Toronto harbor islands hurt by Lake Ontario flooding – WXXI News

Flooding along Lake Ontario is still causing problems in Toronto, the biggest city in Canada, particularly for the picturesque harbor islands.

Julian Ganton owns Toronto Islands SUP, which stands for stand up paddleboard. He looks like a typicalwater sports guy in flip flops, board shorts, and sunglasses.

Normally, this time of year, Ganton would be giving tours or lessons, but instead, he is filling his time by paddling with his friends. Were gonna go check out some of the flooded areas of the island, and just take a tour through some of the lagoons, he says.

The Toronto Islands are a huge pull for tourists. They are just a short ferry from downtown Toronto, with beachy cottages, boardwalks and bicycles there are virtually no cars on the island.

But right now, theres almost no one there. Restaurants and other businesses are suffering.

Undeterred, Ganton sees the opportunity for a new marketing strategy.

"It's been slower, of course," he says, "but we do feature in showing people the natural phenomenon and what it means to the natural landscapes: showing them flooded areas, touring the lagoons."

"Theres definitely more to paddle.

The islands were hit hard by the heavy spring rains that raised the level of Lake Ontario by two and a half feet. This spring they lost a lot of their beaches, water is pooling in people's yards, and their sewer systems are overwhelmed.

Currently, the islands are technically closed. Theres even a white piece of paper taped to the window of the ticket counter in the ferry terminal which says: Toronto Islands Closed until July 31. But, if you say youre headed over for a day trip, you can get a ticket anyway.

Thats how Aviva Wade says she got over. She says she told the guy selling tickets she was visiting the islands for lunch with a friend. And to check out whats been going on after this unbelievable springtime weve had.

As a visitor, she says shes not particularly bothered by the lack of people on what would usually be a busy summer day.

Its kind of nice, Wade says. Youre going to have the place to yourself.

Besides restaurants and beaches, the islands have another draw, their main attraction the Centre Island Amusement Park.

Its part theme park, part petting zoo, part event space for parties and weddings. The theme park has a log flume, a little Ferris wheel and roller coaster a lot geared for smaller children.

This year the park turns 50. Usually, it would be full of people in the swan boats, eating funnel cakes or taking pony rides. Some would be putting their heads in those plywood cutouts painted like pirates and mermaids and making faces.

But now it's empty. It is here that the islands' closure feels the most dramatic, maybe because abandoned amusement parks are already kind of eerie.

The islands are scheduled to re-open in late July, assuming they dont have any unforeseen problems or lingering health concerns. Workers are worried about standing water breeding mosquitos, or E. coli in the water from sewage problems.

But so far so good. The water continues to go down, and more of the beach is visible every day.

Right now crews are cleaning up the park, getting ready for summer visitors hoping they come back.

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Toronto harbor islands hurt by Lake Ontario flooding - WXXI News

Human Evolution: Africa Exodus Made Homo Sapiens Shorter and Gave Them Arthritis – Newsweek

When the first humans left Africa around 100,000 years ago, they got shorter.

The evolutionary shift helped them cope with the colder conditionsa more compact body size helped protect them from frostbite, whileand shorter limbs would be less breakable when they fellbut it also appears to have come with a downside: arthritis.

In a study published in Nature Genetics on Monday, scientists at Stanford University, California, have shown how variants within the GDF5 gene, which are related to reduced growth, was repeatedly favored by our ancestors as they migrated out of Africa and across the continents.

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But GDF5 has also been linked with osteoarthritis,a degenerative joint disease that affects an estimated 27 million Americans. Risk increases with ageit is sometimes referred to as wear and tear arthritisbut it also has a strong genetic component.

Previous research has shown how mutations in part of the GDF5 gene cause malformation in bone structure in mice. In humans, it has been associated with a shortness and joint problems, and two changes in particular are linked with a heightened risk of osteoarthritis.

In the latest research, the scientists find GDF5 provided an evolutionary boost for our ancestors, with arthritis apparently a byproduct of it."The gene we are studying shows strong signatures of positive selection in many human populations," senior author David Kingsley said in a statement

"It's possible that climbing around in cold environments was enough of a risk factor to select for a protective variant even if it brought along an increase likelihood of an age-related disease like arthritis, which typically doesn't develop until late in life."

A display of a series of skeltons showing the evolution of humans at the Peabody Museum, New Haven, Connecticut, circa 1935. Study finds humans became shorter when they first left Africa 100,000 years ago. Hulton Archive/Getty Images

To better understand GDF5, the team studied the DNA sequences that might affect how the gene is expressedspecifically those that are known as promoters and enhancers. From this they found a previously unidentified region they called GROW1.

When they looked for GROW1 in the 1,000 Genomes Project databasea huge database of genetic sequences of human populations around the worldthe team found a single change that is very common in European and Asian populations, but is hardly ever seen in Africans. The team then introduced this change to mice and found it led to reduced activity in the growth of bones.

They then looked at the change to the genetic variant over the course of human evolution, and found it had been repeatedly favored after Homo sapiens left Africa between 50,000 and 100,000 years ago. The team says the benefits of being shorter in colder conditions probably outweighed the risk of developing osteoarthritis in later life.

Because evolutionary fitness requires successful reproduction, alleles that confer benefits at young or reproductive ages may be positively selected in populations, even if they have some deleterious consequences in post-reproductive ages, they wrote.

Researchers believe this change could help explain why osteoarthritis is rarely seen in Africa, but is more common in other populations.Concluding, Kingsley said: "Because it's been positively selected, this gene variant is present in billions of people. So even though it only increases each person's risk by less than twofold, it's likely responsible for millions of cases of arthritis around the globe.

"This study highlights the intersection between evolution and medicine in really interesting ways, and could help researchers learn more about the molecular causes of arthritis."

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Human Evolution: Africa Exodus Made Homo Sapiens Shorter and Gave Them Arthritis - Newsweek

Here’s where Republicans’ health care plans stand – CNN

Story highlights

Despite tweets on Friday from President Donald Trump and several high-profile Republican senators, the "repeal, then replace later" option is not really on the table and isn't something that will be pursued by GOP leadership as they try to pull together the 50 votes they need to pass their health care plan. Negotiations are continuing as planned for a proposal that repeals and replaces Obamacare simultaneously.

As CNN reported Friday, there is almost no chance senators will vote on a health care bill the week senators return from recess. Expect the health care negotiations to be a multi-week process.

Senate Majority Leader Mitch McConnell is sending several different proposals and basic outlines to the Congressional Budget Office to help speed up the final scoring process, as CNN reported several times last week. Although the top White House legislative official, Marc Short, said Sunday on Fox News that McConnell sent two bills to CBO for scoring; that's not exactly the case. McConnell actually sent two outlines, plus several other proposals that may make it into a final bill.

The future of the proposal continues to depend on whether there is some compromise resolution on the same issues, including a softer landing for the eventual Medicaid reforms and how to craft some acceptable version of Texas Sen. Ted Cruz's regulations amendment into the final proposal. In his comments Sunday, Short appeared to give the White House endorsement to Cruz's regulations proposal, which if so would be no small thing.

Opioid funding and changes to regulations related to the use of health savings accounts appear to be settled and locked in.

A still looming, very real fight that will be coming when they return: whether to repeal the 3.8% investment tax in Obamacare or not. This is not at all settled, but sources tell CNN this is something that won't be dealt with until Congress returns to Washington.

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Here's where Republicans' health care plans stand - CNN

Democrats pressure 2020 senators on health care vote – Politico

Sen. Thom Tillis of North Carolina is one of the first-term GOP senators likely to face a tough battle in 2020. | AP Photo

Few GOP senators are up for reelection in 2018, but polling shows the Republican health care plan unpopular in several key 2020 states.

By Kevin Robillard

07/03/2017 05:21 AM EDT

With few Senate Republicans up for reelection in 2018, Democrats and other groups looking to defeat the GOP's plan to repeal Obamacare are looking to 2020 to pressure politically vulnerable senators.

Save My Care, a progressive group dedicated to defeating repeal attempts, is out with new surveys from the Democratic firm Public Policy Polling showing the GOP proposal, which would cut Medicaid funding and repeal Obamacare's tax increases, is deeply unpopular in Iowa, North Carolina and Colorado three swing states where Republican Senate wins in 2014 helped the GOP gain control of the chamber.

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In Iowa, where Trump won by a wide margin in 2016, 27 percent of voters approve of the bill, and 54 percent disapprove, according to PPP's automated poll in that state. In Colorado, where Clinton won, 26 percent approve and 59 percent disapprove. And in North Carolina, where Trump won by small margin, 33 percent of voters approve and 53 percent disapprove.

All three states have senators who are facing reelection in three years: Sen. Cory Gardner of Colorado, who is also the National Republican Senatorial Committee chairman; Sen. Thom Tillis of North Carolina; and Sen. Joni Ernst of Iowa. Of the three, Ernst is in the strongest position in the Save My Care polling, leading a generic Democratic opponent 48 percent to 41 percent. Tillis is trailing a generic Democrat, 48 percent to 44 percent, and Gardner is trailing 53 percent to 39 percent.

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The polling is designed to show the three senators they may face political peril even if they're not up for reelection in 2018. With narrow margins in the Senate, Democrats are aiming to deter as many Republicans as possible from becoming clear 'yea' votes, starting with Republicans who won seats that were previously held by Democrats during the GOP wave year of 2014.

"There is clear evidence that supporting this health care repeal will do lasting damage to a Senators standing with the voters in their state," strategists with Save My Care wrote in a polling memo. "Voters will reject Senators who support repeal."

The only Republican facing reelection in 2018 in a state won by Democrat Hillary Clinton, Nevada's Dean Heller, has been harshly critical of the GOP proposal. But AARP has run ads attacking the bill in Gardner's Colorado, and in Alaska, the home of Sen. Dan Sullivan. The American Medical Association has also released polling showing the bill is unpopular in Colorado, Alaska and Arkansas.

The Save My Care polls specifically asked whether Congress should continue working to repeal Obamacare or if lawmakers should focus on fixing the law when they return from the Fourth of July recess. In Colorado, voters prefer a fix by 59 percent to 36 percent. In North Carolina, a fix is favored by 53 percent to 40 percent, and in Iowa, the figures are 54 percent to 34 percent.

The polling also shows voters are much less likely to back Republican senators for reelection if they vote for the law, and that large majorities in each state say health care will be one of their top issues during the 2018 midterm elections.

Public Policy Polling conducted the survey of 870 voters in Colorado, 1,102 voters in North Carolina and 784 voters in Iowa on June 30 and July 1. Read the full results for Colorado, North Carolina and Iowa.

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Democrats pressure 2020 senators on health care vote - Politico

‘Don’t take away our healthcare’ says Trump country – BBC News


BBC News
'Don't take away our healthcare' says Trump country
BBC News
The Central Appalachian mountain ranges in Kentucky are home to some of the poorest - and most fervent - Trump supporters. But what happens in the next few weeks hundreds of miles away in Washington could shape their future. Dr Van Breeding is ...

and more »

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'Don't take away our healthcare' says Trump country - BBC News

5 things for Monday, July 3: Trump tweets, health care, an attack in Iraq – CNN

1. Twitter 2. Senate recess Speaking of health care news, Republicans seem to be repealing and replacing that old "repeal and replace" line. Now, some GOP leaders and even Trump himself are floating a possible "repeal now, replace later" approach. 3. Iraq At least 14 people were killed, among them four children and a captain in the Iraqi police, when a suicide bomber detonated a device in a camp for internally displaced people in the Iraqi province of Anbar on Sunday.ISIS claimed responsibility for the attack and said they were targeting members of the Iraqi military. The attack comes as Iraqi forcespush ISIS elements out of their last major Iraqi stronghold, the northern city of Mosul.The city is expected to be fully liberated soon. 4. Arkansas shooting Twenty-eight people were wounded early Saturday in a shooting at a nightclub in Little Rock, Arkansas. In addition to 25 people who were shot, three people were injured in the ensuing chaos. Police believe the incident may be gang-related and likely happened after "some sort of dispute." To add to the confusion, an underground rapper was arrested shortly after the shooting, and a US Marshal initially said the arrest was connected with Saturday morning's incident. It wasn't. So far, no arrests have been made in connection with the shooting. 5. Bernie Sanders Sen. Bernie Sanders on Sunday denied an allegation that his office might have pressured a Vermont bank to speed up the loan process for a real estate acquisition his wife Jane orchestrated for Burlington College while president of the school.Sanders' latest remarks come amid reports the FBI might belooking into the land deal. A vice chair of Vermont's Republican Party, who was also involved in theTrump campaign, brought the accusations to the table last year and called for a federal investigation of Jill Sanders. BREAKFAST BROWSE

People are talking about these. Read up. Join in.

Maine declares a government shutdown over budget standoff

Oh, and essentially the same thing happened in New Jersey too

Canadian PM forgets Alberta while naming the provinces and territories

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Mayor of Mexican town 'weds' crocodile for good luck

Watch a fireworks show ... from above

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5 things for Monday, July 3: Trump tweets, health care, an attack in Iraq - CNN

Fight for what really matters on health care reform – Montana Standard

Too often, policy debates in Washington, D.C., devolve into partisan fistfights. Each side becomes so focused on landing a punch that they forget why they climbed into the ring in the first place.

Just a few years ago, one in five Montanans did not have access to health insurance, and people couldnt afford to get sick.

When we passed health care reform, we took a big step forward, and today, more Montanans have access to health care than ever before.

But the current health care system is not perfect, and there are still folks in Montana who are struggling to pay expensive premiums and high deductibles.

I have heard that message from Plentywood to Libby and everywhere in between as I travel the state holding face-to-face town halls, listening sessions and public events. I know that to bring down the cost of health care we need to do something now, but the Senate health care proposal that was unveiled last week is not the answer.

This partisan bill imposes a tax on folks in their 50s and 60s, and rips health care away from 22 million Americans and tens of thousands of Montanans.

It kicks nearly 80,000 Montanans off Medicaid, many of whom now have health insurance for the first time.

It threatens coverage for folks with pre-existing conditions like high-blood pressure and diabetes.

It could bring back the days of lifetime caps when folks paid for health insurance their entire lives, but were booted off when they needed coverage the most.

The bill fails to address the very issue Montanans need us to tackle: the rising cost of health care. And it ignores families who are facing another round of premiums hikes next year.

But it doesnt ignore the wealthiest Americans who will see $541 billion in tax breaks.

If this bill passes, working families will pay more money for less coverage, while millionaires and big corporations walk away with fatter wallets.

While some elected officials continue to prioritize scoring political points, I still remember why I got in the ring to fight for Montana.

I am willing to sit down with Republicans, Democrats, independents, and Libertarians and come up with a solution that keeps whats working in our current health care system and improves where it falls short.

I am optimistic that we can pass a good health care bill that works for every Montanan, but this will only happen if it is done in a bipartisan, transparent way with input from folks of all walks of life.

The final vote on the disastrous Senate health care bill was delayed because thousands of Montanans raised their voices together. Now it is time to throw in the towel on partisan bickering, and start fighting for what really matters.

-- Jon Tester, a farmer from Big Sandy, is Montanas senior U.S. senator.

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Fight for what really matters on health care reform - Montana Standard

33 percent in NC approve of Senate health care bill, Raleigh-based poll finds – News & Observer (blog)


News & Observer (blog)
33 percent in NC approve of Senate health care bill, Raleigh-based poll finds
News & Observer (blog)
When Senate Republicans return to the U.S. Capitol next week, their top priority will be passing their version of a now-stalled health care repeal-and-replace bill. But the Better Care Reconciliation Act is not that popular among North Carolinians ...

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33 percent in NC approve of Senate health care bill, Raleigh-based poll finds - News & Observer (blog)

Decreasing height, increasing arthritis risk evolutionarily advantageous for humans – Stanford Medical Center Report

Many people think of osteoarthritis as a kind of wear-and-tear disease, but theres clearly a genetic component at work here as well.

The researchers were studying a gene called GDF5 that Kingsleys laboratory first linked to skeletal growth in the early 1990s. GDF5 is involved in bone growth and joint formation, and mutations in the coding portion of the gene have been shown to cause malformations in leg-bone structure in mice. In humans, GDF5 mutations are associated with shorter stature and joint problems; in particular, two nucleotide changes immediately upstream of the gene have been strongly associated with a 1.2- to 1.8-fold increase in the risk of osteoarthritis.

In the new study, the researchers were interested in learning more about how the DNA sequences surrounding GDF5 might affect the genes expression. Often, these noncoding sequences contain key regulatory regions known as promoters and enhancers. Capellini, Chen and Cao were able to identify a previously unknown enhancer region they termed GROW1, which is several thousand nucleotides downstream of GDF5.

When the researchers analyzed the sequence of GROW1 in the 1,000 Genomes Project database, which collects and compares sequences from many human populations around the globe, they identified a single nucleotide change that is highly prevalent in Europeans and Asians but that rarely occurs in Africans. When they introduced this nucleotide change into laboratory mice, they found that it decreased the activity of GDF5 in the growth plates of the long bones of fetal mice.

Further research showed that this nucleotide change has been repeatedly favored during human evolution. Modern humans migrated from Africa between 50,000 and 100,000 years ago. But they werent the first to leave the continent. Neanderthals and Denisovans moved north into Europe and Asia about 600,000 years ago. Interestingly, the researchers found that the same GROW1 variant was found in the DNA of both ancient and modern humans in Europe and Asia.

However, theres a dark side to this stocky, hardy body type: The GDF5 variant that reduces bone length comes hand-in-hand with the two upstream nucleotide changes known to confer an increased risk for osteoarthritis.

Its clear that the genetic machinery around a gene can have a dramatic impact on how it works, said Capellini. The variant that decreases height is lowering the activity ofGDF5in the growth plates of the bone. Interestingly, the region that harbors this variant is closely linked to other mutations that affect GDF5 activity in the joints, increasing the risk of osteoarthritis in the knee and hip.

The potential medical impact of the finding is very interesting because so many people are affected, said Kingsley. This is an incredibly prevalent, and ancient, variant. Many people think of osteoarthritis as a kind of wear-and-tear disease, but theres clearly a genetic component at work here as well. Now weve shown that positive evolutionary selection has given rise to one of the most common height variants and arthritis risk factors known in human populations.

Researchers from the University of Waterloo in Ontario, Canada, also contributed to the study.

The research was supported by the National Sciences and Engineering Research Council of Canada, the Arthritis Foundation, the National Institutes of Health (grant AR42236), the Howard Hughes Medical Institute, the Milton Fund of Harvard, the China Scholarship Council and the Jason S. Bailey Fund of Harvard.

Stanfords Department of Developmental Biology also supported the work.

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Decreasing height, increasing arthritis risk evolutionarily advantageous for humans - Stanford Medical Center Report

Trump and Pope Weigh In on Case of UK Child on Life Support – New York Times

Three courts in Britain agreed with the hospital, as did the European Court of Human Rights, which last week rejected a last-ditch appeal by Charlies parents.

But Pope Francis and Mr. Trump have also weighed in, adding another dimension to an extraordinarily thorny bioethical and legal dispute that pits Britains medical and judicial establishment against the wishes of the childs parents.

Judges in the case have acknowledged that the case highlights differences in law and medicine and an American willingness to try anything, however unlikely the possibility of success but have held that prolonging the infants life would be inhumane and unreasonable. The case echoes the one of Terri Schiavo, a Florida woman who was left in a persistent vegetative state after a cardiac arrest and was also the subject of a court battle.

A Vatican spokesman, Greg Burke, told Vatican Radio on Sunday that the pope had been following the parents case with affection and sadness, praying that their desire to accompany and care for their own child to the end is not ignored.

Mr. Trump, who was not known to have previously expressed a view on the matter, wrote on Twitter on Monday that if the United States could help, we would be delighted to do so.

Both the pope and the president stopped short of criticizing the court rulings or the hospital. Helen Aguirre Ferr, the director of the White House office of media affairs, said Mr. Trump had decided to speak out after he learned about this heartbreaking situation. Mr. Trump has not spoken with the family, she said, and does not want to pressure them in any way.

The president is just trying to be helpful if at all possible, she added.

Charlie was born on Aug. 4, 2016, with encephalomyopathic mitochondrial DNA depletion syndrome. He is thought to be one of only 16 children globally with the condition, the result of a genetic mutation.

Brendan Lee, the chairman of the department of molecular and human genetics at Baylor College of Medicine, who is not involved the case, said in a phone interview that mitochondrial depletion syndrome has no cure. Treatments involve different types of vitamin supplementation, but none have been shown to definitively work through studies, he said.

Charlies parents, Connie Yates and Chris Gard, both in their 30s, have been waging a long and wrenching legal battle to keep him alive. They have raised more than 1.3 million pounds, or about $1.7 million, to help finance experimental treatment in the United States. There is also an international campaign, with an online petition and there have been street protests in front of Buckingham Palace.

Charlie has been treated since October at Great Ormond Street Hospital, where doctors eventually decided that withdrawing life support was the only justifiable option. Although Charlies parents have parental responsibility, overriding control is by law vested in the court exercising its independent and objective judgment in the childs best interests, the hospital said in a statement laying out its position.

Siding with the hospital were the High Court, on April 11; the Court of Appeal, on May 25; and the Supreme Court of the United Kingdom, on June 8.

The High Court ruled that Charlie would face significant harm if his suffering were to be prolonged without any realistic prospect of improvement. Moreover, it said the experimental treatment, known as nucleoside therapy, would not be effective.

Money is not at issue; an academic medical center in the United States has offered to provide the experimental treatment. But a neurologist at the hospital, who has offered to oversee the treatment, told the court by telephone: I can understand the opinion that he is so severely affected by encephalopathy that any attempt at therapy would be futile. I agree that it is very unlikely that he will improve with that therapy.

Neither the hospital nor the neurologist was identified in court documents, and the White House has declined to identify either.

The Court of Human Rights ruled last week that the British courts had acted appropriately in concluding that it was most likely Charlie was being exposed to continued pain, suffering and distress, and that undergoing experimental treatment with no prospects of success would offer no benefit, and continue to cause him significant harm.

The case has drawn attention to important differences in legal systems.

Claire Fenton-Glynn, a legal scholar at the University of Cambridge who studies childrens rights, said that under British law, the courts were the final arbiter in medical disputes about the treatment of children.

She noted a 2001 case of conjoined twins, Jodie and Mary, who were born sharing an aorta. Separating the twins would lead to the death of the weaker twin; if they were not separated, both would die. A court ruled that the twins should be separated against the wishes of their parents; as expected, one died.

Courts in the United States are less inclined to get involved when there are disputes between parents and doctors, said Professor Moreno of the University of Pennsylvania, stressing that it was usually left to doctors, in consultation with parents, to decide on a childs treatment.

He noted the case of Baby Jane Doe, who was born in 1983 with spina bifida and whose parents declined to approve surgery to prolong her life. That case led to a law, signed by President Ronald Reagan, that defined instances in which withholding medical treatment from infants could be considered child abuse, but also provided that in certain cases doctors and parents might choose to withhold treatment from seriously handicapped babies when such action would merely prolong dying.

G. Kevin Donovan, the director of the Pellegrino Center for Clinic Bioethics at Georgetown University Medical Center and a professor of pediatrics, said that in the United States, if parents insisted on continuing life-prolonging treatment against a doctors advice, the child would simply be transferred to another institution willing to comply with the parents wishes.

It doesnt seem to be a supportable position morally or ethically, he said of the stance taken by the hospital in London, adding that what is legal and what is ethical are not always the same.

In the Schiavo case, her husband, who was her legal guardian, wanted to have her feeding tube removed, but her parents disagreed, setting off a seven-year fight that ended in 2005, after courts ruled in the husbands favor. Life support was removed from Ms. Schiavo, who died at 41.

In that case, too, the pope, then John Paul II, and the president, George W. Bush, weighed in. Mr. Bush signed an act of Congress allowing federal courts to intercede in the case. But their interventions did not ultimately affect the outcome.

There was no immediate response to Mr. Trumps statement from Charlies parents, who last week appeared to accept the finality of the courts rulings. Photographs of the couple sleeping with their sick child have circulated on social media recently.

We are really grateful for all the support from the public at this extremely difficult time, Ms. Yates said on Friday. Were making precious memories that we can treasure forever with very heavy hearts. Please respect our privacy while we prepare to say the final goodbye to our son Charlie.

There was also no immediate reaction from the hospital.

In Charlies case we have been discussing for many months how the withdrawal of treatment may work, the hospital said. There would be no rush for any action to be taken immediately. It added that it would consult the family and that discussions and planning in these situations usually take some days.

Follow Dan Bilefsky @DanBilefsky and Sewell Chan @sewellchan on Twitter.

Aneri Pattani and Roni Caryn Rabin contributed reporting from New York, and Michael D. Shear from Washington.

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Trump and Pope Weigh In on Case of UK Child on Life Support - New York Times

Genetic variant linked to osteoarthritis favored in cold climates – Scope (blog)

Like many others, Ive been rewatching the Game of Thronestelevision series in preparation for the start of the seventh season later this month. So I dont think its all that odd that an image of Jon Snows first trip to the jaw-dropping Wall of ice (which rises 700 feet high) in the frozen north of Westeros popped up in my head as I began research for my latest release about human evolution, migration and genetic selection.

You see, like Snow, our early human ancestors moved north out of Africa into the much colder climates of Europe and Asiatens of thousands of years ago. And as their surroundings and weather changed, they adapted to these changing conditions by passing on genes that would enhance their descendants chances of survival. Paradoxically, however, this fancy genetic footwork seems to have favored a DNA sequence that not only reduces human height, but also increases the risk of osteoarthritis. It seems somewhat contrary to the survival of the fittest mantra that we all learned in high school.

The researchers, Stanford developmental biologist David Kingsley, PhD, and Harvard human evolutionary biologist Terence Capellini, PhD,Harvard graduate studentJiaxue Cao, and former Stanford postdoctoral scholarHao Chen, PhD, published their findings today in Nature Genetics.

From our release:

Now, researchers at the Stanford University School of Medicine and at Harvard University have shown that, despite its association with the painful joint disease, this genetic variant has been repeatedly favored as early humans migrated out of Africa and into colder northern climates. At least half of Europeans and Asians harbor the gene variant, which is relatively rare in African populations. []

A more compact body structure due to shorter bones could have helped our ancestors better withstand frostbite and reduce the risk of bone fracture from falling, the researchers speculate. These advantages in dealing with chilly temperatures and icy surfaces may have outweighed the threat of osteoarthritis, which usually occurs after prime reproductive age.

It wasnt just our early human ancestors who hit upon this solution, the researchers found. Our even more ancient cousins, the Neanderthals and the Denisovans, also singled out this same gene variant (through a process known in genetic circles as positive selection) when they left Africa about 600,000 years ago. Its evolutionary popularity means it is now present in billions of people.

As Kingsley explained:

The potential medical impact of the finding is very interesting because so many people are affected. This is an incredibly prevalent, and ancient, variant. Many people think of osteoarthritis as a kind of wear-and-tear disease, but theres clearly a genetic component at work here as well. Now weve shown that positive evolutionary selection has given rise to one of the most common height variants and arthritis risk factors known in human populations.

Previously: From whence the big toe? Stanford researchers investigate the genetics of upright walking, Its a blond thing: Stanford researchers suss out the molecular basis of hair colorand Comprehensive review of humans expansion out of Africa could lead to medical advances Photo by Jeff S. PhotoArt at HDCanvas.ca

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Genetic variant linked to osteoarthritis favored in cold climates - Scope (blog)

"Demolishing The Futurist Was The Right Thing To Do" – Yorkshire Coast Radio

Demolishing Scarborough's Futurist Theatre was the right thing to do.

That's the view of the Leader of Scarborough Borough Council, Councillor Derek Bastiman. Last month we told about the recent decision by a High Court judge not to allow a case against the borough council, brought by campaigners from the Save the Futurist Group trying to save the venue.

The campaign group was also told to pay costs to the borough council of 10,000. The group wanted a judicial review into the council's decision to demolish the building, which was decided back in January.

Derek said:

"The outcome was what I expected because I believe that this authority has done everything in a correct, right and proper manner.

In fact the Ombudsman found in our favour that everything had been done in the right manner.

So I don't mind this authority being taken to court because I know, through the legal advice that we obtained, we did everything right and proper.

There was a lot of opposition, but by the same token, I got and still get some horrible emails and letters addressed to me.

They have no sense of decency whatsoever. They've accused me and others of doing all kinds of things.

I have always done what I think is fair and right, and I think the decision to demolish the Futurist was right. "

Listen to Derek's interview with Yorkshire Coast Radio's Jon Burke below:

The judicial review was lodged in April, and the Save the Futurist Campaign Group becameSave The Futurist Theatre (Scarborough) Ltd.

They were tasked with raising 10,000 in order to fund legal services and a further 6,000 to cover specialist legal advice.

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"Demolishing The Futurist Was The Right Thing To Do" - Yorkshire Coast Radio

Ray Kurzweil: There’s a Blueprint for the Master Algorithm in Our Brains – Futurism

In Brief Ray Kurzweil, Google's chief engineer, is a famous futurist who's always banked on the coming of the singularity when artificial intelligence overcomes human intelligence. For that to happen, however, we need to figure out the master algorithm.

Todays artificial intelligence (AI) systems are, no doubt, considerably advanced. There are now intelligent machine learning algorithms capable of driving vehicles, assisting doctors, or even engaging in art and in almost-human conversation. However, despite AI programmed as artificial deep neural networks, these are still far from actually mimicking what the human brain is capable of.

Renowned futurist and Google engineer Ray Kurzweil thinks that the key to human-level AIis a master algorithm, and he believes that the brain holdsa blueprint to this. The famous inventor and thinker, known for his mostly accurate predictions about future technologies, said that the brains neocortex that part of the brain thats responsible for intelligent behavior consists of roughly 300 million modules that recognize patterns. These modules are self-organized into hierarchies that turn simple patterns into complex concepts.

Despite neuroscience advancing by leaps and bounds over the years, we still havent quite figured out how the neocortex works. Kurzweil argued that these multiple modules all have the same algorithm, he said in the video by the Singularity Universityposted above. The mathematics of thinking, I think, is being understood, Kurzweil added, but I would not claim that we understand it fully. But were getting more and more hints as we learn more and more about the human brain.

Perhaps soon enough, well figure out that master algorithm and understand our brains better. Then well either be able to make better AI or AI thats better than us. Its worth finding out.

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Ray Kurzweil: There's a Blueprint for the Master Algorithm in Our Brains - Futurism

Get Ready. The Tesla Model 3 Goes on Sale This Week. – Futurism

In Brief The Tesla Model 3 is about to hit the streets. CEO Elon Musk announced via Twitter that, after passing all regulatory requirements, the first series of Model 3s could be out by Friday this week. Arrival of the Tesla Model 3

When it comes to Elon Musks ventures, it seems like theres alwayssomething to look forward to. This past weekendSpaceX launched itsthird mission in nine days which came after their historic doubleheader last weekend.Then theres the progress on MusksBoring tunnels under L.A.But the most recent announcement hadmore than 400,000 peoplein wait; those who have signed up for pre-orders for the Tesla Model 3.

In a tweet Sunday night, Musk said that the Model 3 has already passed regulatory hurdles.

He expects that the serial number 1 (SN1) for Teslas electric vehicle will be finished by the end of this week. Musk also said in a second tweet that the handover party for the first 30 Model 3 customers will take place on the 28th of this month.

Musk was clearly pleased to make the announcement, and hed done the legwork ahead of potential questions, too. He also shared on Twitter just how manyModel 3s are expected to berolled out by the end of 2017. Continuing on in his Twitter thread, the Tesla CEO said that they expect 100 cars by August and over1,500 by September. By December, Tesla hopes to be producing20,000 Model 3s per month.

It should come as no surprise that Tesla has ramped up production for the Model 3. Previous reports revealedtheModel 3 production line runs onwhat Musk called an alien dreadnaught of Kuka robots. This was certainly the right move,considering the amount of pre-orders Tesla received for the Model 3 was staggering.

While the Model 3 is Teslas most affordable EV yet, the energy company isnt going cheap in terms of its design and capabilities, which will includeTeslas self-driving Autopilot software.

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Get Ready. The Tesla Model 3 Goes on Sale This Week. - Futurism

Dubai Announces Accelerator to Solve the 21st Century’s Most Pressing Challenges – Futurism

A Hub of Ideas

Dubai is already leading the world in a number of innovative conceptsthey have plans for a Hyperloop system, a robot police force,a store that changes shape,self-driving electric vehicles,flying taxis,a space agency that will work towards getting people to Marsand this is just the beginning.

Now, its looking to continue that trend through a unique and innovative program that gathers the worlds industry leaders with key figures in government in order to solve some of humanitys greatest challenges.

The Dubai Future Accelerators is an intensive nine-week program that aims to connect the most innovative companieswith partners in the government in order to bring to life viable futuristic prototypes at a city-wide scale. Their goal is to actually testthe technologies that could be the solutions to some of thechallenges that plague modern society.Our mission is to imagine, design and create the future by facilitating partnerships between forward-thinking entrepreneurs and the government using the city of Dubai as a living testbed, the programs website notes.

For the program, they are focusing on seven key opportunities of the 21st century. This includes the application of cutting edge technologies like AI and robotics, genomics, 3D printing, distributed ledgers, biomimicry, and biotechnology, as well as new business models and ways of working, notesthe programs organizer, the Dubai Future Foundation (DFF).

Together, these focal points represent the most pressing sectors that could accelerate society into a new age of efficiency,productivity, and abundance. Each of the seven sectors act as umbrellas, housing a number of opportunities for innovation beneath them.

Applications for the third run of the program, which will go from October 1 to November 29, are already open. Interested companies have to be familiar with the challenges defined by the DFFs government partners and then choose one theyd like to focus on before filling out the application form.

The challenges come from a number of Dubais government offices, including the Roads and Transport Authority, the Dubai Police, the citys Health Authority, and the Department of Economic Development.

In the official release, Maha Khamis Al Mazeina, Project Manager at Dubai Future Foundation, noted that the program is really all about setting a course and tone for the future: The Dubai Future Accelerators program embodies the strategies set by the UAE as the country aims to lead the global charge to build the future, focusing on the strategic sectors that most affect peoples lives in the UAE and abroad.

To that extent, the program is doing a lot more than uniting governing officials with tech execs. They are inspiring the coming generations. For example, events held by the Dubai Future Accelerators will include members of the community, such as their Masterclass a series of interactive workshops that are meant to provide a comprehensive introduction to some of the technologies of the future and how to use them to benefit society.

Other events will be less like classes and more like discussion panels, where individuals can come together to ask the best and brightest about their ideas regarding how to build a better tomorrow. Such sessions will be hosted by international experts and participants in the Accelerators program, and they will explore the impact that these latest trends will have (and are having) on people today and tomorrow.

This is not a traditional accelerator. This isnt about how to write a business plan or how to pitch your startup. Its not about coding languages or search engine optimization. We arent going to tell you how to run your business or how to develop your website, the DFF says.This is about changing the world. Today.

So, if youthink that you might be able to help address one of the problems listed above, consider applying at the website by sending along a proposal,and if selected, you could be heading toDubai to help usher in a better tomorrow.

Disclosure: The Dubai Future Foundation works in collaboration with Futurism and is one of our sponsors. This post was not paid for or edited by DFF.

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Dubai Announces Accelerator to Solve the 21st Century's Most Pressing Challenges - Futurism

SpaceX is Launching Its Third Mission in Just Nine Days – Futurism

In Brief SpaceX is launching yet another Falcon 9 rocket later this evening, its third launch in just nine days. The company is burning through the backlog caused by the Falcon 9 disaster last September. Hefty Launch

SpaceX is gearing up for yet another launch into space this weekend weather-permitting. Sundays launch will be the third for SpaceX in just nine days, and the 39th Falcon 9 rocket launch. The mission is to put a massive communications satellite into orbit for the company Intelsat. Takeoff is scheduled for tonight at 7:36 PM EDT from Kennedy Space Center in Florida. You can watch the launch liveat Space.com.

What sets this launch apart from the other recent missions is that the client is not interested in utilizing reusable rocket tech. Ken Lee, senior vice president for space systems for Intelsat said, I would have no qualms about using the pre-flown hardware in the future once they have fully demonstrated their reusability, which he defines as [t]ypicallya minimum of three. As of now, SpaceX has managed to launch and land a reusable rocket twice. Also, given the heft of the satellite, the booster will not have enough fuel to make the journey back to the surface.

SpaceX did have a sizable backlog of planned launches due to the unfortunate catastrophe where a Falcon 9 rocket exploded at launch. However, in the first half of 2017, SpaceX has already broken its previous record for launches in a single year. They are planning for a total of 20 launches before the end of 2017. This is important to Intelsat, and likely other entities looking to use SpaceXs tech to get into space. Whats important for us is not whether you launch every other week, but [that] once you plan, you execute to that plan, Lee said.

SpaceX is well on its way to definitively proving the reliability of their rockets. While the price difference of using the reusable boosters may not be enough at this time for Intelsat, the price difference will continue to drop as the rocketscontinue to be reused. SpaceX is pioneering in this field and is revolutionizing what it takes to get into space.

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SpaceX is Launching Its Third Mission in Just Nine Days - Futurism

Trump’s Celebration of an Exclusionary Vision of Freedom – The Atlantic

On Saturday night, roughly 12 hours after tweeting that Mika Brzezinski was dumb as a rock and 12 hours before tweeting a video of himself side-slamming CNN, Donald Trump spoke at a Celebrate Freedom Concert at Washingtons Kennedy Center. Journalists covering the event focused on Trumps jabs at the media. But they missed his veiled attack on another group of Americans whose First Amendment rights he threatens: Muslims.

In his remarks, Trump promised (in July!) that, Were going to start saying Merry Christmas again. He referred repeatedly to our God. And he explained that, we want to make sure that anyone who wants to join our country shares our values.

By Trumps standards, those comments might sound anodyne. But consider his audience. The Celebrate Freedom Concert was co-hosted by the First Baptist Church of Dallas. Warming up the crowd before Trump spoke were the churchs choir and orchestra and its senior pastor, Robert Jeffress, one of Trumps favorite evangelicals. During the campaign, when other Christian leaders were criticizing Trumps vulgarity and religious illiteracy, Jeffress declared that, I dont care about that candidates tone or vocabulary, I want the meanest, toughest, son of a you-know-what I can findand I believe thats biblical. Christians, he explained, should look for a strongman. Jeffress later said he was getting sick and tired of these namby-pamby, pantywaisted, weak-kneed Christians who say theyre going to stay home in November out of moral principle.

Trump rewarded Jeffress by inviting him to give the sermon at the church service he attended on inauguration morning. In his remarks, Jeffress told Trump that, I dont believe we have ever had a president with as many natural gifts as you. In May, Trump invited Jeffress to the White House to watch him sign an executive order on religious liberty. As the Messiah College professor John Fea has noted, many Christian conservatives derided Trumps move as meaningless and useless. Not Jeffress, who called Trump the most faith-friendly president in U.S. history. In introducing him at the Freedom Concert on Saturday night, Jeffress said the President has not only met but he has exceeded our every expectation and that we thank God every day that he gave us a leader like Donald Trump

But Jeffress and Trump share more than just a high opinion of Donald Trump. They share a deep antipathy toward Muslims and Islam. Jeffress, to be fair, isnt exactly ecumenical when it comes to any other faith. Hes called Buddhism and Hinduism false religions. Hes said, you cant be saved being a Jew. Hes called Mormonism a cult. And hes called Catholicism a counterfeit religion invented by Satan.

But hes saved his harshest and most extensive vitriol for Islam. In 2010, Jeffress criticized conservatives who opposed building an Islamic Community Center near Ground Zero in lower Manhattan merely because they considered the location insensitive. Jeffress offered a broader justification. The only argument that makes sense against building that mosque, he insisted, is that Islam is an oppressive religion. Islam, he added, is a religion that promotes pedophilia. It is time to take off the gloves and stand up and tell the truth about this evil, evil religion. Jeffress logic, needless to say, justifies opposing the construction of a mosque anywhere in the United States.

In 2015, Jeffress showed up Fox News to defend Ben Carsons claim that a Muslim should not be president. Jeffress explained that he could only vote for a Muslim who disavowed portions of the Koran and renounce[d] Mohammed. That same year, Jeffress called the Koran a false book, Mohammed a false prophet and Islam a false religion that will lead you to hell. Last July, he declared that, Mohammad was nothing but a bloodthirsty warlord. And last March, he said President Obama was once again assuming his favorite role, not as commander in chief but as defender in chief of Islam. By contrast, Jeffress insisted, Donald Trumps statements that Islam hates us was absolutely true. There is something within Islam that is engendering this hatred toward the rest of the world Trump is telling the politically incorrect truth.

Jeffress also shares Trumps enthusiasm for the words Merry Christmas. In 2015 he actually created a website that listed the Dallas-area businesses that used the salutation (they received the honorific nice) and those that did not (which were classified as naughty). But Trumps promotion of the phrase takes on a different meaning at an event co-sponsored by an avowed anti-Muslim bigot. So do Trumps references to our God and his declaration that we want to make sure that anyone who wants to join our country shares our values.

What values, after all, do Trump and Jeffress share? Not a commitment to marital fidelity. Not a commitment to honesty, charity, or humility. The value that unites them, above allthe one that led Jeffress to favor Trump over his more devout, more socially conservative Republican rivals during the primariesis their shared belief that the American government should favor Christianity over Islam. Thats the odd form of freedom they celebrated together at the Kennedy Center on Saturday night.

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Trump's Celebration of an Exclusionary Vision of Freedom - The Atlantic

Keeping Freedom, and Growth, in the Fourth – National Review

What is the Fourth of July? Its a wonderful time. Were outdoors. Were with family and friends. Were playing golf or fishing. There are barbecues and baseball and fireworks and all that good stuff.

And beneath it all, supporting it all, there is freedom. Freedom. The Fourth of July is about freedom, if nothing else. Americas freedom, of course. But a freedom that extends to all people. One that leads to greatness and prosperity. A freedom that has become the backbone of the world.

I would like to take a moment this holiday to revisit the sources of that freedom. They were outlined so eloquently in perhaps the greatest document ever written, the Declaration of Independence. And theyre as crucial now as they were 241 years ago.

Its a well-known story. Back in 1776, the Continental Congress sought freedom from tyranny. They said, Were revolting against a British monarchy and parliament that doesnt represent us. Were rebelling against laws we dont control and are capricious to say the least.

To formalize this revolt, the congress formed a committee of five. Chosen were Thomas Jefferson, Robert Livingstone (New Jersey), John Adams, Ben Franklin, and Roger Sherman (Connecticut). A pretty spiffy group of thinkers and writers.

Their task was to draft a statement of independence although what they came up with was so much more.

Their document, The Unanimous Declaration of the thirteen united States of America, was adopted on July 4, 1776, after days of debate and revision. The document begins:

When in the Course of human events it becomes necessary for one people to dissolve the political bands which have connected them with another and to assume among the powers of the earth, the separate and equal station to which the Laws of Nature and of Natures God entitle them, a decent respect to the opinions of mankind requires that they should declare the causes which impel them to the separation.

Id like to underscore the civility of that opening. This document is an example of civility. The great American revolt was a defense of the right of discussion. Civil discourse. Respectful disagreement.

Then there are The Laws of Nature and Natures God. We derive our freedoms not from governments, but from God. It was a revolutionary thought at a time when dictatorial monarchs across Europe believed they were gods.

Then we have perhaps the most famous sentence in the English language, if any language:

We hold these truths to be self-evident, that all men are created equal, that they are endowed by their Creator with certain unalienable Rights, that among these are Life, Liberty and the pursuit of Happiness.

That truly was revolutionary stuff. And it was beyond just the colonies.

The authors were saying, Were speaking about the people here, but also about oppressed peoples everywhere, those burdened with dictatorial, who-cares-about-the-little-people governments.

And they spoke of life, liberty, and the pursuit of happiness.

Life. Our very existence.

Liberty. You cant take my freedom away.

The pursuit of happiness. To live the way we want to live, to do the work we want to do, to marry whom we want to marry; to have kids, accumulate property, and be prosperous.

Ive said this often: The most populist desire of the people of the United States and other free nations is long-lasting, deep-seated prosperity. Speaking of which, the long list of complaints against George IIIs Britain included: cutting off our Trade with all parts of the world (protectionism), imposing Taxes on us without our Consent (remedied with supply-side tax cuts), and (hat tip Seth Lipsky, New York Sun) a hint of stable money: the amount and payment of [judges] salaries.

But the Declaration, critically, goes on:

That to secure these rights, Governments are instituted among Men, deriving their just powers from the consent of the governed, That whenever any Form of Government becomes destructive of these ends, it is the Right of the People to alter or to abolish it, and to institute new Government.

Taking these statements together, we see a pecking order. There is God, a higher power or Natures God, who grants us the unalienable rights of life, liberty, and the pursuit of happiness. And whatever government is formed around this works for the people. And if the government lacks the consent of the people, there must be great change.

From the Lord, to us, and then to government.

And when government breaks down, does poorly, or becomes corrupt, it needs to be replaced one way or another.

Theres a little bit of that going on today, is there not?

Its the Fourth of July. Its freedom day. The government works for us, not the other way around.

If it doesnt, the government gets kicked out on its keister.

Larry Kudlow is CNBCs senior contributor. His new book is JFK and the Reagan Revolution: A Secret History of American Prosperity, written with Brian Domitrovic.

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Keeping Freedom, and Growth, in the Fourth - National Review

Report: Attacks On Religious Freedom Increased 76 Percent In 3 … – The Federalist

More than 200 years ago, the young United States was learning to walk in its freshly won freedom and the Constitution born of it. Our experiment in self-governance, based on the idea that our Creator endowed all of us with certain inalienable rights as reflected in our Declaration of Independence, was unique in the history of the world.

Among these rightswhich we recognize are not given by government but granted by Godis our right to religious freedom. Its importance is signified by the fact that it precedes all the other rights listed in the amendments to our Constitution.

In our early years, imperfect to be sure, as a nation we nevertheless persisted and advanced to embrace the ideal of religious freedom articulated in the First Amendment to our Constitution. That we are still governed by the same Constitution after more than 200 years is itself a miracle, and speaks to the vigilance Americans have exercised and must continue to exercise to guard our freedom.

Generations later, hostility to religion in the public square of the United States has grown significantly. The changes may seem incremental until one compares the social situation at the time of our founding with our present state. Religion was embraced then, and is censored now. It was esteemed at that time; these days it is often disparaged.

From militant atheist hostility to the presence of religious symbols in public and expressions of religious belief by government actors, to government hostility to religious beliefs regarding sexuality, the overall climate for the religious believer is one of apprehension at best. Indeed, some have lost their jobs or been financially penalized due to their beliefsright here in the United States.

To track and address these troubling developments, Family Research Council released a report in 2014 titled Hostility to Religion: The Growing Threat to Religious Liberty in the United States. It documented accounts of hostility toward faith in the United States today, defined in four areas: (1) Suppression of Religious Expression in the Public Square; (2) Suppression of Religious Expression in Schools and Universities; (3) Censure of Religious Viewpoints Regarding Sexuality; and (4) Suppression of Religious Expression on Sexuality Using Nondiscrimination Laws. That catalogue of violations, spanning over ten years, contained 90 incidents.

Many would likely suspect that religious freedom troubles have grown worse during the past three years. They would be correct. Just this past week, we released the updated 2017 report, which showsconservatively estimateda 76 percent increase in overall religious freedom violations documented over the past three years.

The last two sections, dealing with human sexuality, have seen a 114 percent surge. These types of incidents were already on the rise, and the Supreme Courts decision in Obergefell v. Hodges only accelerated the trend. If one reads through the last two sections, many cases will be familiar from the news and cultural discussion. Among those featured is the story of Jack Phillips, the Colorado baker who was sued after he obeyed his conscience and politely declined to create a wedding cake for a same-sex wedding ceremony. The Supreme Court accepted his case for review just several days ago, and will decide it during the next term.

The first step toward action is information. We hope this report will serve as a resource for those who wonder about the state of religious freedom in America. It can also be useful to those who wonder where the evidence is when others cite a trend of religious freedom violations. With this information, our representatives can respond appropriately. Concerned citizens can engage with the media and in their communities. Certainly, our religious freedom problems could be much worse. But our goal is not to get to that much worse place.

When Communism began to spread during the beginning of the twentieth century, many ignored or brushed off concerns as relatively mild, especially in light of other concerns at the time. Only when it was too late and the grip of authoritarian regimes was strong did many realize the horror and carnage that the ideology had wrought worldwide. This is clear in hindsight but was not so apparent at the time.

Our country has been blessed with a long history of freedom. On its birthday, it is appropriate to be thankful and reflect on how we can guard against the suppression of religious freedom we do see now before it is too late. If we Americans can acknowledge the troubling trends now, and work to reverse them while we still have the freedom to do so, we will have a future America that embraces liberty and remains free for all.

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Report: Attacks On Religious Freedom Increased 76 Percent In 3 ... - The Federalist

‘Freedom’: Minnesota liquor stores now legally open Sundays – ABC News

Minnesota residents have the option of purchasing alcohol from their local liquor store on a Sunday for the first time in history.

Alcohol retailers are allowed to remain open from 11 a.m. to 6 p.m. Sundays now that Minnesota has ended its more than century-old ban on Sunday liquor sales, the Star Tribune ( http://strib.mn/2tfKUeb ) reported.

Previously, residents who wanted a drink on Sunday had to head to a bar or drive to a liquor store in Wisconsin.

"It feels as if a freedom has been lifted," said Fred Kreider, who went to Zipps Liquors in Minneapolis to buy a keg of beer Sunday.

Sales were brisk for Zipps Liquor during the first day of the new law, said owner Jennifer Schoenzeit.

Liquor vendors in Wisconsin said they didn't notice a difference in their sales.

"We're open 13 hours, and six of those hours Minnesota is closed," said Shelton Davis, the night manager at Chicones Liquor Mart in Hudson, Wisconsin. "We don't panic; we've got good deals."

Ending the ban could lead to further deregulation, said Minnesota Municipal Beverage Association Executive Director Paul Kaspszak. Grocery stores, convenience stories and big-box retailers such as Total Wine may lobby for fewer restrictions, he said.

"All of a sudden they want to sell chardonnay with the Cheerios, and they want to sell beer with the chicken and then we have a problem," Kaspszak said.

The increased operating costs of staying open an additional day are also a cause of concern, said Buffalo Lake Liquor manager Karissa Kurth.

Some store owners fear the increased overhead will make it difficult for small family-owned stores to compete against bigger retailers.

North St. Paul's Brightwines is a one-man shop that specializes in high-quality wines.

"This law is not designed to help us; this, in fact, ignores us," said owner Dave Kuennen.

Information from: Star Tribune, http://www.startribune.com

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'Freedom': Minnesota liquor stores now legally open Sundays - ABC News