Can Science Answer All the Big Questions? – Discovery Institute

Oxford chemist Peter Atkins is an indefatigable atheist. He is as much of a fanatic as any of the New (mostly old, actually) Atheists. He was on the receiving end of perhaps the most devastating debate retort Ive ever seen in 1998 at the hands of William Lane Craig (the fun really begins at about a minute into the clip).

After Craigs reply to Atkinss bizarre claim that science holds all answers, one would have thought that Atkins would slink away in embarrassment. But no. Atkins has written a recent essay for Aeon: Why its only science that can answer all the big questions. Its standard atheist boilerplate theres no evidence for God, questions about meaning of existence and about the soul are a waste of time, religious belief is wishful thinking, religion is violent, and so on. Its just cut-and-paste atheist twaddle of the kind you might expect from a not-too-bright college sophomore in a state that just legalized marijuana.

Atkins is wrong, of course, as Craig pointed out with such stunning clarity. Many of the most important disciplines logic and mathematics, metaphysical truths, ethics and moral law, aesthetic judgements, and even basic axioms of science itself are not scientific questions and cannot be answered by scientific methods. Even the very arguments that atheists like Atkins employ are not scientific issues. The claim that science is the only way to answer all the big questions is itself not a scientific claim it is an epistemological claim. The assertion that science can answer all questions is self-refuting. The assertion itself is not science.

But we theists should not make the mistake of abandoning science to Atkins et al. In a restricted sense, Atkins is right about the power of the scientific method. Science is a remarkably effective way to answer many questions about existence. The problem for Atkins is that science provides powerful evidence for the existence of God. Heres why.

There are three ways we can know something about reality. We can perceive it with our senses the coffee cup on the table in front of us, for example. Or we can infer something by a priori logical reasoning. Much of mathematics is like this.

The third way is by a posteriori reasoning, which is inferential reasoning. A posteriori reasoning follows this pattern: we collect evidence about things that exist, and via a logical or mathematical process of reasoning we infer a truth about existence. This is the scientific method. This is also natural theology, which is the branch of theology that proves Gods existence using evidence and reason. It is distinguished from revealed theology, which deals with truths about God that are known from Scripture, tradition, etc.

Natural theology is science. It is exactly the same kind of knowing that is used routinely in natural science. For example, consider our scientific knowledge about the Big Bang. We collect evidence (the red shift, cosmic background radiation, etc.), and by a process of reason and logic (Einsteins general relativity, etc.) we conclude that the universe began as a singularity 14 billion years ago. Its good science solid a posteriori reasoning.

Now consider one of the many strong proofs of Gods existence Aquinas Second Way. We collect evidence (the fact that there are chains of essentially ordered causes in the universe), and by a process of reason and logic (the metaphysics of potency and act and Aristotles Law of the Excluded Middle) we conclude that the universe has an Uncaused Cause, which all men call God. Its also good science solid a posteriori reasoning.

And it wont do to object, as atheists commonly do, that inference to God cannot be drawn from evidence in the natural world because God is supernatural. After all, the singularity of the Big Bang is supernatural, in the very real sense that it is undefined in the natural world. Science infers all manner of supernatural (or extra-natural) things logic, mathematics, the laws of physics, etc., which are not tangible objects in the natural world. Yet they are very real and science uses them and points to them.

If you look carefully, the scientific evidence for God is much stronger than the evidence for the Big Bang or for any commonly accepted scientific theory. The evidence employed in the First Cause argument is the fact that change occurs in nature, which is undeniable, and the logical process that follows is recognition of the nature of potentiality and actuality and the impossibility of something existing and not existing in the same way at the same time. From this undeniable evidence and solid logic we infer that a First Cause exists. The a posteriori reasoning behind the scientific evidence for Gods existence is much stronger much more compelling scientific evidence than the evidence for any other theory in natural science.

We on the reality-based side of this debate must not cede science to the atheists. Atkins is right that science can answer some of the biggest questions we can ask, such as Does God exist? Atkinss problem is that he doesnt like the answer science provides: using the ordinary methods of a posteriori inference essential to the scientific method, scientific evidence and logic clearly demonstrate the existence of God.

Photo: Mystic Mountain, in the Carina Nebula, via NASA, ESA, M. Livio and the Hubble 20th Anniversary Team (STScI).

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Can Science Answer All the Big Questions? - Discovery Institute

Captain Marvel Might Be Leading Two Superhero Teams in Future MCU Films – Fatherly

With the conclusion of the Infinity Saga and the exits of Tony Stark and Steve Rogers, the Marvel Cinematic Universe has more question marks than its had in years. And with a dearth of real information, rumors are flying about whats in store for the future of the franchise.

The latest tantalizing piece of potential information concerns Captain Marvel. Showbiz CheatSheet, citing current narrative projections in the MCU and leaks from Marvel insiders, reports that in addition to the long-rumored A-Force, Captain Marvel is the natural choice to lead another rumored superhero team: The Ultimates.

Marvel head Kevin Feige has said that Captain Marvel will be a core piece of the puzzle moving forward, and leading both the all-female A-Force and the mixed-gender Ultimates would certainly make that a promise kept.

The A-Force came to be in a short-lived comic series published in 2015 and 2016. It includes Captain Marvel, Medusa, She-Hulk, Singularity, Nico Minoru, and Dazzler Thor.

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She-Hulk is coming to her own Disney+ series. Jane Foster is taking on the mantle of Mighty Thor inThor: Love and Thunder. It would make sense to put Captain Marvel, a character played by an Oscar winner who already has a solo Marvel film under her belt, at the head of the team of characters whove already debuted in the MCU.

Like the A-Force, The Ultimates was also a limited comic book series published in the early aughts. It currently counts Black Panther, Ms. America (who will reportedly appear in a Disney+ show), Spectrum (who appeared inCaptain Marvel), and Blue Marvel as members. With the exception of the latter, an Ultimates movie would have the same advantage of featuring characters who already exist in the MCU.

It also seems likely that Marvel wants to get Captain Marvel and Black Panther on screen together, and an Ultimates movie would be a relatively easy way to do so.

Alas, however, these are just rumors, and whats at least as likely as an elaborate secret plan already being hatched is that Feige and company are still making decisions about the future.

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Leyla Blue is one of the most exciting new voices in pop [Interview] – EARMILK

20-year old New York based artist Leyla Blue released her first EP this past November.The 3-track EP titled "Songs For Boys That Didn't Text Me Back" is concise yet full of emotional and powerful range. Blue is the biggest 90s/2000s R&B/pop fan: "I use the term bad bitch/sad bitch to describe it. So it's this idea that only through owning your sad bitch do you actually become a bad bitch."

Blue also grew up in New York City. To grow up in a city like New York, it's impossible to not be influenced by the inherent everyday hustle that the people embody. This is a city with such infamous and unique notoriety - there's a feeling that encompasses every corner, where you simply look around and it's dreamer after dreamer working really hard to make it happen. Blue is so consciously aware of the city's direct impact on her, she says "I think that growing up in a place where hustle and belief in yourself is normal, when I was a 13 year old who just decided on a weekend that she wants to be a singer, yes it seemed crazy - but it seemed somehow not out of this world. Growing up in New York I think is what made me believe in myself."

The singularity of Blue is in her ability to balance the power of her voice with raw and honest emotion. It's that thing that you can't fake, when an artist honestly makes you feel their pain, their joy, and their experiences - they're instantly in a different domain of artistry. One of Blue's favorite artists and influences is Amy Winehouse. She says "Her lyrics are really where she shines, in the sense that they're so personal and so confessional and just gut-wrenching." That soul combined with confessional and personal lyricism, and then bringing it into the pop-sphere is an extraordinary ability and talent that Amy Winehouse was able to showcase in her music. Similarly, Blue is well on her way to mastering that same significant balance.

"Peppa Pig" is Blue's first release of 2020 and her first release since her debut EP "Songs For Boys That Didn't Text Me Back". Produced by Y2K, Leyla definitely taps into a different side to herself on "Peppa Pig" - more of her "bad bitch" side. She is an artist that treats her music like her diary, with different moods and feelings expressed. "Peppa Pig" is an ode to that feeling that you can't really describe other than just saying "Bitch I feel like Peppa Pig".

There's such a fun bounce to the production - so on coming together with Y2K and making the track, Blue says: "Peppa Pig is just my absolute most carefree, feeling like a bad b*tch so I'm going to make a song that makes me feel like a stupid 5 year old bad b*tch. Y2K and I - we had coffee and we realized we had absolutely opposite tastes in music. We were like ok let's see what comes out of this. We got in the studio with my co-writer Jesse and we just started talking and watching weird 'Peppa Pig' videos, we ordered Mexican food and literally made the song in 3 hours (laughs). The vocals that you hear on there, have not changed since that night."

Blue has some new visuals and more music coming soon (she's aiming for a second EP release by early summer). She talks about the new music she's working on and says "This EP is the most personal stuff I've ever written. It's literally my brain, heart and soul in a body of work. It's basically like ok now that I've left this party and I've finally gotten over this guy, now I'm stuck with myself."

Her debut NYC show is on February 4th at The Slipper Room.For someone with such a powerful voice, it's exciting to see what her live performance would look like. "For me, a live show is really where I get to showcase how every song is a different chapter of my book and I get to show the whole book and tell the stories behind the songs - and how this is not just a random group of songs and made on Spotify." Blue's future is looking bright, as she continues to work on her craft: "I hope to be able to speak to as many lonely 13 year olds in their bedroom as possible because that's exactly what I needed. Me discovering music when I was 13 literally saved my life, I just hope to do that for as many people as possible."

Connect with Leyla Blue: Instagram | Youtube | Soundcloud

Originally posted here:

Leyla Blue is one of the most exciting new voices in pop [Interview] - EARMILK

Find ways to improve the revenue of farmers: Congress – The Hindu

Prime Minister Narendra Modi government should implement a minimum income guarantee scheme to boost rural consumption, on the lines of what his party had promised before the 2019 Lok Sabha elections, and a national farm loan waiver to tackle rural distress, the Congress said on Wednesday.

Addressing a press conference as part of the Congresss special series on the Union Budget, former Maharashtra Chief Minister Prithviraj Chavan asked the union government to spell out its measures to double farm incomes by 2022.

Mr. Chavan demanded reduction in Goods and Services Tax (GST) rates on agriculture inputs to less than 5% and said the government should announce measures like universal basic income to put more money in the hands of farmers and the poor so that their consumption increases.

The party demanded that petrol and diesel be brought under the GST regime. He said the Centre had earned over 13.5 lakh crore by way of taxes on petroleum products in the past five years.

We demand that the government should put more money in the hands of 95% of the poor who live in rural areas and help improve consumption through schemes like MNREGA. The government should also bring a universal basic income scheme to ensure that there is direct benefit to people and money should go into their accounts directly to help improve consumption levels, Mr. Chavan said.

The Congress leader also raised serious questions about the Centres procurement policy, minimum support price, functioning of the Food Corporation of India (FCI) and the crop insurance scheme. I want to give some figures. In 2019-20, the total amount disbursed as compensation to Kharif crops is 153 crore, while the premium collected by the insurance companies is to the tune of 25,853 crore, he said.

Mr. Chavan said that for the farmers income to double by 2022, the agriculture sector would have to see a compound growth rate of at least 12% annually, while it was only growing at 2.9%.

How will Indias dream of becoming a $5 trillion economy be accomplished, Mr. Chavan asked and asserted that Indias official data had now come under the global scanner for its credibility. There is a lot of jugglery of figures going on and, therefore, the credibility of India is being questioned, he alleged.

Mr. Chavan also said the Centre was in default when it came to paying the States share of taxes and claimed that the union government owes 15,000 crore to Maharashtra alone.

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Find ways to improve the revenue of farmers: Congress - The Hindu

Andrew Yang Expects ‘Many’ of His Supporters to Back Sanders in Iowa: We ‘Have a Lot of Overlap’ – Newsweek

Andrew Yang told an Iowa roundtable of reporters Wednesday that he would not be surprised if his supporters went over to Senator Bernie Sanders' camp during the Iowa caucus.

While a Monmouth University poll released Wednesday showed Senator Sanders in a virtual tie with former Vice President Joe Biden, with 21 and 23 percent respectively, Yang only garnered 3 percent of the poll.

"I think that Bernie and I do have a lot of overlap in support so it wouldn't be surprising to me if many of our supporters head in that direction," Yang said.

"I frankly think I'd have a hard time getting them to do anything that they're not naturally inclined to do," Yang said of his supporters. "I think most people are going to show up on Caucus Night with a few top choices in mind and I imagine if I'm not viable at their caucus that they know exactly who they're going to go to."

Iowa's caucus is structured in such a way that candidates must receive 15 percent of the vote. Any candidate who does not hit that benchmark must throw their support to a candidate who did receive at least 15 percent of the vote or align themselves with a non-viable candidate in order to boost that candidate's final ranking.

Yang said that the campaigns of other presidential candidates have asked him for his support.

"I think some campaigns have reached out to our team," Yang said. "My team will sort out what the heck is being conveyed."

Newsweek reached out to Yang's campaign for comment but did not receive a response in time for publication.

Like Sanders, Yang's campaign platform presents some progressive policies. Yang is a proponent of Medicare for All and an aggressive stance on combating climate change.

Sanders has been critical of Yang's proposal of a universal basic income which would give every American adult $1,000 per month. Yang's basic universal income would allegedly be paid for by the implementation of a value added tax of 10 percent. That tax would be levied on "the production of goods or services a business produces," according to Yang's website.

"We take a very different approach from Mr. Yang and that is I believe in a jobs guarantee," Sanders told The Hill in August 2019. "There is an enormous amount of work that has to be done all the way from child care to health care to education to rebuilding our infrastructure to combating climate change to dealing with our growing elderly population."

Part of Sanders' jobs guarantee would depend on the enactment of the Green New Deal, which would allegedly help rebuild the U.S. infrastructure and build a new energy system that would be 100 percent sustainable.

Yang's climate change plan calls for moving away from fossil fuels and creating a 100 percent emissions-free electric grid for the country by the year 2035. His proposals also aim for a methane recapture rate of 85 percent, the activation of new nuclear reactors and passing a "constitutional amendment that creates a duty on the federal and state governments to be stewards for the environment," said his website.

Continued here:

Andrew Yang Expects 'Many' of His Supporters to Back Sanders in Iowa: We 'Have a Lot of Overlap' - Newsweek

Eliminating Child Poverty With a Government Check – The New York Times

INVISIBLE AMERICANS The Tragic Cost of Child PovertyBy Jeff Madrick

Its a paradox of American childhood poverty that experts routinely devise the most complex solutions for it or in recent parlance innovations most of which are elaborate, costly or otherwise impractical to implement.

Jeff Madrick is an exception to this rule. In his new book, Invisible Americans: The Tragic Cost of Child Poverty, he argues for a solution for children so simple that even a child could understand it: Give poor families money for their kids. In clear, spare prose, he lays out a proposal for something akin to a basic income guarantee for parents of children under 18. Poor children have many requirements, but above all they need money, he writes. He returns to this point repeatedly: Child poverty is too punishing and harmful to wait years for results especially when cash distributions can help today.

Madricks idea is essentially a subset of universal basic income, a concept championed by an increasing number of prominent Americans from the presidential candidate Andrew Yang to the conservative social scientist Charles Murray and the Facebook co-founder Chris Hughes. Madrick, a veteran journalist and economic analyst, imagines a government-funded allowance to families that would equal $4,000 to $5,000 per child each year. Every family with children would get some money, which would avoid the problem of only offering the stipend to the guardians of poor youth. After all, there are millions of near poor and struggling middle-class families as well, trying to pay for their kids out of stagnant incomes. (According to current guidelines, a family of four living on $25,750 or less qualifies as poor; realistically, Madrick argues, the number should be closer to $50,000.) In addition, he would have the allowance ladled out according to a principle of non-paternalism; in other words, it would be unconditional, like love.

If you are now crying Lets do it! consider this caveat: Naysayers would be legion. Theyd range from bootstrappers who insist a monthly dividend would discourage even decent people from working to those who harbor a more realistic fear that corporations would exploit a governmental allowance for children so they could continue to underpay employees who are parents. Madrick concedes these points, writing, Direct cash aid is denigrated by both the left and the right as a waste and inducement to laziness and abuse.

Nevertheless, the staggering number of American children who are destitute 17.5 percent and the even larger fraction who are near poor, should induce us to stop squabbling and to see the issue as a moral tragedy demanding a direct response.

With welcome brevity, Invisible Americans stitches together much of what the lay reader needs to know about American child poverty. It offers a mini-history of organizing and social programs, and of punitive attitudes toward the poor. This last includes moralizing about mothers needing more discipline and blaming a culture of poverty rather than structural failures. Madrick also throws shade on our bipartisan obsession with refunding the taxes of our poorer citizens rather than just giving them and their families money. The earned-income tax credit, he rightfully gripes, has been mostly designed to get poor parents to work.

Reading Invisible Americans, I did sometimes want to get closer to the inner and outer lives of Americas poorest families. While Madrick briefly sprinkles in a few tales of individual penury, several marked by their subjects shame and lingering physical pain of one adult who was raised too poor to afford dentistry, he writes, His mouth still hurts we dont get to know any of these people well.

But Madrick does not aspire to narrative journalism here. He is more interested in informed indignation. The reason for his outrage is clear: Ending childhood destitution was a political centerpiece of the Great Society, yet now it is rarely mentioned, especially by politicians. If our leaders absorbed this books urgent call, perhaps they would discuss poverty and act to ease it once again.

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Eliminating Child Poverty With a Government Check - The New York Times

Trump to let states overhaul Medicaid for the poor, seeking to change Obamacare without legislation – Washington Examiner

The Trump administration released guidelines Thursday for letting states accept a limited amount of money to cover poor people in exchange for flexibility in spending the funds.

The program, commonly known as a "block grant," is an approach long favored by conservatives for limiting spending on Medicaid, which pays for healthcare for poor and vulnerable people. Democrats, however, criticize the idea as stripping healthcare benefits from needy people.

Thursday's move is the latest example of Trump administration efforts to overhaul Obamacare after the Republican-controlled Senate failed to pass legislation to do so in 2017.

Joe Grogan, director of the Domestic Policy Council, said in a phone call with reporters Thursday that Seema Verma, who runs the Medicaid program, had worked "vigorously" to change Medicaid absent of congressional action. The administration is framing the move as one that will "protect and strengthen" Medicaid.

The Trump administration is calling the program "Healthy Adult Opportunity," and it's expected to face legal hurdles. Under the current Medicaid structure, the federal government matches a majority of what states pay for Medicaid every year. The change proposed by the Trump administration would mean the federal government gives states a set amount of money each year instead.

The plan applies only to the Medicaid expansion population that gained coverage under Obamacare. Before Obamacare, states varied in who got Medicaid, but the program generally went toward pregnant women, people with disabilities, and the elderly. Those groups still get Medicaid now, but the program added low-income people as well, who qualify if they make less than roughly $17,000 a year.

Conservative lawmakers have opposed the Obamacare expansion of Medicaid, saying that the program should pay for healthcare for the most vulnerable, and alleviate massively long wait lists in states for people with disabilities who are seeking housing and community care. Fourteen states have not expanded Medicaid, in part because of this philosophical difference, but also as a political stance to oppose former President Barack Obama's healthcare law.

States that participate in the program will need to regularly report back to the federal government to show how beneficiaries are doing. They would not be allowed to limit Medicaid enrollment but would have to stick to the Obamacare income rules.

Under the guidelines released Thursday, states would be allowed to exclude certain types of prescription drugs or ask patients to try cheaper versions before moving to more expensive ones, but they must continue to cover all drugs for mental health and HIV. The current Medicaid program requires that all drugs be covered, so the move would put Medicaid more in line with private health insurance practices.

Critics, including Democrats, say block grants amount to cuts to the program. They also have warned that states may incur costs that they don't expect, including if a high-cost drug hits the market or in the case of a natural disaster.

Todays announcement is the cruelest step yet by the Trump administration to slash American healthcare and dismantle basic safety net programs like Medicaid, said Sen. Ron Wyden, an Oregon Democrat.

Tennessee, Oklahoma, and Alaska are among the states that have considered the block grant trade-off. States wouldn't be able to change right away but would need to apply for the program and then go through an approval process with the federal government. Once states get the funds, however, they wouldn't have to apply for as many changes when deciding how Medicaid dollars are spent.

Under the current structure, federal officials have a lot of say about how states spend Medicaid dollars since the federal government covers the majority of costs. State officials have complained that Medicaid is inflexible and doesn't allow them to meet the various needs of their residents. Every time officials want to make a change to the program, such as letting more people receive substance abuse treatment, they have to go through a long application process with the federal government.

States have complained that filing waivers is cumbersome, involving piles of paperwork and months of work with no guarantee of approval. It can involve top officials from the Department of Health and Human Services and the Office of Management and Budget, as well as state officials and governors.

In the phone call with reporters Thursday, Verma said the administration's latest move was also intended to help Medicaid become more sustainable.

"Medicaid is the first or second budget item for states, crowding out other priorities such as transportation and education," Verma said.

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Trump to let states overhaul Medicaid for the poor, seeking to change Obamacare without legislation - Washington Examiner

The Five Best Local Songs of January 2020 – Phoenix New Times

The Valley's music scene is always moving and churning at its own unique pace, with bands and artists continuously putting out new music, from thoughtful pop-rock to jagged lo-fi noise.

We've collected some of their more recent offerings that continue to define and perpetuate our fair city. Now turn 'em way up.

Commiserate"Grain of Sand"

This "emo-wave-try"band out of central Phoenix have been going strong since late 2017, releasing an excellent self-titled EP and gigging across the Valley and beyond. What's most appealing about Commiserate is their ceaseless curiosity that constantly pushes the outfit in new and more daring directions. Case in point: their single "Grain of Sand." The track is a hazy surf-pop ditty that features a 12-person chorus. You could describe the song as a collaboration between Polyphonic Spree and The Beach Boys, but even that explanation misses out on the sheer joy and earnestness this song exudes. Next time you're cruising down a lazy river, spin this breezy ballad pronto.

Audrey Heartburn "Siren Song"

In just a few years, Audrey Heartburn have released an impressive sampling of songs and EPs, including last spring's Round 2: Fight!, which isbest described as "sonic Lucas powder."More recently, they've returned with another great single in "Siren Song." Although the band have nailed the hyper-power-pop formula, this tune feels a little more understated, a blend of Pat Benatar's pop ferociousness and The Trucks' indie angst channeled into an earnest four-minute gem. And while past efforts hinted at more "playful" subject matter, they're tackling slightly headier ideas of heartache and separation with equal measures grace and nuance. If you need to be in your feelings, this one can take you all the way down.

Treasure MammaL"The Ballad of Mr. Bonkers"

Anyone who's seen Treasure MammaL over the last decade-plus will know to expect the unexpected (and then some). But even their latest single seems a little left-field: a cover of The Aquabats' "The Ballad of Mr. Bonkers," released late last year on the 20th anniversary covers album commemorating The Floating Eye of Death. Aquabats' original is weird even for those ska superheroes, a slow-moving spaghetti-western-meets-lounge-rock ballad that's nonetheless silly and saccharine. In the hands of Abe Gil and company, the song transforms into a delightfully ethereal '80s Kraftwerk jam if that band were fronted by a bargain bin Siri-inspired A.I. Now, it's not exactly the most enthusiastic cover ever, but it earns high marks for sheer weirdness.

Holy Fawn"Tethered"

In mid-January, local dark rockers Holy Fawn returned with a surprise three-song EP, The Black Moon.With more electronics and tape textures than previous releases, the band described it as "a little different, but it's still who we are." Maybe that's what led to "Tethered." Less than three minutes in length, it doesn't quite feel like a full song, just a slow saunter of light atmospherics and gentle keys. But in that brief span, something beautiful unfurls, and your ears can't help but saunter through the soundscape. Just when things pick up, everything drops out and leaves the listener churning for a moment or two.

Soft Shoulder"Thin Red Straw (High Tension)"

Hailing from Tempe, Soft Shoulder describe themselves as "post-punk/no-wave/junk-kraut," which may invite just as many new questions than answers. If you're trying to get to know this trio, then you need only devote four minutes listening to "Thin Red Straw (High Tension)." If you believe the band, this single (part of a 7-inch with "Wellness Line") was born from the spontaneity of a haphazard "studio" session. But there's a bit of control displayed here, and the band found an intriguing way to marry post-punk grit, no-wave nihilism, and the haunting drone of krautrock. Does such skill take away from the song's sense of chaos and deeply disturbing vibes? No, it does not. Just please listen to this one away from small children and animals.

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The Five Best Local Songs of January 2020 - Phoenix New Times

BWW Review: BE HERE NOW at Everyman Theatre – A Touching Dramady About Happiness and Laughter – Broadway World

If I said one should come to the Everyman Theatre and see a play that deals with Geschwind Syndrome you may want to pass or even google it. But do not be put off by this. Just relax and see a play that deals with it. I never heard of this Syndrome and it truly does not make a difference if you know about it beforehand or after you see it. What you will see is an individual who has fainting spells due to temporal lobe epilepsy which results in sexual behavioral disorders.

Now to the play which begins with "Bari" (played by the incomparable Beth Hylton who directed this play last year at Everyman's Salon reading) laughing her way during a boring yoga class with two of her fellow employees Patty (Katy Carkuff) and Luanne (Shubhangi Kuchibhotla). The three of them work in a workplace where they pack Tchotchkes from Tibet for shipment after they cut off "Made in China" labels. 'Patty" and "Luanne" seem to love their jobs while "Bari" is bored to death.

"Bari" is also on a deadline to write her long overdue thesis on "Nihilism" which rejects all religious and moral principles in the belief that life is meaningless. She has lost her job as a professor in New York City due to her inability to complete her dissertation and returns home to hometown 100 miles north of New York to wrap gifts. Do not let this put you off. This is a comedy remember.

Everything changes when "Patty" fixes "Bari" up with a relative, "Mike" (Kyle Prue who returns to the Everyman boards after a 9-year hiatus, thankfully).

"Mike" arrives for the blind date riding his bike and wearing a helmet and oh does he have a story. He had a wonderful job, made lots of money, had a lovely home, a wife and child and one day has an auto accident where his wife and child die. He also causes the death of others and decides to give all of his possessions to the victims of his negligence, lives in a small cabin with his pet crow named Hubble, collects all sorts of garbage and items thrown away which he uses to make homes. "Bari" can't believe he received a MacArthur Grant for this great recycling. Thus, money is no object.

"BarI" is subject to headache-related seizures. Her friends at her job witnessed these as did "Mike". She refuses an ambulance. But soon, she changes completely. Suddenly she longs for affection and sex.

She realizes she has a choice. Take care of the seizures by removing a tumor and go back to her simple boring life or deal with the seizures and the joy it brought.

The playwright explains the origins of her play: "BE HERE NOW is about the search for joy, against all odds. I came across a podcast of someone talking about having Geschwind syndrome. She said she was generally a depressive person and for the first time in her life she was finding joy and meaning in life. Then she learned she had to have it (the tumor) removed. She did have it removed and regretted it, regretted losing that, like mourned that joy for the rest of her life, so I thought "Oh, this is definitely a play."

As one can easily see, there is a lot here to understand but if one just goes along with the flow, you will thoroughly enjoy it.

It is worth it alone to see Beth Hylton's magnificent performance. It's as if the play was written for her! Prue is simply superb as the rest of the cast.

Set Designer once again deserves kudos for his terrific set, a turntable that combines a yoga studio, the fulfillment center, a hospital, and a cabin. David Burdick does the spot-on costumes, Harold F. Burgess II the moving lighting, and Sarah O'Halloran the terrific sound design.

Deborah Zoe Laufer directs her own play beautifully.

The 90-minute play flies by. It runs until Feb. 16, 2020. For tickets, call 410-752-2208 or visit http://www.everymantheatre.org.

On Sunday, Feb. 9 after the 2 p.m. matinee there will be Panel Discussion in partnership with the University of Maryland School of Social Work.

Following the Thursday Feb. 13 7:30 performance there will be a post-show talkback moderated by Resident Company Member Bruce Randolph Nelson.

Everyman's New Voices Festival begins with QUEEN'S GIRL BLACK IN THE GREEN MOUNTAINS running March 3 to April 12. BERTA, BERTA, runs March 17 to April 26. CRY IT OUT runs March 31 to May 3.

cgshubow@broadwayworld.com

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8 famous artists who dramatically destroyed their own artworks – Dazed

We look at why John Baldessari burnt his art and baked cookies with the ashes, Francis Bacon slashed his best paintings, and Robert Rauschenberg erased a work by Willem de Kooning

During the mid-20th century, the 'art of destruction' emerged as a theme in the work of many celebrated artists. Although this tendency has existed for centuries Claude Monet allegedly slashed at least 30 of his water lily canvases the 20th century heralded a new age for creative auto-destruction. Defined by artist Gustav Metzger in the 1960s, 'auto-destructive' art reflected the recent violence of the Second World War, the ideological nihilism of existential philosophy, and the rising tensions of nuclear warfare during the Cold War.

Conceptual artists sabotaged, ruined or destroyed their artworks, either as a deliberate, artistic strategy, or as a result of malaise, anxiety, or displeasure with their work. To destroy an art object was not only radical but iconoclastic a gesture that disavowed the artwork as a material object that could potentially sell for vast amounts of money.

Contemporary artists, from Gerhard Richter to Banksy, have followed in the footsteps of their predecessors. Ironically, some of these artists have proved that destruction isnt always defeatist, or for the purposes of sheer vanity, but allows for liberation, which in turn, inspires new bounds of creativity.

Named the godfather of conceptual art, John Baldessari passed away on 2 January 2020, at the age of 88. An artist who irreversibly changed the landscape of American conceptual art, he worked across all artistic mediums, from installation to video art to emojis.

In 1970, he decided to destroy his entire body of work created between 1953 and 1966. Rather than throwing them away, he took them to a crematorium. Afterwards, Baldessari stored the ashes in a bronze urn (in the shape of a book), which he placed on his shelf. He also bought a bronze plaque inscribed with the birth and death dates of his deceased works, as well as the recipe to make the cookies.

Cremation Project was not only practical but strategic Baldessari was commenting on the cyclical process of the creative process, which could be conceptually recycled.

At one point I made cookies out of the ashes, Baldessari reflected, only one person I ever knew ate one.

By erasing his past oeuvre, Baldessari cleared his artistic slate. The following year, he gave instructions for a work titled I Will Not Make Any More Boring Art an oath to never create dull work again.

In 1953, Robert Rauschenberg arrived at the house of abstract expressionist Willem de Kooning, who at that time was one of Americas most respected and highest-earning artists. Then, a little-known artist, Rauschenberg asked de Kooning whether he could erase one of his works.

Reluctant at first, de Kooning eventually agreed. He offered the 27-year-old Rauschenberg a pencil, ink, charcoal, and graphic sketch. Over the following two months, Rauschenberg erased the artwork. When finished, he retitled it Erased de Kooning Drawing (1953)

Echoing the readymades of Marcel Duchamp and precipitating the arrival of appropriation art, Rauschenbergs gesture ignited conversations about the limitations of art (specifically, can art be created through erasure?), as well as questions about authorship.

In late 1954, at the age of 24, Jasper Johns destroyed all of his work. Later in life,he would reflect that it was time to stop becoming and to be an artist... I had a wish to determine what I was... what I wanted to do was find out what I did that other people didnt, what I was that other people werent.

Just as Baldessari found a new vision after destroying his work, the obliteration of Johns practice boosted his creativity as if freed from the intellectual shackles of his former self.

Not long after, Johns dreamed of painting an American flag. Shortly after, he made his dreams a reality and conceptualised his most famous work, Flag, 1954.

In 1967, the Canadian-born painter Agnes Martin one of the few female members affiliated with abstract expressionism decided to destroy her earlier works. Known as a reflective and quiet woman, her modular, muted paintings reflect a desire for tranquillity.

Before dedicating her energy to the motif of lines, bands, and the grid (her trademark) she experimented with biomorphic abstraction: pale-hued paintings influenced by organic, or geometric forms. Her mature style developed in the 1960s and moved towards restrained abstraction.

1967 brought about great rupture in Martins life. Not only did she experience the sudden death of her close friend, the artist Ad Reinhardt, but she also suffered from a decline in mental health, which would eventually lead to schizophrenia in her 40s. She retreated from New York and left for New Mexico where she followed the principles of eastern philosophy: Zen Buddhism and Taoism.

Martins decision to negate her former style could be read as a purifying of her former life as she embarked on a new journey, albeit one characterised by descending mental health. Her displeasure for her older work was so great, that she commented that if collectors wanted to sell them back to me, Id burn them.

Towards the end of Georgia O'Keeffes life in the 1980s, she purged works of art she no longer liked. But she also destroyed photographs by her former husband, Alfred Stieglitz.

Among many paintings, she attempted to bury Red and Green II (1916), an early watercolour that she documented as destroyed in her personal notebooks. Only publicly displayed once, in New York in 1958,O'Keeffes work despite her attempts to remove it resurfaced at a Christie's sale in November 2015.

After Francis Bacons death in 1992, hundreds of destroyed canvases were found in his cluttered studio in South Kensington. In total, 100 slashed canvases were retrieved from his home.

Known for his masochistic tendencies and emotionally-charged works, the cycle of creation and destruction was central to Bacons torturous, creative process. He allegedly referred to his art as an exorcism a cathartic, painful release of raw emotion. And once described the violent application of his paint as to do with an attempt to remake the violence of reality itself.

One of the destroyed works found in his studio Gorilla with Microphone used his repeated motif of a glass box, within which a central figure was cut out, leaving two white, negated spaces.

According to Jennifer Mundy, Bacon reflected that some of his destroyed works were among his best. He found it difficult to finish a work, and his canvases often became so clogged with pigment that they had to be discarded. He also routinely destroyed works he was not pleased with.

Noah Davis was a prodigiously talented LA-based painter who founded the Underground Museum. He tragically died aged 32 from a rare form of cancer in 2015, though he left an impressive artistic legacy.

A visionary and efficient painter who followed the mantra of less is more, one of his closest friends, Henry Taylor, described him as an artist who was constantly growing.

According to Bennett Roberts (the co-founder of Roberts & Tilton) The only problem with Noah, was that he would call me and say, Come to the studio, I painted 10 great new paintings. He was very fast when he was working. Id go in there and just be mesmerised. These are unbelievable, can we get them to the gallery? Ill photograph them. Two days later, he would say, Oh, sorry, I painted over every one of them.

Banksys self-shredding artwork dominated the headlines in 2018. When his most recognisable work, Girl With Balloon, sold for over 1 million at a London Sothebys auction,the artwork promptly began to self-destruct. Unbeknown to onlookers, the artist had previously installed an automated shredding device into the frame of the picture.

Shortly after, Banksy uploaded a video of the scandalous moment on his Instagram account, with the caption Going, going, gone Ironically, the destruction of the work was left incomplete; the work was supposed to shred entirely but stopped halfway through. To the surprise of many, the artwork increased in value after its public decimation.

In homage to Picasso, Banksy remarked: The urge to destroy is also a creative urge

One of the most prolific artists of the twentieth century, Louise Bourgeois left her New York townhouse in a state of bohemian disarray after her death in 2010. Known for her chronic anxiety, erratic moods, and sudden outbursts of creativity, the artists close friend and assistant, Jerry Gorovy once remarked, If she worked, she was OK. If she didnt, she became anxious... and when she was anxious she would attack. She would smash things, destroy her work.

If Bourgeois disliked a small sculpture shed been working on, she was known to push it off the end of her kitchen table and watch it smash and break into small fragments.

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8 famous artists who dramatically destroyed their own artworks - Dazed

The best Chicago albums of the 2010s | Music Feature – Chicago Reader

When I consider the past decade in Chicago music, I think about the songs and albums that not only muscled their way into my memory but also deepened my understanding of the place where I live. Music helped me navigate a city that seems to weather seismic sociopolitical changes several times per yearthe six months between the FBI's November 2018 raid of Alderman Ed Burke's office and the mayoral runoff election felt like a decade. Songs provided me with new insight into the forces driving the record single-year number of public school closings in 2013, the Emanuel administration's cover-up of Laquan McDonald's 2014 murder by Chicago police officer Jason Van Dyke, the City Council's approval of construction contracts for a $95 million police and fire academy in West Garfield Park, and the abuse of tax increment financing to assist billion-dollar developments that will help displace the disadvantaged people that TIFs are supposed to benefit. Chicago musicians not only consider the specifics of what it means to live in this city but also frequently engage the community with more than their songs. Their albums and activism shape the culture in Chicago and elsewhere.

My listening experience, rooted as it has been in Chicago, isn't reflected in the "best albums of the 2010s" packages that the country's major music and culture outlets published late last year. And I didn't expect it to be. They're concerned with the broader world of music or with a narrowly defined genre, not with a specific city. I knew these lists would exclude a lot of important Chicago music, even though the city left an indelible imprint on pop during the 2010s (hello, drill). So I wanted the Reader to undertake something similar that would be nothing but great Chicago records, top to bottom.

With that in mind, the music department set out to create a "best Chicago albums of the decade" project. We e-mailed ballots to dozens of music criticspodcasters, zine writers, bloggers, freelance journalistswho'd demonstrated their engagement with the local scene. Our definition of a "Chicago album" was fluid. The artist could be born here but now living elsewhere; a group of musicians from several cities could have convened here to record. The point was to encourage diversity, not artificially narrow the field.

Fifty-seven critics ranked their ten favorite Chicago albums from the past decade, and we compiled the results in an ordered list that wound up 338 albums long. A first-place pick earned ten points, a second-place pick nine, and so on till tenth place, which counted for just one point. This scoring system inevitably generated a lot of ties in the lower reaches of the listthere are only 44 numerical ranks assigned to all those albumsbut it also created some clear winners.

One benefit of a massive decade-long retrospective is that it can introduce wonderful music to an audience that missed it entirely the first time around. That possibility guided our decisions when we chose 50 of those 338 albums to get a little extra attention, in the form of a paragraph written by a critic who'd picked it. Instead of focusing on the records with the most votes, we looked for the ones that didn't seem to have gotten enough attention on other lists.

We also wanted to represent at least some of the dizzying breadth of Chicago music. As a result, this might be one of the most varied "decade in review" pieces you'll read, covering hip-hop, gospel, R&B, house, ambient, hardcore punk, jazz, metal, electronic noise, soul, indie rock, footwork, contemporary classical, powerviolence, and whatever you want to call Fire-Toolz. Whether an album listed here tied for 44th place or came in fourth, it's important and worth your time. You might not agree with the rankings or even the picks, but we hope you'll listen with an open mind.LeorGalil

Click here to see the individual ballotscompiled for this list.

Twenty-six-way tie, one point each

Saxophonist Dave Rempis is a vital part of the improvised-music community in Chicago and beyond, not just for his playing but also for his networking and programming, and he's in so many great groups that it's a fool's errand to choose just one. But I'm a sucker for bands with two drummers, and when those drummers are Tim Daisy and Frank Rosalytwo of the best goingwell, that's game, set, and match. This burly, long-running ensemble is equally exhilarating whether creating engrossing textural explorations or dense, muscular grooves, and Rempis likewise excels wherever he ventures: thoughtful melodies, driving ostinatos, explosive abstract flights. Best of all, every so often the furious turbulence of the rhythm section (which also includes bassist Ingebrigt Hker Flaten) creates such a powerful updraft that Rempis's scaldinghorn practically reaches low Earth orbit.Philip Montoro

Thirty-two-way tie, two points each

When I first heard Willis Earl Beal, it seemed like his disarmingly shambolic acoustic lullabies could articulate every complicated emotion I was having but couldn't name, then broadcast them back to me. The Chicago native recorded Acousmatic Sorcery on a RadioShack karaoke machine using cheap or scavenged instruments, and even his most fragile song felt like it could break open the earth. My 2011 Reader story on Beal helped him land a deal with XL Recordings, which put out Acousmatic Sorcery the following year (Ihelped write the bio for his press release). Beal's evolution continues to produce music that expresses bittersweet yearning with rare and idiosyncratic power, but I'll always cherish his debut.Leor Galil

Chicago is well-known for forward-thinking metal, but few albums capture the city's 2010s vibe like the second full-length from blackened sludge crew Lord Mantis. Locrian and Pelican coursed between beauty and despair; Yakuza and Gigan spun heady, psych-addled trips; Oozing Wound and Bongripper, well, ripped. But meanwhile, Lord Mantis stewed in misanthropy, nihilism, and back-alley grime. Produced by Sanford Parker, Pervertor isn't for the faint of heart: it's uncompromisingly bleak and demands a visceral response. The band have gone through multiple transformations since 2012, among them suffering the loss of founding drummer Bill Bumgardner in 2016, yet they've perseveredand Pervertor remains one of Chicago's most ferocious musical exports.JamieLudwig

The Numero Group had already offered a rough idea of what its Cult Cargo series was about with compilations sourcing material from Belize and the Bahamas, but 2011's Salsa Boricua de Chicago flipped the concept of "American music reinterpreted by people in the Caribbean" on its headit features artists of the underserved Cuban, Mexican, and Puerto Rican diasporas in Chicago. Culled from the 1970s output of the Ebirac label, run by community activist Carlos Ruiz, Salsa Boricua includes amateur orquestas throwing down vibrant salsa, guaguanc, guajira, merengue, bolero, and rumba grooves that could match anything coming out of New York or Miami. Lock in and let the funk out.PatrickMasterson

Before Shaquon Thomas introduced himself to the Chicago hip-hop scene as Young Pappy, the stories told through drill music were set almost exclusively on the south and west sides of the city. In 2015 Pappy released the mixtape 2 Cups: Part 2 of Everythingthe second installment of a series named after his slain friend Mensa "2 Cups" Kifleand definitively expanded the geography of drill to the north side, Uptown in particular. Pappy had some success with his music while alive, but 2 Cups: Part 2 of Everything (hosted by DJ Legacy) has earned him mostly posthumous famehe was murdered at age 20 in May 2015, just weeks after its release. The lead single, "Killa," has become part of the drill canon, and Pappy's lyrics throughout the mixtape use graphic accounts of aggression and passion to paint a nightmarish picture that testifies to his artistry.MattHarvey

Twenty-six-way tie, three points each

She was introduced to Chicago in 2011 as "that girl toting the pistol in Shady's 'Go In' video," but by the time she'd dropped her first project, Bandz and Hittaz, Katieor Katiiiieeee, as her signature ad-lib wenthad become the de facto queen of drill. The project, produced entirely by her cousin BlockOnDaTrack, has never gotten its due as one of the era's best releases, but tough, minimalist bangers such as "I Need a Hitta" and "Ridin' Round and We Drillin" epitomize the spirit of golden-era drill. I'll never forget the night at some bougie Pirate Bay-sponsored party at Lumen when the DJ dropped "Hitta" no less than three times in an hour.MeaghanGarvey

In the spirit of albums by predecessors such as John Zorn and Marc Ribot, Dustin Laurenzi's Snaketime cleverly expands the jazz palette by exploring a forerunner who stood sideways to the canon. In this case, the forerunner is Viking-helmed, Bach-influenced Beat street musician Moondog, whose strong sense of melody and deft use of counterpoint and minimalist repetition provide a vivid, pleasing structure within which Laurenzi's octet can interweave hummable tunes and brawling skronk. It's avant-garde jazz at its most accessible or mainstream jazz at its most avant-garde, depending on how you want to hear it. Either way, it's a joyand evidence of the talent and genius to be found in the Chicago jazz scene's nooks and crannies.NoahBerlatsky

Twenty-nine-way tie, four points each

Chambers is the 2013 debut of Spektral Quartet, a Grammy-nominated string ensemble that often operates in the classical realm and just as often redefines it. The album is an entirely Chicago affair, released on Parlour Tapes (a local cassette-focused label dedicated to contemporary art music) and featuring works by six local composerswhich Spektral Quartet attacks with Windy City grit and passion. On the LJ White piece Zin Zin Zin Zin (credited to Liza White and inspired by Mos Def's wordless freestyling on the Roots song "Double Trouble") the musicians get about as percussive as possible while mostly bowing their stringsyou can hear them strike their instruments while making sonic booms of downstrokes.SalemCollo-Julin

Twenty-eight-way tie, five points each

DJ Taye's Still Trippin' is a consummate turn in progressive footwork. The Teklife member employs a palette of rap, R&B, New Jersey club, Baltimore club, and more to make the argument that footwork spans style and region, while also reconstructing songwriting's role in the Chicago subgenre. As frenetic as footwork can be, Still Trippin' is framed by the meditative, wordless introductory track "2094," which immediately dissolves the listener in the recesses of the artist's mind. The rest of the album unfurls in surprising leaps from one aesthetic to another, and nothing is misspentthe young virtuoso forges ahead to somewhere new, his world a kaleidoscopic milieu.Tara C.Mahadevan

Three-way tie, 5.5 points each

Nicholas Szczepanik began releasing sublime drone pieces late in the aughts, just as I discovered the joys of solo walks, and they remain my favorite companions for ten-mile rambles through Chicago's neighborhoods. The best of those albums, 2011's Please Stop Loving Me, begins with a bottomless current of churchy organlike chords that seems to come from just out of view, swelling through slowly shifting musical shapes as if from within a bank of clouds. Eventually, Szczepanik resolves the drone into a massive final chord that feels like finding the peace of home after a long journeyit's a sanctifying balm to those of us dedicated to spending time alone, whether by choice or not.J.R. Nelson

Over the course of the past decade, Natalie Chami, who records and performs as TALsounds, has mastered the art of making her totally improvised musicloops of billowing, burbling synths topped by the breathy arias of her vocalssound as melodious and cogently narrative as a meticulously produced pop song. Her standout 2017 release, Love Sick, is as challenging and rewarding as anything by Bjork or FKA Twigs, with the same internal drama as an all-consuming love affairand the same splendid highs and lows. I can easily imagine "I Can't Sleep" topping the charts in a musical universe more keen on free exploration than our own.J.R. Nelson

Thirty-way tie, six points each

Despite blowing up off the 2012 smash hit "Kill Shit," Lil Herb always refused to be labeled a drill artist. He showed us why on his 2017 debut album as G Herbo, Humble Beast. With raw, honest retellings of street tales mixed with sobering reflections on his childhood, the 21-year-old contextualized and humanized the violence that defined Chicago drill. Humble Beast balances soulful production, gritty yet introspective rhymes, and club hits, showing Herb beginning to master his craft and catapulting him into position to become one of rap's brightest stars.Aaron AllenII

King Louie's earliest work was rough around the edges, a prophecy of Chicago rap's national breakthrough. Yet initially, he highlighted a knowing sense of humor that suggested, if not optimism, then at least the personality to bridge the gulf between a far-flung regional satellite and the mainstream. Then the Chicago scene suddenly went supernova, creating a darkly controversial new center of gravity. His response, Tony, was Louie's best project of the decade, despite being his least colorful and most tersely aggressive, because he recognized that the ground had moved beneath everyone's feet. He went back to the source for a brooding, apocalyptic project that managed the neat trick of charging its grimly violent times with undeniable electricity. It also launched three classic street singles: "Til I Meet Selena," "Live & Die in Chicago," and "B.O.N.," the last of which spawned re-versions coast to coast.David Drake

A gem of Chicago's underground, instrumental quintet Monobody play a multifaceted prog-rock fusion with expansive shifts in sound and style. Raytracing, their masterful second album, journeys through prog rock, jazz, postrock, melodic math rock, and even the occasional metal riff. Monobody supplement their pulsing piano passages, squiggly synth lines, heavy bass grooves, and rollicking guitar leads with lap steel guitar, vibraphone, and programmed electronics to create a cornucopia of techniques and timbres. And unlike prog percussionists who go overboard, drummer Nnamdi Ogbonnaya crafts intricate, propulsive beats that always mesh with their surroundingshe knows when to pull back and when to go all out.Scott Morrow

Twenty-six-way tie, seven points each

Coping already have the classic emo one-album-and-done trope coverednow they await rediscovery. The band's sole full-length, 2012's Nope, opens with a screaming call-and-response vocal passage that bleeds teenage angst: "Have you ever thought that I don't care for anything you have to say to me?" The band's unabashed youthful confidence and willingness to be obnoxiously disorienting recalls local emo legends Cap'n Jazz as well as their own emo-revival influences, Snowing and Algernon Cadwallader. Nope is an exhilarating 100-meter dash of unhinged emotional exasperations and tangled guitars, with the melodies acting only as a home base to return to. Into this outpouring, Coping incorporate teenage love, awkwardness, heartbreak, and rebellionthe makings of a benchmark record for midwestern emo.TJ Kliebhan

Cupcakke may be retired from rap, at least for the moment, but her second full-length, 2017's Queen Elizabitch, is still out there turning heads. Her music is witty, authentic, and often hilariously explicit, with track titles such as "Cumshot" and lyrics that straddle the line between playful and raunchy ("I save dick by giving it CPR," for instance, or "I'm tryna fuck for a buck, not make love to Jodeci"). Queen Elizabitch also shows us the diversity in Cupcakke's repertoire: on "33rd" she's upbeat, poppy, and inspirational, while on "Reality, Pt. 4" she raps a capella about her struggle to find an audience, her thoughts of suicide, and the hunger and poverty she endured growing up in Washington Park. She may be famous for her salacious rhymes, and it's true, she's all thatbut she's also a lot more.S. Nicole Lane

Catherine Irwin and Janet Beveridge Bean have recorded as Freakwater mostly in Chicago, but seven albums and 25 years into their career, they shifted to Louisville, expanding their band with some north Kentucky musicians. The result is Scheherazade, filled with looser, bigger versions of their gothic country dirgesan aesthetic with more sweep and more serrated edges. "Down Will Come Baby" is a characteristically uncanny track, turning the lullaby "Rock-a-bye Baby" into a loping Morricone outlaw epic for murdered infants. Every song on Scheherazade swings and rasps; you don't want them to stop, even as they cut you. Though Irwin and Bean will probably always be better known for their classic 90s material, this record may be their most perfect.NoahBerlatsky

No stranger to hard times, gospel singer Donald Gay has faced formidable challenges over the past decade. In 2010, he became the only surviving sibling of a legendary musical family when he lost his last elder sister, pianist Geraldine Gay (the Gay Sisters scored gospel hits from the late 1940s through the '60s). But on his debut as a leader, released when he was 73, his deep bluesy feeling and sure command of his material remain undiminished. On a Glorious Day, which juxtaposes songs by his sisters with time-tested standards, demonstrates again and again how resolutely life-affirming gospel can be. Appearances by Donald's son, vocalist and coproducer Gregory "Juno" Gay, and by his guitarist nephew, Donald "Bosie" Hambric, also testify to his thriving lineage and the vitality of the tradition.AaronCohen

Raw house music producer Jamal Moss, aka Hieroglyphic Being, has been inspired by otherworldly jazz keyboardist and composer Sun Ra since the start, so his collaboration with longtime Sun Ra Arkestra alto saxophonist Marshall Allen for RVNG Intl. was a dream come true. The result is a mix of live ingredients, including digital horn, polyrhythmic drumming, and spoken word. J.I.T.U. means "Journey Into the Unexpected," and this albumdrawn from nine days of jam sessions with six musicians and two vocalists, all composed and conducted by Mosslives up to that name, merging unpredictable industrial-edged house beats with free-jazz experimentation.JacobArnold

Twenty-five-way tie, eight points each

Twenty-three-way tie, nine points each

Jointly led by drummer Mike Reed and vibraphonist Jason Adasiewicz, the ensemble Living by Lanterns has released just one album: New Myth/Old Science, a magnificent study in artistic transformation and a special entry in Reed's ongoing investigation of post-1950s Chicago jazz history. Reed and Adasiewicz started with an enigmatic 1961 tape found in the Sun Ra collection of the Creative Audio Archive (located at Ravenswood's Experimental Sound Studio), extracting fragments and ideas from the rehearsal recording and expanding them into a suite of compositionsnot strictly Ra, not strictly them, but occupying some creative interzone. The ensemble mingles Chicagoans and New Yorkers, and the result is a constant delightswinging, buoyant, open, and prodding, with a scintillating lineup that includes Greg Ward's mercurial alto saxophone and Mary Halvorson's tensile guitar.JohnCorbett

Cellist Tomeka Reid had already been a valuable part of the Chicago jazz scene for years when her quartet released its self-titled debut in 2015and soon thereafter, she took on the world. Now based in New York, Reid creates new improvisational paths for string-forward groups not only with her own bands but also as a valuable member of the Art Ensemble of Chicago. The foundations of those explorations can all be heard here: myriad kinds of electricity flow through Reid's exchanges with guitarist Mary Halvorson, and the album also showcases Reid's superb compositions, including the lyrical "Etoile" and the open-ended "Glass Light."AaronCohen

Teen heartbreak is real. In 2014, there wasn't a high school on the south and west sides where you couldn't find teenage girls passionately singing "Somebody real is hard to find," the opening lines of Tink's "Treat Me Like Somebody" from Winter's Diary 2. Since her debut in 2011, the rapper and singer-songwriter has been releasing mixtapes that teens would rush to download from DatPiff, but this 2014 project is what arguably propelled her name beyond Chicago. The essence of Winter's Diary 2 reflects beloved 90s R&B, yet it's also relevant to the newer forms of heartbreak theInternet age introduced to relationships.JanayaGreene

Twenty-three-way tie, ten points each

The second full-length by Chicago heroes Arriver is a departure for metal: it's creative and interesting, rather than getting lost in an unthinking preoccupation with what's supposed to make metal "metal." Tsushima is progressive in the truest senseit draws from many inspirations, including a 1905 naval battle during the Russo-Japanese War, rather than from just oneand it dances through its amalgam of styles without losing its identity. Identity is key for Arriver, and they derive their sense of artistic self in no small part from their mental intensity: the brawn of Tsushima is more multifaceted than single-minded, more extravagant than restrained, and more cerebral than visceral.JonRosenthal

"Things fall apart, the center cannot hold," Cesar Robles Santacruz sings in "Satisfying Texture," the delicately unwieldy postpunk jam at the heart of 2019's Rotten Codex. For the past half decade, Bruised have been steadily gaining ground in the city's punk scene with their brooding, goth-infused tunes, and this full-length shows the quintet at their musical peak. Unlike many punk releases, it's never repetitive, swinging through a wide range of soundsincluding the driving, intense "Psychic Stain" and the drony, industrial "No Neutral Architecture." Bruised speak perfectly to the unbearable heaviness of these times, which we endure (to quote "Psychic Stain") by "looking for an answer in the dark."KerryCardoza

The theater of Cave comes through best in the nuances of their Krautrock-shaped psych, and 2011's classic Neverendless captures the band at their absolutely most Motorik. To maintain the effectiveness of such exactingly steady repetition, they have to set a mood by carefully modulating every sound swirling, twirling, and wriggling around the edges of the trackwhether produced by Moog or man. The 14-plus-minute "This Is the Best," with its ceaseless, almost taunting outro, and its follow-up, "Adam Roberts," with its swelling synths and a jaunty organ line, do this with a precision that you might overlook if you allow the foursome's rhythmic thrum to hypnotize you.KevinWarwick

On her third album as Fire-Toolz, Angel Marcloid cooks up a kitchen-sink combination of industrial, vaporwave, new age, dance pop, and black metal, peppered with AOL sign-on dings, cat meows, and that riff from "43% Burnt" by the Dillinger Escape Plan. At times, it sounds the way logging on has felt for the past couple yearsthat is, like slamming a nonstop torrent of news, opinions, and advertising into your brain at 100 miles per hour. It's a testament to Marcloid's skill and curatorial acumen that Drip Mental makes sense of it all, balancing its disorienting deluge against the exhilaration and joy of discovery. I found peace here when nothing else could soothe my overwhelmed mind.EdBlair

During the years that Robbie Fulks played regular Mondays at the Hideoutperforming 250 staggeringly varied shows from 2010 through 2017the club sometimes felt like a campfire gathering of sure-handed musicians fondly recalling tunes they'd heard long ago, breathing new life into their melodies with each pluck of a string. In the midst of that remarkable residency, Fulks released Gone Away Backward, a studio album that beautifully captures the craftsmanship and collaboration of his most intimate acoustic concerts. Deftly singing wise and witty lyrics that roam across the American landscape, Fulks made indelible 21st-century Chicago music built on memories of old-time Appalachia.RobertLoerzel

Radical hardcore band La Armada hail from the Dominican Republic, where they put down their roots in political activism and became a force in the country's punk community. After relocating to Chicago in 2007, they released their self-titled full-length debut in 2012. The band pair their fierce sound, heavily influenced by grindcore and powerviolence, with raw antiestablishment lyrics (all in Spanish) that focus on immigration, colonialism, and class struggle. The guttural opening words of the first track, "Esclavitud Organica" translate to "Hypocrisy! Cynicism! Falsehood! Eat shit!"describing the world in crisis that LaArmada are fighting to destroy and save.S.NicoleLane

In his merely extremely ambitious past projects, Damon Locks often used urgent, ethereal vocals that evoked June Tyson's work with Sun Ra, but for this Big Bang of ambition he's assembled a radical squadron of genius vocalists, instrumentalists, and dancers who draw on decades of Black Arts Movement audio, centuries of African music, and millennia-to-come of Afrofuturism. It seems too on-the-nose to use the word "art" to describe this album, considering that the second sleeve of its gatefold cover contains (in lieu of another piece of vinyl) a series of stunning prints by Locks. But this masterpiece is everything I want, and more than I expect, from art.JakeAusten

In the 2010s, Ken Vandermark appeared on at least 100 records. The veteran saxophonist and clarinetist takes the Braxtonian imperative of self-documentation very seriously, and his recordings are rarely casual affairsthe quality goes in before the name goes on. But New Industries is his achievement of the decade. Made with Marker, a band of exciting younger Chicagoans that's also the newest group under his leadership, the 2019 album combines impeccable studio recordings with a companion CD of live versions that suggests how the scores invite reinvention each time out. With this ensemble, Vandermark has found the best vehicle yet for his compositional concept, funneling postpunk energy into exploding architecture. Issued in physical form on the reedist's own Audiographic label, New Industries sold out immediately. It resolutely requires a reprint.JohnCorbett

Before becoming Chicago's most exciting rock band with the release of 2017's Nothing Valley, Melkbelly dropped a modest six-song EP-almost-LP in 2014, limited to 500 copies, via now-defunct label Automatic Recordings. At one moment raw and unrelenting, at the next haunting and ethereal, Pennsylvania occasionally shows its stitchesit's clearly the work of an underground group trying to iron out its identity and ambitions. But more important, it also demonstrates the band's early willingness to experiment with mood, as well as their inventiveness in lashing their melodic pop structures with freakish rhythms and howling noise. These brilliant songs are the first evidence that Melkbelly would become one of Chicago's most important revelations of the 2010s.KevinWarwick

With the 2014 album Kenny Dennis III, rapper Serengeti was poised to wrap up the saga of the fictional Kenny Dennis (his uber-Chicagoan alter ego) and his partner Jules, but their tale continued through the rest of the 2010s. It made a midlife crisis sound wonderfully odd, and it made Odd Nosdam sound like one of the best producers in the game. The album's use of actor Anders Holm as Kenny's estranged friend/outside POV may also be the last time skits made sense on a hip-hop album. If you don't want an O'Doul's and a hot dog by the endof this one, you've listened to it wrong.JillHopkins

Dr. Charles Joseph Smith's instrumental concept album War of the Martian Ghosts refracts his story of war and ghosts through the lens of dissonance and decay. With little but its ten track titles and stereophonic piano, Smith transports the listener to a Martian landscape, strange and mystical, akin to that imagined in Robert Heinlein's Stranger in a Strange Land or Philip K. Dick's Martian Time-Slip. Smith shapes and reshapes his virtuosic piano playing with fierce experimentation: chaotic time-signature jumps, ever-shifting motifs, occasional gothy synth accompaniment, a one-minute interlude of distant and unevenly spaced legato chord strikes, and even a 20-second punked-out track called "Recapitulation," whose tongue-in-cheek take on the device of recapitulation in classical music demonstrates the sense of humor integral to Smith's life and work.NoahJones

This gorgeous album contains a traditional Shona song, six marimba solos by Jacob Druckman, and Third Coast Percussion's own arrangements of Philip Glass's Aguas da Amazonia. Its centerpiece, though, is a collective composition by the quartet that scores the 1966 short film Paddle to the Sea, storyboarded so tightly that big accents in the music land precisely atop dramatic cuts in the movie. Alternately lushly melodic and intriguingly knotty, filled with intricate multilayered rhythmic phasing that's simultaneously hypnotizing and baffling, Paddle to the Sea reminds us that the superhuman rigor that classical players struggle to achieve isn't an elitist aspirationrather than cut off such musicians from "regular" people, it opens up new ways for their work to engage us, both intellectually and emotionally.PhilipMontoro

Four-way tie, 11 points each

Whether you call it posthardcore, slowcore, emo, or indie rock, Slow Mass's debut full-length, On Watch, is definitely one thing: art. The 2018 album overflows with intricaciesit moves from a twinkling introduction ("On Watch I") to blistering chaos ("E.D.") and ends with a gentle, expansive poetic incantation ("G's End") that encapsulates the vastness of Slow Mass's expertise. I saw the band open two shows in 2019, and each time they delivered their set with cathartic potency. In the decade to come, they deserve to headline more shows of their ownand they've already started 2020 with two new singles.MadelineHappold

Two-way tie, 12 points each

Led by Todd Rittmann, Dead Rider accomplish a delightfully disturbing perversion of rock 'n' roll that befits an alumnus of U.S. Maple and Cheer-Accident. On the band's second full-length, turgid bass synth, louche horns, and Rittmann's creepy, oleaginous croon and jagged spurts of guitar all contribute to an atmosphere of decadent, addictively groovy decay. Much of the music's distinctive feel comes from the drumming, shared here by Theo Katsaounis and his eventual replacement, Matt Espy: they stagger and stumble, slipping out of phase or just flat-out falling through the floor, but they always snap right back on beat to let you know they meant to do that. As Hannibal Lecter has proved in other venues, deviance kept under tight control is often more effective than off-the-leash craziness.PhilipMontoro

Eight-way tie, 13 points each

Why waste money on anger-management classes or a gym membership when you can create one of the grooviest powerviolence records ever to emerge from Chicago's hardcore metal scene instead? In 2011, Weekend Nachos did just that with their fourth LP, Worthless. It's an unforgiving record fueled by a fury that can only be expressed with crushing layers of distortion and rage-filled lyrics. The band combine their merciless grooves with brutal hardcore breakdowns and sandwich them between some of the city's heaviest doom riffs to create a powerviolence masterpiece that couldn't have come from anything but the grit and grime of Chicago.NikkiRoberts

Rapper-producer Tremaine Johnson, aka Tree, can spin a symphony out of a single broken-sounding sample. To make what he calls "soul trap," he also cribs from modern pop songs, cracking and warping pieces of them till they sound like dusties, then looping them amid bustling percussion. He's also an arresting rapper and a wise, vivid lyricist, with an endearingly coarse voice that underlines his weary empathy. He dropped a streak of fantastic albums in the 2010s, but his hard-won critical breakthrough, Sunday School, is stacked with so many knockout tracks that it's era defining.LeorGalil

Four-way tie, 14 points each

In a music industry that enforces constant output, Kaina wants us to slow down. The act of feelingand processing all the good and bad, complexity and confusion that comes with itis the overarching theme of Kaina's first full-length, Next to the Sun. Her voice is smooth, her energy is calming, and her lyrics (which she writes herself) effortlessly bounce around the luscious melodies she sings. Kaina has all the makings of a star, and between her eager experimentation with musical composition and her celebration of identity and all that forms it, she's refreshingly undefinable.BiancaBetancourt

Mako Sica are one of Chicago's most genre-shattering bands, and on their finest album, 2012's Essence, they feed their musical supercollider with jazz, psychedelic, experimental music, and more. They close the LP with the soundscape "Fate Deals a Hand," which stretches for more than 21 minutes, and side one's two sonic journeys are nearly as epic in scalenot unlike the outre experiments of Meddle-era Pink Floyd. Drummer Michael Kendrick augments his kit with all manner of bells, chimes, and cymbals, while Brent Fuscaldo adds basslike guitar, thumb piano, and clouds of whispered vocals. The final ingredient comes from genius guitarist Przemyslaw K. Drazek, whose textural waves of guitar and similarly treated trumpet lend a Morricone-esque soundtrack vibe to thealbumand to Mako Sica's unique sound.SteveKrakow

Four-way tie, 15 points each

When Ganser released their full-length debut, Odd Talk, they were still relative newcomers in the city's music scene, but the four-piece had already established themselves as a band to watch. With the sleek synths, disjointed guitars, and plentiful grooves of Odd Talk, Ganser have crafted a smart take on postpunk that provides a breath of fresh air even as it nods to Chicago's noise-rock past. Not every band can hit a sweet spot between sophistication, trepidation, and weirdness, but even when Ganser grapple with difficult modern relationships and personal, political, and existentialanxieties, they make it sound like a blast.JamieLudwig

Five-way tie, 16 points each

Listening to Lux is like fighting a fever dream: the paranoia, the quickened pulse, the winding line connecting beginning to end. Logically speaking, the full-length debut from a band who deliberately mischaracterized themselves as "CCR via Minor Threat" shouldn't have ended up among Chicago's musical masterstrokes of the past decade, but throughout their eight-year run, Disappears were always in the business of defying expectations. Riffs wobble like they're on sea legs, Brian Case's yawps sound tongue-tied and tipsy, and every drum fill pops like a pistolmore than an album, Lux is a postcard from another world.Shannon NicoShreibak

Four-way tie, 17 points each

Toupee's Leg Toucher, the four-piece's last full-length before disbanding, sounds like it was recorded mid-exorcism. Front woman Whitney Allen (now Whitney Fragassi) pivots from sludgy sneers to incoherent shrieks, and the mix might as well have been run through a blender set to "puree." Despite all this, the chaotic sound that Allen crafts with bandmates Nick Hagen, Mark Fragassi, and Scott Frigo still does exactly what they want it to do. Swirling goth-rock guitar riffs create an ominous backdrop, but the horror punk of "Mommy Is a Mummy" and "The Spider That Lives in Your Hair" channels Halloween-store camp rather than attempting actual terror.AnnaWhite

In the beginning, there was house, which borrowed from breakdancing to help form jukeand then Chicago gave birth to footwork, a dizzyingly fast and weird dance style accompanied by a similarly fast and weird turntablist-approved soundtrack. British electronic musician Mike Paradinas gathered 25 cuts by Chicago producers in 2010 and kicked off the decade with Bangs& Works Vol. 1 (on his own Planet Mu label), a genre-defining compilation of footwork music that includes innovators RP Boo and DJ Rashad. Vol. 1 helped some of the producers on its roster undertake international tours, and in 2011 it begat Bangs & Works Vol. 2.Salem Collo-Julin

Three-way tie, 19 points each

Three-way tie, 20 points each

Meat Wave's self-titled debut was never supposed to be an album. The band recorded nine songs with the intent of sprinkling them across a series of split seven-inches. When that fell through, the trioguitarist-vocalist Chris Sutter, bassist Joe Gac, and drummer Ryan Wizniakpieced together an album. From the caustic guitar stabs of "Keep Smoking" to the triumphant explosion that closes "Panopticon," Meat Wave merge the catchiness of Chicago punk with the austerity of the city's noise-rock greats, resulting in an album that doesn't just pay homage to the past but also uses that history to pave a new path forward.DavidAnthony

Two-way tie, 21 points each

Three-way tie, 23 points each

Singers and multi-instrumentalists Sima Cunningham and Macie Stewart birthed their debut full-length as Ohmme in 2018. Parts is a moody, avant-garde, psychedelic landslide that plunges you into the depths of some big questions: identity and the expectations that govern it, the meaning of consumption, and mislaid faith toward the end of a tumultuous decade. The album balances tensions and contortions against each other, whether personal or political, instrumental or vocal. Ohmme aren't exactly obscurethey lay it all out there, albeit in their own idiosyncratic waybut they build mystery all the same, stoking anticipation that buzzes and lingers even in the spaces between notes and songs. Sometimes Cunningham and Stewart provide answers to the questions they raise, but it's more fun to listen to the album and arrive at your own solutions to their lyrical puzzles.JessiRoti

Two-way tie, 26 points each

In 1983 the Reader called Ono "Chicago's best-kept secret." Here we are, nearly four decades later, still blessed more than we deserve. What is this blessing? Fearless avant-garde art that demands our surrender, nothing less. Ono drag us into the darkest conflicts of American history, but if you stay with themand the grooving bass lines ensure you willthey speak to our willingness to be called. There's nothing like a live Ono performance, but Spooks is a grand offering, recorded by two bands playing at once in counterpoint. The album is cinematic in its narrative construction, which gives shape to furious noise that sounds the emotional arc of characters voiced by poet-performer Travis, who spits, sasses, and bellows powerful, terrible words. Each listen unearths a new story arc, a new deviant sound, a new foundation beneath its noise, like sweeping a dirt floor. "You will never cover dirt!"SashaTycko

Two-way tie, 34 points each

Lala Lala's The Lamb is an immersive and illustrative experience, combining layered vocals, fearless exploration of varied sonic territory, and Lillie West's knack for honest and introspective storytelling. The London-born, Chicago-based songwriter showcases her creative growth on this sophomore effort, blending genres and ranging across the emotional spectrum on the album's 12 trackswhether the coaxing subtlety of "Scary Movie" or the jarring introduction of "I Get Cut." Throughout the record, melodies leap out that will stick withyou long after you've finished listening.RachelZyzda

Two-way tie, 37 points each

Feeding Frenzy is a relentless assault of D-beat hardcore from C.H.E.W.the payoff after a series of small releases brimming with promise. The groupcomprising three Orlando transplants and a front person who'd never sung in a band beforeare as brutal as they are seamless. Ben Rudolph, Russell Harrison, and Jono Giralt (the aforementioned transplants) click together with the intuitive precision of three players who know and understand one another's inner workings. Doris Jeane's raspy, mocking growl grabs listeners by the throat in confrontation and anguish.TimCrisp

DJ Rashad and his Teklife comrades poured decades of dance music into Double Cup. Its soaring vocal samples and pulsing kicks convey every emotion it's possible to feel while your sweat cools in the 4 AM air: pride, lust, anxiety, fear, ecstasy, bravado, and (by the time it concludes with "I'm Too Hi") utter intoxication. The album is haunted by the viscous trinity of highs alluded to in "Drank, Kush, Barz"ironic companions to the record's high-speed beats. Though Rashad's time with us was cut short, his legacy will live on through a lifetime of tracks, a generation of inspired producers, and the footwork masterpiece Double Cup.JackRiedy

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The best Chicago albums of the 2010s | Music Feature - Chicago Reader

Vizgen Launches with $14M Series A Financing Led by ARCH Venture Partners and Northpond Ventures – Yahoo Finance

Vizgen leverages validated, proprietary technology to push the boundaries of spatially resolved, single-cell transcriptomics, yielding unprecedented insight into molecular and cellular organization of both heathy and pathological tissues.

CAMBRIDGE, Mass., Jan. 30, 2020 /PRNewswire/ --Vizgen, a privately-held biotech company developing solutions for next-generation spatially resolved, single-cell transcriptomics, announced the closing of a $14 million Series A financing led by ARCH Venture Partners and Northpond Ventures. The investors have come together to accelerate productization of Vizgen's patented MERFISH (multiplexed error-robust fluorescence in situ hybridization)platform with the goal of empowering and commercializing this technology for research and development and eventual clinical use.

MERFISH is a quantitative and genome-scale multiplexed imaging technology for identifying nucleic acids in their native cellular and tissue environment [1, 2, 3]. MERFISH leverages error-correcting barcoding schemes and combinatorial labeling and imaging for near 100% detection efficiency and low false-positive rates at high throughput and low cost [1, 2, 3,4,5]. Deep profiling of RNAs in single cells in their native context by MERFISH reveals cell type, state, organization, interactions, and function within the tissue [6], providing an unprecedented window into health and disease.

The MERFISH technology was developed in the laboratory of Dr. Xiaowei Zhuang, a Howard Hughes Medical Institute Investigator and David B. Arnold Professor of Science at Harvard University. Dr. Zhuang was also the inventor of STORM, one of the first and most widely used super-resolution microscopy methods responsible for uncovering numerous novel cellular structures.

In addition to Dr. Zhuang, the co-founders of Vizgen also include David Walt, Ph.D., Core Faculty at the Wyss Institute at Harvard University, Professor of Pathology at Brigham and Women's Hospital, and Hansjrg Wyss Professor of Biologically Inspired Engineering at Harvard Medical School and Dr. Jeffrey Moffitt, Ph.D., Investigator at the Program in Cellular and Molecular Medicine at Boston Children's Hospital and an Assistant Professor in the Department of Microbiology at Harvard Medical School. Dr. Walt is a pioneer of single-molecule detection and analysis techniques and the scientific founder of Illumina Inc, Quanterix Corp, and several other cutting-edge life science companies. Dr. Walt will serve on Vizgen's Board of Directors. Dr. Moffitt co-invented MERFISH while a postdoctoral fellow in the laboratory of Dr. Zhuang and is a leader in the field of spatially resolved single-cell transcriptomics.

"MERFISH is a game-changing technology in single-cell genomics and has broad applications in both fundamental biology and medicine," said Dr. Walt. "Error detection and correction enable researchers to get the right answer. Vizgen's patented technology is critical for powering this unprecedented massively multiplexed single molecule detection capability. We are excited that this funding will help us make the technology broadly accessible to the community, greatly amplifying its impact."

"We are proud to join proven innovators like Drs. Walt and Zhuang in bringing this breakthrough technology to market," said Keith Crandell, Co-founder and Managing Director at ARCH Venture Partners. "The deep information unlocked by MERFISH exposes biology at the network level, driving insights that will help us build the future of human health."

About VizgenVizgen is a privately held biotech company developing the next generation of spatially resolved, single-cell transcriptomics technology and toolbox. The company's patented MERFISH technology enables massively multiplexed, genome-scale nucleic acid imaging with high accuracy and detection efficiency at subcellular resolution. The high throughput and resolution and the low cost per cell achieved by the technology will enable a wide range of tissue-scale basic research and development and will be instrumental to efforts to discover and map cell types and states in a range of tissues and organisms. Tools employing MERFISH will advance data-driven drug discovery and development and enable new insights for clinical pathology and diagnostics. For more information, please visit http://www.vizgen.com.

Story continues

About ARCHARCH Venture Partners is one of the largest early stage technology venture firms in the U.S. ARCH has co-founded and provided initial investments for more than 250 companies organized around innovations from research universities, national laboratories, corporate research groups and entrepreneurs. By focusing on leading scientific innovators, ARCH has been at the forefront of investing in major areas of innovation in the life sciences and physical sciences, and has helped to catalyze revolutionary advances in genomics, nanotechnology, industrial biotechnology and major disease treatments. ARCH has raised ten primary funds with combined committed capital at the time raised of approximately $4.5 billion. For more information please visit http://www.archventure.com.

About NorthpondThe round was co-led by Northpond Ventures,a global venture capital firm dedicated to science and technology.Northpond'sSharon Kedar,the Co-Founder and Partnerat the firm, will join the Vizgen team as a Board member.

Contact:Mary ConwayMConway@MKCStrategies.com516-606-6545

View original content:http://www.prnewswire.com/news-releases/vizgen-launches-with-14m-series-a-financing-led-by-arch-venture-partners-and-northpond-ventures-300996237.html

SOURCE Vizgen

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Vizgen Launches with $14M Series A Financing Led by ARCH Venture Partners and Northpond Ventures - Yahoo Finance

Precision Medicine Leaps Ahead with Data Science: Bio-IT World 2020 to Highlight Data-Driven Approaches to Discovery – Yahoo Finance

3,200 Life Science and IT Leaders to Unite for Conference and Expo, April 21-23 in Boston

Bio-IT World 2020, the leading conference and expo uniting life science, data, informatics and IT leaders, today announced an expanded focus on the Data Science innovations that are moving precision medicine into new frontiers.

More than 3,200 such experts from pharmaceutical, biotech, healthcare and technology organizations, government and academia will converge for the 19th annual event, taking place April 21-23, 2020 in Boston.

"Data science is foundational to life science companieschanging the competencies required to compete. The opportunities to push our industry to the edge of discovery are thrilling for those organizations that embrace a collaborative, data-driven approach," said Allison Proffitt, Editorial Director, Bio-IT World.

From a plenary keynote presentation on the National Institutes of Healths (NIH) Strategic Vision for Data Science, to a new Data Science and Analytics Technologies track with Bristol-Myers Squibb, Takeda and more, the conference will highlight effective strategies, analytics and tools.

Altogether, 16 conference tracks will cover AI for Drug Discovery, Bioinformatics, Data Storage and Transport, Pharmaceutical R&D Informatics, Cancer Informatics, Genome Informatics, Clinical Research and Translational Informatics, Data and Metadata Management, Data Visualization Tools, Emerging AI Technologies, AI: Business Value Outcomes, Software Applications and Services, Data Security and Compliance, Cloud Computing, and Open Access and Collaborations, in addition to Data Science and Analytics Technologies.

Other highlights include 250+ presentations, 160+ exhibitors, Plenary Keynotes, pre-conference workshops, a Hackathon, awards, poster sessions and networking. See details at bio-itworldexpo.com.

About Cambridge Healthtech InstituteCambridge Healthtech Institute (CHI), a division of Cambridge Innovation Institute, is the preeminent life science network for leading researchers and business experts from top pharmaceutical, biotech, CROs, academia, and niche service providers. CHI is renowned for its vast conference portfolio held worldwide including PepTalk, Molecular Medicine Tri-Conference, SCOPE Summit, Bio-IT World Conference & Expo, PEGS Summit, Drug Discovery Chemistry, Biomarker World Congress, World Pharma Week, The Bioprocessing Summit, Next Generation Dx Summit, Immuno-Oncology Summit, and Discovery on Target. CHI's portfolio of products include Cambridge Healthtech Institute Conferences, Barnett International, Insight Pharma Reports, Bio-IT World, Clinical Research News and Diagnostics World.

View source version on businesswire.com: https://www.businesswire.com/news/home/20200128005512/en/

Contacts

Dawn Ringel781-449-8456 or dawn@ringelpr.com

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Precision Medicine Leaps Ahead with Data Science: Bio-IT World 2020 to Highlight Data-Driven Approaches to Discovery - Yahoo Finance

Global Molecular Diagnostics Market is Likely to Surpass US$ 22.5 Billion by the End of Year 2025 – ResearchAndMarkets.com – Associated Press

DUBLIN--(BUSINESS WIRE)--Jan 30, 2020--

The Molecular Diagnostics Market Share & Global Forecast, By Application, Technology, End User, Regions, Companies report has been added to ResearchAndMarkets.coms offering.

Increasing prevalence of Infectious diseases such as Influenza, HPV, Hepatitis, HIV and Tuberculosis despite rise in sanitation practices globally. In the past, antimicrobials medicines were used to fight powerful infectious disease but slowly in todays time antimicrobial agent is not able to give the desired results because the problem of drug resistant occurs in many people across the world.

Nowadays, a new diagnostic procedure is being followed to fight infectious disease like molecular diagnostic test is very effective which is quite fast and precise. The number of cancer patients is increasing very fast, so it is believed that in the coming time the molecular diagnostic test market will be growing at rapid pace. Global Molecular Diagnostics Market is likely to surpass US$ 22.5 Billion by the end of year 2025.

There are various reasons that will propel the market growth in forecast year; rising incidence rate of infectious disease, increasing incidence rate of cancer of all type, increasing people awareness regarding molecular diagnostic, rapid technological growth, widely acceptance of personalized medicine, rising healthcare infrastructure, increasing healthcare per capita expenditure across the developed and developing nation, accuracy of diagnosis, growing population of cardiovascular and neurological disorder etc. In addition, increasing prevalence of genetic disorder will further boost the market in forecast period of time.

The report titled Molecular Diagnostics Market Share & Forecast, By Application (Infectious Diseases, Blood Screening, Oncology, Genetic Testing, HLA (Tissue Typing), Microbiology, Cardiovascular Diseases, Neurological Diseases, Pharmacogenomics and Others), By Technology (PCR, Transcription-Mediated Amplification (TMA), Hybridiazation (In-situ Hybridiazation & FISH), DNA Sequencing & NGS, Microarray and Others), By End User (Hospitals & Academic Laboratories, Clinics and Commercial Laboratories, Others), By Regions [United States, Europe (Expect Russia), India, China, Japan, Brazil, South Korea, Mexico, Russia and ROW], Companies (Roche, Abbott, Myriad Genetics, Qiagen, BioMrieux and Others) provides a complete analysis of Molecular Diagnostics Market.

Market Insight by Application

The report provides comprehensive analysis of molecular diagnostic test market by application into ten parts: Infectious Diseases, Genetic Testing, Blood Screening, Oncology, HLA (Tissue Typing), Microbiology, Neurological Diseases, Pharmacogenomics, Cardiovascular Diseases, and Others. This report also provides key opportunities market and specific factors are given by each application market.

Market Insight by Technology

Here the market is fragmented into six parts; PCR, Transcription-Mediated Amplification (TMA), Hybridiazation (In-situ Hybridiazation & FISH), DNA Sequencing & NGS, Microarray and Others. Besides, many factors are analyzed that influence the growth, challenges and opportunities of market in technological context.

Market Insight by End User

The report provides complete insight of market by End User segments: Hospitals & Academic Laboratories, Clinics & Commercial Laboratories and Others. According to the publisher, Hospitals & Academic Laboratories will hold the largest market in global molecular diagnostic test market in forecast period of time.

Market Insight by Regions

This report covers the complete regional profile by 10 geographical market; United States, Europe, India, China, Japan, Brazil, South Korea, Mexico, Russia and Rest of World (ROW).

Key Topics Covered:

1. Executive Summary

2. Global Molecular Diagnostic Market

3. Market Share - Global Molecular Diagnostics

3.1 By Application

3.2 By Technology

3.3 By Countries

3.4 By Companies

4. Application - Molecular Diagnostics Market

4.1 Infectious Diseases

4.1.1 Hospital Acquired Infections (HAI)

4.1.2 HIV / HCV Testing

4.1.3 STD Testing

4.1.4 HPV Testing

4.2 Blood Screening

4.3 Oncology / Cancer

4.3.1 Breast

4.3.2 Colorectal

4.3.3 Prostate

4.3.4 Others

4.4 Genetic Testing

4.5 HLA (Tissue Typing)

4.6 Microbiology

4.7 Cardiovascular Diseases

4.8 Neurological Diseases

4.9 Pharmacogenomics

4.10 Others

5. Technology - Molecular Diagnostics Market

5.1 PCR

5.2 Transcription-Mediated Amplification (TMA)

5.3 Hybridiazation (In-situ Hybridiazation & FISH)

5.4 DNA Sequencing & NGS

5.5 Microarray

5.6 Others

6. Region - Molecular Diagnostics Market

6.1 United States

6.2 Europe

6.3 India

6.4 China

6.5 Japan

6.6 Brazil

6.7 South Korea

6.8 Mexico

6.9 Russia

6.10 Rest of World (ROW)

7. End Users - Molecular Diagnostics Market

7.1 Hospitals & Academic Laboratories

7.2 Clinics and Commercial Laboratories

7.3 Others

8. Roche Diagnostics - Company Analysis

8.1 Merger & Acquisitions

8.2 Sales Analysis

9. Abbott Laboratories - Company Analysis

9.1 Merger & Acquisitions

9.2 Sales Analysis

10. Myriad Genetics - Company Analysis

10.1 Merger & Acquisitions

10.2 Sales Analysis

11. Qiagen - Company Analysis

11.1 Merger & Acquisitions

11.2 Sales Analysis

12. BioMrieuxs Inc - Company Analysis

12.1 Merger & Acquisitions

12.2 Sales Analysis

13. Market Drivers

13.1 Various Developments in the Molecular Diagnostics Landscape

13.2 Integral to Traditional Labs

13.3 Improved Assay / Test Efficiencies

13.4 Targeting Antibiotic Resistance

13.5 Next Generation Ultrasensitive Molecular Diagnostics

13.6 Increasing Investment in Genomics & Proteomics Research

13.7 Technological Advances in Molecular Diagnostics

13.8 Increasing Acceptance of the Personalized Medicine

13.9 Growing Molecular Diagnostics for Food Safety

14. Challenges

14.1 Dearth of Trained Professionals

14.2 Regulatory Issues

14.3 Various Factors Slowing Growth of Molecular Diagnostics

14.4 Reimbursement Capabilities

14.5 Quality Checkpoints, Awareness & Acceptance

For more information about this report visit https://www.researchandmarkets.com/r/j3on5s

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CONTACT: ResearchAndMarkets.com

Laura Wood, Senior Press Manager

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Global Molecular Diagnostics Market is Likely to Surpass US$ 22.5 Billion by the End of Year 2025 - ResearchAndMarkets.com - Associated Press

Strategies for Increasing the Effectiveness of Aromatase Inhibitors in | CMAR – Dove Medical Press

Giulia Grizzi,1 Michele Ghidini,2 Andrea Botticelli,3,4 Gianluca Tomasello,5 Antonio Ghidini,6 Francesco Grossi,2 Nicola Fusco,7,8 Mary Cabiddu,9 Tommaso Savio,10 Fausto Petrelli9

1Oncology Unit, Oncology Department, ASST of Cremona, Cremona, Italy; 2Oncology Unit, Internal Medicine Department, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy; 3Medical Oncology Department, SantAndrea Hospital, Rome, Italy; 4Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy; 5Oncology Unit, Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy; 6Medical Oncology Unit, Casa Di Cura Igea, Milan, Italy; 7Division of Pathology, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy; 8Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy; 9Oncology Unit, Medical Sciences Department, ASST of Bergamo Ovest, Treviglio, Italy; 10Breast Unit, ASST of Bergamo Ovest, Treviglio, Italy

Correspondence: Fausto PetrelliOncology Unit, Medical Sciences Department, ASST of Bergamo Ovest, Piazzale Ospedale 1, Bergamo 24047, Treviglio, ItalyTel +39 03 6342 4420Fax +39 03 6342 4380Email faupe@libero.it

Abstract: Neoadjuvant hormonal therapy (NEO-HT) is a possible treatment option for breast cancer (BC) patient with estrogen receptor positive (ER+) and HER2 negative (HER2-) disease. The absence of solid data on the type of drugs to be used and duration of treatment as well as lack of clear evidence of effectiveness of NEO-HT compared to chemotherapy (CT) reserve its use for patients with old age or frail conditions. However, the low pathologic complete response rate (pCR) obtained with tamoxifen or aromatase inhibitors (AIs) alone does not make NEO-HT as a suitable option for the neoadjuvant treatment of HR+ HER2-. The use of the cyclin-dependent kinase 4 and 6 (CDK 4/6) inhibitors palbociclib, ribociclib and abemaciclib of the mammalian target of rapamycin (mTOR) inhibitor everolimus and of the phosphoinositide 3 kinase (PI3K) inhibitor taselisib together with endocrine therapy (ET) has become a standard in advanced breast cancer, showing clinical effectiveness and significantly prolonging median progression-free survival compared to ET only. In the early phase disease, the use of ET together with CDK 4/6, mTOR and PI3K inhibitors is still investigational. Data from recent studies are promising even though less impressive than in metastatic setting. In this context, the use of genomic-transcriptomic tools (such as ONCOTYPE, PAM50) and the identification of novel biomarkers (ESR1, PI3Kca, PDGF-R) on tissue or with liquid biopsy could help to select patient prone to respond to endocrine-combined therapy and able to achieve pCR. With our review, we aimed at evaluating the current state of the art in the treatment of locally advanced breast cancer with NEO-HT.

Keywords: neoadjuvant endocrine therapy, breast cancer, CDK 4/6 inhibitors, mTOR inhibitors, PI3K inhibitors, aromatase inhibitors

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

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Strategies for Increasing the Effectiveness of Aromatase Inhibitors in | CMAR - Dove Medical Press

Link Between Autism and Cognitive Impairment Identified May Lead to New Treatments – SciTechDaily

Depicted are hippocampal neurons from a normal mouse (above) and a mouse bred to lack the eIF4G microexon (below). In the latter, there are fewer particles representing paused protein synthesis machineries. In these mice, higher levels of protein synthesis in neurons lead to disrupted brain waves and autistic behaviors as well as cognitive deficits down the line. Credit: Thomas Gonatopoulos-Pournatzis

Mouse study identifies a brain mechanism underlying social deficits and mental disability in a finding that could lead to new treatments.

Autism can bestow brilliance as well as cognitive difficulty, but how either scenario plays out in the brain is not clear. Now a study by University of Toronto researchers has found that a tiny gene fragment impacts the brain in a way that could explain swathes of autism cases that come with mental disability.

Researchers led by Benjamin Blencowe, a professor of molecular genetics in theDonnelly Centre for Cellular and Biomolecular Research, and Sabine Cordes, a senior investigator at Sinai Health Systems Lunenfeld-Tanenbaum Research Institute (LTRI), have identified a short gene segment that is crucial for brain development and information processing.Writing in the journalMolecular Cell, the researchers describe how an absence of this segment is sufficient to induce altered social behavior a hallmark of autism in mice, as well as learning and memory deficits, which are seen in a subset of autism cases.

Best known for difficulties in social interaction and communication, autism is thought to arise from mishaps in brain wiring during development. It can strike in various ways those who suffer from it can have superior mental ability or need full time care. Where on the autism spectrum a person falls depends in large part on their genetics, but most cases are idiopathic, or of unknown genetic origin.

Its very important to understand the mechanisms that underlie autism, especially in idiopathic forms where it is not clear what the underlying causes are, says Thomas Gonatopoulos-Pournatzis, a research associate in Blencowes lab and lead author of the study. Not only have we identified a new mechanism that contributes to this disorder, but our work may also offer a more rational development of therapeutic strategies.

Blencowes team had previously uncovered a link between autism and short gene segments, known as microexons, that are predominantly expressed in the brain. Through a process known as alternative splicing, microexons are either spliced in or left out from the final gene transcript before it is translated into a protein. Although small, microexons can have dramatic effects by impacting a proteins ability to bind its partners as required during brain development. However, how individual microexons contribute to autism is not clear.

The team focused on a specific microexon located in a gene known as eIF4G, which is critical for protein synthesis in the cell. They found that this microexon is overwhelmingly excluded from eIF4G gene transcripts in the brains of autistic individuals.

To test if the eIF4G microexon is important for brain function, Gonatopoulos-Pournatzis together with Cordes team bred mice that lack it. These mice showed social behaviour deficits, such as avoiding social interaction with other mice, establishing a link between the eIFG4 microexon and autistic-like behaviors.

A surprise came when the researchers found that these mice also performed poorly in a learning and memory test, which measures the animals ability to associate an environment with a stimulus.

We could not have imagined that a single microexon would have such an important impact not only on social behavior but also on learning and memory, says Gonatopoulos-Pournatzis.

Further analysis revealed that the microexon encodes a part of eIF4G that allows it to associate with the Fragile X mental retardation protein, or FMRP, which is missing from people affected with Fragile X syndrome, a type of intellectual disability. About a third of individuals with Fragile X have features of autism but the link between the two remained unclear until now.

eIF4G and FMRP associate in a complex that acts as a brake to hold off protein synthesis until new experience comes along, as the break is removed by neural activity, the researchers also found.

Its important to control brain responses to experience, says Gonatopoulos-Pournatzis. This brake in protein synthesis is removed upon experience and we think it allows formation of new memories.

Without the microexon, however, this brake is weakened and what follows is increased protein production. The newly made proteins, identified in experiments performed with Anne-Claude Gingras, Senior Investigator at LTRI, form ion channels, receptors and other signaling molecules needed to build synapses and for them to function properly.

But, making too many of these proteins is not a good thing because this leads to the disruption of the type of brain waves involved in synaptic plasticity and memory formation, as revealed by electrode recordings of mouse brain slices, in experiments performed with the teams of Graham Collingridge, Senior Investigator at LTRI, and Melanie Woodin, a professor of cell and systems biology at U of T.

Moreover, an excess of similar kinds of proteins occurs in the absence of FMRP, suggesting a common molecular mechanism for Fragile X and idiopathic autism.

Researchers believe that their findings could help explain a substantial proportion of autism cases for which no other genetic clues are known. The findings also open the door to the development of new therapeutic approaches. One possibility is to increase the splicing of the eIF4G microexon in affected individuals using small molecules as a way to improve their social and cognitive deficits, Blencowe said.

The study would not have been possible without a close collaboration among multiple teams contributing diverse expertise. Blencowe and Gonatopoulos-Pournatzis also worked closely with Julie Forman-Kay, a professor of biochemistry and Program Head and Senior Scientist in the Molecular Medicine Program at the Hospital for Sick Children, and Nahum Sonenberg, a professor of biochemistry at McGill University.

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Link Between Autism and Cognitive Impairment Identified May Lead to New Treatments - SciTechDaily

Gene fragment could explain link between autism and cognitive difficulties: U of T study – News@UofT

Autism is associated with brilliance as well as cognitive difficulty, but how either scenario plays out in the brain is not clear. Now a study by University of Toronto researchers has found that a tiny gene fragment impacts the brain in a way that could explain swathes of autism cases that come with mental health challenges.

Researchers led byBenjamin Blencowe, a professor of molecular genetics in the Donnelly Centre for Cellular and Biomolecular Research and Faculty of Medicine, andSabine Cordes, a senior investigator at Sinai Health Systems Lunenfeld-Tanenbaum Research Institute (LTRI), have identified a short gene segment that is crucial for brain development and information processing. Writing in the journalMolecular Cell, the researchersdescribe how an absence of this segment is sufficient to induce altered social behaviour a hallmark of autism in mice, as well as learning and memory deficits, which are seen in a subset of autism cases.

Best known for causing difficulties in social interaction and communication, autism is thought to arise from mishaps in brain wiring during development. It can strike in various ways. Those who experience it can have superior mental ability or need full-time care. Where on the autism spectrum a person falls depends in large part on their genetics, but most cases are idiopathic, or of unknown genetic origin.

Its very important to understand the mechanisms that underlie autism, especially in idiopathic forms where it is not clear what the underlying causes are, saysThomas Gonatopoulos-Pournatzis, a research associate in Blencowes lab and lead author of the study. Not only have we identified a new mechanism that contributes to this disorder, but our work may also offer a more rational development of therapeutic strategies.

Blencowes team had previously uncovered a link between autism and short gene segments, known as microexons, that are predominantly expressed in the brain. Through a process known as alternative splicing, microexons are either spliced in or left out from the final gene transcript before it is translated into a protein. Although small, microexons can have dramatic effects by impacting a proteins ability to bind its partners as required during brain development. However, how individual microexons contribute to autism is not clear.

The team focused on a specific microexon located in a gene known as eIF4G, which is critical for protein synthesis in the cell. They found that this microexon is overwhelmingly excluded from eIF4G gene transcripts in the brains of autistic individuals.

Hippocampal neurons from a normal mouse (above) and a mouse bred to lack the eIF4G microexon (below). The latter contains fewer particles that represent paused protein synthesis machineries. In these mice, higher levels of protein synthesis in neurons lead to disrupted brain waves and autistic-like behaviors as well as cognitive deficits down the line.

To test if the eIF4G microexon is important for brain function, Gonatopoulos-Pournatzis, together with Cordess team, bred mice that lack it. These mice showed social behaviour deficits, such as avoiding social interaction with other mice, establishing a link between the eIFG4 microexon and autistic-like behaviours.

A surprise came when the researchers found that these mice also performed poorly in a learning and memory test, which measures the animals ability to associate an environment with a stimulus.

We could not have imagined that a single microexon would have such an important impact not only on social behaviour but also on learning and memory, says Gonatopoulos-Pournatzis.

Further analysis revealed that the microexon encodes a part of eIF4G that allows it to associate with the Fragile X mental retardation protein, or FMRP, which is missing from people affected with Fragile X syndrome, a type of intellectual disability. About a third of individuals with Fragile X have features of autism but the link between the two remained unclear until now.

FMRPandeIF4G work together to act as a brake to hold off protein synthesis until new experience comes along, as the brake is removed by neural activity, the researchers also found.

Its important to control brain responses to experience, says Gonatopoulos-Pournatzis. This brake in protein synthesis is removed upon experience and we think it allows formation of new memories.

Without the microexon, however, this brake is weakened and what follows is increased protein production. The newly made proteins, identified in experiments performed withAnne-Claude Gingras, a senior investigator at LTRI and a professor in the department of molecular genetics, form ion channels, receptors and other signaling molecules needed to build synapses and for them to function properly.

However, making too many of these proteins is not a good thing because it leads to the disruption of the type of brain waves involved in synaptic plasticity and memory formation. This is revealed by electrode recordings of mouse brain slicesin experiments performed by the teams ofGraham Collingridge, a senior investigator at LTRI and a professor in the department of physiology, andMelanie Woodin, a professor of cell and systems biology at U of T and the dean of the Faculty of Arts & Science.

Moreover, an excess of similar kinds of proteins occurs in the absence of FMRP, suggesting a common molecular mechanism for Fragile X and idiopathic autism.

Researchers believe that their findings could help explain a substantial proportion of autism cases for which no other genetic clues are known. The findings also open the door to the development of new therapeutic approaches. One possibility is to increase the splicing of the eIF4G microexon in affected individuals using small molecules as a way to improve their social and cognitive deficits, Blencowe said.

The study would not have been possible without a close collaboration among multiple teams contributing diverse expertise. Blencowe and Gonatopoulos-Pournatzis also worked closely withJulie Forman-Kay, a professor of biochemistry and program head and senior scientist in the molecular medicine program at the Hospital for Sick Children, andNahum Sonenberg, a professor of biochemistry at McGill University.

The research was made possible by grants from the Canadian Institutes of Health Research, Simons Foundation and theCanada First Research Excellence Fund Medicine by Design program, among others.

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Gene fragment could explain link between autism and cognitive difficulties: U of T study - News@UofT

Myriad to Announce Fiscal Second-Quarter 2020 Financial Results on February 6, 2020 – Yahoo Finance

SALT LAKE CITY, Jan. 30, 2020 (GLOBE NEWSWIRE) -- Myriad Genetics, Inc. (MYGN), a leader in molecular diagnostics and precision medicine, announced that it will hold its fiscal second-quarter 2020 sales and earnings conference call with investors and analysts at 4:30 p.m. ET on Thursday, February 6, 2020. During the call, Mark C. Capone, president and CEO, and Bryan Riggsbee, CFO, will provide an overview of Myriads financial performance for the fiscal second-quarter and provide a business update.

To listen to the earnings call, interested parties in the United States may dial 800-757-5680 or +1 212-231-2938 for international callers. All callers will be asked to reference reservation number 21950986. The conference call also will be available through a live webcast and a slide presentation pertaining to the earnings call also will be available under the investor section of our website at http://www.myriad.com. A replay of the call will be available two hours after the end of the call for seven days and may be accessed by dialing 800-633-8284 within the United States or +1 402-977-9140 for international callers and entering reservation number 21950986.

About Myriad GeneticsMyriad Genetics Inc., is a leading molecular diagnostic and precision medicine company dedicated to being a trusted advisor transforming patient lives worldwide with pioneering molecular diagnostics. Myriad discovers and commercializes molecular diagnostic tests that: determine the risk of developing disease, accurately diagnose disease, assess the risk of disease progression, and guide treatment decisions across six major medical specialties where molecular diagnostics can significantly improve patient care and lower healthcare costs. Myriad is focused on five strategic imperatives: building upon a solid hereditary cancer foundation, growing new product volume, expanding reimbursement coverage for new products, increasing RNA kit revenue internationally and improving profitability with Elevate 2020. For more information on how Myriad is making a difference, please visit the Company's website: http://www.myriad.com

Myriad, the Myriad logo, BART, BRACAnalysis, Colaris, Colaris AP, myPath, myRisk, Myriad myRisk, myRisk Hereditary Cancer, myChoice, myPlan, BRACAnalysis CDx, Tumor BRACAnalysis CDx, myChoice HRD, EndoPredict, Vectra, GeneSight, riskScore, Prolaris, Foresight and Prequel are trademarks or registered trademarks of Myriad Genetics, Inc. or its wholly owned subsidiaries in the United States and foreign countries. MYGN-F, MYGN-G.

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Myriad to Announce Fiscal Second-Quarter 2020 Financial Results on February 6, 2020 - Yahoo Finance

Precaution only weapon to fight against emerging threat of coronavirus – The Nation

Karachi - Prof. Dr. M. Iqbal Choudhary, Director of International Center for Chemical and Biological Sciences (ICCBS), University of Karachi has said that precaution is the only weapon to fight against the emerging threat of the 2019 novel coronavirus (2019-nCoV). There is no pathological laboratory performing a diagnostic test in Pakistan for the confirmation of coronavirus infections, he lamented.

He was speaking at a meeting held at the National Institute of Virology, which works under the Dr. Panjwani Center for Molecular Medicine and Drug Research (PCMD), University of Karachi, on Tuesday. The meeting was also attended by Dr. Muhammad Rashid, senior research officer of the institute of virology, and other scientists.

Prof. Iqbal Choudhary expressed serious concerns over the media reports of the cases of corona viruses in Pakistan, pointing out that a recent cluster of pneumonia cases in Wuhan province of China was caused by the 2019 novel coronavirus.

He said that there was a need to monitor and control all immigrants and visitors, livestock and goods at entry points. People at all international airports should be scanned for temperature and suspected individuals should be examined in isolation, he said.

He said that the National Institute of Virology was working to produce quality researches and researchers who could play their due role in the area of research and development in the country.

Dr. Rashid, in the meeting, said that there were only seven coronaviruses known to infect human, the well-known examples of human coronaviruses were SARS and MERS both viral outbreak had caused significant life losses at their time of outbreaks.

Coronaviruses are group of viruses that generally exist and maintain their life cycle in animals like camels, bats, cats, snakes and other wild animals, he said, adding that. SARS has caused 774 deaths in southern China in 2002-3 and MERS was first identified in 2012 in Saudi Arabia has caused 858 deaths. The newly emerged coronavirus named as 2019-nCoV is the third highly-virulent entry into the humans, has already caused more than 100 deaths and the death toll rises every hour in China, he said.

The 2019-nCoV infection may cause mild to severe respiratory disease, initial clinically presentation include fever, dry cough, myalgia (muscle pain) and fatigue and gradually progress into sever productive cough (a cough that produces phlegm), episodes of headache, hemoptysis (coughing up blood) and occasional diarrhea, he said.

He said that in case of suspected invasion the person should be kept in isolation and treated within the confined premises. The nCoV is highly infectious it usually infects through mouth and nose, the use of a surgical mask can minimize the risk, he maintained.

He said that there was no vaccine available against nCoV neither any anti-viral drug found effective to fight against the viral infection.

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Precaution only weapon to fight against emerging threat of coronavirus - The Nation

NantHealth (NASDAQ:NH) Stock Rating Lowered by ValuEngine – Riverton Roll

NantHealth (NASDAQ:NH) was downgraded by analysts at ValuEngine from a sell rating to a strong sell rating in a report issued on Tuesday, January 14th, ValuEngine reports.

Separately, Zacks Investment Research downgraded shares of NantHealth from a buy rating to a hold rating in a research note on Thursday, December 19th.

Shares of NantHealth stock opened at $1.83 on Tuesday. The firm has a market cap of $204.65 million, a P/E ratio of -2.01 and a beta of 1.52. NantHealth has a twelve month low of $0.45 and a twelve month high of $2.75. The firms 50-day simple moving average is $1.17 and its 200-day simple moving average is $0.83.

NantHealth (NASDAQ:NH) last released its quarterly earnings results on Thursday, November 7th. The company reported ($0.15) EPS for the quarter, missing the Zacks consensus estimate of ($0.07) by ($0.08). The firm had revenue of $22.36 million during the quarter, compared to analyst estimates of $23.40 million. NantHealth had a negative net margin of 105.82% and a negative return on equity of 10,106.10%. Sell-side analysts predict that NantHealth will post -0.46 earnings per share for the current year.

Institutional investors and hedge funds have recently bought and sold shares of the stock. Paloma Partners Management Co grew its holdings in NantHealth by 436.1% during the second quarter. Paloma Partners Management Co now owns 91,100 shares of the companys stock valued at $48,000 after purchasing an additional 74,108 shares during the period. Tower Research Capital LLC TRC grew its holdings in NantHealth by 778.8% during the third quarter. Tower Research Capital LLC TRC now owns 45,988 shares of the companys stock valued at $33,000 after purchasing an additional 40,755 shares during the period. Finally, Paragon Wealth Strategies LLC acquired a new position in NantHealth during the fourth quarter valued at approximately $38,000. 2.81% of the stock is owned by institutional investors and hedge funds.

About NantHealth

NantHealth, Inc, together with its subsidiaries, operates as a healthcare technology company in the United States and internationally. The company engages in converging science and technology through an integrated clinical platform to provide health information at the point of care. It develops NantHealth solutions, including molecular profiling solutions, software, and hardware systems infrastructure, which integrates patient data management, bioinformatics, and molecular medicine to enable value-based care and evidence-based clinical practice.

Read More: What does cost of debt say about a companys financial health?

To view ValuEngines full report, visit ValuEngines official website.

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NantHealth (NASDAQ:NH) Stock Rating Lowered by ValuEngine - Riverton Roll