updated at 8:02 a.m.

See more here:

McConnell allies confident in healthcare win - The Hill

Koch network donors eye Trump and Congress warily on health care, taxes – Politico

Individual donors in the network have donated significant sums to President Donald Trump and super PACs backing him. | Getty

A combination of hope and concern infused the summer seminar meeting of the Koch brothers' network of conservative groups.

By Kevin Robillard

06/26/2017 01:13 PM EDT

COLORADO SPRINGS, Colo. Conservative donors see a major opportunity this year to achieve years-old Republican goals of reforming the tax code and passing a new health care law. But they are also consumed with worry that the GOP will somehow blow the chance it has been waiting for whether because of an unfocused President Donald Trump or fretful congressional Republicans.

That combination of hope and concern infused the summer seminar meeting of the Koch brothers' network of conservative groups. Before a gathering of over 400 donors at the luxury Broadmoor Resort, Koch officials spoke of an enticing but narrow window to pass major tax and health care legislation, even though Republicans control the presidency and both chambers of Congress.

Story Continued Below

We have a window of about 12 months until the 2018 election grinds policy to a halt, said Tim Phillips, the president of Americans for Prosperity, the networks grassroots organizing group.

After waiting eight years for another Republican president, some Koch network donors now worry that the current one could end up being an obstacle.

Trump doesnt have a core philosophy that we have, said Colorado energy executive Chris Wright. Wright, who said he voted for Libertarian presidential nominee Gary Johnson in 2016, added: We dont have a clear, consistent direction from the top.

I think we have 10 months and a rare opportunity to shrink the influence of the government on the economy, Wright said. The one we have now who can sell the public is Paul Ryan, but he doesnt have the bully pulpit. The person with bully pulpit is not a great seller of ideas and progress.

Sign up for POLITICO Playbook and get the latest news, every morning in your inbox.

By signing up you agree to receive email newsletters or alerts from POLITICO. You can unsubscribe at any time.

The Koch network, organized by brothers Charles and David Koch, is a collection of conservative donors who have donated billions over the decades to everything from Republican politicians to school choice efforts to university think tanks in an effort to move the country in their ideological direction. The groups allies and former staffers hold key positions throughout the Trump administration, and the network announced plans earlier this weekend to spend nearly $400 million on politics and policy over the next two years.

The Koch network declined to directly back Trump's candidacy in the election last year. Top network officials have been pleased with his administrations court appointments and work on tax reform, and were ecstatic about legislation he signed last week reforming the Department of Veterans Affairs. But they were sharply critical of Attorney General Jeff Sessions stance on criminal justice reform and the GOP efforts to repeal Obamacare, arguing the Senate bill doesnt do enough to lower premiums and totally repeal the law. (The network isnt officially opposing the Senate proposal, but is working to make it more conservative.)

But individual donors in the network have donated significant sums to Trump and super PACs backing him, including Doug Deason, a Texas-based donor who is the son of IT billionaire Darwin Deason.

Deason was more bullish on Trump, particularly praising his pick of Supreme Court Justice Neil Gorsuch. Anything other than Gorsuch is gravy, Deason said. Even if he just tweeted and pissed people off now, Id be happy.

But he also said he and a group of about ten other Dallas-area donors planned to withhold checks from out-of-state Senate and House GOP incumbents until Trumps agenda, including Obamacare repeal and tax reform, made it through.

Deason said Senate Majority Leader Mitch McConnell needed to grow a pair. We want to send a message about how important this is, he said.

At the same time, Deason said he had recently met with leaders from America First Policies, a nonprofit backing Trumps agenda that launched attacks on Nevada Sen. Dean Heller for opposing the Senate health care bill, arguing it cut Medicaid too harshly and did too little to lower premiums.

Deason wasnt the only donor who worried about whether congressional Republicans will ultimately pass major legislation.

Bob Fettig, a Wisconsin metal fabrication company owner, was optimistic about the chances for tax reform. It looks like theyre serious, and theyre actually going to do something to simplify it, he said.

But Fettig added: The big question is, when it gets down to vote time, are they going to introduce all kinds of amendments to undo the simplicity of it?

A lot of people are frustrated with our government in general because politicians dont do what they say theyre going to do, Fettig continued. Im confident that Trump will continue to push forward. Politicians are continuing to be politicians.

Despite the apprehension, none indicated they were ready to shut off the money faucet into GOP campaign wallets. Even Deason, who said he had organized Texas donors to deny Republicans campaign cash until Trumps agenda is passed, admitted he might not be able to follow through.

When a reporter asked if he would donate to Republican senators next summer when McConnell called even if the presidents agenda flopped, he responded with a shrug: Yeah.

Missing out on the latest scoops? Sign up for POLITICO Playbook and get the latest news, every morning in your inbox.

See original here:

Koch network donors eye Trump and Congress warily on health care, taxes - Politico

Amid health care debate, mother’s photo of Boston Children’s Hospital bill goes viral – Boston.com

As Senate Republicans work to pass a health care bill, Alison Chandra thought it would be fitting to shed light on the financial realities of her sons care at Boston Childrens Hospital.

According to Chandra, her son Ethans most recent open heart surgery forheterotaxy syndrome a rare genetic disorder in which organs form incorrectly or in the wrong place would cost their family $231,115 without health insurance.

From more than $47,00 for coronary care to nearly $43,000 for supplies and implants, the striking figures quickly pile up. Yet with insurance, the New Jersey family was left owing just $500.

In a series of tweets, Chandra said her son already had four heart surgeries and will likely require more, in addition to regular appointments and prescription medications.

According to Chandra, Ethans prenatal care and first two surgeries were paid for through Medicaid, until they were able to switch onto her husbands employer-sponsored insurance.

The draft legislation introduced by Senate Republicans last week would cap federal Medicaid reimbursements, effectively cutting the program by billions, while repealing the Affordable Care Acts 3.8 percent capital gains tax, among other taxes targeting high-earning individuals.

[Ethans] life is infinitely precious. Thats why we fight so hard, Chandra wrote Friday. And now this bill wants to take all that and throw it away for the sake of tax cuts for people who dont even need them.

The nonpartisan Congressional Budget Office estimated Monday that the Senate bill would increase the number of people who are uninsured by 22 million by 2026 compared to the number under the current law.

The bill would also allow states to waive the Affordable Care Acts standards for insurance requirements, including a slate of essential health benefits, such as inpatient and outpatient hospital care and prescription drug coverage. In an interview with CNN, Chandra said she is scared of how Ethans life would be affected if the bill is signed into law.

My fear is that this bill comes into play and suddenly essential health benefits are no longer covered, like hospitalization, prescription medications, she told the cable news outlet. He will rely on prescription medications for the rest of his life. He is functionally asplenic and will need to take prophylactic antibiotics the rest of his life to prevent and protect against sepsis, a huge risk of death for our kids in the heterotaxy community.

As of Monday afternoon, the photo of Ethans bill had been retweeted more than 53,000 times. Chandra said many had reached out to ask about financially supporting his treatment.

Because we have insurance, we dont need financial help, she wrote. Just fight to help us keep that coverage.

Boston.com on the go! Download our free app.

Read more:

Amid health care debate, mother's photo of Boston Children's Hospital bill goes viral - Boston.com

You Can Get Your Whole Genome Sequenced. But Should You? – WIRED

F(z 4#H/%umkoK$IH @`Qk8/w/L7*q@h7x}Jg?5y"}Du"k}&2xt1z .Z^M y`y4TEYI=Hu]~8<(8y[G:3q[(i 3|C-l#a9q'^eR$ME.(gUuSQe"mtS-6)JJ%i%Jht:iz-u|Qj=_ZZehc!&rMJMbe8jx[6u($j"1/BMd.gr*_diy4]h*-ab>ZFn5q-qs0FFj?~^w?E~-Z$ ;w,VVuQGzT:B 83j)D/kFwJkqv0^d|bf8[bSy|,*qI'w[]; **c&G<"JK|(L!bY}U<>Y| "^AT:K.*6/0@C,YM2 h,w_=l @@@<:__ADgbvU }=~?g#pLU (I'g,%:?1P"p"H_&8PaT4(bGQp="4@b< CP ~}*=1/X*4x~ 66A4~sgl2 rf.._931qZ._G#,qK%ghybf4OY}w}"K/gb kj=Y:*e~_6-c}Egb(qNg+G~LY c%yrUz#X-' jQZg*bMrL%}`b3>,3@u]oaaO7t{OQMI:I;-s=!Ngm76l~[DnBFQ{*"YkR:h-xZHEQGMKeY~[i"&2f"'@9sxn o{ }?V:(kolCnt<7yL,Zk~H,Zw h|R6n7Pu}zpp3"o;VN/||L#=5g(bjC7Y($P)4#2O!hwjZdmO! ^{8d}hj1}h{tavWsZQG&g"I" T,E,`bv@^!w vNx|g#ldoO+X?<go|U_ 2dUg00t8RcfUG3*evYB@W]h&8R-}vA(/EEP*B=@D6iS~OKX]RR;,>"pmAmDr. +}BQsr+ rmj=:vciu|*;;iztbwi+WrjytNGFNL*3^p{=`s77[;cc~kiS(7BAW8:9!Nk~y~+,ai*h)>b%TEo2w!v3lnoJA,NM{?1fi~{(a`m;^.f_x Kf<l%6UT-95eZ%AGu1r^AelXNLIoM~ZFMRV7U^ 6?S/>} yXw#}a4US-*Mv:y0 IK&M8 #n( (r:M*%~ dVf_8itrv%5tKs}hmF}pOp {W%9Vm4&elFSz!hU5!#{@F+`1/xr"YrwzIhS173I7~K?dC3rPG:)cfjql?B@q#/6o3|>>z61olQOt?g0B6}P!GU &P(3wi(Bt$,!w8$N)Td(At0WqEbAMd7k|WS{=jeZodT'|Ix&;z>>?& _(EagnI '2|^4omhj1_ )QQ]=/A~Bo+B*PQ/NH$_&_ PAr=^`@4[i2i[&q-84<`xex8{gn@>`> >`M|mex8{g6qxix83|H>d(vlcqxex8{gM'Y|Hz>Dn@$B6|O}2{h8$>d=MC?=xGTx ]2I;~xLMxfx)ag{asO=l! ]G:DH=Hz9DsxH`{|!d4X'Z>; xm=>iO4|c'[>-clD}3{qs(ty|ismVclDc+1bH9 )Dc+14111D1I:I|yO;>!R>{bbDY>$Z;!Bhl

UL8yFJ 'pz*iC&"&P`G&VeSSZ?d* p4`3ASZjdpls) &Ll!5vAz^T(@to9TTP/~AT8dCjC@d2M8TAtIfH= lBY2!",w;ugBYdy^u5*4jBDrw[5(RDXDZ3+-^XSQ>6q.]`AplDw>~i D:zwIAR,M]|4@wvU!}uZijumqBGQt+{G9KK"m/C8Ey.2mQbR{F|wZeY-v!l.72k{:Ln',=sOXS,{J1jj="p1[<_bYhx?=^U]k. s}*j.q8jAB8:4dnKbp"Y^ooM~Z!H%k^]v~w; 9`,{0$T[x$D%50X:'E<(a`*k~PQW[MGX Z.T-Y4"2$.N"fnG(/C'~3;AaRH2eMs gfeI/":x" I^ N{)pWxa8Z-E+N=g"Y_>+0"HGEX(e*t'`KY}|`/@1Z,AR2TDH}qMsE %$5,jaWpbCS]nN |0 ohyCf] N 4s=RG7Ghb ZX:XSX_ tt/{hfb0C}HQY_v%|z<.~,3m-6%O;>!*Ioy.osSC|{!{G;D((9OOt|''z9>O3|hl-g8'77|%xfD[/[ xRxBE|2< xXu ):OX1 #[Od+ $xysy@M'yd+!CNc'} $[!CK!Oh)$Y y,!Oz@z@hd>ch<^HMaG%#4]LP1 :vdBaG[#T9*bDW;2!@S~ $efn&DMbgLH_`2&1yZ&UlRR(5`G *Xd0vdB*y"*lB=&"&MhSA#u&Qj

<9&TR1* 0mjfSkLeLjy!j#tAj31e^L:/ &!^yV1tdB(HC:LqB't$sL2j9L&Cp2(% E0YD0jPC5&ZddR?LLxvdAZdpeJt.SFKH ; @L1"#rbDM4J#T.`zd.IRn][' *0&Sa.jCKR.SZ deRKDL5L$bU2U8D.9&SCSC$LLLLzf1yv)zwL-&a2U8DA3}jAAha28D.y.:8D.R8|( #Tg2H=L&TP'rT )RBdX; @=/`*pr dZdUp[T dBU2Y!5!dJ`L2& b$3LG6!,X; @= lB!!(d:3 YQxLLj -RLJV&TV2I 7d*)eQKJYL%,jE'!vAXL,j1emBMaG&hf9vdB?y S=#Zbgph; @ #T.y3.I,JTP " Cp Du"4X7=fI:EgQk>"y|asuFEeY4=up10L82R-LQiZAOT/HYu5VG(}Mv;D]7roFgUW8|E?*NE.>fe-xD)Kl36!~=NIr+mRZZS5 i^L[R{P{$DT fYLC%A&SE3jeW?-8gm# :~Z"mP?J[ZRuQV;g RFdk+l +03?-a55@QZ1ZCJ%Lf<$(Ob26/pf!@ih3m1[WQ^uN56+VItVkMq?P{TSRg$3-beq-tf=/aa['0mLbDs;qIB[EUEZf}w +A[TXGxt2-,7rRsXjZs 6{.BNYC+kl&([%J sPS [HBmwXab|_j .JJ@eQ (R,x0M$F79(9S3klC?p,YBXgV!L(>{I PDh+C,BHe@O,i~z$' XQ:z6l$F2l=]wKmY*BJx$mPK+ j=_jf^-FlX,y,~Bv(l%(``J<|u F E ,CI-+Te<*WS#:r)rz%UKI(/an&s5YNB<``|%xUH[,FvI|*z$?V?"Ukj&H'W`ta|rlSY @O+%+n(G4[1kX,]I8FI J0j mB%dfGpi@/a/* 3?%IQJZhTi`j)h<5>./XXHT2ERf)<66Q@_hQFl/7l!Sko4<"Ic 6~-a#aH$m48rU-EZG<$U"de#Hn-< G,P]-RZ3Zz-icV#m,V@/JJ<(V?Ii>Ac5MZ5)WR5lTRVJuR=r{LqL7>i&()h`@I RH^Lh6N]q- Ke2E@/]YeGIBEDTR)2my$ [1_L@J@T ;g=P5t`UFI.p] `q]~(dm$t0jTu+q 4tEy^Ml_tmhJHK@IR!_y%J;AQ!793+oQ P2`6+b0(VSuzWT[v*G]T}r22~R*tPz2nw6 /zo )Ct!rdwm!a["L*}8.m`d!mUeqapZkJy9*}!3BN/<}> C!@F2/K>--~au&_E_rOnJ_obYJzRMHkS! `I[-]|c4Uw0:-M~-r"bQmO^g`c(&:,EG7A"ji &*}c5W3'-f5w>6u('9N/rsfCIsf vq?_kH^:!|C6>%3=GyQw]~}}T)rw4?+e&EVn`DrXphgMs)k[hmDAu.}S/JO&9=ycN~{$gmbrBzc !={#9'xvc@w6/o_tc r3IU-II)c i/e`4L~[eI@q5L`uJY^ng2O?;'iXuS#/%2]}[D[aWfV:uc^L&zGCGroupTd.rT_NdDWNXTJPh'!((j&kok FwQ^+g]F|ai^ D;P>Mr"Cr2M-1ty)B"GY Nq/.[Y]G%orH${I@A$LXnB+z~Dz+zJ_[L}Lb[zc2.PXud]2]*M"T60=S;!opF&M! JdMn-_ oC6-+Z4.$~Gmh;];2vg,N+[cwU_~qE{yBHX#{J;PIj~wvfO@40k`Ru_,UJ}6^u*`8.tk a{[{o~3RwC]'BWu^eAlr[eH+1gP7/sn7[{Q^GRt9)ZE G]0I[-< bkb9e=M(|]S}@^nwbWgxf."|OVsBWi z1#}Ld*/=C:2U#)&CxLfv}w r{1lpaa1[,_1q*TZ:<}~yYdU3pg )2tkLlS"{+"rQ]=x|7s9e&?s q+JS/v")l{n~0PP3Q&C=gVb%^?NGyE&,3|'b?L@b&v$bK(%y) L|N{7nN|;=qz IF:wCyX0E>[;(6'o6|@82Yx+?`L/:F|U3a2dM}*qYd[Uz.j| |_0oI }*P Zg9$g{rt+M+2^I1ybC=ia*^)Vb>,QA^D.zhTMWMvG;qUN9^b0{|]s|g^q_d7WF+AE%b1+$ UH>A!R!_h#wFs>W!s-?Ax=D_Ixw,+Gx&DgD' xwSrhnK+cW1:|U{`{yJuBy0N<{l~XxA;%F9^mQ10vf!A3F6foyd){MUB.">i]hb2uH2_#lS.I6tVXO*XZ&Kf8YtXE =Kz!|88=`|x;em"XR>G?iI=Cs,l}/{!$/I] EIdX.L.Z?P4pZuzb^0uOXseR|^jv#H>Y(Q^K/q__>*Itu]6uY+teNt-[$]G=u|0@};pwpx1A,/4,g$@9y&5qu/=R9h%Rj.{4o&w}U=B $)ZU jQujF zn[s+-AaES*WEEZOE.:k=jWGIjK'&'J 0GpLZovRv Yf5M6&&mp=YTG{(v{g]*/Dl[)L^Km#7GbiuX?+#V??=ojy"ZrVQ*]UoW{ns!_aY5C5<*#6UE9d.5~lvOw= c>IE'UZ;bm(XAfzz2Unjyq vvWgJQa9eR_fTwj-6]K!,]+}bnFZC:GXO6Az7._N-Ai87yl.^]i^wXGVwzR=WTYhjvwj't;QS U]fg^p>[/>YRgxWY=iqZd .kSoU<`(|#VN||w{c^8h(f=kVG$ kF1H`2Bu:'>e g#0eJl{XGHbbcx'd4}Mv' t|M]u|w6_d|meaoyx|U^r34"D5{k2-XFK,z.7>i|62*pAe-2Dz/oJiu%FV4A~7 %AO&=I^Bq`*7A"eU]!t8D%G=Lz=4s%zV9 -9XeX,jw`,w 0[^Q.:g%xg?^{(&DZh2GHWv>k?v+sG9MeUA>d6v#o?WOd9iZ;R^9&@2Gk-/jm."Y"9tAcx>QVZQDK`@BV;2"b(Pnm>;nwQ%d()z(7JkYA =JHjCk 3~ac7C,UzY+]:]aXnnm7vHv<9s}FXq&!?{bFqks(2S//Z$C jjS?<(UGfE&cYi%jV,Ab*.:-?-a^eRv?_IEy]t1x:Hc qV,I &0`|P<| Pb<_`z$ SDcMJZ1|Fk|X+NYa_=iI/q@heV3YI&7 n.l#m>W7tsi1a1xJX {.?< .7}z8x?`Y2os !GGU6-Lgk0IUHx'x >V)I^ YQmaI5O@;7m}bq)K=FT_y 5@fBW|9L#+0'@zI$J>4[(Td 3_@s]4?Mu/]PugEg"Cli?mw_`*Z` 1+M,^{6_Fs5B#1DYJdxzBg5j.yW-1K>*IRsi"%|DL? IW3$%G%7#"%Lin:eE0ImW$B`$d-YdKDv#MlP7 {&Bn lB6'iXKn z&t)rfb%6 KQ~K.6|I_.p^Hl*9P j$>B^,bs>kl0KITZR0zZ|n#/{XZ&cR7R'1QoQ%y/ qHI3@gZNw4Ut6v bVohnHj! l7C%?Kjt'_n|g`eXY]Y'[B.[/%$boPbjEy"Fx!x(5j(i,ibv^tl"M0r>F^_bC(YQ +I6CAI)'itf)wpza2c.Eq6X;r2y&O2NQ7m7@hwV9X*v0B=4y+I,pU?c 5bg]#;G} 6BWhJU! FC=+7mGC[2Yhjg#GPqLP,diCLfMj(&-"QwPRDb8 -Y*M RTr!wI!4)!:OrU#Vasqb% _II*qVZ.VOH&k:y&~Ix()m2R+@a$iMJ59D0LH{0Pr4uTG`kQC,5'RCm*jR@N*fCt(%X!7n= 8bC%knnqi#MsBSL|Zko!9@W~l T(S7lj8#PR01sm 6Ove5Kw7Sx["8J.J,Y{j?*y-]~F3Ncw^->k=;?wkZ3&09

See the original post here:

You Can Get Your Whole Genome Sequenced. But Should You? - WIRED

Fast, Precise Cancer Care Is Coming to a Hospital Near You – WIRED

F(zbH"dko[S$T (e"||Y+ AdUHrhx"_WMkpO^i1^pU|T5A;RQg*Z/M <9+JWS=-6e^T&WIc~D?N$Kzm@YQ%QJw&`m3uiDmWy&;{V`Iv[xD{[()v)> *|d35}bBs^+?l<9*)x|rWy9'A`[iLlfsf;g<3 cde9~B+tM1GdJ4"@%*LZ&? L^ef} S`se=hwa4?5/M}s'|t"y,x^Wg6OX?D4zt"q-x/iLxEzW# %=_O&;yrB #Ybdzdfl_=s](paNAG_MN}5:Pbq1;0ka3 :Y6I<)OE+,uc#XeAb2'O~"@DV?yZ_7]'O~Xq)~yO}oTirO~TieU$Q5z'h*bS@ }oGg8;F#XFObdWW,'_v2?_MzWg)f^,ag5v&PnHMir1?B#?"5_'?> s%m_;]q_Ob_&,gIR= y_4~|dq:iOaq43N>0o~P+>VHE@De4v@_5_OdD-glJ's_OF*8ICHNiBdg11{5gnW=|uN~hB(@9nDlDziX#;q8G@oA|>h?deiZ;qzlc,l]g+f&Xl4ZKc [/vh&y9:,no# S6AB>v{ q=?BH;d'Pn4a';;H9@]NPWP~^w^h^*K`]oei)vm=6vrN ~KK ]MFs]t&<.H"I#K![~|DCr/7,wp,C|H|~o)sdnG)cteM>h!GXvuc; U(3G{Go_G>LeXCl~ ^'Yi[~@C?6o?k2T:} Khd}wJ-l}qkzXWWgIi`Qm7.e#c2[T [^u| ZABa4w,oER= ^Wb_mRZ7%^oz0 z2;BHs>v}

Link:

Fast, Precise Cancer Care Is Coming to a Hospital Near You - WIRED

Catalyst for genetic kidney disease in black people identified – Medical Xpress

June 26, 2017 Credit: CC0 Public Domain

Between 15 and 20 percent of black people carry a genetic mutation that puts them at risk for certain chronic kidney disease, but only about half of them develop the illness - a variance that long has puzzled researchers. Now a study has found that the gene mutation's toxic effects require higher than normal levels of a protein called suPAR to trigger the onset and progression of the disease.

The results of the study, published in a research article in the journal Nature Medicine today, could lead soon to new treatments for chronic kidney disease that target these risk factors, according to Dr. Jochen Reiser, the senior author of the paper. Reiser is the chairperson of the Department of Internal Medicine and Ralph C. Brown MD Professor of Medicine at Rush University Medical Center, Chicago.

Chronic kidney disease - or CKD for short - is a progressive failure of function that prevents kidneys from fulfilling their role filtering waste from the blood stream. Nearly 17 percent of people in the U.S. have chronic kidney disease, and approximately 4 percent require dialysis and/or a kidney transplant due to kidney failure. Currently, there are no drugs that can treat CKD in an effective way.

Study analyzed samples from more than 1,000 people with genetic risk for CKD

For the study recounted in the Nature Medicine paper, Reiser worked with a team that included researchers at Emory University, Harvard University, Johns Hopkins University, the National Institute of Health, Ruprecht Karls University of Heidelberg, the Israel Institute of Technology and others. Together, they looked at two well-known genetic risk factors for CKD in black people, the mutated G1 or G2 variations in the gene known as apolipoprotein L1 (APOL1). To be at risk for developing CKD, an individual must have inherited two of these gene variants, one from each parent.

The study analyzed blood samples for suPAR levels, screened for APOL1 gene mutations and measured kidney function from two separate cohorts of black patients - 487 people from the Emory Cardiovascular Biobank, 15 percent of whom had a high-risk APOL1 genotype; and 607 from the multi-center African American Study of Kidney Disease and Hypertension, including 24 percent with the high-risk mutation.

Using these two large, unrelated cohorts, the researchers found that plasma suPAR levelsindependently predict renal function decline in individuals with two copies of APOL1 risk variants. APOL1-related risk is reduced by lower levels of plasma suPAR and strengthened by higher levels.

The team then went on and used purified proteins to study if suPAR and APOL1 bind to each other. They found that the mutated G1 and G2 variant did so particularly well on what's known as a receptor on the surface of kidney cells, in this case the suPAR activated receptor alphavbeta3 integrin. "This binding appears to be a key step in the disease onset" adds Dr. Kwi Hye Ko, a scientist at Rush and the study's co-first author.

This binding causes kidney cells to change their structure and function, permitting disease onset. Using cell models and genetically engineered mice, the authors then could reproduce kidney disease changes upon expression of APOL1 gene variants, but the disease required the presence suPAR.

Without elevated suPAR levels, genetic mutation much less likely to trigger disease

Everybody has suPAR, which is produced by bone marrow cells, in their blood, with normal levels around 2400 picogram per milliliter (pg/ml). As levels of suPAR rise, risk for kidney disease rises in turn.

Patients with levels above 3000 picogram per milliliter carry a much higher risk for kidney disease in the general population. Black people are particularly at risk, given the study's finding that suPAR activates its receptor on kidney cells that then attract the APOL1 risk proteins. Over time, these assaults can damage and eventually destroy the kidney.

On the other hand, without high levels of suPAR, the ability of the genetic mutation of APOL1 to exert its damaging effects is impaired, which helps identify patients in most need of suPAR lowering or future anti-suPAR therapy.

"Patients with APOL1 mutations who don't get kidney disease have more commonly low suPAR levels," said Dr. Salim Hayek, co-first author of the paper and a cardiologist at Emory University School of Medicine. "The suPAR level needs to be high to activate the mechanism in the kidney that enables APOL1 proteins" and set off the chain of events the genetic mutation can trigger.

suPAR 'is to the kidneys as cholesterol is to the heart'

Like some other pathological gene mutations, the APOL1 variations may have persisted in the population, in this case in Africa, because they could protect people from infection with the parasites known as trypanosome. explained Sanja Sever, PhD, co-correspondent author of the paper and associate professor of medicine at Harvard Medical School. In the United States, however, fighting parasitic trypanosomes isn't a significant concern, while lifestyle and environmental pressures such as obesity promote the rise in suPAR levels. This scenario sets up people for high risk of kidney disease.

Reiser has spent his career studying a scarring type of chronic kidney disease, focal segmental glomerulosclerosis. In past studies, he discovered that suPAR not only is a marker for kidney disease, but also a likely cause.

"What we are learning today is that suPAR in a general way is to kidneys what cholesterol is to the heart, a substance that can cause damage if levels rise too high, or a substance that can likely make many forms of kidney disease worse," Reiser says. "Based on these fundamental insights, suPAR level testing may become a routine test at many institutions around the world."

Like cholesterol, suPAR levels vary from person to person. Some environmental factors can contribute significantly to elevated suPAR levels. "Lifestyle is a big factor, bigger than we thought," Reiser says.

Smoking, weight gain and even frequent infections can add up and send suPAR to dangerous heights. Weight loss and smoking cessation can help bring levels down, but once elevated, suPAR may not recede to a healthy level again, said Dr. Melissa Tracy, co-author of the study and an associate professor of cardiology at Rush. People at genetic risk for kidney disease should aim to live a healthy life to keep suPAR levels low.

Explore further: Circulating blood factor linked with a leading cause of kidney failure

More information: A tripartite complex of suPAR, APOL1 risk variants and v3 integrin on podocytes mediates chronic kidney disease, Nature Medicine (2017). DOI: 10.1038/nm.4362

Patients with a disease that is a leading cause of kidney failure tend to have high levels of a particular factor circulating in their blood, according to a study appearing in an upcoming issue of the Journal of the American ...

A protein known as suPAR has been identified in recent years as both a reliable marker for chronic kidney disease and a pathogen of the often deadly condition. Its place of origin in the human body, however, has been a mysteryuntil ...

Make room, cholesterol. A new disease marker is entering the medical lexicon: suPAR, or soluble urokinase-type plasminogen activator receptor. A study in the New England Journal of Medicine shows that suPAR, a circulating ...

African Americans have a heightened risk of developing chronic and end-stage kidney disease. This association has been attributed to two common genetic variants - named G1 and G2in APOL1, a gene that codes for a human-specific ...

New research investigates the ties between certain genetic variants and kidney disease in African Americans. The findings, which appear in an upcoming issue of the Journal of the American Society of Nephrology (JASN), suggest ...

Transplanted kidneys may not function long-term if they come from donors with variants in a particular gene, according to a study that will be presented at ASN Kidney Week 2014 November 11-16 at the Pennsylvania Convention ...

Between 15 and 20 percent of black people carry a genetic mutation that puts them at risk for certain chronic kidney disease, but only about half of them develop the illness - a variance that long has puzzled researchers. ...

For many Americans, the warmer weather of summer means more time spent outside: More gardening and yard work, more hikes in the woods, more backyard barbecues. But for this year in particular, some experts predict warmer ...

Washing hands after using compost could protect gardeners from contracting a common but dangerous strain of Legionnaire's disease, new University of Otago research shows.

A newly discovered antibiotic, produced by bacteria from a cystic fibrosis patient, could be used to treat cases of drug-resistant tuberculosis (TB). This is the finding of a team of scientists from Cardiff University's School ...

Red Cross volunteers prevented a significant number of Ebola cases during the 2013-2016 epidemic in west Africa by using safe burial techniques, according to a study released Thursday.

"Yarraman flu is a virus quickly infecting the U.S. ...." The mock announcement was enough to make readers worry. But when the name of the hypothetical illness was changed to "horse flu", the news elicited a different reaction. ...

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Read the rest here:

Catalyst for genetic kidney disease in black people identified - Medical Xpress

Characterizing the mouse genome reveals new gene functions and their role in human disease – Medical Xpress

June 26, 2017 Credit: CC0 Public Domain

The first results from a functional genetic catalogue of the laboratory mouse has been shared with the biomedical research community, revealing new insights into a range of rare diseases and the possibility of accelerating development of new treatments and precision medicine.

The research, which generated over 20 million pieces of data, has found 360 new disease models and provides 28,406 new descriptions of the genes' effects on mouse biology and disease. The new disease models are being made available to the biomedical community to aid their research.

The International Mouse Phenotyping Consortium (IMPC) is aiming to produce a complete catalogue of mammalian gene function across all genes. Their initial results, now published in Nature Genetics, is based on an analysis of the first 3,328 genes (15 per cent of the mouse genome coding for proteins).

Lead author Dr Damian Smedley from Queen Mary University of London (QMUL) and a Monarch Initiative Principal Investigator, said: "Although next generation sequencing has revolutionised the identification of new disease genes, there is still a lack of understanding of how these genes actually cause disease.

"These 360 new disease models that we've identified in mice represent the first steps of a hugely important international project. We hope researchers will be able to use this knowledge to develop new therapies for patients, which is ultimately what we're all striving to achieve."

With its similarity to human biology and ease of genetic modification, the laboratory mouse is arguably the preferred model organism for studying human genetic disease. However, the vast majority of the mouse genome remains poorly understood, as scientists tend to focus their research on a few specific areas of the genome linked to the most common inherited diseases.

Development of therapies for rare disease lags far behind, with over half of diagnosed rare diseases still having no known causative gene. This is why the IMPC is aiming to build a complete database that systematically details the functions of all areas of the mouse genome, including neurological, metabolic, cardiovascular, respiratory and immunological systems.

Terry Meehan, IMPC Project Coordinator at European Bioinformatics Institute (EMBL-EBI) said: "Mouse models allow us to speed up patient diagnosis and develop new therapies. But before that can work, we need to understand exactly what each gene does, and what diseases it is associated with. This is a significant effort in data collection and curation that goes well beyond the capabilities of individual labs. IMPC is creating a data resource that will benefit the entire biomedical community."

The project involves going through the mouse genome systematically and knocking out a particular gene, one by one, in different mice. By looking at the mouse's resulting characteristics in a variety of standardised tests, the team then see if and how the gene knockout manifests itself as a disease, and link their findings to what is already known about the human version of the disease. The 'one by one' knockout approach lends itself to rare gene discovery, as often these diseases are caused by variants of a single gene.

More than half of the 3,328 genes characterised have never been investigated in a mouse before, and for 1,092 genes, no molecular function or biological process were previously known from direct experimental evidence. These include genes that have now been found to be involved in the formation of blood components (potentially involved in a type of anaemia), cell proliferation and stem cell maintenance.

For the first time, human disease traits were seen in mouse models for forms of Bernard-Soulier syndrome (a blood clotting disorder), Bardet-Biedl syndrome (causing vision loss, obesity and extra fingers or toes) and Gordon Holmes syndrome (a neurodegenerative disorder with delayed puberty and lack of secondary sex characteristics).

The team also identified new candidate genes for diseases with an unknown molecular mechanism, including an inherited heart disease called 'Arrhythmogenic Right Ventricular Dysplasia' that affects the heart muscle, and Charcot-Marie-Tooth disease, which is characterised by nerve damage leading to muscle weakness and an awkward way of walking.

Dr Smedley added: "In addition to a better understanding of the disease mechanism and new treatments for rare disease patients, many of the lessons we learn here will also be of value to precision medicine, where the goal is to improve treatment through the customisation of healthcare based on a patient's genomic information."

Explore further: Major mouse study reveals the role of genes in disease

More information: 'Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium' by Meehan et al., Nature Genetics. DOI: 10.1038/ng.3901

The functions of around 150 genes have been discovered by scientists across Europe in a major initiative to try to understand the part they play in disease and biology.

Roughly a third of all genes in the mammalian genome are essential for life. A new article in Nature, from an international, multi-institutional research team, including Baylor College of Medicine, describes the large-scale ...

The first known identification of two genes responsible for hypoplastic left heart syndrome (HLHS), a severe congenital heart defect, has been reported by researchers at the University of Pittsburgh School of Medicine. The ...

An international team of researchers has discovered that mutations in the human gene CWC27 result in a spectrum of clinical conditions that include retinal degeneration and problems with craniofacial and skeletal development. ...

An international team of researchers from institutions around the world, including Baylor College of Medicine, has discovered that mutations of the OTUD6B gene result in a spectrum of physical and intellectual deficits. This ...

Researchers have created a large new resource of more than 900 genes switched off one-at-a-time in mice to discover which genes are important for a wide range of biological functions such as fertility or hearing.

Whole genome sequencing involves the analysis of all three billion pairs of letters in an individual's DNA and has been hailed as a technology that will usher in a new era of predicting and preventing disease. However, the ...

The first results from a functional genetic catalogue of the laboratory mouse has been shared with the biomedical research community, revealing new insights into a range of rare diseases and the possibility of accelerating ...

Researchers have found that genes for coronary heart disease (CAD) also influence reproduction, so in order to reproduce successfully, the genes for heart disease will also be inherited.

When Ricky Ramon was 7, he went for a routine checkup. The pediatrician, who lingered over his heartbeat, sent him for a chest X-ray, which revealed a benign tumor in the top-left chamber of his heart. For Ramon, it was the ...

Gene mutations accumulating in cells are typical of the development of cancer. Finnish researchers have found that a similar accumulation of mutations occurs also in some patients with rheumatoid arthritis.

Up to 90 percent of people with amyotrophic lateral sclerosis (ALS) report that they have no family history of the disease. Now, new research has found approximately 17 percent of such ALS cases may be caused by a gene mutation, ...

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Read the original here:

Characterizing the mouse genome reveals new gene functions and their role in human disease - Medical Xpress

Cloning thousands of genes for massive protein libraries – Phys.Org

June 26, 2017 New DNA-based LASSO molecule probe can bind target genome regions for functional cloning and analysis. Credit: Jennifer E. Fairman/Johns Hopkins University

Discovering the function of a gene requires cloning a DNA sequence and expressing it. Until now, this was performed on a one-gene-at-a-time basis, causing a bottleneck. Scientists at Rutgers University-New Brunswick in collaboration with Johns Hopkins University and Harvard Medical School have invented a technology to clone thousands of genes simultaneously and create massive libraries of proteins from DNA samples, potentially ushering in a new era of functional genomics.

"We think that the rapid, affordable, and high-throughput cloning of proteins and other genetic elements will greatly accelerate biological research to discover functions of molecules encoded by genomes and match the pace at which new genome sequencing data is coming out," said Biju Parekkadan, an associate professor in the Department of Biomedical Engineering at Rutgers University-New Brunswick.

In a study published online today in the journal Nature Biomedical Engineering, the researchers showed that their technologyLASSO (long-adapter single-strand oligonucleotide) probescan capture and clone thousands of long DNA fragments at once.

As a proof-of-concept, the researchers cloned more than 3,000 DNA fragments from E. coli bacteria, commonly used as a model organism with a catalogued genome sequence available.

"We captured about 95 percent of the gene targets we set out to capture, many of which were very large in DNA length, which has been challenging in the past," Parekkadan said. "I think there will certainly be more improvements over time."

They can now take a genome sequence (or many of them) and make a protein library for screening with unprecedented speed, cost-effectiveness and precision, allowing rapid discovery of potentially beneficial biomolecules from a genome.

In conducting their research, they coincidentally solved a longstanding problem in the genome sequencing field. When it comes to genetic sequencing of individual genomes, today's gold standard is to sequence small pieces of DNA one by one and overlay them to map out the full genome code. But short reads can be hard to interpret during the overlaying process and there hasn't been a way to sequence long fragments of DNA in a targeted and more efficient way. LASSO probes can do just this, capturing DNA targets of more than 1,000 base pairs in length where the current format captures about 100 base pairs.

The team also reported the capture and cloning of the first protein library, or suite of proteins, from a human microbiome sample. Shedding light on the human microbiome at a molecular level is a first step toward improving precision medicine efforts that affect the microbial communities that colonize our gut, skin and lungs, Parekkadan added. Precision medicine requires a deep and functional understanding, at a molecular level, of the drivers of healthy and disease-forming microbiota.

Today, the pharmaceutical industry screens synthetic chemical libraries of thousands of molecules to find one that may have a medicinal effect, said Parekkadan, who joined Rutgers' School of Engineering in January.

"Our vision is to apply the same approach but rapidly screen non-synthetic, biological or 'natural' molecules cloned from human or other genomes, including those of plants, animals and microbes," he said. "This could transform pharmaceutical drug discovery into biopharmaceutical drug discovery with much more effort."

The next phase, which is underway, is to improve the cloning process, build libraries and discover therapeutic proteins found in our genomes, Parekkadan said.

Explore further: Technical advances in reading long DNA sequences have ramifications in understanding primate evolution, human disease

More information: Long-adapter single-strand oligonucleotide probes for the massively multiplexed cloning of kilobase genome regions, Nature Biomedical Engineering (2017). DOI: 10.1038/s41551-017-0092

Technical advances in reading long DNA sequences have ramifications in understanding primate evolution and human disease.

The most popular varieties of teaincluding black tea, green tea, Oolong tea, white tea, and chaiall come from the leaves of the evergreen shrub Camellia sinensis, otherwise known as the tea tree. Despite tea's immense ...

(Phys.org)For the first time, researchers sequenced DNA molecules without the need for the standard pre-sequencing workflow known as library preparation.

An international team of computer scientists developed a method that greatly improves researchers' ability to sequence the DNA of organisms that can't be cultured in the lab, such as microbes living in the human gut or bacteria ...

A new approach to studying microbes in the wild will allow scientists to sequence the genomes of individual species from complex mixtures. It marks a big advance for understanding the enormous diversity of microbial communities ...

With the rapid rise of next-generation sequencing technologies, disparate fields from cancer research to evolutionary biology have seen a drastic shift in the way DNA sequence data is obtained. It is now possible to sequence ...

Since at least the 1920s, anecdotes and some studies have suggested that chimpanzees are "super strong" compared to humans, implying that their muscle fibers, the cells that make up muscles, are superior to humans.

In his classic comedy routine, "A Place for your Stuff," George Carlin argues that the whole point of life is to find an appropriately sized space for the things you own. What holds for people is also true for bacteria.

Researchers at the RIKEN Center for Sustainable Resource Science (CSRS) have discovered a new, yet simple, way to increase drought tolerance in a wide range of plants. Published in Nature Plants, the study reports a newly ...

Over two million years ago, a third of the largest marine animals like sharks, whales, sea birds and sea turtles disappeared. This previously unknown extinction event not only had a consid-erable impact on the earth's historical ...

Mammals possess several lines of defense against microbes. One of them is activated when receptors called Fprs, which are present on immune cells, bind to specific molecules that are linked to pathogens. Researchers at the ...

When Mark Martindale decided to trace the evolutionary origin of muscle cells, like the ones that form our hearts, he looked in an unlikely place: the genes of animals without hearts or muscles.

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Read this article:

Cloning thousands of genes for massive protein libraries - Phys.Org

Insomnia May Be A Partly Genetic Condition – IFLScience

Do you lie awake at night, wishing you could sleep for hours on end? Do you toss and turn, raging against your inability to enter the land of dreams? Worrying about the end of the world aside, your lack of snoozes could be down to your parents and their pesky genetics.

Were not talking about a few hours of sleep lost here and there, by the way. Were referring to full-blown insomnia, which can last for months or even years at a time. It has a number of causes, including anxiety, a bad sleeping environment, physical and mental health conditions, and adverse reactions to medication.

There have been hints that there are genetic markers that make someone predispositioned towards suffering from insomnia too, but a new study in Nature Genetics gives more credence to the idea than ever before.

A team from Vrije Universiteit Amsterdam (VU) have found seven risk genes in a sample of 113,006 individuals that make someone more likely but not certain to suffer from insomnia compared to those that lacked the genes. These genes arent directly related to sleep patterns, but rather their presence creates an unintended side-effect that appears to trigger sleep loss.

The primary purpose of these genes is two-fold: to read DNA and make RNA copies, and to allow cells to release signaling molecules so that they can communicate with their environment. For some reason, their existence appears to overlap with an increased risk of several conditions, including anxiety disorders, depression, neuroticism, perceived lack of wellbeing, educational difficulties, and insomnia.

The team note that one of these risk genes, MEIS1, has been found on previous occasions to be related to restless legs syndrome and periodic limb movements of sleep. These are characterized by sporadic physical movements, whereas insomnia is of course typified by a disruptive state of consciousness.

Curiously, the risk genes and the associated insomnia was more prevalent in men (33 percent of sample) than women (24 percent of the sample). At present, this discrepancy has no known explanation.

This suggests that, for some part, different biological mechanisms may lead to insomnia in men and women, co-author Danielle Posthuma, a professor of statistical genetics at VU, said in a statement.

In short, theres still a lot we dont know about insomnia, but this study suggests that genes inherited from your parents play a larger role than previously thought. In several people, its likely that their affliction is not a purely psychological condition.

In any case, severe insomnia brings with it a heavy mental and physical toll. If it gets serious enough, you shouldnt rely on sleeping pills every night go and see a clinical practitioner tofind out what they recommend.

Originally posted here:

Insomnia May Be A Partly Genetic Condition - IFLScience

Study reveals how sex ‘blindspot’ could misdirect medical research – Medical Xpress

June 26, 2017 Credit: martha sexton/public domain

The sex of animals frequently has an effect in biomedical research and therefore should be considered in the study of science, report scientists from the Wellcome Trust Sanger Institute and the International Mouse Phenotyping Consortium. In the largest study of its kind, researchers found that the differences between male and female mice had an effect that could impact research results in more than half of their studies.

The study, published today (26 June) in Nature Communications, quantified the differences between males and females - known as sexual dimorphism. The results have implications for the design of future animal studies which underpin research into treatments for human diseases.

Historically, a woman has been thought of as a small man in medicine and biomedical research. Even today, medical practice is less evidence-based for women than for men due to a bias towards the study of males in biomedical research.

Sex influences the prevalence, course and severity of the majority of common diseases and disorders, including cardiovascular diseases, autoimmune diseases and asthma. In spite of this, the usual approach in biomedical research is to ignore sex or to analyse only one sex and assume the results apply to the other sex.

In this new study, researchers have quantified the difference between male and female mice, looking across multiple experiments and institutes. In the largest study of its kind, scientists analysed up to 234 physical characteristics of more than 50,000 mice.

The team found that in the standard group of mice - the control mice - their sex had an impact on 56.6 per cent of quantitative traits, such as bone mass, and on 9.9 per cent of qualitative traits, including whether the shape of the head was normal or abnormal. In mice that had a gene switched off - the mutant mice - their sex modified the effect of the mutation in 13.3 per cent of qualitative traits and up to 17.7 per cent of quantitative traits.

Dr Natasha Karp, lead author who carried out the research at the Wellcome Trust Sanger Institute, and now works in the IMED Biotech Unit at AstraZeneca, said: "This was a scientific blindspot that we really thought needed exploration. A person's sex has a significant impact on the course and severity of many common diseases, and the consequential side effects of treatments - which are being missed. Now we have a quantitative handle on how much sexual dimorphism has an impact in biomedical research. In the movement towards precision medicine, we not only have to account for genetic differences between people when we consider disease, but also their sex."

In the study, scientists analysed 14,250 control mice and 40,192 mutant mice from 10 centres that are part of the International Mouse Phenotyping Consortium (IMPC). At each institution, scientists studied up to 234 physical characteristics of the mice, including body composition, metabolic profile, blood components, behavioural traits and whole body characterisation - whether the head shape, coat, paws and other areas of their bodies were normal or abnormal.

In the first half of the study, scientists studied the differences between the physical traits of control male and female mice to see if their sex had an effect.

In the second part of the study, scientists then looked at how the sex of a mouse impacted on the effect of a genetic modification. For example, researchers switched off a gene and assessed whether any differences in the resulting trait depended on the sex of the mice.

Professor Judith Mank, an author of the study from University College London, said: "This study illustrates how often sex differences occur in traits that we would otherwise assume to be the same in males and females. More importantly, the fact that a mouse's sex influenced the effects of genetic modification indicates that males and females differ right down to the underlying genetics behind many traits. This means that only studying males paints half the picture."

This study presents implications for the design of future animal studies and clinical trials. It has been more than twenty years since it became a requirement that women were included within clinical trials in the US. Whilst more women are taking part in clinical trials, increasing from 9 per cent in 1970 to 41 per cent 2006, women are still under-represented.

The bias is even stronger in the earlier stages of biomedical research. A review of international animal research between 2011 and 2012 found that 22 per cent of studies did not state the sex of the animals, and of those that did, 80 per cent of studies used solely males and only 3 per cent included both males and females.

Professor Steve Brown, an author of the study who is Director of the MRC Harwell Institute and Chair of the International Mouse Phenotyping Consortium Steering Committee, said: "It is likely that important scientific information is missed by not investigating more thoroughly how males and females differ in biomedical research. Rather than extrapolate the results to account for the opposite sex, these results suggest designing experiments to include both sexes in the study of disease. This study is a major step to highlighting the impact of sex differences in research and will help in accounting for those differences in the future of biomedicine."

Explore further: Lab mice may not be effective models for immunology research

More information: Natasha Karp et al. (2017) Prevalence of sexual dimorphism in mammalian phenotypic traits. Nature Communications. DOI: 10.1038/NCOMMS15475

Trying to pinpoint signals from individual neurons within a block of brain tissue is like trying to count headlights in thick fog. A new algorithm, developed by researchers based at The Rockefeller University, brings this ...

When women undergo lumpectomies to remove breast cancer, doctors try to remove all the cancerous tissue while conserving as much of the healthy breast tissue as possible.

The sex of animals frequently has an effect in biomedical research and therefore should be considered in the study of science, report scientists from the Wellcome Trust Sanger Institute and the International Mouse Phenotyping ...

Researchers have identified a possible new treatment for gonorrhea, using a peptide that thwarts the infection-causing bacterium by interfering with an enzyme the microbe needs to respirate.

Your brain is armored. It lives in a box made of bones with a security system of vessels. These vessels protect the brain and central nervous system from harmful chemicals circulating in the blood. Yet this protection systemknown ...

Discovered more than two decades ago, the hormone leptin has been widely hailed as the key regulator of leanness. Yet, the pivotal experiments that probe the function of this protein and unravel the precise mechanism of its ...

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

See original here:

Study reveals how sex 'blindspot' could misdirect medical research - Medical Xpress

How Exercise May Protect the Brain From Alzheimer’s Disease – TIME

Regular exercise may offer some protection against Alzheimer's disease, even for people who are genetically at risk, according to recent research.

In the study, published in the Journal of Alzheimers Disease, people who did more moderate-intensity physical activity were more likely to have healthy patterns of glucose metabolism in their brainsa sign of healthy brain activitythan those who did less. Light-intensity physical activity, on the other hand, was not associated with similar benefits.

The study involved 93 adults with an average age of 64, all of whom had at least one parent with Alzheimers disease, at least one gene variation linked to Alzheimers disease, or both. This put them at high risk for developing the disease themselves, although none showed any cognitive impairment at the time of the study.

To illuminate the relationship between brain activity and exercise levels, everyone wore an accelerometer for a week to measure their daily physical activity and received PET scans to measure glucose metabolism, which reveals neuron health and activity, in several regions of the brain. For people with Alzheimers disease, these regions tend to have depressed glucose metabolism.

Researchers found that people who spent at least 68 minutes a day engaged in physical activity at a moderate levelthe equivalent of a brisk walkhad better glucose metabolism in all of those regions than those who spent less time doing so.

The amounts of time spent being sedentary or doing less-intense physical activity (like slow walking) were not associated with changes in any of the brain regions studied. Vigorous activity was linked to better glucose metabolism in one brain regionthe hippocampus but not in the others.

Larger doses of high-intensity exercise may be needed to provide the benefits of just a modest increase in moderate activity, the authors wrote, suggesting that you don't have to exercise to the extreme to get brain benefits. Past research comparing the brain-boosting power of moderate- and vigorous-intensity exercise has been mixed, says lead author Ozioma Okonkwo, assistant professor of medicine at the University of Washington School of Medicine and Public Health. But in general, he says, the evidence suggests that light activity is insufficient, and vigorous activity might be unnecessary.

Being able to quantify the connection between moderate-intensity activity and brain health is an exciting and important step in Alzheimers research, the researchers say, although further studies are needed in order to show a cause-and-effect relationship between exercise and glucose metabolismand to demonstrate real-life benefits. (The team is currently recruiting people with concerns about their brain health for a clinical trial to help determine the right dose of exercise for people with mild memory problems.)

But Okonkwo points out that previous research has already established a connection between glucose metabolism and cognitive function. Were showing now that a moderate-intensity active lifestyle actually boosts neuronal function, he says. "I dont think its too much of a leap to make the argument that this probably is one of the pathways through which exercise prevents cognitive decline in middle life.

Okonkwo says this research offers reassurance that people can take steps to protect themselves against Alzheimers disease, even if they are at high genetic risk. The evidence shows that its never too late to take up and maintain a physically active regimen, he says. It also suggests that the earlier you begin and the longer you continue it, the more benefits you tend to accrue.

More:

How Exercise May Protect the Brain From Alzheimer's Disease - TIME

Genetic Engineering | IPTV

Genetic engineering has the potential to change the way we live. The science behind the agricultural, medical, and environmental achievements is spectacular, but this excitement is tempered by concern for the unknown effects of tampering with nature. How should we use genetic engineering?

DNA is the root of all inheritance and the key to understanding the basics of all biological inheritance and genetics.

The possibilities of this genetic engineering are endless, and everyone from medicine to industry is scrambling to adopt it and adapt it to their specific needs.

Genetic engineering changes or manipulates genes in order to achieve specific results, and there are many ways to "engineer" genetic material including fixing defective genes, replacing missing genes, copying or cloning genes, or combining genes.

How is genetic engineering used in food production? What political, environmental, and production obstacles could arise in the effort to label genetically engineered foods? What food traits would you like to see genetically engineered?

How could GE help in meeting growing demand for food around the world?

How can GE be used with animals? What are the benefits and risks of using genetic engineering with livestock or with endangered or extinct animals?

How does cloning work? What situations might be viewed as ethical uses of human cloning? Unethical?

What are the potential consequences, positive and negative, of discovery in the genetic engineering field? Who should be involved in determining the ethical limitations of the uses of genetic engineering?

Produced from 2001 through 2004, Iowa Public Television's Explore More online and broadcast series engages students in problems they can relate to, provides compelling content for investigation and gives students opportunities to form their own points of viewon contemporary issues.

Although the full website has been retired, this archive provides links to project videos and related resources. Please contact us if you have questions or comments about Explore More.

See more here:

Genetic Engineering | IPTV

Letter: GMO article was filled with misinformation – Mountain Xpress

I was very disappointed by your recent story about genetic engineering [Facts, Fears and the Future of Food, May 17, Xpress]. This article is full of misinformation, and it may as well have been written by a Monsanto lobbyist. Your newspaper poses as an open-minded, environmentally conscious, liberal organization but this article clearly shows where your loyalties lie. Whos writing the check for this one?

Please check your alternate facts about the safety of glyphosate and other toxic chemicals that are polluting our land, our water and our bodies. And check your statistics on world pesticide use, as the U.S. does notrank 43rd in the world for use of pesticides.

Good journalism requires an unbiased approach, and your interviews with local pro-GMO scientists were appropriate. However, you offered no rebuttal to the information provided by these interviewees.

Putting false information and statistics into quotations does not absolve you of any wrongdoing.

Devin Crow Barnardsville

Freelance writer Nick Wilson responds: With this piece, I was genuinely trying to understand a very controversial and complex issue. During my research process, I became aware of my own ignorance in regard to much of the actual science behind genetic engineering. I found my conversations with folks like Jack Britt and Leah McGrath to be informative, thought-provoking, compelling and eye-opening. Throughout my research, it also became apparent to me that theres a lot of public opinion on genetic engineering thats based primarily in emotional rhetoric, rather than in facts. This isnt to claim that certain arguments are right only if they are unemotional, its simply a reason why I felt it was important to focus the article on clarifying some of the common misconceptions about genetic engineering.

If you believe the article contains misinformation, Id love to see more accurate data. I can assure you Im not a Monsanto lobbyist. Im genuinely skeptical of large corporations and voiced reason within the article to be critical of these entities as well as directing readers to check out the local March Against Monsanto protest.

Youre correct in pointing out that the U.S. does not rank 43rd in the world for the use of pesticides. According to data Jack Britt downloaded on June 8 from the Food and Agriculture Organization of the United Nations, it now ranks 42.5, tied with Peru, Austria and Ireland.

I chose to focus the story on the common fears about genetic engineering countered with facts provided by people who are well-versed on the subject in order to showcase a side of the story that, to me, seems to receive less attention in Asheville. My goal was to reveal that its much more than pro-GMO vs. anti-GMO, but a highly complicated issue that needs to be better understood to facilitate more meaningful debate moving forward.

Read the original here:

Letter: GMO article was filled with misinformation - Mountain Xpress

New York Neo-Futurists to Offer ‘Fundamentals’ Workshop This Summer – Broadway World

The award-winning New York Neo-Futurists will share a little of their well earned wisdom this summer when they offer the workshop, Level One: Function and Fundamentals. The workshop that has served as a stepping stone to fifteen would-be Neo-Futurists is a twelve hour workshop that stretches over three Saturdays beginning July 22nd and wrapping up August 5th, all taking place at Playwrights Rehearsal Studios.

Workshop participants will be taught the function and fundamentals of what it means to create art in the Neo-Futurist aesthetic: performing as your most natural self, dismantling the fourth wall, creating task-based theatre, and accessing creative inspiration to eliminate writer's block. By the end of this workshop, participants will have written, performed and workshopped both individually and collectively written short plays that can be taken into the world in whichever way they see fit.

The instructors for this Level One: Function and Fundamentals workshop will be Neo-Futurists Dan McCoy and Connor Sampson. McCoy, a member of the NY Neo-Futurists since 2009 is a performer and playwright who holds an MFA in Playwriting from Hunter College and whose work has been produced or developed recently at Theaterlab, Primary Stages, Project Y Theatre and IATI Theatre. Sampson is a two-time national champion of performance poetry, the 2016 inaugural recipient of the Jeffrey Melnick New Playwright Award (Primary Stages) and has been a Neo since 2014. Connor also holds a BFA with honors in Dramatic Writing from NYU's Tisch School of the Arts.

If you've found yourself in the Kraine Theater at 10:30 on a Friday or Saturday night, witnessed the Neo-Futurists delivering their barrage of short plays, and said to yourself "I can do that" or "I could never do that," then this workshop is for you. Creative individuals at all levels of experience are encouraged to enroll for a mere $300.

The New York Neo-Futurists are a collective of wildly productive writer-director-performers that create theater that is fusion of sport, poetry and living-newspaper; non-illusory, interactive performance that conveys experiences and ideas as directly and honestly as possible; immediate, irreproducible events at affordable prices. Since opening in Brooklyn in 2004 the New York Neo-Futurists have premiered roughly 4,500 plays and have become a downtown New York institution. In addition to performing The Infinite Wrench fifty weeks a year and producing Too Much Light Makes The Baby Go Blind from 2004 until 2016, the New York Neo-Futurists have been a stalwart presence in the Off-Off Broadway community, having won numerous Innovative Theatre Awards and Drama Desk Nominations.

IF YOU GO: New York Neo-Futurists What: Level One Workshop: Function and Fundamentals Where: Playwrights Rehearsal Studios, 440 Lafayette Street #4, New York, NY 10003 When: July 22nd, July 29th & August 5th from 1pm-5pm. How: nynf.org or 866-811-4111 Cost: $300 ($50 deposit to reserve your spot).

Photo Credit: Kari Otero, 2015 (Center)

View original post here:

New York Neo-Futurists to Offer 'Fundamentals' Workshop This Summer - Broadway World

Why a Respected CEO Believes Bitcoin Is a Tool for Freeing Humanity – Futurism

In BriefCould Bitcoin destroy tyranny in the modern world? At leastone person thinks so. Bitcoin Frenzy

Recently, there has been a lot of hype and equally criticism of Bitcoin. The cryptocurrency has, just this far into 2017, jumped well over 100 percent in value, garnering suspicion and questions regarding its potential for long-term success. However, besides these doubts, Naval Ravikant, an investor and the CEO and co-founder of Angel List, has come to Bitcoins defense on Twitter:

Claiming that Bitcoin could free humanity from oligarchs and tyrants Ravikant asserts that the quick rise in value that is making many wary of Bitcoin is just superficial. But how could a cryptocurrency free humanity of tyranny?

Well, through the potential power of blockchain. The blockchain ledger, which includes cryptocurrencies, essentially streamline the financial world. They eliminate a need for a middle-man, so-to-speak, so institutions like banks would no longer be necessary for a society based in blockchain. And while that might seem like a small difference, think about how many different aspects of a modern society rely on even the simplest financial transactions.

Are Ravikants opinions of Bitcoin extreme or off-base? Its impossible to say, as some consider the cryptocurrency to be a bubble about to burst, but the potential blockchain itself has to change the way that societies operate is very real. Its not just a passing phase, as many thought with the emergence of seemingly joke cryptocurrencies like Dogecoin. It is something that, if adopted on a wider scale which has already begun in countries like Japan the authorities whocurrently control consumption and financial transactions would no longer be relevant.

Money makes the world go round. Peace, suffering, conflict, power; so much of modern life centers around transactions. From information to finances, all of these transactions rely on some middle step, some outside authority or management. This has made countless people over the years dependent on these outside power structures, creating control and dominance differences that have the potential to create what could be construed as tyranny.

Now, this might be pushing current boundaries by saying that Bitcoin, just one specific blockchain, could make such a big change. So, one some level, Ravikant is stretching this. Bitcoin itself is still relatively unstable and there is some possibility that its most recent rise in value is a bubble that is certain to eventually burst. It is only one of multiple cryptocurrencies and blockchains, none of which are close to completely taking over any economic structures yet. However, if blockchains potential coupled with Bitcoins popularity eventually leads to such a revolution, perhaps tyranny and oligarchs would truly become obsolete.

More here:

Why a Respected CEO Believes Bitcoin Is a Tool for Freeing Humanity - Futurism

Did NASA Just Discover Alien Life? Spoiler Alert: No. – Futurism

In Brief A Youtuber claiming affiliation with the hactivist group Anonymous released a video stating that NASA is on the verge of announcing the discovery of intelligent life. The video takes quotes out of context and adds their own unproven assumptions. Anonymous Tip

Living in these uncertain times, it seems that false news stories generated to rack up the clicks disseminate faster than ever before. Some of these fake stories even make it beyondthe traditionally susceptible Great Uncles Facebook feed and are quickly gobbled up by traffic-hungry publications who are more concerned with riding a wave of sensationalism than earnestly informing the populace. Such a story had its grips on publications across the internet today, and the salacious topic fueling the frenzy was (of course) aliens.Click to View Full Infographic

A video was posted by a self-describedmember of Anonymous a loosely associated international hacktivist group who claimed that they hadexclusive evidence from NASA saying that we are on the verge of discovering alien life. The person in the Guy Fawkes mask with the digitally-altered voice goes even further, claimingthat theyre not just talking about microbial life, but advanced, space-faring civilizations.

Unfortunately, the facts just do not measure up to these claims which were taken out of context from actual hearings. Keeping in mind thatNASA is certainly making significant progress in discovering life on other planets,The Washington Post decided to do some actual journalism and reach out to NASA for a quote on the fake news. While were excited about the latest findings from NASAs Kepler space observatory, theres no pending announcement regarding Extra-Terrestrial life, a spokesman for the agency wrote.

One of the quotes pulled for the video was said by NASAs Thomas Zurbuchen during a congressional hearing back in April (the entire hearing is publicly available). Zurbuchen did indeed state We are on the verge of making one of the most profound, unprecedented discoveries in history, but he was discussing the discovery of possible habitable planets around distant suns, as well asorganic chemicals being found on a moon of Saturn.

Futurism will continue to follow all leads regarding the search for life beyond Earth but we will do so with the full backing of peer reviewed science and not by taking the word of a viral video.

View original post here:

Did NASA Just Discover Alien Life? Spoiler Alert: No. - Futurism

SpaceX Just Transformed Space Flight, Launching Two Rockets in 48 Hours – Futurism

In Brief A historic weekend "doubleheader" for Elon Musk ended Sunday afternoon after SpaceX launched two payloads into space within 48 hours of each other. The initial launch was also a first for the country of Bulgaria, which launched a telecommunications satellite.

As of 5 p.m. EST, this story is developing.

Elon Musks SpaceX took ascheduling delay and turned it into a historic opportunity: as the result of postponing the launch of a Bulgarian satellite from Monday to Friday of last week, SpaceX had two Falcon 9 rocket launches within 48 hours of each other. Fridays BulgariaSat-1 launch happened from NASAs Kennedy Space Center in Florida. The second one carrying a payload of 10 new satellites from Virginia-based telecommunications company Iridiumlifted off Sunday afternoon from the Vandenberg Air Force Base in California.

The two back-to-backlaunches a first for SpaceX were made possible by its reusable rocket technology. Fridays BulagariaSat-1 launch was only the second time the space venture company successfully reused a rocket booster, while Sundays marked the third. In a series of tweets after the launch, Muskseemed pleased with how far the reusable tech has come.

That being said, it could still be refined even more. As he explainedin his answer to a Twitter userssuggestion, hed like to see the rocket turnaround be so quick there isnt even time enough to touch up the paint job.

Apart from being weekend of firsts for SpaceX, it was also the first time Bulgaria launched a telecommunications satellite. For Iridium, todays payload was the second batchof its planned 70-satellite constellation, which is part of its NEXT mobile communications network. The first 10 of these low-orbit satellites were launched in January.

This weekends doubleheader was a confidence boost for the reusable rocket technology.Among other things, Musk hopes the tech will help lower the overallthe cost of going tospace. Hepreviously highlighted that launching satellites aboard SpaceXs reusable rockets is $300 million cheaper than conventional one-way-trip rockets.

Even before this weekends successes, interest in the reusable rocket tech has been steadily growing: to date, SpaceX has booked more than 50 missions including one from aerospace giant Airbus. Most arescheduled for this year or into 2018.There are a number launches both from private corporations like Iridium, as well as from government agencies, similar toBulgarias arrangement.

Perfecting its reusable rocket technology isnt just going to benefit SpaceX in the short term. Its most exciting potential application could actually be in the bigger rockets that could start ferrying human beings to Mars sometime in the2030s.

See more here:

SpaceX Just Transformed Space Flight, Launching Two Rockets in 48 Hours - Futurism

Researchers Break a 100-Year-Old Fundamental Limitation of Physics – Futurism

In Brief Researchers from the Ecole Polytechnique Federale de Lausanne have managed to break a 100-year-old fundamental law in physics. The breakthrough could influence any technology that relies on resonant system to store information. Breaking Limits

Researchers working at the cole Polytechnique Fdrale de Lausanne (EPFL) have successfully challenged a fundamental law thats limited the physics of storing electromagnetic energy for the past 100 years. This breakthrough, which the researchers have published in the journal Science, frees up physicists and engineers to develop technologies that rely on resonant and wave-guiding systems.

First formulated in 1914, the fundamental principle known as the Lorentz reciprocity posits an inversely proportional relationship between the length of time a wave could be stored to the bandwidth (or the range of frequencies transmitted in a given signal) of resonant or wave-guiding systems. For a resonator to store energy for a longer time, it has to decrease its bandwidth. In other words, limited bandwidth translates to limited data.

The researchers managed to find a work around to the 100-year-old limitation by developing a hybrid resonant/wave-guiding system using a magno-optic material. When a magnetic field is applied, it can contain the wave for a longer period of time, while also maintaining a large bandwidth.

The researchers broke the time-bandwidth restriction by a factor of 1,000 butthey think it may be possible that theres no limit to how high it could go. It was a moment of revelation when we discovered that these new structures did not feature any time-bandwidth restriction at all. These systems are unlike what we have all been accustomed to for decades, and possibly hundreds of years said lead author Kosmas Tsakmakidis in a press release. Their superior wave-storage capacity performance could really be an enabler for a range of exciting applications in diverse contemporary and more traditional fields of research.

By breaking the restriction, the EPFL research will have a major impact on wide range of engineering and physics applications. The reported breakthrough is completely fundamental were giving researchers a new tool. And the number of applications is limited only by ones imagination, Tsakmakidis explained.

These applications could also extend to telecommunications, optical detection systems, and broadband energy harvesting, the press release noted. Essentially, any technology that uses waves to store information now has accessto a wider bandwidth. That could be anything from on-chip spectroscopy, light harvesting and energy storage using broadband to broadband optical camouflaging such asan invisibility cloak.

More:

Researchers Break a 100-Year-Old Fundamental Limitation of Physics - Futurism

The Supreme Court’s Religious-Freedom Message: There Are No Second-Class Citizens – National Review

While there are many threats to religious liberty, few are more consequential over the long term than the states ever-expanding role in private life. If the government is able to vacuum up tax dollars, create programs large and small for public benefit, and then exclude religious individuals or institutions from those programs, it has functionally created two tiers of citizenship. Secular individuals and institutions enjoy full access to the government they fund, while religious individuals and institutions find themselves funding a government that overtly discriminates against them.

Thats the issue the Supreme Court addressed today in Trinity Lutheran Church v. Comer. By a 72 margin, the Court held that when a state creates a neutral program for public benefit in this case a program that uses scrap tires to provide rubberized safety flooring for playgrounds it cant exclude a church from that program, even if that means state benefits flow directly to a house of worship. Justice Roberts, writing for the majority, was emphatic:

The Missouri Department of Natural Resources has not subjected anyone to chains or torture on account of religion. And the result of the States policy is nothing so dramatic as the denial of political office. The consequence is, in all likelihood, a few extra scraped knees. But the exclusion of Trinity Lutheran from a public benefit for which it is otherwise qualified, solely because it is a church, is odious to our Constitution all the same, and cannot stand.

The Courts holding secured by my friends and former colleagues at the Alliance Defending Freedom is significant for two reasons. First, it places another brick in a wall of precedent that stands for the proposition that once the state creates a neutral program one designed neither to advance nor to inhibit religious practice it cant exclude citizens or institutions from that program merely because theyre religious. Under these precedents, churches are able to worship in government buildings, religious student groups may access student activity fees to fund their campus outreach, parents may send their children to religious schools with publicly funded vouchers, and hosts of religious organizations may participate in public/private partnerships to serve our nations poorest and most vulnerable citizens. So entrenched is this precedent that it would have been a legal earthquake had the Court ruled against the church.

Second, seven of the nine justices concurred in the result of the case. This means that the principle of religious nondiscrimination in public programs has broad judicial support. Indeed, in recent years the Court has decided a number of significant religious-freedom cases unanimously or with overwhelming majorities. Yes, the Hobby Lobby case was a classically contentious 54 ruling, but other significant cases (such as Hosanna-Tabor v. EEOC which kept the government out of significant church-hiring decisions and Little Sisters of the Poor) achieved consensus.

Constitutional doctrine is usually created not by a judicial grand slam but rather through a long series of singles, stolen bases, and walks. Even the biggest cases rarely come out of nowhere but are rather forecast through other, smaller decisions. This case represents judicial progress a sharp single into center field and is well worth celebrating.

There are, however, storm clouds on the horizon. Justice Sotomayor wrote a sharply worded dissent (Ruth Bader Ginsburg joined) claiming that the Courts decision profoundly changes the relationship between church and state by holding, for the first time, that the Constitution requires the government to provide public funds directly to a church. But this is overwrought. Again, given existing precedent, the profound change would have been a ruling against the church. The Court would have sanctioned outright anti-religious discrimination in areas as benign as tire-recycling and playground-resurfacing. That would have pushed Establishment Clause jurisprudence back from its trending neutrality to the outright anti-religious hostility of the most far-left judicial activists.

Moreover, the case created consensus in part because it didnt touch on the hot-button cultural conflict between religious freedom and the sexual revolution. Just before the Supreme Court announced its ruling in Trinity Lutheran, it also announced that it would hear a Christian bakers appeal in Masterpiece Cakeshop v. Colorado Civil Rights Commission, a case that could determine whether the state can compel citizens to lend their artistic talents to celebrate events they consider to be immoral. In this case, the question is whether a Christian baker can be required to help celebrate a gay wedding. It would be surprising indeed to see anything other than a 54 decision in that case, with Justice Kennedy likely providing the swing vote.

But thats tomorrow concern. Today was a good day for religious liberty. Seven of nine justices took a hard look at a government program that explicitly discriminated on the basis of religion and rejected it out of hand. Todays message was clear. People of faith arent second-class citizens, and their churches are entitled to equal treatment under the law.

READ MORE: In Trinity Lutheran, One Question Exposed Missouris Historical Hostility to Religion Do Safer Playgrounds Advance Religion? Editorial: TrumpsHalf Measure on Religious Liberty

David French is a senior writer for National Review, a senior fellow at the National Review Institute, and an attorney.

Here is the original post:

The Supreme Court's Religious-Freedom Message: There Are No Second-Class Citizens - National Review