Tevye the Milkman, Libertarianism, and the Open Borders Fantasy – Ricochet.com

Political freedom and escape from tyranny demand that individuals not be unreasonably constrained by government in the crossing of political boundaries. Economic freedom demands the unrestricted movement of human as well as financial capital across national borders Paragraph 3.4 of the 2016 Libertarian Party platform

I have nothing against Libertarians. In fact, some of my best friends are Libertarians. If one of my children wanted to marry a Libertarian, like Tevye the Milkman I would question G-d, grit my teeth, put on a brave face, and give them my blessing and my permission.

On the one hand, there is about 80 percent overlap between Libertarian and Conservative political values, and in practice we tend to arrive at many similar policy positions: the rule of law, strong private property rights, freedom of contract and of association, free trade, respect for constitutional authority, low taxes, light and economically literate regulations, federalism, a government of limited and enumerated powers, frugal fiscal policies, monetary discipline, and so on.

On the other hand, Libertarians dont have much use for the Conservatives attachment to tradition. In fact, some Libertarian positions seem utterly unmoored, not just from tradition, but from reality. Take for example, the Libertarian view of migration, expressed, inter alia, in the above-cited 2016 party platform. Without any limiting principle, this position would mean the end of both nations and states. Even on the level of utopian fantasy, I dont get the appeal.

On the other hand, Libertarians advance a powerful universal moral claim that is consistent with both traditional liberal values and advanced economic thinking. Here, for example, is Alex Tabarrok, professor of economics at George Mason University, making this moral claim:

There are fundamental human rights. There are rights which accrue to everyone, no matter who they are, no matter where they are on the globe. Those rights include the right to free expression. They include the right to freedom of religion. And I believe they should also include the right to move about the Earth.

And Here is Michael Clemens, another Libertarian economist at the Center for Global Development, making the economic case:

So, you know how in real estate they say that value is all about location, location, location. Its the same for the value of your labor. And that has a remarkable implication. It means that barriers that keep you in places where youre less economically productive keep you from making the contribution you could make. And for every person whos kept in a poor country, thats a tiny little drag on the world economy that adds up. So, what that means is that even a modest relaxation of the barriers to migration that we have right now Im talking about one in 20 people who now live in poor countries being able to work in a rich country would add trillions of dollars a year to the world economy. It would add more value to the world economy than dropping all remaining barriers to trade, every tariff, every quota and dropping all remaining barriers to international investment combined.

Tabarrok again:

Its actually very simple. You take a person from a poor country, a country like Haiti for example, and you bring them to the United States or another developed country, and their wages go up.Three times, four times, fives times. Im told, sometimes as much as ten times. So, its an incredible increase in living standards simply by moving someone from where their labor has low value, moving them to where their labor has high value. Its far more effective than any other anti-poverty program weve ever tried.

There is a kind of voodoo economics quality at work here: simply exposing a person from a poor country to the spacious skies and purple mountains majesty of the United States creates a ten-fold increase in that persons welfare, and a net increase in the welfare of the world. Amazing. Are there any negative externalities associated with this transaction, multiplied millions (or billions) of times over? Neither economist tells us. If there are, presumably they are negligible, and its in poor taste to ask. (Pay no attention to Hamburg and Malm.)

On the other hand, both Tevye and his creator Sholem Aleichem were immigrants who settled in New York City. Aleichem did well there, and I have to believe that Tevye did too.

On the other hand I also believe strongly in individual rights, and I think that elevating group rights to preeminence, which is what we are doing here in the United States, is incompatible with our political traditions and notions of liberty. We will come to grief for it. But I dont see how it can be a universal individual right to live anywhere on the globe one pleases. I may be a simple barefoot Virginia country lawyer, but I am used to thinking of a right as a claim for which a duly constituted political or judicial body has the power to grant relief or redress. No such body can grant relief for the claim advanced by Professors Tabarrok and Clemens, which has little basis in custom or practice. It is a purely abstract assertion that founders on such deeply rooted legal principles as state sovereignty.

Libertarianism shares with Marxism and other bastard stepchildren of the Enlightenment this abstract ideological quality, disconnected from the realities of lived human experience. For Marxism, the fatal conceit is its obsession with equality; for Libertarians, it is hyper-individualism. Like most primates, human beings are social, hierarchical, and tribal. Hierarchical means that humans are constantly jockeying with one another for social status, and a society of perfect equality is therefore a dangerous delusion. Tribal means that we are deeply, irrationally attached to exclusive collective identities, as anyone who has ever attended an American high school or a major team sporting event can tell you. There is no escape from the tribalism, its so deeply ingrained in us. Try to suppress it, and it comes out in other forms. Dissolve the 20th century American national identity, and you get the vicious and stupid identity politics of the 21st.

It seems to me that the error at the root of social contract theory is the understanding that the basic pre-political social unit is the individual. This understanding is ahistorical and wrongheaded as a matter of anthropology and psychology. The basic pre-political social unit is the family and tribe (which is really just extended family). Being an Old World immigrant myself, as well as a member of Tevyes very ancient tribe, I am deeply sympathetic to Edmund Burkes insight that human societies have an organic character, that their members are connected to each other and to past and future generations through bonds of partnership and obligation, and arent merely fungible, interchangeable economic units. Like any partnership, this is a kind of contract, but very different from what Libertarians and liberals believe. It encompasses nationalism, for one thing, whereas those other views tend to lead to borderless one-world utopianism. Of course, from a certain point of view modern nationalism is a deliberately manufactured construct. But what makes nation states such powerful political actors, and nationalism such a potent force in international politics, is that they are both the political manifestations of, and tap into, a very deep human feature.

On the other hand, wasnt it nationalism that brought us the worst crimes and conflagrations of the 20th century?

No. Western elites learned all the wrong lessons from the 20th century. After the Second World War they came to see in the nation-statenotthe fullest political expression of peoplehood, the seat of law and legitimacy, a celebration of human variety, and the font of culture, art, and human flourishing, but rather the heart of genocide. They completely misconstrued Adam Smiths dictum that there is a great deal of ruin in a nation. The horrors of the 20thcentury were caused not by nationalism in general, but byGermannationalism in particular.

The true lesson of the 20th century is that public policy works best when it works with the grain of human nature, not against it. Perhaps overcoming our irrational tendencies is a worthy individual goal. But the road to anti-human hell is paved with attempts to eliminate them altogether. The main challenge for the modern social order is managing and moderating the more malign and destructive forms of our nature. No one said it was going to be easy.

On the other hand

No. There is no other hand.

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Tevye the Milkman, Libertarianism, and the Open Borders Fantasy - Ricochet.com

Evacuated North Carolina Islands Allowing Visitors Again After Power Back on – NBCNews.com

Customers enter the darkened Island Convenience Store in Rodanthe on Hatteras Island, N.C., on July 28. Steve Earley / AP

Kivi Leroux Miller filed a claim at the urging of her rental company, Ocracoke Island Realty, after her vacation was cut short.

"I'm trusting them because they're the ones who sold us the insurance," she said.

The travel insurance plans, marketed under the Trip Preserver brand, have a road closure provision that will likely apply, but the claims are evaluated individually, said Linda Fallon, senior vice president of Arch Insurance Group.

Customers of another rental company, Surf or Sound Realty, had the option before their visits of buying travel insurance that was underwritten by AIG. Surf or Sound issued a statement urging its customers to file claims; AIG said it's evaluating Outer Banks claims on an individual basis and has begun paying some of them.

Andrew Vessey, who spent $2,700 on a Surf or Sound rental this week, said he's filed a claim and is waiting to hear back. The Raleigh resident started a Facebook group for similarly situated renters to vent and compare notes, and it's grown to more than 800 members. Despite frustrations, his family has "some hope with the travel insurance."

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Evacuated North Carolina Islands Allowing Visitors Again After Power Back on - NBCNews.com

The real reason Hammond didn’t talk about Falkland Islands on Argentina visit… – Express.co.uk

PA

Instead the Chancellor vowed to recapture the spirit of the age when the UK was Argentinas primary trading partner as the nation moves to unshackling itself from the European Union (EU).

Philip Hammond's failure to mention the elephant in the room may have come as a surprise to critics keen to see Britains post-Brexit position cemented, but experts suggest sabre-tattling Argentinian officials have backed off from their desperate attempt to wrestle back control of the remote British Overseas Territory.

Ian Shields OBE, former RAF Group captain and international relations lecturer at Cambridge University, told Express.co.uk: Argentina is not going to launch an attack over the sovereignty of the islands.

Plus Britains military is rock solid.

Getty Images

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Surgeon Lt Gordon Brooks with wife Christine and 3-month-old daughter Helen. Britain went to war with Argentina over the Falkland Islands in 1982. The Atlantic Conveyor was hit by an Argentinian Exocet missile, and sank 90 miles north-east of Port Stanley

EPA

Argentina is not going to launch an attack over the sovereignty of the islands. Plus Britains military is rock solid

Ian Shields OBE

Hammonds visit was driven purely by economics. This will be about an exciting bilateral trade deal.

Although Mr Shields admitted Britains decision to leave the European Union (EU) has created uncertainty for islanders, he said Mr Hammond had no need to raise the issue of sovereignty with the Latin American country.

Since Britain voted to leave the bloc in June last year, Buenos Aires has attempted to steer the lead in the remote territory by the back door.

But Mr Shields, who spent four months serving on the islands, said: Obviously both sides know there is unfinished business, but right now they are going to agree to disagree until afterBrexit.

"They will agree to deal with it in time and kick it into the long grass for now."

GETTY

We are talking about highly skilled diplomats on both sides here. Argentina knows Britain wont change its position on its sovereignty.

Hammond is not going to change his position on the sovereignty of the islands.

The UK and Argentina have been embroiled in a long-running diplomatic spat over the Falkland Islands, which have been under British control since 1833.

Argentina's 1982 invasion sparked a war which left around 650 Argentine soldiers and 255 British dead.

GETTY

It ended with the surrender of the Argentine troops a few weeks later.

On Thursday, Mr Hammond met Argentinian President Mauricio Macri, and said: We can recapture the spirit of the age when the UK was Argentina's primary trading partner.

"The evidence of that time is still all around us: in your schools, in your railways, in your universities, in your football teams. There, I said it."

"Argentina offers several opportunities in different sectors like infrastructure, energy, communications, technology and other services. We expect the UK to expand its shares of investment and trade."

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The real reason Hammond didn't talk about Falkland Islands on Argentina visit... - Express.co.uk

Timeshare owners are suing the US Virgin Islands over new fee – Marketplace.org

ByAnna Boiko-Weyrauch

August 04, 2017 | 6:55 AM

The U.S. Virgin Islands in the Caribbean has turquoise waves that lap sandy beaches, musical tree frogs that fill the air with song and $2 billion in bond debt.

The territorial government faces persistent budget holes because of borrowing and deficit spending. Its bonds continually get low ratings, it is having trouble borrowing, and some say its on the road to a Puerto Rico-style fiscal crisis. So, its leaders are finding new ways to plug those holes and reassure the bond market.

As a result, some vacationers in the U.S. Virgin Islands will face a new $25-a-day fee for using a timeshare.

The island is always looking for revenues, like every other place, said Bureau of Internal Revenue chief counsel, Tamarah Parson-Smalls. The governor has sent down a five-year plan, and this is just one small portion of his plan to ensure that the territory is self-sufficient.But the new fees have provoked the ire of some island visitors.

Kathy Kuchinski of Florida said she and her husband were already thinking of dumping their week-long timeshare.

And then we heard about this extra tax, plus, you know, we still pay for airfare. We said, Forget it! she said.

The fee is officially called the Environmental/Infrastructure Impact Fee, but its not dedicated to the islands degraded environment, such as its coral reefs, or crumbling infrastructure. Instead, most of it goes to the governments general fund.

Advocates for the timeshare industry are suing.

Timeshare tourists have the same impact as any other tourist to the U.S. Virgin Islands, and therefore it is discriminatory to single out timeshare owners for this impact fee, saidRobert Clements, thevice president of regulatory affairs for the American Resort Development Association-Resort Owners' Coalition, which filed a lawsuit in federal court in May.

Timeshare owner Monica Richard of Massachusetts stays a week or two every year. Paying the fees an extra $175 a week will mean her family will cut back on charter boat trips and eating out at the islands fancy restaurants.

Or just spending money on island that we could use to support the local businesses and now its going to need to go to the government, Richard said.

Clements predicts the fee will ultimately cause tourism to decrease. But the government is undeterred, and has started to collect the money. The new fees are expected to net an extra $19 million a year.

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Timeshare owners are suing the US Virgin Islands over new fee - Marketplace.org

OBX OUTAGE: Ocracoke & Hatteras islands now open for business – WITN

OCRACOKE, N.C. (WITN) - After a week in the dark, the power switch has finally been flipped back on to Hatteras and Ocracoke islands ahead of schedule.

That means after a week without tourists, visitors are now allowed back to the southern Outer Banks.

Several hundred vehicles were parked on the north end of the Bonner Bridge waiting for the restrictions to be lifted at noon.

Cape Hatteras Electric says crews had continued to make expedited progress on creating a new above ground transmission line this week after repairs to the underground transmission line continued to experience challenges.

The North Carolina Department of Transportation Ferry Division also announced they resumed normal service to the islands. Those are the Hatteras-Ocracoke, Cedar Island-Ocracoke, and Swan-Quarter Ocracoke routes.

Since Ocracoke's evacuation order last Thursday, the ferry division says ferries carried 3,783 people and 1,485 vehicles off the island.

While both evacuation orders to each island were lifted at noon, the State of Emergency will, however, remains in effect in Hyde County due to the losses sustained by Ocracoke residents and businesses.

On Friday, there will be multiple resources available to residents on Ocracoke.

The county is beginning to build a case for restitution for residents and businesses who experienced losses.

The Hyde County manager, director of planning and economic development, and the public information officer will be at the Ocracoke Community Center at 10:00 a.m. to collect information on financial losses.

Trillium Healthcare Services will also have a mobile crisis counselor at the center beginning at 10 a.m.

A number of organizations helped the island during this crisis, from donations in time, money and resources. Thursday alone, the Bread of Life food bank distributed more than 4,000 pounds of food to residents.

Previous Story

Full power has been restored to Hatteras and Ocracoke islands, according to Cape Hatteras Electric.

CHEC says temporary generator power to customers on Hatteras Island has ended and all customers have been returned to regular power.

Both Dare and Hyde counties now say travel restrictions to the two islands will be lifted at noon on Friday.

CHEC says all electricity conservation appeals for their customers have been lifted.

Last Thursday morning a contractor building the new Bonner Bridge accidentally cut an underground transmission line that provides power to the two islands.

Some 50,000 tourists were evacuated because of the power outage and new overhead power lines had to be erected to restore power.

Previous Story

Dare County says Hatteras Island will reopen to visitors at noon tomorrow, while Hyde County is meeting at 5:00 p.m. to discuss its plans for Ocracoke Island.

In a news release, Dare County Emergency Management says the county has been assured by Cape Hatteras Electric that there will be adequate and reliable power to the entire island tomorrow.

Mandatory power restrictions for Hatteras have now been lifted so that CHEC can complete safe stabilization of the power grid.

A spokesman for Hyde County says they have not made a decision yet to lift travel restrictions to Ocracoke Island. Hyde County says it is still waiting for official word from it's power company, Tideland Electric.

Hyde County and Tideland are holding a 5 p.m. conference call.

Last Thursday morning a contractor building the new Bonner Bridge accidentally cut an underground transmission line that provides power to the two islands.

Some 50,000 tourists were evacuated because of the power outage.

Crews have been working on erecting new overhead lines that connected the broken transmission cable to the electric grid on the islands.

Previous Story

Cape Hatteras Electric Cooperative now says they believe they can have power back on to Hatteras and Ocracoke islands on Friday or Saturday.

Thursday night, crews were able to make more progress on the new overhead transmission line. All three cables were connected to the grid this morning.

CHEC says the next steps this afternoon will be to energize the line for several hours to test the cables. After that, the utility says it will begin to gradually introduce electrical load to the new line.

A construction company building the new Bonner Bridge accidentally damaged the line a week ago.

An estimated 50,000 tourists were evacuated from Ocracoke and Hatteras islands because of the outage while generators were brought in to supply power to permanent residents and businesses.

Previous Story

Utilities now say power could be restored to two islands on the Outer Banks as early as Saturday.

Tideland Electric and Cape Hatteras Electric announced the revised time frame Wednesday morning. Hyde County officials are cautiously optimistic that visitors could return to Ocracoke Island as early as Saturday.

Crews have been working on two solutions to repairing the underground transmission line that was cut last Thursday morning.

They now say the underground solution doesn't appear viable as water seeping into the trenches continues to be a problem.

The other fix, building new overhead lines to connect to existing overhead service, is proceeding. Wednesday afternoon, Cape Hatteras Electric reported that crews were installing the second of three cables needed.

Both utilities says the restoration time frame includes the testing process that must be done before the line line is energized.

A construction company building the new Bonner Bridge accidentally damaged the line.

An estimated 50,000 tourists were evacuated from Ocracoke and Hatteras islands last week.

Previous Story

Residents on Hatteras and Ocracoke Islands continue to be without power after a PCL Construction crew accidentally severed an underground power cable last Thursday.

Representatives from the Hyde County Department of Social Services will stay on the island Wednesday to meet with residents affected at the Ocracoke Community Center from 8 a.m.-4 p.m.

Residents will be able to apply for social services programs and provide information about their current situation.

This comes after a number of citizens at the local disaster recovery center said there were still a number unmet needs for families and local businesses.

A food bank is also stepping in to help residents who have been without power for the last six days.

The Bread of Life Food Bank will be open at the Ocracoke Assembly of God Church on Lighthouse Road from 9 a.m.-5 p.m. Wednesday and Thursday, or until supplies run out.

Cape Hatteras Electric Officials say they hope to have all power restored on Hatteras and Ocracoke Islands sometime between Saturday and Monday.

Cape Hatteras Electric Cooperative says crews have made great progress Tuesday and now estimate power will be restored quicker than earlier estimates. Their new time frame is four to six days.

Underground transmission repairs have had significant challenges with water continuing to seep in. However, crews continue to use a hydro-vacuum truck along with a well and pump system.

As for the above ground repairs, all of the poles are in place and anchored. Crews are beginning to install the three-phase line Tuesday night.

Now a specialized team are preparing for the intricate process of connecting the new overhead cables in two places. They'll have to be connected to the existing underground lines just before where they were severed, and they'll also have to be connected to the existing overhead lines that run the length of Hatteras Island.

Previous Story

Utilities that serve two crippled islands on the Outer Banks say they have narrowed the time frame to get power restored.

A contractor building the new Bonner Bridge cut into the underground transmission lines that serve Hatteras and Ocracoke islands on Thursday morning.

Cape Hatteras Electric and Tideland Electric now both say full power to the islands should be within six to ten days.

Crews are working on two fixes. One is to repair the existing underground cables, while a second is to build new overhead lines.

The utilities say water continues to be a problem as crews dig deeper to reach the final cable that's damaged. A well was built and a pump installed last night and Tuesday crews reached that third cable. Repairs could begin Wednesday morning..

On the overhead project, all of the poles have been set. The next step is to start installing cables for the 115 KV service.

Both islands are under mandatory evacuation orders for tourists and non-residents until power is restored.

Generators continue to provide full-time residents with electricity.

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OBX OUTAGE: Ocracoke & Hatteras islands now open for business - WITN

Saving Sinking Islands: Tamil Nadu Deploys Artificial Reefs In A First For India – Swarajya

Rising sea levels are slowly turning sinking islands into a reality, and to combat that, Tamil Nadu has come up with a novel idea to protect those islands sinking near the Gulf of Mannar deploying artificial reefs.

Indiscriminate coral mining and destructive fishing practices over the past few decades have resulted in two of the islands getting fully submerged while Vaan one of the 21 islands in the Gulf of Mannar, and a marine biodiversity park was on the verge of submergence in 2015. Its area went down from 16 hectares in 1986 to two hectares in 2014.

Between December 2015 and August 2016, the area of Vaan went up by 2.24 hectares in low tide and 1.8 hectares during mean tide. The restoration of Vaan is funded by the National Adaptation Fund for Climate Change under the Ministry of Environment, Forests and Climate Change at a cost of Rs 25 crore.

A first in India to rescue and restore sinking islands, deployment of artificial reefs parallel to the sinking island in the seaward side lessens the effect of currents and waves, thereby increasing fish habitats and protecting their diversity. Natural corals attach themselves to artificial reefs over time and the process of regeneration takes over.

Owing to the success in Vaan, Tamil Nadu has approached the Green Climate Fund for additional funding of Rs 100 crore to undertake the restoration of two more islands.

Based on wave dynamic and bathymetry studies conducted by the Indian Institute of Technology Madras (IIT M), the design of artificial reefs and locations for deployment were finalised. The concrete reefs have been deployed 250 metres from the island in a semi-circular constellation. In the first two phases, 4,600 modules have been deployed in eight months. With additional funding, the plan is to take the total number of artificial reefs to 10,000 in two layers.

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Saving Sinking Islands: Tamil Nadu Deploys Artificial Reefs In A First For India - Swarajya

Here’s where experts say we should draw the line on gene-editing experiments on human embryos – Los Angeles Times

A day after a blockbuster report that researchers had edited harmful genetic mutations out of human embryos in an Oregon lab, an international group of genetics experts urged scientists against taking the next step.

A panel of the American Society of Human Genetics, joined by representatives from 10 organizations scattered across the globe, recommended against genome editing that culminates in human pregnancy. Their views were published Thursday in the American Journal of Human Genetics.

In the United States, the Food & Drug Administration forbids any medical use of gene editing that would affect future generations, and the agency strictly regulates experimental use of the technology in labs. But around the world, scientists sometimes circumvent restrictions like these by conducting clinical work in countries that have no such strictures.

People who want to gain access to these techniques can find people willing to perform them in venues where they are able to do so, said Jeffrey Kahn, director of the Berman Center for Bioethics at Johns Hopkins University. That underscores the importance of international discussion of what norms we will follow.

Indeed, some of the groups signing on to the new consensus statement acknowledged that they inhabit parts of the world in which medical and scientific regulatory bodies scarcely exist, or are not robust.

The panel said it supports publicly funded research of the sort performed at Oregon Health & Science University and reported Wednesday in the journal Nature. Such work could facilitate research on the possible future applications of gene editing, according to its position statement.

In the Nature study, researchers created human embryos with a mutation in the MYBPC3 gene that causes an often fatal condition called inherited hypertrophic cardiomyopathy. Then they edited the DNA of those embryos during the first five days of their development. At that point, the embryos were extensively analyzed and used to create stem cell lines that can be maintained indefinitely and used for further research.

But advancing to the next step allowing pregnancies to proceed with altered embryos will require further debate, the genetics specialists asserted.

They cited persistent uncertainties regarding the safety of gene-editing techniques. They also said the ethical implications of so-called germ-line editing, which would alter a patients genetic code in ways that would affect his or her offspring, remain insufficiently considered.

Panel members raised questions about who would have access to therapies made possible by manipulating the genome, and how existing inequities could be exacerbated. And they expressed concerns that the availability of germ-line editing could encourage experiments in eugenics the creation of people engineered for qualities such as intelligence, beauty or strength that would set them apart as superior.

Perhaps the most deeply felt concern is conceptual: the sense that in identifying some individuals and their traits as unfit, we experience a collective loss of our humanity, the group wrote.

The position statement comes on the heels of the Nature study reporting the first successful use in human embryos of a relatively new and increasingly popular gene-editing technique known as CRISPR-Cas9. That study offered some reassurance that unforeseen or off target effects of such therapies can be avoided with certain practices.

Study leader Shoukhrat Mitalipov, a biologist at the Oregon university, said that while there is a long road ahead, he hoped to employ these techniques in human clinical trials in the coming years.

The genetics groups consensus statement lays out some of the scientific and ethical debates that should come before any trial would attempt the incubation and birth of children whose faulty genes had been repaired while they were still embryos.

The group also voiced concerns about the potential impact of germ-line editing on families and societies in which they might become widely used.

Arguably, the ability to easily request interventions intended to reduce medical risks and costs could make parents less tolerant of perceived imperfections or differences within their families, panel members wrote. Clinical use of germline gene editing might not be in the best interest of the affected individual if it erodes parental instinct for unconditional acceptance.

melissa.healy@latimes.com

@LATMelissaHealy

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Here's where experts say we should draw the line on gene-editing experiments on human embryos - Los Angeles Times

Genetics expert discusses creating ground rules for human germline editing – Medical Xpress

August 4, 2017

A Stanford professor of genetics discusses the thinking behind a formal policy statement endorsing the idea that researchers continue editing genes in human germ cells.

A team of genetics experts has issued a policy statement recommending that research on editing human genes in eggs, sperm and early embryos continue, provided the work does not result in a human pregnancy.

Kelly Ormond, MS, professor of genetics at the Stanford School of Medicine, is one of three lead authors of the statement, which provides a framework for regulating the editing of human germ cells. Germ cells, a tiny subset of all the cells in the body, give rise to eggs and sperm. Edits to the genes of germ cells are passed on to offspring.

The statement, published today in the American Journal of Human Genetics, was jointly prepared by the American Society for Human Genetics and four other human genetics organizations, including the National Society of Genetic Counselors, and endorsed by another six, including societies in the United Kingdom, Canada, Australia, Africa and Asia.

Germline gene editing raises a host of technical and ethical questions that, for now, remain largely unanswered. The ASHG policy statement proposes that federal funding for germline genome editing research not be prohibited; that germline editing not be done in any human embryo that would develop inside a woman; and that future clinical germline genome editing in humans not proceed without a compelling medical rationale, evidence supporting clinical use, ethical justification, and a process incorporating input from the public, patients and their families, and other stakeholders.

Ormond recently discussed the issues that prompted the statement's creation with writer Jennie Dusheck.

Q: Why did you think it was important to issue a statement now?

Ormond: Much of the interest arose a couple of years ago when a group of researchers in China did a proof of principle study demonstrating that they could edit the genes of human embryos.

The embryos weren't viable [meaning they could not lead to a baby], but I think that paper worried people. Gene editing in human germ cells is not technically easy, and it's not likely to be a top choice for correcting genetic mutations. Still, it worried us that somebody was starting to do it.

We've been able to alter genes for many years now, but the new techniques, such as CRISPR/Cas9, that have come out in the past five years have made it a lot easier, and things are moving fast. It's now quite realistic to do human germline gene editing, and some people have been calling for a moratorium on such work.

Our organization, the American Society of Human Genetics, decided that it would be important to investigate the ethical issues and put out a statement regarding germline genome editing, and what we thought should happen in the near term moving forward.

As we got into the process, we realized that this had global impact because much of the work was happening outside of the United States. And we realized that if someone, anywhere in the world, were moving forward on germline genome editing, that it was going to influence things more broadly. So we reached out to many other countries and organizations to see if we could get global buy-in to the ideas we were thinking about.

Q: Are there regulations now in place that prevent researchers from editing human embryos that could result in a pregnancy and birth?

Ormond: Regulations vary from country to country, so research that is illegal in one country could be legal in another. That's part of the challenge and why we thought it was so important to have multiple countries involved in this statement.

Also, since 1995 the United States has had regulations against federal funding for research that creates or destroys human embryos. We worry that restricting federal funding on things like germline editing will drive the research underground so there's less regulation and less transparency. We felt it was really important to say that we support federal funding for this kind of research.

Q: Is germline editing in humans useful and valuable?

Ormond: Germline editing doesn't have many immediate uses. A lot of people argue that if you're trying to prevent genetic disease (as opposed to treating it), there are many other ways to do that. We have options like prenatal testing or IVF and pre-implantation genetic testing and then selecting only those embryos that aren't affected. For the vast majority of situations, those are feasible options for parents concerned about a genetic disease.

The number of situations where you couldn't use pre-implantation genetic diagnosis to avoid having an affected child are so few and far between. For example, if a parent was what we call a homozygote for a dominant condition such as BRCA1 or Huntington's disease, or if both members of the couple were affected with the same recessive condition, like cystic fibrosis or sickle cell anemia, it wouldn't be possible to have a biologically related child that didn't carry that gene, not unless germline editing were used.

Q: What makes germline editing controversial?

Ormond: There are families out there who see germline editing as a solution to some genetic conditions. For example, during a National Academy of Sciences meeting in December of 2015, a parent stood up and said, "I have a child who has a genetic condition. Please let this move forward; this is something that could help."

But I also work in disability studies, as it relates to genetic testing, and there are many individuals who feel strongly that genetic testing or changing genes in any way makes a negative statement about them and their worth. So this topic really edges into concerns about eugenics and about what can happen once we have the ability to change our genes.

Germline gene editing impacts not just the individual whose genes are edited, but their future offspring and future generations. We need to listen to all of those voices and try to set a path that takes all of them into account.

That's a huge debate right now. A lot of people say, "Let's not mess around with the germline. Let's only edit genes after a person is born with a medical condition." Treating an existing medical condition is different from changing someone's genes from the start, in the germline, when you don't know what else you're going to influence.

Q: There was a paper recently about gene editing that caused mutations in excessive numbers of nontargeted genes, so called "off-target effects." Did that result surprise you or change anything about what you were thinking?

Ormond: I think part of the problem is that this research is moving very fast. One of our biggest challenges was that you can't do a good ethical assessment of the risks and benefits of a treatment or technology if you don't know what those risks are, and they remain unclear.

We keep learning about potential risks, including off-target mutations and other unintended consequences. Before anyone ever tries to do germline gene editing in humans, it is very important that we do animal studies where the animals are followed through multiple generations, so that we can see what happens in the long term. There's just a lot that we don't know.

There are so many unknowns that we don't even know what guidelines to set. For example, what's an appropriate new mutation level in some of these technologies? What is the risk we're willing to take as we move forward into human studies? And I think those guidelines need to be set as we move forward into clinical trials, both in somatic cells [cells of the body, such as skin cells, neurons, blood cells] and in germline cells.

It's really hard because, of course, we're talking about, for the most part, bad diseases that significantly impact quality of life. So if you're talking about a really serious disease, maybe you're willing to take more risk there, and these new mutations aren't likely to be as bad as the genetic condition you already have. But we don't know, right?

We haven't had any public dialogue about any of this, and that's what we need to have. We need to find a way to educate the public and scientists about all of these issues so people can have informed discussions and really come together as this moves forward, so that were not in that reactive place when it potentially becomes a real choice.

And that goes back to your first question, which is why did we feel like we needed to have a statement now? We wanted to get those conversations going.

Explore further: 11 organizations urge cautious but proactive approach to gene editing

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Genetics expert discusses creating ground rules for human germline editing - Medical Xpress

Ancient DNA solves mystery of fate of Bible’s Canaanites – The Columbian

A A

In the Bronze Age, between 4,000 and 3,000 years ago, a diverse group of people called the Canaanites lived in the Middle East. Despite their culture and influence one of the only golden calf idols discovered was found in the Canaan seaport of Ashqelon they left behind little information about themselves. Other civilizations made records of them, such as the Greeks, Egyptians and the authors of the Hebrew Bible. But, without Canaanite texts to cite, scholars view the ancient people as a bit of an enigma.

We havent found any of their writings, said Chris Tyler-Smith, a geneticist who studies human evolution at the Sanger Institute in Britain. Perhaps they wrote on papyrus but not longer-lasting clay. We dont have direct information from them, he said. In that sense, they are a mystery.

Their final fate, too, was a puzzle. The Hebrew text offers one explanation for the destiny of the Canaanites: annihilation. The Israelites, per Deuteronomy 20:16-18, were commanded to utterly destroy the cities of various tribes including the Canaanites. Those who survived fled or became servants.

But historians are skeptical that either exodus or annihilation occurred. University of North Carolina religious studies professor Bart Ehrman noted in a 2013 blog post that, beyond the Hebrew Bible, there are no references in any other ancient source to a massive destruction of the cities of Canaan.

Now a study of Canaanite DNA, published recently in the American Journal of Human Genetics, rules out the biblical idea that an ancient war wiped out the group. The DNA, when compared to that of modern-day people, shows that the Canaanites managed to leave a long line of descendants. Even if they suffered some defeats, enough people survived that they contributed to the present-day population, Tyler-Smith said.

Tyler-Smith and his colleagues sampled ancient DNA from five Canaanite people who lived 3,750 and 3,650 years ago. Though the skeletal remains were buried in a hot and humid region along the Mediterranean, the scientists were still able to extract genetic material. They mined the petrous bone, a region of skull behind the ear thats also the densest bone in the body.

The geneticists sequenced the Canaanite genome and compared it to genomes of modern people, including Jordanians, Palestinians, Syrians and others from around the world. The comparison revealed that 90 percent of the genetic ancestry of people in Lebanon came from the Canaanites. (The other 10 percent was of a Eurasian steppe population.)

We can say that Lebanese mostly descend from an ancestry that is found in those five individuals, said Marc Haber, a Sanger Institute geneticist and an author of the new study. What we find is that the ancestry has changed, but it has changed very little.

The unbroken genetic heritage was a surprise. From the Bronze Age onward, that coastal Mediterranean region has been the site of repeated conquering and reshuffling of populations. There was more genetic continuity in Lebanon than in a place like England, Tyler-Smith said.

Its an exciting time to be investigating ancient DNA, the geneticists said. The Canaanites were an ideal case study ancient genomes can provide information not available through historical records or archaeology. But the corridor from Egypt to Asia was a path well-worn by many groups moving in and out of Africa.

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Ancient DNA solves mystery of fate of Bible's Canaanites - The Columbian

After Health Care Collapse, GOP Seeks Redemption With Tax Cuts – NPR

Senate Majority Leader Mitch McConnell, R-Ky., joined by fellow Senate Republicans, holds a news conference on Capitol Hill on Tuesday, Aug. 1, 2017. J. Scott Applewhite/AP hide caption

Senate Majority Leader Mitch McConnell, R-Ky., joined by fellow Senate Republicans, holds a news conference on Capitol Hill on Tuesday, Aug. 1, 2017.

The White House says the fight over health care is not over, but on Capitol Hill, Republicans are ready to move on.

"The president isn't giving up on health care and neither should the Senate," Office of Management and Budget Director Mick Mulvaney declared on CNN on Wednesday.

On the Senate floor that same morning, Senate Majority Leader Mitch McConnell, of Kentucky, was already focused elsewhere.

"Comprehensive tax reform represents the single most important action we can take now to grow the economy and help middle-class families get ahead," McConnell said. He added that the Republican Party has a "once-in-a-generation opportunity" to redesign the nation's tax laws.

McConnell has not publicly declared the Republican effort to "repeal and replace" the Affordable Care Act over, but the mood on Capitol Hill has decidedly shifted to the next legislative battle: cutting taxes.

The same day the health care bill collapsed last week, the "Big Six" negotiators announced a very broad outline of what Republicans hope to achieve with a tax overhaul.

"The goal is a plan that reduces tax rates as much as possible," read a statement by McConnell, House Speaker Paul Ryan, House Ways and Means Committee Chairman Kevin Brady, R-Texas, Senate Finance Committee Chairman Orrin Hatch, R-Utah, Treasury Secretary Steven Mnuchin, and National Economic Council Director Gary Cohn.

The group has been meeting privately for months to sketch out a game plan on tax legislation. Those meetings also ultimately scuttled Ryan's original hopes of including a controversial new tax on imports that he had hoped would raise new revenue to pay for cuts elsewhere.

Republicans are hopeful that a tax bill will be an easier lift than health care, and lawmakers say the pressure to deliver tax legislation has intensified after failing on long-promised health care legislation.

While the party never really coalesced around an alternative to the Affordable Care Act, every Republican in Congress supports tax cuts.

Some of the broad proposals include reducing the number of personal income tax brackets, and lowering the corporate rate as low as 15 percent which the president has called for in the past.

The tough questions about what those rates will be, if or how tax cuts will be paid for and what process Republicans will use to get the legislation through Congress remain unanswered.

The last major federal tax overhaul of this scale was in 1986, under President Reagan, who signed a bipartisan bill that has become a tale of Washington folklore featuring, for example, a final deal worked out over two pitchers of beer at a Capitol Hill pub.

But, the prospect of a bipartisan bill this time fizzled quickly earlier this week.

Forty-five Senate Democrats sent a letter to McConnell outlining the conditions that needed to be met for them to work with Republicans on a tax bill: no tax cuts for the wealthiest Americans and no cuts to entitlement programs to pay for tax cuts.

McConnell quickly declared that offer a non-starter, and indicated Republicans will use the same budget reconciliation process they deployed on health care to skirt the Senate filibuster and try to pass a bill with 51 votes.

Democrats are skeptical Republicans can pull that off with a tax overhaul.

"The question will be: Are they going to repeat the mistake of health care where they said they want to try to do tax reform just with Republicans?" said Sen. Mark Warner, D-Va., "If they use reconciliation they're not going to have a very easy path. If they think health care is hard, they have not seen anything in terms of how you deal with the complexity of tax reform."

The White House is demanding an aggressive schedule. Mnuchin this week said Trump would like to sign a bill by Thanksgiving.

Congressional Republicans are using the August recess to drum up support for their ideas, including an event at the Reagan Ranch in California on Aug. 16.

The Senate wrapped up its pre-recess business Thursday. So both chambers are on August recess until after Labor Day.

Already, staff is working on draft legislation. House and Senate lawmakers say they hope to release those drafts in September and start having open committee hearings.

Under this timeline, the House would vote in October, and the Senate would follow suit in November and send the bill to the president.

"This won't be an easy process, but the people we represent are depending on us for help. Now is the time to deliver tax reform, and I look forward to working with my colleagues to accomplish it," McConnell said.

Whether or not Republicans can pass a tax bill and whether or not their voters will forgive them for not passing a health care bill are two questions that will hang over the GOP majority for the rest of 2017.

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After Health Care Collapse, GOP Seeks Redemption With Tax Cuts - NPR

Collins, Murkowski take CNN behind the scenes of the health care battle – CNN

But as Republican Sens. Susan Collins and Lisa Murkowski sat side-by-side in an exclusive joint interview with CNN's Dana Bash on Thursday, they steadfastly stood by their decisions to buck their own party's recent push on health care.

The two women reflected on last week's turbulent series of events and their votes that ultimately led to the suspenseful downfall of Republican efforts to repeal and replace the Affordable Care Act.

"It's always hard not to be a member of the team. There's lots of pressure to do that," said Collins, a four-term senator from Maine. "But in the end, I have to do what I think is right. And that's what I did in this case."

Ticking off a list of the pressures senators face -- "repercussion from party, a tweet from the President, backlash from your leadership" -- Murkowski, a three-term senator from Alaska, argued that she and her colleagues shouldn't have to feel "motivated or discouraged" from doing what they feel is right for their respective states.

Murkowski knows firsthand the impact of a tweet from the President. A day after she and Collins were the only two senators to oppose a procedural vote on health care last week, President Donald Trump fired off a tweet singling out Murkowski, saying she "really let the Republicans, and our country, down."

The senator said that tweet also came a day after the President personally spoke to her over the phone. Asked if she felt intimidated by their conversations, Murkowski declined to get specific. "I will just say that the President and I had a very direct call."

She also received a call from Interior Secretary Ryan Zinke, a person who holds enormous sway in a state like Alaska, to urge Murkowski to support the President on health care.

Zinke is now being investigated by the department's inspector general over whether the secretary threatened Alaska's economic development in the phone call. Responding to news of the preliminary probe, Murkowski told Bash that she did not interpret the phone call as a "threat" but that "he was merely delivering a message."

Pressed on whether Zinke mentioned economic development in the call, Murkowski simply stated the focus was on health care. "What he mentioned was that the President was very -- that the health care bill was very important to the President," she said.

Before last week's health care votes, Murkowski had been warning Trump that she was not going to vote by party line on the issue. Earlier last month at the White House, at a meeting between Republican senators and Trump on health care, Murkowski said she told the President in front her colleagues that she wasn't necessarily going to back whatever Republicans ended up proposing. "I am voting for the people of Alaska," she said.

"Lisa gave a wonderful speech that day at the White House," Collins added, with her colleague sitting next to her. "And I remembered being so proud of you for saying directly to the President what your obligations were."

Both women felt that one of those obligations was protecting federal funds for Planned Parenthood during the health care battle, saying too many women in their states relied on it for health care needs like cancer screenings. Collins said she felt it was "inconsistent with our Republican ideals" to advocate for people to choose their own health care providers -- but not if it was Planned Parenthood.

Just three days after Murkowski and Collins were the only two Republicans to oppose a procedural vote to move on to a health care measure -- resulting in Vice President Mike Pence having to make the tie-breaking vote -- the two were back in the "no" column again, but this time they had company.

Sen. John McCain joined the two women to vote against what was dubbed the "skinny repeal" bill to strip away key aspects of the Affordable Care Act -- essentially a last-resort option for Senate Republicans after other measures failed to advance. While very few senators were particularly thrilled about the legislation, they were hoping to at least pass it, then work with the House to improve it in a conference committee.

But it wasn't good enough for Collins and Murkowski, and in a dramatic twist, McCain became the third Republican senator to vote no, effectively sinking the bill. They said they didn't know for sure how he was going to vote until he walked up to them on the floor after midnight at the late-night vote.

"I so remember when both Lisa and I were talking with John McCain on the Senate floor and he pointed to both of us and he said, you two are right on this issue," she said. "And that's when I knew for sure."

Murkowski said she'll never forget a conversation the three had after the vote.

"He said people might not appreciate what has happened right now as being a positive," she recalled. "But time will prove that having a pause, having time out for us to do better is going to be good for the country. And it was a good, good, strong John McCain message."

Just a few days later, Republican Sen. Jeff Flake of Arizona, a longtime critic of Trump's, released a scathing critique of the President in his book, arguing that his party was in "denial" and urging others to stand up to the White House.

Asked by Bash if there was a noticeable shift in the way Republicans were starting to handle Trump, Collins said that many in her party are still interested in the President's agenda but are not so tolerant of his style.

"I don't think that the caucus is ignoring the President," Collins said. "But there may be some ignoring of his rhetoric, which, at times, is over the top."

Murkowski agreed, saying that when the rhetoric from the Oval Office "is not constructive to governing," it's "important to speak up."

"And I think you are starting to see a little bit of that," she added. "I think we're all still getting to know this new administration and how this President operates."

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Collins, Murkowski take CNN behind the scenes of the health care battle - CNN

The Health 202: Here’s why John McCain voted ‘no’ on health care – Washington Post

THE PROGNOSIS

John McCains surprise, middle-of-the-night thumb down that sunk his partys Obamacare repeal bill last week made for perfect political showbiz. But signals the Arizona Republican would be the final GOP defector were there all along. After all, McCains a mostly free spirit from a state that deeply benefited from the Affordable Care Act. And he likes some drama now and again.

McCains never really belonged to the brand of tea party-style Republicans who loved to rail against Obamacare. He criticized the ACA when he needed to, like when he was running for reelection in 2010 and again last year. But McCain didnt share many of his colleagues perspective that virtually anything would be better than President Obamas health-care law.

Besides, McCain is used to ducking the party line on other issues, too, like campaign finance reform and climate change.

Theres a certain impulsiveness about McCain, and every once in a while he tends to stray from orthodoxy, David Berman, a political science professor at Arizona State University, told me.

If there were ever a time for McCain to stray from orthodoxy and do whatever he wants, its now. Just a few days before the Senatevote on its "skinny repeal" bill, the 80-year-oldannounced he has glioblastoma, a common but aggressive form of brain cancer.

So while McCain sees the same realities back home as Arizonas other senator, Republican Jeff Flake, the two parted ways on Obamacare partly because they are facing far different political situations. McCain, in all likelihood, never has to worry about another election, while Flake is facing a potentially tough reelection race next year.

Speaking of those realities back home, theyre harsh.

Arizona is among the handful of Republican-led states that expanded Medicaid to cover low-income, childless adults. That program, along with new opportunities for coverage through federally subsidized marketplace plans, has provided coverage tohalf a million Arizonansover the past few years. Arizonas uninsured rate fell from 17.3 percent in 2009 to 10.8 in 2015 the 13th-largest drop in the nation during that time.

Arizona, with its expanding retiree population, has also seen its health-care sector explode in recent years. Since 2010 it has experienced the fifth-highest health-care job growth of any state, according to the U.S. Bureau of Labor Statistics.

So it was a no-go for McCain when Senate leadership pressured him to support skinny repeal that would have destabilized insurance markets without fixing Obamacares deepest problems and could have led to a return of deep Medicaid cuts proposed in the Senates replacement bill known as the Better Care Reconciliation Act. State officials had estimated that the BCRA would have cost Arizonas Medicaid program $7.1 billion by the end of 2026.

Arizona was about to get screwed, if I may, under this plan,"McCain toldPhoenix-based radio host Mike Broomhead yesterday.

Thats exactly what Arizona Gov. Doug Ducey was privately worried about, although as a Republican hed also publicly criticized Obamacare, at times calling it "ground zero" for problems with the law. Three amendments McCain offered to protect Arizona, including one to phase out Medicaid expansion over a decade instead of the seven years envisioned by the BCRA, were at the behest of Ducey. McCain said all along he would center his health-care vote on Ducey's wishes:

McCains no vote has won him praise among health-care advocates in Arizona. I think people are pretty pleased with him in the world I work in, Greg Vigdor, president of the Arizona Hospital and Healthcare Association, told The Health 202.

But McCain wasnt just frustrated by the GOP legislation itself hed also expressed annoyance all along at the Senate GOP leaderships secretive process in writing it, at times even mocking the lack of transparency.

Damned if I know,McCain responded in May when I asked whether he expects a health-care vote this summer.

Look at the concernsMcCaintweeted over the past several weeks:

Business Insiders Bob Bryan noted McCain's skepticism at the Senate's initial repeal-and-replace bill, the Better Care Reconciliation Act (BCRA):

Ultimately, I think a lot of it comes down to the unique nature of Sen. McCain as a person and a legislator, Vigdor said. He really believes in the Senate as the great bastion of debate and deliberate consideration.

McCain displayed that love for Senate procedure and regular order in a floor speech he gave on July 25, his first time in the chamber since announcing his cancer diagnosis. In that speech, which Democrats being cut out of the health-care process especially hailed, McCain in strong terms blasted GOP leadership for trying to cram through an unpopular Obamacare repeal measure and called in his party to start reaching across the aisle.

Weve tried to do this by coming up with a proposal behind closed doors in consultation with the administration, then springing it on skeptical members, trying to convince them its better than nothing, asking us to swallow our doubts and force it past a unified opposition," McCain said."I dont think that is going to work in the end."

Boston Globe's Matt Visernoted Democratic leader Chuck Schumer's response to McCain's speech:

Of course McCain, who lost to President Obama in 2008, doesnt eschew the limelight, either. Reporters hounded him last week afterhe emerged as one of the chief GOP skeptics of the repeal effort. As he walked into the Senate chamber around 1 a.m. on July 28for the skinny repeal vote, he played coy amid the flood of questions about which way he leaned.

Watch the show, McCain told reporters.

He'd warned he'd vote against a repeal-replace bill if it wasn't improved....and then he did, noted HuffPost's Matt Fuller:

MSNBC's Lawrence O'Donnell:

Programming note:The Health 202 will not publish on Monday, Aug.7 and on Friday, Aug.11 next week. Well be back in your inbox on Tuesday. In the meantime, be sure to read our colleague Tory Newmyers The Finance 202 every day next week.

AHH, OOF and OUCH

Interior SecretaryRyan Zinke testifies during aSenate Energy and Natural Resources Committee hearing. (EPA/MICHAEL REYNOLDS)

AHH: What better way to mend fences than over a couple of beers? Interior Secretary Ryan Zinkesays he's patched things up withAlaska Sen. Lisa Murkowski (R) after a widely reported dispute over hervote last week against starting the health-care debate, according to the AP.

Zinke had reportedly called Murkowskito threaten repercussions for Alaskaif she failed to toe the administration's line on health care. But yesterday Zinketweeted to his nearly 50,000 followers a photo of himself and Murkowskienjoying Alaskan beers at his Washington home:

Murkowski, who leads the Senate Energy and Natural Resources Committee, was one of two Republicans to vote against starting health-care debate (along with Sen. Susan Collins of Maine) and joined both Colins and McCain to ultimately vote against the "skinny repeal" bill.

OOF: Maybe the Senate's embarrassing failure to pass Obamacare repeal was a blessing in disguise for Republicans. A new poll taken in the days just after the Senate failed to pass a series of different optionsfinds staggering oppositiontoward the GOP effort. Eighty percent of registered voters in a Quinnipiac University poll -- including 60 percent of self-identified Republicans -- said they disapproved of the way Republicans were handling health care. Just one-fourth of respondents said they were in favor of alternative health-care legislation presented by the Senate.

House Speaker Paul Ryanspeaks about health-care at hisweekly press conference. REUTERS/Yuri Gripas TPX IMAGES OF THE DAY

OUCH: Wait for it, wait for it. Here it is: The House GOP health-care defense is "maybe the Senate didn't manage to pass Obamacare repeal but thank goodness we did." That's essentially how Speaker Paul D. Ryan (R-Wis.P) responded to constituents yesterday, when they blasted congressional Republicans for getting little done this year even though they control both houses of Congressand the White House.

For eight horrible years I heard we dont have control of the House, we dont have control of the Senate, we dont have the presidency, Banker Wire employee Keith Ketzler, 62, said to Ryan, according to the AP. Ill tell you what, youre in there now and all I see is in-fighting. Its very dysfunctional. I dont see any plans for anything.

Ryan said he's worried too -- and noted that the House did pass a health-care bill in May.

I can make sure that the House delivers," Ryan said. I dont run the Senate, I run the House.

TRUMP TEMPERATURE

President Trumplistens as West Virginia Gov. Jim Justice speaks at a campaign-style rally at Big Sandy Superstore Arena in Huntington.(AP Photo/Susan Walsh)

--New Hampshire is notorious for its drug-abuse problems. But Trumpdidn't do himself any political favors by depicting the entire state as one big "drugden" in s phone call withMexican PresidentEnrique Pea Nietosix days after his inauguration. I won New Hampshire because New Hampshire is a drug-infested den, Trump told Nieto in a phone callon Jan. 27. The call was private, but The Post's Greg Millerobtained the transcript plus an equally eyebrow-raising one of a call with Australian Prime Minister Malcolm Turnbull.

There area few things that could come back to haunt Trumppolitically based on that one sentence, The Post's Amber Phillips writes. For one thing, Trump ticked off New Hampshire's two senators and its Democratic organization:

From New Hampshire Maggie Hassan (D):

From the New Hampshire Democratic Party:

The state's Republican governor, Chris Sununu, also denounced the drug commentdespite previously standing by Trump in sticky campaign situations. PerMSNBCs Shirley Zilberstein:

Some pushback to the criticism from New Hampshire Republicans:

HEALTH ON THE HILL

Senate Majority Leader Mitch McConnelltalks with reporters.(Photo by Chip Somodevilla/Getty Images)

--August recess has officially commenced, and The Health 202 couldn't be happier. But this is not how Senate Majority Leader MItch McConnell (R-Ky.) wanted to head into the long summer break, which has turnedinto the perfect storm against hisbest-laid plans. My colleague Paul Kane has the must-read take:

"Soon after Memorial Day, McConnell drew up a game plan around approving a rewrite of the Affordable Care Act by the end of June. The benefits were twofold, providing House Republicans a few weeks to approve the Senate version and send it to President Trump," Paul writes. "Also, McConnell wanted to create separation between the conclusion of the health-care debate and the start of the annual August recess, providing the month of July to rack up victories on other legislative matters. Such wins would give some Senate Republicans, wary of tackling the health-care issue back home, something else to tout with their voters."

Instead, everything got consumed by the health-care storm, which culminated in the bill failing by a single vote last week. Then yesterday, the Senate left town for a five-week breakwith no major legislative accomplishments to show for the first seven months of unified Republican control of Congress and the White House.

"When they return after Labor Day, Republicans have to tackle several must-pass bills to fund federal agencies and to increase the Treasurys borrowing authority. Those are perfunctory tasks, but without the proper tending, failure would result in government shutdowns or worse. That leaves October, maybe, for the point to legislative offense, particularly on the bid to overhaul the tax code....This is the scenario McConnell was trying to avoid back in early June."

A few more good reads from The Post and beyond:

Without fanfare or controversy, the Senate approved legislation that will keep many FDAoperations running and deliver a win to the pharmaceutical industry.

The measure is broader than some state laws, because it covers patients with serious but not imminently deadly conditions, such as muscular dystrophy.

President Donald Trump announced new efforts Thursday to use technology to improve veterans health care, saying the programs will greatly expand access, especially for mental health care and suicide prevention. Veterans living in rural areas will also benefit, he said.

Darlene Superville|AP

Dr. Jerome Adams, Trumps nominee for surgeon general, tried to make a distinction between guns and gun violence during his confirmation hearing.

STAT News

SECOND OPINION

We're not the same as antiabortion Republicans. Really.

Kristen Day

DAYBOOK

(AP Photo/Pablo Martinez Monsivais)

SUGAR RUSH

President Trump introduces new telehealth initiative for veterans:

Trump: 'Veterans means so much for me and this administration':

What Trumps golfing habits say about him:

Stephen Colbert wants to serve on Robert Muellers grand jury:

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The Health 202: Here's why John McCain voted 'no' on health care - Washington Post

Ohio National Guard, health departments hosting free healthcare event in Madison Co. – NBC4i.com

LONDON, OH (WCMH) The Ohio National Guard along with the Ohio Department of Health and Madison County Public Health is hosting a free healthcare event Saturday.

GuardCare offers free healthcare services to anyone who attends, regardless of income and insurance is not needed or considered.

No appointment is necessary to attend and care provided will include immunizations, sports physicals, womens health services, and hearing and vision testing.

GuardCare is hosted each year in a different medically-underserved Ohio community.

The event is being held Saturday from 8am to 5pm at London High School, 336 Elm Street.

Through GuardCare, Ohio National Guard medical personnel support and assist local health care providers. The event also enhances the medical skills of Ohio National Guard medical personnel, many of whom work as health care professionals in their civilian occupations as well.

NBC4i.com provides commenting to allow for constructive discussion on the stories we cover. In order to comment here, you acknowledge you have read and agreed to our Terms of Service. Commenters who violate these terms, including use of vulgar language or racial slurs, will be banned. Please be respectful of the opinions of others and keep the conversation on topic and civil. If you see an inappropriate comment, please flag it for our moderators to review.

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Ohio National Guard, health departments hosting free healthcare event in Madison Co. - NBC4i.com

Let’s Stop the Bickering and Fix the Health Care System – New York Times

Our plan would stabilize markets by making the cost-sharing payments mandatory and thereby prevent rates from rising sharply.

Second, we provide a relief valve to help states deal with the high cost of pre-existing and chronic conditions. The costliest 5 percent of patients account for nearly half of all health care spending in the country. We propose a dedicated stability fund essentially a form of reinsurance that states could use to reduce premiums and limit losses for providing coverage for these high-cost patients.

Third, our proposal provides relief to certain businesses from the mandate that they provide insurance to full-time employees. It also defines full time as a 40-hour workweek to discourage businesses from manipulating employees weekly hours to skirt the mandate. More than 90 percent of large businesses offered health care before the Affordable Care Act, and studies show that they would continue to do so under this change; others would move to find employee coverage in the individual marketplace.

Fourth, our plan eliminates the Medical Device Tax, an excise charge of 2.3 percent that is often passed onto consumers and reduces funds for research and development. And finally, we provide states with additional flexibility to enter into agreements such as enabling the sale of insurance across state lines that would provide more choice and lower costs.

This proposal would not increase the federal deficit, offering several options to offset the new spending.

Our plan isnt intended to rectify everything thats wrong with American health care. We aim to solve an immediate problem and move past a seven-year stalemate in Washington that has featured Republicans trying to repeal the current health care law, Democrats trying to preserve it and neither side willing to discuss anything in between.

That approach has led us to our current moment, in which no one is happy with the status quo, least of all the American people, whose trust and confidence in Washington weakens every day that we spend fighting instead of solving real problems.

Health care is one of those problems and a textbook example of why we formed the Problem Solvers Caucus this year. We all knew the partisanship in Washington had gotten out of control and felt the need to create a bipartisan group committed to getting to yes on important issues. We have agreed to vote together for any policy proposal that garners the support of 75 percent of the entire Problem Solvers Caucus, as well as 51 percent of both the Democrats and Republicans in the caucus.

If Washington does not act to stabilize the insurance exchanges, many families we represent will lose coverage or be hit with premiums they cant afford. This isnt conjecture.

If that does happen, people will be justifiably livid that Republicans and Democrats in Congress did nothing to stop a train wreck we all saw coming.

There is a growing recognition on Capitol Hill that something must be done, as evidenced by this weeks announcement from Senator Lamar Alexander the Tennessee Republican who is chairman of the Senate Health, Education, Labor and Pensions Committee that he will soon hold hearings focused on repairing the individual insurance market.

Our proposal isnt perfect, but it represents the first and only serious bipartisan health care proposal released in this Congress. We hope our colleagues in the House and Senate, as well as the White House, will use our plan as the foundation for the health care solution that America desperately needs and deserves.

Josh Gottheimer is a Democratic representative from New Jersey. Tom Reed is a Republican representative from New York.

Follow The New York Times Opinion section on Facebook and Twitter (@NYTopinion), and sign up for the Opinion Today newsletter.

A version of this op-ed appears in print on August 4, 2017, on Page A23 of the New York edition with the headline: A Bipartisan Fix for Health Care.

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Let's Stop the Bickering and Fix the Health Care System - New York Times

VA announces expansion of ‘anywhere to anywhere’ health care services – FederalNewsRadio.com

In partnership with the White House Office of American Innovation, the Veterans Affairs Department announced anexpansion of its telehealth services or anywhere to anywhere health care.

The departmentwill issue a joint regulation with the Office of American Innovation and Justice Department to allow all VA providers to administer telehealth services to veterans anywhere in the country.

Existing telehealth programs provided care to more than 700,000 veterans last year and covered at least 50 different specialties, from dentistry to dermatology.

Were removing regulations that have prevented us from doing this, VA Secretary David Shulkin said during aAug. 3 White House announcement. Were removing geography as a barrier so that we can speed up access to veterans and really honor our commitment to them.

Download our free ebook to find out how agency CIOs and CHCOs implementing the president's reorganization executive order.

President Donald Trump, who watched Shulkin and other VA doctors demonstratea live interaction with a veteran patient using video,said the program will help VA expand access to care across the country, particularly in rural locations and for veterans who need mental health care.

That means were going to be able to use VA providers in cities where there are a lot of doctors, and be able to use those doctors to help our veterans in rural areas where there arent many health care professionals, Shulkin said. And you talked about mental health and suicide prevention; this is one of those areas that we can really use that expertise.

Shulkin this year named suicide prevention as his top clinical priority. He also recently announced an expansion of VA mental health services to veterans who received a less than honorable discharge from service.

To help them administer the telehealth program, the department will roll out VA Video Connect to providers nationwide. Currently, about 300 VA providers use it at 67 hospitals and clinics.

Video Connect lets VA providers use their mobile devices to see and speak with veterans on their own mobile devices or home computers.

Shulkin, a doctor himself who still sees veterans, spoke with one of his patients in Grants Pass, Oregon, through the video screen.

SEC warns TSP participants of new scam

The department will also roll outits Veterans Appointment Request (VAR) application nationwide. The app lets veterans schedule, change or cancel their own appointments with VA providers on their own time. VA currently has the app working in 18 regions but plans to expand it to the rest of the country.

The VAR app is different from the departments attempts to update its own, in-house appointment scheduling system.

The department is evaluating a commercial scheduling solution, theMedical Appointment Scheduling System (MASS) to replace the aging system VA has now.

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VA announces expansion of 'anywhere to anywhere' health care services - FederalNewsRadio.com

Madhuri Hegde, PhD is Elected to the Board of the ACMG Foundation for Genetic and Genomic Medicine – PR Newswire (press release)

Dr. Hegde joined PerkinElmer in 2016 as Vice President and Chief Scientific Officer, Global Genetics Laboratory Services. She also is an Adjunct Professor of Human Genetics in the Department of Human Genetics at Emory University. Previously, Dr. Hegde was Executive Director and Chief Scientific Officer at Emory Genetics Laboratory in Atlanta, GA and Professor of Human Genetics and Pediatrics at Emory University and Assistant Professor, Department of Human Genetics and Senior Director at Baylor College of Medicine in Houston, TX.

Dr. Hegde has served on a number of Scientific Advisory Boards for patient advocacy groups including Parent Project Muscular Dystrophy, Congenital Muscular Dystrophy and Neuromuscular Disease Foundation. She was a Board member of the Association for Molecular Pathology and received the Outstanding Faculty Award from MD Anderson Cancer Center. She earned her PhD in Applied Biology from the University of Auckland in Auckland, New Zealand and completed her Postdoctoral Fellowship in Molecular Genetics at Baylor College of Medicine in Houston, TX. She also holds a Master of Science in Microbiology from the University of Mumbai in India. She has authored more than 100 peer-reviewed publications and has given more than 100 keynote and invited presentations at major national and internal conferences.

"We are delighted that Dr. Hegde has been elected to the ACMG Foundation Board of Directors. She has vast experience in genetic and genomic testing and is a longtime member of the College and supporter of both the College and the Foundation," said Bruce R. Korf, MD, PhD, FACMG, president of the ACMG Foundation.

The complete list of the ACMG Foundation board of directors is at http://www.acmgfoundation.org.

About the ACMG Foundation for Genetic and Genomic Medicine

The ACMG Foundation for Genetic and Genomic Medicine, a 501(c)(3) nonprofit organization, is a community of supporters and contributors who understand the importance of medical genetics and genomics in healthcare. Established in 1992, the ACMG Foundation for Genetic and Genomic Medicine supports the American College of Medical Genetics and Genomics' mission to "translate genes into health" by raising funds to help train the next generation of medical geneticists, to sponsor the development of practice guidelines, to promote information about medical genetics, and much more.

To learn more about the important mission and projects of the ACMG Foundation for Genetic and Genomic Medicine and how you too can support the work of the Foundation, please visit http://www.acmgfoundation.org or contact us at acmgf@acmgfoundation.org or 301-718-2014.

Contact Kathy Beal, MBA ACMG Media Relations, kbeal@acmg.net

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SOURCE American College of Medical Genetics and Genomics

http://www.acmg.net

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Madhuri Hegde, PhD is Elected to the Board of the ACMG Foundation for Genetic and Genomic Medicine - PR Newswire (press release)

11 Organizations Urge Caution, Not Ban, on CRISPR Germline Genome Editing – Genetic Engineering & Biotechnology News (press release)

Unintended Effects

In a statement to Catholic News Agency earlier this week, Rev.Tadeusz Pacholczyk, Ph.D., director of education for the National Catholic Bioethics Center, expressed moral objection to germline genome editing on embryos: Their value as human beings is profoundly denigrated every time they are created, experimented upon, and then killed. Moreover, if such embryos were to grow up, as will doubtless occur in the future, there are likely to be unintended effects from modifying their genes.

The 11 organizations acknowledged numerous ethical issues arising from human germline genome editing, including:

At a minimum, the potential for harm to individuals and families, ramifications on which we can only speculate, provide a strong argument for prudence and further research, the policy statement asserted. By proceeding with caution, we can ensure better understanding of the potential risks and benefits of gene editing from a scientific perspective and, as such, provide families with a more fulsome exercise of their autonomous decision making through the consent process.

The statement added: We encourage ethical and social consideration in tandem with basic science research in the upcoming years.

Last October, You Lu, M.D., and colleagues at Sichuan Universitys West China Hospital in Chengdu launched the first known clinical trial using CRISPR to treat patientsspecifically, knocking out a gene encoding the programmed death protein 1 (PD-1) in patients with non-small-cell lung cancer.

Groups joining ASHG in issuing the policy statement included the Association of Genetic Nurses and Counsellors, the Canadian Association of Genetic Counsellors, the International Genetic Epidemiology Society, and the National Society of Genetic Counselors.

Additional groups authoring the policy statement were the American Society for Reproductive Medicine, the Asia Pacific Society of Human Genetics, the British Society for Genetic Medicine, the Human Genetics Society of Australasia, the Professional Society of Genetic Counselors in Asia, and the Southern African Society for Human Genetics.

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11 Organizations Urge Caution, Not Ban, on CRISPR Germline Genome Editing - Genetic Engineering & Biotechnology News (press release)

Genetic risk for lupus tied to ancestry – Medical Xpress

August 4, 2017 by Will Doss Credit: CC0 Public Domain

Northwestern Medicine collaborated with international colleagues in a study that identified two dozen new genes linked to lupus after analyzing genetic samples from over 27,000 individuals across the globe.

The study, published in Nature Communications, was co-authored by Rosalind Ramsey-Goldman, MD, DrPH, the Solovy/Arthritis Research Society Research Professor of Medicine in the Division of Rheumatology, part of a group of authors from more than 70 universities.

"These new observations will help direct future research to better diagnose and treat the disease while also providing insights into why lupus disproportionately affects certain ethnicities at higher rates and more severely," said Ramsey-Goldman, also a member of the Robert H. Lurie Comprehensive Center Cancer and Northwestern University Clinical and Translational Sciences Institute.

Systemic lupus erythematosus (SLE) is an autoimmune disease that predominantly affects women during their childbearing years, and is more common in African-American, Native American and Hispanic patients. In SLE, the immune system produces antibodies that cause inflammation and damage the body's own organs and tissues, but it can be difficult to diagnose because its symptoms are similar to those of other immune system diseases.

The study revealed 24 genomic regions that contribute to an accelerating pattern of risk for SLE, leading the investigators to propose what they call the "cumulative hit hypothesis."

According to the authors, an immune system can normally absorb the effect of a modest amount of these risky genes, but as the number of genes climbs the immune system becomes overwhelmedresulting in disorders such as SLE.

The ancestral distribution of these genes may explain the ethnic disparities in SLE, according to the study. One cluster of risky genes has a greater frequency in people with African-American ancestry, a population with a higher incidence of SLE. On the other hand, a different risky cluster was less common in those with a mix of African-American and Central European ancestry, reflecting how a complex demographic history can affect the risk of developing SLE.

"There is a genetic predisposition to developing lupus and this study will help scientists decipher the heterogeneous manifestations of the disease, which is hard to diagnose and treat," Ramsey-Goldman said. "The hope is that these discoveries lead to better diagnostic tools, such as biomarkers, and assist in the development of targeted therapies."

While large-scale population screening may not be financially practical, it may be more realistic to accelerate the diagnosis of suspected lupus by testing narrowly for genetic markers such as those uncovered in the current study, according to the authors.

"Understanding the implications and not just cataloguing the overlap of genetic variation that predicts multiple autoimmune diseases is a key next set of questions these investigators are pursuing," said lead author Carl Langefeld, PhD, professor of Biostatistics at Wake Forest Medicine.

Explore further: Large multi-ethnic study identifies many new genetic markers for lupus

More information: Carl D. Langefeld et al. Transancestral mapping and genetic load in systemic lupus erythematosus, Nature Communications (2017). DOI: 10.1038/ncomms16021

Leading rheumatologist and Feinstein Institute for Medical Research Professor Betty Diamond, MD, may have identified a protein as a cause for the adverse reaction of the immune system in patients suffering from lupus. A better ...

A new study by researchers from Brigham and Women's Hospital in Boston, Massachusetts reveals that Asian and Hispanic patients with systemic lupus erythematosus (SLE) have lower mortality rates compared to Black, White, or ...

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Genetic risk for lupus tied to ancestry - Medical Xpress

A Blueprint for Genetically Engineering a Super Coral – Smithsonian

In a healthy reef, coral symbionts make food for the coral animal.

A coral reef takes thousands of years to build, yet can vanish in an instant.

The culprit is usuallycoral bleaching, a disease exacerbated by warming watersthat today threatens reefs around the globe. The worst recorded bleaching eventstruck the South Pacific between 2014 and 2016, when rising ocean temperatures followed by a sudden influx of warm El Nio waters traumatizedthe Great Barrier Reef.In just one seasonbleaching decimated nearly a quarter of thevast ecosystem, which once sprawled nearly 150,000 square miles through the Coral Sea.

As awful as it was, that bleaching event was a wake-up call, says Rachel Levin, a molecular biologist who recently proposed a bold technique to save these key ecosystems. Her idea, published in the journal Frontiers in Microbiology, is simple:Rather than finding healthy symbiontsto repopulate bleached coral in nature, engineer them in the lab instead.Given that this would requiretampering with nature in a significant way, the proposal is likely to stir controversial waters.

But Levin argues that with time running out for reefs worldwide, the potential value could wellbe worth the risk.

Levin studied cancer pharmacology as an undergraduate, but became fascinated by the threats facing aquatic life while dabbling in marine science courses. She was struck by the fact that, unlike in human disease research, there were far fewer researchers fighting to restore ocean health. After she graduated, she moved from California to Sydney, Australia to pursue a Ph.D. at the Center for Marine Bio-Innovation in the University of New South Wales, with the hope of applying her expertise in human disease research to corals.

In medicine, it often takes the threat of a serious disease for researchers to try a new and controversial treatment (i.e. merging two womens healthy eggs with one mans sperm to make a three-parent baby).The same holds in environmental scienceto an extent.Like a terrible disease [in] humans, when people realize how dire the situation is becoming researchers start trying to propose much more, Levin says.When it comes to saving the environment, however, there are fewer advocates willing to implementrisky, groundbreaking techniques.

When it comes to reefscrucial marine regions that harbor an astonishing amount of diversity as well as protect land massesfrom storm surges, floods and erosionthat hesitation could be fatal.

Coral bleachingis often presented as the death of coral, which is a little misleading. Actually, its the breakdown of the symbiotic union that enables a coral to thrive. The coral animal itself is like a building developer who constructs the scaffolding of a high rise apartment complex. The developer rents out each of the billions of rooms to single-celled, photosynthetic microbes called Symbiodinium.

But in this case, in exchange for a safe place to live, Symbiodinium makes food for the coral using photosynthesis. A bleached coral, by contrast, is like a deserted building. With no tenants to make their meals, the coral eventually dies.

Though bleaching can be deadly, its actually a clever evolutionary strategy of the coral. The Symbiodinium are expected to uphold their end of the bargain. But when the water gets too warm, they stop photosynthesizing. When that food goes scarce, the coral sends an eviction notice. Its like having a bad tenantyoure going to get rid of what you have and see if you can find better, Levin says.

But as the oceans continue to warm, its harder and harder to find good tenants. That means evictions can be risky. In a warming ocean, the coral animal might die before it can find any better rentersa scenario that has decimated reef ecosystems around the planet.

Levin wanted to solve this problem,by creatinga straightforward recipe for building a super-symbiont that could repopulate bleached corals and help them to persist through climate changeessentially, the perfect tenants. But she had to start small. At the time, there were so many holes and gaps that prevented us from going forward, she says. All I wanted to do was show that we could genetically engineer [Symbiodinium].

Even that would prove to be a tall order. The first challenge was that, despite being a single-celled organism, Symbiodinium has an unwieldy genome. Usually symbiotic organisms have streamlined genomes, since they rely on their hosts for most of their needs. Yet while other species have genomes of around 2 million base pairs, Symbiodiniums genome is 3 orders of magnitude larger.

Theyre humongous, Levin says. In fact, the entire human genome is only slightly less than 3 times as big as Symbiodiniums.

Even after advances in DNA sequencing made deciphering these genomes possible, scientists still had no idea what 80 percent of the genes were for. We needed to backtrack and piece together which gene was doing what in this organism, Levin says. A member of a group of phytoplankton called dinoflagellates, Symbiodinium are incredibly diverse. Levin turned her attention to two key Symbiodinium strains she could grow in her lab.

The first strain, like most Symbiodinium, was vulnerable to the high temperatures that cause coral bleaching. Turn up the heat dial a few notches, and this critter was toast. But the other strain, which had been isolated from the rare corals that live in the warmest environments,seemed to be impervious to heat. If she could figure out how these two strains wielded their genes during bleaching conditions, then she might find the genetic keys to engineering a new super-strain.

When Levin turned up the heat, she saw that the hardySymbiodinium escalated its production of antioxidants and heat shock proteins, which help repair cellular damage caused by heat. Unsurprisingly, the normal Symbiodinium didnt. Levin then turned her attention to figuring out a way to insert more copies of these crucial heat tolerating genes into the weaker Symbiodinium, thereby creating a strain adapted to live with corals from temperate regionsbut with the tools to survive warming oceans.

Getting new DNA into a dinoflagellate cell is no easy task. While tiny, these cells are protected by armored plates, two cell membranes, and a cell wall. You can get through if you push hard enough, Levin says. But then again, you might end up killing the cells. So Levin solicited help from an unlikely collaborator: a virus. After all, viruses have evolved to be able to put their genes into their hosts genomethats how they survive and reproduce, she says.

Levin isolated a virus that infected Symbiodinium, and molecularly altered it it so that it no longer killed the cells. Instead, she engineered it to be a benign delivery system for those heat tolerating genes. In her paper, Levin argues that the viruss payload could use CRISPR, the breakthrough gene editing technique that relies on a natural process used by bacteria, to cut and paste those extra genes into a region of the Symbiodiniums genome where they would be highly expressed.

It sounds straightforward enough. But messing with a living ecosystem is never simple, says says Dustin Kemp, professor of biology at the University of Alabama at Birmingham who studies the ecological impacts of climate change on coral reefs. Im very much in favor of these solutions to conserve and genetically help, says Kemp. But rebuilding reefs that have taken thousands of years to form is going to be a very daunting task.

Considering the staggering diversity of the Symbiodinium strains that live within just one coral species, even if there was a robust system for genetic modification, Kemp wonders if it would ever be possible to engineer enough different super-Symbiodinium to restore that diversity. If you clear cut an old growth forest and then go out and plant a few pine trees, is that really saving or rebuilding the forest? asks Kemp, who was not involved with the study.

But Kemp agrees that reefs are dying at an alarming rate, too fast for the natural evolution of Symbiodinium to keep up. If corals were rapidly evolving to handle [warming waters], youd think we would have seen it by now, he says.

Thomas Mock, a marine microbiologist at the University of East Anglia in the UKand a pioneer in genetically modifying phytoplankton, also points out that dinoflagellate biology is still largely enshrouded in mystery. To me this is messing around, he says. But this is how it starts usually. Provocative argument is always goodits very very challenging, but lets get started somewhere and see what we can achieve. Recently, CSIRO, the Australian governments science division, has announced that it will fund laboratories to continue researching genetic modifications in coral symbionts.

When it comes to human healthfor instance, protecting humans from devastating diseases like malaria or Zikascientists have been willing to try more drastic techniques, such as releasing mosquitoes genetically programmed to pass on lethal genes. The genetic modifications needed to save corals, Levin argues, would not be nearly as extreme. She adds that much more controlled lab testing is required before genetically modified Symbiodinium could be released into the environment to repopulate dying corals reefs.

When were talking genetically engineered, were not significantly altering these species, she says. Were not making hugely mutant things. All were trying to do is give them an extra copy of a gene they already have to help them out ... were not trying to be crazy scientists.

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A Blueprint for Genetically Engineering a Super Coral - Smithsonian

Genetic Engineering with ‘Strict Guidelines?’ Ha! – National Review

Human genetic engineering is moving forward exponentially and we are still not having any meaningful societal, regulatory, or legislative conversations about whether, how, and to what extent we should permit the human genome to be altered in ways that flow down the generations.

But dont worry. The scientists assure us, when that can be done, there will (somehow) beSTRICT OVERSIGHT From the AP story:

And lots more research is needed to tell if its really safe, added Britains Lovell-Badge. He and Kahn were part of a National Academy of Sciences report earlier this year that said if germline editing ever were allowed, it should be only for serious diseases with no good alternatives and done with strict oversight.

Please!No more! When I laugh this hard it makes mystomach hurt.

Heres the problem: Strict guidelines rarely are strict and the almost never permanently protect. Theyare ignored, unenforced, or stretched over time until they, essentially, cease to exist.

Thats awful with actions such as euthanasia. But wecant let that kind of pretense rule the day withtechnologies that could prove to be among themost powerful and potentially destructive inventions in human history. Indeed, other than nuclear weapons, I cant think of a technology with more destructive potential.

Strict oversight will have to include legal limitations and clear boundaries, enforced bystiff criminalpenalties, civil remedies, and international protocols.

They wont be easy to craft and it will take significant time to work through all of the scientific and ethical conundrums.

But we havent made a beginning. If we wait until what may be able to be done actually can be done, it will be too late.

Wheres the leadership? All we have now is drift.

Link:

Genetic Engineering with 'Strict Guidelines?' Ha! - National Review