Fox News lawsuit would strip First Amendment protection from cable news, internet – Reporters Committee for Freedom of the Press

Are cable news channels protected by the First Amendment?

Thats the question teed up in a little-noticed lawsuit against Fox News for its COVID-19 coverage, which the plaintiff claims discounted the threat of the pandemic and led viewers to fail to protect themselves. The plaintiff, a small Washington state nonprofit called the Washington League for Increased Transparency and Ethics, or WASHLITE, is suing Fox for what it claims are violations of the states consumer protection laws.

Fox and WASHLITE have already gone back and forth on the consumer protection claim, but the nonprofit filed an extraordinary brief last week in response to Foxs motion to dismiss, arguing that cable news channels, indeed all cable content producers, are wholly unprotected by the First Amendment when that content is distributed over a third-party cable operators system. The plaintiff is misstating the law and doing so in such a way that would impair speech and press protections for everyone.

In fact, the argument if taken to its logical conclusion would strip First Amendment protections from content distributed over the public internet, including this blog post. To understand why, one needs a bit of background.

Cable television in the United States dates back to the late 1940s and early 1950s, but for the first quarter century of its existence was limited to sending terrestrial, over-the-air television broadcasts over coaxial cables to areas that, because of remoteness or mountainous terrain, suffered poor reception. Original cable programming started in the early 1970s with pioneers like Home Box Office, TBS, and the cult Z Channel in Los Angeles.

Starting at about the same time, the Federal Communications Commission began promulgating rules for cable programming, the most relevant here being requirements that cable programmers dedicate certain channels for public, educational, or government (PEG) use, or for commercial lease by unaffiliated programmers. An ongoing debate over the FCCs authority to impose these rules and efforts to both regulate and deregulate the industry led to passage of federal laws in 1984 and 1992 governing cable providers leased access and PEG channel requirements.

Prior to 1992, cable providers were prohibited from exercising any editorial control over leased or PEG channels. In the 1992 law, Congress enacted three provisions empowering cable providers to permit or restrict leased access or PEG programming that depicts sexual or excretory activities or organs in a patently offensive manner as measured by contemporary community standards (in other words, indecent content).

The first provision permitted, but did not require, cable operators to enforce rules against indecency on PEG or leased access channels. The second was an affirmative command: If an operator decided to permit indecent content over leased access channels, it had to limit it to a single channel and block access unless a cable subscriber requested access (the segregate-and-block requirement). Third, the 1992 law required the FCC to implement regulations that would allow cable operators to prohibit similar content on PEG access channels.

A coalition of cable programmers and viewers challenged parts of the law under the First Amendment. That 1996 Supreme Court case, Denver Area Telecommunications Consortium, Inc. v. FCC, is the main precedent cited by WASHLITE against Fox. The decision itself is a thicket there are six different opinions but the bottom line is that it does not stand for the proposition that cable programmers are unprotected by the First Amendment when their content is distributed by a third-party cable operator, quite the contrary.

Crucially, the majority found that the second provision, the affirmative segregate-and-block requirement for leased access, was a violation of the First Amendment rights of programmers and operators. Six justices agreed (Justices Stephen Breyer, Ruth Bader Ginsburg, Anthony Kennedy, Sandra Day OConnor, David Souter, and John Paul Stevens). Three justices Chief Justice William Rehnquist, and Justices Antonin Scalia and Clarence Thomas dissented. And WASHLITE relies on this dissent, which, as explained below, also does not hold that cable programmers are unprotected by the First Amendment.

Indeed, the action in the case was around the first and third provisions. Confusingly, two justices Kennedy and Ginsburg would have struck down all three provisions. And, three justices Thomas, Scalia, and Rehnquist would have upheld all three provisions (thus they concurred in upholding the first provision). Justice OConnor would have upheld the first and third provisions.

Accordingly, the Court upheld the first provision, which permitted but did not require cable operators to limit indecent content on leased and PEG channels, by a vote of 7-2. As noted, the second provision was struck down by a vote of 6-3. And the third provision, permitting operators to regulate indecent speech on PEG channels, was held unconstitutional by a vote of 5-4. (Justices found that, unlike leased channels, PEG programming was, one, unlikely to contain indecent content and, two, was provided for in local franchise agreements, meaning that a federally recognized right to limit indecent speech could interfere with those agreements.)

Returning to the dissent relied on by WASHLITE, as noted, Justice Thomas, joined by Chief Justice Rehnquist and Justice Scalia, would have upheld all three provisions. For the first and third provisions, Justice Thomas focused on their permissive nature that is, they did not forbid cable operators from carrying indecent content, and therefore did not burden the First Amendment rights of cable programmers (note that Justice Thomas is acknowledging that such rights exist).

Rather, the first and third provisions restored editorial discretion to the cable operator. As Justice Thomas reasoned, the cable operators were the ones harmed by the PEG and leased access requirements, like a bookstore forced to sell books published on the subject of congressional politics. This is what WASHLITE cites in their brief they note that Justice Thomas held that cable programmers do not have an affirmative right to force a private cable operator to carry content, but Justice Thomas did not say that content providers lack First Amendment rights.

Further, with respect to the second provision, the segregate-and-block requirement for cable operators who decide to carry indecent programming, far from eschewing First Amendment rights for the cable programmers, Justice Thomas expressly recognizes them. Unlike the first and third provisions, the segregate-and-block requirement clearly implicates [the cable programmers and viewers] rights, Justice Thomas wrote.

But, Justice Thomas applied strict scrutiny the highest level of constitutional scrutiny, which courts must apply to government restrictions on speech based on its content and found that the government had met its burden to show the second provision was narrowly tailored to satisfy a compelling government interest. In other words, the dissenting justices would have found that, while cable programmers have First Amendment rights, the government had a really good reason to require operators to segregate and block indecent content (to protect children) and that other means to do so, like the V-chip, were not up to the task.

At base, WASHLITE makes two legal errors. One, it relies on a dissent in a case where the majority expressly found First Amendment protections for cable programmers on a third-party cable system. Two, it misconstrues that dissent. Rather than holding that cable programmers have no First Amendment rights, the dissent would have found that in the context of indecent programming the segregate-and-block requirement satisfied the strict in theory, fatal in fact high bar of strict scrutiny analysis. WASHLITE has failed to even advance an argument as to why the same analysis should apply in the context of a state consumer protection lawsuit seeking to penalize the exercise of editorial discretion on a news channel.

Two final points are in order.

First, not only does WASHLITE misstate the law with respect to cable, it does so with respect to print and over-the-air broadcast media as well. The only medium of communication subject to slightly less First Amendment protection under current law is bunny ears broadcasting that is the use of the electromagnetic spectrum to broadcast audio and visual information over the air. This is because, one, spectrum is scarce, meaning government intervention is theoretically justified to preserve viewpoint diversity, and, two, its pervasive, meaning that, in essence, children could be inadvertently exposed to indecent speech absent government regulation.

Further, that limited exception for over-the-air broadcast is itself now controversial, as the advent of the internet, the conversion of analog signals to digital, and other technological advancements that have mitigated scarcity and allowed for greater consumer control, have undercut the legal justifications for the Red Lion and Pacifica decisions allowing government regulation of over-the-air content.

Second, and as noted, WASHLITEs argument is not limited to cable. It is effectively saying that when a news organization uses a third party to get its news to the public, the content of that news receives no First Amendment protection.

Among other things, that logic would extend to newspapers who use third-party contractors to deliver the physical paper or rely on internet service providers to distribute digital content. It would extend to syndicated radio programs who sell content to third-party broadcasters. And it would apply to the broadcast networks. ABC, CBS, the CW, FOX, and NBC would only be protected when their programming is broadcast by owned-and-operated stations. PBS wouldnt be protected at all because it doesnt own its member stations.

In fact, that logic would strip First Amendment protections from this blog post because the Reporters Committee relies on a third party to host our website and third-party internet and technology providers to transmit our speech to the public.

The COVID-19 pandemic is both a public health crisis and a profound challenge to civil liberties here and around the world. And it is a political crisis that is provoking intense and acrimonious policy debates at all points on the ideological spectrum. But that debate means that the First Amendment matters more now, not less, and regardless of who is doing the speaking or debating, it should be vigilantly protected. WASHLITEs legal theory would limit the ability of all Americans to report the news or, more broadly, speak freely on one of the most important public policy debates in generations.

The Reporters Committee regularly files friend-of-the-court briefs and its attorneys represent journalists and news organizations pro bono in court cases that involve First Amendment freedoms, the newsgathering rights of journalists and access to public information. Stay up-to-date on our work by signing up for our monthly newsletter and following us on Twitter or Instagram.

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Fox News lawsuit would strip First Amendment protection from cable news, internet - Reporters Committee for Freedom of the Press

‘Catch and Release’: Cops, Media and the Supreme Court – Crime Report

The last thing I wanted was to become the subject of a story, wrote Tara ONeill, a reporter for CTPost.com, in a story she posted last May.

ONeill, based in Bridgeport, Conn., was filming a protest on the second anniversary of the death of Jayson Negron, a 15-year-old shot by local police, when she was approached by uniformed officers and asked to move off the sidewalk.

When she told them she had every right to be on a public sidewalk, they cuffed her. She caught the whole thing on video, quoting one officer who said later he didnt know she was in the media. As she wrote, she was patted down.put into a police cruiser and taken to booking.

Arguably, police knew who ONeill was. She had been reporting on allegations of misconduct by the Bridgeport Police Department over the previous two years. Subsequently, as she put it, she was unarrested. One of her editors later speculated the arrest was retaliation and intimidation for her coverage.

Editors Note: video of her arrest, taken by ONeill, can be accessed here.

Whether true or not, such so-called catch-and-release practices by police to stop reporters, including citizen journalists, from covering legitimate events are far from rareand they are now more likely to be upheld in court, according to a forthcoming Columbia Law Review paper.

A Supreme Court ruling last year effectively leaves journalists even more vulnerable by upholding police claims that probable cause in which an officer believes a reporter is violating the lawoverrules a claim of First Amendment protection of freedom of speech, wrote the papers author, John S. Clayton, a J.D. Candidate at Columbia Law School.

Clayton, who used the Tara ONeill incident to illustrate his case, argued that the Nieves v. Bartlett ruling determined that if there were probable cause for an arrest, (like jaywalking, or failure to comply with an officers demands), it defeats any First Amendment claim against law enforcement except for certain, atypical arrests.

In other words, if a journalist or citizen journalist believes theyre being arrested because the arresting officer doesnt like their coverage or wants to intimidate them, claims that First Amendment rights were violated are null if the officer can provide a probable cause for arrest or detention.

In a synopsis of Nieves (cited by Clayton), Prof. Jud Campbell, an expert in constitutional law, said police cannot make an arrest just in retaliation for First Amendment-protected speech.

But he noted that the concept of probable cause can effectively override that defense if an officer can cite specific examples of offensive behavior, such as refusing to follow directions, or even acting in an unruly manner.

Journalists covering a mass protest could be especially vulnerable, Campbell observes.

Others media experts agree.

The concern for journalists is that almost everyone at a protest, or a similarly chaotic crowd scene, is guilty of some minor infraction, Frank D. LoMonte, the Director of the Brechner Center for Freedom of Information wrote in a Medium article.

A videographer following marchers down a busy street may be jaywalking or obstructing traffic, even by stepping off the curb for a moment.

The U.S. Press Freedom Tracker website has estimated that since 2017, over 60 journalists have been arrested, most often while covering protests. This statistic doesnt include the attacks, arrests or attempts to interfere with members of the public, acting as citizen journalists, who have used their smartphones or videos to record police shootings of unarmed civilians or arrests.

Clayton went on to argue that because of Nieves, its become increasingly difficult for a newsgatherer to prove that an officers arresting motive is to punish their exercise of free speech.

[The Supreme Court ruling allows] authorities to arbitrarily wield broad, censorial power to suppress information before it reaches the marketplace of ideas, he wrote.

Nieves now sets an ominous precedent for upholding officers who claim their actions against a journalist were the result of perceived inflammatory behavior, thereby superseding any First Amendment retaliation claim made against the police.

Clayton calls this behavior catch-and-release moving a journalist away from the scene of an event where they might witness questionable behavior by law enforcement, but without subjecting the journalist to arrest.

Clayton maintained that arresting journalists for something like standing in the wrong place during a protest allows authorities to essentially censor the media. Courts might, however, conclude that this amounts to prior restraint, a form of censorship that might produce an acceptable argument in the medias favor in court.

Frank LoMonte of the Brechner Center noted that the nature of modern mass protests reinforces the ability of law enforcement to clamp down on coverage they find objectionable.

If [a] momentary misstep is now going to justify an arrest even if the officers real motive is to suppress news coverage then the First Amendment right to gather news on the scene of a heavily policed public event becomes nearly impossible to enforce.

The ruling provides some possibilities for lower courts to still decide in favor of journalists, under the atypical arrest exception established by the Court.

Under Nieves, there are situations where law enforcement had probable cause to make arrests, but typically exercise their discretion not to do so.

Nevertheless, Clatyton argued, the ruling represents a worrying restriction on press freedom, and it may undermine some recent circuit court decisions recognizing a First Amendment right of citizens to film police and government activities.

Some of the most socially important newsgathering acts in recent years involved citizens recording police violence on cell phones, including the use of force against Eric Garner and Walter Scott, Clayton wrote.

A newsgatherer who seeks to videotape police misconduct, but cannot do so due to an arrest, is irrevocably prevented from capturing a unique set of images that might otherwise be used to hold local officials to account.

To remedy these potential injustices, Clayton maintained that courts must treat a journalists arrest as a prior restraint intended to suppress the media. It can also apply what he called speech-protective remedies to these cases, and clearly define atypical arrests.

By embracing these solutions, courts can ensure that newsgatherers like Tara ONeill who are arrested while fulfilling core First Amendment values will have a legal remedy to vindicate their rights and deter future efforts at state suppression, Clayton concluded.

The forthcoming paper can be accessed here.

This summary was prepared by TCR staff writer Andrea Cipriano

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'Catch and Release': Cops, Media and the Supreme Court - Crime Report

Lawsuits Filed to Overturn FDA Graphic Cigarette Warnings – CSPDailyNews.com

Image courtesy of the U.S. Food & Drug Administration

WASHINGTON The federal Family Smoking Prevention and Tobacco Control Act directs the FDA to issue regulations requiring new text and color graphic health warnings depicting the negative health consequences of cigarette smoking. In 2011, the FDA issued a rule requiring nine text warnings and graphic pictures to be printed on cigarette packs, cartons and advertisements.

Several cigarette manufacturers challenged this first text and graphic cigarette health warning rule in court on the grounds that the warnings violated commercial free speech protections under the First Amendment to the U.S. Constitution. In 2012, the U.S. Circuit Court of Appeals for the District of Columbia overturned these warnings as violating the First Amendment and sent the matter back to the FDA to create new warnings that comply with Constitutional standards.

On March 17, 2020, the FDA issued a new rule requiring 11 new health warnings on cigarette packs, cartons and ads, consisting of text warning statements accompanied by graphic color images. These new warnings would be required beginning June 18, 2021. Two federal lawsuits have been filed to invalidate this rule.

On April 3, 2020 R.J. Reynolds Tobacco Co., along with several other manufacturers and five retailers filed a lawsuit in the Eastern District of Texas to invalidate both the FDAs recently issued rule for new text and graphic cigarette health warnings and Congresss requirement that the FDA mandate these warnings. On May 6, the plaintiffs in this lawsuit and the FDA jointly asked the court for a 120-day extension of the effective date of the new cigarette health warnings to Oct. 16, 2021, because of the disruptive effects of the global outbreak of COVID-19 on both manufacturers and retailers and on the FDA. A decision by the federal court on extending the effective date is pending.

Also on May 6, Philip Morris USA Inc. and Sherman Group Holdings LLC filed a lawsuit in the District of Columbia against the FDA also seeking to invalidate the graphic warnings rule and Congresss requirement that the FDA mandate these warnings.

Several legal claims were made in these two lawsuits, including:

Although the graphic warnings requirements most directly impact manufacturers, who must provide the warnings on packages, cartons and advertisements, retailers need to be aware of the progress of these cases as their outcome will impact the cigarette products retailers sell.

Thomas Briant is the executive director of NATO, a tobacco retailing association based in Lakeville, Minn. Reach him at info@natocentral.org.

Get todays need-to-know convenience industry intelligence. Sign up to receive texts from CSP on news and insights that matter to your brand.

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This Week in Technology + Press Freedom: May 17, 2020 – Reporters Committee for Freedom of the Press

Heres what the staff of the Technology and Press Freedom Project at the Reporters Committee for Freedom of the Press is tracking this week.

Last Wednesday, the Senate passed an amendment to the Foreign Intelligence Surveillance Act that would addimportant protections for the news media.

The amendment, sponsored by Sens. Mike Lee (R-Utah) and Patrick Leahy (D-Vt.), would specifically expand the use of amicus curiae court-appointed experts who represent the interests of individual privacy and civil liberties in the Foreign Intelligence Surveillance Court. While current law requires the appointment of an amicus curiae only when the court is presented with a novel or significant interpretation of the law, the amendment would expand mandatory appointment to other scenarios, including the rare case that presents or involves an investigative matter involving the activities of the domestic news media. (The court could decline to appoint an amicus if it issues a finding that such an appointment would not be appropriate.)

Before the Senate vote, the Reporters Committee sent aletterto the Senate in support of the Lee-Leahy amendment. The amendment passed with broad bipartisan support, 77 to 19. It will now be added to the broader intelligence bill theUSA FREEDOM Reauthorization Act and introduced for a vote in the House of Representatives.

Another amendment, which the Reporters Committee also supported,failedby just one vote. Sponsored by Sens. Steve Daines (R-Mont.) and Ron Wyden (D-Ore.), it would have prohibited applications under the FISA business records provision that seek internet website browsing information or internet search history information.

Echoing theargumentit made inUnited States v. Carpenter the Supreme Court case that imposed a warrant requirement for more than a week of cell site location information the Reporters Committee explained in its letter that web browsing information can likewise expose sources and journalistic methods [and] can put sources jobs and lives at risk, compromise the integrity of the newsgathering process, and have a chilling effect on reporting.

Jordan Murov-Goodman

The Reporters Committee, represented by the First Amendment Amicus Brief Clinic at the UCLA School of Law, recently filed afriend-of-the-court briefin a case involving a public records request by Georgetown law schools Center on Privacy & Technologyto the New York Police Department for records regarding the departments use of facial recognition technology. The NYPD released some records but later said that certain records were mistakenly disclosed. Not only did the trial court order CPT to return some of the inadvertently disclosed records, it also prohibited the think tank from referring to or referencing the documents, which the appellate division affirmed. The Reporters Committees briefarguesthat CPT should be granted leave to appeal to the New York Court of Appeals because the order is an unconstitutional prior restraint.

TechCrunchreportedlast week that the workplace messenger app Slack has confirmed that it has started to remove metadata, including location information, from photos shared on the platform. The move could provide additional security for users such as journalists who might have to rely on the messaging service to correspond with sensitive sources.

Social media platforms continue to grapple with how to address the rapid spread of misinformation about COVID-19, with Facebook and Instagramremovinga conspiracy-focused video called Plandemic from their platforms and rejecting ads that include it. YouTube has similarly removed uploads of the video for violating Community Guidelines. Twitter alsoannouncedlast Monday that it will label and potentially remove misleading, disputed, or unverified tweets about COVID-19.

The Department of Homeland Security recentlyannouncedthat Chinese journalists working for non-American news outlets and seeking to report from the U.S. would be limited to 90-day work visas, with the possibility of extensions. Previously, DHS granted open-ended, single-entry stays to such journalists. Some have noted the change is likely a result of mounting tension between the Trump administration and China, particularly around COVID-19, that has resulted in retaliation by both countries against journalists from the other country.

Surveillance software company NSO Groups North American branch attempted to sell its phone-hacking technology to at least one U.S. police department, Vices Motherboardreported. An anonymous former employee explained to Motherboard that this technology was the same as that used by foreign governments, including Saudi Arabia in surveilling associates of murdered Washington Post Global Opinions contributing columnist Jamal Khashoggi.

Responding to public scrutiny and several lawsuits, facial recognition technology firm Clearview AIstatedthat it will terminate its contracts with private companies, instead selling its software solely to government and law enforcement customers. Lawyers representing plaintiffs in at least one lawsuit, as well as privacy advocates, say the companys move does not go far enough, leaving in place a system that exposes nearly everyone to continued privacy harms.

Smart reads

The Washington Post Magazine published anadapted excerptfrom reporter Barton Gellmans upcoming book about how he met National Security Agency whistleblower Edward Snowden and broke the news about the U.S. surveillance program.

The MIT Technology Review has developed aCovid Tracing Trackerdatabase to increase public awareness of the privacy practices of different apps purporting to assist in contact tracing.

Gif of the Week:This weeks newsletter is just the surveillance-heavy newsletter.

Like what youve read?Sign up to get This Week in Technology + Press Freedom delivered straight to your inbox!

The Technology and Press Freedom Project at the Reporters Committee for Freedom of the Press uses integrated advocacy combining the law, policy analysis, and public education to defend and promote press rights on issues at the intersection of technology and press freedom, such as reporter-source confidentiality protections, electronic surveillance law and policy, and content regulation online and in other media. TPFP is directed by Reporters Committee Attorney Gabe Rottman. He works with Stanton Foundation National Security/Free Press Fellow Linda Moon and Legal Fellows Jordan Murov-Goodman and Lyndsey Wajert.

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This Week in Technology + Press Freedom: May 17, 2020 - Reporters Committee for Freedom of the Press

Alleged threats against Norman Mayor Breea Clark protected by First Amendment, Norman Police Department determines – The Oklahoma Daily

The Norman Police Department said it determined the communication Norman Mayor Breea Clark reported Thursday morning doesnt constitute a direct threat to the public or to Clark and was protected by the First Amendment.

The Norman Police Department said in a press release Friday afternoon that it received information regarding an alleged threat posted to the Facebook group Reopen Norman referencing Clark Thursday morning.

According to the Oklahoman, the police department began an investigation into the social media post after Clark reported a Facebook post that read Mayor (expletive), needs to be pulled out of office and tried on the court house lawn the problem with politicians, they dont get hung in public anymore #bringbackpublichangings!

The comment was later attributed to Eddie Zaicek, a police officer in Lexington, according to the Oklahoman, although he denied posting it, saying his account had been hacked.

According to the release, involved parties were cooperative throughout the investigation, and the individual responsible for the comment admitted to writing and posting it on social media. Investigators found no indication of a direct threat to public safety.

Investigators presented the case to the Cleveland County district attorneys office, which determined charges couldnt be filed.

According to the release, based on Oklahoma State Statute, investigators found that the communication was not a direct threat and was actually protected by the First Amendment.

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Alleged threats against Norman Mayor Breea Clark protected by First Amendment, Norman Police Department determines - The Oklahoma Daily

‘We’re concerned that our First Amendment rights are being trampled underfoot’ | Winston-Salem pastor files lawsuit against Governor Cooper -…

The lawsuit alleges the Governor's executive orders preventing gatherings of more than ten people violate the Constitution.

Almost a full week into Phase 1 of Governor Roy Cooper's reopening plan, some religious leaders in our state are suing the Governor over his executive order.

They say the rules around church services violate the Constitution, and they should be allowed to worship indoors.

During the coronavirus pandemic, churches and houses of worship have had to adapt - from streaming services online to holding drive-in services in the parking lot.

While many say they understand the Governor's plea to keep services remote or outside, others - like Pastor Ronnie Baity - believe this is an infringement on their rights.

"The greatest institution in America has been put on ice," said Baity at a press conference in Raleigh Thursday, "It's time that we go back, under the right sanitary conditions."

Those strong feelings have led to a lawsuit against the Governor, filed by Baity and his religious organization Return America. The pastor of Berean Baptist Church in Winston-Salem believes the executive order banning indoor gatherings of more than 10 people violates the first amendment.

"The church house is not an incubator for the disease. It's everywhere. And we believe that as we exercise these sanitary conditions that our chances here are no worse than they are at Walmart," he said in an interview Thursday.

"You've got to follow your conscience. You've got to do what you think is best for you," he said, "That's precisely what we are doing. We are concerned that our First Amendment rights are being trampled underfoot."

Meantime, Governor Cooper urged congregations to consider whether indoor services are the right thing to do right now.

"We need North Carolinians to keep doing what they know protects them from this pandemic," he said in a press conference.

Over at Lebanon Baptist Church in Greensboro, Pastor Matt Smith says that means respecting the state's orders.

Last weekend, his church held Sunday service in the parking lot and live-streamed it for folks at home.

"We havent felt the need to really press the issue at this point," he said, "We feel like a big part of church is that we gather together, and we want to do that as soon as we possibly can. Were doing it in the best ways that we can right now.

"But we believe the church is much more than that. We believe the church has continued to be for these past several weeks - to be alive and well and continue to be the hands and feet of Christ in our community."

This Sunday, Pastor Smith says they're holding service on the ball field at Lebanon Baptist.

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'We're concerned that our First Amendment rights are being trampled underfoot' | Winston-Salem pastor files lawsuit against Governor Cooper -...

New York Churches Dont Want To Be Among The Last To Reopen – WSKG.org

ALBANY, NY (WSKG) Parts of New York state are gradually reopening, with western New York authorized on Monday to join five other regions of the state and begin the first of a four-phase process. The Capital Region will be allowed to begin reopening on Tuesday.

Gov. Andrew Cuomo also said Monday that churches, synagogues, mosques and other houses of worship are not permitted to reopen, though, until phase 4 is reached. Religious leaders are asking the state for more guidance, and whether if they practiced safe social distancing they could open sooner than that.

Cuomo, at his daily coronavirus briefing, said because many religious services involve large gatherings, they cant safely restart until phase four. Speaking in Buffalo, he compared a large worship event to the crowded sightseeing boats now banned in Niagara Falls.

Its the same thing, its all jammed boats, jammed temples, jammed churches, Cuomo said. The gathering is the issue.

He said the first COVID-19 hot spot in New York stemmed from a religious gathering in New Rochelle.

But it could be several weeks, or even months, in some parts of the state hit hardest by the virus, before phase four of a reopening is reached.

Dennis Poust is with the Catholic Conference, which represents New Yorks Catholic cardinals and bishops. Speaking via Skype, he said houses of worship were never formally closed by the state, and Catholic churches are still open for private prayer or to light a candle.

But he said Catholic leaders decided to curtail public services as the COVID-19 pandemic raged in New York. Now, he says they are thinking of ways to reopen with safe social distancing and other precautions, and believes they can do that sooner than in phase four.

The governor seemed to be saying is to reopen like normal would be a phase four situation, but we have no intention of reopening like normal, said Poust. We are going to have to put strict limits in terms of capacity in every church, and all sorts of restrictions.

The Rev. Jason McGuire, with the Christian lobbying group New Yorkers for Constitutional Freedoms, said evangelical church leaders understand that there is a state of emergency in New York because of the virus. But, he said, state officials should work with religious leaders to find a balance that allows church services to resume.

And thats what this state government has failed to do, McGuire said. Its good at restricting religious liberty, but hasnt done so in the least restrictive means possible.

McGuires group is sending a letter to Cuomo this week, saying the weeks-long shutdown has taken a toll on the evangelical communities. He asked why churches cant open when grocery stores and now garden stores are allowed to reopen and have several dozen people in the building at a time.

He said even the governors daily press briefings often contain as many people, at safe social distances, as a small rural church might see on a typical Sunday.

Im watching these daily press conferences that are coming out of Albany and all across the state, and theres 15 or so different members of the press there, staff people, McGuire said. There is a First Amendment right to free press, but the right to worship in our buildings is now being denied to us.

McGuire has asked if churches could rent out drive-in movie theaters, which have been permitted to reopen, to hold services on Sunday mornings, but has received no answer. He said the worry is that some churches could go ahead and reopen anyway without any guidelines in place.

A reporter asked Cuomo on Sunday about permission to celebrate the orthodox Jewish holiday of Shavuot, which begins on May 28, if it could be done in very small groups. He said he and his team are considering whether to permit smaller religious gatherings and ceremonies for the upcoming Memorial Day holiday on May 25.

I think we can, Cuomo said. Thats what we are talking through.

He said he hopes to announce a decision soon.

Poust said when parishioners do return for Mass, it will be a different experience. Communion can be given, but only in the receivers hand, not by mouth, and the priest will have to sanitize their hands between each person. A communal cup offered as part of the sacrament would have to be curtailed for now. And there wont be any singing.

We dont want to spread germs, and you spread germs by singing, said Poust, who added there will be no choirs and people will be wearing masks, making it difficult to sing.

On Monday, church services in Italy were permitted to resume. Pope Francis reopened St. Peters Basilica and held a private Mass in a side chapel, and some visitors had their temperatures taken when they entered and were told to sit 5 feet apart and wear masks.

Houses of worship can also open in the neighboring state of Massachusetts as of Monday, if they observe strict social distancing guidelines. Outdoor services are encouraged.

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New York Churches Dont Want To Be Among The Last To Reopen - WSKG.org

How a question of process almost killed a critical bill to help Wyoming’s unemployed workers – Casper Star-Tribune Online

Even though Wyoming already has numerous liability laws on the books to protect business owners seemingly rendering such an amendment unnecessary members of the Senate saw the amendment as a simple ask. The Wyoming Legislature had already acted on bills in the past to protect the owners of ski resorts in similar instances, for example, and a similar bill on the books could potentially help to dissuade opportunistic attorneys from pursuing frivolous lawsuits against business owners trying to save their businesses while acting in accordance with state and local public health orders. It would increase business confidence, Driskill said, keeping business owners doing their best to follow the law from being punished for simply trying to keep themselves afloat.

For members of the House, even a compromise appeared to be a non-starter. Many believed the legislation could potentially take away ones First Amendment right to petition their government through the courts and felt they were being forced to cave on a flawed bill, where the numerous good parts of the legislation were being held hostage by the bad parts.

Eventually, members of the House negotiating team eventually supported a toned-down version of the amendment drafted by Sen. Tara Nethercott, a Cheyenne attorney who was similarly reluctant to support the deal.

However, when the bill was brought back to the House for final approval late Saturday afternoon, members eviscerated the amendment and the process to introduce it in nearly two hours of debate, casting doubt that the legislation would pass. House Speaker Pro Tempore Albert Sommers, R-Pinedale, said the amendment was potentially unconstitutional, saying that rolling over would be a black mark on the House of Representatives. Rep. Charles Pelkey, D-Laramie, who originally planned on voting for the bill, later announced he would be flipping his vote, calling the business immunity provisions unnerving a feeling shared by several other attorneys in the House. Others expressed anxiety about the possibility of leaving a bad law on the books for the six weeks until the Legislature meets in a second special session later this year. One other Democrat, Rep. Sara Burlingame, D-Cheyenne, also joined Pelkey in opposing the bill, citing similar concerns.

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How a question of process almost killed a critical bill to help Wyoming's unemployed workers - Casper Star-Tribune Online

North Carolina churches allowed to have indoor services, win restraining order against religious restrictions – WXII12 Winston-Salem

The United States District Court is allowing North Carolina churches to hold indoor services by granting a temporary restraining order on religious gathering restrictions. The plaintiffs filed a complaint, saying Gov. Roy Cooper's Executive Order 138 concerning COVID-19 and worship services of more than 10 people being outdoors "violates the Free Exercise Clause of the First Amendment."Multiple plaintiffs on the court ruling are from the Triad. Berean Baptist Church and its pastor, Dr. Ronnie Baity, are located in Winston-Salem along with Return America.Related: Winston-Salem pastor named in federal suit reacts to temporary lifting of church gathering restrictions Judge James C. Denver III agreed with the plaintiffs, who also stated the limits treated churches differently from other retailers and other secular activities.In the filing, the judge ruled:"There is no pandemic exception to the Constitution of the United States or the Free Exercise Clause of the First Amendment. Plaintiffs have demonstrated that they are likely to succeed on the merits of their Free Exercise claim concerning the assembly for religious worship provisions in Executive Order 138, that they will suffer irreparable harm absent a temporary restraining order, that the equities tip in their favor, and that a temporary restraining order is in the public interest. Thus, having considered the entire record and governing law, the court grants plaintiffs' motion for a temporary restraining order." Related: Triad churches begin drive-in services during phase 1 of reopeningNorth Carolina Speaker Tim Moore tweeted, saying the ruling "recognizes 1st Amendment rights deserve more protection, not less." North Carolina Gov. Roy Cooper's spokesperson responded with a statement:"We don't want indoor meetings to become hot spots for the virus and our health experts continue to warn that large groups sitting together inside for long periods of time are much more likely to cause the spread of COVID-19. While our office disagrees with the decision, we will not appeal, but instead urge houses of worship and their leaders to voluntarily follow public health guidance to keep their members safe." "This court does not doubt that the Governor is acting in good faith to lessen the spread of COVID-19 and to protect North Carolinians," the ruling noted. "'But restrictions inexplicably applied to one group and exempted from another do little to further these goals and do much to burden religious freedom.'" The full court ruling can be read here.

The United States District Court is allowing North Carolina churches to hold indoor services by granting a temporary restraining order on religious gathering restrictions.

The plaintiffs filed a complaint, saying Gov. Roy Cooper's Executive Order 138 concerning COVID-19 and worship services of more than 10 people being outdoors "violates the Free Exercise Clause of the First Amendment."

Multiple plaintiffs on the court ruling are from the Triad. Berean Baptist Church and its pastor, Dr. Ronnie Baity, are located in Winston-Salem along with Return America.

Related: Winston-Salem pastor named in federal suit reacts to temporary lifting of church gathering restrictions

Judge James C. Denver III agreed with the plaintiffs, who also stated the limits treated churches differently from other retailers and other secular activities.

In the filing, the judge ruled:

"There is no pandemic exception to the Constitution of the United States or the Free Exercise Clause of the First Amendment. Plaintiffs have demonstrated that they are likely to succeed on the merits of their Free Exercise claim concerning the assembly for religious worship provisions in Executive Order 138, that they will suffer irreparable harm absent a temporary restraining order, that the equities tip in their favor, and that a temporary restraining order is in the public interest. Thus, having considered the entire record and governing law, the court grants plaintiffs' motion for a temporary restraining order."

Related: Triad churches begin drive-in services during phase 1 of reopening

North Carolina Speaker Tim Moore tweeted, saying the ruling "recognizes 1st Amendment rights deserve more protection, not less."

North Carolina Gov. Roy Cooper's spokesperson responded with a statement:

"We don't want indoor meetings to become hot spots for the virus and our health experts continue to warn that large groups sitting together inside for long periods of time are much more likely to cause the spread of COVID-19. While our office disagrees with the decision, we will not appeal, but instead urge houses of worship and their leaders to voluntarily follow public health guidance to keep their members safe."

"This court does not doubt that the Governor is acting in good faith to lessen the spread of COVID-19 and to protect North Carolinians," the ruling noted. "'But restrictions inexplicably applied to one group and exempted from another do little to further these goals and do much to burden religious freedom.'"

The full court ruling can be read here.

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North Carolina churches allowed to have indoor services, win restraining order against religious restrictions - WXII12 Winston-Salem

State coronavirus shutdowns and the Constitution – Powell Tribune

Mark Klaassen

By Mark Klaassen

Over the past two months, the nation has engaged in unprecedented shutdowns in an effort to contain the outbreak of COVID-19. After many weeks of economically crippling restrictions and stay-at-home orders, citizens are beginning to question the justification for these measures and whether continued enforcement unreasonably infringes on important constitutional rights and liberties. These concerns are becoming more acute now that we have a better understanding of the impact on our medical system and the economy across the nation and here in Wyoming.

There is no question that states have broad authority to exercise their police power to implement emergency public health orders to protect against an epidemic of disease. Wyoming Gov. Mark Gordon used that authority, as set forth by state statute, to restrict the size of gatherings and close various facilities and businesses, explaining that the restrictions are necessary to protect those at high risk from COVID-19 and to avoid exceeding the capacity of the health care system.

The legal framework for evaluating the constitutionality of these measures is highly deferential to the state. The Supreme Court has ruled that when faced with an epidemic, a state may implement emergency measures that limit constitutional rights so long as they have at least some real or substantial relation to the public health emergency and are not beyond all question, a plain, palpable invasion of rights secured by the fundamental law. Jacobson v. Commonwealth of Massachusetts, 197 U.S. 11, 31 (1905). In evaluating these actions, the federal government and the federal courts may consider whether the measures are arbitrary or oppressive, but may not second guess state and local leaders who enact restrictions based upon the advice of public health experts.

While the legal inquiry is deferential, the power of the state is not unlimited. If the public health authority is exercised in particular circumstances and in reference to particular persons in such an arbitrary, unreasonable manner, or goes so far beyond what was reasonably required for the safety of the public, the courts may be compelled to interfere for the protection of such persons. Jacobson, 197 U.S. at 28.

U.S. Attorney General William Barr has recently issued a memorandum directing the Department of Justice to monitor state orders across the country to ensure they do not unduly infringe on constitutional rights and civil liberties of individual citizens, such as the free exercise of religion and freedom of speech. Consistent with that direction, the department has filed statements of interest in support of private litigants in two cases one in Mississippi and the other in Virginia that involve potential infringement of First Amendment religious free exercise rights. The state health orders at issue in these cases appeared to subject religious organizations to less favorable treatment than similarly situated organizations, implicating a heightened level of constitutional scrutiny.

Although we are actively monitoring for potential constitutional violations, including here in Wyoming, the department is being cautious not to unduly interfere or second-guess the judgment of the various states when it comes to public health. We recognize the legitimate role for the states in responding to the challenges posed by COVID-19. However, federal deference does not prevent private citizens from expressing their views or from pursuing individual legal actions for redress, as they deem necessary.

Precisely where the line exists between a valid exercise of emergency public health authority and one that is arbitrary or unreasonably infringes on individual rights is not always clear. Context matters, and courts will determine these questions based on the facts and circumstances of individual cases. Without bright lines to guide us, we rely on the wisdom and restraint of our elected leaders to carefully evaluate and make decisions based not just on the best available public health guidance, but also the economic, social, moral and constitutional implications of their actions.

The current pandemic is truly an unprecedented test of our ability to balance public health with the need to preserve constitutional rights and economic livelihood. These are difficult decisions to make, and require our leaders to confront hard truths about the limits of our ability to reasonably mitigate COVID-19 risks while still functioning as a free and prosperous society.

My hope is we continue to show signs of improvement and are able to proceed through the phases of re-opening proposed by Gov. Gordon. In the meantime, my office will monitor the situation in coordination with our state counterparts to ensure that rights under the Constitution are not unduly infringed.

Here in Wyoming, we pride ourselves in our rugged individualism and determination. We face challenges with common sense and a willingness to do what needs to be done. Let us hope our response to this virus is no exception.

(Mark Klaassen is United States Attorney for the District of Wyoming. He is based in Cheyenne.)

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State coronavirus shutdowns and the Constitution - Powell Tribune

Precision Medicine Informs Cost-Effective Heart Disease Treatments – HealthITAnalytics.com

May 18, 2020 -Using precision medicine approaches to tailor heart disease therapies could lead to more cost-effective treatments and improved patient outcomes, according to a study led by researchers at the University of Alabama at Birmingham (UAB).

Patients who experience a heart attack have sharply reduced blood flow in coronary arteries, as well as a high risk of heart failure or death. Coronary angioplasty, a procedure to open narrowed or blocked arteries in the heart, and percutaneous coronary intervention (PCI) can restore blood flow to minimize heart damage. These procedures reduce the risk of subsequent major adverse cardiovascular events (MACE), which include heart attacks, strokes, or death.

After these procedures, providers have to make a treatment decision. After PCI, all patients receive two antiplatelet agents for up to one year. The most commonly used antiplatelet combination after PCI is aspirin and clopidogrel. Clopidogrel is converted to its active form by an enzyme called CYP2C19, but patients respond to this treatment differently depending on their genetic makeup.

Over 30 percent of people have loss-of-function variants in the CYP2C19 gene that decreases the effectiveness of clopidogrel. These patients may not get the full benefit of clopidogrel, which would increase their risk of MACE. The FDA recommends that providers consider different treatments for these individuals, such as prasugrel or ticagrelor, to replace clopidogrel.

In 2018, UAB and researchers at nine universities across the US showed that patients with loss-of-function variants who were treated with clopidogrel had elevated risks. The study revealed that there was a twofold risk of MACE in PCI patients, and a threefold risk for MACE among patients with acute coronary syndrome who received PCI, as compared to patients prescribed prasugrel or ticagrelor instead of clopidogrel.

While prasugrel and ticagrelor are not influenced by loss-of-function variants and can substitute for clopidogrel, these drugs are much more costly and can bring a higher risk of bleeding.

Using this real-world data, the research team set out to conduct an economic analysis of the best treatments for heart disease patients. The study compared three main strategies: treating all patients with clopidogrel, treating all patients with ticagrelor, and genotyping all patients and using ticagrelor in those with loss-of-function variants.

The group considered differences in event rates for heart attacks and stent thrombosis in patients receiving clopidogrel versus ticagrelor versus genotype-guided therapy, during the one-year period following PCI. They also considered medical costs from events like admissions, procedures, medications, clinical visits, and genetic testing. The study used an economic measure known as the quality-adjusted life year (QALY).

First, we looked at which strategy provided the highest QALY, Limdi said. The QALY is the gold standard for measuring benefit of an intervention in our case, genotype-guided treatment compared to treatment without genotyping. Universal ticagrelor and genotype-guided antiplatelet therapy had higher QALYs than universal clopidogrel so those are the best for the patient.

Researchers then analyzed whether those interventions that have higher QALYs were also reasonable from a cost perspective, which includes a payers or patients willingness to pay.

In our case, the payor would recognize that ticagrelor is more expensive than clopidogrel $360 per month vs. $10 per month and there is a $100 cost for each genetic test, Limdi said. So, from the payor perspective, the more effective strategy (one with a higher QALY) if more expensive (higher cost) would have to lower the risks of bad outcomes like heart attacks and strokes for the gains in QALY that are at, or below, the willingness-to-pay threshold.

A measure called incremental cost-effectiveness ratios (ICERs) assesses the incremental cost of the benefit, or improvement in QALY. In the US, a treatment is considered cost-effective if its associated ICER is at or below the willingness-to-pay threshold of $100,000 per QALY.

In our assessment, the two strategies with the highest QALY had very different ICERs, Limdi said. The genotype-guided strategy was cost-effective at $42,365 per QALY. Universal ticagrelor was not; it had an ICER of $227,044 per QALY.

The study results demonstrate the effectiveness of genotyping and precision medicine strategies for tailoring treatments and improving patient outcomes.

We showed that tailoring antiplatelet selection based on genotype is a cost-effective strategy, said Nita Limdi, PharmD, PhD. Support is now growing to change the clinical guidelines, which currently do not recommend genotyping in all cases. Evidence like this is needed to advance the field of precision medicine.

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Precision Medicine Informs Cost-Effective Heart Disease Treatments - HealthITAnalytics.com

Colonizing Mars may require humanity to tweak its DNA – Space.com

If humanity is ever going to settle down on Mars, we may need to become a little less human.

Crewed missions to Mars, which NASA wants to start flying in the 2030s, will be tough on astronauts, exposing them to high radiation loads, bone-wasting microgravity and other hazards for several years at a time. But these pioneers should still be able to make it back to Earth in relatively good nick, agency officials have said.

It might be a different story for those who choose not to come home, however. If we want to stay safe and healthy while living permanently on Mars, or any other world beyond our home planet, we may need to make some tweaks to our species' basic blueprint, experts say.

Related: Space radiation threat to astronauts explained (infographic)

Genetic engineering and other advanced technologies "may need to come into play if people want to live and work and thrive, and establish their family, and stay on Mars," Kennda Lynch, an astrobiologist and geomicrobiologist at the Lunar and Planetary Institute in Houston, said on May 12 during a webinar hosted by the New York Academy of Sciences called "Alienating Mars: Challenges of Space Colonization."

"That's when these kinds of technologies might be critical or necessary," she said.

Genetic enhancement may not be restricted to the pages of sci-fi novels for much longer. For example, scientists have already inserted genes from tardigrades tiny, adorable and famously tough animals that can survive the vacuum of space into human cells in the laboratory. The engineered cells exhibited a greater resistance to radiation than their normal counterparts, said fellow webinar participant Christopher Mason, a geneticist at Weill Cornell Medicine, the medical school of Cornell University in New York City.

NASA and other space agencies already take measures to protect their astronauts physically, via spacecraft shielding, and pharmacologically via a variety of medicines. So, it's not a huge conceptual leap to consider protecting them genetically as well, provided that these measures are proven to be safe, Mason said.

"And are we maybe ethically bound to do so?" he said during the webinar. "I think if it's a long enough mission, you might have to do something, assuming it's safe, which we can't say yet."

Tardigrades and "extremophile" microbes, such as the radiation-resistant bacterium Deinococcus radiodurans, "are a great, basically natural reservoir of amazing traits and talents in biology," added Mason, who has been studying the effects of long-term spaceflight on NASA astronaut Scott Kelly. (Kelly spent nearly a year aboard the International Space Station in 2015 and 2016.) "Maybe we use some of them."

Harnessing these traits might also someday allow astronauts to journey farther than Mars, out to some even more exotic and dangerous cosmic locales. For instance, a crewed journey to the Jupiter moon Europa, which harbors a huge ocean beneath its icy shell, is out of the question at the moment. In addition to being very cold, Europa lies in the heart of Jupiter's powerful radiation belts.

"If we ever get there, those are the cases where the human body would be almost completely fried by the amount of radiation," Mason said. "There, it would be certain death unless you did something, including every kind of shielding you could possibly provide."

Genetic engineering at least lets us consider the possibility of sending astronauts to Europa, which is widely regarded as one of the solar system's best bets to harbor alien life. (The Jovian satellite is a high priority for NASA's robotic program of planetary exploration. In the mid-2020s, the agency will launch a mission called Europa Clipper, which will assess the moon's habitability during dozens of flybys. And Congress has ordered NASA to develop a robotic Europa lander as well, though this remains a concept mission at the moment.)

Related: The 6 most likely places to find alien life

Genetic engineering almost certainly won't be restricted to pioneering astronauts and colonists. Recent advances in synthetic biology herald a future in which "designer microbes" help colonists establish a foothold on the Red Planet, Lynch said.

"These are some of the things that we can actually do to help us make things we need, help us make materials to build our habitats," she said. "And these are a lot of things that scientists are researching right now to create these kinds of things for our trip to Mars."

Some researchers and exploration advocates have even suggested using designer microbes to terraform Mars, turning it into a world much more comfortable for humans. This possibility obviously raises big ethical questions, especially considering that Mars may have hosted life in the ancient past and might still host it today, in subsurface lakes or aquifers. (Permanently changing our own genomes for radiation protection or any other reason may also strike some folks as ethically dubious, of course.)

Most astrobiologists argue against terraforming Mars, stressing that we don't want to snuff out or fundamentally alter a native ecosystem that may have arisen on the Red Planet. That would be both unethical and unscientific, Lynch said.

After all, she said, one of the main reasons we're exploring Mars is to determine if Earth is the only world to host life.

"And how can we do that if we go and change the planet before we go and find out if life actually was living there?" Lynch said.

Mike Wall is the author of "Out There" (Grand Central Publishing, 2018; illustrated by Karl Tate), a book about the search for alien life. Follow him on Twitter @michaeldwall. Follow us on Twitter @Spacedotcom or Facebook.

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Colonizing Mars may require humanity to tweak its DNA - Space.com

Complement genes add to sex-based vulnerability in lupus and schizophrenia – Newswise

Newswise BIRMINGHAM, Ala. Variants in a gene of the human immune system cause men and women to have different vulnerabilities to the autoimmune diseases lupus and Sjgrens syndrome, according to findings published in the journal Nature. This extends recent work that showed the gene variants could increase risk for schizophrenia.

The gene variants are a member of the complement system, a cascade of proteins that help antibodies and phagocytic cells remove damaged cells of a persons own body, as well as an infection defense that promotes inflammation and attacks pathogens. Normally the complement system keeps a person healthy in the face of pathogens; it also helps cart away the debris of damaged human cells before the body can mount an autoimmune attack. Now complement gene variants apparently play a contributing role in the diseases systemic lupus erythematosus, Sjgrens syndrome and schizophrenia.

It had been known that all three illnesses had common genetic associations with a section of the human chromosome called the major histocompatibility complex, or MHC. This region on chromosome 6 includes many genes that regulate the immune system. However, making an association with a specific gene or with the mutational variants of a specific gene that are called alleles has been difficult, partly because the MHC on human chromosome 6 spans three million base-pairs of DNA.

The Nature paper is a collaboration of 22 authors at 10 institutions in the United States and one in England, along with many members of a schizophrenia working group. Robert Kimberly, M.D., professor of medicine at the University of Alabama at Birmingham and director of the UAB Center for Clinical and Translational Science, is a co-author of the research, which was led by corresponding author Steven McCarroll, Ph.D., assistant professor of genetics at Harvard Medical School.

The identified alleles are complement component 4A and 4B, known as C4A and C4B.

The research showed that different combinations of C4A and C4B copy numbers generate a sevenfold variation in risk for lupus and 16-fold variation in risk for Sjgrens syndrome among people with common C4 genotypes. Paradoxically, the same C4 alleles that previously were shown to increase risk for schizophrenia had a different impact for lupus and Sjgrens syndrome they greatly reduced risk in those diseases. In all three illnesses, the C4 alleles acted more strongly in men than in women.

For the complement proteins that are encoded by the genes for C4 and for complement component 3, or C3, both C4 protein and its effector C3 protein were present at greater levels in men than in women in cerebrospinal fluid and blood plasma among adults ages 20-50. Intriguingly, that is the age range when the three diseases differentially affect men and women for unknown reasons. Lupus and Sjgrens syndrome affect women of childbearing age nine times more than they do men of similar age. In contrast, in schizophrenia, women exhibit less severe symptoms, more frequent remission of symptoms, lower relapse rates and lower overall incidence than men, who are affected more frequently and more severely.

Both men and women have an age-dependent elevation of C4 and C3 protein levels in blood plasma. In men, this occurs early in adulthood, ages 20-30. In women, the elevation is closer to menopause, ages 40-50. Thus, differences in complement protein levels in men and women occur mostly during the reproductive years, ages 20-50.

The researchers say sex differences in complement protein levels may help explain the larger effects of C4 alleles in men, the greater risk of women for lupus and Sjgrens, and the greater vulnerability of men for schizophrenia.

The ages of pronounced sex differences in complement levels correspond to the ages when men and women differ in disease incidence. In schizophrenia cases, men outnumber women in early adulthood; but that disparity of onset lessens after age 40. In lupus, female cases greatly outnumber male cases during childbearing years; but that difference is much less for disease onset after age 50 or during childhood. In Sjgrens syndrome, women are more vulnerable than are men before age 50.

The researchers say the differing effect of C4 alleles in schizophrenia versus lupus and Sjgrens syndrome will be important to consider in any therapeutic effort to engage the complement system. They also said, Why and how biology has come to create this sexual dimorphism in the complement system in humans presents interesting questions for immune and evolutionary biology.

Co-authors with McCarroll and Kimberly for the paper, Complement genes contribute sex-biased vulnerability in diverse illnesses, are Nolan Kamitaki, Aswin Sekar, Heather de Rivera, Katherine Tooley and Christine Seidman, Harvard Medical School, Massachusetts; Robert Handsaker and Christopher Whelan, Broad Institute of Massachusetts Institute of Technology; David Morris, Philip Tombleson and Timothy Vyse, Kings College London, London, United Kingdom; Kimberly Taylor and Lindsey Criswell, University of California-San Francisco School of Medicine; Loes Olde Loohuis and Roel Ophoff, University of California-Los Angeles; Michael Boehnke, University of Michigan; Kenneth Kaufman and John Harley, Cincinnati Childrens Hospital Medical Center, Ohio; Carl Langefeld, Wake Forest School of Medicine, North Carolina; Michele Pato and Carlos Pato, State University of New York, Downstate Medical Center; and Robert Graham, Genentech Inc., South San Francisco, California.

Support came from National Institutes of Health grants HG006855, MH112491, MH105641 and MH105653; and from the Stanley Center for Psychiatric Research.

At UAB, Kimberly holds the Howard L. Holley Research Chair in Rheumatology.

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Complement genes add to sex-based vulnerability in lupus and schizophrenia - Newswise

23andMe Is Trying to Crack the Genetic Code Behind the Coronavirus – Motley Fool

The coronavirus has swept across the globe in recent months, and companies in all sectors of the healthcare industry have stepped up to combat the pandemic. Many are now scrambling to develop a vaccine.

One of the greatest challenges facing healthcare workers on the front lines, as well as the companies working on vaccine candidates, is that COVID-19 varies so much among patients. According to a report published by the World Health Organization back in March, approximately 80 percent of those infected exhibit mild symptoms or none at all.A study published in the journal Nature Medicine found that 44% of individuals who caught COVID-19 through secondary transmission contracted the illness while the original infector was still asymptomatic.

The most recent data released from the Centers for Disease Control and Prevention shows that 60.5 per 100,000 patients require hospitalization, and death certificates show that the flu, COVID-19, or pneumonia were behind 12.8% of all U.S. deathsfrom May 4 through May 10.Over 300,000 people worldwide have died of COVID-19.

Image source: Getty Images.

DNA testing companies are rising to the occasion with the launch of numerous studies hoping to crack the genetic code behind COVID-19. Last month, one of the biggest names in the consumer genetics market, 23andMe, initiated a study into the link between genetics and COVID-19 outcomes.

Founded in 2006, 23andMe is a privately held company that offers a slew of popular direct-to-consumer genetic tests and has the power of nearly $800 million of venture capital backing behind it. While 23andMe hasn't yet made its way to the public market, prospective investors and consumers alike should still be watching this start-up and its current study closely.

Here's what you need to know.

23andMe first launched its study back in April, and hundreds of thousands of customers have participated so far through online surveys. In the initial part of its study, 23andMe surveyed customers who had tested positive for COVID-19, as well as customers who had not received a positive diagnosis.The study will also allow contributions from family members of customers who have been ill with the coronavirus. The company will use this information to assess genetic similarities and dissimilarities among critically ill patients.

Last week, 23andMe announced that it was expanding its genetic study to include up to 10,000 adults who are not 23andMe customers and who have been hospitalized for COVID-19. In 23andMe's blog post announcing the study's expansion, the company stated that its research model means it can

not only reach out to current customers, but also quickly recruit and genotype new research participants. We can then survey those participants, and conduct genetic studies at a massive scale. ... There are several questions about whether genetics may explain the differences in immune response among patients. Our study could aid in assessing differences in risk among individuals. It could also guide efforts now under way to treat the disease caused by the virus.

When 23andMe announced its expansion of the study in a blog post published May 13, it noted that more than 500,000 people have enrolled in the study thus far, and more than 7,000 of the participants have been diagnosed with COVID-19.

In the 14 years since its founding, 23andMe has received venture-capital backing from a particularly impressive and diverse group of leading technology and pharmaceutical companies. Think big names like Fidelity Management & Research Company, Sequoia Capital, Alphabet's (NASDAQ:GOOG) Google Ventures, Johnson & Johnson's(NYSE:JNJ)venture capital division, and GlaxoSmithKline (NYSE:GSK).

23andMe is in late-stage funding. Its most recent round, in January 2019, consisted of secondary market funding from angel investor and former U.S. government official Raj Luhar. Secondary market funding occurs when an individual investor buys equity in a privately held company from current investors.

There's long been talk of 23andMe entering an initial public offering. It's possible the company could be looking to secure more late-stage funding to build its momentum before going the IPO route. A 2019 report released by private investment management firm Wellington Management Company found that

companies are staying private for longer. For example, the average age to IPO for VC-backed companies increased from 4.6 years during the 1990-2001 period to 6.4 years during the 2002-2018 period. As a result, companies are often more mature when they do go public. Businesses with market capitalization below US$1 billion have decreased as a percentage of the public market, from 53% of the Russell 2000 Index in 2005 to 23% as of 31 December 2018. Amid these changes, we recognized that the late-stage growth companies were often in need of capital to accelerate growth prior to, or in lieu of, an IPO or sale.

Many thought 23andMe would IPO back in 2015 when it secured an additional $115 million in a funding round. The company has yet to announce any definite plans to go public.

It's no secret that the consumer genetics market has faced notable headwinds over the past few years, as demand for DNA testing has dropped significantly. The reason behind this decline is not certain. It could be that the early boom in consumer interest wore off, or that privacy concerns got the better of the wider market.

In January, 23andMe laid off 14% of its employees. The company was just one in a long line of venture capital-backed entities that have had to slash their workforces in recent months. For example, one of 23andMe's top competitors, Ancestry, laid off 6% of its employees in early February. Coincidentally, Ancestry has also launched a study into the genomic aspects of COVID-19, but at present is limiting participants to existing customers only.

Naturally, there have been concerns about the fiscal future of genetic services given recent reductions in consumer demand. But with this new foray into genetic research, companies like 23andMe could be well positioned to aid medical providers and businesses in establishing new protocols both during and after the coronavirus crisis. Even though the company's IPO remains uncertain, 23andMe has solid backing and could be making some big moves in the near future. Healthcare investors should find this startup definitely worth watching over the next few years.

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23andMe Is Trying to Crack the Genetic Code Behind the Coronavirus - Motley Fool

Global Molecular Diagnostics Industry 2019-2029: Genetic Disorders, Cardiovascular Disorders, Infections and Cancer – Yahoo Finance UK

Dublin, May 19, 2020 (GLOBE NEWSWIRE) -- The "Molecular Diagnostics - Technologies, Markets and Companies" report from Jain PharmaBiotech has been added to ResearchAndMarkets.com's offering.

This report describes and evaluates the molecular diagnostics technologies that will play an important role in the practice of medicine, public health, pharmaceutical industry, forensics and biological warfare in the 21st century. This includes several polymerase chain reaction (PCR)-based technologies, fluorescent in situ hybridization (FISH), peptide nucleic acids (PNA), electrochemical detection of DNA, sequencing, mitochondrial DNA, biochips, nanotechnology and proteomic technologies.

The markets for molecular diagnostics technologies are difficult to estimate. Molecular diagnostics markets overlap with markets for non-molecular diagnostic technologies in the in vitro diagnostic market and are less well defined than those for pharmaceuticals.

Molecular diagnostic markets are analyzed for 2019 according to technologies, applications and geographical regions. Forecasts are made up to 2029. A major portion of the molecular diagnostic market can be attributed to advances in genomics and proteomics. Biochip and nanobiotechnology are expected to make a significant contribution to the growth of molecular diagnostics.

The number of companies involved in molecular diagnostics has increased remarkably during the past few years. More than 1,000 companies have been identified to be involved in developing molecular diagnostics and 268 of these are profiled in the report along with tabulation of 657 collaborations. Despite the strict regulation, most of the development in molecular diagnostics has taken place in the United States, which has the largest number of companies.

Initial applications of molecular diagnostics were mostly for infections but are now increasing in the areas of genetic disorders, preimplantation screening and cancer. Genetic screening tests, despite some restrictions, is a promising area for future expansion of in vitro diagnostic market. Molecular diagnostics is being combined with therapeutics and forms an important component of integrated healthcare.

Molecular diagnostic technologies are also involved in the development of personalized medicine based on pharmacogenetics and pharmacogenomics. Currently, there has been a considerable interest in developing rapid diagnostic methods for point-of-care and biowarfare agents such as anthrax. Molecular diagnostic tests for COVID-19 are described

This was the first commercial report on this topic and published as "DNA Diagnostics" in 1995 by PJB Publications, UK. A new edition in 1997 "Molecular Diagnostics I" as well as the next edition, "Molecular Diagnostics II" in 1999, were published by Decision Resources Inc, USA. All the three versions of the reports were well received and sold widely. The report has been rewritten several times.

Key Topics Covered

Part I: Technologies & ApplicationsExecutive Summary1. Introduction2. Molecular Diagnostic Technologies3. Biochips, Biosensors and Nanobiotechnology4. Proteomic Technologies for Molecular Diagnostics5. Molecular Diagnosis of Genetic Disorders6. Molecular Diagnosis of Cardiovascular Disorders7. Molecular Diagnosis of Infections8. Molecular Diagnosis of Cancer9. Molecular Diagnostics in Biopharmaceutical Industry & Healthcare10. Molecular Diagnostics in Forensic Medicine and Biological Warfare11. References

Part II: Regulations, Markets and Companies12. Ethics, Patents and Regulatory Issues13. Markets for Molecular Diagnostics14. Companies Involved in Molecular Diagnostics

For more information about this report visit https://www.researchandmarkets.com/r/4envz6

Research and Markets also offers Custom Research services providing focused, comprehensive and tailored research.

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Global Molecular Diagnostics Industry 2019-2029: Genetic Disorders, Cardiovascular Disorders, Infections and Cancer - Yahoo Finance UK

Prominent Cancer Researcher to Join DRI and Renown Health – GlobeNewswire

The Desert Research Institute (DRI) and Renown Health proudly announce the addition of Dr. Pier Paolo Pandolfi, MD, PhD, FRCP to the DRIs faculty of the Renown Institute of Health Innovation and as Director of the Institute of Cancer at Renown Health.

Reno, Nevada, May 18, 2020 (GLOBE NEWSWIRE) -- Reno, Nev. (May 18, 2020) Today, the Desert Research Institute (DRI) and Renown Health proudly announce the addition of Dr. Pier Paolo Pandolfi, MD, PhD, FRCP to the DRIs faculty of the Renown Institute of Health Innovation and as Director of the Institute of Cancer at Renown Health.

Dr. Pandolfi, a prominent cancer investigator and molecular geneticist, will build a translational cancer laboratory at DRIs campus in Reno, Nevada to expand the success of the Healthy Nevada Project (the largest, community-based population health study combining genetic, clinical, environmental and social data, and offering free genetic testing to every Nevadan) into translational medicine and create a world-class cancer research and clinical care program.

Dr. Pandolfi will divide his time between Reno and Italy, also leading a cancer research institute in his home country that will foster knowledge exchange and international cancer research collaborations between Italy and Nevada.

As a cancer researcher, my mission is to cure cancer. The Healthy Nevada Project and the combined resources of Renown Health and DRI give us access to an unprecedented amount of longitudinal data and the valuable genetic information we need to continue to improve our understanding of the molecular mechanisms of cancer and tailor approaches for treatments and cures that are unique to each individual said Dr. Pandolfi.

I am proud to take the unique resource of the Healthy Nevada Project, and use the information to accelerate our work to provide a population-level view of those factors that drive cancer, build better models and perhaps, timely new treatments. I am excited to build a strong collaborative bridge between the state of Nevada with our colleagues in Italy and across Europe, which will allow for the exchange of research fellows, physicians, scientists, and interns, added Pandolfi.

Dr. Pandolfi, a scientist whom the NIH deems outstanding, and who is leading significant contributions toward the understanding of cancer and genetics, is formerly the director of the cancer center at Beth Israel Deaconess Medical Center at Harvard Medical School in Boston and prior to that at Memorial Sloan Kettering Cancer Center in New York.

His extraordinary career in the molecular understanding of cancer has resulted in major medical breakthroughs in the treatment of solid tumors and leukemia. His foundational work in the study of critical cancer genes as models for tumor suppression has helped explain the causes of acute promyelocytic leukemia (APL) and led to the development of innovative and effective treatments and therapies for the disease.

Recognizing the need to expand the Healthy Nevada Project into a new era of translational medicine, we are very excited to welcome Dr. Pandolfi and his pioneering scientific bench-to-patient bedside approach, said Anthony Slonim, M.D., Dr.PH., FACHE, president and CEO of Renown Health and co-founder of the Renown Institute for Health Innovation and the Healthy Nevada Project. Dr. Pandolfis arrival in Nevada represents a significant milestone for all of us, especially those of us who are cancer survivors. Nearly 4 in 10 of us will be diagnosed with cancer, the second-leading cause of death in the US. Dr. Pandolfi understands how genomics provides new tools for the prevention and early detection of many cancers.

Through the Healthy Nevada Project, 50,000 Nevadans volunteered their genetic information. Dr. Pandolfi will use the insights gained during the first two phases of the Healthy Nevada Project to plan future research.

Dr. Pandolfi brings with him to Nevada, a prestigious National Institutes of Health (NIH), National Cancer Institute Outstanding Investigator award. This grant provides stable, long-term research funding to support the research activities of the Renown Institute of Health Innovation.

Dr. Pandolfi will also serve as Director of the Renown Institute for Cancer and further a goal to bring world-class, exceptional cancer care to Nevada. He will lead efforts to streamline, standardize, and personalize relationships at every point in the cancer care continuum screening, diagnosis, treatment, and the care provided for survivors as well as those at the end of life. In addition, Dr. Pandolfis strong connections with the research community facilitate matching Renown patients to the right clinical trials, another example of Renowns position at the leading edge of treatment while developing the cancer care of the future.

The study of human health and its connection to our environment has always had a place in DRIs mission and research activity, said Kumud Acharya, Ph.D., Interim President of DRI. We are proud to welcome Dr. Pandolfi to Nevada and we are thankful for this extraordinary opportunity to meaningfully expand our health sciences research capacity to serve Nevada, together with our partners at Renown Health.

A native of Rome, Dr. Pandolfi received his MD in 1989 and Ph.D. in 1995, both from the University of Perugia, Italy. He completed his post-graduate work at the Royal Postgraduate Medical School, University of London, before joining the faculty of Memorial Sloan-Kettering Cancer Center and the Weill Graduate School of Medical Sciences at Cornell University in New York in 1994.

He is the author of more than 450 peer-reviewed research papers and the recipient of more than 30 awards and honors, including the Leukemia and Lymphoma Society of America Stohlman Scholar Award; the Weizmann Institute of Science: Sergio Lombroso Prize for Cancer Research; the William and Linda Steere Foundation Award; and the prize for Scientific Excellence in Medicine from the American-Italian Cancer Foundation. He has also been awarded the Fondazione Cortese International Award; the Prostate Cancer Foundation Creativity Award; and the Guido Venosta Award for Cancer Research.

In 2006, Dr. Pandolfi was elected as a member of the American Society for Clinical Investigation and the American Association of Physicians and in 2007 became a member of the European Molecular Biology Organization. In 2015, Dr. Pandolfi was Knighted by the Republic of Italy, receiving the Officer of the Order of the Star of Italy by the President of the Italian Republic. More recently, Dr. Pandolfi has been elected Fellow of the American Association for the Advancement of Science (AAAS) in 2017 and Fellow of the Royal College of Physicians of London in 2018.

For more about the Renown Institute for Health Innovation at DRI please visit http://www.dri.edu/renown-ihi/.

The Renown Institute for Health Innovation is a collaboration between Renown Health a locally governed and locally owned, not-for-profit integrated healthcare network serving Nevada, Lake Tahoe, and northeast California; and the Desert Research Institute a recognized world leader in investigating the effects of natural and human-induced environmental change and advancing technologies aimed at assessing a changing planet. Renown IHI research teams are focused on integrating personal healthcare and environmental data with socioeconomic determinants to help Nevada address some of its most complex environmental health problems; while simultaneously expanding the states access to leading-edge clinical trials and fostering new connections with biotechnology and pharmaceutical companies.

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Prominent Cancer Researcher to Join DRI and Renown Health - GlobeNewswire

Research Roundup: HIV vaccination, diabetes two-in-one injection, hybrid fish genetics – The Stanford Daily

Each week, The Dailys Science & Tech section produces a roundup of the most exciting and influential research happening on campus or otherwise related to Stanford. Heres our digest for the week of May 1016.

A new vaccine type to prevent HIV infections

A new vaccination can provide enhanced and sustained protection against the HIV virus in rhesus macaque monkeys, a study published on May 11 in Nature Medicine found. The research might also help immunologists create a vaccine against the coronavirus and other diseases.

Most vaccines aim at stimulating serum immunity by raising antibodies to the invading pathogen, Bali Pulendran, professor of pathology and microbiology and immunology, told Stanford Medicine News. This vaccine also boosted cellular immunity, the mustering of an army of immune cells that chase down cells infected by the pathogen. We created a synergy between these two kinds of immune activity.

The adaptive immune response consists of two parts: serum immunity, including B-cells which secrete antibodies, and cellular immunity, including T-cells that find infected bodily cells and destroy them. The findings suggest vaccinations that stimulate both arms of the adaptive immune response can protect rhesus macaques from initial viral HIV infection.

These results suggest that future vaccination efforts should focus on strategies that elicit both cellular and neutralizing-antibody response, which might provide superior protection against not only HIV but other pathogens such as tuberculosis, malaria, the hepatitis C virus, influenza and the pandemic coronavirus strain as well, Pulendran told Stanford Medicine News.

Combination shot of insulin and amylin for diabetics

A combined two-in-one injection consisting of insulin and amylin may help diabetics better control their blood sugar levels, a study published on May 11 in Nature Biomedical Engineering found.

Previously, insulin and amylin a hormone that works with insulin to lower blood sugar levels more effectively than insulin alone could only be injected in two separate shots. Patients who have taken both drugs separately lose weight and have better control over their blood sugar levels. When combined, the drugs were too unstable for a single syringe.

Taking that second injection with the insulin shot is a real barrier for most patients, materials science and engineering assistant professor Eric Appel told Stanford News. Our formulation would allow them to be given together in a single injection or in an insulin pump.

The researchers developed a protective coating called cucurbituril-PEG that surrounds the insulin and amylin, allowing both to coexist in a single shot. The findings suggest the coating increases stability, promoting the drug shelf life.

Were excited about the results to say the least, Appel told Stanford News.

Genetic evolution of hybrid populations

Scientists have identified the cause of melanoma in hybrid fish in Mexico, a study published on May 14 in Science reports.

The highland swordtails and sheepshead swordtails have interbred for many generations and are native to Mexico, creating a population of hybrids. Researchers have identified two genes responsible for melanoma, which often develops in the tails of the male fish.

This discovery marks only the second time a dysfunction in hybrids has been traced to a specific gene in vertebrates. Hybrid offspring of two different species typically have genetic shortcomings.

Were just realizing that hybridization affects species all across the tree of life, including our own species many of us carry genes from Neanderthals and Denisovans, biology assistant professor Molly Schumer told Stanford News. Understanding hybridization and the negative and positive effects that can come from genes that have moved between species is important in understanding our own genomes and those of other species with which we interact.

The findings suggest the genes cd97 and xmrk are responsible for causing melanoma in the fish hybrids.

When I started my PhD in 2011, it was really not accepted that hybridization was common in animals. The best-known examples were mules and fruit flies. Its been such a massive shift and a fun time to be working on this question, Schumer told Stanford News. What weve arrived at now is the best kind of project in science: one that raises way more questions than answers and spins you off in a bunch of different directions.

Contact Derek Chen at derekc8 at stanford.edu.

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Research Roundup: HIV vaccination, diabetes two-in-one injection, hybrid fish genetics - The Stanford Daily

Singapore researches discover specific gene linked to Asian Lung Cancer – BSA bureau

New data on East Asian populations will guide researchers and clinicians to develop novel therapeutic strategies tailored to individual lung cancer patients

Singapore scientists have completed one of the largest comprehensive genome studies of Asian lung adenocarcinoma (LUAD). Findings from this landmark study, which were published in February 2020s issue of Nature Genetics, are expected to contribute to the development of personalised medicine for lung cancer treatment and prevention. The study was led by scientists from A*STARs Genome Institute of Singapore (GIS), in collaboration with the National Cancer Centre Singapore (NCCS), and the Lung Cancer Consortium Singapore (LCCS).

Worldwide, LUAD is the most common type of lung cancer, and is responsible for over one million deaths annually. It differs markedly between Asians and Europeans as Asian LUAD patients tend to be female, non-smokers, and have more mutations in an important gene known as EGFR. Past studies by GIS and NCCS have also revealed that Asian lung cancers have higher level of heterogeneity than their European counterparts.

Findings

In this study, an inter-disciplinary team of researchers built on the donated clinical samples curated by the LCCS, and sequenced and analysed the largest dataset of LUADs for East Asians (including Singaporeans who formed the majority). The study revealed that the tumour mutation landscape in Asian patients is very unique, and several new genes may be implicated in the development of lung cancers in Asians.

One striking discovery from this study is a unique sub-group of lung tumours that appears specific to Asian lung cancers. This sub-group of lung tumours is more inflammatory in Asian patients compared to European patients, and contains high amounts of immune cells. Considering the increasing use of immunotherapy in cancer treatments, this discovery may lead to a more accurate selection of lung cancer patients who can benefit from this form of treatment.

The comprehensive analyses of the genetic and molecular features of these tumours have provided researchers and clinicians with a vista to assess the fingerprint of each lung cancer tumour. Such genomic information will deepen their understanding on how individual patients might respond differently to drug treatments, thus enabling a more precise approach to treating patients in the future. Data from this study is now publicly available via the Singapore Oncology Data Portal (OncoSG) which enables integration, visualisation, analyses, and sharing of cancer genomics datasets in Singapore.

Prof Zhai Weiwei, a principal investigator at GIS and senior author of the study, noted, This study depicted a comprehensive genomic landscape of Asian LUADs, and characterised the complex ethnic differences between Asians and Europeans.

A/Prof Daniel Tan, Senior Clinician Scientist at GIS and Senior Consultant Medical Oncologist at NCCS, said, Our study highlights how such deep genetic analysis can improve our ability to predict the behaviour of lung cancers beyond traditional clinical parameters, providing new perspectives in tailoring treatment approaches.

Prof Patrick Tan, Executive Director of GIS, said, The findings may lead to new patient stratification approaches to provide better-personalised treatment options. Novel therapies may also be developed by combining existing therapies with immunotherapy targeting Asian-specific sub-groups.

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Singapore researches discover specific gene linked to Asian Lung Cancer - BSA bureau

Grant will help scientists break new ground in gene editing – Newswise

Newswise AMES, Iowa A new grant will help Iowa State University researchers develop innovative gene editing technology to better understand how human genetics affect susceptibility to disease.

The four-year, $2.8 million grant from the National Institutes of Health allows Maura McGrail, an associate professor of genetics, development and cell biology and principal investigator, and her collaborators to continue their efforts to develop gene editing technologies to model human disease in zebrafish. The research aims to build new tools to determine which genes have therapeutic potential to treat human genetic diseases that affect the cardiovascular, immune and nervous systems. Zebrafish share much of their genetic makeup with humans, and the researchers hope their work will lead to more effective treatments for many of the most pressing diseases in humans.

The research team also includes Jeffrey Essner, professor of genetics, development and cell biology, and Iddo Friedberg, associate professor of veterinary microbiology and preventive medicine.

The technology that weve developed allows us to modify genes in a precise way that places gene activity under spatial and temporal control, McGrail said. One of the challenges in disease research is understanding the impact of gene loss at the cellular level. By modeling genetic disease in zebrafish, were able to reconstitute the complexity of human disease in a living system and visualize how cell processes are disrupted.

The method developed by McGrail and her colleagues combines gene editing technology with site-specific recombination enzymes. Utilizing the two in concert allows the scientists to control where and when a gene is deactivated. The new grant will also test approaches to optimize the efficiency of their method and expand on their ability to introduce more subtle gene changes frequently found in human disease genes.

Its like flipping a switch, McGrail said. We can deactivate a gene in a specific tissue, and investigate how that affects cell viability and organ function, providing insight into the process of disease pathology.

The research team also published an article in the peer-reviewed academic journal eLife, released this week, that lays the foundation for much of what they will do with the new grant. The paper describes the researchers ability to use gene editing to target integration into the genome, or introduce new DNA into the genome with great precision.

The zebrafish is a small, freshwater species, usually only a few centimeters in length, that makes an ideal model organism for genetic study because of the species transparent embryos, which allow for easy study. The zebrafish genome also shares up to 80% of the genes that cause disease in humans, Essner said.

Because of that high degree of conservation, we believe we can reach many human diseases, he said.

For instance, the researchers foresee a future in which gene editing technology could be used to treat certain kinds of cancer. McGrail said disease progression in some cancers is caused by gene deactivation, but what if doctors could reactivate those genes? Would that suppress the growth of tumors? McGrail and Essner said their research will take an important step toward answering such questions.

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Grant will help scientists break new ground in gene editing - Newswise

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Genomic Medicine Market 2020 | Know the Latest COVID19 Impact Analysis And Strategies of Key Players: Ingersoll Rand, Johnson Controls, Daikin, United...