France pulls out of NATO naval mission in the Mediterranean – Politico

NATO did not confirm the letter which was first reported by French paper L'Opinion or Frances temporary withdrawal, and a spokesman referred questions to the French government.

The alliances political leaders have struggled to maintain a display of unity in recent years amid at times vicious infighting, including loud gripes by U.S. President Donald Trump over meager military spending and criticism from French President Emmanuel Macron over lack of coordination and Turkish unilateral actions.

"Its a very clear political move that shines a light on the fundamental ambiguity of an anti-smuggling operation that includes smugglers," the French official said in reference to Turkey. "What we are asking for is a clarification of the rules of behavior."

France, which has received little public support from NATO allies in its escalating conflict with Turkey, is making its return to Operation Sea Guardian conditional on four demands: that NATO allies reaffirm their commitment to the arms embargo; outlaw the use of NATO call signs when ships are on national operations; improve coordination between Sea Guardian and the EU Operation IRINI (which is also meant to enforce the Libya embargo); and the setting up of a mechanism to defuse conflict and avoid incidents among allies.

Turkey has been blocking NATO-EU coordination in the enforcement of the embargo in the Mediterranean and is accused of using the NATO call sign while its ships escort cargo transporting vast amounts of weapons to the U.N.-recognized government led by Prime Minister Fayez al-Sarraj, in contravention of a U.N. arms embargo.

On June 10, the French frigate Le Courbet, operating under NATO command, attempted to inquire about the intended destination of a Tanzanian-flagged cargo ship, the Cirkin, but was aggressively barred from doing so by three Turkish naval ships escorting the Cirkin, according to French officials.

The Cirkin was suspected by NATO Maritime Command of transporting weapons to Libya.

According to French officials, the Turkish ships went as far as flashing their radar lights three times in the space of a few seconds, a manoeuvre that usually precedes the firing of weapons. They also said Turkish sailors were seen wearing bullet-proof vests and standing behind their weapons.

But Turkey disputes that version of events and says the NATO investigation does not back France's claims.

"According to the information that I have [the NATO report] is not conclusive," Turkish Ambassador to France Ismal Hakki Musa told a French Senate hearing on Wednesday. "It appears the NATO experts aren't reaching the same conclusion [as the French]."

On June 17 and 18, French Defense Minister Florence Parly lodged a complaint at a NATO ministerial meeting and only got the support of eight allies out of a total of 30, for its criticism of Turkey's behavior. The U.S. and U.K. notably were not among its supporters.

David M. Herszenhorn contributed reporting.

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France pulls out of NATO naval mission in the Mediterranean - Politico

NATO and the UN hold consultations on COVID-19 response – NATO HQ

NATO and the United Nations held annual talks virtually on Monday (29 June 2020) with a strong focus on the fight against COVID-19.

Since the start of the COVID-19 crisis, we have intensified our cooperation with the UN as we strive to strengthen the resilience of our societies. As part of a global response, NATO is helping the UN with airlift and other critical capabilities that are greatly needed at this time, said NATO Deputy Secretary General Mircea Geoan.

He participated in these talks alongside NATO Assistant Secretary General for Political Affairs and Security Policy Bettina Cadenbach and, on the UN side, Under-Secretary-General for Political and Peacebuilding Affairs Rosemary DiCarlo, as well as Under-Secretary-General for Peace Operations Jean-Pierre Lacroix and Under-Secretary-General for Operational Support Atul Khare.

Marking the 75th anniversary of the UN Charter, NATO and the UN pledged to work together on areas including gendered impacts of the Coronavirus pandemic, specialist medical care, and a range of technical areas.

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NATO and the UN hold consultations on COVID-19 response - NATO HQ

Is the US using its NATO ally Turkey to counter Russia in Libya? – Middle East Monitor

Watching the recent military development in Libya, the obvious question is: does the US have a coherent strategy to counter the fast-growing Russian presence in the North African country? It seems it does not.

The US overall strategy, in the entire Middle East and North Africa, appears to be one of retreat. At best, it is built on shambolic ad-hoc steps, rather than on well-designed, pre-planned, consistent geopolitical ones. President Donald Trump has repeatedly expressed his determination to withdraw from regional wars that previous US administrations have engaged in. From Afghanistan to Syria, the US is down-scaling its involvement, if not leaving hotspots, and refraining from any further engagements. In Syria, for example, Russia appears to be having free hand in its own show of geopolitics, while leaving the peripheries to Turkey.

The Trump administration certainly becomes chaotic under pressure. Former National Security Advisor John Bolton in his book describes an incompetent president consistently failing to grasp world affairs. Trump, conforming to his investor mentality, views geopolitics from a short-term cost-benefit analysis, instead of seeing beyond the horizon in a long-term context.

Libya, after Syria, is becoming a stark example of the US administrations failure to come up with policy options to counter its main adversaryRussia. While the US keeps its publicly-stated position of recognising Libyas Government of National Accord (GNA) as the only authority in the country, it has so far failed to translate this into meaningful prospective. Lately, the US administration seems to prefer supporting Turkeys widening involvement in Libya, than to take action itself.

READ: The Arab Leagues resolution on Libya: Too much ado about nothing

This is becoming evident in the United States Africa Command AFRICOMs increased contact with the GNA in Tripoli. The command is now leading any US efforts to stand up to Russian activities in Libya, at least by exposing them publicly. While Russia continues to deny having any presence in the country, it has been increasingly bolstering General Khalifa Haftars Libyan National Army (LNA)s fighting capabilities.

AFRICOMs top officer, General Stephen Townsend, and the US Ambassador to Libya Richard Norland, on 22 June met the GNAs Prime Minister Fayez Al-Sarraj. Little was said about the visit, but AFRICOMs statement did confirm that violence [in Libya] fuels the potential risk of terrorism and that foreign military interference in Libya is neither welcomed nor helpful. Commander Townsend also pointed to the dangers posed by Russian-sponsored Wagner operations, according to the statement. Wagner mercenaries are fighting on the side of the LNA. A week earlier, AFRICOM, in another statement, published photos of what it alleged were Russian fighter jets landing in Libyas Al-Jufra Airbase to help Wagner fighters.

Last February, the GNAs hawkish Minister of Interior Fathi Bashaga offered the US military a military base in Libya, if interested. However, the US seemed uninterested despite the increasing Russian footprints in the North African country. Bashaga was present during the 22 June meetings in Zuwara, west of Tripoli, but did not confirm whether the US followed up on his questionable offer.

Whatever the Russians are doing in Libya, it does have long-term strategic security connotations. Libya, after all, is minutes away from major NATO surveillance and reconnaissance installations in Southern Italy. NATOs Secretary-General Jens Stoltenberg just last month expressed the alliances concern about the widening Russian presence in Libya.

But the alliance, particularly its biggest member, the US, seems unable to produce a cogent strategy towards Libya, nine years after it helped to destroy the country. If the US like what Turkey, a NATO member itself, is doing in Libya, viewing it as an extension of a NATO mission there, France, another major NATO member, does not. On 29 June, President Emmanuel Macron accused his Turkish counterpart of playing what he called a dangerous game in Libya. Macron is clearly not concerned with the Russian military activities in Libya, but more about Turkey importing Syrian fighters to Libya. Thousands of Syrian fighters have been brought to the conflict by Ankara, in its efforts to ward off the LNAs now failed attack, to unseat the GNA from the capital of Tripoli.

READ: How Haftar squandered his near secure victory, and why

Paris, accused of supporting Haftars LNA, does not share the US view of the situation in Libya when it comes to Turkeys dominant role in the country. France, after all, under former President Nicolas Sarkozy, led the military intervention in Libya in 2011, eventually toppling the late leader Muammar Gaddafi. Now it wants to be part of any future political settlement of the conflict, however, lacking any clear political strategy to do so, in light of both Turkey and Russias role in the oil-rich country.

If the US believes what Turkey is doing in Libya is in the long-term interests of NATO, it is wrong. Turkey has its own agenda, mainly to become a more assertive force in the Mediterranean regionboth economically and militarily. To President Erdogan, Libya is not about countering Moscows influence in North Africa, but more about having a foothold in the country as a gateway to the entire North Africa and beyond. Over the years, Ankara has been pushing its African policies with investments and other economic projects. Libya, apart from its oil riches, as a gateway to Africa, is critical to such policies. In North Africa, Erdogan is clearly favouring political Islamists in the post-Arab Spring era, and Libya is a good starting point after Islamists lost out in both Egypt and Algeria, while still clinging to power in Tunisia.

Foreign policy issues rarely feature in US presidential elections, and this election year is no exception. President Trump, facing re-election in less than five months, is overwhelmed by domestic issues including racism and economic downturn due to COVID-19, and will certainly forget about Libya and NATO altogether. In the meantime, Moscow is winning the geopolitical game NATO started in Libya nine years earlier.

The views expressed in this article belong to the author and do not necessarily reflect the editorial policy of Middle East Monitor.

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Is the US using its NATO ally Turkey to counter Russia in Libya? - Middle East Monitor

Whole-Town Study Reveals More Than 40% of Covid-19 Infections Had No Symptoms – Global Health News Wire

Professor Stefano Merigliano testing a child in Vo

A study of COVID-19 in the quarantined Italian town of V, where most of the population was tested, reveals the importance of asymptomatic cases.

The authors of the new research, from the University of Padova and at Imperial College London, publishedinNature, suggest asymptomatic or pre-symptomatic people are an important factor in the transmission of COVID-19. They also argue that widespread testing, isolating infected people, and a community lockdown effectively stopped the outbreak in its tracks.

The town of V, with a population of nearly 3,200 people, experienced Italys first COVID-19 death on 21 February 2020. The town was put into immediate quarantine for 14 days. During this time, researchers tested most of the population for infection of SARS-CoV-2, the virus that causes COVID-19, both at the start of the lockdown (86 percent tested) and after two weeks (72 percent tested).

The testing revealed that at the start of the lockdown, 2.6 percent of the population (73 people) were positive for SARS-CoV-2, while after a couple of weeks only 1.2 percent (29 people) were positive. At both times, around 40 percent of the positive cases showed no symptoms (asymptomatic). The results also show it took on average 9.3 days (range of 8-14 days) for the virus to be cleared from someones body.

None of the children under ten years old in the study tested positive for COVID-19, despite several living with infected family members. This is in contrast to adults living with infected people, who were very likely to test positive.

As a result of the mass testing any positive cases, symptomatic or not, were quarantined, slowing the spread of the disease and effectively suppressing it in only a few short weeks.

Co-lead researcher Professor Andrea Crisanti, from the Department of Molecular Medicine of the University of Padua and the Department of Life Sciences at Imperial, said: Our research shows that testing of all citizens, whether or not they have symptoms, provides a way to manage the spread of disease and prevent outbreaks getting out of hand. Despite silent and widespread transmission, the disease can be controlled.

The results of the mass testing programme in V informed policy in the wider Veneto Region, where all contacts of positive cases were offered testing. This testing and tracing approach has had a tremendous impact on the course of the epidemic in Veneto compared to other Italian regions, and serves as a model for suppressing transmission and limiting the virus substantial public health, economic and societal burden, added Professor Crisanti.

As well as identifying the proportion of asymptomatic cases, the team also found that asymptomatic people had a similar viral load the total amount of virus a person has inside them as symptomatic patients.

Viral load also appeared to decrease in people who had no symptoms to begin with but later developed symptoms, suggesting that asymptomatic and pre-symptomatic transmission could contribute significantly to the spread of disease, making testing and isolating even more important in controlling outbreaks.

Co-lead researcher Dr Ilaria Dorigatti, from the MRC Centre for Global Infectious Disease Analysis, Jameel Institute (J-IDEA), at Imperial College London, said: The V study demonstrates that the early identification of infection clusters and the timely isolation of symptomatic as well as asymptomatic infections can suppress transmission and curb an epidemic in its early phase. This is particularly relevant today, given the current risk of new infection clusters and of a second wave of transmission.

There are still many open questions about the transmission of the SARS-CoV-2 virus, such as the role of children and the contribution of asymptomatic carriers to transmission. Finding answers to these questions is crucial to identifying targeted and sustainable control strategies to combat the spread of SARS-CoV-2 in Italy and around the world.

Professor Enrico Lavezzo, from the Department of Molecular Medicine at the University of Padua said: The result concerning asymptomatic carriers is key. We took a picture of the V population and found that about half of the population testing positive had no symptoms at the time of testing and some of them developed symptoms in the following days. This tells us that if we find a certain number of symptomatic people testing positive, we expect the same number of asymptomatic carriers that are much more difficult to identify and isolate.

The fact that the viral load is comparable between symptomatic and asymptomatic carriers means even asymptomatic infections have the potential to contribute to transmission, as some of the reconstructed chain of transmission obtained from the detailed contact tracing conducted in V confirmed.

On the one hand, it is likely that a symptomatic infection transmits large quantities of virus, for example via coughing, but it is also reasonable to think that symptoms may induce a person with a symptomatic infection to stay at home, limiting the number of contacts and hence the transmission potential. On the other hand, someone with an asymptomatic infection is entirely unconscious of carrying the virus and, according to their lifestyle and occupation, could meet a large number of people without modifying their behaviour.

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Whole-Town Study Reveals More Than 40% of Covid-19 Infections Had No Symptoms - Global Health News Wire

Age-of-onset information helps identify 76 genetic variants associated with allergic disease. – Physician’s Weekly

Risk factors that contribute to inter-individual differences in the age-of-onset of allergic diseases are poorly understood. The aim of this study was to identify genetic risk variants associated with the age at which symptoms of allergic disease first develop, considering information from asthma, hay fever and eczema. Self-reported age-of-onset information was available for 117,130 genotyped individuals of European ancestry from the UK Biobank study. For each individual, we identified the earliest age at which asthma, hay fever and/or eczema was first diagnosed and performed a genome-wide association study (GWAS) of this combined age-of-onset phenotype. We identified 50 variants with a significant independent association (P<310-8) with age-of-onset. Forty-five variants had comparable effects on the onset of the three individual diseases and 38 were also associated with allergic disease case-control status in an independent study (n = 222,484). We observed a strong negative genetic correlation between age-of-onset and case-control status of allergic disease (rg = -0.63, P = 4.510-61), indicating that cases with early disease onset have a greater burden of allergy risk alleles than those with late disease onset. Subsequently, a multivariate GWAS of age-of-onset and case-control status identified a further 26 associations that were missed by the univariate analyses of age-of-onset or case-control status only. Collectively, of the 76 variants identified, 18 represent novel associations for allergic disease. We identified 81 likely target genes of the 76 associated variants based on information from expression quantitative trait loci (eQTL) and non-synonymous variants, of which we highlight ADAM15, FOSL2, TRIM8, BMPR2, CD200R1, PRKCQ, NOD2, SMAD4, ABCA7 and UBE2L3. Our results support the notion that early and late onset allergic disease have partly distinct genetic architectures, potentially explaining known differences in pathophysiology between individuals.

PubMed

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Age-of-onset information helps identify 76 genetic variants associated with allergic disease. - Physician's Weekly

Wayne Medicine and Wayne Law professors team up to explore legal and ethical issues of wastewater monitoring for COVID-19 – The South End

Faculty from the Wayne State University School of Medicine and Wayne State University Law School have teamed to publish a paper this month on legal and ethical issues associated with community detection of COVID-19 through wastewatermonitoring.

Professor of Physiology Jeffrey Ram, Ph.D., and Associate Professor of Law Lance Gable, Ph.D., along with Dr. Rams daughter, University of Maryland Professor of Law Natalie Ram, co-wrote Legal and Ethical Implications of Wastewater SARS-CoV-2 Monitoring for COVID-19 Surveillance, now available in the Journal for Law and Biosciences.

The paper, already a popular download, is listed on the Social Science Research Networks Top Ten download list in several categories.

Dr. Ram also is director of the Wayne State University Belle Isle Aquarium Field Research Laboratory.

Scientists have observed that molecular markers for COVID-19 can be detected in wastewater during an outbreak and, in some cases, before the first case is confirmed, they wrote. The U.S. Centers for Disease Control and Prevention, and other government entities, are considering whether to add community surveillance through wastewater monitoring to assist in tracking disease prevalence and guiding public health responses to the pandemic.

This scientific breakthrough may lead to many useful potential applications for tracking disease, intensifying testing, initiating social distancing or quarantines, and even lifting restrictions once a cessation of infection is detected and confirmed. Yet, new technologies developed in response to a public health crisis may raise difficult legal and ethical questions about how such technologies may impact both the public health and civil liberties of the population, the authors wrote. Even if reliability and efficacy are established, limits on sample and data collection, use and sharing, must also be considered to prevent undermining privacy and autonomy in order to implement these public health strategies consistent with legal and ethical considerations.

The article describes recent scientific evidence regarding COVID-19 detection in wastewater, identifying public health benefits that may result from this breakthrough, and limitations of existing data. It also assesses the legal and ethical implications of implementing policy based on positive sewage signals.

The topic of wastewater epidemiology of COVID-19 is a very new and extremely active one, Dr. Ram said. We (at Wayne State) have assembled a team that includes microbiologists, an epidemiologist, a law professor, medical students, collaborators outside of Wayne State and more.We have support from Healthy Urban Waters.

Healthy Urban Waters is a collaboration of WSU researchers networked with the community to focus on water in an urban setting and future impacts of human culture on community, the ecosystem and economic health.

Dr. Ram and Dr. Gable were invited to present at a new community interaction forum organized with COVID-313 by the WSU Office of theProvosts Social and Behavioral Determinants of Health Steering Committee. They plan additional projects together.

Natalie Ram writes about the legal and ethical uses surrounding various biotechnologies, including the use of DNA by the police. Her decision to pursue the philosophical side of science, including ethics and law, was partly inspired by her Wayne State connections.She was part of a summer science program for girls organized by Wayne State Professor Alvin Saperstein at Wayne State, and while a college student at Princeton she conducted molecular research one summer on pre-implantation genetic diagnosis at WSUs Center for Molecular Medicine and Genetics.

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Wayne Medicine and Wayne Law professors team up to explore legal and ethical issues of wastewater monitoring for COVID-19 - The South End

Rare Disease Diagnostics Industry Anticipated to Reach $26.7 Billion by 2024 – Market Shares by Disease Class, Indication, Analysis Platform, Analysis…

DUBLIN, July 1, 2020 /PRNewswire/ -- The "Rare Disease Diagnostics: Technologies and Global Markets" report has been added to ResearchAndMarkets.com's offering.

The global rare disease diagnostics market should reach $26.7 billion by 2024 from $17 billion in 2019, rising at a CAGR of 9.5% over the forecast period.

The scope of the report includes rare disease diagnostic technologies, applications, industries, initiatives, patents and companies. The market for rare disease diagnostic products and services is given for 2018 and 2019, and then forecast through 2024.

This report reviews the main diagnostic technologies and explains why genetic variation is important in clinical testing and disease. It then discusses significant large-scale research initiatives that impact rare disease diagnostic applications. Of particular interest is a discussion of global population-scale sequencing projects and their likely impact in linking genetic variation to rare disease diagnostics. The main market driving forces for rare disease diagnostic products and services are listed and discussed.

The report categorizes and quantifies the rare disease diagnostics market by the disease category, technology platform, test purpose, analysis target and geography segments.

More than 95 companies in the rare disease diagnostic industry are profiled in this report.

The research also provides a summary of more than 50 of the main industry acquisitions and strategic alliances that took place from April 2018 through April 2020, including key alliance trends.

The report includes:

Market Insights

Rare diseases comprise a growing public health priority, as they affect upward of 300 million people globally and they are difficult to diagnose and treat.

There is a pressing need for better ways to detect and diagnose rare diseases, as well as to provide companion diagnostics for therapy guidance, clinical trials enrollment and therapy monitoring applications.

Better diagnostic tests for rare diseases can make significant differences in the lives of those affected by these conditions. Many rare diseases go undiagnosed for long periods of time because patients, families and physicians may have limited awareness of certain diseases, and the symptoms may not be informative to healthcare workers who may not have encountered such diseases before.

Extended time to diagnosis of a rare disease, along with so-called diagnostic odysseys, can lead to negative outcomes, including misdiagnosis or disease progression. Rapid, accurate diagnostics can significantly shorten these diagnostic odysseys.

In addition to early detection and diagnostic potential, rare disease therapeutics will be important in orphan drug development and use. Orphan drugs address rare disease patient populations, and they are expected to have a high growth rate through 2024. By 2024, orphan drugs may make up as much as one-fifth of global prescription sales. Rare disease diagnostics can be used to help physicians make proper decisions regarding which therapies to use and ways to monitor the efficacy of those therapies during treatment courses. Rare disease diagnostics can also be used to help select patients for orphan drug clinical trials.

More than 70% of rare diseases are inherited conditions, and they thus have genetic components, so this industry relies heavily on genetic analysis methods, including polymerase chain reaction (PCR), next-generation sequencing (NGS) and Sanger sequencing.

Key Topics Covered

Chapter 1 Introduction

Chapter 2 Summary and Highlights

Chapter 3 Overview

Chapter 4 Technology Background

Chapter 5 Rare Disease Diagnostics Initiatives

Chapter 6 Rare Disease Diagnostic Industries

Chapter 7 Rare Disease Diagnostics Strategic Alliances and Acquisitions

Chapter 8 Rare Disease Diagnostics Markets

Chapter 9 Rare Disease Diagnostics Patents and Intellectual Property

Chapter 10 Company Profiles

For more information about this report visit https://www.researchandmarkets.com/r/rp6ok6

Research and Markets also offers Custom Research services providing focused, comprehensive and tailored research.

Media Contact:

Research and Markets Laura Wood, Senior Manager [emailprotected]

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Rare Disease Diagnostics Industry Anticipated to Reach $26.7 Billion by 2024 - Market Shares by Disease Class, Indication, Analysis Platform, Analysis...

Why are some people at greater risk of severe COVID-19? – Medical News Today

A new study explores the interactions between airway cells and immune cells at the molecular level to identify why some people are at risk of severe COVID-19 while others are not.

There is plenty of evidence that SARS-CoV-2, the new coronavirus, affects individuals differently. About 80% of those who have SARS-CoV-2 experience a clinically mild version of COVID-19, meaning that they get better without needing to go to the hospital.

Risk factors for severe disease include being male, being older, and having underlying health conditions, among other factors.

What drives these risk factors is not entirely clear.

Some experts have suggested that an excessive immune reaction in response to the virus is at the heart of the damage to the lungs and other parts of the body that people with severe COVID-19 experience.

Writing in Nature Biotechnology, scientists from the Center for Digital Health at the Berlin Institute of Health (BIH) and the Charit Universittsmedizin Berlin in Germany aimed to tease out the molecular actions that underpin such excessive immune reactions.

Prof. Roland Eils, chair and founding director of the Center for Digital Health, is one of the five senior study authors.

To pinpoint how different cells interact and communicate with each other, the multidisciplinary research team performed a single cell RNA sequencing analysis of upper and lower respiratory tract samples from 19 people in the hospital with COVID-19 and five volunteers without the new coronavirus.

In total, the scientists analyzed 160,528 individual cells.

Of the 19 people with COVID-19, eight had moderate disease, the authors write, while they classed 11 as critical. Two people died from the disease.

In the participants with COVID-19, the team saw a three-fold increase in gene expression of the angiotensin converting enzyme 2 (ACE2) gene, which encodes the receptor that the new coronavirus uses to attach to cells during infection.

It is interesting to note that in the case of COVID-19, the signaling protein interferon, which is actually the immune systems central defense strategy against viral infections, contributes to the epithelial cells producing more ACE2 and hence becoming more vulnerable to viral infection, Prof. Irina Lehmann, head of the Molecular Epidemiology Research Group at the BIH and one of the studys senior authors, explains.

In COVID-19, the immune system thus helps the virus to infect further cells, thereby amplifying the disease, she continues.

Next, the team identified the specific subsets of epithelial and immune cells that were present in the samples and found proinflammatory cell types that may be driving cell death in the lungs.

Especially in severely ill patients, we observed that an overreactive immune system drives the destruction of the lung tissue. This might explain why these patients are more severely affected by the infection than patients in whom the immune system reacts appropriately.

Prof. Roland Eils, corresponding author

Professor Leif-Erik Sander, another of the study senior authors, also weighs in on the findings:

These results suggest that our treatments in COVID-19 patients should not only be directed against the virus itself but should also consider therapies that constrain the immune system, such as those now being used with dexamethasone, possibly even at the onset of the disease to prevent the immune system from overreacting.

Specifically, the researchers suggest that targeting the proinflammatory CCR1 and/or CCR5 pathways might suppress immune hyperactivation.

The team acknowledges that their study has some shortcomings. Due to the relatively low number of people with COVID-19 who required hospital care in Germany, the study was not large enough to look at the influences of age, sex, and underlying health conditions on the results.

The researchers were also not able to include people who had mild COVID-19 and did not require hospital care.

For live updates on the latest developments regarding the novel coronavirus and COVID-19, click here.

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Why are some people at greater risk of severe COVID-19? - Medical News Today

Experts warn of COVID-19 spread among people without symptoms – KSDK.com

While most people won't require hospitalization, it's hard to tell who will. That's why doctors recommend social distancing, even if you "feel fine."

ST. LOUIS With COVID-19 cases again on the rise in many places, health experts are once again warning of the danger that comes with asymptomatic spread: transmission of the virus from someone who isnt showing signs of infection.

That's been the Achilles heel really of this pandemic, said Dr. Jad Khoury, an infectious disease doctor at Mercy.

The CDC reports about 35% of infected people are asymptomatic, and the World Health Organization has determined about 40% of transmission may be from people who dont show signs of the virus. (The WHO has also walked-back their assessment of asymptomatic transmission as rare, after blow back and evidence from the global health community to the contrary.) Its hard for doctors to tell exactly how common this issince people who dont show symptoms usually dont get tested.

I think it's happening more so than we actually think, said Dr. Khoury.

Some experts worry asymptomatic carriers could pose the biggest public health risk in being able to get the virus under control.

The silent spread of the virus makes it all the more challenging to control, says Eric Topol, MD, professor of Molecular Medicine at Scripps Research. Their recent findings suggest asymptomatic carriers may have played a significant role in COVID-19s early spread.

As businesses reopen, even temperature checks at the door cant determine if someone contagious.

In a lot of cases fever may not be the initial or presenting symptom, said Dr. Khoury.

Sometimes a person is pre-symptomatic: they develop signs of the virus when theyve already had it for awhile.

Those are the patients that eventually developed symptoms, but they can transmit the virus before they start showing symptoms, said Dr. Khoury. And there's a debate about how soon before the symptoms show up can you transmit. Some accounts say like two to three days before you show symptoms, you can pass it on. Some say even up to six days prior to the symptom onset, that you can still have an infectious virus that you can pass on to others.

If you do show any symptoms, doctors warn: stay home. Even minor signs of the virus should be a major warning.

You're much more likely probably to get infected from somebody who is symptomatic than from somebody who is a symptomatic because they probably don't shed as much virus as a symptomatic person, he said, noting that coughs and sneezes carry more of the viral load than regular breathing does.

He adds, though, that when youre not wearing a mask or social distancing, youre also more likely to catch the virus from breathing and talking, even when no symptoms are present. The risk is definitely there.

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Experts warn of COVID-19 spread among people without symptoms - KSDK.com

Are Students Excited to Return to Campus This Fall? It Depends Who You Ask – Cornell University The Cornell Daily Sun

No forced triples. No crowded common rooms. No packed lecture halls.

President Martha E. Pollacks long-awaited Tuesday announcement welcomed Cornellians back to campus, but described a Cornell that faintly resembles the one students left in March. Many say they are still thrilled to return to Ithaca in September, eager to book plane tickets and arrange car rides as soon as move-in dates are announced.

But many students were also skeptical of the reopening message, wary of what social distancing will mean in an environment built for socializing. And for some students, the promise of a restricted in-person fall semester isnt compelling enough to return to Ithaca at all.

Lillian Hong 22 was excited when she first read the email. After months of waiting for fall semester news, her days at home in Boston finally became numbered.

I assumed we were going back, she said, but it was super great to finally get that information.

As Anneliese Markus 23 opened Pollacks email Tuesday afternoon, she too was relieved to hear that she would come back to New York after spending months at her childhood home in Colorado.

But Markus said the restrictions and regulations were hard to digest, learning she will return to take-out and reservation-only dining halls, online club meetings and likely few in-person classes.

Im so desperate to go back, Markus said. I just feel like Ive regressed as a human. I want to be back on campus, but theres so much that makes me sad. The whole point of school is to be a safe space, and so many people are losing that.

It wasnt worth it

Other students are less desperate to return. Jack Sillin 22 said he decided in May that this fall, he would plan to continue online learning at home in Yarmouth, Maine.

Living in an off-campus apartment wasnt worth the money while restricted to mostly online activities, Sillin said. Not wanting to risk thousands of dollars, he decided not to sign a lease for next year, figuring all classes would continue online in the fall.

Pollacks email only solidified his decision to stay home. Sillin said he realized the fall semester would exclude some of the experiences he values most: sharing meals with friends, in-person office hours and debating with the Cornell Political Union.

All those parts of the college experience are ones I value a lot, and they wont be possible to do responsibly until theres a vaccine, Sillin said. It wasnt worth it to me to spend about $12,000 on an apartment to be doing virtual office hours, virtual clubs, [and] many of my classes virtually.

Boris Tsang / Sun Photography Editor

Starbucks on March 20, after its dine-in operations were suspended. Students will return to a Collegetown this fall that will likely feel different from the placetheyleft in March.

Some students share Sillins reasoning: As the Cornell Reddit page swelled with comments about the fall reopening plan, one incoming sophomore wrote that if the classes Im taking are largely online I dont see the point of putting myself through so many restrictions and paying for dining and housing. Others expressed frustration over tuition, which appears unlikely to budge, whether or not they return to campus.

Another student wrote that with the slew of restrictions, they would rather stay at home even though the rising senior had previously marked on a survey that they would live in Ithaca if the semester were held online. Now, the student would happily change their response.

But factors beyond money and a seven-hour drive to Ithaca are pushing Sillin to remain home this fall. After mulling Pollacks email and reading the 97-page report, Sillin said he is skeptical students will change their behavior to comply with social distancing measures, even as administrators urge them to resist large gatherings.

The current reopening plan relies heavily on voluntary student compliance. According to Sillin, education campaigns and agreement signatures have an uninspiring track record, historically failing to prevent risky behavior such as underage alcohol use.

Why am I supposed to think that when we try those same tactics in this situation, all of a sudden were going to have compliance from everyone? Sillin said. It really only takes one frat party for all of these measures to be rendered moot. The bar is really high for changing behavior.

Sillin isnt the only student questioning whether their peers will radically adapt their behavior. Even the student-run McGraw Tower Instagram account @bingaleedingalee called on students currently partying in Ithaca to wear masks and respect social distancing, writing in a Tuesday post: Realize how your actions put cornell employees, immunocompromised folk, your peers at cornell who might not have the same access to masks that you might have, faculty, and families in ithaca, at risk!

Modeling the fall semester

Prof. Peter Fraziers model which became the basis for the Universitys reopening decision says a residential semester that includes a virus screening program will better protect the public health of the community than a semester held completely online.

But Jeff Pea grad, a Ph.D. student in cellular and molecular medicine who sat on a reopening committee, worries that Cornell placed too much weight on a model a predictive framework that relies heavily on assumptions to explain why they decided to welcome students back to campus.

He said the model attempts at [predicting] a lot of things well in trying to grasp what campus would look like in the fall. But with so much uncertainty, he said he doesnt fully agree with the conclusion that a residential semester is safer than keeping campus closed.

No model is perfect, Pea said. I think it shouldnt be what were putting all our weight into. Theres a real concern for students coming back.

Boris Tsang / Sun Photography Editor

The exodus of thousands of students in March left Cornells typically bustling campus nearly abandoned. With strict social distancing guidelines planned for the Universitys reopening, it remains to be seen what the new normal will look like.

Pea added that Pollacks reopening announcement was only a starting point for ongoing conversations about campus health and safety, with information gaps to fill, particularly within the graduate student community.

In a Sun letter to the editor, Pea, Rebecca Harrison 14 grad and Arielle Johnson grad called on Cornell to give all graduate students the option to workremotely without needing to go through medical accommodations or provide documentation. The current recommended policy asks graduate students to apply for remote work through Cornell Student Disability Services or their supervisor.

I share many other graduate students concerns about the absence of attention to our health and safety in President Pollacks reopening announcement, Harrison told The Sun in an email on Tuesday. Graduate student labor is critical for keeping the gears of undergraduate education at Cornell running, but this should not be at the expense of our own needs to be comfortable returning to our classrooms.

Nothing is clear

Pollacks email also left many undergraduates eager for more information. How will students physically distance while walking between classes? How will bathrooms operate? How will Cornell monitor travel away from campus?

For Markus, the reopening message left questions about everything from pre-enrollment dates to library policies.

Its all so obscure, whats going on behind the scenes, Markus said. Nothing is clear. I still dont really know what their plan is. I have no sense of what is going to go on next semester.

Even as the email left students with more questions than answers, many also said they see the value of reopening campus, particularly for those without access to a computer or a safe learning environment at home.

Sillin called reopening campus necessary for many students without quiet home study spaces and internet connection, even as he worries those who suffered the most during the remote spring 2020 semester could again face the brunt of a potential second campus shutdown.

Despite so many unknowns, students who are able to return know one thing: Theyre grateful to be heading back to campus, even if it wont feel the same.

Im absolutely just going to be glad to be back on campus, Hong said. Leaving was very emotional. It made a lot of us realize how much the college experience means to us, and its a short four years. Having any of that back in any capacity is better than nothing.

Hongs off-campus apartment lease has already started, but more than that, she said she is looking forward to building physical models with CUAir, her project team, and reuniting with her friends.

When she gets back to campus, she first plans to buy a tub of Big Red Bear Tracks.

Read more:

Are Students Excited to Return to Campus This Fall? It Depends Who You Ask - Cornell University The Cornell Daily Sun

How lab animals have fared in the coronavirus crisis – DW (English)

At a time when most of us had still not even thought about panic-buying toilet paper, Andreas Lengeling was stocking up on boxes of hay and aspen wood bedding, food pellets and veterinary drugs. He did not want to rely on external suppliers for the following three months. It was the end of February, and he was bracing himself for the coronavirus pandemic to hit Germany.

As the animal research and welfare officer at the Max Planck Society, Lengeling's main responsibility is to ensure that the 65 species of animals housed across its research institutes in Germany and abroad are well cared for. These include insects, rodents, fishes, clawed frogs, song birds and larger vertebrates like alpacas.

In March, US-based researchers gave accounts of how lockdowns and stay-in-place orders made it difficult to take care of lab animals. Thousands of mice have been culled. This is partly due to staff shortages as older and vulnerable people resort to working from home. Most experiments have also ground to a halt. A researcher in Colombia even carried 100 turtle eggs to her house to protect them.

Quick action and teamwork

"I'm absolutely concerned about these reports," says Lengeling. "It's really heartbreaking to hear."

Read more:Germany's CureVac to launch human trial of experimental coronavirus vaccine

Scientist and Animal Welfare Officer at Max Planck Society, Andreas Lengeling

But he reports that the situation has not been as dire in Germany.

"We reacted really early," says Lengeling. "At the end of February, we were already adapting our emergency plans to the pandemic scenario. We were really well-prepared."

Other institutes took early note as well. At the German Research Center for Environmental Health (HMGU) in Munich, where scientists work with rodents and fish, all new experiments were put on hold. Animals were, however, saved because of excellent cooperation between animal caretakers, scientists, animal welfare officers and the crisis management team, according to Johannes Beckers, an HMGU research group leader.

But not every institute in Germany acted in time to rescue test animals. The Max Delbrck Center for Molecular Medicine (MDC) in Berlin reported that 1,500 young mice and rats were euthanized as a consequence of the disruption caused by the pandemic. This is because most mice and rats used in experiments have to be at a specific age depending on what is being researched. These particular animals were too young to be used in experiments and will be too old by the time experiments resume.

Read more:Worldwide, researchers work on a coronavirus vaccine

Three zebrafish as imaged by Max Planck Institute for Developmental Biology in Tbingen

The MDC's press officer, Jutta Kramm, says that staff have, however, remained dedicated to maintaining the welfare of animals within their facility. "All suitable employees work in shifts to provide food and water to the animals and to clean the cages," she says.

The German Cancer Research Center has had to reduce the number of rodents in its care, too. But its response to DW's query on how many animals this might have involved is pending.

Experiments halted, projects delayed

The pandemic has posed a particularly difficult challenge to research labs that work with non-human primates such as rhesus macaques and marmosets. That is because there is a risk of humans transmitting a SARS-CoV-2 infection to monkeys in a so-called cross-infection.

This threat has had a large impact on researcher Sabine Borchert's life. As a technical assistant at the German Primate Center in Gttingen, Borchert typically spends several hours each day training macaque monkeys for experiments. She needs to learn what each monkey likes and dislikes eating, how each of them react to different situations and when changes in their behavior begin to signal stress. "When you walk into the department, you don't know what will happen that day," she says. "It's like having children."

But during the pandemic, scientists and assistants have split into mixed groups of two that work alternate weeks, minimizing contact among themselves and with the animals. This means Borchert sees far less of Ralph, Millhouse and Barney.

In the lab, led by Hansjrg Scherberger, monkeys learn to grasp objects of different shapes and sizes so that researchers can decode how the brain controls movements of the hands and fingers. Many monkeys have taken months and even years to learn these tasks. If they now spend an extensive period without practice, it is hard to say how long they will retain the abilities they have learned.

"I think they won't forget everything. But it will take weeks to get their performance back up again," says Borchert. This does mean, however, that doctoral and postdoctoral projects will be delayed by weeks or months.

Animals susceptible to SARS-CoV-2

Finding out which species of animals face the risk of getting infected by SARS-CoV-2 is, in its turn, the job of Andreas Lengeling in Munich. He digs through old literature on coronaviruses and sets up alerts on PubMed to track the release of new research papers. He shares his findings with veterinarians across the many Max Planck institutes to drive decisions.

Read more:Tiger tests positive for coronavirus at New York zoo

A rhesus macaque is learning to grasp objects of different shapes and sizes at German Primate Centre (DPZ) in Gttingen.

"Luckily, it looks like most of the animal species cannot be infected by the [new] coronavirus," says Lengeling. "But there are a few exceptions." Cats, hamsters, ferrets, minks and non-human primates can get sick. In macaque monkeys, the illness presents as mild, cold-like symptoms. Other animals, as of now, appear to be resistant to any natural transmission of SARS-CoV-2.

A recent study by Sinovac Biotech, a private Beijing-based company currently racing to develop the first coronavirus vaccine, showed that its vaccinecontaining an inactivated form of the virusmakes macaque monkeys immune to a second infection. But this finding must be taken with a pinch of salt: As symptoms of COVID-19 in humans are far more damaging and severe, the animal and human systems are not necessarily comparable.

Animal testing for COVID-19

These tests of COVID-19 vaccines on animals and the news that many lab rats have been culled has fueled an old and ongoing debate. Those who do not support animal testing to gain scientific knowledge and say the cruelty it entails outweighs its benefits have initiated online petitions and started threads on Reddit.

But Ulrich Kalinke, a professor at the Institute for Experimental Infection Research in Hanover, makes a clear case for continuing animal testing. He says that developing a vaccine without an infection model is not only dangerous, but difficult.

"I feel tremendous pressure," says Kalinke. "We need a vaccine. But if you try to address those questions only in humans, without putting humans in danger, you would have to start with very, very low dosages of vaccine. This would take ages."

And time is of the essence in this fight against the novel coronavirus.

Vaccines: Sometimes a two-edged sword

In the past, there has been no dearth of examples where the use of new vaccines has gone wrong. In 1966, a clinical trial of a vaccine against respiratory syncytial virus in the US met a disastrous end when it resulted in the death of two infants. More recently, an oral vaccine for polio, given widely to low and middle-income families across the world, was discovered to have caused many cases of the disease instead.

Read more:What is the future of animal testing?

Scientist and professor Ulrich Kalinke from Institute for Experimental Infection Research in Hannover is heading project TWINCORE for coronavirus-related research

Ulrich Kalinkesays that the scientific community has learned from such failures. He also wants to avoid a scenario where one individual out of every 1,000 vaccinated comes down with severe side effects, when prior testing in animals can prevent this from happening.

In the project TWINCORE, he is leading the development of a mouse model of COVID-19 that will show the same pathology of the disease as seen in humans. The idea is to then inject vaccines and test what kind of immunity is created throughout the bodies of mice.

Ulrich Kalinke said the mass inoculation needed to curb the coronavirus pandemic across the globe means that safety concerns are paramount: "We are speculating that there will be the need to vaccinate maybe one or two-thirds of the whole world population. So we had better know that the vaccine is safe."

Researchers at the Harbin Veterinary Research Institute in China have found that the novel coronavirus, also known as COVID-19, can be transmitted between cats. Domesticated house cats are also able to pass the virus on to members of their species, but not very easily, said Hualan Chen, a lead researcher of the - not peer reviewed -paper which was published in "bioRxiv" on March 31.

But cat owners shouldn't panic. Felines quickly form antibodies to the virus, so they aren't contagious for very long. Domestic cat owners with preexisting medical conditions, or the elderly, should temporarily restrict where their cats are able to wander. Healthy people should wash their hands thoroughly after patting them.

Unlike cats, the virus is unable to replicate easily in dogs, the researchers report. So you're all clear when it comes to walking or training your pooch.

This domesticated pig out walking the streets of Rome doesn't need to be afraid of any dogs. And, the dog needn't be afraid of its grunting opponent, either. Pigs aren't considered a natural reservoir for the coronavirus, the veterinarians discovered.

Things are different for the members of the Mustelidae family. Hualan Chen also researched ferrets, and found that SARS-CoV-2 is able to reproduce in these animals, just as in cats. The transmission between the animals occurs through respiratory droplets. Researchers found the virus on swabs taken from the throat and nose of ferrets and cats, but were unable to detect any lung infections.

Experts have given the all-clear for people who handle poultry, such as this trader in Wuhan, China, where scientists believe the first case of the virus emerged late last year. Humans have nothing to worry about, as chickens are practically immune to the SARS-CoV-2 virus, as are ducks and other bird species.

People can be infected by animals, but the same can also happen in reverse. Four-year-old Malayan tiger Nadia tested positive for COVID-19 recently at the Bronx Zoo in New York. "It's the first time, to our knowledge, that a [wild] animal has gotten sick from COVID-19 from a person," Paul Calle, the zoo's chief veterinarian, told "National Geographic" magazine.

Bats are considered the most-likely carrier of SARS-CoV-2, but veterinarians believe that in December 2019, another species must have existed in Wuhan as an intermediate host between them and humans. Could it have been ferrets or cats?

Pangolins are also under suspicion for transmitting the virus. Researchers from Hong Kong, China and Australia have detected a virus in a Malaysian Pangolin that shows stunning similarities to SARS-CoV-2.

Author: Fabian Schmidt

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How lab animals have fared in the coronavirus crisis - DW (English)

Hope against COVID-19: Drug cuts deaths by a third and other findings – Medical News Today

Given the current climate primarily in the United States of social unrest, injustice, and uncertainty, it may seem strange to read or even think about hopeful or positive things. But scientists are advancing in the fight against the new coronavirus, and this feature rounds up their progress.

Some have suggested that the U.S. is currently struggling with two pandemics at once. Although a simple vaccine cannot fix the racism pandemic, many scientists are actively working to tackle the ongoing COVID-19 crisis in their labs.

In this feature, we continue our series on hopeful scientific findings by rounding up the evidence available. Since we last wrote about scientific progress in the fight against COVID-19, many developments have taken place.

A mathematical model showed that the widespread use of face masks even homemade ones could slow the pandemic and prevent a second wave. Meanwhile, a new antibody test promises more accuracy, and a study has shown that the lockdown measures that authorities put in place prevented an additional 500 million infections a staggering number.

Importantly, an analysis of more than 15,000 new coronavirus genomes from 75 different countries revealed that SARS-CoV-2 mutations do not strengthen the virus but are either neutral or detrimental to it.

The most heartening findings, though, are probably in the realm of potential treatments. From a duo of antiviral drugs that inhibits the virus to a common steroid drug that slashed deaths in a clinical trial and a cancer drug that may prevent severe inflammation, we explore potential new therapies for COVID-19 below.

First, we begin with the surprising benefits that an antibiotic may offer in the treatment of COVID-19.

Article summary

Medical News Today has recently conducted an exclusive interview with Dr. Catherine Oldenburg, co-principal investigator in the ACTION trial.

The ACTION trial is a nationwide trial in the U.S. that is designed to evaluate the efficacy of a single dose of azithromycin compared to placebo for [the] prevention of hospitalization in COVID-19 patients who have either no symptoms at all or mild-to-moderate ones.

In the interview, Dr. Oldenburg explains why she and her team chose azithromycin, an antibiotic, to treat an infection with SARS-CoV-2.

The researcher notes that the choice of an antibiotic to treat a viral infection may seem counterintuitive, as antibiotics do not treat viruses. However, azithromycin is special in that it affects the immune system.

[O]ne of the interesting things about azithromycin is that it has really strong immunomodulatory effects, so it has these [] nondirect effects on the immune system. That means its an interesting candidate.

Previous studies have shown the drug to be effective against SARS-CoV-2 when in combination with hydroxychloroquine. However, because the latter raised great concerns about safety, and the FDA have retracted their emergency use authorization for it, the scientists decided to investigate the antibiotic on its own.

Furthermore, due to its excellent safety profile and extremely wide use, Dr. Oldenburg explains, azithromycin was perfect for including in an outpatient trial. The interview contains details about how to enroll in the trial.

A team of researchers from the United Kingdom recently announced that the common steroid drug dexamethasone drastically reduced deaths in a clinical trial of people with severe COVID-19.

Scientists at the University of Oxford led the trial, called RECOVERY, which involved testing six potential treatments for COVID-19, dexamethasone being one of them. Doctors commonly use dexamethasone to treat inflammation, allergic reactions, and immune-mediated conditions.

In the trial, the researchers compared dexamethasone treatment with standard of care in a group of severely ill COVID-19 patients who required ventilators or supplemental oxygen to breathe.

The 28-day mortality rate was one-third lower in the dexamethasone group.

Furthermore, the overall mortality rate was 17% lower in the dexamethasone group than in the control group.

Commenting on the findings, Duncan Young, a professor of intensive care medicine at the University of Oxford, said:

The results are very robust due to the large number of patients recruited to the trial. The drug prevented one death in eight in ventilated patients, and one death in 25 in patients on oxygen.

Although this appears [to be] a relatively modest effect on outcome, for ventilated patients, the NNT (number needed to treat) of eight is better than almost any other intervention studied in patients on ventilators for any disease.

Dr. Nick Cammack, COVID-19 Therapeutics Accelerator Lead at the Wellcome Trust in London, said:

This is a major breakthrough: Dexamethasone is the first and only drug that has made a significant difference to patient mortality for COVID-19. Potentially preventing one death in every eight ventilated patients would be remarkable. Finding effective treatments like this will transform the impact of the COVID-19 pandemic on lives and economies across the world.

While this study suggests dexamethasone only benefits severe cases, countless lives will be saved globally, added Dr. Cammack.

Drugs such as dexamethasone have an advantage over novel treatments in the fight against COVID-19 due to their proven safety record. After a clinical trial, they can be fast-tracked to reach the wider population.

So, other scientists have looked to similarly safe and already approved drugs for help in the fight against the virus.

After testing several antiviral drugs in a cell culture model, scientists in Norway and Estonia found that a combination of nelfinavir, an anti-HIV drug, and amodiaquine, an antimalarial drug, inhibited SARS-CoV-2 in the lab.

One of the drugs worked by shielding the healthy host cells, while the other targeted the virus itself. Scientists say that this combined strategy has worked well in the past against infections with other viruses.

Now, the scientists are looking to move to preclinical and clinical studies.

The same team of Estonian- and Norwegian-based researchers set out to test the efficacy of convalescent blood plasma for treating COVID-19, after concerns emerged that the approach may not be as effective as the team initially believed.

The scientists found that the blood of patients who had recovered from COVID-19 more recently contained more antibodies. Therefore, their serum was better at neutralizing the virus than the serum that the researchers collected from people later after their recovery.

This means if you collect blood from patients who have recovered from COVID-19 after 2 months from diagnosis of the disease and transfuse their plasma/serum to severely sick patients, it may not help, says study co-author Svein Arne Nordb, an associate professor in the Norwegian University of Science and Technologys Department of Clinical and Molecular Medicine.

The conclusion so far is that clinicians need to collect plasma for treatment purposes as soon as patients recover from COVID-19.

Svein Arne Nordb

In the meantime, another preliminary study has confirmed the safety of convalescent plasma, further adding to the evidence that the practice is indeed safe. The MNT article that covers the study also tackles some concerns about how to time the use of plasma as therapy.

Giving the therapy earlier in the illness would be safer and more effective for the patient, as after a certain point, their immune system is likely to go into inflammation overdrive, triggering a phenomenon known as a cytokine storm.

Concerns about the cytokine storm drove the efforts of another team of researchers, who used a cancer drug to quench inflammation in people severely ill with COVID-19.

During the cytokine storm, the hyperinflammation that causes damage to the lungs and other vital organs may result in death for these individuals.

Macrophages are a type of immune cell that plays a role in triggering the cytokine storm. More specifically, an enzyme called Bruton tyrosine kinase (BTK) initiates this phenomenon.

Scientists at the National Cancer Institute, U.S., turned to an already existing cancer drug that inhibits the activity of BTK in the hope that it will prevent the cytokine storm in COVID-19.

The drug is called acalabrutinib, and doctors currently use it to treat blood cancers. In the new study, the team administered acalabrutinib for 1014 days to 19 people hospitalized with COVID-19. At the start of the study, 11 participants needed oxygen masks to breathe, and eight were on ventilators.

By the end of the 14 days, eight of the 11 patients who had been using oxygen masks no longer needed help breathing and were discharged from the hospital.

Of the eight patients on ventilators, four no longer needed them, and two were discharged from the hospital. The other two patients had died. Importantly, the drug showed no evidence of toxicity.

Research from 2016 showed that a type of UV light that has shorter wavelengths called UVC light can kill coronaviruses on surfaces.

In a new study appearing in the journal The Lancet Microbe, an international team of researchers introduced a new material that conducts electricity and is transparent to UV light. The material could serve to make portable devices that can kill SARS-CoV-2 on surfaces, thus disinfecting them, say the researchers.

The authors explain that they believe that manufacturers could incorporate UV LEDs made with their new material into lamps that are lighter, cheaper, and more efficient than the standard disinfecting lamps that are already available.

For live updates on the latest developments regarding the novel coronavirus and COVID-19, click here.

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Hope against COVID-19: Drug cuts deaths by a third and other findings - Medical News Today

Researchers find on-off switch for inflammation related to overeating – ScienceBlog.com

Researchers at Yale have identified a molecule that plays a key role in the bodys inflammatory response to overeating, which can lead to obesity, diabetes, and other metabolic diseases. The finding suggests that the molecule could be a promising therapeutic target to control this inflammation and keep metabolic diseases in check.

The study appears on June 29 in theProceedings of the National Academy of Sciences.

When a person overeats, the body stores excess calories in the form of fat in the adipose tissue, or body fat, said lead authorXiaoyong Yangof Yale School of Medicine. As the amount of calories consumed continues to increase, this leads to inflammation in adipose tissue and the release of fatty acids into other tissues, including the liver and muscles.

This is dangerous, Yang said, and leads to metabolic disorders like diabetes.

Researchers were aware that overeating led to inflammation and metabolic diseases, but until now, they did not know the precise way that the bodys immune cells, such as macrophages which react to excess calorie consumption contributed to this process. The new research by Yang and team zeroed in on a pathway called O-GIcNAc signaling, which activates when a person overeats, instructing the cells to limit inflammation.

Inflammation happens when the bodys immune system reacts to injury or threat, and involves increased blood flow, capillary dilation, and an influx of white blood cells.

The body is smart, said Yang, associate professor of comparative medicine and of cellular & molecular physiology. It tries to protect against inflammation when fat builds up in the body. We discovered a key pathway that quenches inflammation caused by overnutrition.

In particular, the researchers found that OGT (O-GIcNAc transferase), an enzyme that activates GIcNAc signaling, was responsible for activating the bodys pro-inflammatory response by turning on or off a specific signaling pathway in macrophages.

The macrophage can be a good guy or a bad guy, Yang said. It becomes a bad guy in overnutrition, secreting a lot of inflammatory factors. In other contexts, its a good guy and has an anti-inflammatory effect. We found out that OGT tries to stop the macrophage from becoming a bad guy to stop the pro-inflammatory response.

Their finding suggests that OGT could be a target for new therapies to suppress inflammation and improve health.

The study also sheds light on the workings of glutamine and glucosamine, nutritional supplements recommended by doctors for arthritis and inflammation of the joints, Yang said. While researchers have known that these supplements promote O-GlcNAc signaling and reduce inflammation, they did not know how this process worked.

Our finding further implicates how glutamine and glucosamine suppress inflammation, Yang said.

Other members of the Yale research team include Dr. Gerald I. Shulman, Dr. Marie E. Robert, Rachel J. Perry, Yunfan Yang, Xiruo Li, Harding H. Luan, Bichen Zhang, Kaisi Zhang, Zongyu Li, Minnie Fu, Dongyan Zhang, Simeng Wang, Yuyang Liu, Joo Paulo Albuquerque, Qunxiang Ong, Rui Li, and Qi Wang.

Original post:

Researchers find on-off switch for inflammation related to overeating - ScienceBlog.com

Global Nuclear Medicine Market By Therapy, By Type, By Application, By Therapeutics, By Route of Administration, By End-User, By Region, Forecast…

NEW YORK, July 1, 2020 /PRNewswire/ -- This report is 80% complete and can be delivered within three working days post order confirmation and will include the latest impact analysis of Covid-19 in 2020 and forecast.

Read the full report: https://www.reportlinker.com/p05916726/?utm_source=PRN

Global Nuclear Medicine Market By Therapy (Radioactive Iodine, Radioactive Antibodies, Others), By Type (SPECT, PET, Alpha-emitters, Beta-emitters, Brachytherapy), By Application (Cardiology, Respiratory, Orthopaedics, Others), By Therapeutics (Alpha Particle Emitters, Beta Particle Emitters, Others), By Route of Administration (Oral, Intravenous, Nasal), By End-User (Hospitals, Diagnostic centers, Others), By Region, Forecast & Opportunities, 2025

Global nuclear medicine market is estimated to grow at an impressive rate during the forecast period owing to increasing incidence and prevalence of diseases like cancer, initiatives to reduce the demand and supply gap of Mo-99 and increasing research and development activities in radiotherapy to treat various diseases. Furthermore, nuclear medicines are extensively being used in molecular imaging, which is a technique involving molecules as biomarkers for specific molecular processes that determines the onset or progress of a disease. Nuclear medicines are convenient and safer alternative for patients as compared to X-Rays and other external radiation imaging devices.Due to this major factor, chemotherapy methods are being replaced by radiopharmaceuticals or nuclear medicines for cancer treatment.

They are also used in applications such as lymphoma and bone metastasis.Some of the nuclear medicines used in diagnostic procedures are F-18, Tc-99, Ga-67, and I-123 while I-131, Ir-192, Y-90, I-125, Lu-177, and Ra-223 are used in therapeutics procedures.

These factors are anticipated to drive global nuclear medicine market until 2025.

Apart from above mentioned growth factors, the global nuclear medicine market also faces some restrains.Short half-life of nuclear medicines or radiopharmaceuticals reduces their potential adoption.

Other restraining factors include supply shortages, logistical difficulties, and limited number of trained medical personnel.

The global nuclear medicine market is segmented based on therapy, type, application, therapeutics, route of administration, end-user and region.Based on application, the global nuclear medicine market is segmented into cardiology, respiratory, orthopaedics, neurology, oncology and urology.

Among them, the oncology segment accounts for the major market share due to increasing prevalence of cancer worldwide.Based on type, the nuclear medicine market is segmented into SPECT, PET, alpha-emitters, beta-emitters and brachytherapy.

The SPECT segment accounts for the largest market share and is expected to hold its dominance in the coming years owing to low cost and wide usage in different applications.

Major players operating in the global nuclear medicine market include Cardinal Health, Curium, Lantheus, Bracco, Advanced Accelerator Applications, NTP Radioisotopes, Eckert & Ziegler, Jubilant DraxImage, GE Healthcare, Siemens Healthineers, Rotem Industries, Eczacibasi-Monrol, IBA Group, Ire-Elit, Lucerno Dynamics, Positron Corporation, NorthStar Medical Radioisotopes, Pharmalucence, Norgine, Roche and others. Key market players are implementing activities like product developments, business expansion, and collaborative development to maintain significant share in the market for nuclear medicine.

Years considered for this report:

Historical Years: 2015-2018 Base Year: 2019 Estimated Year: 2020 Forecast Period: 20212025

Objective of the Study:

To analyze and forecast the market size of global nuclear medicine market. To classify and forecast global nuclear medicine market based on therapy, type, application, therapeutics, route of administration, end-user, company and regional distribution. To identify drivers and challenges for global nuclear medicine market. To examine competitive developments such as expansions, new product launches, mergers & acquisitions, etc., in global nuclear medicine market. To conduct pricing analysis for global nuclear medicine market. To identify and analyze the profile of leading players operating in global nuclear medicine market. The analyst performed both primary as well as exhaustive secondary research for this study.Initially, the analyst sourced a list of manufacturers across the globe.

Subsequently, the analyst conducted primary research surveys with the identified companies.While interviewing, the respondents were also enquired about their competitors.

Through this technique, the analyst could include the manufacturers which could not be identified due to the limitations of secondary research. The analyst examined the manufacturers, distribution channels and presence of all major players across the globe. The analyst calculated the market size of global nuclear medicine market using a bottom-up approach, wherein data for various end-user segments was recorded and forecast for the future years. The analyst sourced these values from the industry experts and company representatives and externally validated through analyzing historical data of these product types and applications for getting an appropriate, overall market size.

Various secondary sources such as company websites, news articles, press releases, company annual reports, investor presentations and financial reports were also studied by the analyst.

Key Target Audience:

Nuclear medicine manufacturer, suppliers, distributors and other stakeholders Hospitals & Clinics Government bodies such as regulating authorities and policy makers Organizations, forums and alliances related to nuclear medicine Market research and consulting firms The study is useful in providing answers to several critical questions that are important for the industry stakeholders such as manufacturers, suppliers and partners, end users, etc., besides allowing them in strategizing investments and capitalizing on market opportunities.

Report Scope:

In this report, global nuclear medicine market has been segmented into following categories, in addition to the industry trends which have also been detailed below: Market, By Therapy: o Radioactive Iodine o Radioactive Antibodies o Radioactive Phosphorus o Others Market, By Type: o SPECT (Single Photo Emission Computed Tomography) o PET (Positron Emission Tomography) o Alpha-emitters o Beta-emitters o Brachytherapy Market, By Application: o Cardiology o Respiratory o Orthopaedics o Neurology o Oncology o Urology Market, By Therapeutics: o Alpha Particle Emitters o Beta Particle Emitters o Auger Electron Emitters Market, By Route of Administration: o Oral o Intravenous o Nasal Market, By End-User: o Hospitals o Diagnostic Centers o Others Market, By Region: o Asia-Pacific o Europe o North America o South America o Middle East & Africa

Competitive Landscape

Company Profiles: Detailed analysis of the major companies present in global nuclear medicine market.

Available Customizations:

With the given market data, we offers customizations according to a company's specific needs. The following customization options are available for the report:

Company Information

Detailed analysis and profiling of additional market players (up to five).

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About Reportlinker ReportLinker is an award-winning market research solution. Reportlinker finds and organizes the latest industry data so you get all the market research you need - instantly, in one place.

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Tati Westbrook claims Shane Dawson offered to edit her 2019 video that set off a YouTube beauty war – Insider – INSIDER

In a bombshell video, YouTube beauty guru Tati Westbrook countered Shane Dawson's recent claim that he had no part in planning or orchestrating her 2019 expos about James Charles titled "Bye Sister." According to Westbrook, Dawson "used, coerced, and manipulated" her into filming the infamous video with the help of polarizing makeup mogul Jeffree Star. Dawson, Westbrook added, personally offered to help her edit and title the video, in which Westbrook alleged that Charles, a superstar in the world of beauty influencers, was a bad friend who'd repeatedly engaged in inappropriate behavior with straight men.

"He even offered to design the thumbnail and help title it," Westbrook said in the June 30 upload. "I declined his offer, but his gesture reinforced and supported for me that he was telling the truth. Why else would he jeopardize his career? So surely Jeffree was telling the truth, too. Keep in mind that up until this point, I didn't even know I was making a video. So how is it that so many editorial outlets knew that something was coming before I had even made a decision to film?"

The release of "Bye Sister" in May 2019 is widely considered to be a tipping point in the multi-part community-wide flame war known as "Dramageddon" and "Dramageddon 2.0." After the release of "Bye Sister," Star chimed in with unsubstantiated allegations of his own and called Charles a "predator" and a "danger to society." Charles denied these claims in a response video titled "No More Lies."

Nevertheless, lines were drawn between friends and rivals, and across social media, many creators and fans chose sides: that of Charles, or that of Westbrook and Star. Since 2018, Dawson and Star have benefitted from a lucrative joint rebrand that has spawned many successful collaborations, including a docuseries and a best-selling, conspiracy-themed makeup collection. Recently, Dawson published a lengthy statement in which he admitted to knowing Westbrook was "thinking about making a video" but denied having any idea how "intense" it would be. Dawson also denied playing any role in planning or orchestrating the expos.

"I struggled with the decision to film my video for days," Westbrook continued in her latest video.

Westbrook called her decision to film "Bye Sister" one of the biggest regrets of her life, and since then, she had made private and public amends with Charles. But at the time, Westbrook said she was vulnerable to the alleged manipulati0n of Star, Dawson, and "others" because she was upset with Charles for doing sponsored content for Sugar Bear Hair Care, a competitor of Westbrook's Halo Beauty vitamin brand. Star, Westbrook said, was obsessed with talking about Charles' supposed indiscretions.

"Over the course of the next few weeks, he [Dawson] and Jeffree fed me so much information that I felt sick. Almost every day there was more information and new allegations," Westbrook said. "Eventually I believed what they were saying because they said they had evidence. By the time the drama around James Charles' promotion of Sugar Bear Hair reached its peak, I was beyond gaslit."

On Tuesday, Dawson live-streamed his reaction to Westbrook's video on Instagram, in addition to calling her version of events a "f---ing lie" on Twitter.

"You are so manipulative," Dawson said while watching Westbrook get emotional on camera. "You're fake crying. You are fake crying, that is not real. Oh my god."

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Tati Westbrook claims Shane Dawson offered to edit her 2019 video that set off a YouTube beauty war - Insider - INSIDER

CamScanner banned in India: 5 alternative apps you can use – The Indian Express

By: Tech Desk | New Delhi | Updated: June 30, 2020 7:26:58 pm CamScanner is now banned in India.

CamScanner is a nice app to scan documents but it got banned in India along with other 58 apps from Chinese companies following the governments order. One of the popular apps on this list, TikTok, has been taken down from the Google Play and Apple App Store but CamScanner is still available at these stores. However, it could also follow suit considering it is now banned in the country.

If you are a user of the application, you will probably need a replacement. We have curated a list of CamScanner alternatives based on their efficiency and positive reviews they received on the app stores.

Adobe Scan comes to the mind first when you think about CamScanner alternatives. As the name suggests, the app is developed by Adobe and comes with loads of features, which is expected from a document management conglomerate like Adobe.

Developed Microsoft, the Microsoft Office Lens is another powerful CamScanner alternative. The application lets you scan all kinds of documents and export them to word or powerpoint directly. The app works even better for those who are already into Microsofts ecosystem.

The PhotoScan is developed by Google that not only lets you scan documents but comes quite handy if you want to scan printed photos and save them as digital copies. The PhotoScan is pretty good at creating digital photos from physical ones and does cropping work on its own.

Also read | Explained: How will the ban of TikTok and other Chinese apps be enforced; what will be the impact?

TapScanner is also a good alternative to the CamScanner app. The unique thing about this app is that it takes multiple photos to create a detailed scanned document. You can export the scanned copies in a number of formats and upload them to the cloud as well.

TurboScan lets you do almost all the work CamScanner is capable of. The application features auto edge detection, multiple scanning, and more features along with a sharpening mode that created better scanned copies.

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CamScanner banned in India: 5 alternative apps you can use - The Indian Express

Innovative device to remotely monitor student-athletes amid the pandemic – University of Miami

With student-athletes returning to campus, the University is adding tele-vigilance to its multifaceted approach for containing the coronavirus.

As the father of a young daughter with frequent ear infections, Dedi Gilad spent too many hours in a clinic waiting to see the childs doctor, fretting about their time away from school and work, and dreaming of a better way to diagnose and treat common ailments.

Now the little device that Gilad, the co-founder of Tyto Care, developed to provide on-demand medical exams is poised to deliver on a big promise to University of Miami student-athletes who are returning to campus amid the pandemic. Should they exhibit even minor symptoms of the highly contagious coronavirus that shut down South Florida in mid-March, or come in contact with anyone who has tested positive, theyll have almost instant access to a doctor who can examine and monitor them very closelybut from afarwith one of Tyto Cares TytoHome kits.

Thanks to the generosity of two donors and the vision of Dr. Roy E. Weiss, the chair of the Miller School of Medicines Department of Medicine, 300 of the palm-sized instruments are in the hands of the Athletics Department, which is test-piloting the instruments use for the University at large. They will enable UHealth providers to remotely peer down a patients throat, inspect their eardrums, listen to their lungs and heart, take their temperature, and even measure the oxygen levels in their blood.

We have long been proponents of investing in, developing, and using new tools for telehealth, said President Julio Frenk. The COVID-19 pandemic has only accelerated innovation in this space and Dedi Gilads Tyto Care home kits add enormous valuegiving us the ability to follow up with members of the University community who are in isolation after testing positive or having been exposed to the virus.

Blake James, director of athletics, said the Universitys nearly 400 student-athletes and 200 trainers and other department staff members are an ideal control group for testing the telehealth devices for all students, faculty, and staff returning in the fall.

From a lay persons view, I see this awesome technology as the way medicine is going in the future, and Im excited that we get to incorporate it into our plan for our kids right now, James said. Its a great opportunity for us to be able to give our athletes and their families greater peace of mind while giving our medical experts a real-life test of how it will work and what the challenges may be.

Providing peace of mind from three different perspectivesthe students, their families, and UHealth caregiversis what Weiss had in mind when he suggested the University become the first to integrate Tytos into its multifaceted plan for the resumption of on-campus classes. As he noted, students and their parents need to know that expert medical care is readily and continuously available if needed. And, caregivers need to know that those who arent sick enough for hospitalization arent deteriorating in isolation or infecting others when they are monitored.

Universities across the nation are focused on the three Tstesting, tracking, and tracingwhich we all must do to safely return students to our campuses, Weiss said. But were adding what I call the fourth Ttele-vigilance, which will allow us to make sure our student body is healthy and stays healthy.

For now, Tyto devices, named for the genus of barn owls that, like most owls, have spectacular long-distance vision, will be issued on an as-needed basis to student-athletes, athletics staffers, or others involved in their activities who meet one of four conditions, but dont need hospitalization. The conditions are those who test positive for COVID-19; develop a sore throat, fever, or other symptoms suggestive of the virus; have diabetes, asthma, or other underlying medical conditions that put them at significant risk for the disease; or have been exposed to individuals who have tested positive, as well as those who need to be monitored or quarantined because of their travels.

Student-athletes and staff who receive the devices will be quarantined and trained to perform their own daily health exams and upload the digital results via Tytos app to their UHealth electronic medical record, which will be reviewed daily by their team doctor or other health professionals. Alternatively, health care providers can connect to the isolated patients virtually and conduct the exam themselves, seeing the results in real time.

Its an extremely disruptive technology. I wish I had thought of it, said Luis Feigenbaum, the Universitys senior associate athletics director for performance, health and wellness. The typical workflow of checking up on our athletes or staff would require them to come to campus. So, if we can mitigate the risk to them and to others by limiting the amount of time outside of quarantine and isolation, that would be a tremendous win for everyone.

Originally developed and marketed in Israel by Gilad and Tyto Care co-founder Ofer Tzadik to deliver on-demand medical exams and diagnoses to families anywhere and anytime, the FDA-cleared devices entered the U.S. market in 2017. Two years later, TIME magazine included TytoHomes on its annual list of the worlds best inventions. Then in February, when Israels Sheba Medical Center was searching for a safe way for its staff to monitor a dozen Israelis who were returned to their homeland from the virus-stricken cruise ship Diamond Princess, Tyto Care found a vital, new calling.

Tyto Care provided the easy-to-use home kits that enabled the isolated passengers to share their daily health status with Sheba physicians, ensuring that none of the infected passengers took a turn for the worse or spread the disease while they improved. Now, most of Israels hospitals rely on Tyto devices to remotely examine quarantined patients in hospitals and isolated patients at home.

As a dad of two, I can relate to all of the struggles parents face when it comes to their kids' health, especially in the wake of COVID-19, said Gilad.As the world grapples with how to re-open safely, giving peopleespecially students returning to college campusesunprecedented access to medical care is of utmost importance in mitigating the spread.

But long before anyone heard of the novel coronavirus that originated in China at the end of 2019, Israelis largest health system began introducing TytoHome kits to families with children who, like Galids daughter, suffered from chronic earaches or other common acute ailments. Clalits incentive was a 2016 clinical study that showed Tyto Cares easy-to-use devices minimized emergency room and clinic visits, improved access to care, and eased reservations about using telehealth.

And that change in attitude, Weiss said, is already emerging as one of the pandemics few silver linings.

The world is changing and medicine B.C.before COVIDand medicine P.C.post COVIDwill never be the same, Weiss said. The ease of being able to see your doctor with telemedicine is here to stay. Theres no question about that. Patients and doctors are accepting this movement, and COVID is the enzyme that catalyzed it. That will be one of the positives of our experience with COVIDto embrace and enhance telemedicine.

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Innovative device to remotely monitor student-athletes amid the pandemic - University of Miami

How to get started with TikTok – The Verge

TikTok has gone viral and then some. A spiritual successor to Vine and an actual successor to Musical.ly, the shortform video sharing app has swept the world in the past year. Like other social media apps, its frequently the source of viral memes, slang, challenges, and dances. You may have seen it on the news when teenagers used the app to spread the word about a plan to reserve tickets for a Trump rally (and then not show up), when lawmakers called for a national security review of the app, or when it launched last years runaway hit song, Lil Nas Xs Old Town Road. Initially popular mostly among teenagers and young adults, since the start of the coronavirus pandemic, TikTok has exploded in popularity among users of all ages.

TikTok serves an endless scroll of videos on your For You page. You can scroll down to keep watching videos that TikTok has curated for you based on your likes and activity using its algorithm. (This is not necessarily a good thing. TikTok has been suspected of suppressing black creators and had been preventing users from getting their content on For You based on their appearance and whether they appeared to be in slums or dilapidated housing. In the past, it has also suppressed videos by LBGTQ creators and creators with disabilities.) You can also find content and creators to follow by searching up hashtags and even sounds.

If you want to post your own content, you can edit your videos in-app. Videos recorded through the app can be a maximum of 15 seconds long, but you can string clips together for a max length of 60 seconds or upload longer videos that youve recorded outside the app. TikTok also allows you to do duets, where you can place your own video side by side with another video, allowing you to film a reaction video, answer questions, or dance and sing together.

(Keep in mind that, like other social networking apps, TikTok has its own share of privacy issues such as the recent discovery that it was accessing content from the clipboard on iOS devices.)

Once you set up the app, make an account, and start interacting with content, its easy to get lost in the video feed. Heres how to get started. (These instructions were written for an iPhone, but the process for the Android app should be similar.)

Youre ready to start watching videos! But you dont have an account yet. If you want to post content, see and read messages, or get more personalized recommendations, youll need an account. To make one:

When you set up an account, by default, everyone can see your videos, but you might want to set your account to private. This means that people will have to request to follow you in order to see your videos. Heres how to put your account on private:

Now youre ready to watch videos and post your own! The more you use TikTok, the more youll get content tailored to you, which means (at least for me) the more time youll end up spending on the app.

The Verges Julia Alexander recommends taking time to really explore beyond the For You page by scrolling through different hashtags, looking up songs, and finding new creators to follow. To learn more about using the app, read her guide on navigating the culture, content, and niches of TikTok.

Update June 30th, 4:36PM ET: This article was updated to add a mention of recent privacy concerns.

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How to get started with TikTok - The Verge

MTN has launched its 5G offering in South Africa here’s what you need to know – Stuff Magazines

Yes, we know, MTNs 5G service hasnt exactly been kept a secret. Weve all known it was coming, even if the first proper look at it was also our first look at the rollout being postponed. Its here now, thats the important thing.

The new service was made official today during a live stream (because thats normal, now) from MTN, which saw MTN CEO Godfrey Motsa, chief consumer officer Mapula Bodibe and chief technology officer Giovanni Chiarelli outline what subscribers can expect from the service. Heres what weve learned.

MTN opted to do a live test of 5G during its stream, crossing over to someone out in Bryanston, Johannesburg. The demo was nothing but a mobile phone speed test, which nonetheless served up a speed of 608Mbps, along with an upload speed of around 111Mbps. A second speed test took the speeds to more than 750Mbps, with a similar upload speed to the initial test.

5G is supposed to make network congestion a thing of the past, which is something wed like to test on the network in person rather than just believing the marketing hype. Those speeds, no matter the network load, would be impressive.

This is another feature that well want to see in action on a fully-loaded network but MTNs punting the networks gaming skills. The big thing there is latency, which is kinda of the opposite of lag. Being faster than your opponents on the trigger doesnt matter if your connection is slower. Weve seen some serious weirdness in online games in high-latency situations (before the ubiquity of fiber connections). Thatll be a thing of the past but like we said, seeing is believing.

MTNs 5G service is now available but its not available across the country. There are several sites with 5G like, in major South African cities. If youre in Cape Town, Johannesburg, Pretoria, Bloemfontein, Port Elizabeth and Durban, there is 5G coverage available. Its not city-wide in all those locations, but MTNs got ambitions in that line. The company hopes to expand 5G coverage to at least 10 million people in the next 12 months. Eventually, the company hopes to match its 96% 4G coverage in South Africa.

Game streaming technology is the next big target for various tech companies but were not really on the list for it. Thats got a little to do with our local audience footprint but its mostly to do with our lack of internet speed. You need a very fat pipe to stream a PlayStation 4 game over the internet and to a smartphone. MTN demoed just that with gamer Sam Wrist, and the mobile service provider has partnered with Emerge Gaming to deliver games streamed from the cloud. Again, something else were very keen to try for ourselves.

MTN punted the various possible applications for the service, from self-driving cars (which will need to be connected to a reliable, speedy connection for various reasons) to internet-of-things devices becoming more commonplace yes, even in South Africa to creative types being able to upload content to services like YouTube or streaming live to Twitch without hindrance.

Businesses should also get a boost, as tech-based gatherings like hackathons (when those are allowed again) will see more people connected in the same area, streaming, uploading or testing new products without being bottlenecked by a mobile internet connection. This is also the starting point for so-called smart cities, which require constant, fast internet access in order to exist.

MTNs 5G is available in South Africa but the main question on everyones mind is: Where the heck can I actually get it? MTNs got a 5G coverage map available, which.. mostly disappointing at the moment, especially when compared with MTNs LTE coverage.

In order to access 5G, youll need a 5G smartphone (there are three available from 1 July Huaweis P40, P40 Pro and LGs Velvet 5G are the first on the network), while 5G contracts are also available. MTNs also introducing an unlimited data package as well, but youll have to check with MTN stores for those. As for pricing, you can get your 5G contract from R700/pm (for 75GB/pm), all the way up to R1600/pm (for 500GB/pm). Expect your unlimited contract to cost more than that.

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MTN has launched its 5G offering in South Africa here's what you need to know - Stuff Magazines

Posthumanism | Encyclopedia.com

The posthumanist (sometimes called transhumanist) views human dignity as a matter of seizing the opportunity to modify and enhance human nature in ways that include the deceleration or arresting of aging, genetic engineering, the bodily introduction of nanotechnology and cybernetics, reproductive cloning, and even the downloading of mind into immortalizing computers. The anti-posthumanist responds that human dignity lies chiefly in accepting the existing contours of human nature as a gift, and that biotechnological efforts to recreate human nature according to inevitably arrogant and short-sighted images of perfectability should be greeted with severe skepticism. The debate between posthumanists and their critics over the future of human nature is rhetorically sharp; any resolutions can emerge only from inclusive discourse, with significant consensus on specific technologies of human modification arrived at only in the full light of disparate ethical self-understandings of the meaning of humanness both secular and sacred (Habermas 2003).

The posthumanist, it is argued, has the superficial enthusiasm of the adolescent convert to some new image of the human, yet has little or no insight into the human condition or the narrative of history. Rather than free humans of biological constraints in a misplaced effort to transcend humanness by technology, the anti-posthumanist urges, to quote Leon Kass's 1985 publication title, "a more natural science."

But many posthumanists are deeply reflective. The 1974 Nobel Laureate in Medicine, Christian de Duve (2002), thoughtfully urges pursuing the goal of a superorganism as humans reshape life, and raises the question "After us, what?" De Duve warns against fearing the consequences of genetic engineering, or the seduction of a return to nature philosophy. De Duve contends that before even thinking of genetically modifying humans, society should focus on improving the chances of all its members to realize the potential they are born with (through suitable economic, social and family conditions). Fears should be focused on resource exhaustion and catastrophic epidemics. Nevertheless future generations will increasingly interfere with the human genome, he argues, and hopefully the decisions will not be left to a powerful bureaucracy, although a genetic supermarket using the individual choices of parents is not likely to exert more favorable effects on the gene pool.

Posthumanists embrace decelerated and even arrested aging, but only as part of a larger vision to re-engineer human nature, and thereby to create biologically and technologically superior human beings, as the narrative history of posthumanism by N. Katherine Hayles (1999) makes clear. Genetics, nanotechnology, cybernetics, and computer technologies are all part of the posthuman vision, including the downloading of synaptic connections in the brain to form a computerized human mind freed of mortal flesh, and thereby immortalized (Noble 1997). This last scenario of immortalized minds liberated from any biological substrate makes the biogerontological goal of prolongevity appear conservative.

Posthumanists do not believe that biology should in any sense be destiny, and seek a new sort of entity for whom human nature has been more or less overcome (Hook 2003). They urge humans to take human nature into their own re-creative hands as the next great step in evolution, achieving a post-modern morphological freedom. Their argument begins with the claim that, within the boundaries of technology, humans have always been reinventing themselves through applied technologies. Where should the lines be drawn? Besides as the Princeton University physicist Freeman Dyson writes, "the artificial improvement of human beings will come, one way or another, whether we like it or not," as scientific understanding increases, for such improvement has always been viewed as a "liberation from past constraints" (Dyson 1997, p. 76).

What is natural and what is unnatural, anyway? Homo sapiens long ago embarked on the human phase of evolution through technological prowess, and in the future lies nothing more monumental than increased novelty. At one time the very idea of human beings trying to fly was deemed heretical hubris in the light of eternitysub specie aeternitatis. It would be a repetition of this error to argue that redesigning human nature runs afoul of the precautionary appeal to the complexities of evolutionsub specie evolutionis? Should people not set aside trepidation and with confidence rethink themselves in the light of human creativity? The postmodernists have paved the way by purportedly demonstrating that there is no essential aspect to human nature, and vive le difference. So it is that Gregory Stock (2002) introduces the idea of superbiology as human beings take full control of their own biology in turning toward perfection.

David F. Noble (1997) has argued with some plausibility that the roots of this posthumanist project lie in Western European religion, and especially in the ninth century, when the useful arts came to be associated with the concept of human redemption. As a result, there exists a religion of technology that promotes the uncritical and irrational affirmation of unregulated technological advance. In essence technological advance is always deemed good. Noble hopes people can free themselves from the religion of technology, from which they seek deliverance, through learning to think and act rationally toward humane goals.

Millennialist religion is certainly relevant to the posthumanist vision. As Gerald J. Gruman has pointed out, the modern concern with enhancing longevity "stems from the decline since the Renaissance of faith in supernatural salvation from death; concern with the worth of individual identity and experience shifted from an otherworldly realm to the here and now, with intensification of earthly expectations" (Gruman 1966, p. 88).

With the transition to a this-worldly millennialist human horizon, a powerful current of thought emerged in which the goal of significantly extending the length of human life through biomedical science was affirmed. Gruman termed the concept prolongevity as "a subsidiary variant of meliorism, the belief that human effort should be applied to improving the world" (Gruman 1966, p. 89). Carl L. Becker, in his classic work, The Heavenly City of the Eighteenth-Century Philosophers (1932), had similarly interpreted the great ideas of the Enlightenment and the merging goals of science as based on a secularization of the medieval idea of otherworldly salvation, resulting in an advance toward a heaven on earth.

Indeed, Francis Bacon (15611626), a founder of the scientific method, in his millennialist and utopian essay "The New Atlantis" (1627), set in motion a biological mandate for boldness that included both the making of new species or chimeras, organ replacement, and the Water of Paradise that would allow the possibility to "indeed live very long" (Bacon 1996, p. 481). Three centuries before Francis Bacon, the English theologian Roger Bacon (c.12201292) argued that in the future the 900-year-long lives of the antediluvian patriarchs would be restored alchemically. Like many Western European religious thinkers, both Bacons saw death as the unnatural result of Adam's fall into sin. These dreams of embodied near-immortality could only emerge against a theological background that more or less endorses them. There are various other cultural and historical influences at work besides religion, but the initial conceptual context for a scientific assault on aging itself is a religious one (Barash 1983).

The modern goals of anti-aging research and technology, then, are historically emergent, at least in part, from a pre-modern religious drama of hope and salvation, Renaissance science transferred the task of achieving immortality from heaven to earth in the spirit of millennial hopes. The economy of salvation presented by the Italian poet Dante Alighieri was replaced by the here and now. There is a vibrant millennialist enthusiasm in the responsible biogerontologists, who have proclaimed aging itself to be surmountable to degrees through human ingenuity.

For every utopian there is a dystopian. Should individuals, viewing their own prospects for deceleration of aging, pursue such anti-aging treatments when and if they actually become available? Perhaps yes, if this assures one that diseases for which old age is the overwhelmingly significant risk factor can be avoided. But there is an important school of thought that cautions against the development of treatments to slow aging.

Individuals, when confronted with the availability of deceleration, ought to reflect carefully about the choice at hand, raising every question of relevance to themselves and to humanity. One of the wiser minds of the last century, Hans Jonas (19031993), an intellectual inspiration for contemporary anti-posthumanists, articulated these questions quite thoroughly. He wrote in 1985 that "a practical hope is held out by certain advances in cell biology to prolong, perhaps indefinitely extend, the span of life by counteracting biochemical processes of aging" (Jonas 1985, p. 18). How desirable would this power to slow or arrest aging be for the individual and for the species? Do people want to tamper with the delicate biological "balance of death and procreation" (Jonas 1985, p. 18), and preempt the place of youth? Would the species gain or lose? Jonas, by merely raising these questions, meant to cast significant doubt on the anti-aging enterprise. "Perhaps," he wrote, "a nonnegotiable limit to our expected time is necessary for each of us as the incentive to number our days and make them count" (p. 19). Jonas's later essays raising many of these same questions were published posthumously in 1996.

Many of the these issues are echoed in the writings of Leon Kass. Kass for the most part accepts biotechnological progress within a therapeutic mode; his issue is chiefly with efforts to enhance and improve upon the givenness of human nature. He draws on the technological dystopians, such as Aldous Huxley, as well as on the writings of C. S. Lewis (18981963). An early anti-posthumanist, Lewis wrote The Abolition of Man (1944) to defend a natural law tradition: What is, is good, and people should live within their God-given limits. He cautioned against a world in which one class of enhanced human beings would dominate and oppress the other. One might ask, then, if those freed from the decline of aging would become the superior and elite humans, while those who age would be deemed inferior.

In a creative essay, "L'Chaim and Its Limits: Why Not Immortality?" (2001) Kass argues against prolongevity in ways mostly raised by Jonas. He asserts, for example, that the gradual descent into aged frailty weans people from attachment to life and renders death more acceptable. He contends that numbered days encourage a creative depth in human naturea depth that escaped so many of the immortal Greek gods and goddesses, whose often debauched and purposeless behavior made Plato wish to ban them from the ideal Republic. In addition, says Kass, a preoccupation with the continuance of life is a distraction from that which is best for the human soul. Finally Kass writes that in a world transformed by anti-aging research, youth will be displaced rather than elevated, and the parental investment in the young will give way to my perpetuation; and that in such a new world people will grow bored and tired of life, having been there and done that. These assertions are all thoughtful, creative, and appropriately cautionary, because the implications of slowing or arresting aging itself are obviously monumental and mixed. Responsibility to future generations precludes clinging to youthfulness. There is wisdom in simply accepting the fact that humans evolved for reproductive success rather than for long-lived lives Without such wisdom will people lose sight of their deepest creative motives? Possibly.

Another leading anti-posthumanist, Francis Fukuyama challenges those who would march society into a posthuman future, characterized by cybernetics, nanotechnology, genetic enhancement, reproductive cloning, life span extension, and new forms of behavior control. Undoubtedly the ambitions of posthumanists to create a new posthuman who is no longer human are arrogant, pretentious, and lacking in fundamental appreciation for natural human dignity. Fukuyama is also drawn to the dystopian genre and sees much more bad than good in efforts to significantly modify human nature. He argues powerfully that the anti-aging technologies of the future will disrupt all the delicate demographic balances between the young and the old, and exacerbate the gap between the haves and the have-nots. The concerns raised by political scientists such as Fukuyama are ones that the individual decision maker ought certainly to have in mind.

The anti-posthumanists often appeal to nature and character as morally valuable categories. They understand the proper human attitude toward evolved nature as one of humility, awe, and appreciation. Clearly the emerging technological power to control nature does not always constitute progress. The anti-posthumanist exhorts us to work with human nature to get the best out of it, rather than to seek cavalier domination in an effort to recreate what is already good. Better to accept natural limits, or so, anyway, is the spirit of anti-posthumanism. The perfectibility of humankind lies not in modifying the human vessel, but in developing the treasures within, such as compassion, virtue, and dignity.

In summary the natural law traditions represented by anti-posthumanists exhort people to live more or less according to nature, and warn that efforts to depart from that will result in new evils more perilous than the old ones. How can society presume that the brave new world will be a better world? Should not the burden of proof be on the proponents of radical change? What right have people in the early 2000s to impose their own arbitrary images of human enhancement on future generations?

Posthumanist beliefs in the inevitability and desirability of transforming human nature see human beings as essentially technological beings who now have the opportunity to redirect the technological powers that they have been exercising on the nonhuman world onto human nature itself. Just as humans have made the world better through technological mastery, so will they be able to do with human nature, in the first instance by prolonging human life as it currently exists but then ultimately by transforming human life. Such a posthumanist future is the natural outcome of all previous human history and the specific form that a respect for human dignity takes in the twenty-first century.

By contrast, anti-posthumanists suggest that the proper human attitude toward evolved nature is one of humility, awe, and appreciation. Just as past technological manipulations of nonhuman nature have not always been beneficial, so the emerging technological power to control human nature does not always constitute progress.

STEPHEN G. POST

SEE ALSO Aging and Regenerative Medicine;Artificiality;Bioethics;Cybernetics;Cyborgs;Dignity;Freedom;Future Generations;Human Cloning;Human Nature;Nanoethics;Utopia and Dystopia.

Bacon, Francis. (1996). The New Atlantis. In Francis Bacon: A Critical Edition of the Major Works, ed. Brian Vickers. Oxford: Oxford University Press.

Barash, David P. (1983). Aging: An Exploration. Seattle: University of Washington Press.

Becker, Carl L. 2003 (1932). The Heavenly City of the Eighteenth-Century Philosophers. New Haven, CT: Yale University Press.

de Duve, Christian. (2002). Life Evolving: Molecules, Mind, and Meaning. Oxford: Oxford University Press.

Dyson, Freeman J. (1997). Imagined Worlds. Cambridge, MA: Harvard University Press.

Gruman, Gerald J. (1966). "A History of Ideas About the Prolongation of Life: The Evolution of Prolongevity Hypotheses to 1800." Transactions of the American Philosophical Society 56 (Part 9). Philadelphia: American Philosophical Association.

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