Lonza expands in Asia: 8000L single-use in Singapore, regenerative meds in Japan – BioPharma-Reporter.com

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Lonza will install four 2,000L single-use bioreactorsat its Singapore facilityto cater for growing demand for small to mid-volume biologics production.

At present the Tuas facility houses 86,500L of stainless steel bioreactor capacity including four 20,000L stirred fermenters.Last October Lonza announced it was making an undisclosed investment in single-usetechnology for mammalian manufacturing at the site.

And speaking in Tokyo this week, SVP of global sales Cindy Reiss-Clark revealed more details:

We are adding up to four by 2,000L single-use bioreactors, with the first two being on line in early 2018, she told delegates at the first BioPharma Expo, being held alongside Interphex Japan. This expansion is supporting the commercialisation strategies [of our customers] which require small to mid-scale [bioproduction].

She added one of the first customers to leverage the new technologies in Singapore would be Tracon Pharmaceuticals, a Californian-based oncology-focused firm which entered into a long-term agreement for commercial production of its lead candidate TRC105 in February this year.

Lonza will transfer the process to the 2,000L[line] in Singapore, Reiss-Clark said, while providing ongoing clinical support for the antibody which has orphan drug designation for the treatment of soft tissue sarcoma.

Cell and gene therapy space

She also spoke about Lonzas collaboration with Nikon CeLL innovation part of the Nikon Corporation. The firms are developing a cell and gene manufacturing services business in Japan.

The partnership was first announced in May 2015 and a GMP facility in Tokyois on track and will be ready in 2018, according to Reiss-Clark.

The Singapore site has cell and gene therapy capabilities but this latest project will strengthen Lonzas presence in Asia.

The firm recently acquired European cell and gene therapy maker PharmaCell in a deal that a spokesperson told this publication places Lonza as the leading contract development and manufacturing organisation offering an international cell and gene therapy manufacturing network, spanning the US, Europe and Asia.

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The Futurist Scorecard: A Look At (Almost) Everything That Interests Elon Musk Besides Building Cars – Yahoo News

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Rocket ships, brain chips, music streaming, autonomous driving, solar power, underground roads with elevators it might be easier to list all the stuff that doesnt capture Elon Musks active imagination.

Best known as a car mogul, the founder and CEO of Tesla Inc (NASDAQ: TSLA) has even teased an interest in building an Iron Man suit for the Pentagon, a fitting venture for a tycoon who may have a Tony Stark fixation (or vice versa).

When he isnt battling existing state laws requiring carmakers to have a separate dealer network to sell, he's doing other stuff.

Heres a brief tour through the varying interests (distractions?) that constitute Musks million-dollar musings.

Space

SpaceX succeeded in launching two of its Dragon 9 rockets over a 48-hour stretch last weekend, one to deliver Bulgarias first telecom satellite on Friday and a second on Sunday. The latter was to deliver 10 satellites for Iridium Communications Inc (NASDAQ: IRDM), which is setting up a global positioning system for commercial aircraft.

Delivering satellites and carrying payloads for NASA to the International Space Station are lucrative priorities reusing rockets and capsules is essential to Musks space business model but he has higher aspirations, such as colonizing Mars.

Cyborgs

The stuff of sci-fi, Musks people are working on a neural interface that would allow the brain to directly control a computer and, theoretically, everything a computer controls. The venture even has a name Neuralink, according to the Wall Street Journal. The company, with a target of four years, aims to sell a product for people with brain injuries. It would eventually allow the human brain to connect to cloud storage, turning people into cyborgs with the ability to combat the rise in Artificial Intelligence, brain-for-brain, in a fight for dominance. No, really.

Entertainment

Musk just doesnt want to make autonomous electric cars, Martian colonies and space ships; he wants to get into the media content business, beginning with music.

Recode, quoting music industry sources, said Tesla is in talks with major music labels about licensing a proprietary music service that would be bundled with its automobiles. This report certainly came out of left field, but at this point, the world should have learned not to be surprised by Elon Musk's seemingly limitless entrepreneurial ambitions, Forbes said.

Food

Its not really Elon, but his brother, Kimbal. A year younger, Kimbal Musk, like Elon, worked for a bit on the family farm in Canada. Hes seeking to overhaul the worlds nutritional values and the way the food supply is grown, harvested and distributed. "[My brother] told me it was crazy to get into the food business; I told him it was crazy to get into the space business," Kimbal Musk told CNBC. "It's working out fine."

Health

Its telling that sectors that havent caught Musks attention (as far as we know) are, well, clamoring for it. Some health experts say if Musk wants to colonize the cosmos, hed better get going on diagnostic tools, health sensors and 3D-device printing to deal with specialized health care required for humans in space.

E-Commerce

Right, been there. Musk made his first fortune as co-founder of Paypal Holdings Inc (NASDAQ: PYPL), which revolutionized the way people buy stuff online. Moving on.

Cue The Sun

SolarCity Corporation, which seeks to monetize and reduce costs of companies switching to solar energy. The multi-billion corporation, which was founded by a couple of Musk cousins on the advice of Elon, is now owned by Tesla.

Boring

The Boring Company is looking into boring traffic tunnels underground, where elevators would take multiperson vehicles to traffic-lite thoroughfares and transport people on high-speed sleds. Flying cars also are in the mix.

Related Link: Earth To Elon: Musk Wants To Conquer Music

_______ Image Credit: By Jurvetson - https://www.flickr.com/photos/jurvetson/2944375891/, CC BY 2.0, via Wikimedia Commons

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Dubai’s Autonomous Flying Taxi Service Will Be Ready for Takeoff This Year – Futurism

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In Brief Dubai is set to shake up the taxi and travel sector at the end of the year by introducing an autonomous airborne taxi service that will transport passengers along set routes. Given the growing population, innovative transportation solutions like Dubai's will be an integral part of future society.

As part of Dubais bid to be a city of the future, they plan to have 25 percent of their public transport autonomously controlled by 2030. An exciting aspect of this is the autonomous aerial taxi (AAT) service they announced in February.

Now, theyve provided an updated timeline for the services implementation, announcing that testing will begin toward the end of this year. It will continue for approximately five years until legislation is in place to facilitate a larger expansion.

The goal of the AAT is to eliminate the growing problem of traffic within the city. The service was due to launch at the end of Julywith the single-seater EHang 184, but theplan now it to use the two-seater Volocopter. Implementation has been delayedto ensure the technology is as safe as it possibly can be.

Dubai will be the first city to use air taxis, and its experiment will have a profound effect on the future of transport, as other cities and companies will be judging the applicability of the idea based on Dubais successes or failures. A particularly interested party will be Uber, which is planning to develop an autonomous airborne taxi service of its own.

A key question the transportation industry currently faces is how to deal with the congestion caused by an ever-increasing demand on infrastructure. Although air taxis are one solution, Elon Musk has been boring tunnels under cities, Dubai is developing a hyperloop, and autonomous cars are being programmed specifically to prevent traffic jams.

Whether one of these approaches proves better than the others or we end up using some combination of two or more, well need to be innovative when planning the transportation of the future.

Disclosure: The Dubai Future Foundation works in collaboration with Futurism as a sponsor and does not hold a seat on our editorial board.

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Breaking Discovery: Water Has Two Liquid Phases – Futurism

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In Brief Researchers from Stockholm University have confirmed the existence of water's two liquid forms, one with a low density while the other has a high density. Their insight could help develop better purification and desalination processes. Not One, But Two

Similar to how weve begun to uncover new properties in Hydrogen, the worlds most basic element, scientists are now discovering how complex water really is. Considered to be one of the most fundamental molecules on Earth, water (H2O) may actually have not one, but two distinct liquid phases. The discovery was made by researchers fromStockholm University in Sweden, and the team published their findings in the journal of the Proceedings of the National Academy of Sciences (PNAS).

The new remarkable property is that we find that water can exist as two different liquids at low temperatures where ice crystallization is slow, Stockholm University professor and researcher Anders Nilson said in a press release.

Concretely, they saw that liquid water fluctuates between high andlow density forms. X-rays at the Argonne National Laboratory near Chicago found the difference in structures, while the large X-ray laboratory at DESY, a national research center in Hamburg, confirmed that both forms were indeed liquid phases. We have in particular been able to follow the transformation of the sample at low temperatures between the two phases and demonstrated that there is diffusion as is typical for liquids, Fivos Perakis, apostdoctoral researcher at Stockholm University with a background in ultrafast optical spectroscopy, explained.

Its not surprising, really, for water to have such bizarre properties. For one, it already has many other uniquely strange properties that set it apart from other liquids. The new results give very strong support to a picture where water at room temperature cant decide in which of the two forms it should be, high or low density, which results in local fluctuations between the two, researcher Lars G.M. Pettersson said. In a nutshell: Water is not a complicated liquid, but two simple liquids with a complicated relationship.

On a practical level, this understanding of how water behaves at different temperatures and pressures can help researchers to develop better purification and desalination processes. On an even grander scale, however, it could help us to see how water is affected by the salts and biomolecules necessary for life. The strange properties of water become stranger still as these actually make water a prerequisite for life as we know it.

Assuming the same conditions apply in exoplanets, this could help us spot water and potentially life beyond Earth.

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Wind Energy Has Officially Become Cheaper Than Fossil Fuels – Futurism

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In Brief Industry leaders have estimated that the cost of producing energy using wind farms has dropped to around $100 per megawatt hour, making the energy source as cost effective as coal and nuclear energy. The Plummeting Price of Wind Energy

Bent Christensen, who is responsible for cost projection for Siemenss wind power division, has estimated that Europes offshore wind industry has reached a milestone three to four years ahead of schedule: achieving wind energy at 100 ($113) per megawatt hour (MWh). This means that offshore wind farms could be built without government subsidy because they are economically viable without additional support.

In wind energy, there has been a fast reduction in price over the last three years, falling 27 percent since 2014. According to a Lazard survey in 2016, this means that the energy source has become either cheaper or equal to coal-fired generators, nuclear reactors, and rooftop solar arrays.

Some even predict a further reduction in price estimating that in the future it will be possible to deliver wind energy at 75 ($84) and 62 ($70) MWh. But this hopeful advancement depends on turbine, cable, and converter technology developing much further. Siemens Gamesa and MHI Vestas Offshore Wind plan to have such technology in place in time for the 2024-2025 North Sea projects completion.

Wind powers fall in price marks a major victory for renewable energy because it makes the power source attractive economically as well as environmentally, which is crucial for its widespread adoption. Other promising news that could advance the trend for adopting wind-power is Denmark providing all their power for a day using the source, and the development of record-breaking turbines capable of producing 216,000 kWh of energy in a 24 hour period.

The decreasing price of renewable energy, however, is not just reserved for wind-power: similar victories are also taking place in the solar energy sector. A recent report by Bloomberg has estimated that in four years solar will be cheaper than coal worldwide, having dropped in price by 58 percent within the last five years.

It is unlikely that our world will use less power as populations increase and industry hasto keep up. Therefore, in order to save our planet from pollution and the progression of climate change,we must tinker with the other side of the formula making the energy we use cleaner and greener. Advances in wind and solar power, in particular, are especiallypromising, as they lay the path for renewables creating both individual and collective gain.

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There May Be No Limits to How Long Humans Can Live – Futurism

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In BriefIn 2016 researchers said that there is a limit to the humanlifespan, of about 115 years. Meanwhile, 5 teams of scientists havepublished rebuttals to the 2016 study, and other researcherscontinue to push the aging envelope with new technologies. The Claim And Criticisms

In October 2016, molecular geneticist Jan Vijg published a paper claiming that the human lifespan was limited to 115 years. This kindled a vigorous controversy among scientists, and on June 28 of this year, five groups of scientists published formal rebuttals to the claim.

Vijgs work analyzed demographic data from the 20th century, taken all over the world, and demonstrated that peak age plateaued at about 115 years starting in the mid-1990s. Based on their results, the authors concluded that the natural human age limit is 115 years old and that there is the probability of less than 1 in 10,000 of living to be more than 125 years old.

You could probably guess, not everyone in the scientific community agrees. Most criticisms arise from the way the Vijg team handled their data, and their process for drawing conclusions. First, the Vijg team tested their data to prove whether or not the plateau they felt they observed after 1995 was in fact present. In other words, they generated a hypothesis and then tested it using the same dataset, which is typically unacceptable, as it causes inaccurate results due to severe overfitting, a fit based on error or noise, not a real relationship.

Second, the teams actual data set was very small because in each year they counted only the oldest person who died. They then subjected this inordinately small sample to standard linear regression techniques, which was not appropriate based both on the small sample size, and the additional fact that the individuals being counted were outliers who should have been subject to extreme event analysis. In fact, the decline suggested in the 2016 conclusions appears to be suggested by a single death in the data set.

Moreover, other scientists reanalyzed the data and found it consistent with multiple lifespan trajectories, not just the one reported in 2016. Finally, several scientists in their rebuttals point to the overall body of work on the biology of aging over the past few decades which suggests that the human lifespan has been far more flexible than previously believed; which alone indicates that the proposed limit should be viewed with extreme caution.

The authors of the original study stand by their work and disagree with the criticisms of the statistical methods used. Vijg also believes that the real cause of the outcry is not the data, which is convincing, but the fact that aging cant be stopped and there is a limit to human life: I guess the main message is that a lot of people have difficulty accepting that everything now points toward an end in the increase of maximum lifespan, Vijg told The Scientist.

University of Illinois at Chicago professor of public health Jay Olshansky, who was involved in neither the original study nor the rebuttals, thinks the criticizing scientists are missing the real point of the 2016 study, which he clarified for The Scientist: The most important message to get across, in my view, is that we should not be trying to make ourselves live longer, we should only be trying to extend the period of healthy life.

However, there are many others pushing the limits of human longevity right now who disagree strongly enough to put their money where their philosophy is. Since research has demonstrated that transfusions of younger blood, or parabiosis, was able to rehabilitate cognitive abilities in mice, a startup called Ambrosia has started to offer a human clinical trial of parabiosis for paying clients. Peter Diamandis of the genotype research facility, Human Longevity, Inc., is searching for the key to using nanomachines or stem cells to regenerate our bodies. And Metformin, which has been shown to prevent cancer and extend life in animals, began clinical testing as an anti-aging drug in February.

There are so many possibilities in motion that it does seem hard to agree with a firm limit to the human lifespan. In the end, time will resolve the controversy once and for all. Ironically, well only be here to see it if the critics are right.

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Your Next Flu Shot Could Be Delivered Using an Injectionless Patch – Futurism

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In Brief These positive results from a small clinical trial may mean you will have a new way to get your next flu vaccine. Instead of an actual injection, researchers from Georgia Teach and Emory University have developed a sticker patch that comes with microneedles that you can just stick on your skin. No Fear of Injections

We all have that friend who avoids getting flu shots out of fear of injections, right? Well, researchers from Georgia Institute of Technology and the Emory University had you we mean, your friendin mind while designing this new way todeliver vaccinations. Instead of the usual injection, the researchers came up with a sticker patchthat you can applyon yourself.

The patch comes with a hundred tiny hair-like microneedles located on its adhesive side. If you zoom in under the microscope what youll see are microscopically small needles, lead researcher Mark Prausnitz told the BBC. They puncture painlessly into the skin. Unlike regular injections that go all the way through the muscle, the microneedles puncture and dissolve into the upper layer of the skin, delivering the vaccine in about 20 minutes.

A small preliminary clinical trial was recently published in The Lancetthatinvolving 100 volunteers and showed that applying the patch was relatively painless compared to a regular flu shot. A few people got some mild side-effects, like redness and irritation on the skin where the patch was applied. These disappeared after a couple of days. Initial findings also revealed that the patch vaccines successfully immunized the users against the flu.

The FDA will require larger human studies before it definitively determines that the vaccine patch is safe and effective, but such a technology is truly revolutionary. As soon as this patch system gets approval for widespread use in the next couple of years, getting flu shots or other vaccines would be as easy as putting a Band-Aid. We could envisage vaccination at home, in the workplace or even via mail distribution, said Emorys Nadine Rouphael,speaking to the BBC.

Plus, you can do it yourself. With the microneedle patch, you could pick it up at the store and take it home, put it on your skin for a few minutes, peel it off and dispose of it safely, because the microneedles have dissolved away,Prausnitz said in a press release.

This also opens up a better transport and delivery system for vaccines to reach remote areas. The patches can also be stored outside the refrigerator, so you could even mail them to people, Prausnitz added in the press release. Hes already working witha company that wants to license this technology.

As John Edmunds from the London School of Hygiene & Tropical Medicine, who wasnt involved in the study, told the BBC, This study is undoubtedly an important step towards a better way to deliver future vaccines.

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MIT Professor Gives A Dire Warning to the US About Funding Science – Futurism

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In Brief In a video shared by Bill Gates, Broad Institute director Eric Lander warns that the decline of support for private and public research sectors could lead to the U.S. falling behind as a global leader in research and innovation. The Miracle Machine

They say theres no alternative to hard work, butmost researchers probably wouldnt turn down the opportunity for more collaborative research thatswell-funded.Thats the philosophy behindwhat theBroad Instituteat MIT calls the Miracle Machine. The Miracle Machineproduces amazing advances in science and technology as a result of federal support an funding forthe public and private sectorsof the research community. However, as a video narrated by Broad Institute director Eric Lander explains, one of Americas greatest assets is falling into disrepair.

Microsoft founder and billionaire philanthropist Bill Gates retweeted Landers post that linked to the video, echoing some of its major points. One of which is that research can do wonders for the economy, health, energy, and defense of the United States or any nation for that matter.

Unfortunately, federal support for research has been dwindling. Over the past decade, funding for a number of research institutions has been on the decline, including the National Institutes of Health (NIH) which has lost 25 percent of its budget over the past 13 years. The most recent budget proposed by the U.S. Congresswouldnt do much to improve those number, either.

In the same way that this private and public sector partnership pushed basic scientific research forward, much to the benefit of many sectors in the U.S., the decline in federal support will have a ripple effect across several industries. We may wake up to find the next generation of technologies, and industries [] are being produced elsewhere, Lander points out in the video. With Europe, China, Dubai, and other nations investing more in scientific research rather than less, it isnt a stretch to think that the U.S. could fall behind.

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A New Company Will Have Fake Meat on the Shelves Next Year – Futurism

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In Brief Hampton Creek has surprised the world by announcing they have been working on lab-grown meat and plan to launch commercially in 2018. This meat alternative is one of many possible solutions to the environmental problems caused by the food industry. Meaty Ambitions

Hampton Creek, a startup that develops plant-based alternatives to foods that are usually produced by animals, has announced that the lab-grown meatthey have been developing clandestinely over the last year will go commercial in 2018. If the timeline is accurate, the launch would come three years earlier than their closest competitor, Memphis Meats, which predicts their product will reach stores in 2021.

One of the biggest issues Hampton Creek will face in achieving this aim is the cost of clean meat. Although the price of lab-grown meat has fallen 99 percent in the last three years with the first lab-grown burger costing $230,000 it is still more expensive than farmed meat. Hampton Creek has not released any information concerning how much their product will cost.

Central to the companys product istheir research into replacing the scarce fetal bovine serum that most lab-grown meats use with plant-based nutrients. Simply getting that right wont be enough to produce a solid final product, though. As Josh Tetrick, CEO of Hampton Creek, conceded to Quartz, Just because youve nailed the battery doesnt mean youve nailed the electric car.

Opinion is split as to whether the 2018 goal is achievable. Some cite Hampton Creeks previous actionswhen they were developing and marketing their Just Mayo product as a reason to be skeptical. Others are more optimistic regarding Hampton Creeks timeline the Good Food Institutes executive director Bruce Friedlichtold Business Insider that with the right resources, it should be achievable.

A cost-effective, price-competitive clean meat could have paradigm-shifting consequencesfor both the world food market and the environment. Not only would it radically reduce animal suffering, it would also decrease global emissions. The meat industry is estimated by the World Resources Institute to produce 13.5 percent of greenhouse gases worldwide, and if nothing changes, this percentage is likely to increase given that the worlds population could reach around 9.7 billion by 2050.

To combat these issues, the world has seen a surge in the production of alternative meat products, which can be split into three categories: plant-based meat, such as the pea protein-based pea burger produced by Beyond Meat; more sustainable meat sources, such as the insect meat produced by Cornish Edible Insects; and lab-grown meat, such as that proposed by Hampton Creek and Memphis Meats.

If we are to survive as a species, we must radically change how much pollution we create, and changing the way we eat is a key aspect of this. Any alternative to the environmentally damaging meat industry represents a step toward preserving humanitys future, so let us all hope Hampton Creeks announcement is as promising as it seems.

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There’s A New Way to Use Meditation to Reshape Your Brain – Futurism

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Futurism only supports companiesthat we trust. Aura Premiumis one of those companies. We may collect a share of the sales from the items featured on this page. Sign up for Aura Premium here. A New Way to Think

Mindful meditation is becoming an increasingly popular tool, one that people use to manage both their emotional and mental health. The practice is,in essence, the art of not reactingthe art of finding inner stillness through the use of external stillness. Its taking the time to close your eyes, turn your focus inward, and put all of your energy into just breathing.

Its an incredibly simple practice that doesnt take much time at all, and it is incredibly helpful. Ina study published in Clinical Psychology Review,researchers at Boston University and Harvard Medical School found that the technique helps alleviateanxiety and allows individuals to better cope with stressfulsituations. Similarly, in a study fromFrontiers in Psychology, researchers found that individuals who meditate have more gray matter volume in their brains than those that do not.

Yet, only 18 million Americans report their participation. Unfortunately, the reality for many overworked Americans is that relaxation is a luxury. Indeed, 92 % of the country still hasnt caught onto the trend. Its a surprising statistic considering the fact that meditation has been proven to increase concentration, decrease anxiety, and even help to preserve the aging brain.

Over the last few years, there have been a variety of apps that have aimed to close the gap between people who make time for meditation and the people who dont know how to fit it into their lives. And while many of the apps that have hit the market have effective qualities, few are as impressive and progressive asAura Premiumthe app created by meditation teachers and therapists that actually gets to know you, so it can help you better.

The AI-infused app is programmed to take post-session feedback information and use it to become a dynamic tool that assists with your mental health. Each time you use the app, it creates more pathways for you to get better at finding your zen.

And while anyone whos into mindful meditation will appreciate the app for its relaxation enhancers, its most appealing for people who are new to meditation and need guidance. All users need is three minutes a day to practice, though you can also choose 7 and 10-minute meditation durations as well.

The app is mostly geared towards helping its users get into a better headspace through exercises, breathing routines, and key spoken wordsthough it also has the ability to track users moods to help them see patterns and form connections.

Aura is essentially like having a portable guide in your pocket. And its been so successful in helping its users find inner peace, it was rated the best new app for February 2017 with thousands of nearly perfect ratings. For $59.99 on StackSocial, you can get a lifetime subscription to the app and start your journeyto better mental health.

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A State of Freedom by Neel Mukherjee review vital meditations on migration – The Guardian

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Repeated words, pronouns not clearly referring to one character or another, flabbily padded phrases, irritating tics of style (the use of the word all as in all longish hair), eruptions of verbosity (the indescribable sound that emanated from that swiftly engorging clot of people): there is so much distractingly bad writing in the first section of Neel Mukherjees new novel, its difficult to concentrate on what he is actually saying. As far as the plot goes, it seems to be something at once melodramatic and not all that surprising. An Indian father born in Calcutta but now working in the US takes his six-year-old son, who has been raised in America, to see the Taj Mahal and the nearby monuments at Fatehpur Sikri. Here, thanks to a bit offunny business with shadows and guides (Marabar Caves, anyone?), the son freaks out, and the father is forced to accept that he has become a tourist in his own country.

Its not a good start, from a writer who has already been shortlisted for the Booker and the Costa and won the Encore prize for his second novel, The Lives of Others. But anyone tempted to abandon the book at this point should persevere. Although later pages are still liable to congestion and carelessness, they are much better written. Theyre also ambitiously and intelligently engaged with important themes several of which are treated explicitly (deracination, the inequalities of Indian society), and one of which emerges more subtly, through clever and well-handled plotting.

At first glance the narratives of the five sections seem discrete, although all tending towards similar interests and conclusions. As scene follows scene, however, Mukherjee returns tocharacters and events that have previously appeared only in the background of each story, to flesh out their details. So, for instance, a horrible accident involving a construction worker who falls from the scaffolding of a new building, witnessed in passing by the father and son in the first section, links both to a later section in which we hear the story of the victims earlier life, and to the final section in which we read the unpunctuated monologue spoken immediately before his death. In the same way, a poverty-stricken man leading a dancing bear, who appears briefly beside the car window as the father and son return toDelhi, turns out to be the brother of the construction worker, and later gets most ofa whole section to himself. We hear about his family and their hardships, about the training of the bear, about their time on the road together, and about the ways in which their relationship allows and simultaneously denies a state of freedom.

This linked structure emphasises the value of life as life, regardless of wealth and status and circumstance. But it also conveys a sense of inter-relatedness that allows Mukherjee to say something about how families and communities work in general, and about how Indian society functions in particular. His sharpest focus is on the way life carries characters like dice on the slot of a roulette machine and delivers [them] to destinations that [are] endlessly repeatable, each ever so slightly different from the other, all more or less the same. In this respect A State of Freedom touches on distinctly English-Victorian themes. And like the intricately woven novels of say Dickens, it has its foundation in the denunciation of injustice, and the valuing of compassion.

In the second section, for instance, ason raised in India but now working in London stays with his parents in Mumbai, and becomes interested intheir cook, Renu, and another servant named Milly. As far as the parents are concerned, the significance of these two consists largely in how well or badly they do their work. But the son more liberal, more curious, and like several other characters in the book, very interested in food and its preparation inquires into their lives, and is eventually encouraged by Renu to visit her home village. When he does so, he receives a lesson in social awkwardness, and in the limits of his own capacity to imagine the lives of others, which picks up themes that are announced in Mukherjees opening pages.

The sound of grief is audible everywhere, but it never drowns out the voices insisting on their right to thrive

Much the same goes for the fourth section, in which were given the backstory of Milly, the other servant. Originally named Manglu and the daughter of a drunken father, she was raised in great poverty. She seeks to improve her lot by taking work as a servant away from her village: during her travels and travails, which Mukherjee describes with an impressive sense of actuality, she experiences various degrees of tolerance and intolerance, culminating in a life of more or less complete captivity from which she is eventually rescued.

Millys childhood friend Soni, meanwhile, stays behind in the village and joins the local Maoist guerrillas, living in the woods and enduring her own form of hardship. When Milly hears news of her, her response contains questions that unite the two strands of the narrative, and resonate throughout the novel. What are the costs of leaving and staying at home? What are the limits of human resilience? Or as Milly herself says: How can movement from one place to another break you? Are you a terracotta doll, easily broken in transit?

At a time when the manifold dramas of migration are centre stage, we often hear writers making the sound of lamentation. The sound of grief is audible everywhere in A Sense of Freedom, but itnever drowns out the voices insisting on their right to thrive. One of the most dynamic aspects of Mukherjees flawed but vital novel isthat even while facing up to unhappiness it continues toshow an affirming flame.

Andrew Motions Silver: Return to Treasure Island is published by Vintage. A State of Freedom is published by Chatto. To order a copy for 12.74 (RRP 16.99) go to bookshop.theguardian.com or call 0330 333 6846. Free UK p&p over 10, online orders only. Phone orders min p&p of 1.99.

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Freedom awards recognize community activists and leaders – Daily Herald

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Gabe Adams was born in a Brazilian hospital more than 20 years ago without any limbs. Adam Paul Steed exposed inhumane treatment of political prisoners being held captive in Syria, saving hundreds of lives. Taj Khyber Rowland provides education and income opportunities in impoverished nations. And Raymond Beckham has chaired countless boards and projects to beautify and develop Utah Valley.

These four have done more than many may do in a lifetime. For their contribution to the liberty and well-being of others, they were honored Thursday night at the 32nd annual Freedom Awards Gala held at the Utah Valley Convention Center.

Freedoms messy. It is so messy, said Steed, one of the award recipients. Is it worth it? Yeah. Its always worth it.

The Freedom Awards are a part of the annual Americas Freedom Festival Provos city celebration that includes the Stadium of Fire, Balloon Fest and Grand Parade.

Past recipients of the award include Timothy Ballard, CEO of Operation Underground Railroad; Gail Halvorsen, the legendary Candy Bomber; and the late Boyd K. Packer, once president of the Quorum of the Twelve Apostles of The Church of Jesus Christ of Latter-day Saints.

Dancing usually involves a lot of footwork, some twirling and the occasional cha-cha-cha. But not so for Adams.

Adams was born in Brazil without limbs. But rather than lay around, mope and feel pitied, he worked hard and overcame his obstacles to be on his high school cheerleading team at Davis High School.

Adams has a unique zest for life and hopes to spread his cheerful disposition to others through motivational speaking.

Someone once said, Dont let what you cant do interfere with what you can, he said.

Adams has become independent in his own sense and enjoys personal freedom by overcoming what couldve been a negative aspect of his life.

I love the kind and generous people who I love and who have blessed my life in too many ways to count, more than I have on my fingers, he said jokingly.

Rowlands childhood was far from ordinary. When he was a boy, Rowland was born into poverty and struggled to keep himself and others of his family even alive.

I have early memories of scrounging through restaurant garbage for little bits of food, just trying to stay fed, Rowland said.

At a young age, Rowland was kidnapped and sold to a Christian orphanage in India. He was then adopted by Fred and Linda Rowland of Orem.

The Rowlands had no idea their new son wasnt an orphan. They worked tirelessly to find Rowlands childhood home, but to no avail.

For years, he searched for his forgotten home, remembering as many small facts of geography and unique landmarks as he could, going so far as to draw a map of what he could remember.

Years later, he and his wife, Priya, returned to India and he found the village of his childhood.

Rowland felt inspired from his reconnection with his biological family and after understanding more of the lives of impoverished communities, he and his wife founded Taprish, a nonprofit that provides educational and income opportunities to low-income communities across the world.

Freedom, to me, is probably the greatest gift Ive been given through adoption, he said. It allowed me to live a life that, otherwise, I would not have had.

If you take Beckham out of Provo, youre not left with really a lot.

Beckham has been on the boards of countless projects and councils for Utah Valley and particularly Provo. Beckham was directly involved in the building of LaVell Edwards Stadium, the Marriott Center, the BYU Museum of Art and the Provo Recreation Center, not to mention restorative projects in downtown Provo and the citys parks.

If you want to be happy, serve others, he said. I think all of us want to help the poor, to give comfort to those who are troubled. But its not enough to just want to. You have to do it.

Beckhams years of countless service and dedication to his community are an example of what he hopes to see in others.

May we always be searching for ways to serve others to take care of our communities and to volunteer, Beckham said.

Steed has provided the gift of freedom to the lives of hundreds by working hand in hand with Syrian refugees.

In September 2015, Steed, who was working at the time in Greece with Syrian refugees, learned of hundreds of political prisoners leading a revolt in a Syrian prison. He received video from the inside of the prison and published it through the European media. Steed said he knew that if Bashar al-Assad saw the unedited, raw videos, Assad would release the prisoners so as to not damage his public reputation.

This strange group of people came to them from the palace in Damascus and instead of killing these people, they came into them and were like, Hey, were your friends. Heres food and water, Steed said.

And just like that, hundreds of lives were saved from unknown fates.

But Steed isnt the only one who can save lives. He urged all in attendance to make a difference and fight for those who only want a piece of the freedoms enjoyed in America.

If I can say anything thats truly beyond measure, its that you can save these people, Steed said. You can do better than me, if that, and more.

Americas Freedom Festival continues through the weekend until July 4. A list of events can be found in our special section devoted to the festival.

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Freedom awards recognize community activists and leaders - Daily Herald

‘Wings of Freedom Tour’ to bring vintage aircraft to Missoula – The Missoulian

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Four vintage WWII aircraft will fly into Missoula for a three-day visit next week as part of the Collings Foundations Wings of Freedom Tour.

The national tour pays tribute to those who flew, built, maintained and benefited from the aircraft during and after the war, and gives the public an opportunity to either tour the aircraft on the ground, or go for a ride over Missoula.

The Wings of Freedom Tour is a living history event that allows people to learn more about their heritage and history through direct participation, according to a news release.

The four aircraft visiting Missoula include a Boeing B-17 Flying Fortress heavy bomber, a B-24 Liberator heavy bomber, a North American B-25 Mitchell, and a P-51 Mustang fighter. They will be on display at the Museum of Mountain Flying at Missoula International Airport.

According to Stan Cohen, co-founder of the Museum of Mountain Flying, the P-51 Mustang fighter has never been brought to Missoula before, and it is the gem of WWII airplanes.

Flights on the B-17 or the B-24 cost $450 per person, B-25 flights costs $400 per person, and P-51 flights cost $2,200 for a half-hour and $3,200 for a full hour. To explore the aircraft on the ground, adults pay $15 and children younger than 12 pay $5.

The Wings of Freedom Tour will be on display for ground tours from 2 to 5 p.m. on Wednesday, July 5; from 9 a.m. to 5 p.m. on Thursday, July 6; and 9 a.m. to noon on Friday, July 7. Thirty minute flights are usually scheduled before or after these times.

For reservations or information, contact the Collings Foundation at 800-568-8924.

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'Wings of Freedom Tour' to bring vintage aircraft to Missoula - The Missoulian

LA Freedom Festival celebrates Fourth of July with symbolic new … – LA Daily News

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When: 5:30 to 10 p.m. Tuesday, July 4

Where: Santa Monica Boulevard and Avenue of the Stars, Los Angeles

Admission: Free

Information: https://farhang.org.

While people gather at the inaugural L.A. Freedom Festival for a night of Persian pop, ethnic food, and Fourth of July fireworks, a new public artwork will be unveiled.

Dubbed The Freedom Sculpture, the stainless steel monument by internationally renowned Sri Lankan designer Cecil Balmond and modeled on the progressive Cyrus Cylinder of ancient Persia is a gift to the city. And like the original Cylinder, its a symbol of religious freedom, cultural diversity and inclusiveness.

Heres a message that has come down 2,500 years and landed itself on a busy thoroughfare in Los Angeles where people are going to pass it by the millions, says Balmond, speaking by phone from his home in London. Its like the message keeps on traveling.

That early declaration of human rights is represented in the large-scale contemporary artwork by a metallic gold cylinder within a silver cylinder and supported by two rings that ground it to the public transit median on historic Route 66, on Santa Monica Boulevard at Century Park East. It appears lacelike, echoing the original cuneiform script from a distance.

In the day, it shines silvery with glints of gold, and by night the golden inner cylinder is illuminated by LED lights.

To build form, you have to have a poetic sense of space, he says. I like to think that my work reflects that. Of course its subjective how you decide the visitor should see and engage with your work. If you see my artworks, go to my buildings or cross my bridges, youll see theyre never static.

The Freedom Sculpture began as an idea by the Farhang Foundation in late 2013. In 2014, it launched an art competition that attracted more than 300 submissions from around the world. The panel of jurors, which included curators from the Los Angeles County Museum of Art, chose the winning design in late 2015.

Balmond is known for his large public displays.

They include the award-winning Snow Words, an abstract tower of light suspended between a skylight and a mirrored floor in the lobby of the Crime Detection Laboratory in Anchorage, Alaska, to commemorate fallen officers in 2012.

In the current divided political climate, the public artwork takes on greater meaning.

Angelenos, who comprise millions of people from different ethnicities, religions and lifestyles living together in peaceful harmony, are an embodiment of these noblest of American ideals, says Farhad Mohit, vice chairman of the Farhang Foundation, which commissioned Balmond to create the work as a gift to the city. For them, the Freedom Sculpture will become an iconic symbol of another of the unique attributes of this great city.

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LA Freedom Festival celebrates Fourth of July with symbolic new ... - LA Daily News

Freedom sweep the Rascals at UC Health Stadium; hit the road until after the All star break – User-generated content (press release) (registration)

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Jose Brizuela belted a two-run homer in the eighth inning to propel the Florence Freedom, presented by Titan Mechanical Solutions, to their sixth series sweep of the season as they topped the River City Rascals, 5-3, on Thursdayat UC Health Stadium.

Following a dropped third strike that allowed Taylor Oldham to reach first base with two outs in the bottom of the eighth inning, River City (20-23) skipper Steve Brook made his second pitching change of the night, replacing reliever Jason Zgardowski (1-3) with southpaw Anthony Paesano to face Brizuela.Despite promptly falling behind 0-2, Brizuela fouled off six pitches and worked the count full before ending the twelve-pitch at-bat with a line-drive home run to right-center, putting Florence (30-12) in front by the eventual final score, 5-3.

A Jeff Kerrigan RBI-single off Freedom starter Zach Kirby in the second inning and a solo shot by Josh Silver put River City on top 2-0 entering the bottom of the fifth, where Rascals starter Tim Koons carried a perfect game. Leading off the home half of the fifth, however, Andre Mercurio broke up the perfect game with a single to right field and later came around to score on a bases-loaded walk by Ryan Rinsky, making the score 2-1.

The Freedom would tie it in the bottom of the sixth with Oldham launching his second home run of the series to knot the score at two.

In the bottom of the seventh, Florence took their first lead of the night by a score of 3-2, thanks to a go-ahead solo home run to left field by Collins Cuthrell. River City promptly tied it back up in the top of the eighth, however, when a Kerrigan single and stolen base led to an RBI-single by Josh Silver off Freedom reliever Keivan Berges (1-0).

Following the eighth-inning go-ahead blast by Brizuela, Enrique Zamora pitched a flawless ninth inning to end the night.

The Freedom will hit the road for a brief two-day road trip to Evansville, Indiana for a three-game series against the Evansville Otters. Tony Vocca (5-2) will start for Florence against Evansville right-hander Diego Ibarra (1-1), and first pitch is scheduled for 6:35 p.m. Central Time at Bosse Field.

The Florence Freedom are members of the independent Frontier League and play all home games at UC Health Stadium located at 7950 Freedom Way in Florence, KY.The Freedom can be found online at FlorenceFreedom.com, or by phone at 859-594-4487.

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Freedom sweep the Rascals at UC Health Stadium; hit the road until after the All star break - User-generated content (press release) (registration)

Pott. County Freedom Rock dedication Tuesday – The Daily Nonpareil

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The Pottawattamie County Freedom Rock will be dedicated on the day that officially celebrates Americas freedoms.

The ceremony will be held at 3 p.m. Tuesday at Chautauqua Park in Oakland.

The rock is part of a statewide program to place a patriotic rock in each Iowa county. The program was started by artist Ray Bubba Sorensen II of Greenfield, and the original Freedom Rock was placed there. He has now completed 59 Freedom Rocks in Iowa, including those in Cass, Fremont, Mills, Page and Shelby counties, according to a press release from the Oakland Friday Coffee Ladies, who spearheaded efforts to have a Freedom Rock placed in Oakland.

The 82-ton rock was moved from Schildberg Rock Quarry near Macedonia to its new home in Oakland on April 13, 2015, by Scribs Moving and Heavy Hauling of David City, Nebraska. Because of Sorensens schedule, he wasnt able to start painting it until March 8, 2017. He finished painting in 10 days.

The rock which measures 13 feet long, 10 feet wide and 10 feet tall features a huge American flag on top with a bald eagle on one side, the press release stated. The other side features portraits of four deceased veterans with ties to Pottawattamie County:

Frank F. Everest, born in Council Bluffs, served as commander of U.S. Air Forces in Europe and commander of the Tactical Air Command. He attained the rank of general.

Arnold W. Jacobsen, born in Walnut, served as commanding officer of the Marine Corps Supply Depots during World War II. He attained the rank of major general.

John S. McCain Jr., born in Council Bluffs, served in conflicts from the 1940s through the 1970s, including as the commander of the U.S. Pacific Command. He achieved the rank of admiral in the Navy. McCain was the father of Sen. John McCain of Arizona.

Brent Maher of Honey Creek served as a sergeant with the Iowa Army National Guard. He was deployed to Afghanistan on Aug. 1, 2010 and was killed by an improvised explosive device on April 11, 2011 in eastern Afghanistan.

Chautauqua Park is located at 308 U.S. Highway 6 in Oakland.

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Pott. County Freedom Rock dedication Tuesday - The Daily Nonpareil

Melaleuca Freedom Celebration named one of the top must-see fireworks displays in America – East Idaho News

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Idaho Falls 0Updated at 10:21 am, June 29th, 2017 By: Nate Eaton, EastIdahoNews.com We Matched

The American Pyrotechnics Association named the Melaleuca Freedom Celebration as one of the top five must-see fireworks displays in the country. | File photo

IDAHO FALLS The American Pyrotechnics Association (APA) has named the Melaleuca Freedom Celebration as one of the top five must-see Independence Day fireworks displays in America.

The list, released Wednesday, includes recommendations for the most avid of fireworks fans to consider this 4th of July. The Melaleuca Freedom Celebration is the only display in the western United States to make the list.

CLICK HERE TO SEE THE LIST OF THE APA MUST-SEE INDEPENDENCE DAY FIREWORKS DISPLAYS

Every year were looking for something new and different that is spectacular and draws a large crowd of spectators, said Julie Heckman, executive director of the American Pyrotechnics Association. The size of the Melaleuca Freedom Celebration and the location really jumped out to us. Its one of those shows thats worth making the jaunt to see.

The APA estimates more than 16,000 fireworks displays will commemorate Americas 241st birthday nationwide next Tuesday. The Melaleuca Freedom Celebration, being held at Snake River Landing for the first time, is expected to draw more than 100,000 spectators from all over the world.

The fact that the show is going to be enhanced this year makes it extra special, Heckman said.

RELATED | MELALEUCA PROMISES BIGGEST FIREWORKS SHOW EVER: YOU HAVENT SEEN ANYTHING LIKE THIS

Twenty thousand firework shells totaling 17,000 pounds of explosives will be shot into the air during the Melaleuca Freedom Celebration, according to Melaleuca CEO Frank VanderSloot.

This year were more than doubling the size of the show, VanderSloot said. The fireworks used to be brought in on one 40-foot trailer. This year two 53-foot trucks are needed to bring them all in. Its an enormous amount of firepower.

WATCH: MELALEUCA CEO FRANK VANDERSLOOT DESCRIBES THE MASSIVE FIREWORKS DISPLAY

The 31 minute production is being produced by Western Display Fireworks. The same firing system used during the Winter Olympics will shoot off the explosives synchronized to 1/100th of a second to match patriotic music.

Were bringing in a special pyrotechnician from Frankfurt, Germany to shoot this off, VanderSloot said. He does fireworks competitions all over the world and is the best and the biggest.

The fireworks will be placed on a launchpad 40 times larger than previous years. The platform is one and a half times the length of a football field and the space will be utilized to accommodate the massive number of shells.

Its like going from a 10 inch screen to a 100 inch screen in your living room, VanderSloot said. Were going to paint the entire sky the lower section, the middle section and, for the first time, the higher section. Youre not going to want to miss this show.

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Melaleuca Freedom Celebration named one of the top must-see fireworks displays in America - East Idaho News

PepsiCo got the ecosystem together for GST – Economic Times

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By D Shivakumar

At PepsiCo, there was a task force which was set up. We trained 16,000 people. We have got the entire ecosystem together, done courses, training programmes, clearing of invoices and bills. Its not a small exercise. This task force worked with consultants, with the government. Once the tax rates came, we calculated what happens to us, what happens to industry, what goes up or down, because in different states it could be different. We are fully prepared on what we needed to do, spoke to all ecosystem partners modern trade partners who have their own set of challenges, bottlers whom we need to work with, distributors so that everyone is aware of what they are doing and the other way round. We have worked as closely as possible with all people concerned and resolved issues as early as possible.

ON CHALLENGES The FMCG industry is 9.9 million retail outlets. So educating everybody in the ecosystem, getting wholesalers to keep track of their bills and inventory is a huge change that needs to happen, and its not a change one company can do. But as a consortium, companies can do that. How do you digitise the whole FMCG channel is something that is of paramount importance to the entire industry after GST. The need is even higher after GST.

ON TRANSITION OR UNSOLD STOCKS Weve cut down dramatically on stocks. While every company has cut down, we have cut down even more. Our distributors operate on very thin stocks. Our big distributors are operating with three-day stocks, thats it. So in our case the pipeline is very thin; that is the advantage that will accrue. We can top up very quickly, so we don't have the challenge of unsold stocks, or transition stocks both in case of snacks and beverages.

(D Shivakumar is Chairman, PepsiCo India)

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PepsiCo got the ecosystem together for GST - Economic Times

Mission (To Be) Accomplished: Building Houston’s Innovation Ecosystem – Xconomy

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HoustonHouston has all the ingredients to be an economic powerhouse, but the city wont be able to become oneunless civic and business leaders support the citys fledgling tech community.

That finding, and other recommendations on how to support an innovation strategy for the city, were presented today to the Houston City Council task force members who were last year asked to uncover ways to boost Houstons tech scene.

Houstons lack of a robust innovation and entrepreneurship ecosystem is a significant threat to our economy as it is the largest driver of job creation, as well as a critical component in attracting corporate investment, venture capital, and talent, the report concludes.

Right now, Houstons innovation benchmarks are weak, the report says: Among the top 10 most populous U.S. cities, it is the only one that doesnt rank in the top 20 cities in the nation with the highest density of startups, according to the Kauffman Foundation. The National Venture Capital Association ranks Houston 31st for VC investment.

The Houston Technology & Innovation Task Force began meeting last fall, touring local innovation assets such as NASA, while also visiting other cities to learn how those communities fostered high-growth entrepreneurship.

The group singled out Chicago as a peer city that has, in the last five years, created a vibrant innovation cluster anchored by 1871, a technology center thats home to startups, investors, large tech companies, and other related entities.

Among the recommendations outlined include: Encouraging city leaders to become active advocates of the innovation ecosystem; encourage corporate leaders to get more involved with startup programs, including supporting a fund-of-funds to invest in young companies; and seek out technology tools that would help the city run better. Seek out tax and public policy tools that would help Houston to create an innovation district that encourages the development of startups and makes them part of a vibrant city economy. Supportefforts to make Houston a testing ground for new technologies, especially those such as drones and autonomous vehicles.

This was really for the education of the council, task force chairman John Reale, the co-founder and CEO of Station Houston, says of todays meeting. We heard a lot from them saying, I didnt know this; I didnt know that. Thats been our goal to share with them information on the path forward.

For Yael Hochberg, a Rice University entrepreneurship professor and a task force member, a key feature of this report is not only to recommend that Houston have an innovation district but to also advise on where to place it. In other words, the decision should not be driven by a desire to revitalize a struggling area.

City leaders must locate it in a desirable neighborhood that already has infrastructure: restaurants and cafes, places where young people want to live, areas where people with money are willing to set up offices, she says. If a woman doesnt feel safe walking to her car at 2 in the morning, its not going to work.

Other members of the task force include: Mercury Fund partner Aziz Gilani, Texas Medical Center CEO Bill McKeon, Houston Technology Center CEO Lori Vetters, and civic tech leader Jeff Reichman.

The task forces efforts coincide with one by the Greater Houston Partnership, which has put together its own tech and innovation roundtable to look at how Houstons private sector can boost innovation. In a report the partnership put together with Accenture, the GHP came to similar conclusions about the weaknesses and opportunities in Houstons innovation community.

Houston Mayor Sylvester Turner was not available for comment. Earlier this month, he led a group of civic and business leaders on a trip to Israel where the group visited with that countrys tech entrepreneurs. Gaurav Khandelwal, CEO of app company Chai One, says he was impressed with the level of investment Israel has committed to building its startup community as well as creating a regulatory environment that promotes innovation.

One lesson Houston can learn from Chicago is the sort of fantastical change that can occur when various parts of an innovation community are brought together, Hochberg says. There needs to be these spontaneous collisions that ecosystems need to thrive, she adds.

Angela Shah is the editor of Xconomy Texas. She can be reached at ashah@xconomy.com or (214) 793-5763.

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Mission (To Be) Accomplished: Building Houston's Innovation Ecosystem - Xconomy

Create an ecosystem for design thinking: Anil Kakodkar – The Hindu

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The Hindu
Create an ecosystem for design thinking: Anil Kakodkar
The Hindu
Anil Kakodkar, President National Academy of Sciences, has called upon the educational institutes to create an ecosystem where students can think of best collaborative designing which are key for products. Addressing the two-day 'Industrial Design ...

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Create an ecosystem for design thinking: Anil Kakodkar - The Hindu