David Byrne Once Tried to Kick Tina Weymouth Out of Talking Heads – Vulture

The band, so happy together. Photo: Echoes/Redferns/Getty Images

Within the pantheon of musicians memoirs, Chris Frantzs new book, Remain in Love, is a mostly warmhearted one offering a nice sheen on the debauched era of sex, drugs, and rock and roll. The drummer for Talking Heads, Frantz details the bands humble beginnings at CBGB on through its ascent to Stop Making Sense virtuosity and, perhaps most important, his courtship and 43-year marriage to fellow member Tina Weymouth. When speaking about my family, my friends, and my band, I am not a person who moves on, he writes. I remain and I remain in love.

But we know youre here for the gossip. As expected, Frantz offers his perspective on Talking Heads historic trials and tribulations with frontman David Byrne, who he says dissolved the band and vowed never to reunite after years of exerting unscrupulous creative control. The more successful Talking Heads became, Frantz recalls, the more cold and dyspeptic David became. Read on for the memoirs most egregious Byrne anecdotes as well as other memorable tidbits from the bands time together.

Byrne frequently tried to pass himself off as the sole creator of numerous Talking Heads songs.The first of these instances involved Warning Sign, which appeared on 1978s More Songs About Buildings and Food. Frantz says he wrote the tune alone during his college years. I wrote the lyrics, all of them, while lying on my stomach, he writes in the memoir. David added the words in parentheses and took credit for writing the entire song. It appears that he had forgotten that I wrote these words, and when I confronted him, he said he would correct the credits on future pressings. Another credit issue cropped up around Fear of Musics hit Life During Wartime, which began as a jam session between Frantz and Weymouth, with Weymouth coming up with the vocal melody. Byrne went on to credit himself as the sole writer of the song. This happened to us all the time with David. He couldnt acknowledge where he stopped and other people began, Frantz explains. The story that there was one songwriter in Talking Heads is a myth. The great majority of our songs, particularly the early ones, were always a collaborative effort.

Prior to settling on Talking Heads, the band seriously considered naming themselves The Vogue Dots, the Billionaires, the Tunnel Tones, or the Videos.

Byrne once tried to kick Weymouth out of the band.This occurred during the lead-up to recording Talking Heads: 77, when Byrne felt her bass skills werent developing as quickly as he wouldve liked. Frantz recalls a conversation he had with a sound mixer friend after Talking Heads dispersed for good, in which the man whod helped record the bands early demos remembered how serious Byrne was about her removal at the time:

Many years later, he told me that this was the time David had said to him, So, Im thinking of kicking Tina out of the band. What do you think? He says when he heard this, My brain froze. When he asked why, David said, Shes holding me up and not progressing fast enough. Tina had been playing bass for just over one year.

Frantz says all the band members were still learning how to play their instruments well and how to mesh as a unit, including Byrne and his guitar. It is true that Tina had not played rock and roll before Talking Heads and did not have a repertoire of standard blues and rock bass licks in her musical vocabulary. Her approach was more classical, Frantz notes. To this day, Tina never ever plays the predictable thing. She invents every part anew this was one reason Talking Heads sounded so unique. Byrne tried to broach the subject with Weymouth on one occasion, but he immediately dropped the subject when Frantz entered the room.

Lou Reed advised Byrne never to go onstage in a short-sleeved shirt.The first time they met, Reed said Byrnes arms were too hairy for audiences to handle.

Byrne trashed a hotel room with literal shit. In 1978, Byrne had a bout of diva behavior at the end of one of the bands first European tours. As Frantz writes, Byrne became enraged during their stay at a ritzy London hotel after an operator disregarded his Do not disturb request and repeatedly allowed calls to come through to his room. He had yanked the phone out of the wall and then hit his head on an open cabinet door, Frantz recalls. In a fit of anger, he had smashed some furniture, too. Well, I thought, how predictably rock and roll. Years later, the bands agent told Frantz there was an even dirtier layer to Byrnes behavior that evening: He left a turd on his bed with the message FOR THE MAID. The bands management had to pay hefty fees for the damages. It disturbed us, Frantz explains, to think that one of our own might even be tempted to perform such a lowbrow, copycat stunt.

Byrne started to initiate a band breakup prior to recording Remain in Light.After their final European show on the 1979 Fear of Music tour, Frantz, Weymouth, and the guitarist and keyboardist Jerry Harrison were ambushed by an independent journalist who had just finished a private interview with Byrne, in which the singer stated his plans to leave Talking Heads, effective immediately. Tina and Jerry and I explained to the journalist that we knew nothing about it and left it at that, Frantz writes. Everyone was exhausted. We really needed a break, and none of us wanted to deal with Davids hurtful behavior. Back in New York City a few months later, some jam sessions between the band and producer extraordinaire Brian Eno opened their eyes to a new, fulfilling creative direction. They soon began working on Remain in Light.

Eno was just as bad as Byrne when it came to crediting issues.The honeymoon phase with Eno on Remain in Light was short-lived. Frantz characterizes the producers behavior as being equal parts mercurial and tyrannical, and Eno conspired with Byrne to take larger credit for the album. Eno heavily advocated for the record to be called Remain in Light by Talking Heads and Brian Eno and tried to erase some contributions from Frantz, Weymouth, and Harrison. We all agreed that writers credits on the album cover should be All Songs by David Byrne, Brian Eno, Chris Frantz, Jerry Harrison, and Tina Weymouth. The names were in alphabetical order, Frantz writes. Well, evidently David couldnt help himself and probably Brian was in on it, but when we received our advance copies of Remain in Light, the writing credits on the cover had been changed to All Songs by David Byrne, Brian Eno, Talking Heads.

On the lyric sheet inside the album, the credits had also been changed to All Songs by David Byrne and Brian Eno, except The Overload and Houses in Motion, written by David Byrne, Brian Eno, and Jerry Harrison, with no mention of Frantz or Weymouth. We had been told another untruth by David Byrne, and so had our listeners, Frantz writes. This was especially hurtful because, without our persistence, love, and musicianship, Remain in Light would never have been made.

Byrne replaced Robert Rauschenbergs cover artwork with his own.One of the greatest American artists of all time, Rauschenberg was a massive Talking Heads fan and created a limited-edition album and package design for Speaking in Tongues. A separate Rauschenberg design was meant to be the albums regular release cover, but Byrne went behind our backs, and by the time we found out, it was already a fait accompli. The resulting cover a blue-and-yellow design was Byrnes own creation. Rauschenberg told Tina and me that he felt hurt that David had worked around him, Frantz writes. Still, Bobs cover was a real thing of beauty, and his design ultimately won the Grammy Award for Best Album Cover. Only 50,000 copies of Rauschenbergs cover were printed, and if youre lucky enough to find one today, theyre worth a very pretty penny.

Byrne chose to divorce his wife during Talking Heads Rock & Roll Hall of Fame induction.Frantz fondly recalls the bands 2002 induction ceremony, which doubled as their first reunion in 18 years. (The only downer? It was not our choice to be inducted by Anthony Kiedis of the Red Hot Chili Peppers.) Their jubilant performances aside they selected Psycho Killer, Life During Wartime, and Burning Down the House Frantz said Byrne chose this evening to unexpectedly leave his wife, Adelle Bonnie Lutz, after more than two decades of marriage. Byrne ghosted the inductions fancy after-party, and no one could get in touch with him until the next day. When I finally reached David the following afternoon, I told him that Bonnie was terribly worried about him. Was he at home? He said he would not be going home. He said he was leaving her, Frantz writes. He had chosen the night we were inducted into the Hall of Fame to leave his wife. When I asked him why, he told me, Its time to move on.

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David Byrne Once Tried to Kick Tina Weymouth Out of Talking Heads - Vulture

21% of Canadians worried about losing the roof over their heads if CERB ends: poll – Red Deer Advocate

One in five Canadians is worried about surviving without the Canada Emergency Response Benefit, a poll from Maru/Blue suggests.

The pollsters conducted an online poll of 1,420 randomly selected Canadian adults in mid-July to find out what worries respondents had about CERB and the federal deficit due to COVID-19.

The poll found that 21 per cent of people said that if they stopped receiving CERB, or any similar benefit, they literally could lose the roof over their head.

British Columbians were most likely to be worried about CERB being gone at 27 per cent, with Ontario at 22 per cent, Alberta and Atlantic Canada at 19 per cent, and Manitoba, Saskatchewan and Quebec at 18 per cent.

The poll found that 59 per cent of people were more worried about surviving through the pandemic than the size of the federal deficit, which is projected to reach $343 billion.

The $2,000-per-month emergency benefit is currently scheduled to end at the end of August, with the wage subsidy program set to run through the end of 2020, in hopes that Canadians will move from CERB to the wage subsidy.

As of the the end of June, CERB was budgeted at $80 billion and has so far paid out $53.5 billion in benefits.

Just under half of Canadians 48 per cent believe CERB should be stopped regardless of the impact. That belief was most likely to hold sway in Quebec at 57 per cent, followed by Alberta at 52 per cent, with B.C. at 51 per cent.

The poll found that 70 per cent of Canadians feel like CERB, and other federal spending, was the correct way to respond to the pandemic, regardless of the costs.

However, 74 per cent said they were deeply worried about the federal deficit and how it will affect their taxes, while 76 per cent said they were worried about future federal debt affecting young people.

Coronavirus

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21% of Canadians worried about losing the roof over their heads if CERB ends: poll - Red Deer Advocate

Mississippi kites fly with precision over all our neighborhoods – Houston Chronicle

While wistfully watching the sky, I spotted a sleek, pewter-colored flying object moving swiftly and directly like a military drone.

No drone. Instead, it was a Mississippi kite on a mission, whether to find prey, migrate south, or both. I suspect the bird was nesting in my densely wooded community because Id noticed it several times this summer.

The kite was probably hunting for such prey as grasshoppers and katydids along the edges of a nearby golf course. Or maybe it was about to barnstorm treetops to snatchcicadas.

Hundreds of Mississippi kites will soon be flying in neat squadrons over all our neighborhoods. Theyll be on a migratory journey from breeding grounds in the southern Great Plains and the southern tier of the United States as they join up with local breeding birds. Their winter destination will be the tropical and subtropical regions of South America.

The kites buoyant flight is propelled by a dark-toned three-foot wingspan and crooked back like that of a falcon. A narrow, black tail notched at the tip fans out and torques, like an aerial rudder, to guide rapid maneuvers.

With their 17-inch rocket-shaped gray bodies and pearly-white heads, the birds appear powerful yet elegant. A black face mask encircles piercing red eyes. The bird has yellow-red legs.

Mississippi Kites are social birds that breed, forage, and roost in small colonies.

Strongly monogamous breeding pairs protect their mates from sexual interlopers.

They nest in trees among forests, farming communities, and suburban or urban neighborhoods. Their once large breeding population in East Texas bottomland forests was extirpated by 1914 due to logging and hunting.

Circling flocks of Mississippi kites called kettles may number several hundred or more than a thousand.

They utter quick, high-pitched, two-syllable whistles sounding like the words pheee-phew.

When flying at treetop level, kites will barely pause as they extend their talons to snatch up tree-dwelling insects. Theyll also glide over meadows, yards and golf courses to grab rodents, toads and snakes. Their snake diet earned them the nickname blue snake hawk.

Mississippi kites migrate unhurriedly, sailing over office buildings, homes, sidewalks and walking trails. Theyll sometimes spend several days in local neighborhoods foraging for food.

Come eventide, flocks of the kites will put on an eye-popping show as they spiral down to roost in trees.

The birds were named for the state where naturalists collected the first specimen in 1803. The kite name comes from an Old English word cyta, describing the screaming call of hawks not their fluttering in mid-air.

Gary Clark is the author of Book of Texas Birds with photos by Kathy Adams Clark (Texas A&M University Press). Email him at Texasbirder@comcast.net.

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Mississippi kites fly with precision over all our neighborhoods - Houston Chronicle

Red Deer gardener says compost is the secret to growing great veggies – Red Deer Advocate

Donald Gordon Mann has been seeing some big results in his garden.

The retired police officer, who has lived in Red Deer since 2002, says the use of composting has been his secret to growing high-quality vegetables this year.

Its a matter of getting into the habit of taking things out to the compost bin after you cut them, whether that be scraps of lettuce, cabbage heads or whatever, Mann said while standing in his backyard garden Wednesday morning.

Ill mix the compost with some potting soil, earth and manure, and mix it around.

Mann says he was shocked by how big some of the vegetables in his garden are getting this year, especially the radishes.

The (radishes) kept getting bigger every time I looked. I like to try to get two or three crops every year, because they only take three or four weeks to grow from seed. This year has been phenomenal, Mann said, adding this seasons rain has helped the radishes grow as well.

Mann grows his vegetables in boxes that had previously been used to store old oilfield tools an oil company had given the boxes away to anyone who wanted them.

I thought it was an easy way to garden, he said, adding he owns about six containers.

They were all reinforced and it was something I didnt even have to build, other than a false bottom underneath, because you dont need it all dirt underneath. I built a false bottom and drilled in a few holes, because you need drainage.

I put in some dirt, but said, Why dont I start composting? I started seeing great results.

Mann, who lives with his wife in the Eastview neighbourhood, says gardening is more of a hobby than anything else.

I enjoy just giving the stuff away (to co-workers, neighbours and friends) because we cant eat it all. Its now my summer passion, he said.

When youre gardening, youre kind of in your own world and you can get lost its a good time to think. Then at the end, when everything starts to come, its rewarding.

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Red Deer gardener says compost is the secret to growing great veggies - Red Deer Advocate

Treatment of psoriasis with NFKBIZ siRNA using topical ionic liquid formulations – Science Advances

Abstract

Systemic antibodies targeting tumor necrosis factor (TNF-) and interleukin-17A (IL-17A) are effective in plaque psoriasis. Despite their popularity, safety concerns pose a challenge for systemic biologics. While antiTNF- and antiIL-17A antibodies effectively inhibit respective proteins, we hypothesize that an approach based on local silencing of an upstream target such as NFKBIZ can be advantageous for treating psoriasis. However, effective delivery of small interfering RNA (siRNA) into the skin is a substantial hurdle due to skins barrier function and poor stability of siRNA. Using ionic liquids as an enabling technology, we report on the effective delivery of NFKBIZ siRNA into the skin and its therapeutic efficacy in a psoriasis model. Treatment with IL-siRNA suppressed aberrant gene expression and resulted in down-regulation of psoriasis-related signals including TNF- and IL-17A. These results provide a framework for a topical delivery platform for siRNA.

Psoriasis is one of the most debilitating chronic skin diseases affecting more than 125 million people worldwide with an estimated economic burden of $135 billion/year in the United States (1). Its pathogenesis and the underlying mechanisms are still not fully understood. Nuclear factor B (NF-B), a ubiquitously expressed transcription factor, is considered as the master regulator of immune responses and is implicated in several autoimmune inflammatory diseases including psoriasis (2). Several therapeutics targeting NF-B signaling pathways are available in the clinic; however, concerns regarding the lack of specificity and side effects pose a challenge (3). This is particularly challenging since systemic inhibition of pleotropic proteins like NF-B might lead to serious side effects as they provide essential basal activity as survival factors. Network-centric approaches involving pathway-specific inhibitors have gained considerable therapeutic interests (4). In this regard, infliximab and adalimumab [both antitumor necrosis factor (TNF-) monoclonal antibodies] as well as secukinumab [an antiinterleukin-17A (IL-17A) antibody] have been approved by the U.S. Food and Drug Administration and are claimed to mediate their therapeutic effects through the modulation of NF-B activity (5).

NFKBIZ, a gene encoding atypical inhibitor of nuclear factor B (IB) protein IB, has gained interests for therapeutic intervention due to its crucial role in the regulation of NF-B complexes (6, 7). It is reported to be a direct transcription activator of TNF-, IL-17A, and IL-36inducible psoriasis-related gene products that are involved in inflammatory signaling, neutrophil chemotaxis, and leukocyte activation (811). In addition, strong expression of NFKBIZ in patients with psoriasis could be correlated to elevated IL-36 and IL-17Atype responses (12). Local silencing of NFKBIZ can be advantageous since it can potentially broaden the population of patients that can benefit from the treatment compared with that by a single antibody.

Silencing of NFKBIZ through topical applications of small interfering RNA (siRNA) offers a noninvasive and self-administered treatment option with minimal side effects (13). However, the greatest challenge of this route is that only a limited number of drugs with low molecular weights (up to few hundred daltons) and high octanol-water partition coefficients are usable for successful topical delivery (14). Transdermal and topical delivery of hydrophilic molecules, particularly macromolecules such as antibodies and nucleic acids, remains challenging, owing to their high molecular weights (15). Several reports have showcased topical siRNA delivery using techniques such as spherical nucleic acids (16) and self-assembling framework nucleic acids (17). Microneedles have also been explored for topical delivery of siRNA (18). Methods such as electroporation (19) and peptide carriers have also been explored (2022). Strategies have also been developed to deliver siRNA to treat cutaneous wounds (23, 24). Recently, ionic liquids (ILs) have emerged as a class of versatile materials for topical and transdermal delivery (25). ILs provide a number of potential benefits including tunability, broad applicability, and excellent safety profile (26). ILs have shown potential for delivering siRNA, but their ability to induce a therapeutic effect by silencing a target in vivo has not been demonstrated.

Here, we report a modular IL-based siRNA delivery approach for silencing various genes of interest. Specifically, we have identified a combination of ILs that simultaneously stabilizes siRNA and enhances siRNA penetration into the skin following topical application. We demonstrate the efficacy of the formulation in silencing NFKBIZ in vivo in an imiquimod-induced psoriasis mouse model.

A library of ILs was designed and synthesized to assess siRNA delivery into skin. Cholinium was used as the cation in all ILs due to its known biocompatibility and prior use in humans (27). Several different anions were used to synthesize ILs (fig. S1). Geranic acid was used as the reference anion in the IL library [that is, choline and geranic acid (CAGE) as a reference IL] due to its prior use for transdermal delivery of macromolecules (2830). Other anions were chosen for several reasons. First, anions containing shorter linear carbon chains were chosen in contrast to geranic acid to assess the impact of the chain length on siRNA stability and delivery. Anions with aromatic groups were chosen since they might interact with the stacked RNA base pairs via electrostatic, hydrophobic, and polar interactions. All ILs were prepared at a stoichiometric ratio of 1:2 (cation:anion) and were assessed for stability and siRNA delivery. Of the ILs synthesized, CAGE, choline and dimethylacrylic acid (CADA), choline and isovaleric acid (CAVA), and choline and phenylpropanoic acid (CAPA) remained as a viscous liquid at room temperature (RT), whereas choline and 4-phenolsulfonic acid (CASA), choline and phenylphosphoric acid (CAPP), and choline and biphenyl-3-carboxylic acid (CABA) solidified or formed a gel (fig. S1). Representative 1H nuclear magnetic resonance (NMR) spectra can be found in fig. S1, confirming the successful synthesis and purity of the ILs. In addition, since both interleukin and ILs have been denoted as IL, for the purpose of clarity, all interleukins are referred by a numerical value throughout the manuscript.

We first assessed the effect of ILs on siRNA stability. Circular dichroism (CD) spectroscopy of siRNA incubated with aqueous solutions of individual ILs at 50% (v/v) concentration revealed notable alteration in the helix backbone (confirmed from the negative band at 210 nm) in the presence of CAGE, CADA, and CABA. On the other hand, CAVA and CAPA retained the secondary structure of siRNA (Fig. 1A). Bands obtained from the native gel electrophoresis complemented with the CD results (Fig. 1B). The improved stability of siRNA in the presence of CAPA suggested the possibility of synergistic effects between the ILs prepared from two structurally different anions. Consequently, we assessed the effect of IL mixtures on siRNA stability to determine whether the compatibility of CAPA with siRNA might offer additional protection against the adverse effects of CAGE and CABA on the siRNA structure. The combination of CAGE (25% v/v) and CAPA (25% v/v) led to a prominent band indicative of retention of siRNA structure (fig. S1).

(A) CD spectra of siRNA in phosphate-buffered saline (PBS) following incubation with IL (50% v/v) for 30 min and dialysis for 72 hours. (B) Representative native gel image of siRNA following IL incubation. bp, base pair. (C) Representative confocal images of siRNA (red) in the different skin layers (a) stratum corneum (SC), (b) epidermis, and (c) dermis, in the presence of IL combination (CAGE + CAPA) mixed at a ratio 1:1 following 24 hours of incubation. Left to right: Merged, Cy5, differential interference contrast (DIC). Scale bars, 50 m. (D and E) Transport of Cy5-labeled siRNA in the presence of individual ILs with concentration of 50% (v/v) (D) and combination of ILs at 50% (v/v) (E) into the different layers of skin determined by the tape-stripping method (n = 3). Data are averages SEM and were determined to be nonparametric by normality test and statistics by Kruskal-Wallis test for (D) and (E). *P < 0.05.

The individual ILs and their combinations were then evaluated for epidermal permeation of Cy5-labeled siRNA into porcine skin in Franz diffusion cells (FDCs) (Fig. 1C). Some epidermal uptake for naked siRNA was seen in controls. CAGE exhibited the highest delivery among all tested ILs (Fig. 1D). About 0.20 nmol/cm2 of siRNA was delivered into the epidermis in the presence of CAGE (50% v/v) compared with 0.07 nmol/cm2 in case of naked siRNA. Since 50% CAGE had a potential effect on the siRNA structure, we also measured the ability of IL combinations to deliver siRNA into skin. A combination of CAPA and CAGE (25% v/v each) led to ~0.4 nmol/cm2 siRNA getting delivered into the skin (Fig. 1E). Because the CAGE + CAPA combination yielded the highest epidermal delivery as well as high stability, it was selected as the lead formulation for further studies (fig. S2).

Molecular dynamic (MD) simulations were performed to explore the mechanism by which the IL combination (CAGE + CAPA) stabilizes the RNA. It is evident from the snapshots of unit cells within 10 of RNA that geranic acid in CAGE is responsible for forming aggregated clumps, leading to separation of geranic acid from choline, water, and the RNA molecule (Fig. 2, A and B). Addition of phenylpropanoic acid to CAGE led to a more consistent distribution of the three molecular species/ions in the IL solution (Fig. 2, C and D). Furthermore, the proximity of phenylpropanoic acid molecules to the RNA molecules, possibly due to the presence of hydrophobic aromatic rings unlike its aliphatic counterpart (geranic acid), confirms its crucial role in intercalating between the stacked RNA base pairs contributing to the RNA solvation and stability.

(A and B) Snapshot of simulation unit cell for CAGE and siRNA (A) and CAGE components found within 10 of siRNA (B) under periodic boundary conditions for 500 ns. (C and D) Snapshot of simulation unit cell for the optimized IL combination (CAGE and CAPA, 1:1) and siRNA (C) and IL species found within 10 of siRNA (B) under similar conditions. (E and F) Radius of gyration (RGYR) (E) and root mean square deviation (RMSD) (F) obtained over the course of 500 ns for CAPA and the IL combination (CAGE and CAPA) in contrast to CAGE (control).

Structural properties of RNA were assessed by performing simulations over the course of 500 ns and measuring the root mean square deviation (RMSD) and radius of gyration (RGYR). The RGYR obtained for the CAGE group was consistent up to 150 ns and started decreasing toward the end of the simulation, indicating the inconsistent compactness of the system (Fig. 2E). In contrast, the increased and consistent RGYR obtained for the IL combination (CAGE + CAPA) over 500 ns aligns well with the improved IL-RNA interaction results. Such improved interactions and compactness for the optimized IL system with the RNA could also be attributed to the increase in the relative molecular mobility or reduced local viscosity upon addition of phenylpropanoic acid to CAGE. In addition, lower viscosity of the IL system may weaken the intramolecular strain placed on the RNA by the IL and is a possible explanation for the reduced RMSD observed in the case of CAGE + CAPA (Fig. 2F).

To assess the insertion and translocation of the IL into the lipid bilayers, simulations of the lipid bilayer in the presence of IL were conducted (Fig. 3, A to C). In addition to improving the stability and solvation of the RNA, the compact packing of the ionic species leading to the formation of aggregates seems to augment the ILlipid membrane interactions. The aggregates formed by the individual ionic moieties appear to enable a continuity between the IL system and the molecules, making up the lipid bilayer. It is possible that the collective mass of the ionic aggregates plays a crucial role in facilitating membrane permeation in addition to ILs, particularly geranic acids ability to extract or fluidize lipids as previously reported (26).

(A) Lipid bilayer simulation with the aggregates of choline, geranic acid, and phenylpropanoic acid highlighted with a circle. (B) Enlarged view of the ionic species from the circle depicting closed interaction of ionic species with the phospholipid heads and tails. The aggregate contains all three ionic species contributing to the interaction with the lipid membrane. (C) Representative snapshot viewing perpendicular to membrane in the plane of the lipid bilayer. (D and E) Average thickness of the lipid membrane (D) and average area per lipid (E) over the course of simulations in the presence of CAPA and the IL combination (CAGE and CAPA) in contrast to CAGE (control). All data are averages SEM and were determined to be nonparametric by normality test and statistics by Kruskal-Wallis test for (D) and (E). ****P < 0.0001.

The relative effect of the ILs including CAGE, CAPA, and CAGE + CAPA on membrane dynamics was assessed by measuring the average thickness of the lipid bilayer in the presence of ILs over a simulation time of 350 ns. The highest thickness was observed in the presence of CAGE (50% v/v), indicating greater IL intercalation within the lipid bilayer. Similar thickness was noted for the water and CAPA (50% v/v) groups, while CAGE (25% v/v) with CAPA (25% v/v) led to a higher thickness (Fig. 3D). The MD simulation snapshots highlight the dynamics of interactions of the individual ionic species in the IL with phospholipid membrane. Conclusive intercalation of the ionic species of the IL combination with the bilayer was detected (Fig. 3B). Furthermore, upon visualizing the trajectories of the individual ionic species within the CAGE + CAPA simulation, we were able to observe reduced mobility of geranic acid relative to phenylpropanoic acid (fig. S3). When focusing on an IL aggregate that consists of all three IL species (choline, geranic acid, and phenylpropanoic acid), we observed that each geranic acid molecule tends to remain in contact with the aggregate over the course of the simulation, while choline and phenylpropanoic acid are able to move between both the aggregate of heterogeneous species and the bulk solvent making up the rest of the system. This increase in mobility likely causes a change in the distribution of local viscosities across the system. When visualizing the head groups of lipids, which are in contact with the aggregate, we observe that the head groups occupy a larger area per lipid. This is demonstrated by a more spread out distribution of individual molecular trajectories within the area of the IL aggregate. This expansion of space between the lipids is caused by intercalation of the IL with the membrane and subsequent displacement of the lipid species. As the aggregation induces localization of the effects of IL on the bilayer membrane, it is likely that aggregation, with low constituent turnover with the bulk solvent, may lead to uneven membrane disruption as well as differences in the local viscosity. This heterogeneous distribution of membrane disruption may account for the wide distribution of area per lipid values seen over the course of the simulations in CAGE when compared with the other IL systems (Fig. 3E). Overall, these results signify the contribution of aggregate turnover for ILs in translocating RNA across lipid bilayers.

The optimized CAGE + CAPA IL formulation was evaluated for toxicity in vivo in mice. ILglyceraldehyde-3-phosphate dehydrogenase (GAPDH) siRNA formulation (25 l) was applied topically for four consecutive days to the dorsal skin of SKH-1 elite (SKH-1E) hairless mice (Fig. 4A). No signs of inflammation, redness, and/or irritation were observed for the IL-treated animals (fig. S4). Skin tissue was further harvested, and sections were cut and stained for histopathology and toxicology markers. Groups treated with the IL formulation exhibited no signs of epidermal thickening and keratinocyte hyperproliferation and were equivalent to the untreated and/or naked siRNA-treated animals (Fig. 4B and fig. S4). We also tested TNF- gene expression levels in healthy mice. Animals treated with naked siRNA were statistically equivalent to the untreated animals. Mice treated with IL-GAPDH siRNA and ILsiCon (control siRNA used for subsequent experiments) demonstrated slightly lower TNF- mRNA transcripts compared with the untreated group (fig. S4). Such inhibition of TNF- expression might potentially arise from the inherent properties of the individual components of the ILs and need to be studied in future studies.

(A) Schematic illustration of the topical application schedule. (B) Representative histology [hematoxylin and eosin (H&E)] images of the skin tissue 5 days after topical application of IL-siRNA. Scale bars, 100 m; magnification, 10. (C) Confocal images of epidermal accumulation of Cy5-siRNA (red) with and without IL in a mouse skin tissue. Scale bars, 50 m. (D) GAPDH mRNA expression was measured by qPCR. -Actin mRNA expression was used for normalization. Data are averages SEM and were determined to be nonparametric by normality test and statistics by Kruskal-Wallis test. *P < 0.05, ***P < 0.001, and ****P < 0.0001. (E) GAPDH levels in the skin samples were determined using a GAPDH enzyme-linked immunosorbent assay. Data are averages SEM, statistics by one-way ANOVA with Tukey HSD posttest. ****P < 0.0001 (control, n = 5; naked siRNA, n = 5; IL-siCon, n = 4; IL-siRNA, n = 8). Photo credit: N.K., Harvard University.

Cy5 fluorescence within the epidermis was measured in healthy mice following transdermal application for four consecutive days. Confocal images revealed a marked increase in Cy5 fluorescence in the epidermis for the IL-treated group compared with the naked siRNA in mice (Fig. 4C). Upon determining the GAPDH gene silencing efficiency using quantitative polymerase chain reaction (qPCR), the expression levels of GAPDH were found to be reduced 4.5- and 8.6-fold for the IL-siRNAtreated group in contrast to the naked siRNA and untreated mice, respectively (Fig. 4D). A slight decrease in the GAPDH mRNA expression was also observed for the naked siRNAtreated group. Consecutively, it was necessary to ascertain if the change in GAPDH mRNA expression translated into protein reduction. Consistent with the gene knockdown results, the IL-siRNAtreated group demonstrated a statistically significant decay (2-fold) in the GAPDH protein expression compared with all the other treatment groups (Fig. 4E). The reduced GAPDH mRNA expression for the naked siRNAtreated group did not down-regulate GAPDH protein expression.

The ability of NFKBIZ siRNA to treat psoriasis was tested using CAGE + CAPA as a topical formulation. Following induction of psoriasis and topical application of IL-NFKBIZ siRNA formulation (Fig. 5A), skin tissue was harvested and analyzed. Macroscopically, local knockdown of NFKBIZ in the dorsal skin markedly reduced imiquimod-induced inflammation, showing reduced erythema and scaling in the area where IL-NFKBIZ siRNA was applied compared with the untreated, IL-treated, and IL-siContreated groups (Fig. 5B and fig. S5). Hematoxylin and eosin (H&E) staining of skin sections from the mice revealed that the knockdown of NFKBIZ by IL-siRNA reduced epidermal thickening, acanthosis, hyperkeratosis, and club-shaped rete ridges (Fig. 5C and fig. S5). Likewise, immunohistochemistry (IHC) analysis revealed hyperproliferation of keratinocytes in the untreated, IL-treated, and IL-siContreated groups, whereas the group treated with IL-NFKBIZ siRNA exhibited lack of keratinocyte proliferation (Ki67 staining) (Fig. 5D and fig. S5). The common characteristic features of imiquimod-induced skin inflammation (erythema and scaling) were scored daily throughout the induction/application period. Individual scores for erythema and scaling demonstrated fair reduction starting from day 3 with topical IL-siRNA application (Fig. 5, E and F). Maximum cumulative scores were obtained for the untreated and IL-treated groups and were markedly lowered in the IL-siRNAtreated group (fig. S6). Double skin-fold thickness (DSFT) for measuring skin thickness did not yield major differences between the groups (fig. S6). In addition, the heat map and mRNA analyses indicated a substantial reduction in expression of NFKBIZ and other psoriasis-related gene products (fig. S7) in comparison with the untreated and IL-siContreated groups (Fig. 5, G to J, and fig. S8). Upon IL-siCon treatment, most genes were up-regulated, including NFKBIZ, TNF-, cytokines (IL-17C, IL-19, IL-22, IL-36A, and IL-36G), chemokines (CCL20), and antimicrobial proteins (LCN2 and DEFB4) (Fig. 5G). Some down-regulation of TNF- and IL-17A mRNA expression was observed in healthy mice upon treatment with IL alone (Fig. 5, I and J) and suggests additional inherent properties of ILs, which could be explored in future studies. Future studies should also focus on determining the dose-response curve of the therapeutic effect of siRNA-IL.

(A) Schematic illustration of the application schedule for disease induction and IL-siRNA topical administration. (B) Psoriasis-induced mice were treated topically with IL-NFKBIZ siRNA and were compared with untreated and IL-applied groups. (C) H&E staining of the psoriasis-induced skin sections from the mice with and without treatment. Scale bars, 50 m; magnification, 10. (D) Skin sections from the mice were analyzed for keratinocyte proliferation (proliferation marker, Ki67) by IHC. Scale bars, 100 m. (E and F) Erythema and scaling scores obtained by blindly scoring using the human PASI scoring system daily on a scale from 0 (no alteration) to 4 (very distinct alteration). (G) Heat map for the expression levels of various psoriasis-associated genes following treatment with IL-NFKBIZ siRNA in comparison with the untreated (control) and IL-siContreated groups. (H to J) mRNA expression levels were measured by qPCR, and -actin mRNA expression was used for normalization for NFKBIZ, TNF-, and IL-17A, respectively. Data are averages SEM, statistics by one-way ANOVA with Tukey HSD posttest. *P < 0.05, **P < 0.01, and ****P < 0.0001 (control, n = 4; IL, n = 4; IL-siCon, n = 4; IL-siRNA, n = 8). Photo credit: (B) A.M., Harvard University; (C and D) N.K.

Limited understanding of key inflammatory signaling pathway regulators and the chronological order of the underlying mechanisms presents a challenge in the treatment of psoriasis. Signaling pathways including NF-B, Janus kinase (JAK)/signal transducer and activator of transcription (STAT), and p38 mitogen-activated protein kinase have recently been found to play a major role in the pathogenesis of this complex disease (31). NFKBIZ, a gene encoding IB, is a crucial transcriptional coactivator mediating downstream effects of an array of specific inflammatory cytokines and is particularly imperative in the light of recent findings by Johansen et al. (6) and Mller et al. (12), which indicated IB to be a key modulator of IL-17A, IL-23, and IL-36 (32). Thus, targeting NFKBIZ/IB to inhibit proinflammatory signaling pathways and production of psoriasis-related gene products is a viable strategy for psoriasis treatment. Clinically, antibodies targeting TNF- and IL-17A have shown promise in meeting the primary endpoints and improving the disease condition (33). However, as biologics, these antibodies have challenges of potential systemic toxicity, generation of anti-antibodies, and high cost.

Here, we present an IL combination capable of improving epidermal accumulation and delivery of RNA through skin. We hypothesized that a combination of ILs would stabilize the siRNA and, at the same time, would improve its penetration. We validated this hypothesis in an imiquimod-induced psoriasis-like skin inflammation model that resembles plaque-type psoriasis in humans. Topical application of IL-siRNA for four consecutive days generated substantial reduction in the levels of inflammatory cytokines and an array of psoriasis-related gene products.

CAGE + CAPA IL formulation offers several advantages over other transdermal drug delivery systems. The components of the IL formulation, choline bicarbonate, geranic acid, and phenylpropanoic acid, have been proven safe or GRAS (generally recognized as safe) chemicals and provide a strong foundation for the safety of ILs. In addition, simple synthesis and scale-up processes, high solvating power, and tunability offer additional advantages over other volatile organic solvents. This system is particularly suitable for transdermal delivery of nucleic acids due to both its complex intercalation between the stacked RNA base pairs and aromatic rings of the IL, and enhanced interaction with the lipid bilayer.

Our results demonstrate that ILs can complex with nucleic acids without compromising the bioactivity, thus making them ideal for transdermal drug delivery. The salt metathesis or anion exchange reaction for IL synthesis is particularly advantageous because it does not require integration of harsh organic solvents for siRNA delivery. The individual IL components could be modulated to interact with nearly any nucleic acid based on the binding characteristics and molecular mechanism of interactions.

Tunable ion stoichiometry and physicochemical properties are other key features of IL-based systems. Previous work in our group has indicated the role of interionic interactions in solvation and partitioning of the active ingredient into the skin (34). In addition, Chandran et al. (35) have demonstrated the importance of electrostatic interactions and groove binding associations of ILs in DNA stability. Hitherto, the role of ILs in improving the stability and solvation of siRNA has not been comprehensively explored. We systematically varied the anionic component of the IL with structural similarity to geranic acid and/or containing an aromatic ring at a stoichiometry ratio of 1:2 and developed an in-house cholinium-based IL library. We observed that the anions of the ILs that contained aromatic rings generally solidified or formed a gel at RT except phenylpropanoic acid. Excellent siRNA stability was observed in the presence of CAVA, CAPA, and CAGE + CAPA in comparison to other ILs and combinations, possibly due to superior interactions with the siRNA. The IL combination CAGE + CAPA generated the highest epidermal accumulation of siRNA, notably higher than any individual ILs and/or combination.

The best performing IL combination that we identified in this study, CAGE + CAPA, demonstrated consistent distribution of the three ionic species through MD simulations, indicating improved molecular mobility and lower viscosity contributing to enhanced solvation effects. Furthermore, MD simulation snapshots revealed close association of phenylpropanoic acid with the RNA molecules, which could be possibly attributed to a combination of hydrophobic and polar interactions, - stacking, and/or intercalation between stacked RNA base pairs, leading to enhanced RNA stability. RGYR and RMSD measurements obtained from simulations over the course of 500 ns further confirmed improved IL-RNA interactions.

It is also important to understand the magnitude of IL-mediated lipid bilayer modulation. MD simulations revealed the crucial role of aggregation of ionic species in improving membrane permeation with the highest bilayer thickness obtained for CAGE (50% v/v) followed by CAGE + CAPA. Such observations from the simulations further establish geranic acid as the main driver in the translocation of the IL combination through the lipid bilayers, which is consistent with experimental results. While it seems that phenylpropanoic acid has a minor role in improving bilayer permeation by lowering the local viscosity of the overall IL system, we believe that it is also responsible for fluidizing the membrane with the formation of dynamic pores. It was earlier reported that deprotonated aromatic carboxylic acids, such as phenylpropanoic acid, permeate bilayers several orders of magnitude faster than that expected from the pH partition hypothesis, and their permeation is fully controlled by the anions at the physiological pH (36). On the basis of these results, we speculate that these ILs assist in crossing the cellular barriers to deliver siRNA into the cytosolic compartments.

To assess biocompatibility of CAGE + CAPA, we conducted a histological evaluation of skin on the fifth day, which coincided with the total duration of topical application. We did not observe any macroscopic changes in the skin structure, epidermal thickening, and keratinocyte proliferation in the IL-treated groups. Further investigation of inflammatory cytokine levels did not reveal any statistically significant increment in TNF- mRNA compared with the untreated groups. Some of the IL-treated groups demonstrated a decrease in the TNF- mRNA levels, which might be possibly due to the presence of IL and need to be further investigated. Marked inhibition of GAPDH mRNA and protein expression was observed in the IL-GAPDH siRNAtreated groups.

NFKBIZ has been previously demonstrated to play a crucial role in the gene transcription of several proinflammatory cytokines and antimicrobial peptides responsible for the pathogenesis of psoriasis (6, 12). Using an imiquimod-induced psoriasis model, we further demonstrated that local silencing of NFKBIZ following topical application of IL-NFKBIZ siRNA formulation impaired expression of psoriasis-related gene products under in vivo conditions. IL-siRNAtreated mice exhibited substantially reduced skin pathology including reduced erythema and scaling, less epidermal thickening, and keratinocyte proliferation. The local increase in mRNA levels of some of the inflammatory cytokines and related gene products for the IL-siCon and IL-treated groups in comparison with the untreated group could be attributed to imiquimod. Local silencing of NFKBIZ resulted in a strong inhibition of crucial proinflammatory cytokine mRNA levels including IL-17A, IL-23, and IL-36. The downstream effects of local NFKBIZ silencing were also validated and are consistent with the previously reported effects of intradermal injection of IB siRNA (6). Because mouse skin is generally much more permeable than human skin, detailed studies of quantification of skin penetration were not performed in vivo.

In summary, we have developed a transdermal IL platform capable of delivering RNA to the epidermis and have combined this framework with an array of gene screening to support NFKBIZ as a key signaling target gene in psoriasis treatment. The IL formulation retained the bioactivity of the siRNA and generated notable target gene abrogation upon topical application in an imiquimod-induced psoriasis-like skin inflammation model. The optimized IL formulation did not show toxicity and is acceptable for repeated applications. This platform is amenable to broad applications to nucleic acids and can be easily manufactured and scaled up. This platform could empower transdermal drug delivery for the treatment of dermatological conditions and help augmenting long-term therapeutic efficacy by targeting such common mediators. Upon further studies focused on assessment in large animals and comparison with clinical standard of care, the method described here opens a potential option for psoriasis treatment.

The cholinium-based IL library was synthesized as described previously (26). Briefly, the cation, choline bicarbonate, and various anions were mixed at a 1:2 ratio to prepare ILs following salt metathesis reaction. The anions were dissolved in a minimum volume of ultrapure water or ethanol/methanol based on the solubility and were reacted with choline bicarbonate at 40C for 24 hours. The resulting IL solution was dried using a rotary evaporator at 20 mbar at 60C for 2 hours. The residual water was removed in a vacuum oven at 60C for 48 hours. The ILs that were viscous at RT were characterized via NMR with dimethyl sulfoxide (DMSO)d6 on an Agilent DD2 600-MHz spectrometer (Supplementary Materials and Methods). ILs were mixed with RNA (100 M) at a volumetric ratio of 1:1 and incubated for 30 min at RT. The RNA-IL solutions (1 ml) were dialyzed against 10 mM sodium phosphate buffer for 72 hours using Dialysis Cassettes (10,000 molecular weight cutoff, Invitrogen). The concentration of RNA was confirmed and normalized using a NanoDrop instrument (Thermo Fisher Scientific). The stability of the RNA in the IL solution was determined using CD and gel electrophoresis (Supplementary Materials and Methods).

MD simulations were performed using OpenMM MD package and the AMBER force fields ff14SB and GAFF. Three-dimensional SD files for each of the IL species were downloaded from PubChem and parameterized with Antechamber before preparing simulation input topologies with LEaP. To generate starting coordinates for the lipid membrane simulations, PACKMOL was used to build a bilayer consisting of 100 phosphatidylcholine (POPC) molecules for each of the leaflets. The remaining contents of a 60- cube consisted of ~1:1 water (TIP3P) and IL, charge balanced with Na+ and Cl. A 500-ns simulation was performed for each of the systems under periodic boundary conditions. For the simulations of siRNA, a helical starting structure for the nucleic acid was generated with Avogadro (37) before being placed in a simulation box consisting of ~1:1 water and IL for simulation under periodic boundary conditions for 350 ns. Analysis of MD trajectories was performed using the python library MDAnalysis for RGYR and RMSD of siRNA. Visual molecular dynamics (38) plugin MEMBPLUGIN (39) was used to perform analysis of membrane trajectories.

Skin penetration studies were performed using porcine skin in FDCs, as described previously (40). A total volume of 20 l of Cy5-labeled RNA (50 M) in IL solutions was applied to the porcine skin surface and was incubated at 40C for 24 hours under occlusive conditions with moderate stirring. The skin permeability of RNA was visualized and quantified using confocal microscopy and tape-stripping techniques, respectively (Supplementary Materials and Methods).

All animal studies were performed at the Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University. Procedures and studies conducted were approved by the Institutional Animal Care and Use Committee of the Faculty of Arts and Sciences, Harvard University, and were consistent with all applicable regulations. ILs carrying GAPDH (custom siRNA, sense seq: 5-GUGUGAACCACGAGAAAUAUU-3, antisense seq: 5- AAUAUUUCUCGUGGUUCACAC-3; Dharmacon), siCon (catalog no. D-001810-02-50; Dharmacon), and NFKBIZ siRNAs (catalog no. J-040680-06-0050; Dharmacon) were applied topically to healthy and imiquimod-treated SKH-1E hairless mice (Charles River), respectively. A blind scoring system similar to the human Psoriasis Area and Severity Index (PASI) score was used to measure the degree of severity, erythema, and scaling on the back of mice. In addition, skin thickness was monitored by the DSFT of dorsal skin of the mice with caliper measurements throughout the disease induction and treatment period (Supplementary Materials and Methods).

Flash-frozen skin tissues were pulverized to form a powder and homogenized in QIAzol Lysis Reagent to prepare the tissue lysates for qPCR. The mRNA levels were quantified and normalized following the manufacturers protocol. The relative abundance of mRNA transcripts and silencing in treated groups was normalized to the housekeeper gene (-actin). The mean normalized siRNA treatment values were then plotted with their SEM (Supplementary Materials and Methods).

One-way analysis of variance (ANOVA) and statistical analyses were performed using GraphPad Prism software (GraphPad Software Inc.). Results are depicted as average SEM. Two-tailed Students t test was used for comparison between two groups. Parametric data were analyzed by one-way ANOVA followed by Tukeys honestly significant difference (HSD) post hoc tests. Kruskal-Wallis tests were performed for nonparametric data. Statistical tests are indicated in the figures. P < 0.05 was considered statistically significant.

More:

Treatment of psoriasis with NFKBIZ siRNA using topical ionic liquid formulations - Science Advances

Where Do The Texans Rank In ESPNs Future NFL Power Rankings? – Battle Red Blog

ESPNs experts smashed their heads together and came up with a future NFL Power Rankings. Jeremy Fowler, Louis Riddick, Seth Walder, and Field Yates used a scale of 0-100 to rate each teams quarterback, remaining (non-QB) roster, draft, front office, and coaching. They then proceeded to tally and weight teams by roster (30%), quarterback (20%), draft (15%), front office (15%), and coaching (20%) to create an overall score in an attempt to make a subjective task as objective as possible.

After all of this, the Texans were ranked 23rd because Deshaun Watson is really good and everything else is kind of bleak. This is what ESPN had to say:

23. Houston Texans

Overall score: 73.5

Why theyre here: The Texans have had more recent success than any team in this tier of the rankings, with a chance to remain quite competitive as we proceed ahead. Houston traded away its most productive player other than Deshaun Watson this offseason in DeAndre Hopkins and has made a long series of audacious and roundly questioned trades that are often a primary talking point when assessing how the team will fare ahead. Yates

Biggest worry: Its hard enough being a head coach in the NFL. Unless your name is Bill Belichick, its almost impossible to be both the HC and the GM and do them both at a high level in the salary cap era. Bill OBrien is going to have to answer the bell in a big way while wearing both hats if the Texans are going to make noise in the AFC. Riddick

Looking ahead: Receiver has too many durability questions for long-term comfort. The Brandin Cooks-Will Fuller V-Kenny Stills combo might just work for 2020, but Fullers knee issues and Cooks concussion history should lead the Texans to draft receiver help just in case. Tight end Darren Fells can still play but doesnt have much time left at age 34. Pairing a dynamic tight end with Watson for the next decade would be a prudent move by OBrien. Fowler

Top stat to know: In exchange for Laremy Tunsil, Stills, a fourth-round pick and a sixth-round pick, OBrien dealt two first-round picks and a second. Thats not a stat, but that trade is a year old and I still cant get over it. Nothing depicts Houstons front office problem quite like that. Walder

In the AFC South, the Texans ranked behind both the Colts (10th) and Titans (11th) but way ahead of the Jaguars, who were ranked dead last in the entire league. What do you think about Houstons ranking and the methods used to determine it?

See more here:

Where Do The Texans Rank In ESPNs Future NFL Power Rankings? - Battle Red Blog

The GOP’s rising tide of unpopularity – The Week

One of our major political parties is going to win Texas and its 38 electoral votes in November. Spoiler alert: It is not going to be the one that has not carried the Lone Star State since 1976, despite quadrennial fantasy pieces by pundits. Democrats should also not get too carried away about the state's House delegation, which is likely to remain red for the foreseeable future.

This doesn't mean the GOP has anything to celebrate going into this fall's congressional elections. The majority Republicans enjoyed at the beginning of Donald Trump's presidency disappeared two years later, leaving them with nothing to show for it except tax cuts, i.e., the only thing the party does when it controls both houses of Congress and the presidency. A net gain of 20 seats that would return them to power in the lower chamber is well-nigh impossible. A modest shift of five or so is just about imaginable, but it's far more likely to go in the other direction.

This, one suspects, is why even in Texas they are suddenly behaving like a losing party, which is to say one that cares more about fleecing the most reliable portion of its donor base than it does about trying to win a majority. Hence the recent election of Allen West, the one-term congressman from Florida, as chairman of the Texas Republican Party. When you put a carpet-bagger who was nearly court-martialed for torture in charge of boring logistical tasks like deciding what brand of seltzer you are going to serve at official GOP events because you know he is still popular with aging Tea Party types on Facebook, you know where you are.

Meanwhile Democrats are likely to have a good year in the House even if Trump is re-elected this fall. It's difficult to imagine them passing any meaningful legislation in such a scenario, especially with the Senate likely to remain under GOP control. Instead we can look forward to Impeachment 2: Electric Boogaloo. The only question is whether the pretext for this unprecedented move will be Trump's handling of the pandemic, a throwaway line from a recently published memoir, or spurious allegations of receiving foreign assistance during the election.

What if Joe Biden wins? Even then, we should not necessarily expect the kind of midterm anti-White House backlash that has delivered the House to opposition parties during the first terms of three of our last four presidents, in 2018, 2010, and 1994 respectively. This is true for a number of reasons, but the most important is that in the long run, the math in the House, as opposed to the Senate, is not favorable to Republicans. Democrats might complain about the built-in advantage for the party of rural America in the upper chamber, but the corollary in the lower one is the reality that even in the reddest of red states, cities and suburbs are getting bluer with each election cycle. In 2018, the GOP won only a quarter of districts in which a higher than average percentage of residents had at least a bachelor's degree. As Tom Davis, the former congressman and chairman of the Republican National Committee, put it recently, the suburbs were "the base of the Republican Party just a decade and a half ago. And there just aren't enough rural voters to make up for those kind [sic] of losses. It means for the Republicans that instead of picking up seats in the House, that the bleeding could continue."

This is the real blue wave that the GOP faces, not a sudden unexpected tsunami, but a rising tide of unpopularity that will sooner or later become a bore and lead. To keep their heads above water, Republicans will either have to figure out how to retake the suburbs (which would involve, among other things, disavowing Trump when he leaves office and likely abandoning the culture-war issues that keep the party's rural white working class base going to the polls) or somehow make themselves appealing to socially conservative Black and Hispanic voters.

My guess is that they are going to keep getting wet.

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The GOP's rising tide of unpopularity - The Week

James Earle Fraser and the Legacy of His Vanishing Indian – Governing

The American Museum of Natural Historys recent decision to remove the statue of Theodore Roosevelt from its Central Park entrance gives us all the opportunity to revisit and rethink a wide range of things we have taken for granted in American history and American memory. Although the Roosevelt debate has largely focused on the statue groups depiction of him as a cowboy or Rough Rider on horseback, leading a Native American on one side and an African gun bearer on the other to a more civilized future, it might be useful to give some attention to the distinguished American sculptor who fashioned the sculpture.

James Earle Fraser (1876-1953) was born in Winona, Minn., but he grew up near Mitchell, S.D. His father was a railroad engineer who spent the summer of Frasers birth in Montana gathering up the remains of George Armstrong Custers Seventh Cavalry members who perished at the Battle of the Little Bighorn on June 26, 1876, to return them to their homes in the East. Young Fraser discovered his artistic vocation while carving scattered chunks of limestone near his home. He was inspired by the architecture and sculpture he observed at the Chicago Worlds Fair in 1893. He studied in Paris, before returning to the United States in 1902, where he set up a studio in New York that he made his headquarters for the next 50 years.

Sculptor James Earle Fraser studied in Paris, before returning to the United States in 1902, where he set up a studio in New York that he made his headquarters for the next 50 years.

Among others, Fraser sculpted statues of Alexander Hamilton (D.C.), Thomas Jefferson (Jefferson City, Mo.), Albert Gallatin (D.C.), John Hay (Cleveland), Benjamin Franklin (Philadelphia), Abraham Lincoln (Jersey City, N.J.), Thomas Edison (Dearborn, Mich.), Harvey Firestone (Akron, Ohio), and General George Patton (West Point). His Roosevelt group for the American Museum of Natural History was dedicated in 1940. Fraser is best known, however, for two other works: the Indian Head (Buffalo) nickel in 1913 and his sculpture The End of the Trail, first exhibited at the Panama-Pacific International Exposition in San Francisco in 1915, where it won a gold medal.

The Indian Head nickel was Americas standard five-cent coin between 1913 and 1938. It was preceded by the Liberty Head nickel (1883-1913) and was replaced by the Jefferson nickel, which (somewhat redesigned) still circulates. The Fraser Indian Head nickel was part of a general currency reform undertaken by President Theodore Roosevelt, who engaged his friend Augustus Saint-Gaudens to give our coinage a more modern and more quintessentially American look. This was the same impulse that led TR, when the White House was remodeled in 1902, to insist that the carvings on the stone fireplace mantel in the State Dining Room be changed from lions to the American bison (buffalo).

The Indian Head nickel, designed by Fraser, was introduced in 1913.

The buffalo on the reverse side of the Indian Head nickel (tails) was probably modeled after a bison bull in New Yorks Central Park Zoo named Black Diamond. Black Diamond was the offspring of a bull and cow given to the zoo by the Barnum and Bailey Circus. It is also at least possible that the nickel buffalo was modeled after one of the bulls brought back from the Montana frontier by William Hornaday, the man who did more than anyone else to save the buffalo from extinction, and the first director and one of the founders of the Bronx Zoo. Frasers accounts of the sculpting process varied over time, but he knew the artistic effect he wanted to achieve, and it was identical to the cultural philosophy of Theodore Roosevelt. When I was asked to do a nickel, I felt I wanted to do something totally Americana coin that could not be mistaken for any other countrys coin. It occurred to me that the buffalo, as part of our western background, was 100 percent American, and that our North American Indian fitted into the picture perfectly.

Frasers Indian was a composite. The depiction of the Native American on the obverse face (heads) was based on several of Frasers encounters with Plains Indians. Before the nickel was made I had done several portraits of Indians, among them Iron Tail [an Oglala who performed with Buffalo Bill], Two Moons [a Cheyenne who participated in the Battle of the Little Bighorn], and one or two others, and probably got characteristics from those men in the head on the coins, but my purpose was not to make a portrait but a type. As is often the case in cultural history, a number of different Native Americans later claimed to have been Frasers model. The result is quite beautiful, with perhaps just a touch of probably unintended caricature. Today, Fraser would probably be accused of a mild form of cultural appropriation, though the Sacagawea dollar that circulated during the bicentennial of the Lewis and Clark Expedition (2003-2009) was also partly a composite, and it was also designed by a non-Indian artist.

The End of the Trail is one of the most iconic images of American Indians in our culture. It depicts a Native American man slumped over an exhausted horse standing gingerly at the end of the trail, overlooking, Fraser said, the Pacific Ocean, because American Indians had been driven out of all of their traditional homelands farther and farther west until there was nowhere left for them to go. The Native man is holding a lance which is pointed toward the ground, not in defiant resistance but in defeat. Fraser fashioned the lance so that from a distance it appears to have transfixed the Native man.

Fraser's "The End of the Trail" is considered one of the most iconic images of American Indians in our culture.

Its a great sculpture by a distinguished American artist. I have been drawn to it all of my adult life. You can hardly go through a whole day of traveling through the American West without seeing it on a car decal, a belt buckle, a t-shirt, or a motel sign. Even though I have always loved the image, I have for a long time felt uneasy about it. Created in 1915 not long after the century of the Indian Wars ended at Wounded Knee (Dec. 29, 1890) and with the passage the Dawes Act (Feb. 8, 1887), which parceled out the reservations into small square homesteads, many of them claimed as surplus by white pioneers, The End of the Trail expresses genuine sympathy with the plight of Native Americans. Thats almost everyones first impression of the sculpture. But it represents nobility in defeat, dignity in loss, the end of Indian resistance, and the vanishing Indian, as if once Native American resistance to the white conquest of the continent was over, Indians would simply disappear over the horizon.

This, in fact, is the message of John Gasts famous 1872 painting American Progress, in which the angel Columbia floats over the landscape stringing telegraph wire while the Natives ride off once and for all into the sunset as covered wagons, steamboats, plowmen, and railroads occupy their former hunting grounds. It is also the burden of a number of state seals: white pioneers advancing, Natives receding into the past. Frasers sculpture manages at the same time to be triumphalist for white civilization the conquest of the continent is now complete and yet compassionate. He is well aware of the cost of American civilization.

John Gasts 1872 painting American Progress.

But heres what I consider to be the problem with Frasers famous sculpture. During the conquest period, from 1607 to 1900, the European-derived white Americans were so threatened by the idea of Native American sovereignty and resistance, so determined to take the continent by whatever means necessary, no matter how ruthless, that they did not have the luxury of exhibiting much respect or sympathy for the peoples they were displacing. Native Americans were denigrated and demonized, called savages, red devils, prairie n.rs, and worse.

Even in the 1880s, the most famous re-enactment in Buffalo Bills Wild West was the Indian attack on the settlers cabin, finally repelled, of course, and the virtue of Victorian wives and daughters preserved by the white cavalry. Frontier newspapers wrote front page editorials dripping with unguarded racism, some of which unapologetically called for the actual extermination of American Indians.

It is a sad but telling irony that the most popular genre of frontier encounters literature was the captivity narrative, in which a white woman is kidnapped by marauding savages and handed around to lusty warriors to suffer a fate worse than death at their hands. Rather than a narrative, say, in which Native peoples are minding their own business on their ancestral lands when an armed white militia group arrives to wipe out men, women, and children in a dawn raid.

By the time Theodore Roosevelt became the 26th president of the United States, the Indian Wars, were over many of them clearly fueled by the leftover testosterone and white male rage of the Civil War (on both sides). American Indians had been pacified, thrust onto reservations, many of which were incapable of supporting the resident population, forced to take up till agriculture on barren lands, their children carried off by force to faraway boarding schools where they were taught to be red Americans. Finally, victory in hand, it was possible for white colonialist civilization to step back and take a deep breath. The threat was over. Crazy Horse (Oglala) was dead. Sitting Bull (Hunkpapa) was dead. Red Cloud (Lakota) was disarmed (in every sense of the term). Geronimo (Apache) and Chief Joseph (Nez Perce) were sufficiently tamed to be pressed into marching in Roosevelts March 1905 Inaugural Parade, like conquered Gauls in one of Julius Caesars Roman triumphs.

Now it was possible to pull back a little on the steam juggernaut of Americas Manifest Destiny and find some sympathy, in defeat, for the Native peoples the United States had spent the previous 100-plus years dispossessing, fighting, cheating, and offering one lying promise after the next. How many times had white negotiators in the Black Hills or the Wallowa Valley in Washington said, Give us this much land and we promise we will never be back for more?

The narrative of the vanishing Indian has a long pedigree in American culture. In the 1830s, American ethnographer and artist George Catlin and the German prince Maximilian of Neuwied traveled on separate missions to the northern Great Plains to capture Native American culture before it was too late. Catlins paintings and essays, together with the magnificent watercolors of Maximilians artist Karl Bodmer, provided the world an indelible portrait of Native American life just when the fur trade was beginning to destabilize Upper Missouri cultures dramatically.

James Earle Fraser in his studio with a clay model of the "The End of the Trail" sculpture, ca. 1910. (Special Collections Research Center, Syracuse University Libraries, N.Y.)

Half a century later, the Seattle-based photographer Edward S. Curtis undertook a 30-year project to photograph Native Americans of the trans-Mississippi West in their native clothing and in as close to a pre-white cultural landscape as was still possible, again, to get it all down before it was too late. Frasers gorgeous The End of the Trail is perhaps the greatest certainly the most iconic rendition of the vanishing Indian genre. It spoke powerfully to the American public in 1915 and it still speaks to the world in 2020.

But its message is problematic. First, there is the hypocrisy of just starting to celebrate the American Indian when you have finished the work of vanquishing him. Fraser would not have received acclaim if he had presented the sculpture in 1870 or even 1890, while the mad conquest was still unfinished. Second, as any Native American cultural representative will tell you, Indians didnt vanish after all. They morphed, accommodated, adjusted, partially assimilated, ducked below the radar, regrouped, resisted, and above all survived. They are still among us, though you and I might not always recognize them in their 21st-century clothing, working side by side with their white and Black counterparts all across the United States and Canada.

The End of the Trail may mark the end of one phase (one trail) of the history of indigenous Americans, but it did not extinguish them biologically or culturally, in spite of the best efforts of the 18th- and 19th-century conquerors. As Mark Twain put it about newspaper reports that he had died, reports of my death are greatly exaggerated. Reports of the final vanishing of Native Americans have always proved to be more pessimistic than accurate. In fact, one of the single most remarkable, even stunning, facts of American history is the resilience and now resurgence of Native American culture language, craft work, agriculture, religious observance, and cultural pride.

What links The End of the Trail with the TR statue group at the Museum of Natural History is an understanding, even if a somewhat melancholic one in the case of the vanishing Indian, that white Europeans and Americans were the dominant race of the world, destined to bring civilization to all the benighted indigenous people of the planet, whether in South Africa, Rhodesia, New Zealand, and the American West, whether they liked it or not, and at the end of the Gatling Gun if necessary.

It was widely thought in Roosevelts era that Native Americans could not co-exist with white civilization, at least not in any recognizable form. Frasers The End of the Trail evokes sympathy not righteousness, a post-conquest respect rather than a guilty call for attempting to undo what Helen Hunt Jackson called a century of dishonor. It may have been necessary to be ruthless in bringing about the Europeanization of North America and other waste places, as Roosevelt termed them, but it was then thought to be the burden and destiny of Anglo-Europeans and Teutonic peoples to extend the blessings of civilization to the far corners of the earth. This, certainly, was Roosevelts view and he was, in his four-volume Winning of the West, entirely unapologetic about it. The most ultimately righteous of all wars is a war with savages, he wrote. American and Indian, Boer and Zulu, Cossack and Tartar, New Zealander and Maori in each caser the victor, horrible though many of his deeds are, has laid deep the foundations for the future greatness of a mighty people.

If we want to understand the current cultural moment, we must try to understand it in the troubled context of American history.

I believe it would be a crime against art and human creativity to destroy any of James Earle Frasers sculptures. All of his work is characterized by soulfulness and generosity of spirit. Even the two Natives in the Roosevelt statue group in New York are depicted with a kind of sensual dignity. Separated from TR on horseback, they would perhaps now be regarded as beautiful and non-controversial, although the fact that the African is depicted as a gun bearer signifies his subordinate status.

Frasers art should not be lumped in with a hastily rendered statue of Stonewall Jackson thrown up in the middle of the Civil Rights Movement in the deep south to intimidate African Americans and maintain the apartheid of Jim Crow America. No fair person can look at Frasers sculpture and believe he was a deliberate racist. He was not one of those whites Martin Luther King denounced in August 1963, as vicious racists . . . lips dripping with the words of interposition and nullification.

In fact, the ambivalences of Fraser and the ambiguities of his sculpture are precisely what we prize in great art. Who has ever written a definitive essay on "Hamlet" or explicated Joyces Ulysses to the satisfaction of the rest of us, or figured out precisely what is going on in an Emily Dickinson or Langston Hughes poem? Our best strategy I know I write as a white male of privilege is to remove such statues as now intensely irritate, offend, or hurt, to contextualize the ones that are in any significant way problematic, and then to place at least the best of the offensive statues in obscure rooms in our museums with plenty of critical interpretation. Iconoclasm is always a gross form of art criticism and it paints our rich, nuanced, often tragic history with a very broad and sometimes unjust brush.

If James Earle Fraser were alive today, I doubt that he would fashion the TR sculpture group as he did. He would not presume to appropriate Native American iconography to form a composite Indian for the nickel, and he would find it conceptually impossible to believe that Native Americans, some of whom have been governors and U.S. Senators, presidents of universities, great athletes, internationally revered hoop dancers and flutists, and extraordinary doctors, lawyers, CEOs, and writers, were a vanishing race.

That was then.

For more of Clay Jenkinson's views on American history and the humanities, listen to his weekly nationally syndicated public radio program and podcast The Thomas Jefferson Hour. Clay's most recent book, Bring Out Your Dead: The Literature and History of Pandemics is available at Amazon.com.

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Intel Editorial: The Pandemic Drives New Era of Tech Collaboration – Global Banking And Finance Review

The following is an opinion editorial by Rick Echevarria of Intel Corporation.

One hundred days ago, our CEO, Bob Swan, announced the Intel Pandemic Response Technology Initiative. Intel would invest $50 million to combat COVID-19 in ways we knew best: using technology to study and help with the diagnosis of the coronavirus, helping disrupted educators and students, and supporting innovative new ideas and projects.

Ive had the privilege of leading this initiative and seeing an extraordinarily committed group of Intel employees, customers and partners mobilize. In just over three months they have made possible new and creative uses for our technology to address a range of challenges. Weve come a long way, learned a lot and still have much to do. On behalf of this team at 100 days in I wanted to share some of that journey.

More: Intel Response to COVID-19 Crisis (Press Kit) | Intels PRTI at 100 Days: In Los Angeles, Online Classes that Inspire

So far, Intel has partnered with over 100 organizations on close to 200 projects totaling more than $30 million in contributions from the original pandemic response to first early steps toward recovery. In those early days, we provided ventilator manufacturers with vital parts. We assisted with the creation of virtual intensive care units.

Today, were providing technology and educational content for students who might otherwise be left behind. Were aiding businesses as they take the first steps to re-open safely. And were exploring ways Intel technology and our financial support can be used in the search for diagnoses, treatments and vaccines.

Our role through the pandemic points out undeniable lessons: Technology used to its potential can save lives and change lives. No one can solve these problems alone. And we will never thrive as we once did if we dont work with our customers and our communities to make our world better after we recover.

Three examples show how far weve come.

As weve moved through the lifecycle of pandemic response, its obvious the coronavirus has changed society, industry and Intel. Historic calls for change (the end to acts of racism, inequity and social injustice) in COVID-19s shadow illustrate how important the coming few months will be for all of us in the U.S. and around the world. Collectively, its led us at Intel to recognize several vital lessons.

Technology and its creative use are needed more than ever: Four months ago, Intel CEO Bob Swan wrote to our customers: You provide vital services, tools and infrastructure to millions of people who are directly struggling with this virus Day in and day out, it has proven true. Inside Intel and with our customers, weve broken down silos to move more quickly than ever. Newly discovered sources of technology value, like Providences care at a distance, prove to be life-changing as patients and care providers grow comfortable with them. Weve thought creatively and pulled together customers to provide services that are saving lives, educating students and keeping our community infrastructure solid.

Data collaboration and sharing have never been more important: Solving the challenges brought to the world by the coronavirus requires researchers worldwide to work together. The whole world has become a peer community. There is much we dont know about the coronavirus, but with the help of federated learning, researchers are able to privately share patient data as they collaborate to create a vaccine or treatment program. They can access a rich world of data to make better decisions and follow groundbreaking clues, all without breaching privacy laws. Our technology to effectively manage, share and collaborate using important data sets has never been as significant as when researchers are chasing a deadly virus.

Better health will go hand in hand with recovering economies: Peoples health will be critical to the worlds economic recovery, just as the economic recovery will be key to everyones health. Going back to doing things the way we did them before wont carry over after the coronavirus is solved. I keep going back to it, but telehealth is a great example. To best realize its benefits, we need to recognize its success and acceptance among people seeking physician guidance. Only that will allow it to thrive.

As a company, we have learned to operate with more empathy, agility and velocity. We look at our products not for what we know they can do, but for what they might be able to do in a changed world. Outside of our walls, we have come together in new ways with customers, partners and the community and weve seen what a difference working together can make when we all think and act creatively.

We wont forget these lessons. They will shape our approach, as we press forward with our goals for the next decade.

Life will be different for everyone around the world after the coronavirus is history. Doctors and patients will communicate from a greater distance. Educators will find lessons in distance learning to make online classes more effective and meaningful. Cures for many more diseases will come from the private, safe and efficient sharing of data.

Our Pandemic Response Technology Initiative cant solve all of the challenges were facing, but what we learn and what we teach others after this event will create a strong foundation for the future. Its inspiring to see how our technology and that of the broader high-tech industry will make enriching lives (even in a world as challenged as it is today) possible.

Rick Echevarria is vice president in the Sales, Marketing and Communications Group and general manager of the Intel Olympic Program at Intel Corporation. He leads Intels Pandemic Response Technology Initiative.

About Intel

Intel (Nasdaq: INTC) is an industry leader, creating world-changing technology that enables global progress and enriches lives. Inspired by Moores Law, we continuously work to advance the design and manufacturing of semiconductors to help address our customers greatest challenges. By embedding intelligence in the cloud, network, edge and every kind of computing device, we unleash the potential of data to transform business and society for the better. To learn more about Intels innovations, go to newsroom.intel.com and intel.com.

Intel Corporation. Intel, the Intel logo and other Intel marks are trademarks of Intel Corporation or its subsidiaries. Other names and brands may be claimed as the property of others.

Laurie Smith DeJong

503-313-6891

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Intel Editorial: The Pandemic Drives New Era of Tech Collaboration - Global Banking And Finance Review

Coronavirus Update From City of Las Vegas

For more information about the city's reopening plans, please visit http://www.lasvegasnevada.gov/welcomeback.

Gov. Sisolak announces mandatory face covering policy in public

Bars, pubs, taverns, distilleries, breweries and wineries that dont serve food in Nevada counties listed below must close effective July 10 at 11:59 p.m.These counties are considered to be Elevated Disease Transmission counties. Bar tops & bar areas within restaurants and food establishments in these counties must also close to customers. They will be evaluated again in two weeks on Friday, July 24.

Elevated Disease Transmission Counties:Clark County, NevadaElko CountyHumboldt CountyLander CountyLyon CountyNye County, NevadaWashoe County, Nevada

Additionally, statewide, all restaurants and food establishments - pubs, breweries, distilleries, wineries - which are licensed to serve food, must not seat parties larger than 6 people, indoors and outdoors. Food establishments should encourage outdoor dining.

Visitors

There are currently not travel restrictions in place but we recommend staying tuned to the latest news from our governor's office here: https://nvhealthresponse.nv.gov/info/travelers-visitors/

Getting Tested

Here is a list of testing locations:https://nvhealthresponse.nv.gov/find-covid-19-testing-in-nevada/

If you are positive for COVID-19, you will receive a text message from 844-990-0029 with additional information. The Health District asks that you answer the call so we can prevent more infections in our community.

The city has made adjustments to its services in response to the coronavirus outbreak.The public can call 702-229-CARE (2273) from 7 a.m. to 7 p.m. Monday through Friday. The line will give callers automated options on weekends.

The below list will be regularly updated.

Municipal Court

The city of Las Vegas and the Las Vegas Municipal Court's top priority ishealth and safety of our staff and visitors.We are taking precautions due to COVID-19, including extending continuance to those who are not comfortable visiting the Regional Justice Center, who may be exhibiting potential signs of illnessor who are in a high-risk category.To avoid high-risk crowding, the traffic windowsare closed until further notice.If you need to make apayment, or reschedule your court date and cannot do so on our website, please call 702-229-5257.

Effective March 16, 2020, Municipal Court will accept court filings and continue to operate managing cases bytheparameters set forthin this order.

Sewer Services

The citywill waive sewer bill late fees and property liens normally filed on delinquent sewer bills until 30 days after the current city emergency declaration ends. Those who are employed or not suffering financial hardship are encouraged to keep current on their sewer bills.

City of Las Vegas sewer bills may be paid online at https://www.lasvegasnevada.gov/sewer. Those with questions regarding sewer bills may email sewerservices@lasvegasnevada.govor call 702-229-1289.

Assistance

Small Business Grants

A new Business Preparedness Grant created by the city of Las Vegas using $2 million in CARES Act fundsthrough July 31, or until sufficient applications have been received. Since we had many businesses apply during the first grant program, we will be giving priority and reviewing those applications for eligibility.There is no need to re-apply. Business owners will be required to sign an affidavit. Submissions will not be considered without it. For more information visit lasvegasnevada.gov/reopeninggrant.

Housing Assistance

Clark County has launchedits Cares Housing Assistance Program . The program is available to all residents of Clark County (which includes city of Las Vegas residents). The program serves residents who have suffered substantial financial hardship and now lack sufficient income or resources available to pay their housing costs because of the COVID-19 emergency or the response to that emergency. For more information visit https://helphopehome.org/clark-county-cares-housing-assistance-program/

The state of Nevada is also providing rental assistance:https://housing.nv.gov/

Moratorium On Evictions Through Duration OfState Of Emergency

Governor Steve Sisolak signed an emergency directive putting a moratorium on all residential and commercial evictions in the State of Nevada through the duration of the State of Emergency. This directive does not constitute free rent or mortgage. For more information, visit https://nvhealthresponse.nv.gov/wp-content/uploads/2020/03/Gov.-Sisolak-Guidance-Directive-008-Evictions-Updated-on-3-30.pdf

On June 25, Governor Sisolak signed Emergency Directive 025 will gradually lift the moratorium on evictions.He alsostronglyurged landlords and tenants to work togetherand collaborateon repayment plans.

Directive 025lifts the moratorium on evictions and foreclosures imposed by Directive 008 in phases by allowing residential evictions and foreclosures to resume in full on September 1fornon-payment of rents and no cause evictions.Late fees or penalties for non-payment of rent or mortgage payments may not be charged retroactively.

The directivereinstates residential summary evictionsand unlawful detainer actionsprior to September 1forcertain causes other than non-payment of rent.These caused based actions do not include non-payment of rent, but include holdover tenants, tenants at will, waste, unlawful business, nuisance, violations of controlled substance laws, and violations of lease conditions other than non-payment of rent.

For commercial tenancies and mortgages, landlords and lenders can again charge late fees, initiate lockouts, or start eviction actions for non-payment of rent or foreclosure proceedings beginning July 1.

The Governorstrongly encouragesthat all landlords and tenantsworktogether on repayment plans.The Nevada Attorney Generals Officehascreateda template Lease AddendumandPromissory Note toassist andencourage landlords to work with tenants on a repayment planto keep people in their residencesand to avoid overwhelming the courts.

This voluntary document is intended to help landlords receive delinquent rental amounts while helping keep tenants in their homes or places of businessunder a payment plan for back due rents that they can afford.

Additionally, the Nevada State Treasurers Office is workingon coordinatingastatewiderentalassistanceprogram to help residential and commercialtenants, withthegoal of having theresidentialprogram up and running by mid-Julyand the commercial program shortly thereafter.

Other Help

NV Energy, Southwest Gasand the Las Vegas Valley Water District are willing to work with customers right now.

Republic Services remains fully operational in Southern Nevada with no changes to residential collection service at this time. Bulk pickups are continuing as scheduled. For more information, visit http://www.republicservicesvegas.com.

Three Square Food Bank has emergency food centers at 15 schools and 43 other locations for anyone who needs help.Three Square is offering grocery delivery for those in need that are 60+. Visithttp://threesquare.org/helpor call 702-765-4030 to see if you qualify.

Lost Pet ReunificationFees Waived

To help families who might be struggling, fees will bewaived for when the owner picks up their lost petas long asownership can be verified and required documentation provided.This applies to animals that arepicked up by city of Las Vegas Animal Control officers and taken to the Animal Foundation. Call the shelter at 702-955-5932 for more information.

Have You Been Exposed?

COVID-19 is a respiratory disease caused by a new virus called SARS-CoV-2. The most common symptoms of the disease are fever, persistent coughand shortness of breath. Most people with COVID-19 will have a mild disease but some people will get sicker and may need to be hospitalized.Please click here if you think you have been exposed to or are developing potential symptoms.

Unemployment

Governor Steve Sisolak instructed the Nevada Department of Employment, Training and Rehabilitation (DETR), Employment Security Division to waive the work search requirement and the 7-day wait period for approved unemployment insurance benefits.

To file for unemployment in the State of Nevada, please use the online application available 24/7 athttp://ui.nv.gov/css.html. People unable to file online may file via telephone by calling a UI Claims Call Center between 8 a.m. and 8 p.m., Monday through Friday. Northern UI Call Center: (775) 684-0350; Southern UI Call Center: (702) 486-0350; Rural areas & Out-of-State: (888) 890-8211.

Online users can refer to the resources listed onui.nv.govand the updatedNV Unemployment Insurance (UI) Frequently Asked Questions (FAQs) document athttps://detr.nv.gov/Page/COVID-19_(Coronavirus)_Information_for_Claimants_and_Employers.

ThePUA program is one provision under the federal CARES Act and is designed to offer unemployment benefits to independent contractors and others historically unable to qualify for traditional unemployment insurance benefits:www.employnv.gov.The new filing system is independent of the traditional Unemployment Insurance (UI) system and will facilitate a streamlined method for the public to file for PUA benefits. Claimants will have a dedicated call center for all PUA related questions with a new phone number: 1-800-603-9681.

The following individuals may be eligible for PUA:

Claimants must also be able and available for work as defined in state law, must have prior earnings in Nevada or a job offer to work in Nevada and must not be eligible for any UI benefits, including regular UI, Pandemic Emergency Unemployment Compensation, and State Extended Benefits.

We want your stories about how the Las Vegas community is coming together to help each other. Fill out this form: https://cityoflasvegas.link/InItTogetherSNV,Big or small, if it makes you smile, we'd like to know about it!

Donate blood. There is a dire need in our community right now.Visit http://RedCrossBlood.orgorhttps://www.vitalant.orgtomake an appointment.

Nextdoor, the private social network for neighborhoods, has a help map where you can ask for help or offer help to your neighbors.

The city of Las Vegas is coordinating with Clark County andthe Southern Nevada Health Districtto address health risks posed by the pandemic. Standard precautions already in place at the Courtyard Homeless Resource Centerincludefrequent cleaning and disinfecting of surfaces, making hand-washing stations availableand providing alcohol-based hand sanitizers.Anyone who needs help can visit lasvegasnevda.gov/homeless.

Isolation-Quarantine Complex

The joint Clark County-City of Las VegasISO-Q(Isolation and Quarantine) Complex at Cashman Center began taking patients April 13, and is scheduled to close June 30.The complex served as a safe place that 234 individuals experiencing homelessness used to quarantine, ensure that others were not infected and in some cases recover from COVID-19.

Complex staff also oversaw the administering of 846 COVID-19 tests, and helped a total of 20 COVID-19 positive individuals recover. In addition, more than 17,000 health screenings have occurred at the Courtyard Homeless Resource Center since April 13.

Clark County and the city of Las Vegasjointly fundedthe facility. In addition, The Mayor's Fund for Las Vegas LIFE assistedwith processing donations for the complex.

Is Our Water Safe?

COVID-19 is a respiratory illness, like the flu, which is spread person to personthere is no indication that transmission can occur via drinking water supplies.

Southern Nevadas drinking water is treated using a combination of ozonation, filtration and chlorination, which are on the leading edge of water treatment processes and effective at removing contaminants from water. To ensure your water meets or surpasses drinking water standards, we also monitor water quality around the valley 24 hours a day, 365 days a year.

The Southern Nevada Water Authority & Las Vegas Valley Water District do not anticipate any current scenario that would interrupt water availability to our community.

We are committed to ensuring your water quality, reliability and security because we know you depend upon it every day.

Rumor Control

For a full list from FEMA, visit https://www.fema.gov/coronavirus-rumor-control.

Is 5G Cell Phone Technology Linked To The Cause Of Coronavirus?

A worldwide online conspiracy theory has attempted to link 5G cell phone technology as being one of the causes of the coronavirus. Many cell towers outside of the U.S. have been set on fire as a result;5G technology does NOT cause coronavirus.

I Got A Call, Text, Or Email Saying I Could Get Financial Help. Is It Legitimate?

There have been reports that scammers are pretending to be the government, contacting people by robocall, text message, email and other outreach. These scammers say they can get people financial help during the COVID-19 pandemic, and then ask for money or personal information, like your Social Security, bank account or credit card number. This is aSCAM.

Dont trust anyone who offers financial help and then asks for money or personal information. Federal and local disaster workers do not solicit or accept money. The Department of Homeland Security, FEMA, U.S. Health and Human Services and the Centers for Disease Control staff never charge for disaster assistance.

The Federal Trade Commissionscams pagehas tips to help youavoid scamsonline, on thephone, by text andthrough email. If you see a scam, please report it to the Federal Trade Commission:ftc.gov/complaint.

Listen to the city coronavirus podcast update

Watch the KCLV coronavirus video update.

Follow the Health District on Twitter.Subscribe to their tweets by clicking on the bell on their profile here.

Follow the Health District on Facebook.

Official information about travel and major events via theLVCVA

Official updates from CCSD

Official info from the CDC

Or subscribe to the weekly CDC newsletter.

If you have been victimized by any crime related to the COVID-19 pandemic, please report your experience to the Attorney Generals Office (ag.nv.gov/Complaints/File_Complaint/) and the National Center for Disaster Fraud (NCDF) hotline at 1-866-720-5721 or by e-mailing the NCDF atdisaster@leo.gov. In your email, please provide the following information:

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Coronavirus Update From City of Las Vegas

Las Vegas Vacation Packages from $134 – Search Flight …

The best way to enjoy Las Vegas, saving time and money, is with a vacation package. By bundling together hotels and flights, you will often be able to take advantage of preferential rates, as opposed to standard single rates when booking separately. You will also save time matching hotel availability to your flights. If flexibility isnt your priority, Las Vegas vacation packages could leave you more money to spend in the city itself, rather than on getting there.

Booking a Las Vegas flight and hotel package is an efficient way to save on stress and cash. For the best deals and rooms, its advisable to search for Las Vegas vacation packages during quieter periods. Traveling during the week is generally more affordable than at weekends, and by booking earlier you can help avoid higher rates. The July-August Monsoon season is a good time to find Las Vegas travel deals, as most travelers opt to visit during spring and fall when the weather is hotter and dryer. Its also a good time to get away from the concrete and visit the surrounding valleys, mountains and national parks in cooler weather.

Whilst searching for Las Vegas travel deals, be sure to check out seasonal activities. Most crowd-pulling events such as the NASCAR race, the Super Bowl, and the Rodeo happen during fall and winter as well as major conventions such as the Consumer Electronics Show and the Magic International.

The Aria Resort and Casino is one of the classiest hotels on the Las Vegas strip, offering private cabana rental alongside a range of first-class, dedicated amenities to make your Las Vegas getaway feel special. The resort is just a 10-minute drive from McCarran International, and offers a 24-hour taxi and limo booking service. If you book a Sky Suite with the hotel, luxury transfer to and from the airport is included.

The Venetian Resort Hotel is a luxurious, whimsical Las Vegas creation. Housed in a sprawling Italianate palazzo, it boasts an on-site grand canal complete with gondolas, renaissance mall, spacious, eco-friendly suites and 10 outdoor pools. The hotel is just 12 minutes by car or taxi from the airport, and it offers a wide range of transport options, from a taxi booking service to a Grazie shuttle service (free for Gold and Platinum members), running every half hour between 6.am and 6.30pm.

Marriots Grand Chateau, 15-minutes walk from the strip, boasts spacious family rooms, free valet parking, kids activity rooms and a birds-eye view of central Las Vegas. Just a ten-minute drive from the airport, head north onto McCarran Airport Connector, carry on to Swenson Street, then left onto E Harmon Ave. The Chateau offers free valet parking.

The Mandarin Oriental offers cozy family rooms and a range of child-oriented services, from childrens afternoon tea to the arrangement of certified babysitters, to ensure a stress-free stay for the whole family. The hotel is around a ten-minute drive by cab or car from the airport and is located right on The Strip.

The Desert Rose Resort, just 2 blocks from the southern part of the Strip, is a great choice for couples on a budget. It boasts a range of contemporary condominium suites with private patios or balconies. As it doesnt host on-site bars or clubs, its ideal for those looking for something quieter. Just seven minutes from the airport by car, head north onto McCarran Airport Connector then left onto E. Tropicana Ave. After 1.6 miles, turn left onto Duke Ellington Way the resort is on the right.

The MGM Grand attracts some of the worlds most famous acts to its numerous nightclubs and showrooms. With pool complexes, a range of signature bars and restaurants, and generously-sized suites, its an ideal honeymoon resort. The resort offers tax assistance and features on shuttle service routes to and from the airport (just 7 minutes away, though usually longer via shuttle). If driving from McCarran International, head north onto McCarran Airport Connector and left onto E. Tropicana Ave., then right onto Audrie St. and left towards the resort entrance.

The Wynne Las Vegas is a dazzling luxurious resort, featuring a full casino, dozens of boutiques and matchlessly designed amenities. The hotel doesnt offer a free shuttle service, but is located directly on the Strip, and is easily reachable (around 12 minutes) from McCarran International via cab or hired car.

The Four Seasons in Mandalay Bay offers glorious views of the surrounding desert mountains from chic, Art-Deco suites. Alongside stellar on-site restaurants, guests can enjoy tailored treatments in the Forbes Five Star Spa. Limo, taxi and rental car services are available for airport transfers (around 12 minutes away) and beyond.

The Mardi Gras Hotel and Casino is located 5 minutes from the Monorail and offers free shuttles to the Strip and airport transfers (between 7am and 10pm). It also offers free service level parking and a friendly full-service bar and restaurant. From the airport, simply head north on Paradise Road for 2.3 miles. The hotel is on the right.

The Circus Circus Hotel, Casino, and Theme Park is just 5 minutes drive from the Convention Center and offers free entertainment nightly. The hotel is just 8 minutes away from the airport by cab, or half an hour way via line 108 bus.

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Las Vegas Strip: The 15 attractions you must see | CNN Travel

Las Vegas (CNN) Las Vegas Boulevard -- the world-famous Las Vegas Strip -- is the central artery of Sin City and the main line to a majority of the city's best sights, gambling, food and fun.

With neon signs and dancing fountains along an eight-mile stretch of awesome, the Strip delivers sensory overload.

It's best to start at the beginning, at the southern end of the Strip. From south to north, here are 15 of our favorite attractions on one of the most famous roads in the world.

1. 'Welcome to Fabulous Las Vegas, Nevada' sign

Brian Jones/Las Vegas News Bureau

The iconic "Welcome to Fabulous Las Vegas, Nevada" sign serves as Sin City's unofficial welcome mat.

This neon beacon has greeted visitors at the south end of Las Vegas Boulevard since 1959, when commercial artist and prolific sign designer Betty Willis designed it as a gift to the city. Because Willis never trademarked her work, merchandising companies have been able to replicate it on t-shirts, mugs and other tchotchkes.

The sign was added to the National Register of Historic Places in 2009, and it's one of the most popular selfie spots in town. It also served as the site of a makeshift memorial after the mass shooting at a country music concert in October 2017.

"Welcome to Fabulous Las Vegas, Nevada," sign, Las Vegas Boulevard, South. Las Vegas, NV 89101.

2. Luxor Hotel & Casino

This 1990s-built pyramid isn't one of the seven wonders of the world, but it stands out in a town where copycatting New York, Paris, Venice and other iconic destinations certainly is a compliment.

Inside, guests ride inclinators instead of elevators to their rooms, and people-movers ascend and descend at 39-degree angles along the corners of the pyramid, creating a rocking sensation that makes riders feel like they're on a boat.

3. The Park

Francis and Francis/Courtesy MGM

One of the newest additions to Sin City, this $100 million urban oasis between the New York-New York and Park MGM (the soon-to-be-renamed Monte Carlo) hotels stretches from Las Vegas Boulevard back to T-Mobile Arena.

Along the way, brick walkways wind past the Las Vegas outpost of Shake Shack and other open-air restaurants, a walk-through water feature that evokes parting the Red Sea and "Bliss Dance," a 40-foot-tall statue of a dancing woman. The area is hopping before home games for the NHL's Golden Knights, the first pro sports team in Vegas history.

4. Public art at City Center

While Las Vegas isn't known for its art scene, MGM Resorts has invested $40 million over the last 10 years in public art at the 67-acre City Center complex.

Notables include Maya Lin's "Silver River," which hangs behind the registration desk at Aria Las Vegas and depicts the course of the Colorado River; and Glacia, a piece on the ground floor of The Shops at Crystals composed of 15-foot-tall ice columns rising anew each morning and melting in different patterns throughout the day.

A third piece, named "Big Edge," comprises more than 200 kayaks, canoes and other water vessels.

City Center, Las Vegas, NV 89109; between the Monte Carlo Las Vegas Resort & Casino and Harmon Avenue.

5. Fountains of Bellagio

Water that dances like ballerinas. Cannons that shoot water hundreds of feet in the air. Yes, the fountains that span the artificial lake in front of Bellagio Las Vegas have become one of the most iconic Vegas sights. It's no wonder this is where the characters from the 2001 version of "Ocean's 11" met to celebrate their big heist.

The spectacle, designed by a company poetically named Wet, opened with the property in 1998 and today comprises more than 1,000 fountains in all, some shooting spray more than 450 feet into the air. The fountains go off weekdays every 30 minutes between 3 p.m. and 8 p.m., and every 15 minutes between 8 p.m. and midnight. They are even more frequent on weekends.

Unless you've got a bird's eye view from a balcony suite at The Cosmopolitan, arrive early to secure a prime standing-room only spot along the Strip.

6. Fall of Atlantis show

Drama is in full effect at this free animatronic spectacle inside the Forum Shops at Caesars Palace. The 11-minute show tells the story of the Lost City of Atlantis, and what happens when the ailing King Atlas must decide which of his children should rule.

Audiences are treated to video screen supplements, fireballs, a 20-foot winged dragon and props by set designers who worked on "Thor" and "Pirates of the Caribbean." There are even fish tanks with real, live fish. The show debuted in 1997 and was updated in 2013. Shows start every hour between 11 a.m. and 10 p.m.

7. LINQ Promenade

In between, the Promenade is home to the Strip's only In-N-Out Burger franchise, a West-Coast outpost for the bowling alley/concert venue Brooklyn Bowl and a Beverly Hills-based Sprinkles bakery that sells cupcakes from an ATM. A zipline is expected to open later this year.

8. Wildlife Habitat at Flamingo Las Vegas

This zoo-like oasis in the courtyard of the Flamingo Las Vegas is home to more than 60 exotic birds (including Chilean flamingoes, of course), 20 turtles and 300 fish.

The free attraction opened in 1995, and it's a great place to escape from the hubbub of the Strip and the nearby LINQ Promenade. To see the animals in their most active states, swing by for one of the twice-daily feedings, held in a section dubbed "Pelican Island" at 8:30 a.m. and 2 p.m.

9. The Mirage Volcano

Ethan Miller/Getty Images for MGM Mirage

Fireballs, water cannons and booming percussion riffs highlight the free "eruptions" at the volcano that fronts The Mirage along Las Vegas Boulevard.

The soundtrack is a collaboration between Mickey Hart, former drummer for The Grateful Dead, and Zakir Hussain, an Indian musician who is a master of a drum called the tabla.

The volcano dates back to the hotel's opening in 1989. It was updated with new beats in 2008. Pyrotechnics go off Sunday-Thursday at 7 p.m. and 8 p.m., with an additional show on Fridays and Saturdays at 9 p.m.

10. The Venetian's canals

Baritones boom out Italian love songs as they paddle past. Couples canoodle in gondolas as they glide by. You can't get more Venetian than this outside of Italy.

So when Sands Corp. CEO Sheldon G. Adelson built The Venetian, he spared no expense to replicate the iconic waterways. Gondola rides are available in two spots: outdoors in a canal that runs along Las Vegas Boulevard, and indoors along the 285,000-gallon Grand Canal, which passes beneath bridges and past piazza cafes.

Most of the stripe-shirted gondoliers sing upon request, and photo packages are available to capture the moment for posterity.

11. Adventuredome

The main attraction at family-friendly Circus Circus Hotel & Casino is the Adventuredome-a glass-enclosed big-top with five acres of diversions. Rides include two roller coasters (including one that drops at 1.5 vertical-G), a half-dozen spinning rides, virtual reality experiences and a carousel.

The Adventuredome also sports a carnival midway with more than 40 games, an arcade, mini-golf, bowling and clown shows. The best value is a per-person discounted all-day wristband.

12. Gold & Silver Pawn Shop

Reality television fans flock to this working pawn shop, which has been the backdrop for the History channel's television series, "Pawn Stars," since 2009.

Time it right and you might even catch film crews capturing Rick or Corey Harrison examining items or yelling at customers. The queue of people outside the shop is a telltale sign that cameras are rolling. Over the years the retail floor has grown to include branded souvenirs, a sure sign of television success.

13. Fremont Street Experience

Fremont Street Experience

Fremont Street Experience is the heart of downtown Vegas; a five-block pedestrian-only entertainment district with everything from the SlotZilla, the world's largest slot machine, to a zipline. Actually, the zipline starts inside the slot machine.

There's also a zombie-themed maze and live music every night. Looking down on all the mayhem is Viva Vision, a 1,500-foot-long video screen with 12.5 million LED lights and a booming sound system.

The best way to take it all in? Slowly, with a yard-long frozen margarita in hand.

14. Downtown Container Park

More than 40 repurposed shipping containers just east of Las Vegas Boulevard have been turned into a popular spot for shopping, dining and nightlife.

Don't miss the craft cocktails at the whiskey-heavy Oak & Ivy, and be sure to take the 33-foot-long slide down from the three-story "treehouse" in the center play area.

The giant fire-breathing praying mantis sculpture out front was apparently too cool to burn. (It was created for the Burning Man festival by aerospace engineer and artist Kirk Jellum.)

15. The Neon Museum

The Hard Rock Cafe sign was dismantled in 2017. It now has 1,500 new bulbs, 4,000 feet of neon tubing, and a new permanent home at the Neon Museum in Las Vegas.

If neon could talk, it likely would be able to regale every visitor with colorful stories about Rat Pack-era Las Vegas.

Actually, the more than 200 neon signs sit in a lot called the "Boneyard" do tell the history of Las Vegas at this one-of-a-kind museum downtown.

Visitors can explore this collection only through an hour-long guided tour.

Among the highlights: Old signs from the fronts of Caesars Palace, as well as the old Stardust. All guests enter the facility through the circa-1961 mid-century modern visitor center, which actually is the former lobby for the La Concha motel. Tours are best at night, when 11 signs light up.

In February, the museum opened an augmented reality experience that incorporates high-tech projectors and Rat Pack-era music to reanimate many other iconic signs.

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Las Vegas event to address COVID-19 response and Vegas economy – KTNV Las Vegas

The Las Vegas Global Economic Alliance (LVGEA) will be holding an event on July 28 for the 40th annual Vegas Perspective, taking place for the first time virtually.

The virtual meeting will be from 9 to 10:30 a.m.

Perspective is the regions premier source for community and economic development information, analysis, and forecasting.

The event will include speakers to discuss COVID-19 and the impact the economy will have moving forward.

Speakers include Jim Murren, chair of the Nevada COVID-19 Response, Relief and Recovery Task Force and, previously, Chairman and CEO of MGM Resorts International, as well as Jeremy Aguero, principal analyst at Applied Analysis. Each of their presentations will be followed by a Q&A portion moderated by Derrick Hill, LVGEA 50 Chairman and VP of Cox Business and Hospitality Network, and Shannon Petersen, Executive Vice President/Corporate Banking Manager, Nevada State Bank.

Attendees will receive a digital copy of the Perspective Data Book publication.

To RSVP, please contact Danielle Smith (danielles@lvgea.org) to receive your registration and individual sign-in link.

Those who have registered have the opportunity to submit questions for consideration.

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Las Vegas Local Breaking News, Headlines | fox5vegas.com

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Nevada ties daily record with 28 more reported COVID-19 deaths – Las Vegas Review-Journal

More than 1,100 cases of the coronavirus were reported in Nevada on Wednesday, as the number of deaths tied Tuesdays official state count the largest increase of daily reported deaths since the start of the pandemic.

According to data from the Department of Health and Human Services, 28 additional deaths again were reported as the official number across Nevada on Wednesday, bringing the total number of deaths in the state to 704.

However, due to differing reporting cycles between state and local health agencies, the daily recorded deaths were slightly different at 31 on Tuesday and 25 on Wednesday.

Of those 25 deaths reported by local agencies, 24 occurred in Clark County, according to data from the Southern Nevada Health District.

The discrepancy comes from three deaths reported by Washoe County on Tuesday afternoon but not recorded in Tuesdays total from the state health department.

The reporting delays by state and county health agencies make it unclear when the 25 new deaths recorded locally on Wednesday occurred.

Additionally, a count of the number of deaths from local and county agencies shows that 705 people have died across Nevada. The discrepancy comes from Nye County, which was reporting six deaths, while the state showed only five in the county.

The fifth and sixth deaths in Nye County were both reported on Monday, and county spokesman Arnold Knightly confirmed on Wednesday that the total was accurate.

According to the Department of Health and Human Services data, an additional 1,129 cases were reported across Nevada on Wednesday, raising the total cases in the state to 38,657. The totals from local agencies put the count a bit higher, at 38,661.

Tuesday saw the largest number of deaths reported in a single day across Nevada, with the official count from the Department of Health and Human Services at 28 additional deaths.

Wednesday also was the third day in a row that Nevada reported the highest number of combined suspected and confirmed COVID-19 patients hospitalized in the state since the state of the pandemic, with an additional seven hospitalizations since Tuesdays data. The number of combined and suspected hospitalizations on Wednesday stood at 1,102, according to state data.

Tuesday also was the second day in a row with the highest number of confirmed and suspected COVID-19 patients hospitalized in Nevada, according to the state data.

Both the state and Southern Nevada Health District also redistribute new cases and death data after daily announcements in an attempt to show when a patient started experiencing symptoms or when a death occurred.

The county data also comes with a disclaimer that daily totals may be skewed when a large number of laboratory tests are reported late.

In Clark County, an additional 1,032 cases were reported on Wednesday, bringing the county total to 33,057, according to data from the Southern Nevada Health District. The death total in the county was at 577 on Wednesday.

An estimated 23,401 people in Clark County have recovered from the virus, according to the health district.

The statewide infection rate on Wednesday continued to climb, reaching 9.63 percent, according to the state data. Experts consider the rate the number of cases divided by the number of people who have been tested a better indicator of the outbreak trends in Nevada than new cases.

The rate had been declining for more than two months before hitting a low of 5.20 percent on June 17. It has risen every day but one since then.

As of Wednesday, 401,440 people in Nevada have been tested for the virus, according to the state health department.

Nye County on Wednesday reported an additional 19 cases, bringing the county total to 270. All of the new cases were in Pahrump, the county said.

In other developments:

Updated numbers from the Clark County Detention Center show that as of Tuesday, 152 inmates have tested positive for the virus, 49 of whom remained in custody. On Wednesday, there were four more reported cases of Metropolitan Police Department employees who have tested positive for the virus, bringing the total to 132. There are 61 Metro employees waiting on test results, and a total of 662 employees have received a test.

At the Nye County Detention Center in Pahrump, at least 40 percent of the inmate population has tested positive for the virus, with 41 inmates testing positive as of Wednesday. Immigration and Customs Enforcement detainees account for at least 32 of the confirmed cases, according to the federal agency.

This is a developing story. Check back for updates.

Contact Katelyn Newberg at knewberg@reviewjournal.com or 702-383-0240. Follow @k_newberg on Twitter.

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Vegas broadcaster Bart Torres of Highway Vibe dies at 54 – Las Vegas Review-Journal

Even on the radio, you could feel Bart Torres smile over the airwaves.

I always remember that smile, and how much he loved Las Vegas, former Las Vegas Mayor Oscar Goodman said Monday of Torres, who died Sunday morning of a heart attack at his Las Vegas home. He was 54. I always enjoyed being with Bart, who was a really good guy in a tough, tough business.

Plans for a service for Torres are pending.

For 20 years ending in December 2018, Torres was host of the Highway Vibe radio show on The Highway Radio Network, KYYZ-FM, 99.7, in Las Vegas. He was inducted into the Nevada Broadcasters Hall of Fame in September 2018 and by then had become very well-known in Las Vegas entertainment circles.

Torres spent a few years as a videographer for Ronald Reagan, after Reagan left office, and some of his work is presented at the Reagan Presidential Library in Simi Valley, California.

Bart adored him. He was such a kind man, Torress wife, Ricki, says. He always asked about me and our new son. Bart had a lot of great memories working for Reagan. At events, he would most always get to meet the best of the best. So we have lots of video and pics with so many important people. And Nancy was very sweet to him as well, and always made sure he had eaten at the event since hed be working. They were such kind people.

In his youth, Torres also befriended Col. Tom Parker, Elvis Presleys legendary manager, an early radio guest. He insisted Bart call him Uncle Colonel, Ricki Torres said. Our middle son is actually named for him, Cole Parker Torres We always promised the colonel if we had another son, it would be his namesake.

For decades in Las Vegas, Torres voice, and zeal for the city, often accompanied tourists as they drove in from Southern California. Originally called Highway Radio, it was the only Vegas FM station motorists could tune in to on the drive from Barstow.

Goodman was a favored and frequent guest, and the two became close friends.

Whenever Carolyn and I would drive to Coronado, we would stop at Peggy Sues Diner on our way there, and on our way back, Goodman said, referring to the 50s-styled diner near Barstow on Interstate 15. Whenever wed stop there, the staff would tell us, We heard you on the radio with Bart!

Torres interviewed dozens of performers and newsmakers over the years, headliners ranging from Jerry Lewis, Don Rickles, Celine Dion and George Carlin. He sat with such Vegas resort icons as Sheldon Adelson and Steve Wynn. Torres show broadcast from several Las Vegas venues, and from Los Angeles.

Torres had a recent history of heart problems and had suffered a heart attack in July 2019. He had a pacemaker implanted in March. He and his wife, Ricki, visited Laughlin on Saturday, riding a wave runner along the Colorado River.

We had fantastic fun. He was doing great, he had been to the doctor on Tuesday and everything seemed perfect, Ricki Torres said. He was eating healthy, walking 8 miles a day.

But on Sunday, Torres awoke at 5 a.m. with chest pains and asked his wife to call an ambulance.

He passed before he ever left our driveway, Ricki Torres said. I didnt even get to say goodbye, or be with him at the end.

The couple celebrated their 30th wedding anniversary on June 9. It was a big deal for him, and for us, Ricki Torres said, adding that Torres was looking forward to turning 55 in August and had been cleared to vacation in Hawaii in November.

Torres is survived by three sons, Conner, 26; Cole, 22; and Cameron, 19.

Asked how her husband would want to be remembered, Ricki Torres said, I think he would want to be remembered as a good guy, a good person. He worked hard at being a good person.

John Katsilometes column runs daily in the A section. His PodKats! podcast can be found at reviewjournal.com/podcasts. Contact him at jkatsilometes@reviewjournal.com. Follow @johnnykats on Twitter, @JohnnyKats1 on Instagram.

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Las Vegas police searching for truck after shots fired on the Strip – KTNV Las Vegas

UPDATE JULY 20 4:30 P.M. Las Vegas police now say the only vehicle they are looking for is a white Dodge Ram. The other vehicle they were looking for has been eliminated as being involved.

13 Investigates searched online data and found that police have responded to 111 reports of crime since the shutdown and reopening of the Las Vegas Strip because of the coronavirus pandemic.

They have responded to calls about robberies, burglaries and assaults.

A month prior to the shutdown from mid-February to mid-March they investigated 183 reports for the same types of crimes in the same geographic area.

In the month since the Las Vegas Strip, there have been 167 reports.

ORIGINAL STORYLAS VEGAS (KTNV) -- Las Vegas Metropolitan Police Department has confirmed a shooting on Las Vegas Boulevard near Bellagio and Paris casino-resorts.

Upon arrival, police officers located shell casings in the area but no victims.

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Detectives are currently on scene investigating the matter.

Las Vegas Boulevard is currently open to traffic.

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Las Vegas police searching for truck after shots fired on the Strip - KTNV Las Vegas

Las Vegas blues and soul performer Bobby Jonz dies of Covid-19 at age 84 – KLAS – 8 News Now

LAS VEGAS (KLAS) A prominent Soul and Blues singer by the name of Bobby Jonz has died from COVID-19. Jonz, who was born Bobby Jones, lived and performed his legendary blues numbers in Las Vegas.

Jonzs record company released the following statements:

It is a sad day for Loveforce International Records, said Loveforce International CEO Mark Thomas. Covid-19 has claimed the life of one of our anchors, our beloved Bobby Jonz.

Bobby Jonz was like a brother to me, said recording artist Billy Ray Charles, who wrote In The Mood For Love. He will be missed by me and the entire blues community.

Jonz passed away Monday, July 21, at the Veterans Hospital in North Las Vegas. He was born Bob Willy Jones in Farmerville, Louisiana on January 2, 1936. He emigrated to Chicago in 1959 and, in a short time, replaced Blues Hall of Famer Junior Wells in the Blues Hall of Fame Blues band The Aces.

Jonz had a series of single recordings released by local Chicago labels throughout the 1960s and 1970s. He had several Southern Soul albums released during the 1980s and 1990s. He had hits with In The Mood For Love and Sneakin & Freakin.

Jonz recorded under both Bobby Jones and Bobby Jonz during his life. He was 84 years old.

Jones leaves behind an ex-wife, several children and grand children. He also leaves behind a wealth of music. Plans for a funeral and/or memorial service are pending due to the COVID-19 pandemic.

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Las Vegas blues and soul performer Bobby Jonz dies of Covid-19 at age 84 - KLAS - 8 News Now

Man accused of damaging RTC bus after being told to wear mask, police say – Las Vegas Review-Journal

A North Las Vegas man angry about having to wear a mask on a public bus is accused of smashing out the windshield of the bus in retaliation, police said.

Jason Easterbrook, 58, was arrested July 14 on suspicion of damaging transportation property, according to Clark County Detention Center records.

A Las Vegas police arrest report for Easterbrook states police were called to the area of Mojave Road and East Charleston Boulevard at 7:05 a.m. for a report of an RTC bus being damaged. A bus driver said a passenger, identified by police as Easterbrook, had attempted to board a bus without wearing a mask.

Easterbrook was told to put on a mask by the bus driver before boarding on the bus, an officer wrote. Easterbrook initially put it on but took it off as soon as he was seated inside the bus.

The bus driver told Easterbrook to put the mask back on and Easterbrook got angry, police said.

Easterbrook kicked the doors of the bus at a stop, then got off, picked up a rock and threw it through the front windshield of the bus, damaging and shattering it, police said.

There were no injuries. Police said Easterbrook was arrested a short distance away and that he confessed to throwing the rock.

Easterbrook claimed that the bus was his property and he needed to make renovations to it, a report states.

A criminal complaint in the case has not been filed. A status check on the case is scheduled for Sept. 15.

Contact Glenn Puit by email at gpuit@reviewjournal.com. Follow @GlennatRJ on Twitter.

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