Select Page ::

Can canine coronavirus drug indomethacin be used in treating humans suffering from COVID-19? – MEAWW

Posted on April 11, 2020 by Ashlie Lopez

A drug helped dogs fight off a type of coronavirus common in canines. Now, scientists believe the same drug might come to the rescue of humans suffering from COVID-19.

Though promising, the preprint study is preliminary. The study evaluated the drug Indomethacin against canine coronavirus. This virus, which is known to cause a highly contagious intestinal disease in dogs, shares ancestry with the new coronavirus.

Doctors prescribe indomethacin to reduce fever, pain, stiffness and swelling from inflammation. "Definitely worth additional testing of Indomethacin (Indocin), an anti-inflammatory from the 1960s, shown to inhibit CoV-2 & #coronavirus in dogs," tweeted Dr David Sinclair, from Harvard Medical School.

The focus is on old drugs because new treatments could take years to develop. "Given the urgency of the SARS CoV-2 outbreak, we focus here on the potential to repurpose existing drugs approved for treating infections caused by RNA viruses," the authors wrote in their study.

In one study, scientists showed that indomethacin can keep the SARS coronavirus a close relative of the new coronavirus from replicating inside cells. Scientists will learn more about its efficacy against the new coronavirus and its side-effects as they conduct more studies.

In this study, which has not been peer-reviewed yet, the team divided dogs infected with the canine coronavirus into three groups. Of the nine dogs that received an antiviral drug called ribavirin, three died. The second group fared a lot better. They received antibodies against the virus (anti-canine coronavirus serum) and only one dog died.

None of the dogs belonging to the third group died. Receiving Indomethacin, all the nine dogs survived the disease. What's more, dogs belonging to groups 2 and 3 recovered quickly.

"The results show, indomethacin can achieve a similar efficacy as treatment with anti-canine coronavirus serum, and superior efficacy than the treatment with ribavirin," the authors said.

As for lab-grown cells infected with the new coronavirus, they saw that indomethacin is toxic against the virus. Aspirin, on the other hand, was ineffective.

Drugs such as indomethacin and aspirin belong to a category of drugs called nonsteroidal anti-inflammatory drugs (NSAID). Doctors use them to treat pneumonia, which is common among severe COVID-19 patients.

However, some experts have raised an alarm against the class of drugs, suggesting that the drug might worsen the disease. "However, current scientific evidence does not indicate that patients with mildly symptomatic COVID-19 could be harmed by using NSAIDs," wrote Petros Ioannou, a post-doctoral researcher at the University Hospital of Heraklion, Crete, Greece, in the BMJ.

Earlier, France's health minister issued a warning against other NSAID drugs such as ibuprofen and cortisone. Other experts have said there is not enough evidence against the use of ibuprofen. The US Food and Drug Administration (FDA) issued a statement saying: "At this time, FDA is not aware of scientific evidence connecting the use of NSAIDs, like ibuprofen, with worsening COVID-19 symptoms. The agency is investigating this issue further and will communicate publicly when more information is available."

Is There Any Legitimate Health Advice in Gwyneth Paltrow’s "Goop Lab"? – InsideHook

Posted on April 11, 2020 by Ashlie Lopez

Welcome toThe Workout From Home Diaries. Throughout our national self-isolation period, well be sharing single-exercise deep dives, offbeat belly-busters and general get-off-the-couch inspiration that doesnt require a visit to your (now-shuttered) local gym.

The word energy already had too many meanings.

Border Collie puppies barnstorming around a backyard are energetic. Cereal bars that contain fructose and maltodextrin give us the energy we need to get through an afternoon. Whirring wind turbines convert kinetic mechanical energy to electricity. Bitcoin mining uses as much energy (in terawatt-hours) year-over-year as the entire Czech Republic.

The word officially entered into overuse, though, on episodes five and six of The Goop Lab. The fifth episode, literally called The Energy Experience, features LA-based body worker and somatic energy practitioner John Amaral, who has patients lie down on massage beds as he plays with an undiscovered dimension in the air four to six feet away from their bodies. In the sixth episode, a medium named Laura Lynne Jackson beams energy into sitters, then interprets concepts the universe sends back to her to communicate with the dead.

There is little point in getting too worked up over the confounding definition of energy that Gwyneth Paltrow, her lifestyle empire, and this TV show a six-episode docuseries that dropped on Netflix about 10 weeks ago have entered into the words canon. During Goop Lab, discussions on energy feel somewhat reminiscent of a sophomore philosophy class where no one has actually done the reading. It is a cosmic entity, not necessarily meant to be understood, but apparently deserving of a wry smile, a bemused tilt of the head, a pat on the back for trying. This is the gray area though goop often colors it Easter pink where pseudoscience thrives, where phrases like food for thought and give it a go legitimize (if not blatantly prioritize) anecdotal accounts over blind clinical trials. Its why the internet was ready the second this series dropped in late January, its why the United Kingdoms National Health Service outright declared the show a considerable health risk to the public.

Of course, the NHS has had to battle far more considerable health risks than Paltrowism in recent weeks. And its alarmingly tempting, in the age of COVID-19, as we all turn into streaming service ultra-marathoners, to even seek out what is widely-agreed upon nonsense. Anything thats intertwined with personal health, too, at a time when were all thinking of our bodies how to boost our immune systems, how to sweat without doing the same run for the 13th time since shelter-in-place began is extra alluring.

With all of that out of the way, I have a confession. I quarantine-binged The Goop Lab in its entirety this weekend. I went in with an open mind, refusing to read a single scalding review beforehand (those came later and seriously, these writers had their takes ready, they might as well have been dropping obits) and actively searched for legitimate, usable strategies, practices or concepts I could apply to my personal fitness. Why take goop so seriously? It has a $250 million valuation, millions of followers across all relevant social platforms, hugely successful pop-up shops in cities across the States, and yearly wellness summits attended by high-profile actors, athletes and authors. It matters, whether you like it or not. And besides, I enjoy learning new ways to feel and perform better. An open, patient ear helps in that regard.

That ear had to hear the word energy exactly 4,000 times over the season, but there actually was, believe it or not, some relevant wellness knowledge hidden within all the Goopian muck. That muck generally followed the same format: Paltrow and her Chief Content Officer Elise Loehnen interview a couple special guests in a perfectly-lit office where people whod rather be drinking sangria pitchers under delicately hung Edison bulbs drink hemp tea while riding around on bubblegum pennyboards. The special guests, whove taken select goop staffers on some sort of retreat in the weeks or months preceding, get a chance to explain their research and dish on one staffer who had a particularly strong reaction to the experience. There are only three episodes worth watching within that framework, and just two special guests especially worth remembering. These episodes are the second, third and fourth: Cold Comfort The Pleasure Is Ours and The Health Span Plan.

This episode focuses on aging, and introduces the work of both Dr. Valter Longo, a cell biologist who works at the University of Southern California, and Dr. Morgan Levine, a professor in pathology at the Yale School of Medicine. Both are concerned with the concept of aging as disease; similar to the work of Harvard geneticist Dr. David Sinclair, who I had the chance to speak to just last month, Dr. Longo has shown that aging can be addressed at the molecular level with various lifestyle changes. For example, hes a big believer in calorie restriction (intermittent fasting) and a pescatarian diet.

Dr. Levine, meanwhile, employs blood work to test for inflammation, metabolism, kidney and liver function, and cardiovascular health to determine a persons chronological age. Think of it as a true or internal age. When contrasted with your chronological age, a biological age is a more accurate arbiter for your risk of cancer, heart disease, or diabetes. Personal fitness, much like personal savings, thrives best on information. Sometimes, you have to look at your account balance to plan a way forward. Talk to your doctor about the best way to get your blood tested, or consider a biological age test. There are a few out there, including myDNAge, TeloYears, and InnerAge. If the number is above your chronological age, dont panic. Thats where the work of Dr. Sinclair is so helpful; hes proven in Cambridge that fasting, exposure to cold temperatures and high-intensity interval training will literally put years on your life and high-quality years, at that.

Easily Goop Labs most celebrated episode, and for good reason. The star is Betty Dodson, a 90-year-old whos been teaching women how to orgasm since the 70s. Shes a gynecologist with Bourdain vibes, a patchy jacket and no hesitation in correcting Paltrows odd misunderstanding of female anatomy. (What GP considers the vagina at one point during the episode is actually the vulva.) If youre a woman, this is essential, long-overdue TV Goop Lab does well to show over a dozen different types of vulva, after a discussion on the disconcerting rise of labiaplasty surgery, which has long been a mainstay in the porn industry. Most courageously, though, the episode closes with the orgasm of Dodsons fellow sex educator Carlin Ross, whom she guides through the experience. How does any of this relate to wellness?

For women, improved sexual awareness and a reliable masturbation routine can help improve mood, aid in sleep, improve confidence and communication with partners, and even reduce pain from menstrual cramps. For men who have female partners, those are all good things. When supported, youll likely grow closer with your partner, and have a healthier relationship which, we all know by now, has massive affects on personal wellness. For those who dont (but hope/plan to, one day), its an important kick in the pants, a lesson that the orgasms performed through porn are just that, performances, and expectations need to be personalized and constantly reset or reconsidered depending on the women theyre seeing.

Ill admit, I was a little surprised to see Wim Hof himself on an episode of Goop Lab. He doesnt just look like Santa Claus hes borrowed a bit of his aura, a rare 21st-century legend. Upon hugging him, Paltrow even laughed Youre actually real! The Dutch extreme athlete made it over 7,000 feet up Mt. Everest wearing only a bathing suit and shoes. Hes run half-marathons completely barefoot, on the ice and snow. He once made full-body contact with ice for nearly two hours. Hes an absolute maniac, in other words, just sans David Blaine intensity. Hes far more mischievous, and able to tap into that secret sauce when needed, like the original, puppet-Yoda of Empire Strikes Back. On Goop Lab he has eight staffers practice the three pillars of the Wim Hof Method: cold therapy, breathing and meditation. They breathe into their bodies, aggressively, filling the rib cage with air, until their limbs start tingling and their minds go numb (Ive practiced this before, with a surf yogi in Hawaii; its nuts), allowing their thoughts to drift away. Then they practice 20 minutes of snow-ga barefoot flows in the snow along the banks of Lake Tahoe before actually jumping into the water.

It would all be so perfectly goop if only Wim Hof, and cold therapy werent actually scientifically corroborated. Exposure to cold water is dynamite for mental health, which is the main benefit Wim Hof touts in the episode; it encourages the release of neurotransmitters like dopamine, adrenaline, norepinephrine and serotonin, all of which have anti-depressive effects. But it isnt too shabby for the body in general, either; occasionally swimming around in a freezing cold lake, or committing to a bonkers-chilly shower has been shown to catalyze post-workout recovery, stave off injury, lower blood pressure, increase metabolic rate and stimulate the immune system.

Netflix captured one hell of a moment Wim Hof yelling into the California winter as editorial assistants jumped into 38F water and like all TV, I guess, thats what this show was ultimately about, good shots and better soundbites. The disclaimer at the beginning of each episode did indeed portend that Goop Lab wasnt meant to replace medical advice. But at least that scene meant something. It gave something to the world, a proven practice that might be worth introducing to our daily doldrums. And at the very least, it gave that tiny, mighty word, energy, a well-deserved break.

Subscribe herefor our free daily newsletter.

See the original post here:
Is There Any Legitimate Health Advice in Gwyneth Paltrow's "Goop Lab"? - InsideHook

Will Universities, Colleges, And Law School Campuses Be Open In Fall 2020? – Above the Law

Posted on April 11, 2020 by Ashlie Lopez

Maybe? Maybe not?

The short answer is that there is no definitive answer yet. Universities and law schools arent ready to make a decision because the pandemic is so fluid and there is so much uncertainty, nor do they have to yet. But the question is being discussed on a daily basis, and we have spent a good deal of time speaking with college presidents, provosts, and deans and trying our best to get the most recent and trust-worthy epidemiological modeling and medical community input.

This podcast condenses those two perspectives that of higher education and that of the medical community into a prediction for the fall. Our prediction, based on speculation, and which we are going to devote continuous attention to over the next several months, is that it is likely many colleges and universities will not have on-campus classes this fall. This is particularly true for those schools that are able to take a semester or even year-long financial hit. We allude to Bill Gatess work that states this may be the once-in-100-years pathogen we have not been prepared for, and the infection rate of the virus plays into this prediction. Certainly there is a broad continuum where you could see some colleges entirely online, some with a hybrid online/on-campus model, and potentially some that are fully open.

What about law schools, the area our firm has the most expertise in? The dynamics are a little bit different here because law schools generally dont have, or dont have to have, student housing. Their student bodies are considerably smaller (there are roughly 112,000 total law school students in the country vs. 22 million college students), and thus with testing improvements and availability you could see law schools having a model where all faculty and students are tested, and those who test negative can be in the classroom, which would also be webcasted or recorded for those who cant be in the classroom for a variety of reasons.

In fact, we think some law schools will open and some will remain closed. They may start up, even independent of central university openings, or they may ride out a semester of online-only courses. Some may do the model described above and some may open fully with a hand on the button to shutter immediately if the spike comes back from the virus.

Pictured below the podcast is the model from Dr. David Sinclair Ph.D. we have been looking at, along with much of his other work, in formulating some of these speculations As the summer progresses this will become less speculative, and we will provide updates at any juncture we learn new information.

Listen to the full podcast here:

(Graph via Dr. David Sinclair Ph.D.)

MikeSpiveyis the founder of TheSpiveyConsulting Groupand has been featured as an expert onlaw schoolsand law school admissions in many national media outlets, includingThe New York Times,The Economist,theABA Journal,The Chronicle of Higher Education,U.S. News & World Report,CNN/Fortune,andLaw. Prior to foundingSpiveyConsulting, Mike was a senior level administrator atVanderbilt,Washington University, andColoradolaw schools. You can follow him onTwitterandInstagram or connect with him LinkedIn.

Read the original here:
Will Universities, Colleges, And Law School Campuses Be Open In Fall 2020? - Above the Law

Is soaking in a frozen lake the secret to good health? – The Detroit News

Posted on February 12, 2020 by Ashlie Lopez

Richard Chin, Star Tribune (minneapolis) Published 5:55 p.m. ET Feb. 11, 2020

Ponce de Leons search for the fountain of youth in Florida is just a legend.

But about 1,500 miles to the north, in the icy waters of Cedar Lake in Minneapolis, dozens of people think theyve found the next best thing.

On a recent Sunday around 9:30 a.m., a diverse group of about 20 people dressed in swimsuits trekked to a spot near the shore on the west side of the lake and immersed themselves in an 8-by-12-foot rectangular hole cut in the ice. Later in the day, another group of people gathered to do the same thing.

This isnt a once-a-year, get-in, get-out, New Years Day plunge for Instagram bragging rights.

Throughout the winter, biohackers maintain a hole in the ice chopped into Cedar Lake in Minneapolis in the belief that regular cold water immersions make them healthier.(Photo: Richard Tsong-Taatarii / TNS)

This is something that happens every Sunday throughout the winter.

Some people come several times a week, and stay for a good, long soak of five, 10, 15 minutes or more. Except for the knit hats, they look like they could be relaxing in a hot tub as they stand in water that ranges from waist- to neck-deep.

Called cold therapy or cold thermogenesis, ice-water bathing is a practice that biohackers and assorted others believe makes them healthier.

The Twin Cities Cold Thermogenesis Facebook group, which was created in 2016, claims the frigid dips do everything from increase testosterone in men to boosting brown adipose tissue. (The so-called brown fat or good fat may be helpful in combating obesity because it burns calories to create heat.)

Cold-water immersion also strengthens the immune system, according to Svetlana Vold, a part-time firefighter and ultramarathon winter bike racer from St. Louis Park, who organizes the Sunday morning cold-immersion session.

Vold and others say chilling out in the water combats inflammation, helps them sleep better and improves their focus and endurance. Some said theyre inspired by Wim The Iceman Hof, a Dutchman famous for his breathing and cold exposure technique called the Wim Hof Method.

The Cedar Lake group would probably meet the approval of David Sinclair, a Harvard genetics professor and longevity expert who thinks that cold exposure may help slow the aging process.

Maria OConnell, the organizer of the afternoon session, has been immersing herself in an ice-filled horse trough in her backyard since 2011. Initially its a little uncomfortable, she said. You end up getting better the more you do it.

But many say the frigid dunks are a mood-altering, even pleasurable experience.

It hurts so damn good, said Stephen McLaughlin, a 61-year-old Minneapolis resident. You are just completely present.

It makes me happy. I think its adrenaline, said Allison Kuznia, 42, of Minneapolis.

Its kind of a treat to go out and get really cold, said Nick White, 46, of Minneapolis. It gives you a feeling of euphoria.

Read or Share this story: https://www.detroitnews.com/story/life/wellness/2020/02/11/soaking-frozen-lake-secret-good-health/41217451/

Link:
Is soaking in a frozen lake the secret to good health? - The Detroit News

Flipping the switch on the ageing process – The Age

Posted on March 21, 2020 by Ashlie Lopez

Sinclair was scheduled to discuss his ideas with Norman Swan, host of Radio Nationals Health Report, at Ageing is a Disease at Sydney Town Hall on April 4 as part of the Festival of Dangerous Ideas, which was cancelled last week.

David Sinclair says ageing fulfils every criteria for what medical textbooks define as a disease.Credit:Nic Walker

Sinclair says the coronavirus pandemic, which is causing a higher fatality rate among the elderly, gives urgency to his research into the ageing process. "Our research is aimed at delaying or reversing age-related diseases and providing the elderly with resilience," he says. "Other labs have shown in human clinical trials that immune responses in the elderly can be boosted by molecules that target ageing, such as low dose rapamycin."

But Sinclairs argument that ageing is a disease may cause some unease. He says ageing causes frailty, sickness and eventually death, fulfilling every criteria for what medical textbooks define as a disease. The only difference is that ageing happens to everyone, whereas cancer and heart disease do not. Were very good at preventing heart disease but we havent been successful at delaying ageing of the brain, he says. So weve ended up with the worst nightmare - were increasing lifespan but not healthspan as much.

"Its also not recognised that age is what causes those diseases in the first place," he adds.

Describing ageing as a disease also sounds to some ears like it is stigmatising older people. I find that people over 50 tend to get upset when you call ageing a disease, he says. But people under 50, particularly people in their 20s and 30s, they totally embrace this idea. They don't want to get sick. They think technology can solve everything.

Sinclairs book Lifespan, subtitled Why We Age, and Why We Don't Have To, outlines his 25 years of research into ageing, which he likens to corrupted software.

Getting older amounts to a loss of what he calls epigenetic information. Essentially its the information that tells the cells how to read the genes in the right way and stay young, he says. In the same way that a genome is the computer, the epigenome is the software. And so I'm proposing that ageing is corrupted software.

Sinclair says his research has also revealed there is a back-up copy of our software. If its corrupted, weve figured out a way to reboot the cell and be young again.

In Lifespan, he describes experiments in which old mice have been given gene therapy that restores their eyesight to that of young mice. The idea is we still have all the information to be young again in our bodies if we can just flip the switch, he says.

Sinclairs effort to reboot cells is undergoing pre-clinical trials to test the safety and efficacy of the procedure. Within the next three years, he aims to treat patients who have lost their vision as a result of glaucoma - a disease that can be controlled but cannot be cured.

Do I know if its going to work in people? he says. Of course not. Nobody knows until you do the clinical trials.

Sinclairs research into ageing is slowly gaining acceptance among scientists and medical professionals. British scientists Robert Faragher and Stuart Calimport said last year on academic website The Conversation that the World Health Organisations International Classification of Disease should be amended to classify ageing as a disease.

However, Sinclair says it is hard to change regulations and the habits of doctors who have been taught that ageing is inevitable and not something we can treat.

It takes radical thinking to overcome what youve taken for granted your whole life, he says.

Sinclair traces his interest in ageing to childhood and a conversation with his grandmother Vera. I remember very clearly that my grandmother told me everything is going to die, he says. The cat was going to die, she was going to die and my parents and I would.

Sinclair describes his grandmother as a huge rebel who taught him to question dogma and authority. He recalls with pride how she was ejected from Bondi Beach in 1957 for wearing a bikini one year after she fled Hungary following the Soviet invasion. She taught me that humans can do evil and can do amazing good, he says. And she said: David that's what you should do with your life is leave the world better than you found it.

Sinclair says his aim is not to cheat death, but to allow older people to stay healthier for longer. There are plenty of people who look at what its like to be 100 and say Heaven forbid, I don't want to get old, he says. But thats missing the point, which is you could be 80 or 90 and still play tennis and hang out with your grandkids and be productive like my father is at 80.

Sinclair says preventing illness is the key to improving quality of life and reducing the burden on family and society. Its what we see in our animal studies, he says. They live longer because theyre healthy. Thats the only way I know to keep something living longer is to prevent them getting sick.

However, Sinclair cautions that his research will not deliver the magic bullet that allows people to eat, drink and be merry without consequence. If you live a healthy lifestyle and eat all the right foods are you going to live beyond 120? Probably not, he says. On the other hand, the average lifespan for humans used to be about 40 years. And weve used technology to improve our health - thats what we do as human beings."

Andrew Taylor is a Senior Reporter for The Sydney Morning Herald.

Read more from the original source:
Flipping the switch on the ageing process - The Age

Remembering loved ones who have passed away – the 68 death notices in North Staffordshire this week – Stoke-on-Trent Live

Posted on March 31, 2020 by Ashlie Lopez

This week, these are the loved ones remembered in the funeral notices and family announcements in The Sentinel.

To see the full list of family announcements, visit this section of the StokeonTrentLive website where you can search by name, date and location. You can also post your own announcements and notices there.

You can also see the latest listings from your area on the InYourArea section.

Here are is a list of those to appear in North Staffordshire in the last week.

CAINE Lily

Passed away peacefully on March 16th 2020, at the R.S.U.H. Lily, aged 95 years of Dresden, (formerly of Bentilee). The dearly beloved wife of the late Joe, loving mum of Alma, dearest mother-in-law of the late Neil, much loved nan and great-nan of James and Eva.

Dearest sister of Jean and a very dear aunty. Lily will be sadly missed by all who knew her. A private service will be held at Carmountside Cemetery on Tuesday April 7th at 11:00am.

Floral tributes welcome, or if preferred donations for St. Mary's Church, Bucknall. Donations and enquiries to: Williamson Brothers Family Funeral Directors, Birch House, Birches Head Road, Hanley, ST1 6LH. Tel. 01782 212880.

GRIFFITHS Leslie John Les

After a short illness at the R,S,U,H on Thursday 19th March 2020. Les aged 88 years of Blurton. Much loved Husband to the late Edith, Treasured Dad to David, Neil and Linda, Also Father in law to Kelvin and Elaine and a dear companion to Joyce.

Les will be sadly missed by all his loving Family and Friends. A Private Funeral Service to be held at Carmountside Crematorium on Friday 3rd April 2020 at 10.00am,

Will all relatives please accept this only intimation. Flowers welcome or donations if preferred and made payable to Prostate Cancer UK. Mourners please disburse at the crematorium.

Due to Government restrictions and Social Distancing only 10 mourners will be allowed into the crematorium, This includes immediate Family members, Invitation only. Care of the Funeral Director.

All Enquiries to: Neil Venables Dolven Funeral Services Independent Family Funeral Directors 1 Nashe Drive, Blurton Stoke on Trent ST3 2HD 01782 599156

GROCOTT Terence (Terry)

At rest on 17th March 2020 at the RSUH, Terry aged 92 years of Shelton.

The dearly loved and devoted husband of Pauline, much loved dad of Lynda, Philip and Richard, loved father-in-law of Mandy and Susan, treasured grandad and great-grandad.

A private funeral service and cremation will take place at Carmountside Crematorium on Monday, 6th April at 2.30pm.

No flowers by request, donations preferred for the North Staffs Heart Committee. Donations and enquiries to Williamson Brothers Family Funeral Directors, Birch House, Birches Head Road, Hanley, ST1 6LH. Tel. 01782 212880.

HAYNES Wendy

Peacefully on 21st March 2020 at Haywood Hospital, Wendy aged 61 years, of Eaton Park.

The dearly loved wife of Alan, much loved mum of Sadie and Jennie, loved mother-in-law of Paul, treasured nannie of Emily, Liam and Addison, loving sister to Lesley and a loved sister-in-law, aunt and friend. Funeral arrangements later.

Enquiries to Williamson Brothers Family Funeral Directors, Birch House, Birches Head Road, Hanley, ST1 6LH. Tel. 01782 212880.

HOWLE Sheila

Suddenly on 5th March 2020 at her home in Berryhill, Sheila aged 69 years. The dearly beloved wife of the late Bill, much loved mum of Chris, Julie, Debbie and the late Sharon, loved mother-in-law, treasured nan and great-nan, a loving sister, sister-in-law, aunt and friend.

A private service and cremation will take place at Carmountside Crematorium on Thursday, 2nd April at 3.00pm.

Flowers or if preferred donations for Pink Sisters Staffs. Donations and enquiries to Williamson Brothers Family Funeral Directors, Birch House, Birches Head Road, Hanley, ST1 6LH. Tel. 01782 212880.

JERVIS Jill Mary

Peacefully at rest surrounded by her loving family on Tuesday 17th March 2020 at Beech Lodge Nursing Home Cheadle. Jill aged 81 years of Cheadle.

Loving and devoted Wife of John, cherished Mum of Tim and Justine and a dear Mother-in-law of Debby. Jill will be sadly missed but fondly remembered by all her loving family and friends. It is with sadness that a service cannot take place at Jill's place of worship due to the current government regulations, but instead a private service will be held at Carmountside Crematorium.

Will all relatives please accept this intimation, friends wishing to attend kindly meet at the above crematorium. Family floral tributes only please, donations if desired for the care of The Stroke Association.

Donations and enquiries to J.P Keates and Son Funeral Directors, Bank House, 37 Bank Street, Cheadle, ST10 1NR. Tel. 01538 752164 http://www.jpkeatesandson.co.uk

LAWTON Rita

At rest on 17th March 2020, at the RSUH. Rita aged 76 years, of Smallthorne. The dearly beloved wife of the late Graham, much loved and devoted mum of Steven, loving mother-in-law of Donna, loved and respected by Shirley and David.

Rita is fondly remembered and will be sadly missed by all who knew her. A private service and cremation will take place at Carmountside Crematorium on Tuesday April 7th at 12 noon.

Family flowers only please. Donations preferred for St Saviour's Church or Woolridge Court Comfort Fund. Donations and enquiries to: Williamson Brothers Family Funeral Directors, Birch House, Birches Head Road, Hanley, ST1 6LH. Tel. 01782 212880.

LEE Sharon

Suddenly on 12th March 2020 at her home in Bentilee, Sharon aged 41 years.

The dearly loved partner of Leon, much loved mum of Matthew, Meg, Joshua, Bethany and Billy, loved daughter of the late Sheila and Bill, a loving sister, sister-in-law, aunt and friend. A private service and Cremation will take place at Carmountside Crematorium on Monday 6th April at 10.30am.

No flowers by request. Donations preferred for the UHNM Charity Neonatal Unit. Donations and enquiries to Williamson Brothers Family Funeral Directors, Birch House, Birches Head Road, Hanley, ST1 6LH. Tel. 01782 212880.

MOUNTFORD Derek (Knocker)

At rest on 22nd March 2020 at Lawton Rise Nursing Home, Goldenhill, Derek, aged 80 years of Middle Port. The dearly loved and devoted husband of Audrey, much loved dad of the late Sharon and Nicola, loved father-in-law, treasured grandad and great-grandad, a dear brother, brother-in-law and uncle.

A private service and cremation will take place at Bradwell Crematorium on Wednesday April 8th at 2pm. No flowers by request, donations preferred for Alzheimer's Society.

Donations and enquiries to Williamson Brothers Family Funeral Directors, Birch House, Birches Head Road, Hanley, ST1 6LH. Tel. 01782 212880.

SPRUCE Derek

PRIVATE SERVICE ONLY

Peacefully at rest on 16th March 2020 at Springbank Nursing Home, Knypersley, Derek aged 89 years.

Dearly loved and devoted Husband of Margaret, beloved Father of Helen & David, Dear Father in Law of Eid & Melanie, Treasured Grandy of Andrew, Abbie, Nathan, Amy, Omar & Tarik, Much loved Brother in Law, Uncle & Friend to many.

Donations if desired to either Approach or Dementia UK. Enquiries to: John Garside & Son, 2 Cross Street, Biddulph, Stoke on Trent ST8 6BD Telephone: 01782 513210.

WILLIAMS Ivy (nee Marshall)

At rest on March 23rd 2020 at the RSUH, Ivy aged 89 years of Bucknall. Much loved wife of the late Bob Marshall and the late Ted Williams, devoted mum of Linda, Stephen, Gary and Robert, dear mother-in-law and a cherished nan and great-nan.

Ivy will be fondly remembered by all her family and friends. A private graveside service will be held for Ivy's immediate family only at St Mary's Church, Bucknall.

Family flowers only please, donations if desired for Cancer Research UK. Donations and enquiries to Williamson Brothers Family Funeral Directors, Birch House, Birches Head Road, Hanley, ST1 6LH. Tel. 01782 212880.

WOOLRIDGE Graham

Peacefully at rest on Monday 16th March at The RSUH, Graham aged 77 years of Dresden, devoted husband of Margaret, much loved dad of Neil and a dear father in law of Jacqui, treasured grandad of Ross and Todd and their partners Lucy and Amy, great-grandad of Mai-Rose the apple of his eye, and dear brother of Jean. Graham will be sadly missed by all his family and friends.

Family flowers only please. Private family funeral service and cremation to be held at Carmountside Crematorium.

Share your condolences online at funeral-notices.co.uk where you can also donate to The British Heart Foundation in the memory of Graham. Enquiries to:- W.R. BETTELLEY Funeral Directors, 315 Uttoxeter Road, Longton, Stoke on Trent, Tel. 01782 313542

BAILEY David

Suddenly at home on 13th March 2020, David Sinclair aged 60 years of Whitmore.

The dearly loved husband of Catherine, loving dad of Georgina and Louisa and a dear brother of Adrian and Phillip. Due to the crisis we are all experiencing, a private family funeral will take place, but a Service to Celebrate David's life with all family and friends will be announced in due course.

Donations in David's memory may be made to the Douglas Macmillan Hospice and the R.N.L.I. All donations and inquiries to JOSEPH EDWARDS & SONS, Independent Funeral Directors of Alsager and Kidsgrove. Tel: 01270 882097 or 01782 775333.

BOON John Aubrey

PRIVATE SERVICE ONLY. At rest at the Royal Stoke University Hospital on 18th March 2020, John, aged 86 years of Biddulph. Devoted husband of the late Ellen Boon, dearly loved Dad of Angela, Colin, Gary, & Gay, loved Father in law of David, Jill, Sue & John, Cherished Grandad of Michelle, Lee, Mark, Natalie, Sophie & Georgi, Great Grandad of Jaymie-Leigh, Jake & Lillie also a very dear Brother & Brother in law.

John will be sadly missed by his family & friends. A Private Service will take place on Monday 6th April 2020. Donations please in lieu of flowers to St Lawrence Church.

Enquiries to: John Garside & Son, 2 Cross Street, Biddulph, 01782 513210.

BRADBURY John Cyril

Passed away peacefully surrounded by his loving family on 19th March 2020. The dearly loved and devoted husband of Gwen and much loved Dad, Grandad and Brother.

Will be fondly remembered and sadly missed. Due to the Covid 19 outbreak a private cremation service will take place.

A celebration of John's life will be arranged at a later date where all John's family and friends can safely attend. Donations to Royal Stoke University Hospital.

All inquiries to: Harold H Leese (A.Boulton & Sons) Funeral Directors & Memorial Masons St Peter's Close Stoke on Trent Staffordshire ST4 1LP

CARP Mike

Suddenly on 7th March 2020 at the R.S.U.H. Michael John (Mike) aged 69 years of Brown Edge and formerly of Stockton Brook, devoted husband of Susan, much loved dad of David, father-in-law of Clare, loving grandad of James, brother to Russell and Jean and a dear brother-in-law, uncle, nephew and friend to many.

Funeral private, family flowers only please, donations to Multiple Sclerosis. Inquiries to S. Sigley & Sons, Leek Tel 01538 382048

COLCLOUGH Nora

Peacefully at rest on Sunday 15th March 2020 at the R.S.U.H. Nora aged 91 years of Tean. Dearly beloved wife of the late Christopher George. Much loved and loving mum of Robert.

Devoted grandma of Helen and Emily and great grandma of Callum. Also dear sister of Ron Tranter. Nora will be sadly missed by all her loving family and friends.

The Funeral Cortege will leave Harry Dawson Funeral Services on Tuesday March 31st at 11.30am for service and cremation at Carmountside Crematorium at 12.00 noon.

Due to unprecedented circumstances surrounding COVID - 19 ( Coronavirus Pandemic ) Nora's funeral will remain private for all except close family members.

No flowers please by request donations preferred for The Douglas Macmillan Hospice Blurton c/o The Funeral Director.

Donations & Enquiries to NICOLA DAVIES HARRY DAWSON FUNERAL SERVICES 105 Upper Normacot Road Normacot, Longton. Tel : 313428.

COTTON ALAN

Bernard Suddenly, after a long illness, at RSUH on Monday, 16th March, 2020, surrounded by his loving family, Alan aged 89 years of Longton.

Beloved husband of the late June, much loved dad to Jane and Lynn and father-in-law to Darren, a treasured grandad, great-grandad and a dear brother Private family funeral service and cremation to be held at Carmountside Crematorium Family flowers only please.

Share your condolences online at funeral-notices.co.uk where you can also donate to British Heart Foundation in memory of Alan Enquiries to:- W.R. BETTELLEY Funeral Directors, 315 Uttoxeter Road, Longton, Stoke on Trent, Tel. 01782 313542

GOLLINS Esther Ann

Peacefully at rest on Monday 16th March 2020 at her home, aged 86 years of Madeley. Beloved wife of Peter, dearly loved mum to Amanda, Christine and the late Christopher.

Esther will be sadly missed, but fondly remembered by all her loving family and friends. Funeral service and cremation to be held at Bradwell Crematorium on Friday 3rd April 2020 at 9.20am.

Would relatives and friends kindly meet at the crematorium. Family flowers only, donations if so desired to Marie Curie Nurses. All inquiries to: MARSH & SON Funeralcare 36 Friarswood Road, Newcastle Tel. 01782 717019.

HANCOCK Lionel Robert (Coal Merchant)

At rest on 17th March 2020 at the Royal Stoke University Hospital, Lionel aged 80 years of Bradwell. Devoted husband of the late Jean, treasured dad of Sean and Diane, father in law of Annette and John, much loved grandad of Nathan, Maxine, Brett and Ellie, great grandad of Nelly and a beloved partner and soulmate of Rita. Lionel will be sadly missed but fondly remembered by everyone who knew him.

Funeral Service to be held at Bradwell Crematorium on Tuesday 31st March 2020 at 12.40pm.

Family flowers only please donations would be much appreciated to Douglas Macmillan Hospice and Pancreatic Cancer UK. Hopkinson Wootton Lovatt Hopkinson House, 15 Chetwynd Street, Wolstanton, ST5 0EQ. Telephone: 01782 715152. http://www.hopkinsonwoottonlovatt.co.uk

HARRISON Peter

Passed away peacefully on 5th March 2020 at Glan Clwyd Hospital, Bodelwyddan, Peter aged 60 years. The dearly loved and devoted Husband of Anne. Brother of Anne, Brother in law of Roger and Julie. Uncle of Simon, Michelle. Great Uncle of Lauren, Ashton, Logan, Jaxon, Lucas. Great Great Uncle of Shelby and Eliana. Service and Cremation to take place at Bradwell Crematorium on Thursday 2nd April 2020 at 1.20pm.

Will relatives please accept this the only intimation and friends wishing to attend kindly meet at the Crematorium. Family flowers only donations if desired to BCU HB Glan Clwyd Hospital ITU Department.

All enquiries and donations to Alan Finneron Funeral Directors, 32 West Street, Congleton CW12 1JR Tel 01260 277622. http://www.afinneron.co.uk

JOHNSON Harvey

Peacefully at home on Tuesday 17th March, 2020, much loved dad of Pat, Peter and Kath, grandad and great grandad.

Reunited with his loving wife, the late Kath. Resident of Abbey Hulton, the funeral service and burial will take place on Friday 3rd April at Carmountside Cemetery at 12.30pm.

Family flowers only by request, donations in lieu of flowers can be made to Cancer Research UK. Funeral enquiries to: Coop Funeralcare, Leek Rd, Abbey Hulton Tel: 01782 535184.

Original post:
Remembering loved ones who have passed away - the 68 death notices in North Staffordshire this week - Stoke-on-Trent Live

Movers and Shakers Week Ending 2.28.20 – milehighcre.com

Posted on February 28, 2020 by Ashlie Lopez

Rodney Anderson

Alliant National Announces Addition of Executive Vice President and National Agency Manager

Alliant National Title Insurance Company, a unique title insurance underwriter that partners with independent agents to improve their competitive position in the marketplace, announced that Rodney Anderson has been promoted to executive vice president and national agency manager, effective immediately.

Anderson will expand his current responsibilities for developing, marketing and managing Alliant Nationals Southwest Region Agency operations to include national market expansion and oversight of the companys 32 licensed state agency operations.

Anderson will be a member of the senior executive leadership team working to aggressively expand Alliant Nationals footprint.

I am honored that our CEO and ownership group, Presidio Partners, has placed their trust in me with such a key role within Alliant National, says Anderson. Throughout my career I have worked to support the independent agent, and I look very forward to working with the agency team assembled at Alliant National to help independent agents across the country.

Anderson is a seasoned real estate and title insurance industry expert with over thirty years experience in agency operations as the current Southwest regional manager for Alliant National, former co-owner of an independent title agency, and agency operations manager for a national independent agency. In addition, Mr. Anderson served three full terms as a State Representative in the Texas Legislature.

It is not often one gets the opportunity to work side-by-side with an industry professional of Rodneys caliber, says David Sinclair, Alliant National president and CEO. His unique experience combined with his passion for independent agents makes him the perfect person to lead our agency team, particularly at this juncture of accelerated company growth.

Alliant National distinguishes itself from competitors by combining strong underwriting capability with independent agents in-depth knowledge of local markets. The result is a nationwide network with deep roots in local communities, and a wealth of expertise that is flexible, nuanced and continuously growing.

Gensler Promotes 9 in Denver

Gensler, a global architecture, design, and planning firm, announced the promotion of nine in its Denver office.

Juan Padilla

Bekah Wagoner

Austin Zike

Juan Padilla,Rebekah Wagoner,AIA, LEED-AP, and Austin Zike, NCIDQ, IIDA, RIDwere promoted to associate.Juan Padilla is an architectural designer with experience across workplace to lifestyle project types.Rebekah Wagoner is an architect with 10+ years of experience with a passion for sustainable solutions for the built environment. Austin Zike is a senior project manager with 20+ years of experience successfully delivering large, complex projects across many sectors of workplace design.

Joy Hughes

Ronnie Leone

Erin Vinezeano

Joy Hughes, AIA, Ronnie Leone, IIDA, ErinVinezeano, AIA, and Michael Yeager, AIA were promoted to senior associate. Joy Hughes has been an architect with Gensler for 20 years and is a regional leader forthecritical facilities practice area.Ronnie Leone is an interior designer with 10+ years of experience designing award-winning creative workplaces for technology and financial services firms.She is also takingon a new role as Co-Studio Director. ErinVinezeano is an architect and interior designer with 10+ years of experience in a wide range of project types, from professional services to technology workplaces, including multiple nationally publicized workspaces.Michael Yeager is anarchitect with 20+ years of experience in a range of project types, recently leading three major development projects in Denver.

Michael Yeager

Christy Headlee

Alex Garrison

Christy Headlee, IIDA, LEED AP and Alex Garrison, AIA were promoted to design director. Gensler design directorsare thought leaders and stewardsfor design excellence; they are responsible for overall design quality of their projects and advancing the Gensler design culture. Christy Headlee is an interior designer with 10+ years of experience. She leads design efforts with intention and bold creativity. She is collaborative, passionate about inspiring and empowering others and is an inclusive leader who mentors and inspires others to explore their own creativity. Alex Garrison is an architect with 10+ years of experience. He is an award-winning designer who brings a strong conceptual approach to every design opportunity. A firm believer in always being curious, he leads project teams in the tireless pursuit of innovative design solutions.

Dunton Commercial Announces Two New Hires

Brett Welker

Caleb Krumsieg

Dunton Commercial, a Denver-based commercial property management and investment company has hired Brett Welker as the new director of property management and Caleb Krumsieg as the new director of Leasing.

Welker brings tremendous experience and leadership to our property management team, as well as asset management, acquisitions analysis and due diligence to our investment side of the business. He has achieved the designations of RPA (Real Property Administrator, BOMA) and CPM (Certified Property Manager, IREM).Prior to Dunton, Welker spent 21 years with Lowe, a commercial real estate investment company, most recently as vice president.

Krumsiegs focus at Dunton is to maintain high occupancy levels within the portfolio by leveraging Duntons technology and implementing a highly pro-active leasing strategy. He brings significant office and retail leasing experience to Dunton, most recently as a broker with Waveland Property Group in Wheaton, IL. Krumsieg has a B.A. in Business and Economics from Wheaton College.

Follow this link:
Movers and Shakers Week Ending 2.28.20 - milehighcre.com

Pilot Wins Top Honors at Awards Ceremony | Business – Southern Pines Pilot

Posted on March 3, 2020 by Ashlie Lopez

From left, Pilot staff photographer Ted Fitzgerald, reporter Laura Douglass, editor John Nagy, reporter Jaymie Baxley, and The Sway's Mackenzie Francisco, Melissa Kohlman, and Abbi Overfelt. Photo: David Woronoff/The Pilot

The Pilot took home the prestigious first place award in General Excellence in its division at the annual North Carolina Press Association News, Editorial and Photojournalism contest held Thursday.

The 2019 awards were presented Thursday as part of the NCPAs Winter Institute. More than 100 newspapers from across the state were represented and 4,400 entries were submitted..

In competition among non-daily community newspapers with circulation over 10,000, The Pilots staff members accounted for 16 news and editorial and 19 advertising awards presented at the Marriott Crabtree Valley in Raleigh.

The Pilot has previously earned the top award for General Excellence in 2017, and 2010. The Pilot placed third in that category in 2015 and last year.

Our core purpose has always been to serve our community. We believe that publishing a great newspaper is the best service we can render, said Pilot publisher David Wornoff. While were proud of this award as it recognizes the outstanding work of our dedicated staff, its the pride that our readers feel for the newspaper that brings infinitely more satisfaction.

In addition to print content, The Pilot swept the email newsletter category, taking first place for the twice-weekly Pilots Briefing, and second and third place honors for The Sway.

The top prize for best niche publication went to Pinestraw magazine, produced by The Pilot; and the special section Best of The Pines earned first place in the category, with A Guide to the Sandhills taking second place.

Publisher David Woronoff and editor John Nagy earned first place for editorial page, and Nagy took home third place in the individual category for editorials.

An emphasis on the transparency, and consequently the quality, of local government provides a service to readers of The Pilot, the judges said.

Among the other individual news awards to members of The Pilot staff, writer Deborah Salomon took first place in beat feature reporting and third place in feature writing.

Reporter Jayme Baxley took second place for sports enterprise writing.

Managing editor David Sinclair took third place in sports columns and third place in sports feature photography.

Staff photographer Ted Fitzgerald slid into second place in sports feature photography and third place in photo page or essay.

Fitzgerald, Sinclair and Brandi Swarms also earned third place in the feature photography category for their front page coverage of area high school graduation ceremonies last June.

The recognition of our peers is gratifying, but the feedback that means more to us is what we receive from people in the grocery store aisles and at church and around town, said editor John Nagy. The Pilots strength has always been and remains the connections its people have with their community.

In a separate ceremony Thursday afternoon, The Pilots advertising staff collected 19 awards for their work, including top honors for best overall performance for the third consecutive year.

Patty Thompson and Scott Yancey racked up an impressive number of first place awards in advertising categories, including healthcare and medical, best home furnishings and appliance ad, for a retail ad and, separately, a service ad in a niche publication.

From left, ad rep Samantha Cunningham, advertising director Ginny Trigg, and graphic design manager Mechelle Butler.

Yancey also earned first place with Dacia Burch for best apparel, jewelry and accessories ad.

The Pilots ad staff earned first place in the community services signature page for their Valentines Gift Guide, first place and second place in the niche publication category, and first place and third place for special section.

Wow. Just wow, the judges said. Every page is gorgeous photo, content, layout work together with flare, elegance and personality.

Thompson and Yancey also individually took second place for apparel, jewelry and accessories ad and healthcare medical ad.

Perry Loflin and Yancey took second place for retail ad in a niche publication.

A third place award was presented to Burch and Yancey, and Terry Hartsell and Mechelle Butler for home furnishings and appliance ad. Additional third place prizes were awarded to Thompson and Yancey for retail ad, and Butler and Samantha Cunningham for use of color in advertising.

Were so proud of the fantastic work that our advertising team produces all year long, said Ginny Trigg, The Pilots advertising director. It's especially rewarding to be recognized by our industry peers for the ads that were creating. We share the awards with our advertising partners for trusting us with their marketing.

The Pilots winning advertisement partners included CoolSweats, Monkees of the Pines, Burney Hardware, Wedgies, Bell Tree, Sweet Dreams Mattresses and More, Elmore Furniture, Pinehurst Medical Clinic, Karma Beauty Bar, Sothebys, The Ice Cream Parlor.

Originally posted here:
Pilot Wins Top Honors at Awards Ceremony | Business - Southern Pines Pilot

Letter: Yes to Green Growth | Opinion – Southern Pines Pilot

Posted on January 28, 2020 by Ashlie Lopez

Yes, yes and yes! to Pinehursts conversation about green growth as reported by David Sinclair in his recent front-page article.

All communities in Moore County should be engaged in discussions about what value and vitality mean for the long term. Lets continue considering how we fit into a larger set of processes, including our natural environment which provides us with priceless essentials like clean water and air.

Living alongside nature in deep partnership now will ensure better lives for the generations who follow us.

Greta Nintzel, Whispering Pines

Publishers Note: This is a letter to the editor, submitted by a reader, and reflects the opinion of the author. The Pilot welcomes letters from readers on its Opinion page, which serves as a public forum. The Pilot is not in the business of suppressing public opinion. We are a forum for community debate, and publish almost every letter we receive. For information on how to make a submission, visit this page:https://www.thepilot.com/site/forms/online_services/letter/

See the original post here:
Letter: Yes to Green Growth | Opinion - Southern Pines Pilot

Anti-Aging Researcher David Sinclair Takes Metformin, NMN …

Posted on February 22, 2020 by Ashlie Lopez

David Sinclair is working on various anti-aging molecules. He was famous for discovering the anti-aging effect of resveratrol and sirtuins. David Sinclair was interviewed on the Joe Rogan show about antiaging.

In 2013, GlaxoSmithKline shutdown Sirtris (David Sinclairs company) about five years after spending $720 million to buy Sirtris.

David A. Sinclair, Ph.D., A.O. is a Professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. Dr. Sinclair is co-founder of several biotechnology companies (Sirtris, Ovascience, Genocea, Cohbar, MetroBiotech, ArcBio, Liberty Biosecurity) and is on the boards of several others. He is also co-founder and co-chief editor of the journal Aging.

Life Biosciences was co-founded in 2017 by David A. Sinclair, PhD, AO, a professor in the Department of Genetics at Harvard Medical School, and Tristan Edwards, an investment professional who developed its innovative company structure.

Sinclairs lab continues to work on resveratrol and analogs of it, as well as on mitochondria and NAD, all directed to understanding aging and how to prevent it.

His antiaging regimen is to activate pathways to improve the bodies defenses against aging.

He is testing NMN on human subjects. He describes NMN is fuel for sirtuins. NMN is related to NR. NR increases the levels of NAD. Sirtuins need NAD to work. We lose NAD as we age. We have half of the NAD by the time we are 50.

He takes a gram of NMN (Nicotinamide MonoNucleotide) and takes half a gram resveratrol in the morning with yogurt.

He is personally taking 1 gram of Metformin once a day at night.

He gives himself temperature treatments. He exposes himself to heat in a hot tub and then cold in a cold bath. The temperature treatments are again to activate the pathways to aging defense.

He also performs intermittent fasting. He skips meals and is a night time eater. He limits is sugar and carbs. He limits his eating of meat.

He is not taking Rapamycin because of concern over side-effects.

Anti-oxidants are a failure in the anti-aging field.

Metro Biotech makes a super-NAD booster which is called MIB-626. They hope to get it on the market to treat diseases in three years. It is in clinical trials for safety now.

Research has found the lining of blood vessels needs NAD.

SRT-2104 has had successful antiaging effects.

He gave the recent keynotepresentation atMonteJadeevent with a talk entitled the Future for You.He gave an annual update on molecular nanotechnology at Singularity University on nanotechnology, gave a TEDX talk on energy, and advises USC ASTE 527 (advanced space projects program). He has been interviewed for radio, professional organizations. podcasts and corporate events. He was recently interviewed by the radio program Steel on Steel on satellites and high altitude balloons that will track all movement in many parts of the USA.

He fundraises for various high impact technology companies and has worked in computer technology, insurance, healthcare and with corporate finance.

He has substantial familiarity with a broad range of breakthrough technologies like age reversal and antiaging, quantum computers, artificial intelligence, ocean tech, agtech, nuclear fission, advanced nuclear fission, space propulsion, satellites, imaging, molecular nanotechnology, biotechnology, medicine, blockchain, crypto and many other areas.

See original here:
Anti-Aging Researcher David Sinclair Takes Metformin, NMN ...

David Sinclair on NMN and Epigenetics | | LEAF

Posted on January 25, 2020 by Ashlie Lopez

Dr. David Sinclair, a Professor of Genetics at Harvard Medical School, is one of the most well-known researchers in the field of rejuvenation, and his lab is the beneficiary of a successful Lifespan.io campaign.

Today, Dr. Sinclair is releasing his book on Amazon, Lifespan: Why We Age and Why We Dont Have To, and on Wednesday, September 18, we hosted a special webinar with Dr. Sinclair as well.

David has recently appeared on shows such as Joe Rogan, not once but twice, the David Pakman show, and Tom Bilyeu. At International Perspectives in Geroscience, a conference hosted at Weizmann Institute of Science (Israel) on September 4-5, we had the opportunity to interview Dr. Sinclair about his work and his thoughts on the current state of research.

Back in February, you and a group of 16 researchers in the aging field went to the Academy for Health and Lifespan Research with the aim of promoting aging research, fostering the sharing of knowledge between scientists, and helping to guide governments and other key players in the industry. Could you please tell us a little more about the Academy and its current activity?

The Academy is a founding group of scientists who seek to understand the fundamental causes of aging and how to combat it. We have come together to build a society, a group of leaders around the world who will act as one voice to help shape not just the research, but public policy, future economic effects of the research, and medicines that are going to come from this field.

Do you think that aging is a disease or a syndrome or not? Whats your opinion on that?

Well, first of all, theres no correct answer. There is no law that says somethings a disease and something is not. Currently, the medical definition of a disease is something that causes a dysfunction or disability that happens to less than half of the population. Of course, aging happens to most of the population now, but I think that having a cut-off at 50% is arbitrary. Something that causes decline in functionality and eventual death should be worked on just as vigorously as something that only affects a minority of people.

Do you think that recognizing aging as a disease, in, say, the International Classification of Diseases makes sense in order to accelerate the development of new therapies addressing the root mechanisms of aging?

The World Health Organizations new definition of aging as a condition is helpful, but the real change will come when a leading country says that aging is a disease that can have a medicine approved for treatment. Right now, because aging is not a condition thats agreed upon by any regulator, drugs that may slow or reverse aging, and perhaps extend lifespan, healthy lifespan, for many years, doctors are very hesitant to prescribe those medicines. They follow the rule book. Metformin is a good example of a drug that is relatively safe and cheap and could potentially have a big benefit. But, because aging is not a disease, doctors rarely provide it to their patients until they actually become diabetic.

Basically, that means that the position of the government has to change and then once the government declares sort of a war on aging, then there could be some regulation changes, and then it may come to the point when doctors will be mentally ready to prescribe these drugs, right?

Thats right. Also, if aging is a prescriptable condition, then investment in aging-related drugs or longevity medicines will increase by orders of magnitude. The problem today is because aging isnt a prescriptable condition, drugs have to be developed for other diseases first, with the hope that then theyll be used more broadly.

Currently, medicine treats the symptoms, not the causes, of age-related diseases. Do you think that we might soon reach the point where therapies will be taken in a preventive manner to delay the onset of age-related diseases? What do you think might be the turning point for things to change? Basically, prevention is always a problem, even though its one of the most effective strategies, but we seem to never get there.

Well, theres a subset of the population, particularly in the US, but increasingly around the world, who are using the internet to educate themselves and are trying to take action before they become sick. Sometimes with medical supervision, sometimes not. Its a grassroots movement right now; for it to become mainstream, the regulations would have to change so that doctors can feel comfortable prescribing medicines to prevent diseases. But, if we dont change, then we will continue to practice whack-a-mole medicine and only treat one disease at a time after its already developed.

You travel the world a lot. Is there a country that you think is more forward-thinking in how aging is viewed and might take the first move to define aging as a directly treatable condition?

There are a few; the leading contenders right now are Australia, Singapore, and then the US and UK are also talking about it. The first country that does take this first bold step will reap the rewards of that with more investment and, of course, an increasingly productive and healthy population.

You name the countries that seem to have the highest life expectancy, actually. Do you think that its related to the understanding that the problem of population aging is becoming severe enough?

Thats exactly right. The countries that have a problem with the healthcare of the elderly have to do something because of the increased amount of elderly will only continue to raise the percent of GDP those countries spend; right now the US already spends 17%. Theyre not getting any younger, and their life expectancy isnt changing. So, for the US to really make progress, they need a new approach to medicine.

Lets talk a little bit more about your work. You are very well known for your work with NAD+ and its precursors; were often asked whether NR or NMN is better. However, the data seems to suggest that different precursors are more or less efficient in a tissue- or organ-dependent manner. Would it be fair to say that rather than asking which is better, we should instead consider these differences and that both may have their place?

Theyre very similar molecules, and both have been shown to provide a variety of health benefits in mice. That doesnt mean either of them will work to slow aging in humans, and thats why placebo-controlled clinical trials are required to know if one of them, or both of them, will work in certain conditions.

There has been a great deal of debate over the ability of NMN to pass through the plasma membrane to reach the interior of the cell. However, you and your team recently showed that under certain conditions, NMN can indeed enter the cell via a previously undocumented transporter without the need to change back to NR. Have there been any further developments with this? In particular, what does this mean for the efficiency of NMN, given its close proximity to NAD+ in the salvage pathway?

The NMN transporter was recently published by Shin Imais group; I wrote a commentary about it. Im aware of work thats not yet published by a few different labs, looking at how these molecules travel through the body of a mouse. The conclusion is that some tissues have transporters, some dont. It can even vary depending on where in the gut youre talking about. I think, in the end, whats going to happen, like most areas of science, is that everybodys right; it just depends on what youre talking about.

There is a number of human trials in progress for NMN, including one at Brigham and Womens Hospital. Can you tell us anything about that, and when might we expect to see some results?

Those studies began over a year ago, and they are currently Phase 1 safety studies in healthy volunteers. Next year, the plan is to test the pharmaceutical product in a disease area, most likely a rare disease, but also in the elderly to see if we can recapitulate some of the results weve seen in mice, such as increased blood flow and endurance.

Another area that you are involved in is partial cellular reprogramming to reverse age-related epigenetic alterations in cells and tissues. This is a topic that we have written about in the last year or two. Given the success of Belmonte and his team, and the enthusiasm for the approach in general, it really seems to have great potential. Can you please tell us a little bit about this approach and the approach that you are taking and how youre progressing so far?

For 20 years, weve been working on epigenetic changes as a cause of aging, starting with work in yeast and now in mammals. Weve developed viral vectors and combinations of reprogramming factors that appear to be much safer than the Belmonte work, and weve used them to reprogram the eye to restore vision in mice with glaucoma and in very old mice.

Some people argue that epigenetic alterations are similar to the hands of a clock and they only reflect aging, making them not an underlying cause but rather a consequence; do you consider them a cause or a consequence, and when partial programming is initiated, should it be considered to be actual rejuvenation?

Currently, it is believed that the clock is just an indicator of age and not part of the actual aging process, but our recent work that we deposited on bioRxiv strongly suggests that the process of reversing the clock doesnt just change the apparent age of the body, it actually reverses aging itself by restoring the function of the old cells to behave as though theyre young again. Therefore, the clock may not just be telling time; it may actually be controlling time.

That sounds fascinating. So, its actual rejuvenation, right?

Its early days, but this appears to be as close to rewinding the clock and rejuvenating at least parts of the body than anything that weve worked on before.

Back in 2016, when Belmonte and his colleagues demonstrated that partial cellular reprogramming in mice was possible, he estimated that such approaches might reach the public in the next decade. Do you think that we are on track for this to happen?

Were now more than on track. Were actually ahead of schedule. We found an apparently safe way to reprogram tissues, complex tissues, and there are at least two companies now expecting to start clinical trials within the next two years in humans.

Can you tell us a little bit more about that, or is that secret for a while?

One of the companies is called Iduna, and I formed this company with Steve Horvath, Belmonte, and Manuel Serrano in Spain. We have the funding to start a clinical trial next year.

Partial reprogramming is altering ourselves at the cellular level; how do you think the general public might react to such an idea, in your view? Is this going to be a real hurdle to getting people on board with using these treatments?

I found that everyone who hears these results of the Belmonte lab and of my lab is extremely excited because its a very simple but powerful concept of rewinding the clock, and I dont know of anybody who has said that we shouldnt go faster in trying to develop this technology.

In general, whats your usual way of overcoming the initial skepticism regarding the idea of healthy life extension? Because there is this problem with life extension, that people sometimes react weirdly to it.

Ive faced that my whole career since I started; theres always going to be a group of individuals who dont believe that humans are capable of certain things. It was the same with flying back in the early 20th century. I think we know enough now about how aging works and how to slow it and possibly reverse it that its going to be possible in our lifetimes to have a big impact on our healthspan and probably lifespan. Anybody who thinks that its not doesnt know how fast science is moving.

Whats your usual way to deal with skepticism; do you have some favorite arguments?

Mostly, I just go back to the lab and do better research and let the data speak for itself. There are a lot of people who wont be convinced until they see the actual experiments redone many times. What Ive done in the past two years is Ive put all my ideas and the advances in the field into a book, so Im hoping that this book will convince the skeptics or at least make them think hard about whats possible with their lives, what they can do now, and what soon should become possible.

Wonderful. Actually, my next question was about this book; could you please tell us a little bit more about it and what the readers should look forward to.

Lifespan takes the reader on a journey through history, looking at the endeavor of humans to try to live longer and using that historical perspective to look at todays situation and project into the future. The book also takes readers on a journey through the very cutting edge of aging research and things that the reader can do right now to take advantage of these new discoveries in their daily lives with changes in their daily activity, what they eat, when they eat, but also medicines that are currently available on the market that may extend lifespan. The last chapter is about where we are headed, what are the medicines that are in development, and then when these drugs become available, what does the world look like? Is it a better place or a worse place, and how will our lives change?

Wow, that sounds like a book that I would really like to read. You look pretty amazing for being 50 years old. Im 40, and I think you look better than me. Are you doing something to support your health, to feel better, to be more productive and to age slowly?

Im doing an experiment right now in my body. My father, my wife, and my dogs. Its voluntary, of course; my brother recently complained that he was being treated as the negative control in the experiment. I believed in the research and known the risks to be low, so, starting with resveratrol in 2003, I started taking that and Im still taking it, and Ive added to that NMN and some metformin as well. I try not to eat too much. I should exercise more. What I do, and what Ive learned works for me, and for members of my family, is also written down in detail in my book. So, if people would like to know it, they can read it.

Finally, is there a question that no one ever asks you and that you would like us to ask?

Am I afraid of dying?

Are you?

No.

Why not?

Ive been in situations where I thought I could die, planes that have lost their control, that kind of thing. I dont get nervous; Im not worried about that. The reason that Im doing what Im doing is Id like to leave the world a better place than I found it. Im also very curious, Id like to see what we can discover and what the future holds for all of humanity, not just for longevity, but the future of the planet. See if we can point humanity in the right direction and away from the bad scenarios that we seem to be on right now.

We would like to thank Dr. Sinclair for taking the time to make this interview with us and for answering our questions.If you would like to learn more about his work, you may be interested in watching the special webinar we did with Dr. Sinclair in September 2019 which you can see below.

Read this article:
David Sinclair on NMN and Epigenetics | | LEAF

Brave Cashel Community School get the better of St Augustine’s to set-up a Munster hurling final clash with Doon – TipperaryLive.ie

Posted on January 28, 2020 by Ashlie Lopez

Munster Under-19B Post-Primary Schools Hurling Championship Semi-FinalCashel Community School 4-16 St Augustines (Dungarvan) 3-16

Sen Treacy Park was the venue for this semi-final with the conditions cool, but dry. If the conditions were on the chilly side the large crowd in attendance were not short of entertainment as both teams played out a dramatic game featuring thirty-nine scores and seven goals.

The first half was a tight and tense affair with both sides finding space and time on the ball hard to come by.

The Dungarvan school opened the scoring with points from the lively Willie Beresford and Johnny Bourke. Cashel responded with a free, but the Waterford men extended the lead back out to two with a fantastic score from Sam Fitzgerald. Cashel then hit the front with a flurry when hitting 1-2 during a three-minute blitz with the goal coming from Ben Ryan who reacted quickest when an effort at a point came down off the upright.

These scores settled Cashel, but a pair of Niall Buckley frees saw Augustines tie the game (1-2 to 0-5) with twenty-two minutes on the clock.

Both teams exchanged points from then until half-time before Stephen Browne slotted a good point, the other scores all came from dead balls.

The teams headed for the dressing rooms all square (1-6 to 0-9).

SECOND HALF

Cashel opened the second half full of purpose and intent. The Tipperary men hit an uninterrupted 2-3 during a twelve-minute blitz with the goals coming from Kevin Cleary and Conor ODwyer as well as a fine point form the dynamic Euan Ryan.

Daniel Moloney and ODwyer were now to the fore in Cashel's forward line and were helped by the movement of Cathal Quinn to leave the scoreline reading 3-9 to 0-11 points after forty-four minutes.

The men from the south coast did not roll over, however, and crept back into the game thanks to points from Buckley and Burke raising green flags - the second coming from a 21-yard free which saw Buckley take his tally to 1-8. The sides were now (3-11 to 2-14).

This Cashel team knew how to respond. A long-range free was batted out and the lightning fast reactions of Stephen Browne saw him rattle the net to reassert his side's lead. ODwyer dissected the posts with a free to give Cashel a much needed cushion going into the last ten minutes.

The drama did not end there though with Johnny Burke firing the game's seventh goal to claw his team back into the game (4-13 to 3-15) with five minutes of normal time remaining.

It was from here on that the large crowd really saw the true character of this Cashel team as their never-say-die attitude came to the fore.

Cashel kicked for home as Murphy won another crucial free and sub Reuben Bourke made a powerful run to set up the final score which sealed his teams passage to the Munster final.

Cashel had leaders all over the park and not least with defenders Ben Loughman, Toms Bourke, Brian g ODwyer, Conor Farrell and Callum Lawrence all contributing hugely. The athleticism and energy of Jamie Duncan was admired by all while Jack Currivan in goal worked many of his puck-outs to build attacks for his team. Captain Lorcan Carr and Euan Ryan linked play between defence and attack while also working tirelessly. All six starting forwards finished up on the score sheet which shows the variety of threat this team contains.

MUNSTER FINAL

Cashel Community School will take on Scoil na Tronide Naofa, Doon in the Munster Under-19B Post-Primary Schools Hurling Championship final on Saturday, February 15 at Leahy Park in Cashel when the prestigious Corn Thomais Mhic Choilm will be on the line.

The Doon team, which features eight Tipperary players from Cappawhite and ire g Annacarty, got the better of Borrisokane Community College in the semi-finals (3-21 to 2-15) while Cashel Community School proved too strong for St Augustines (4-16 to 3-16).

In the quarter-finals Cashel Community School accounted for Causeway Comprehensive (1-22 to 2-18) while the Tipperary outfit have also beaten Rice College, Ennis (1-17 to 0-8) and Coliste Chrost R, Cork (7-21 to 0-5) during their campaign.

Meanwhile Scoil na Tronide Naofa, Doon proved too strong for Scoil Phobal Roscrea (1-32 to 4-20) in the quarter-finals and Abbey CBS (1-16 to 1-15) in an earlier round of the competition. The Limerick school did lose to St Augustine's (2-8 to 1-13) during the group phase, but re-grouped before surging into the provincial decider.

MATCH DETAILS

Cashel Community School: Jack Currivan (Golden-Kilfeacle), Conor Farrell (Knockavilla Kickhams), Toms Bourke (Boherlahan-Dualla), Jamie Duncan (Knockavilla Kickhams), Lorcan Carr (Knockavilla Kickhams), Ben Loughman (Knockavilla Kickhams), Brian g ODwyer (Rockwell-Rosegreen), Euan Ryan (Boherlahan-Dualla), Callum Lawrence (Cashel King Cormacs), Ben Ryan (Knockavilla Kickhams), Daniel Moloney (Cashel King Cormacs), Stephen Browne (Knockavilla Kickhams), Cathal Quinn (Cashel King Cormacs), Conor ODwyer (Cashel King Cormacs), Kevin Cleary (Rockwell-Rosegreen). Subs: James Murphy (Boherlahan-Dualla) for B Ryan (40th), Adam Ryan (Rockwell-Rosegreen) for Cleary (50th), Reuben Bourke (Knockavilla Kickhams) for Carr (55th), Ned Ryan (Boherlahan-Dualla) for Farrell (60th). Panel Members: Ciarn Moroney (Fethard), Jack Breen (Knockavilla Kickhams), Michael OConnor (Boherlahan-Dualla), Ben Currivan (Golden-Kilfeacle), David Sinclair (Golden-Kilfeacle), Piric Brosnan (Cashel King Cormacs), Darragh Lacey (Boherlahan-Dualla), John Marnane (Rockwell-Rosegreen), Sen Ryan (Rockwell-Rosegreen), Eoghan Murphy (Cashel King Cormacs), Christopher Geraghty (Rockwell-Rosegreen), Ross Whelan (Cashel King Cormacs) and Michel Quinlan (Fethard).

Continue reading here:
Brave Cashel Community School get the better of St Augustine's to set-up a Munster hurling final clash with Doon - TipperaryLive.ie

The Race To Find A Cure For Aging – Medium

Posted on January 1, 2020 by Ashlie Lopez

We want to look & feel young again, and every year we spend hundreds of billions of dollars on beauty serums, cosmetic surgery, and exotic supplements in the hopes of appearing more vibrant, healthy, and desirable.

All of those products, procedures & pills only cover up the symptoms of aging they do nothing to address the cause. While medicine does help us to live longer, at best it has only slowed the ravages of time, and an aging population is driving demand for alternatives to the gradual decline into senescence.

Aging, once thought to be inevitable, is being challenged. For the first time in history, biomedical innovators are starting to view it in a disease model, and not as an inevitability of life and medical science is working to find a cure.

Here are three stories of people from different walks of life who share a singular goal theyre actively working to extend their own lifespans, and sharing what theyve learned on how to achieve it:

Dr. David Sinclair says the solution is to get your NAD+ levels up and hes offering detailed, practical advice on how to do it. In lengthy interviews with Joe Rogan & Rich Roll, as well as his recent book, he discusses the health benefits of intermittent fasting, limiting sugar & red meat, and eating plenty of vegetables but for Sinclair, thats only the beginning.

Sinclair is an award-winning Australian biologist, professor of genetics, and Founding Director of the Paul F. Glenn Laboratory for the Biological Mechanisms of Aging at Harvard University.

His team of 30+ scientists is deeply engaged in studying the mechanisms involved with aging & senescence, and treatments to potentially reverse them. One of the promising life-extension supplements theyve identified is Metformin an inexpensive blood sugar medication that may extend the human lifespan by as much as 10%.

In addition to Metformin, Sinclair is bullish on the prospects of NMN (nicotinamide monomucleotide) for life extension. This vitamin B-3 derivative converts easily into NAD+ inside your cells, which is claimed to improve cellular function and offer rejuvenating effects seen in human clinical trials.

Sinclair claims to have reversed aging in lab mice, and also claims to have knocked more than two decades off his biological age, as well as boasting online that he has the lung capacity, cholesterol and blood pressure of a young adult and the heart rate of an athlete.

If hes right, aging can reversed with NAD+ boosting supplements and thats a big step in a cure for aging and the diseases that come with it.

Others, like Elizabeth Parrish, the CEO of BioViva Sciences, have taken a different route: she underwent experimental gene therapy to lengthen her telomeres & reduce muscle wasting back in 2016, and claims her health has improved since the treatment.

According to Wikipedia, independent testing by SpectraCell Laboratories had revealed Elizabeth Parrishs leukocyte telomere length had been extended from 6.71kb to 7.33kb but in 2018, she reported further lengthening in her telomeres up to 8.12kb, along with an overall growth in muscle mass.

A telomere is a region of repetitive nucleotide sequences at the end of each chromosome that protects it from damage and telomeres get shorter as we age, leading to a variety of aging-related diseases. The initial 10% increase of Parrishs telomeres has been roughly compared to her cells becoming 20 years younger.

However, critics such as Dr. Bradley Johnson at the University of Pennsylvania have questioned her results, stating, Telomere length measurements typically have low precision with variation in measurements of around 10 percent, which is in the range of the reported telomere lengthening apparently experienced by Elizabeth Parrish.

Meet Jim Green, patient zero in a one man experiment in radical anti-aging. He lacks the Sinclair teams funding and cant bioengineer retroviral delivery systems like the Parrish team, but what he lacks in budget he makes up for in courage, innovation & perseverance.

A few years back, Jim decided to tackle aging head-on, and started doing intense research into published scientific papers on aging, cellular senescence, and supplements that led him to a rigorous health regime that he claims has literally reversed his aging.

Jims published a collection of links and notes to all of his papers online, and from talking with him personally several times I can tell you that hes been more than diligent about his research. Josh Mitteldorf also interviewed him recently, and in that interview Jim talked at length about his use of first a nutraceutical called TA-65 and later Astragalus Root Extract as a telomerase activator to give new life to old cells.

Jim has taken the hard road: consuming copious amounts of Astragalus extract along with countless other supplements and a daily exercise routine thats visibly reversed most signs of his aging including his seeing his gray hair regain its youthful color (no, he doesnt dye it, thats natural).

Rather than trying to hide the signs of aging with makeup or plastic surgery, innovators like Sinclair, Parrish & Green have taken action to turn back the clock in the hopes of not only living longer but also living better.

Sinclair has spoken numerous times about aging leading to a tragic loss of human capital & potential that up until now weve taken for granted, but if the research that these innovators are pursuing bears fruit, then it may no longer be our inevitable fate.

Whatever the results of their experiments may ultimately be, their research alone is a testament to our shared desire to stop the sands of time from passing & make the most of every moment that we have.

See the rest here:

The Race To Find A Cure For Aging - Medium

Hard work and dedication honored – Union Daily Times

Posted on January 23, 2020 by Ashlie Lopez

UNION COUNTY The year 2019 was a busy and challenging one for the Union County Sheriffs Office which earlier this month honored its employees at its Annual Breakfast/Awards Banquet during which Sheriff David Taylor reviewed the year and those challenges as well as a continuing problem his office faces.

The banquet was held on Wednesday, January 8, and the employees of the Sheriffs Office were treated by Taylor to breakfast in recognition of their hard work and dedication during 2019.

As in previous years, awards were presented to Sheriffs Office personnel who excelled during the preceding year. Those receiving awards for excelling in the performance of their duties in 2019 were:

Major John Sherfield and Dr. John Flood Special Response Team Award

Deputy Kristen Spencer Deputy of the Year

Investigator Roxie Belue Investigator of the Year

911 Dispatchers Robert Garner and Nikia Brannon Dispatchers of the Year

A Year In Review

Like its predecessors, this years banquet was also a time for taking stock of the previous year, and Taylor did just that, giving a detailed presentation of A Year in Review.

Shootings

Violence, including violence involving law enforcement personnel, is something all law enforcement agencies must deal with as they serve and protect their respective communities and that was the case in 2019 for the Sheriffs Office which had to deal with two officer involved shootings. In his remarks, Taylor said that the number of officer involved shootings in 2019 was unprecedented for his office, but is a reflection of the realities of modern day society.

This is a sign of the times we are living in today, Taylor said. I cannot remember ever having this to happen in the history of Union County.

Investigations

The investigation of crime is one of the major responsibilities of law enforcement agencies and there was plenty for the Sheriffs Office to investigate in 2019, just not quite as much as in 2018.

Taylor said that the number of cases assigned to investigators of the Sheriffs Office declined slightly from 730 in 2018 to 705 in 2019.

Though the number of cases needing to be investigated declined between 2018 and 2019, Taylor reported that the Sheriffs Office saw a significant increase when it came to illegal drugs with 7,514 grams of Methamphetamine seized in 2019 compared to 252 grams in 2018. The amount of Heroin seized by the Sheriffs Office also increased, going from 9 grams seized in 2018 to 49 grams seized in 2019.

The amount of overall crime is symbolic to the amount of drug use in the county, Taylor said.

Special Units

2019 was also a challenging time for the special units of the Sheriff Office: the Special Response Team (SRT) and Bloodhound Unit and K-9 Drug Unit and their deployments during the year.

Taylor the SRT was deployed 10 times in 2019 compared to 7 in 2018 and he said he believes that in the future the SRT will grow in personnel and call-for-service due to the volatile times we are living in.

As for the Bloodhound Unit, Taylor said that in 2019 it was deployed 37 times, up two from 35 deployments in 2018.

These units stay extremely busy throughout the year, Taylor said. If they are not out running calls then they are training.

Of the 37 deployments in 2019, Taylor said 23 resulted in successful captures compared to 17 in 2018. In addition, Taylor said the Bloodhound Unit also recovered 4 weapons and seized $10,000 in currency in 2019.

Concerning the K-9 Drug Unit, Taylor said it was only deployed 14 times in 2019 compared to 51 in 2018. He said this was due to the handler assigned to the unit leaving in early 2019 and the Sheriffs Office having to train and certify another deputy to take over.

Civil Papers And Arrest Warrants

The year also saw an increase in Civil Papers and Arrest Warrants.

In 2019, we served 3,599 Civil Papers versus only 3,520 in 2018 while warrants were up slightly, Taylor said. In 2019, we served 1,828 Arrest Warrants compared to 1,646 in 2018.

While he praised the efforts of all of his deputies for their work serving those Civil Papers and Arrest Warrants, Taylor singled out Deputy Russell Roark for special praise.

Deputy Roark does an outstanding job serving papers for the Sheriffs Office, Taylor said. His knowledge of people helps because he is able to connect with them and locate people that otherwise dont want to be found.

911

The Union County Emergency Services/911 Dispatch Center is also part of the Union County Sheriffs Office and 2019 was a very busy year for it as well even though, as Taylor pointed out, the actual number of calls and dispatches were down slightly from 2018.

In total, we dispatched 33,533 calls for the Sheriffs Office, City Public Safety, EMS, Union County Fire, and Highway Patrol, Taylor said. These numbers were down from 36,204 in 2018.

Our dispatchers answered a total of 69,927 calls through the 911/Administration lines last year, he said. During 2018 they answered 73,392 calls.

Losing Personnel

Taylor concluded the program by thanking the personnel of the departments of his office for all their hard work and dedication to the citizens of Union County, but also pointed out that his office is having trouble retaining trained personnel.

I know that each of you are overworked and underpaid and hopefully this will be addressed by county council in the near future, Taylor said. We are constantly losing trained personnel to other agencies due to low pay.

The banquet was then closed with a prayer offered by Union County Councilman David Sinclair and Taylor offered his best wishes to all those in attendance.

Photo courtesy of the Union County Sheriffs Office Union County Sheriff David Taylor presents Investigator Roxie Belue with the Investigator of the Year Award for 2019. Belue was one of several Sheriffs Office employees to receive awards for their service in 2019 at the Sheriffs Offices Annual Breakfast/Awards Banquet held January 8.

Photo courtesy of the Union County Sheriffs Office Union County Sheriff David Taylor presents 911 Dispatcher Robert Garner with the Dispatcher of the Year Award for 2019. Garner was one of several Sheriffs Office employees to receive awards for their service in 2019 at the Sheriffs Offices Annual Breakfast/Awards Banquet held January 8.

Photo courtesy of the Union County Sheriffs Office Union County Sheriffs Office Investigator Scott Coffer (left) presents Major John Sherfield (right) with the Special Response Team Award for 2019. Sherfield was one of several Sheriffs Office employees to receive awards for their service in 2019 at the Sheriffs Offices Annual Breakfast/Awards Banquet held January 8. Dr. John Flood, a volunteer, was also honored with the Special Response Team Award but was unable to attend the banquet.

Photo courtesy of the Union County Sheriffs Office Union County Sheriff David Taylor presents Deputy Kristen Spencer with the Deputy of the Year Award for 2019. Spencer was one of several Sheriffs Office employees to receive awards for their service in 2019 at the Sheriffs Offices Annual Breakfast/Awards Banquet held January 8.

Photo courtesy of the Union County Sheriffs Office Union County Sheriff David Taylor presents 911 Dispatcher Nikia Brannon with the Dispatcher of the Year Award for 2019. Brannon was one of several Sheriffs Office employees to receive awards for their service in 2019 at the Sheriffs Offices Annual Breakfast/Awards Banquet held January 8.

UCSO employees recognized; Sheriff reviews 2019

This story courtesy of the Union County Sheriffs Office.

Read the original:
Hard work and dedication honored - Union Daily Times

#27 – David Sinclair, Ph.D.: Slowing aging sirtuins, NAD …

Posted on November 23, 2019 by Ashlie Lopez

In this episode, David A. Sinclair, Ph.D., a Professor in the Department of Genetics at Harvard Medical School and co-Director of the Paul F. Glenn Center for the Biological Mechanisms of Aging, provides insight into why we age and how to slow its effects based on his remarkable work on the role of sirtuins and NAD in health and diseases. He also presents the case that stabilizing the epigenetic landscape may be the linchpin in counteracting aging and disease.

Subscribe on: APPLE PODCASTS | RSS | GOOGLE | OVERCAST | STITCHER

Check out this post to see an example of what the substantial show notes look like. Become a member today to get access

Become a Member

David A. Sinclair, Ph.D. is a Professor in the Department of Genetics at Harvard Medical School and co-Director of the Paul F. Glenn Center for the Biological Mechanisms of Aging.

He is best known for his work on understanding why we age and how to slow its effects. He obtained his Ph.D. in Molecular Genetics at the University of New South Wales, Sydney in 1995. He worked as a postdoctoral researcher at M.I.T. with Dr. Leonard Guarente where he co-discovered a cause of aging for yeast as well as the role of Sir2 in epigenetic changes driven by genome instability. In 1999 he was recruited to Harvard Medical School where his laboratorys research has focused primarily on understanding the role of sirtuins in disease and aging, with associated interests in chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, and cancer. He has also contributed to the understanding of how sirtuins are modulated by endogenous molecules and pharmacological agents such as resveratrol.

Dr. Sinclair is co-founder of several biotechnology companies (Sirtris, Ovascience, Genocea, Cohbar, MetroBiotech, ArcBio, Liberty Biosecurity) and is on the boards of several others. He is also co-founder and co-chief editor of the journal Aging. His work is featured in five books, two documentary movies, 60 Minutes, Morgan Freemans Through the Wormhole and other media.

He is an inventor on 35 patents and has received more than 25 awards and honors including the CSL Prize, The Australian Commonwealth Prize, Thompson Prize, Helen Hay Whitney Postdoctoral Award, Charles Hood Fellowship, Leukemia Society Fellowship, Ludwig Scholarship, Harvard-Armenise Fellowship, American Association for Aging Research Fellowship, Nathan Shock Award from the National Institutes of Health, Ellison Medical Foundation Junior and Senior Scholar Awards, Merck Prize, Genzyme Outstanding Achievement in Biomedical Science Award, Bio-Innovator Award, David Murdock-Dole Lectureship, Fisher Honorary Lectureship, Les Lazarus Lectureship, Australian Medical Research Medal, The Frontiers in Aging and Regeneration Award, Top 100 Australian Innovators, and TIME magazines list of the 100 most influential people in the world. [medapps.med.harvard.edu]

David on LinkedIn: David A. Sinclair, Ph.D. A.O.

David on Twitter: @davidasinclair

(Boston, MA - 3/23/17) David Sinclair, director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, discovered how to reverse aging in mice, Thursday, March 23, 2017. Staff photo by Angela Rowlings.

See more here:

#27 - David Sinclair, Ph.D.: Slowing aging sirtuins, NAD ...

Dealer Jailed After Raid Uncovers 44k of Grugs – Daily Record

Posted on November 30, 2019 by Ashlie Lopez

A drug dealer was left counting the cost this week after police seized almost 44,000 worth of illicit substances following a raid on his flat at a Perth housing estate.

Perth Sheriff Court was told officers took possession of more than 1000 ecstasy tablets, in excess of 1300 grammes of cannabis and nearly 2000 grammes of amphetamine when they went to Kamil Morawaskis housing association flat in the Fairfield area of the city.

They also discovered more than 5000, stuffed in envelopes and hidden under a mattress, as well as other cash and euros totalling more than 500.

The 31-year-old was jailed for 54 months after he admitted being concerned in the class A and class B drugs at his first floor flat in McCallum Court, Perth, between January 31 and July 31, 2019.

His lawyer, David Sinclair, said extradition was awaiting him at the conclusion of the Perth proceedings and he would be returned to Poland to complete his sentence.

Depute fiscal Eilidh Robertson said the prosecution had also raised proceeds of crime action against him in a bid to claw back some of the cash he had dishonestly obtained.

An earlier motion to forfeit the cash seized by police was withdrawn.

You may find CBD/Hemp products that are allowed in all 50 states here
(https://www.mthfrdoctors.com/product-category/cbd-hemp-products/)

Imposing the lengthy jail term, Sheriff Foulis noted Morawski had a previous conviction for a cannabis offense in his homeland.

If the matter had gone to trial, there would have been a very real prospect he would have been remitted to the High Court for sentence where lengthier jail terms can be imposed.

But he added: I am persuaded - just - that it can remain in this court.

You have held your hands up and accepted responsibility at the earliest stage...and you did not shy away from taking responsibility for your actions.

Nor, indeed, did you try to mask the reason for your actions in any way.

Such honesty is, bluntly, refreshing.

Mr. Sinclair explained his client had been involved in the drugs scene for around six months.

Any drugs sold were to people that he knew - predominantly in the Polish community - and others that he knew at the local level.

He has clearly acknowledged he was seeking to improve his family life but took the short way of doing so.

He recognizes, with the benefit of hindsight, this was a huge mistake and he regrets hes put his family in this position.

The court heard previously that police obtained a drug search warrant which they executed on July 31.

The accuseds house was searched and several tubs containing cannabis, ecstasy tablets and amphetamines were discovered.

Officers also found drugs paraphernalia, including a tick list, which indicated to officers he was supplying drugs on a commercial basis.

A total of 5140, contained in envelopes hidden under a mattress, along with 320 in cash, found on top of a chest of drawers, and 265 euros, discovered in a dressing table, were also seized.

The following substances were recovered: a total of 1120 class A ecstasy tablets, with a maximum illicit value of 11,200; 1309.76 grammes of Class B cannabis, worth 13,090; and 1945.08 grammes of class B amphetamines, with a street value of 19,450.

When interviewed by police, Morawski admitted he was a drug dealer and that he had been selling cannabis, ecstasy and amphetamine for around six months for financial gain.

Sheriff Foulis said the amount of drugs and cash recovered represented only a snapshot of the position at July 31.

He added: It does not - and cannot - give any indication as to the value of drugs which passed through your hands between January 31 and July 31 of this year.

He stated, however, that it would not have been insubstantial.

The jail term was backdated to August 1 when Morawaski was first remanded.

A preliminary hearing to consider the proceeds of crime action has been fixed for February 18.

Link:

Dealer jailed after raid uncovers 44k of drugs - Daily Record

Lazarus Effect: Sixteen-year study by Dr. Leis resulted in recovery from West Nile for Dr. Bush – Northside Sun

Posted on December 21, 2019 by Ashlie Lopez

To her long list of medical accomplishments, Jackson ob-gyn Dr. Freda McKissic Bush can now add celebrated research subject.

She recently became the subject of a scientific paper entitled: Lazarus Effect of High Dose Corticosteroids in a Patient with West Nile Virus Encephalitis: A Coincidence or a Clue?

Published in Frontiers of Medicine, the article is co-authored by neurologists Dr. Art Leis of Methodist Rehabilitation Center (MRC) and Dr. David Sinclair of Mississippi Baptist Medical Center.

While Bushs recovery is the focus of the treatise, its a bit of poetic license to compare her experience with that of the Biblical Lazarus. She was not raised from the dead.

But the 71-year-old retired physician said she was on my way out.I was going to die, it was as simple as that, she said.

Bush was suffering from West Nile virus (WNV) encephalitis, a swelling of brain tissue that is one of three neuro-invasive forms of WNV infection.

In the years since WNV first arrived in the United States in 1999, the Centers for Disease Control (CDC) and Prevention has recommended treating infections with only standard supportive care.

But during 16 years of studying neuro-invasive forms of the disease, Leis came to favor prescribing high-dose steroids for the most severe forms of the disease.

The approach seems to quell the bodys immune system attack of inflammation on healthy tissue. But Leis was cautious about using it at first. It is counter-intuitive to weaken the immune system when a patient has encephalitis, Leis said.

To be on the safe side, Leis initially delayed steroid treatment until at least two weeks from the onset of WNV. By 2018, hed begun to rethink that timeline.

The CDC had found that WNV rapidly cleared the body in people with normal immune systems. And Leis own experiences with immune-suppressive treatments had not raised any red flags.

To my knowledge we dont have any cases where treatment with high-dose steroids initiated acute worsening that would suggest the virus had spread, Leis said.

When he was consulted on Bushs case in July 2018, Leis believed her condition demanded an aggressive approach, as did Sinclair.

She was in the ICU in a semi-comatose state for a while, Sinclair said. It was very clear her whole brain was involved and the risk of disability at that point was extremely highif not death.

Leis and Sinclair say they sought to publicize Bushs case because they believe scientific scrutiny of the approach is needed.

Were trying to look at deciding whether patients will improve spontaneously or if steroids are helpful, Sinclair said. This really needs to be studied in a manner where we have a control group who receives the current standard of care intervention.

In the meantime, Leis will continue to contribute as a scientist who has long been on the front lines of WNV research.

In 2002, he and fellow MRC scientist Dr. Dobrivoje Stokic were the first in the world to link WNV to a polio-like paralysis. And over the years, MRC has been a valuable resource for physicians treating West Nile virus infection, as well as a support group site for survivors and their families.

Leis knows well the lifelong impact WNV infection can have. In his office is a five-drawer file cabinet full of patient data, as well as thank-you notes from people hes helped.

For those who have the more severe forms of West Nile virus infection, over half have persistent or delayed symptoms, such as severe, disabling fatigue, persistent headaches, sleep disruptions and trouble concentrating, Leis said.

Some even experience disruption of their autonomic reflex system, which controls everything from blood pressure, cardiac rhythm, sweating, bowel and bladder control to gastrointestinal mobility.

Recently, Leis obtained disease-specific privileges at several metro Jackson hospitals, which will make it easier for him to consult with acute care physicians.

And Sinclair, for one, believes theres no one better than Leis to help guide the care of WNV patients.

I think Im one of a dozen young neurologists in the state who look toward his expertise in the area of neuro-virology, Sinclair said. He has cared for the most West Nile virus patients and dealt with the most severe consequences of that illness. Hes someone I could turn to for advice on cases like that.

Like most long married couples, Lee and Freda McKissic Bush are deeply aware of each others moods.

So on the morning of July 17, 2018, Lee quickly realized something was amiss with his normally talkative wife.

The retired ob-gyn barely whispered yes or no to his questions. And she did not look well.

I stopped getting ready for work and starting paying her attention, he said. Her torso was really burning up.

After trying unsuccessfully to reach Fredas doctor, Lee decided to rush her to the emergency room at Mississippi Baptist Medical Center in Jackson.

Much later she would ask him: Why didnt you call an ambulance?

Too slow, he said.

Freda was well-known at Baptist, having delivered babies there since 1987. But when she arrived that morning, none of the staff had ever seen her like thisnearly unconscious and going downhill fast.

Her medical team quickly began a litany of tests. But it would be almost a week before Lee learned the source of his wifes suffering.

She was diagnosed with West Nile virus encephalitis, a life-threatening form of the mosquito-borne disease.

Whats worse, Lee was being told the condition carried no treatment. They said wed have to wait and see what happens. And I said: Thats my wife youre talking about.

The couple had gotten married in 1969 after only three months of dating. In the years since, theyd reared four children, balanced two demanding careers and supported causes they believed in.

What loomed ahead was more opportunities to give back, as well as time to spend with their 11 grandchildren and two great-grandchildren.

Surely, this wasnt to be the end of a union between two people whod shared so muchincluding the challenges of each growing up the fifth of nine children.

An engineer by training and a successful businessman, Lee went into problem-solving mode to save his wife.

He took matters into his own hands and said: Somebody has got to tell me something, Freda said.

After some networking, website searches and phone calls, Lee learned one of the nations foremost West Nile virus researchers worked just down the street at Methodist Rehabilitation Center.

Lee arranged a meeting with Dr. Leis, a senior scientist with MRCs Center for Neuroscience and Neurological Recovery. And hell never forget seeing him for the first time.

He walked into this huge waiting room at Baptist and I said: Here comes my angel doctor. He said: Angel? Why did you call me that? I said: Because you are my angel. He said: I dont know if you know this, but my first name is Angel.

Leis advocated treating Freda with high-dose steroids, but he warned it could be risky.

He said steroids will stop her brain from swelling, but it will also stop her immune systemwhich is kind of dangerous, Lee said.

But Leis said he was willing to take the chance because he knew Lee would provide the close observation Freda would need during steroid therapy.

When anyone would urge Lee to leave his wifes side for a well-deserved respite, hed say: Ill leave when she leaves.

He made a decision that his job was taking care of me, Freda said. He wouldnt go to work, and he slept in a chair.

When I realized how much dedication he had given to me, I boohooed. I was overwhelmed. I tell people if I thought I loved him before, it doesnt compare to now.

As Freda began to regain consciousness, she didnt know who she was or where she was, but she was awake, Lee said.

And he made it his mission to keep her roused. I am playing spiritual music, dancing around and walking around her bed praying, he said.

Baptist staff offered spiritual support, too. Every doctor who came by said were praying for her, Lee said. They would pat me on the shoulder and leave out.

The Bushs adult children also came through for their parents. While their son took over for his dad at NCS Trash and Garbage, his three sisters rotated two-week caregiving shifts. And one of Fredas sisters traveled from Washington, D.C., to lend a helping hand.

Freda spent three weeks at Baptist, including 15 days in ICU. Next came another 24 days at MRC, working on skills to regain her independence.

It wasnt easy for the accomplished physician to acknowledge her deficits.

I spent a lot of time crying, she said. I had already retired from medicine, but I was still very active. I was on a lot of boards and was working with the Medical Institute for Sexual Health in Austin. And to think now I couldnt do anything, couldnt even remember. I spent a lot of time crying because I wasnt me.

Lee, on the other hand, never lost hope.

She is my miracle in slow motion, he said. The best thing for me was seeing in her eyes she was getting better and all the miracle steps in the right direction. When she could look at me and smile and say, I love you. Those were the nuances that kept me going.

Today, Freda continues to progress. And while shes chafing for more independenceshe and Lee laugh that they never spent so much time togethershes grateful for his commitment.

I have to give credit to the Lord, she said He put us together, and he kept us together. I say Im so sorry I got West Nile, but Im so glad God gave me Lee Bush.

More here:

Lazarus Effect: Sixteen-year study by Dr. Leis resulted in recovery from West Nile for Dr. Bush - Northside Sun

David Sinclair supplements and protocol explained NMN …

Posted on November 23, 2019 by Ashlie Lopez

If you watched any of David Sinclair videos you probably noticed that he looks younger than he actually is. When I saw the video it made me think that this guy must be doing something that works for him. I did some research, and that brought me to his Joe Rogan podcast, where he explains exactly what he is doing to stay young.

I would highly suggest that you go watch the video as he gives out a massive amount of valuable information.

I will first give you an overview of all the things he does and then later try to explain how everything comes together

List of things David Sincalir consumes or does

Sirtuins are genes which protect all organisms from deterioration and disease. NMN and Resveratrol are molecules which essentially mimic the effects of the sirtuin genes.

NMN also boosts NAD levels (which sirtuins need to function)

Nicotinamide mononucleotide is a nucleotide derived from ribose and nicotinamide. Like nicotinamide riboside, NMN is a derivative of niacin, and humans have enzymes that can use NMN to generate nicotinamide adenine dinucleotide.

Formula: C11H15N2O8PMolar mass: 334.2192 g/mol

Resveratrol is a stilbenoid, a type of natural phenol, and a phytoalexin produced by several plants in response to injury or, when the plant is under attack by pathogens such as bacteria or fungi. Sources of resveratrol in food include the skin of grapes, blueberries, raspberries, mulberries, and peanuts.

Molar mass: 228.25 g/molFormula: C14H12O3Solubility in water: 0.03 g/LMelting point: 261 to 263 C (502 to 505 F; 534 to 536 K)Appearance: white powder with; slight yellow castSolubility in DMSO: 16 g/L

Metformin, marketed under the trade name Glucophage among others, is the first-line medication for the treatment of type 2 diabetes, particularly in people who are overweight. It is also used in the treatment of polycystic ovary syndrome. It is not associated with weight gain. It is taken by mouth.

Molar mass: 129.1636 g/molFormula: C4H11N5Excretion: Urine (90%)Trade name: Glucophage, otherBioavailability: 5060%Elimination half-life: 48.7 hours

There are 3 pathways related to aging:

Intermittent fasting is an umbrella term for various eating diet plans that cycle between a period of fasting and non-fasting over a defined period. Intermittent fasting is under preliminary research to assess if it can produce weight loss comparable to long-term calorie restriction.

The main idea is that you ideally skip a meal or two, therefore putting your body in a state of starvation which triggers different processes in the body, which are proved to have a broad variety of benefits, some of them include anti ageing benefits.

David recommends performing exercise regularly. He recommends running and doing resistance training.

David especially recommends exposing your body to temperature extremes which force your body to kick start protective mechanisms. He recommends doing a hot sauna immediately followed by cold water submersion.

See the article here:

David Sinclair supplements and protocol explained NMN ...

David Sinclairs anti-aging science | Harvard Magazine

Posted on November 23, 2019 by Ashlie Lopez

Decades of research have shown that calorie restriction extends lifespan and delays morbidity in many small, short-lived species: yeast, spiders, and various fish and rodents. In humans, though, the benefits of calorie restriction are still unproven, and probably less straightforward. And how calorie restriction slows the aging process is still not well understood. The interesting thing about calorie restriction is that we used to think the body was in some way slowing down, maybe in the number of heartbeats or production of free radicals, says professor of genetics David Sinclair. But it turns out thats wrong.When were calorie restricting, what were really doing is telling the body that now is not the time to go forth and multiply. Its time to conserve your resources, repair things better, fight free radicals, and repair broken DNA.

Sinclair believes that a compound found in all living cells, nicotinamide adenine dinucleotide (NAD), could be used to mimic these effects in humans without the starvation or decreased reproductive capacity associated with calorie restriction; his human trials of a therapy that could increase NAD levels are due to begin this month. Meanwhile, a similar compound is already being marketed as a supplement by a health start-up with several distinguished scientists (including three Harvard faculty members) on its advisory boardeven though theres still no evidence that the substance works.

Sinclairs approach is based on a broad view that links diseases of age such as cancer, diabetes, Alzheimers, and heart failure to common cellular processes. His lab aims to understand these processes and then use that understanding to develop medical therapies.

Underlying the wide-ranging benefits of calorie restriction, Sinclair explains, are sirtuinsa group of seven genes that appear to be very important in regulating the aging process. These longevity-gene pathways are turned on by changes in lifestyle such as exercise and calorie restriction, he says. They control a variety of protective processestheres hundreds of things that they do, and we still dont know everything. But they protect the chromosomes, they protect stem cells from being lost, they protect cells from senescing. Sirtuins can be activated by a lack of amino acids or of sugar, or through an increase in NAD. (The compounds level in the body declines with age.)

Earlier this year, research from Sinclairs lab showed that feeding mice nicotinamide mononucleotide (NMN)a related, precursor compound that the body converts into NADmay slow aging in the animals, mimicking the effects of calorie restriction. We get the same effects as exercise or dieting, he says. The mice are leaner, have more energy. They can run further on a treadmill. That research continues, and is poised to be tested in humans: the first stage of the trials of NMN that he was preparing to begin in August at a Harvard-affiliated hospital will test for NAD increases in the blood; after that, he plans to study NMNs efficacy in treating diseases. Sinclair has been taking the compound himself for about a year. Hes reticent about that, to avoid sounding like a kook, but claims his lipid profile has improved dramatically and he feels generally less fatiguedthough he admits this is not scientific.

There is a cautionary note to sound, says Jeffrey Flier, Walker professor of medicine and former dean of Harvard Medical School (HMS). The NAD precursor already on the market as a dietary supplement, nicotinamide riboside (NR), is sold by New York-based Elysium Health, founded by MIT biologist Leonard Guarente, Ph.D. 79, who played a central role in establishing the link between sirtuins and aging, and was Sinclairs doctoral adviser. The company doesnt make any specific claims about aging prevention (legally, it cant); instead, it promotes its product as the one daily supplement your cells need. Flier has criticized the company for using the names of the highly credentialed scientists on its advisory board (featured prominently on its website) to market an unproven product: Elysium is selling pills [without] evidence that they actually work in humans at all, he says, echoing the strongly worded Boston Globeop-ed he wrote earlier this year condemning the companys marketing scheme.

Sinclair, who co-directs the Glenn Center for the Biology of Aging at HMS, is not linked to Elysiumhis clinical trials go squarely down the traditional medical route, rather than through the loosely regulated supplement industry. Thats the contrast, he says. Im taking a pharmaceutical approach, FDA approval. Still, whatever animal research portends about the potential of NAD (and however alluring the promise of a cure for aging), the history of pharmaceutical development suggests its much too soon to expect any benefits for humans. Often molecules may be helpful to animals in a limited set of studies, but then are not shown to be helpful in humans, Flier warns. There are many, many, many examples of that.

Read the original here:

David Sinclairs anti-aging science | Harvard Magazine

#70 – David Sinclair, Ph.D.: How cellular reprogramming could …

Posted on November 23, 2019 by Ashlie Lopez

In this episode, David Sinclair, Ph.D., a Professor in the Department of Genetics at Harvard Medical School and co-Director of the Paul F. Glenn Center for the Biological Mechanisms of Aging, returns to the podcast to discuss the content of his new book, Lifespan: Why We Age and Why We Dont Have To. This conversation focuses on the biological mechanisms involved in what David terms the Information Theory of Aging which provides insights into the clock that determines our aging and to what degree it can be manipulated. Our discussion on aging of course leads us into interconnected topics of epigenetics, sirtuins, cellular senescence, as well as what compounds David is personally taking for his own longevity. Additionally, we discuss the most up to date information related to NAD and longevity by looking at the potential benefits (if any) of supplemental agents (NAD precursors, NR, NMR, etc.) that pose a promise of increasing NAD.

Subscribe on: APPLE PODCASTS | RSS | GOOGLE | OVERCAST | STITCHER

The SIR gene silent information regulator is a gene that controls other genes

The SIR enzyme is the master regulator of this cellular survival circuit

Figure 1. When SIR enzyme proteins detect stress in the cell (e.g. DNA breakage) the protein leaves the silent region to go and repair the DNA. When the problem is fixed, it returns to its original post, silencing genes. Image credit: (Alves-Fernandes and Jasiulionis, 2019)

Overtime, in the back-and-forth of repair SIR genes lose track of which genes should be silenced or not

We have some early evidence from mice that we can actually find that hard disk drive and reinstall the software so that its pristine again and we find that we can actually improve the health quite dramatically in parts of a mouses body. David Sinclair, Ph.D

What does Claude Shannons Information Theory of Communication have to do with aging?

{end of show notes preview}

Check out this post to see an example of what the substantial show notes look like. Become a member today to get access

Become a Member

David A. Sinclair, Ph.D. is a Professor in the Department of Genetics at Harvard Medical School and co-Director of the Paul F. Glenn Center for the Biological Mechanisms of Aging.

Dr. Sinclair is the co-founder of several biotechnology companies (Sirtris, Ovascience, Genocea, Cohbar, MetroBiotech, ArcBio, Liberty Biosecurity) and is on the boards of several others. He is also co-founder and co-chief editor of the journal Aging. His work is featured in five books, two documentary movies, 60 Minutes, Morgan Freemans Through the Wormhole and other media.

David on LinkedIn: David A. Sinclair, Ph.D. A.O.

David on Twitter: @davidasinclair

David on Instagram: davidsinclairphdDavids book website: lifespanbook.com

BOSTON, MA - MAY 16: David A. Sinclair, Professor of Genetics and Director of the Paul F. Glenn Center for the Biology of Aging, poses for a portrait in the lab at Harvard Medical School in Boston on May 16, 2018. (Photo by Craig F. Walker/The Boston Globe via Getty Images)

Continued here:

#70 - David Sinclair, Ph.D.: How cellular reprogramming could ...

Select Page ::