Ethereum 2.0 and Polkadot Offer Alternative Solutions to Scaling Issue – Cointelegraph

After Ethereum co-founder Gavin Wood left the Ethereum Foundation in 2016, he wrote a white paper for a new kind of blockchain one that would use an innovative form of sharding and cross-chain communication to achieve the kind of scalability and interoperability that Ethereum 1.0 would never be able to manage. Woods new blockchain, called Polkadot, launched its first iteration in May and has recently moved to the second stage of the mainnet.

In the time that Wood has been developing Polkadot, the Ethereum core development team has been working on the biggest upgrade to Ethereums infrastructure since it launched in 2015. Ethereum 2.0, also dubbed Serenity, is due to launch its own first iteration this year, with a phased rollout over the next two years. Ethereum 2.0 will also use a variant of sharding as a means of ending the scalability woes that have plagued it since the initial coin offering boom in 2017.

Bearing in mind the entwined history of these two platforms, are the two comparable? And if so, in what ways?

Both Ethereum 2.0 and Polkadot use sharding to achieve scalability. Sharding involves partitioning the blockchain network, or its data, to enable parallel processing and thus increase throughput. However, sharding is a broad term, and these two projects utilize different methods.

Currently, Ethereum 1.0 operates on a single-chain structure where every node must validate every transaction. In contrast, Ethereum 2.0 has a main chain called the Beacon Chain that facilitates communication between the shards, which connect to the Beacon Chain. Shards can process in parallel, allowing a higher throughput than the single-chain structure.

Ethereum 2.0 will impose a particular condition on shards connecting to the Beacon Chain, in that each shard must have a uniform method for changing state with each block added to the blockchain. Essentially, a Beacon Chain is a series of ports or sockets like a USB connector where only those shards with the right shape of USB plug can connect to it.

Polkadot uses a different variant of sharding. The network also has a main chain called the Relay Chain. Shards on Polkadot are known as parachains and can also execute transactions in parallel. However, Polkadot uses a far more flexible meta-protocol to allow parachains to connect to the main chain, meaning that any parachain can determine its own rules regarding how it changes state. The only condition is that the Relay Chain validators can execute it using the meta-protocol, which uses standard WebAssembly. Coming back to the USB connector analogy, the Relay Chain serves as a kind of universal socket. Now anyone with any kind of plug can connect to Polkadot.

The flexibility described above means that Polkadot offers a high level of interoperability that wont be possible with Ethereum 2.0, as only Ethereum-specific shards can be part of the Ethereum ecosystem. Polkadot uses bridge parachains that can connect to external blockchains, offering two-way compatibility.

Effectively, Ethereum could connect to the Polkadot ecosystem via a bridge parachain so that DApp developers could interact with any other Polkadot parachain. However, the reverse isnt possible: Polkadot could not become a shard on Ethereums Beacon Chain. Moonbeam is one example of a bridge parachain that provides developers with an Ethereum-compatible smart contract platform thats built on Polkadot.

So far in the evolution of blockchain, interoperability hasnt played a significant role. However, perhaps because so many blockchains have evolved to become walled gardens, interoperability is starting to take more of a starring role in 2020. At last years Blockstack Summit in San Francisco, blockchain entrepreneur Andreas Antonopoulos put forward a compelling case for interoperability, explaining that any single chain that attracts sufficient development will eventually eat itself, requiring an infrastructure upgrade.

Related: Interoperable Blockchains May Be the Future of Finance but Have a Ways Yet to Go

If Antonopoulos is right, then much of the current infrastructure such as blockchain bridges or interoperable platforms like Polkadot could be key enablers of Ethereums future development.

Its also worth pointing out that Wood recognizes the inherent symbiosis in this relationship between the two platforms, having stated in a blog post that, ever since the Polkadot white paper was issued: We knew that bridging with the Ethereum ecosystem to help extend capabilities on either side would be one of the key points of the network.

Polkadot launched on mainnet in May, with the projects roadmap involving phased upgrades to a fully decentralized infrastructure with all planned governance in place. The first phase is proof-of-authority, which involves assembling validators for the network. The project recently launched its second phase, which is known as nominated proof-of-stake. This refers to an initial go-live of the networks consensus model. Assuming all goes well, the next step will involve implementation of the networks governance model.

Ethereum 2.0 is taking a somewhat different approach to the phased implementation whereby the full launch will come after phased updates. The Beacon Chain is expected to launch this summer, along with staking under the new proof-of-stake consensus. The move to full sharding is slated to come in the next phases.

While the Ethereum 2.0 project boasts some leading names within the blockchain developer space, including Ethereum co-founder Vitalik Buterin himself, there is no single team responsible for Ethereum 2.0 development and implementation. Several teams, or clients, are working on various iterations of Ethereum 2.0 as a means of maintaining network security.

Polkadot has been developed by a single firm called Parity Technologies a global team of engineers, cryptographers, solutions architects and researchers. Along with Polkadot, Parity has developed its Parity Ethereum client and Parity Zcash client.

Parity Technologies was founded by Wood and Jutta Steiner. Woods credentials are well established through his history with Ethereum and as the creator of the Solidity programming language, with Steiner also being one of the original Ethereum team members, having served as its first security chief. She is an applied mathematician and now the CEO of Parity.

One of the most significant challenges facing Ethereum 2.0 is the time its taking to bring the project to fruition. Theres been talk of a scalability upgrade since around 2017, and its likely to be 2022 by the time the full implementation is completed and thats assuming there are no further delays. However, Ethereum holds a critical advantage over Polkadot and all other blockchain platforms: It has a long-established developer base and community, and the most developer activity when compared to its competitors.

However, Ethereum 2.0 implementation delays have allowed other projects, of which Polkadot is obviously a top competitor, to develop their own platforms that offer additional attributes, such as interoperability. Polkadot does offer compatibility with Ethereum, meaning that developers could adopt the platform without necessarily moving away from their original base.

It will be intriguing to see how the two platforms play together once the full Ethereum 2.0 implementation is completed. If all goes well, each platform can complement the strengths of the other to create a connected blockchain network greater than the sum of its parts.

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Ethereum 2.0 and Polkadot Offer Alternative Solutions to Scaling Issue - Cointelegraph

Ripple CEO: Fiat and Crypto Should Coexist in Harmony – Ethereum World News

In summary:

The CEO of Ripple, Brad Garlinghouse, has expressed optimism in the move by the OCC declaring that US banks can now offer crypto custody solutions to their customers. The Office of the Comptroller of the Currency (OCC) explained the time was nigh for US banks to keep up with technology advancements as well as the growing needs of their customers to safely store digital assets.

It is with this background that Mr. Garlinghouse enthusiastically commented via Twitter that the move would foster innovation and provide a level playing field for all. Additionally, he expla ined that it was high time fiat and crypto coexisted in harmony. His exact comments were as follows

BOOM! Todays ruling is a huge step forward. The @USOCC is absolutely leading the way to foster innovation, protect consumers and provide a level playing field for all. The future has never been fiat versus crypto these can and should coexist in harmony!

His comments were echoed by Ripples general counsel, Stuart Alderoty, via the following Tweet.

To note is that Brad Garlinghouse has been calling for regulatory clarity in the US with regards to the crypto and blockchain industries. This move by the OCC provides an avenue for Ripple to offer its various payment settlement solutions to the various US banks by possibly highlighting the speed, efficiency and interoperability of the XRP ledger.

Disclaimer:This article is not meant to give financial advice. Any additional opinion herein is purely the authors and does not represent the opinion of EWN or any of its other writers. Please carry out your own research before investing in any of the numerous cryptocurrencies available. Thank you.

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Ripple CEO: Fiat and Crypto Should Coexist in Harmony - Ethereum World News

Ethereum (ETH) Down $2.79 Over Past 4 Hours, Outperforms All Top Cryptos to Start the Day; Entered Today Up For the 3rd Day In A Row – CFDTrading

Ethereum 4 Hour Price Update

Updated July 24, 2020 11:19 AM GMT (07:19 AM EST)

275.23 (USD) was the opening price of the four-hour candle for Ethereum, resulting in the previous 4 hours being one in which price moved up 1.52% ($4.13) from the previous 4 hours. Ethereum outperformed all 5 assets in the Top Cryptos asset class since the previous 4 hours. Congrats to its holders!

Ethereum came into today up 4.29% ($11.33) from the open of the day prior, marking the 3rd day in a row an increase has occurred. The price move occurred on stronger volume; specifically, yesterdays volume was up 111.68% from the day prior, and up 174.82% from the same day the week before. On a relative basis, the day prior was pretty good: Ethereum bested all 5 of the assets in the Top Cryptos class Below is a daily price chart of Ethereum.

The clearest trend exists on the 90 day timeframe, which shows price moving up over that time. For another vantage point, consider that Ethereums price has gone up 6 of the previous 10 trading days.

Behold! Here are the top tweets related to Ethereum:

Some BTC maximalists are making fun of ETH gas prices, but when you say the same thing about BTC blocks being full and fees going up, then they say thats Satoshis vision to have full blocks.Is Ethereum fulfilling Satoshis vision better than bitcoin?

@JaEsf @AFDudley0 @austingriffith @badcryptobitch @dannyryan @DZack23 @ercwl @gakonst @gluk64 @hasufl @haydenzadams @hudsonjameson @jadler0 @mhswende @musalbas @peter_szilagyi @_prestwich @samczsun @tayvano_ @VitalikButerin @wekabot tbh I mostly work on Ethereum now because it does everything I want. The eureka when I was designing an atomic swap protocol for gambling on a hard fork. It took me 3 months in Bitcoin to design (no impl) vs 1 day in Ethereum (with a working solidity contract).

its somewhat crazy to call the beacon chain eth2.0, considering how it does 0 Ethereum things hello, i have invented car2.0. it has no wheels, and does not go. you cannot sit in it. someday i will replace engine with hover, probably. car2.0, yo

In terms of news links for Ethereum heres one to try:

eth2 quick update no. 13 | Ethereum Foundation Blog

I want to give a quick update on the eth1+eth2 merger progress and to give a huge shout-out to Mikhail (TXRX) and Guillaume (geth) for their excellent work.The high level on the client relationship can be found here; a more detailed scope of the merger discussed by Mikhail is here; and a discussion of the architecture of a geth based eth1-engine (called Catalyst) by Guillaume is here.Guillaumes Catalyst a version of geth which defers its consensus to RPC calls (i.e. an eth2 client) is built and ready to go; and Mikhails Phase 1 implementation is running fully sharded eth2 simulations with select shards deferring block production and validity calls to a local, stubbed eth1-engine.

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Ethereum (ETH) Down $2.79 Over Past 4 Hours, Outperforms All Top Cryptos to Start the Day; Entered Today Up For the 3rd Day In A Row - CFDTrading

EOS, Ethereum and Ripple’s XRP Daily Tech Analysis July 19th, 2020 – FX Empire

For the day ahead

Ethereum would need to avoid a fall through the $235 pivot to support a run at the first major resistance level at $237.76.

Support from the broader market would be needed, however, for Ethereum to break out from Saturdays high $236.97.

Barring an extended crypto rally, the first major resistance level should cap any upside.

Failure to avoid a fall through the $235 pivot would bring the first major support level at $233.03 into play.

Barring another extended sell-off, Ethereum should continue to steer clear of sub-$230 levels. The second major support level at $230.27 should limit any downside.

First Major Support Level: $233.03

Pivot Level: $235.00

First Major Resistance Level: $237.76

23.6% FIB Retracement Level: $257

38.2% FIB Retracement Level: $367

62% FIB Retracement Level: $543

Ripples XRP rallied by 2.94% on Saturday. Following a 0.03% loss on Friday, Ripples XRP ended the day at $0.20019.

It was a relatively bearish start to the day. Ripples XRP fell to an early morning intraday low $0.19413 before making a move.

Steering clear of the first major support level at $0.1913, Ripples XRP struck a late afternoon intraday high $0.20232.

Ripples XRP broke through the first major resistance level at $0.1982 and the second major resistance level at $0.2018.

A late pullback saw Ripples XRP fall back to $0.19960 levels before wrapping up the day at $0.20 levels.

At the time of writing, Ripples XRP was up by 0.63% to $0.20145. A mixed start to the day saw Ripples XRP fall to an early morning low $0.19988 before striking a high $0.20150.

Ripples XRP left the major support and resistance levels untested early on.

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EOS, Ethereum and Ripple's XRP Daily Tech Analysis July 19th, 2020 - FX Empire

Ethereum (ETH) Down $0.45 in Last 4 Hours, Tops All Top Cryptos to Start the Day; Moves Up For the 3rd Day In A Row – CFDTrading

Ethereum 4 Hour Price Update

Updated July 24, 2020 03:20 PM GMT (11:20 AM EST)

274.74 (USD) was the opening price of the four-hour candle for Ethereum, resulting in the last 4 hour candle being one in which price moved down 0.23% ($0.62) from the last 4 hour candle. Out of the 5 instruments in the Top Cryptos asset class, Ethereum ended up ranking 4th for the four-hour candle in terms of price change relative to the last 4 hour candle.

Ethereum closed yesterday up 4.29% ($11.33); this denotes the 3rd day in a row an increase has occurred. The price move occurred on stronger volume; specifically, yesterdays volume was up 111.68% from the day prior, and up 174.82% from the same day the week before. Ethereum outperformed all 5 assets in the Top Cryptos asset class since yesterday. Congrats to its holders! Lets take a look at the daily price chart of Ethereum.

Trend traders will want to observe that the strongest trend appears on the 90 day horizon; over that time period, price has been moving up. For another vantage point, consider that Ethereums price has gone up 6 of the previous 10 trading days.

Behold! Here are the top tweets related to Ethereum:

At the end of the day my name is Ethereum Jack because I have been buying its cyclic bottom to make myself more Bitcoin and so far it has been exactly doing thatIf youre a true #Bitcoin maximalist you dont pass up on such opportunities

Some BTC maximalists are making fun of ETH gas prices, but when you say the same thing about BTC blocks being full and fees going up, then they say thats Satoshis vision to have full blocks.Is Ethereum fulfilling Satoshis vision better than bitcoin?

@JaEsf @AFDudley0 @austingriffith @badcryptobitch @dannyryan @DZack23 @ercwl @gakonst @gluk64 @hasufl @haydenzadams @hudsonjameson @jadler0 @mhswende @musalbas @peter_szilagyi @_prestwich @samczsun @tayvano_ @VitalikButerin @wekabot tbh I mostly work on Ethereum now because it does everything I want. The eureka when I was designing an atomic swap protocol for gambling on a hard fork. It took me 3 months in Bitcoin to design (no impl) vs 1 day in Ethereum (with a working solidity contract).

As for a news story related to Ethereum getting some buzz:

eth2 quick update no. 13 | Ethereum Foundation Blog

I want to give a quick update on the eth1+eth2 merger progress and to give a huge shout-out to Mikhail (TXRX) and Guillaume (geth) for their excellent work.The high level on the client relationship can be found here; a more detailed scope of the merger discussed by Mikhail is here; and a discussion of the architecture of a geth based eth1-engine (called Catalyst) by Guillaume is here.Guillaumes Catalyst a version of geth which defers its consensus to RPC calls (i.e. an eth2 client) is built and ready to go; and Mikhails Phase 1 implementation is running fully sharded eth2 simulations with select shards deferring block production and validity calls to a local, stubbed eth1-engine.

Originally posted here:

Ethereum (ETH) Down $0.45 in Last 4 Hours, Tops All Top Cryptos to Start the Day; Moves Up For the 3rd Day In A Row - CFDTrading

Whales Are Buying Three Altcoins As Bitcoin and Ethereum Tread Water, According to Crypto Research Report – The Daily Hodl

New analysis from the Liechtenstein-based Crypto Research Report shows crypto whales are actively accumulating three altcoins as Bitcoin and Ethereum continue to consolidate.

Demelza Hays, a former cryptocurrency fund manager and Forbes 30 under 30 member, says the decentralized finance (DeFi) tokens Aave (LEND), Ren (REN), and Kyber Network (KNC) continue to see strong interest from crypto whales after posting significant gains over the past few months.

In the past 30 days, the balance of top 100 KNC whales has grown by a total of 30.6 million KNC (~$48.1 million at the time of writing). In the same time frame, the top 100 LEND whales accumulated an additional 39.6 million LEND (~$10.1 million at the time of writing) to their collective bags, while the top 100 REN whales added 5.3 million REN (~$850,000 at the time of writing) more to their holdings.

Hays says the increase in the balance of top 100 LEND, REN, and KNC whales points to accumulation while indicating high investor optimism.

Its not just whales who are driving the value of these three DeFi assets. Hays explains that LEND, REN, and KNC have also caught the attention of retail investors.

Since the start of the month, the number of addresses holding more than 1000 REN (~$150 at the time of writing) has increased by 550, the number of addresses holding more than 1000 LEND (~$250 at the time of writing) has increased by 817, while the number of addresses holding more than 100 KNC (~$157 at the time of writing) has grown by an additional 150.

Hays says whales and retail traders will likely alleviate sell pressure by holding onto their assets, pointing to the continuation of the uptrend of LEND, REN, and KNC.

Featured Image: Shutterstock/camilkuo

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Whales Are Buying Three Altcoins As Bitcoin and Ethereum Tread Water, According to Crypto Research Report - The Daily Hodl

COVID-19 affects HIV and tuberculosis care – Science Magazine

The GeneXpert cartridge-based platform is used routinely at the CAPRISA clinic in Durban, South Africa, to rapidly test for tuberculosis and HIV viral load, but it is now also being used to test for COVID-19.

Shortly after instituting coronavirus disease 2019 (COVID-19) mitigation measures, such as banning air travel and closing schools, the South African government implemented a national lockdown on 27 March 2020 when there were 402 cases and the number of cases was doubling every 2 days (1). This drastic step, which set out to curb viral transmission by restricting the movement of people and their interactions, has had several unintended consequences for the provision of health care services for other prevalent conditions, in particular the prevention and treatment of tuberculosis (TB) and HIV. Key resources that had been extensively built up over decades for the control of HIV and TB are now being redirected to control COVID-19 in various countries in Africa, particularly South Africa. These include diagnostic platforms, community outreach programs, medical care access, and research infrastructure. However, the COVID-19 response also provides potential opportunities to enhance HIV and TB control.

In Africa, the COVID-19 epidemic is unfolding against a backdrop of the longstanding TB and HIV epidemics. South Africa ranks among the worst-affected countries in the world for both diseases. Despite having just 0.7% of the world's population, South Africa is home to 20% (7.7 to 7.9 million people) of the global burden of HIV infection (2) and ranks among the worst affected countries in the world for TB, with the fourth highest rate of HIV-TB co-infection (59%) (3). South Africa has made steady progress since 2010 in controlling both diseases. Increased access to antiretroviral drugs for treatment and for prevention of mother-to-child transmission of HIV has resulted in a 33% reduction in AIDS-related deaths between 2010 and 2018 (2). Similarly, the death rate among TB cases has declined from 224 per 100,000 population in 2010 to 110 per 100,000 population in 2018 (3). Have the strategies implemented for COVID-19 mitigation, particularly the lockdown, inadvertently threatened these gains in HIV and TB?

HIV and TB polymerase chain reaction (PCR) tests are key to treatment initiation and monitoring to achieve the United Nations goals for the control of HIV and TB. Disturbingly, these diagnostic tests declined during the lockdown. The 59% drop in the median number of daily GeneXpert TB testsa cartridge-based PCR test capable of diagnosing TB within 2 hours while simultaneously testing for drug resistancewas accompanied by a 33% reduction in new TB diagnoses (4). The restriction of people's movement and curtailment of public transport has led to substantial declines in patient attendance at health care facilities. A survey of 339 individuals in South Africa revealed that 57% were apprehensive about visiting a clinic or hospital during the lockdown, in part because of concerns that they may be exposed to infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from COVID-19 patients attending these facilities (5). Delayed HIV and TB testing impedes initiation of appropriate treatment, which increases the risk of new infections and drug resistance (6).

Both TB and HIV diagnostic platforms are important contributors to COVID-19 testing. The GeneXpert point-of-care testing platform, which is widely used in South Africa to diagnose TB, with more than 2 million individuals tested annually (7), is also being used to diagnose COVID-19. Until now, the limited availability of the GeneXpert COVID-19 cartridges has meant that spare capacity is mostly being used with little, if any, displacement of TB testing. Because there was also a decline in CD4+ assays (to test for immune status in HIV patients), it indicates decreased demand rather than displacement because this assay is not used for COVID-19. This may change as the demand for COVID-19 point-of-care testing rises and GeneXpert cartridges for COVID-19 become more readily available.

South African clinical laboratories have substantial capacity to perform high-throughput PCR assays for HIV viral load (more than 50,000 tests per day). However, the lack of COVID-19 test kits in South Africa, stemming from the global shortage, has meant that the available spare capacity on these platforms has sufficed for COVID-19 testing. The full potential of this PCR capacity is likely to be called upon when the country needs to expand COVID-19 PCR testing for the expected surge in cases, estimated to exceed 1 million at peak (8). Laboratory capacity for PCR testing developed for HIV and TB is now an essential resource for COVID-19 testing. The use of this capacity for COVID-19 needs to be monitored to identify and address any potential displacement of HIV and TB testing.

South Africa's experience in dealing with substantial HIV and TB epidemics has laid the foundations for the country's rapid, early community-based response. Both TB and COVID-19 are respiratory infections and can present with similar symptoms. They therefore present substantial infection control challenges, requiring timely and rapid diagnosis. Both diseases can spread more easily in conditions associated with poverty where social distancing is difficult to implement. Well-established community outreach capabilities for contact tracing, established for TB, were deployed to undertake contact tracing and quarantine monitoring for COVID-19.

With the highest HIV burden in the world, South Africa has a highly developed network of health care providers that includes tens of thousands of community health care workers who are trained to interact safely with infectious individuals and have experience in undertaking door-to-door visits in South Africa's most socially vulnerable communities. About 28,000 HIV community health care workers were deployed for COVID-19 symptom screening and testing referral (HIV outreach was put on hold) in 993 vulnerable, high-density communities, many lacking running water, to identify cases and thus reduce time to diagnosis and hence limit transmission. As clinical cases increased, there were insufficient tests for community-based screening, creating testing backlogs that delayed hospital patient results and led to curtailment of the community program with proposed adjustment to screening and quarantine without testing.

The established community engagement and outreach for HIV, TB, and noncommunicable diseases (such as hypertension and diabetes) provide an opportunity for integrating screening and testing in the long-term COVID-19 response. This approach will play an important role in reaching at-risk populations who do not readily make use of health services to establish a broader program of health promotion, prevention, and early detection. Such integration can be facilitated by the expansion of mobile onsite rapid testing approaches, using newly developed COVID-19 tests (9) and existing tests for HIV and other conditions on readily accessible samples such as saliva and blood from finger pricks. Combining health promotion programs for these diseases will reduce duplication and provide synergistic messaging because social distancing affects not only COVID-19 transmission but also that of TB and other respiratory infections. After the COVID-19 surge, integrated services could potentially provide an important approach to balancing ongoing vigilance for COVID-19 with early community-based detection of individuals with HIV and/or TB.

Access to medical care for nonCOVID-19 conditions was limited during the lockdown, with health facilities experiencing declines in the number of TB and HIV patients collecting their medication on schedule. The World Health Organization estimates that a 6-month disruption of antiretroviral therapy could lead to more than 500,000 additional deaths from AIDS-related illness in 2021 and a reversal of gains made in the prevention of mother-to-child transmission (10). In South Africa, 1090 TB patients and 10,950 HIV patients in one province have not collected their medications on schedule since the start of the national lockdown (11). A national survey of 19,330 individuals in South Africa found that 13.2% indicated that their medication for chronic disease was inaccessible during the lockdown (12). Furthermore, hospital admissions for HIV and TB declined as a result of hospitals reducing nonurgent admissions in preparation for a surge of COVID-19 cases and owing to closures to reduce exposure to COVID-19 patients. The potential negative impact on the continuity of care for HIV and TB patients could have substantial repercussions for both treatment and control, including development of drug resistance (6).

The biological and epidemiological interaction of COVID-19, HIV, and TB is not well understood. Patients immunocompromised by HIV or with TB lung disease could be more susceptible to severe COVID-19. However, preliminary results from a study of 12,987 COVID-19 patients in South Africa indicate that HIV and TB have a modest effect on COVID-19 mortality, with 12% and 2% of COVID-19 deaths attributable to HIV and TB, respectively, compared to 52% of COVID-19 deaths attributable to diabetes (13). The small contribution of HIV and TB to COVID-19 mortality is mainly due to these deaths occurring in older people, in whom HIV and active TB are not common. Integrated medical care for these three conditions is important as COVID-19 patients coinfected with HIV or TB start attending health care services in larger numbers.

South Africa's COVID-19 response, especially the lockdown, has led to substantial economic hardship, particularly among the poor and vulnerable. This has had a disproportionate impact on women, many of whom are self-employed or day laborers without a safety net (14). This may have a longer-term effect on increasing diseases associated with poverty (such as TB) and with gender, such as HIV, for which young women bear a disproportionate burden (15). The social determinants of HIV and TB will need to be carefully monitored to assess the impact of COVID-19. The effect of the lockdown on the economy, including declining taxes, is also likely to negatively affect funding for HIV and TB programs, among many others.

New and ongoing research on HIV and TB prevention and treatment have been severely affected by the COVID-19 epidemic. At the initiation of the lockdown in South Africa, the National Health Research Ethics Committee suspended all medical research, including clinical trials. Research progress on these two conditions has also slowed because several of the country's AIDS and TB researchers are redirecting their efforts to COVID-19. However, COVID-19 research efforts have increased collaboration and created new approaches to speed up therapeutic and vaccine development and testing, which will likely have long-term benefits for medical research beyond COVID-19. Several countries in Africa have well-developed HIV and TB clinical trial infrastructure that could contribute to COVID-19 vaccine trials. Past investments in infectious disease training and research have generated handsome returns to the COVID-19 response, highlighting the importance of maintaining these investments in the future.

Acknowledgments: We thank C. Baxter, W. Stevens, and A. Rademeyer for their assistance as well as the South African Department of Science and Innovation and Medical Research Council. Both authors are members of the South African Ministerial Advisory Committee for COVID-19.

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COVID-19 affects HIV and tuberculosis care - Science Magazine

‘The challenges that labs are facing are complex’: Why COVID-19 test results are so delayed – NBC News

The enormous number of Americans getting swabbed for the coronavirus has overwhelmed every step of the COVID-19 testing process, creating shortages of critical supplies in laboratories and inundating them with more specimens than they can process.

The testing spike, which experts say has been particularly dramatic over the past month as more coronavirus hot spots have popped up, has meant waits of up to two weeks or more for test results in some cases a far from ideal turnaround time.

Laboratories say they are working as fast as they can.

Full coverage of the coronavirus outbreak

"The challenges that labs are facing are complex," said Louise Serio, a spokesperson for the American Clinical Laboratory Association, a trade group that represents companies such as Quest Diagnostics and LabCorp. "There is a significant strain on the global supply chain."

Since the beginning of the pandemic, the American Clinical Laboratory Association's members have performed more than 23 million COVID-19 tests, Serio said. Testing capacity is increasing every week, she said, and employees are working round-the-clock to run as many tests as possible, but they are running out of necessary chemicals and other products faster than their manufacturers can replenish them.

"What we have consistently heard from members is that reagents, test kits, pipettes and platforms are all in great demand right now," she said.

The backlog could get worse if the outbreak continues on its current trajectory. On Thursday, the United States reached a somber milestone, surpassing 4 million confirmed coronavirus cases nationwide, according to data compiled by NBC News, just 15 days after hitting the 3 million mark.

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Dr. Scott Gottlieb, the former commissioner of the Food and Drug Administration, said on MSNBC's "Morning Joe" that access to testing and quick results is "likely to continue to be a challenging issue heading into the fall."

Testing lags will make it significantly harder to stop transmission of the virus, he said.

"After about 48 hours, the test really isn't that useful for the clinical management of the patient," Gottlieb said. "At that point, you're not going to be able to use the result to do effective contact tracing. Too much time has passed, and you're not giving information back to the provider and the patient that they could use."

His comments echoed those of Dr. Brett Giroir, the assistant secretary of health and human services for health, who is overseeing U.S. coronavirus testing and who has said three days is a "reasonable turnaround time" for results.

But given the surge in demand, that has been difficult to attain.

While some COVID-19 tests are done by a more rapid, cartridge-based method in hospitals for patients who are admitted, a much larger percentage in the U.S. are done by commercial labs.

Mike Geller, a spokesman for LabCorp, said LabCorp has so far performed 7.5 million molecular tests for COVID-19 and is processing 165,000 tests a day, with plans to increase capacity further. The average time to deliver results is three to five days from when a specimen was picked up; before the surge, the turnaround time was one to two days, he said.

Jim Davis, executive vice president of general diagnostics at Quest Diagnostics, said Quest has performed more than 8.5 million tests and is processing 130,000 tests a day. Quest anticipates that by the end of the month, it will have a daily capacity of 150,000 tests, which should help with the delays: Average turnaround time for test results right now is at least seven days, up from two to three days until several weeks ago, Davis said.

While Quest's test capacity has doubled over the last two months, demand has tripled, Davis said, with the last three to four weeks representing a steep increase. Labs are staffed 24/7, which they were not before the pandemic.

"We're asking everyone right now to work overtime," Davis said.

Federal funding and clearer guidance on testing from the federal government could help get turnaround times down. This week, the American Clinical Laboratory Association was among 50 health care organizations to call on Congress to dedicate more funding for testing.

"If the demand keeps increasing like it's been increasing over the last couple of weeks, the lab industry will never be able to keep up with it."

In the meantime, to best accommodate the backlogs, many testing sites are prioritizing certain patients.

At Northwell Health, New York's largest health care provider, screening tests for employment, travel or summer camp are considered lowest priority; those tests are typically sent out to the national commercial laboratories, while symptomatic patients awaiting clinical treatments are put at the top of the list, with their tests performed at Northwell's regional laboratories, said Dr. Dwayne Breining, executive director of Northwell Health Laboratories.

The turnaround time at the regional laboratories is one to two days, he said. (Northwell's hospitals, meanwhile, get results within thee hours using their cartridge tests.)

Breining said the U.S.'s maxed-out testing capacity reflects the country's struggle to contain the spread of the virus, and he urged Americans to take precautions.

"If the demand keeps increasing like it's been increasing over the last couple of weeks, the lab industry will never be able to keep up with it," he said. "I think the top priority is going to be mitigating the clinical spread of this virus by doing things we know work: things like social distancing, masking and monitoring.

"All those things make a huge difference," he added. "That would allow you to slow it down enough so that not only the lab testing industry, but the entire medical system, can catch up."

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'The challenges that labs are facing are complex': Why COVID-19 test results are so delayed - NBC News

More Floridians Are Unemployed Because Of COVID-19, Scammers Are Trying To Take Advantage – WUFT

As if the economic impacts of the COVID-19 pandemic and subsequent job losses werent bad enough, those who are now looking for new jobs have an additional worry.

For the thousands who lost jobs due to mandatory shutdowns across Florida and the nation, navigating job listing websites like Indeed or LinkedIn also means watching out for new scams.

Using information from online resumes, scammers sometimes contact their targets and offer fake jobs using the names of real companies. Many who are desperate for work fall victim to these scams in hopes of finding employment.

Victoria Echagaray, 17, of Miami, is one. She posted her resume to CareerBuilder and was subsequently contacted by what later turned out to be a scammer.

It felt kind of invasive, because they were able to find my information so easily, Echagaray said.

It began when she received a call about a job and then corresponded with the company through email. The job was a remote position as a system administrative customer service representative.

The position purported to offer $35 an hour often double what such a job would pay in most parts of the United States.

It didnt add up to me, so I was very hesitant but they made it seem super convincing, Echagaray said.

After back-and-forth communication with the company, an interview was set up through a messaging app called Telegram, though due to concern about suspicious content in the emails, she decided to not go through with it.

I figured out that this is 100% a scam, Echagaray said. She then reported the incident to CareerBuilder and tried to file a police report but was told nothing could be done. Echagaray said she has since received more scam emails that used information from her online resume.

The outcome was even worse for another Miami resident, 22-year-old Elizabeth Biswell, who lost her job at a small greeting card company where shed worked for five years.

She turned to LinkedIn and Indeed to search for work, posting her resume to both sites, and soon heard from a recruiter claiming to be from a multinational company, Altair Engineering.

She said I was qualified based off of my resume and quoted certain skills from my resume, Biswell said.

After a two-hour interview through the app Telegram, Biswell was offered a position of office manager and she accepted.

I gave them a copy of my drivers license, the W-4 form, which has your Social Security (Number) on it, and direct deposit information, she said. Afterwards, she began working for the company from home, saying, I was to wake up at eight in the morning every morning to train virtually.

The company then sent her a check for $2,500 to deposit and use to buy equipment in order to work remotely. They asked her to buy the required equipment through their verified seller and pay via PayPal.

It wasnt that odd because at my last job I had equipment for my home that I bought myself with my company card, Biswell said.

Three days later, her bank notified her that the check was fraudulent. After speaking to the companys supposed HR representative about the issue, Biswell realized the job was a scam.

I was left without a job, my identity was stolen, I was out $2,500, she said.

The scammers were using an Altair domain name to send all emails, impersonating employees of Altair, and using actual videos made by Altair to train employees. The real Altair is aware of the issue and added a disclaimer on its website stating, We are taking this matter seriously and are working with authorities to attempt to terminate these activities.

The scammers reached Biswell through Indeed.com, which according to the Better Business Bureau is the most reported online platform for employment scams. A statement from Indeed about the problem reads, in part, we encourage job seekers to report any suspect job advertisements to us, or if they feel it necessary, to make a report to the police.

Since the beginning of March, more than 16,000 scams throughout the United States have been reported to the Better Business Bureau Scam Tracker. Of those, 1,184 have been employment-related scams and 1,257 have been COVID-19 related scams.

Within Florida, the state Attorney Generals Office has, since March, issued more than a dozen alerts to help Floridians avoid COVID-19-related scams. The office recommends tips to avoid employment scams, including researching the company before accepting a job offer, looking for red flags in emails such as spelling and grammatical errors and never sending money in the form of checks, gift cards, or wire transfer to secure a job.

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More Floridians Are Unemployed Because Of COVID-19, Scammers Are Trying To Take Advantage - WUFT

Health service says there is solution for COVID-19 test backlogs ahead of flu season – Wink News

WINK NEWS

Many of you have spent days full of anxiousness and worry wondering if you have the coronavirus. Youve waited weeks to get your COVID-19 test result back.

Lee Health mentioned Thursday the increased demand is causing a longer wait for results.

Wednesday, Quest Diagnostics warned this flu season, the wait time could get even worse because the demand would be higher.

Some of the people reaching out to WINK News, whove had long waits to get their test results, are worried about getting loved ones sick. Others mentioned they couldnt go back to work without a negative test result. In some cases, thats taking weeks.

Thursday were heard solutions from one testing company about how to get faster results and why its important to prepare now for the upcoming flu season.

Its your classic bottleneck, said Justin Bellante, the co-founder and CEO of BioIQ. And its obviously a losing strategy.

Testing is becoming harder to keep up with.

I did not see why this should take so long, said Pauline Murphy, who waited two weeks for results.

More than 3 million Floridians have been tested for COVID-19 since March.

The thing that I kept saying was, If I was positive, how many people have I been in contact with that now I have to go back two weeks and think about that? Murphy explained.

But getting results quickly is even a challenge for health care providers like lee health.

These longer wait times naturally lead to frustration and anxiety, said Dr. Larry Antonucci, the president and CEO of Lee Health. Frankly, were frustrated too.

Collection sites and hospitals are sending samples to labs across the state.

We have a standard clinical lab infrastructure in this country, and its very good at one type of function, Bellante said. Thats routine testing for heart disease, diabetes and things like this. Its not made for a pandemic.

Bellante says Florida Department of Health needs to start working with other states where cases are not surging.

We should be leveraging labs in the middle of the country that probably have a lot of spare capacity right now because theyre not in a hot spot, Bellante said.

Bellante says that would get results back much faster. His company was also just approved for a new test that can also tell you if you have the flu, including which strain.

Bellante told us its critical to start preparing for flu season now so lab results dont get even more delayed. He says the faster someone knows what they are sick with, the faster they can get the appropriate treatment.

Imagine now going into the flu season here, Bellante said. You have, you know, three, four, five times the number of people that are symptomatic, and theyre trying to figure out if they have COVID or the flu. So, if you have five times more people that are symptomatic, you may need five times more testing that we have today.

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Health service says there is solution for COVID-19 test backlogs ahead of flu season - Wink News

More than 90 babies have tested positive for COVID-19 in Travis County, Austin Public Health reports – KXAN.com

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More than 90 babies have tested positive for COVID-19 in Travis County, Austin Public Health reports - KXAN.com

CLR 131 Leads a New Generation of Lipid-Based Cancer Drug Delivery Systems – OncLive

A novel compound that uses abundant lipids in cancer cell membranes to deliver a radioisotope to the tumor environment shows early signs of efficacy in a range of B-cell malignancies, including multiple myeloma.1,2

CLR 131 is a phospholipid-drug conjugate (PDC) designed to provide a payload of iodine-131 directly to the cytosol and cytoplasm of tumor cells.3 Cellectar Biosciences, a biopharmaceutical company based in Florham Park, New Jersey, is investigating the potential of CLR 131 in hematologic and solid tumors. The company also is exploring its PDC approach as a platform technology for other oncologic conjugates.4

Positive clinical trial data have been announced for patients with B-cell malignancies, 2 including multiple myeloma, and CLR 131 has secured fast track designation from the FDA for 3 separate indications.5-7 If it lives up to its potential, CLR 131 could be the first of many such drugs from Cellectar, with other payloads being explored.1

Meanwhile, the underlying technology shines a light on the broader use of lipids as vehicles for cancer therapies. With the advent of nanotechnology in medicine, lipid-based carriers have been designed to encapsulate drugs to improve delivery to the tumor site, in the hopes of reducing generalized toxicity and improving therapeutic effect.8-10

Several FDA-approved liposomal formulations of common chemotherapy drugs are on the market.11 Ongoing clinical efforts aim to improve the efficacy of some of these drugs; notably, daunorubicin plus cytarabine (CPX-351; Vyxeos)12 and liposomal irinotecan (Onivyde).13 CPX-351 was initially approved in 2017 in acute myeloid leukemia settings and Onivyde was cleared in 2015 for progressive metastatic pancreatic adenocarcinoma.

Additionally, newer lipid-based strategies aimed at overcoming the challenges of liposomal formulations are in development. These include SB05-EndoTAG-1 (SynCore Biotechnology), which combines paclitaxel with lipids14; mRNA-2416 (Moderna), which encodes OX40L in a lipid nanoparticle15; and Promitil (LipoMedix), a lipid-based form of mitomycin-C.16

Investigators have long sought more specific cancer drugs with reduced off-target toxicity and enhanced therapeutic efficacy. The development of molecularly targeted therapies has been one result, but new drug delivery systems may achieve similar goals. Thanks to the advent of nanotechnology, significant advances in the development of drug carrier technologies for cancer therapy have occurred in the past several decades.8-10

Broadly speaking, drug carriers are designed to shield drugs from interaction with healthy cells and facilitate accumulation at the tumor site. The latter is believed to occur as a result of the enhanced permeability and retention effect. Nanoparticles are too big to readily pass through the normal vasculature into healthy tissues but not the abnormal, leaky blood vessels characteristic of the tumor microenvironment. The lack of lymphatic drainage from tumor vessels adds to this effect.17

Nanoparticles prepared from natural polymers, such as lipids, proteins, and peptides, represent the most promising approach. In particular, liposomes are the most extensively studied type of nanoparticle drug carrier and account for first generation of FDA-approved lipidbased drug delivery systems.18

Liposomes are spherical vesicles composed of 1 or more phospholipid bilayers surrounding an aqueous core. Depending on its properties, a drug can be encapsulated within the core (a hydrophilic drug) or held in the bilayer (a hydrophobic drug) (Figure 1).8,11

Among their advantages over naked drugs, liposomes and other lipid-based delivery systems can reduce toxicity, prolong half-life in the circulation, and improve pharmacokinetics. Additionally, because of their biocompatibility with cell membranes, they are more readily taken up into cells via endocytosis. Because the drug remains behind a lipid barrier once inside the cell, being released only upon lysosomal degradation, it may avoid eviction from the cell by transporter pumps that play a large role in drug resistance.9,11,19

Chemotherapy Delivery

Beginning with the 1995 approval of doxorubicin hydrochloride liposome injection (Doxil) for the treatment of AIDS-related Kaposi sarcoma and, subsequently, multiple myeloma and ovarian cancer, severalliposomal formulations of conventional chemotherapies have become available.9,11

Despite better developed drug properties, some approved liposomal formulations only moderately improved patient survival compared with conventional chemotherapy.11 Their development revealed a number of inherent challenges. Early on, investigators discovered that liposomes were rapidly recognized and engulfed by macrophages, which led to their destruction by the mononuclear phagocyte system.10,20

Nevertheless, ongoing clinical development has demonstrated greater efficacy for several of these compounds. CPX-351 continued to show an overall survival (OS) benefit versus conventional 7 + 3 chemotherapy for patients with newly diagnosed high-risk/secondary acute myeloid leukemia in findings from a phase 3 trial (NCT01696084) presented at the 2020 European Hematology Association Virtual Congress.12

After a median follow-up of 60.65 months, the median OS was 9.33 months (95% CI, 6.37-11.86) and 5.95 months with CPX-351 and 7 + 3, respectively (HR, 0.70; 95% CI, 0.55-0.91). The estimated 3- and 5-year OS rates were also higher with CPX-351 versus 7 + 3, at 21% versus 9% and 18% versus 8%, respectively.12

The combination of Onivyde plus fluorouracil, leucovorin, and oxaliplatin (NALIRIFOX) demonstrated promising outcomes as a frontline treatment for patients with locally advanced or metastatic pancreatic ductal adenocarcinoma. Findings from a phase 1/2 study (NCT02551991) for 32 patients were presented at the European Society of Medical Oncology (ESMO) World Congress on Gastrointestinal Cancer 2020. The NALIRIFOX regimen resulted in a median progression-free survival of 9.2 months (95% CI, 7.69-11.96) and a median OS of 12.6 months (95% CI, 8.74-18.69). The overall response was 34.4% (95% CI, 18.6%-53.2%), consisting of 1 complete response (CR) and 10 partial responses (PRs).13

An international, randomized phase 3 trial (NAPOLI 3; NCT04083235) exploring the use of frontline NALIRIFOX compared with gemcitabine and nab-paclitaxel (Abraxane) in patients with metastatic pancreatic cancer is now under way.

Other Payloads

Besides chemotherapy, other cancer drugs can be contained within liposomes. Nucleic acidbased drugs, which include oligodeoxynucleotides, plasmid DNA, short interfering RNA, and messenger RNA (mRNA), can be used for gene therapy. However, the use of naked genetic material is challenging due to its large size, instability in the circulation, and susceptibility to degradation by nucleases. Lipid-based carriers offer a way to address these issues.20,21

Bio-Path Holdings is developing prexigebersen (BP1001), BP1002, and BP1003; the latter is still in preclinical testing. All 3 are liposome-encapsulated antisense oligonucleotides that inhibit synthesis of the GRB2, BCL2, and STAT3 proteins, respectively.22-24 Prexigebersen is most advanced in clinical development; Bio-Path recently announced an updated interim analysis of stage 1 of an ongoing phase 2 study in AML (NCT02781883).

Among 17 evaluable patients treated with a combination of prexigebersen and low-dose cytarabine (LDAC), 11 had a response, including 5 CRs.25 Moving forward, patients in stage 2 of the trial will be treated with a combination of prexigebersen, decitabine, and venetoclax, instead of LDAC, following initial safety testing of this combination in which 3 of 6 patients had a response.26

All the currently approved liposomal formulations rely on passive targeting of the tumor tissue through enhanced permeability and retention.9 However, the irregular tumor vasculature thought to be responsible for this effect can also work against effective drug delivery, as can the elevated fluid pressure surrounding the tumor.10,11

To further enhance active tumor-targeted drug delivery, development of functionalized liposomes has also been explored, in which properties of the liposome are engineered for improvements. This includes altering the type of lipid to affect the size or charge of the liposome or conjugating other drugs to the liposome surface. Immunoliposomes, for example, are generated by chemically coupling liposomes with antibodies or antibody fragments against cancer cellspecific antigens, such as EGFR.9,11,18,19

SB05-EndoTAG-1 encapsulates paclitaxel in positively charged liposomes. These are designed to interact with the negatively charged endothelial cells of newly formed blood vessels, releasing paclitaxel into these cells, killing them, and cutting off the tumors blood supply.14 Phase 3 trials are ongoing in locally advanced/metastatic pancreatic cancer (NCT03126435) and triple-negative breast cancer (NCT03002103).

Other types of lipid-based drug deliverysystems, beyond lyposomes, come with advantages and disadvantages. There are several major types of lipid nanoparticles; the lipid core may be solid, liquid, or both, and the core may contain single or multiple compartments of drug, among other distinctive features.8,19

Moderna Therapeutics is developing 2 lipid nanoparticle-based encapsulation systems that contain synthetic mRNAs encoding immunostimulatory proteins.27 Results from an ongoing study of mRNA-2416 (NCT03323398), in which the encapsulated mRNA encodes OX40L, were presented at the 2020 American Association for Cancer Research Virtual Meeting I. Despite being well tolerated, mRNA-2416 had modest antitumor activity, but it is hoped that this may be enhanced by combining it with durvalumab (Imfinzi), a PD-L1 inhibitor. This combination is being evaluated in part B of the study.15

Lipid-drug conjugates (LDCs), in which cancer drugs are linked with lipid molecules, are among the most promising types of lipid nanoparticle. LDCs also can facilitate the loading of hydrophobic drugs into other lipid-based carrier systems.8,28

Promitil is an LDC involving mitomycin-C that is further encapsulated in a pegylated liposomal carrier.16 In a phase 1a doseescalation study, toxicity was lower and dose tolerability higher than historical data for naked mitomycin-C. In the phase 1b portion of the trial in patients with advanced, chemorefractory colorectal cancer, Promitil was evaluated alone or combined with either capecitabine or capecitabine and bevacizumab (NCT01705002).

Among 36 response-evaluable patients, stable disease was observed in 42% at week 12. Median survival was 8.7 months, and adding capecitabine and bevacizumab to Promitil had no further effect. AEs were mostly mild to moderately severe.29

Cellectar Biosciences is developing a different kind of LDC. CLR 131 is a PDC, a proprietary mix of phospholipid ethers (PLEs) covalently linked to a cytotoxic radioactive isotope of iodine-131.3

PDCs offer a lipid-based carrier system with a unique feature: They exploit the altered lipid composition of cancer cell membranes to more actively target tumors. PLEs are naturally occurring lipids that are taken up into cells via lipid rafts, cholesterol-rich regions of the plasma membrane that play a key role in cell signaling. PLEs accumulate in cancer cells, in part because their cell membranes contain an enhanced number of lipid rafts.1,30-32

Thus, the lipid rafts on the surface of cancer cells are bound by multiple PDCs via their PLE moiety. When the lipid rafts eventually undergo transmembrane flipping, they deliver the PLEs and their radioactive payload into the cancer cell. Proposed advantages of this system include the PDCs ability to gain entry into a wide variety of cancer types and indiscriminately target all cells within a tumor without relying on expression of a specific antigen.1

Furthermore, the technology could offer considerable flexibility in the types of payloads that can be used and could be further refined via linker design (Figure 2).1 Cellectar has several other PDCs in preclinical development, including agents designed to produce cell cycle arrest, inhibit protein translation, and disrupt the cytoskeleton.33

CLR 131 has been granted orphan drug status in multiple myeloma, Ewing sarcoma, neuroblastoma, osteosarcoma, rhabdomyosarcoma, and lymphoplasmacytic lymphoma (LPL).34 CLR 131 also has fast track designation for multiple myeloma, diffuse large B-cell lymphoma (DLBCL), and LPL/Waldenstr.m macroglobulinemia (WM).5-7

The most recent fast track designation, for LPL/WM, follows positive results from the ongoing phase 2 CLOVER-1 trial (NCT02952508); Cellectar announced that all 4 treated participants with LPL/WM so far achieved an objective response, with 1 achieving CR.2,7,34

In this trial, patients with relapsed/refractory (R/R) B-cell lymphomas, multiple myeloma, and non-Hodgkin lymphoma (NHL) were treated with 3 doses of CLR 131: less than 50 mCi total body dose (TBD; an intentionally subtherapeutic dose), 50 mCi TBD, and 75 mCi TBD. Patients in both the multiple myeloma and NHL cohorts had a median age of 70 years and were heavily pretreated.34

The overall response rate (ORR) for patients with multiple myeloma (n = 33) was 34.5% across all doses (42.8% at the 75 mCi dose; 26.3%, 50 mCi). In patients with NHL, the ORR among 19 patients was 42% (43%, 75 mCi; 42%, 50 mCi). Subtype assessments demonstrated ORRs of 30% (with 1 CR) in patients with DLBCL and 33% for patients with chronic lymphocytic leukemia, small lymphocytic leukemia, and marginal zone lymphoma. CLR 131 was well tolerated across all dose groups.34

Cellectar simultaneously announced the completion of a phase 1 dose-escalation study of CLR 131 in patients with R/R multiple myeloma (NCT02278315). In this trial, 4 single-dose cohorts were examined (25, 37.5, 50, and 62.5 mCi TBD). The study was modified in 2018 to test fractionated doses (2 doses of 31, 37.5, or 40 mCi TBD, given 1 week apart). For both the single- and fractionated-dose cohorts, CLR 131 was administered as 30-minute intravenous infusions in combination with 40-mg weekly low-dose dexamethasone.34

All patients (n = 17) enrolled in the single-dose cohorts experienced clinical benefit, with 16 participants achieving stable disease. Pooled median OS from the 4 cohorts was 22 months.

Compared with patients administered the highest single dose of CLR 131, the cohort that received the lowest fractionated dose showed better tolerability and safety; despite receiving an 18% higher dose overall, these patients required less supportive care (such as blood transfusions) and had a 50% greater reduction in M protein levels, a surrogate marker of efficacy.34

The next fractionated-dose cohort, which received a total 75 mCi TBD (2 ~ 37.5 mCi TBD; n = 4), had a 50% PR rate, defined as at least a 50% decrease in M protein from baseline. The remaining 2 patients experienced a minimal response, defined as an M protein decrease between 25% and 49.9%.

The authors concluded that CLR 131 showed a clear dose response, with higher doses producing greater efficacy without unacceptable toxicity.35

1. A proprietary platform that specifically delivers oncologic warheads to tumor cells. Cellectar Biosciences. Accessed June 1, 2020. https://www.cellectar.com/technology

2. Cellectar Biosciences announces CLR 131 achieves primary efficacy endpoints from its phase 2 CLOVER-1 study in relapsed/refractory B-cell lymphomas and completion of the phase 1 relapsed/refractory multiple myeloma dose escalation study. News release. Cellectar Biosciences. February 19, 2020. Accessed June 1, 2020. bit.ly/2NZUflr

3. Longcor J, Oliver K, Friend J, Callandar N. Interim evaluation of a targeted radiotherapeutic, CLR 131, in relapsed/refractory diffuse large b cell lymphoma patients (R/R DLBCL). Presented at: 2019 European Society for Medical Oncology Congress; Barcelona, Spain; September 27-October 1, 2019. Abstract 5797. bit.ly/2VMpSDc

4. CLR 131. Cellectar Biosciences. Accessed May 25, 2020. http://www.cellectar.com/product-pipeline/clr-131

5. Cellectar receives FDA fast track designation for CLR 131 in relapsed or refractory multiple myeloma. News release. Cellectar Biosciences, Inc. May 13, 2020. Accessed May 25, 2020. https://www.cellectar.com/news-media/press-releases/detail/206/cellectar-receives-fda-fast-track-designation-for-clr-131

6. Cellectar receives FDA fast track designation for CLR 131 in diffuse large B-cell lymphoma. News release. Cellectar Biosciences. July 9, 2020. Accessed May 25, 2020. https://www.cellectar.com/news-media/press-releases/detail/211/cellectar-receives-fda-fast-track-designation-for-clr-131

7. Cellectar receives FDA fast track designation for CLR 131 in lymphoplasmacytic lymphoma/Waldenstroms macroglobulinemia. News release. Cellectar Biosciences. May 26, 2020. Accessed June 1, 2020. https://www.cellectar.com/news-media/press-releases/detail/238/cellectar-receives-fda-fast-track-designation-forclr-131

8. Alavi M, Hamidi M. Passive and active targeting in cancer therapy by liposomes and lipid nanoparticles. Drug Metab Pers Ther. 2019;34(1). doi:10.1515/dmpt-2018-0032

9. Yan W, Leung SS, To KK. Updates on the use of liposomes for active tumor targeting in cancer therapy. Nanomedicine (Lond). 2019;15(3):303-318. doi:10.2217/nnm-2019-0308

10. Jahan ST, Sadat SMA, Walliser M, Haddadi A. Targeted therapeutic nanoparticles: an immense promise to fight against cancer. J Drug Deliv. 2017;2017:9090325. doi:10.1155/2017/9090325

11. He H, Yuan D, Wu Y, Cao Y. Pharmacokinetics and pharmacodynamics modeling and simulation systems to support the development and regulation of liposomal drugs. Pharmaceutics. 2019;11(3):110. doi:10.3390/pharmaceutics11030110

12. Lancet JE, Uy GY, Newell LF, et al. Five-year final results of a phase 3 study of CPX-351 versus 7+3 in older adults with newly diagnosed high-risk/secondary acute myeloid leukemia. Presented at: 2020 European Hematology Association Virtual Congress; June 11-21, 2020. Abstract EP556.

13. Wainberg ZA, Bekaii-Saab T, Boland PM, et al. First-line liposomal irinotecan 5 fluorouracil/leucovorin oxaliplatin in patients with pancreatic ductal adenocarcinoma: primary analysis from a phase 1/2 study. Presented at: European Society of Medical Oncology World Congress on Gastrointestinal Cancer 2010; July 1-4, 2020. Abstract LBA-001.

14. EndoTAG-1. SynCoreBio. Accessed June 2, 2020. https://www.syncorebio.com/en/focus-area/sb05-endotag-1/

15. Jimeno A, Gupta S, Sullivan R, et al. A phase 1/2, open-label, multicenter, dose escalation and efficacy study of mRNA-2416, a lipid nanoparticle encapsulated mRNA encoding human OX40L, for intratumoral injection alone or in combination with durvalumab for patients with advanced malignancies. Presented at: 2020 American Association for Cancer Research Virtual Meeting I; April 27-28, 2020. Accessed June 1, 2020. Abstract CT032. https://www.abstractsonline.com/pp8/#!/9045/presentation/10742

16. Technology. LipoMedix. Accessed July 5, 2020. http://lipomedix.com/Products/Technology

17. Golombek SK, May JN, Theek B, et al. Tumor targeting via EPR: strategies to enhance patient responses. Adv Drug Deliv Rev. 2018;130:17-38. doi:10.1016/j.addr.2018.07.007

18. Yingchoncharoen P, Kalinowski DS, Richardson DR. Lipid-based drug delivery systems in cancer therapy: what is available and what is yet to come. Pharmacol Rev. 2016;68(3):701-787. doi:10.1124/pr.115.012070

19. Battaglia L, Ugazio E. Lipid nano- and microparticles: an overview of patent-related research. J Nanomater. 2019:1-22. doi:10.1155/2019/2834941

20. Barba AA, Bochicchio S, Dalmoro A, Lamberti G. Lipid delivery systems for nucleic-acid-based-drugs: from production to clinical applications. Pharmaceutics. 2019;11(8):360. doi:10.3390/pharmaceutics11080360

21. Liposomes and lipid nanoparticles as delivery vehicles for personalized medicine. Exelead. November 16, 2018. Accessed June 1, 2020. https://www.exeleadbiopharma.com/news/liposomes-and-lipid-nanoparticles-as-delivery-vehicles-for-personalized-medicine

22. BP1002 (liposomal Bcl2) for follicular lymphoma and other forms of non-Hodgkins lymphoma. Bio-Path Holdings. Accessed June 1, 2020. http://www.dnabilize.com/bp1002/

23. Prexigebersen (liposomal Grb2 antisense) for acute myeloid leukemia (AML). Bio-Path Holdings. Accessed June 1, 2020. http://www.dnabilize.com/bp1001

24. BP1003 (liposomal Stat3) for pancreatic cancer. Bio-Path Holdings. Accessed June 1, 2020. http://www.dnabilize.com/bp1003/

25. Bio-Path announces clinical update to interim analysis of phase 2 prexigebersen trial in acute myeloid leukemia. News release. Bio-Path Holdings. March 6, 2019. Accessed June 1, 2020. http://www.biopathholdings.com/wp-content/uploads/2019/03/BPTH_Press_Release_20190306.pdf

26. Bio-Path Holdings provides clinical update and 2020 business outlook. News release. Bio-Path Holdings. January 8, 2020. Accessed June 1, 2020. http://www.biopathholdings.com/wp-content/uploads/2020/01/BPTH_2020_Business_Outlook.pdf

27. Modernas pipeline. Moderna. Accessed June 2, 2020. https://www.modernatx.com/pipeline

28. Sreekanth V, Bajaj A. Recent advances in engineering of lipid drug conjugates for cancer therapy. ACS Biomater. Sci. Eng. 2019;5(9):4148-4166. doi:10.1021/acsbiomaterials.9b00689

29. Gabizon AA, Tahover E, Golan T, et al. Pharmacokinetics of mitomycin-c lipidic prodrug entrapped in liposomes and clinical correlations in metastatic colorectal cancer patients. Published online January 18, 2020. Invest New Drugs. doi:10.1007/s10637-020-00897-3

30. Deming DA, Maher ME, Leystra AA, et al. Phospholipid ether analogs for the detection of colorectal tumors. PLoS One. 2014;9(10):e109668. doi:10.1371/journal.pone.0109668

31. Weichert JP, Clark PA, Kandela IK, et al. Alkylphosphocholine analogs for broad-spectrum cancer imaging and therapy. Sci Transl Med. 2014;6(240):240ra75. doi:10.1126/scitranslmed.3007646

32. Li YC, Park MJ, Ye SK, Kim CW, Kim YN. Elevated levels of cholesterol-rich lipid rafts in cancer cells are correlated with apoptosis sensitivity induced by cholesterol-depleting agents. Am J Pathol. 2006;168(4):1107-1118. doi:10.2353/ajpath.2006.050959

33. Multi-asset product portfolio for treatment of various cancers. Cellectar Biosciences. Accessed May 25, 2020. https://www.cellectar.com/product-pipeline

34. Annual Report. Cellectar Biosciences. Accessed June 1, 2020. bit.ly/2CwItfO

35. Longcor J, Ailawadhi S, Oliver K, Callander N, Stiff P. CLR 131 demonstrates high rate of activity in a phase 1, dose escalation study in patients with relapsed or refractory multiple myeloma (RRMM). Clin Lymphoma Myeloma Leuk. 2019;19(suppl 10):E356-E357. doi:10.1016/j.clml.2019.09.589

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CLR 131 Leads a New Generation of Lipid-Based Cancer Drug Delivery Systems - OncLive

Super-computer Henry Cavill breaks the Internet again with more geek content – KSRO

Andreas Rentz/Getty Images for Netflix

Andreas Rentz/Getty Images for Netflix(LONDON) While Superman himself,Henry Cavill, already proved his geek bonafides whenhe revealedthat he paints miniatures used in the role-playing gameWarhammer, his latest Instagram post further proved hes a pin-up for the nerd set.

Cavill justposted a video, set to the sexy sounds ofBarry Whites My First, My Last, My Everything, in which themuscled Witcher actor, clad in a tank top, builds a gaming computer from the ground up.

The techy thirst-trap video was too much for some fans to handle. Which gamer girl doesnt dream of a guy like you?one follower commented.

Glad we all agree that the video of Henry Cavill building a pc in a tank top is NSFW, another swooned.

Further evidence that Cavills a bonda fide gamer: inpast interviews, hes confirmed that he missed the call from directorZack Snyderto tell him hed won the part of Superman inMan of Steel, because he was playingWorld of Warcraft.

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Super-computer Henry Cavill breaks the Internet again with more geek content - KSRO

How Equity Is Lost When Companies Hire Only Workers With Disabilities – The New York Times

In December 2017, Ms. Wright was named CNNs Hero of the Year for opening Bitty & Beaus. The award decision received online backlash from disability advocates, who said hiring underrepresented workers should not be viewed as heroic. They also said disabled workers should not be treated as inspirations for merely working a 9-to-5 job like nondisabled people do every day.

When you hire someone, unless they have a special story or something, you arent going to put them in a spotlight and parade them like a mascot, said Courtney Pugh, 23, of Dallas, who has Ullrich congenital muscular dystrophy and lives near Howdy Homemade, an ice-cream parlor that mainly employs people with disabilities. Youre going to hire them, youre going to treat them like the adult they are.

Ms. Wright said the award was more about recognizing the workers rather than herself, though she acknowledged that ideally, businesses like hers would not have to exist if people with disabilities were fully integrated into every workplace.

For right now, this seems to be a step in the right direction, and its making people rethink what the workplace looks like and what people with disabilities are capable of doing, she said

With devastating job losses because of the pandemic, advocates said this was the time for people with disabilities to be given the chance to pivot away from industries they had been traditionally boxed into and transfer their skills to other sectors.

Alexandra McConaughey, a multiply disabled law graduate, said the job market was so abysmal that it was understandable why disabled workers would choose to work at a company like SAP or Bitty & Beaus.

Im someone whos experienced a lot of hiring discrimination, so I see the appeal of knowing that the people on the other side are actually genuinely looking for disabled talent, said Ms. McConaughey, who was recently hired to work as an associate at a nonprofit law firm. Honestly, if I hadnt gotten this job, Id be looking for those types of initiatives right now, because getting a job as a person with a disability is so hard.

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How Equity Is Lost When Companies Hire Only Workers With Disabilities - The New York Times

Earth may have lost half of its atmosphere to create Moon, reveals study using 3D videos – Republic World – Republic World

How would a collision of some celestial object with Earth look like? Will ourplanet shatter into millions of pieces of space debris or be torn into larger objects.

It might be hard for some to imagine but certainly not for researchers and space geeks at Durham University who havenow used advanced 3D computer simulations toshow how Earth-like planets with thin atmospheres might have evolved in an early solar system depending on how they are impacted by other objects.

Astronomers in the Institute for Computational Cosmology, Durham University, conducted the simulations on the COSMA supercomputer and used the SWIFT open-source code, largely developed and maintained at Durham, to enable the running of these high-resolution supercomputer simulations.

The findings provide greater insight into what happens during these giant impacts, which scientists know are common and important events in the evolution of planets both in our solar system and beyond.Using 3D supercomputer simulations, the researchers have found a way of revealing how much atmosphere is lost during these events.

The researchersran more than 100 detailed simulations of different giant impacts, altering the speed and angle of the impact on each occasion. They found that grazing impacts like the one thought to have formed our Moon 4.5 billion years ago led to much less atmospheric loss than a direct hit.

READ |Does The South Atlantic Anomaly Suggest That Earth's Magnetic Poles Could Flip? Find Out

READ |Comet, Asteroid & Meteoroid Flying By Earth In 2020; Know How They Differ From Each Other

Head-on collisions and higher speeds led to much greater erosion, sometimes obliterating the atmosphere completely along with some of the mantle, the layer that sits under a planets crust.

Using the results, the study estimates thatEarth got lucky with its collision that created the Moon. The impact only managed to wipe out between 10% to 50% of its atmosphere.

"In spite of the remarkably diverse consequencesthat can come from different impact angles and speeds, we'vefound a simple way to predict how much atmosphere would be lost, said the lead author of the study, Dr. Jacob Kegerreis.

The studywill help scientiststo understand both the Earths history as a habitable planet and the evolution of exoplanets around other stars. The researchers are carrying out hundreds of more simulations to test the effects that the different masses and compositions of colliding objects might have.

READ |Asteroid 2002 BF25 Will Pass Very Close To Earth's Orbit On July 21: NASA

READ |NASA News: Asteroid The Size Of London Eye Will Soon Pass Very Close To Earth's Orbit

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Earth may have lost half of its atmosphere to create Moon, reveals study using 3D videos - Republic World - Republic World

Local golf league results and upcoming events – The Ledger

Results from golf league play around Polk County through July 20.

Results from golf league play around Polk County through July 20 with format, date, event and winners by flight or class in alphabetical order.

Big Cypress 18-Hole Ladies, Nine-Hole Event, Low Gross/Net, July 14: First Flight Gross - Heidi Aittama 34, Jan Turner 39, Net - Jennifer Renaud 34, Joanne Burkemper and Diana Berube both at 36; Second Gross - Anne Merritt and Jennifer Hostutler tied at 45, Net - Barb Fatzinger 33, Linda Kimberlin 34. Closest to pin: No. 5 - Heidi Aittama plus 2-19 HDCP, Linda Kimberlin 20+ HDCP.

Big Cypress Men's Thursday, Three Clubs and a Putter, July 16: First Flight - Joe Greco 72, Eddie Kiena and Ray Berube tied at 74; Second - Mike Schaeberle 73, Bob Chapman 75, Arnie Howard 73. Closest to pin: No. 5 - Joe DAmbrosio, Bob Chapman; No. 8 - Timmy Monahan; No. 13 - Ray Berube; No. 15 - Eddie Kiena, Eddie Lane.

Cleveland Heights Tuesday Men's, Draw and Quota Points, July 14: Herb Koffler/Dave Neal/Steve Criss plus 6, Keith Lohman/Paul Pelchat/Ron Moisuk plus 3, Mike Mimnaugh/Ron Berry/Dick Gebo plus 2. Closest to pin: No. A2 and C8 - Dennis Compton. Best Over Quota: A - Herb Koffler plus 6; B - Keith Lohman plus 5; C - Dave Neal plus 2.

Eaglebrooke Men's Early Morning Group, July 18: Team Best vs Average Score, July 18: Paul Rouleau/Mike Gilbert/Richard Grant/Tyler Wright minus 5.7, Wayne Fugett, Paul Meyer, Ladd Kline, Al Hanif minus 3.7. Team Point Quota, July 19: Smith Patterson/John Johnson/Kyle Thomas/Jeff Lang and Dan Girata/Albert Sagnella/Richard Grant/Tony Autorino tied at plus 11.

Hamptons Men's, Net Stroke Play, July 14: A Flight - Chuck Swafford 50, Joe DeBonis 54 on a match of cards over Bill Spivey; B - Terry Foster 54, Bob Miller 55, Bill Colclaser 57. Closest to pin: No. 5 - Joe DeBonis; No. 10 - Mark Torr.

Lake Ashton Blue Man Group, Four-Player Team, Best Net on Par 4s, Best Two Nets on Par 5s, Best Three Nets on Par 3s, July 15: Front 9 - George Wilkinson/Larry Griffin/Jim Fish/Ed Costello 36, Doug Stanforth/Ron Watterson/Gary Robillard/Ghost 39, Gator Patrick/Tom Anderson/Jim Smith/Nolan Hake 41; Back 9 - Joe Ricobonno/Steve Burrell/Bob Yeager/Ron Mckie 43, Jim Blackwell/Rich Burns/Jerry Getters/Mike Costello and Ken Engh/Art Luke/Jim Jameson/Norm Wirtala tied at 45.

Lake Ashton Ladies 18-Holers, Four Player Scramble, July 14: First Flight - Mafie Walker/Janis Vasquenza/Lynne Abbott/Marie Clauser 53.3, Colette McKie/Cheryl Coveleskie/Margaret Volpe/Pat Hodges 54, Cheryl Winchester/Mary Anne Stadfeld/Carole Ferrieri/Jackie Tressler 54.2.

Lake Ashton Ladies Niners, Four-Player Scramble, July 14: Carolyn Alvaro/Ann Lake/Diane Struble/Liz Meigel and Carol Zalesky/Brenda Arant/Carol Gillespie/Loretta Hieronimus tied at 25, Laverne Anderson, Linda Ford, Jane Poole, Missy Prescott 26.

Lake Ashton Men's, Two Best Nets Even Holes Plus Three Best Nets Odd Holes, July 15: Chuck Randall/Ron Mcdonnell/Mike Krigelski/Randall Carpenter 164, Rolly Geyer/Jim Capra/Tim Prokop/Jim Ford 165, Larry Wilson/Ted Hall/Don Connors/Courtney Smith 167.

Lake Bess 7 a.m. Tuesday Mens Scramble, Random Team Draw, July 14: Tom Houston/Pat Ferrio/Henry Adams/Joe Gulini minus 5. Closest to pin: No. 7 - Mark Detrick.

Lakeland Elks Lodge 1291 Monday League, Wedgewood, July 20: A Flight - Jim Preston plus 5, Bob Kutsch plus 4 on a match of cards over Carl Hatfield, B - Bill Soldrich plus 4 on a match of cards over Bob Fuschetti and Mike Powell. Closest to pin: No. 8 (50/50) and No. 15 - Bill Soldrich.

Ridge Men's, Wedgewood, July 16: Paul Forkner plus 5, Bobby Lassiter plus 3, Dob Smith and Dennis Johnson tied at plus 1. Closest to pin: No. 4, 11, 17 - Blake Tyler; No. 6 - Dob Smith.

Schalamar Creek Couples', 4 Person Scramble (9 Holes), July 15: First Flight - Richard Romero/Linda Romero/Glen Valentine/Ginger Valentine 34, Ted Reid/Ginny Reid/Don Taft/Kathy Taft 35.

Schalamar Creek Ladies', Low Gross/Low Net (9 Holes), July 14: First Flight Gross - Crystal Santopadre 50, Dianne Lang 52, Linda Romero and Carol Sutton tied at 38.

Schalamar Creek Men's, Two-Man Best Ball, July 13: Clayt Liljequist/Paul Loftis 59, Jim van DeVelde/Larry Smith and Greg Spencer/Glen Valentine tied at 61; Second - Jerry Throgmorton/Terry Phalen 56, Joe McElhenny/Don Gledhill 57, Don Abbott/Ed Herring 62.

TOURNAMENTS & LEAGUES

BARTOW INDIVIDUAL POINTS, Wednesdays, nine holes, make up your own foursome, $17 ($12 green fee and cart), pays all plus scores, night specials in the lounge. Call 863-533-9183.

CLEVELAND HEIGHTS MENS, tee times available 7:30-8:30 a.m. Wednesday through Monday and Friday, groups or individuals welcome, quota points with skins optional, eight to 10 groups now play. Call Paul Boeh at 863-738-4129.

CLEVELAND HEIGHTS TUESDAY WOMENS, every Tuesday, tee times start at 8:30 a.m. Call Shirley Kalck at 863-853-9566.

HUNTINGTON HILLS TWO-ASIDE, Saturdays, 18-Hole Points Quota. Check in by 8:15 a.m. Contact Terri White at 863-5594082 or eagle-2par@aol.com.

HUNTINGTON HILLS WHY WORRY WEDNESDAYS, Nine-Hole Quota Points, 5:15 p.m. shotgun start. Contact Terri White at 863-559-4082 or eagle-2par@aol.com.

LAKELAND MENS SENIOR GOLF, 7:30 a.m. shotgun starts, play against golfers within your handicap. Call Ed Young at 863-648-9695.

LPGA AMATEUR GOLF ASSOCIATION is looking for women and men to play in weekly Wednesday league and every other Saturday at various courses in the Winter Haven/Lakeland/Orlando and other areas. For more information, email Kathy Mannahan at pjacobs21@tampabay.rr.com.

POLO PARK MENS TUESDAY SCRAMBLE, 7:30 a.m. sign in. Random team draw. 18-Hole. For more information, call Polo Park Pro Shop at 863-424-3341.

POLO PARK MENS SATURDAY SCRAMBLE, 7:30 a.m. sign in. Random team draw. 18-Hole. For more information, call Polo Park Pro Shop at 863-424-3341.

RIDGE MENS THURSDAY QUOTA POINTS TOURNAMENTS, 7:30 a.m. tee time starts. Call Carroll Lasseter at 863-299-5350.

WEDGEWOOD THREE-MAN SCRAMBLE, nine holes; Tuesdays at 5 p.m.; call Marcus at 863-858-4451 by 2:30 p.m. to play.

WEDGEWOOD TWO-ASIDE GAME, 9 a.m. on Wednesdays and Fridays; 18-hole points game with skins and blind draw; call Marcus at 863-858-4451.

WEDGEWOOD MIXED CO-ED SCRAMBLE, 2 p.m. Thursdays. Call Marcus at 863-858-4451 by 1 p.m. to play.

E-mail results of local golf tournaments, aces and upcoming tournaments to mquinn@theledger.com; or mail to Golf News, Ledger Sports Department, P.O. Box 408, Lakeland, Fla., 33802. Include complete scores and league names. Deadline is Monday at 5 p.m.

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Local golf league results and upcoming events - The Ledger

Big Crypto Hacks: Bad Crypto News of the Week – Cointelegraph

It has been all over the news about the great Twitter Bitcoin hack of 2020. Weve got you covered if you havent been paying attention to #CryptoTwitter this week.

After a period of calm in the cryptomarkets, last week showed some movement. Unfortunately, it went in the wrong direction. Bitcoin was down about 3 percent over the last seven daysand it got off lightly. Ethereum fell more than 5 percent and Bitcoin Cash dropped over 8 percent.

One reason for the fall might be a relationship between stocks and digital coins. Analysts note that Bitcoin shows a 95 percent correlation with the S&P 500, and the Fear and Greed Index suggests that greed is moving the stock market while fear is holding onto cryptocurrencies.

There has been plenty of movement and in different directions: Tesla stock is rocketing even as Bitcoin volatility hits a three-year low. Binance coin has risen 17 percent. Other analysts suggest that a crypto winter could be over as take-up of digital coins increases, especially those with proof-of-stake protocols, but the data says that people are holding onto Bitcoin but trading Ether.

People should certainly be holding tightly onto their Bitcoins when theyre using Twitter. A massive hack of the social media platform placed scam messages on the accounts of Elon Musk, Kanye West, Bill Gates, and Joe Biden among others. The messages asked for donations of Bitcoin and promised a 2:1 return. Reports suggest that victims sent around $118,000 worth of Bitcoin to the address in the posts.

One set of transactions, though, contained a hidden message apparently suggesting that the scammers use Monero instead of Bitcoin. The hackers appear to be associated with the now-defunct website CryptoforHealth.com but we still dont know who was behind it. Justin Sun wants to find out. His was one of the accounts hacked. Hes offering a million dollars to anyone who can help track them down.

He probably shouldnt give that million dollars to Joshua Thomas Argires though. The 29-year-old Texan is alleged to have filed false loan applications worth $1.1 million to the Covid-19 Paycheck Protection Program. He then used the funds to buy cryptocurrency. Argires has been charged but he should count himself lucky.

The bodies of two promoters of the OneCoin scam have been found in suitcases in Mexico. The men, Oscar Brito Ibarra and Ignacio Ibarra, had been kidnapped and suffocated to death.

While Joe Biden scratches his head over the Bitcoin Twitter hack, Ron Pauls political director is quietly mining Bitcoin and building a new blockchain company. In China, the central bank is considering allowing the Tencent delivery giant Meituan Dianping to accept digital yuan and Japans giant financial institution, Mitsubishi UFJ Financial Group, is planning to release a token later this year.

OKEx CEO Jay Hao is continuing to insist that Dogecoin is serious despite the recent TikTok pump scheme. Its not just Twitter that struggles with cryptoscams.

Check out the audio version here:

Joel Comm is an internet pioneer, New York Times best-selling author, futurist speaker and co-host ofThe Bad Crypto Podcast. Thats a fancy way of saying he writes words, says things and loves to play with cryptos

The views, thoughts and opinions expressed here are the authors alone and do not necessarily reflect or represent the views and opinions of Cointelegraph.

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Big Crypto Hacks: Bad Crypto News of the Week - Cointelegraph

Are Chicken Wings A Meal? Is The New Is A Hot Dog A Sandwich Thanks To NY Governor Andrew Cuomo – BroBible

New York governor Andrew Cuomo has never been the most popular guy in the state since he was elected in 2011, and while he managed to beat Miranda from Sex in the Citywhen she staged a primary challenge in 2018, he didnt exactly inspire a ton of confidence when he failed to legalize marijuana the following year despite vowing it was all but a done deal.

He made it illegal to declaw cats though, so, um, I guess thats something.

Weed was expected to actually pass earlier this year but that legislation ultimately never materialized, which is fairly understandable when you consider there was a slightly more pressing matter in the form of the pandemic that crippled the state back in March.

There are plenty of people whove criticized Cuomo and other officials in New York for not taking preventative measures that couldve mitigated the crisis that eventually unfolded, but regardless, he was widely praised for how he handled the situation and his daily press briefings received national attention as his efforts helped New York slowly but surely flatten the curve.

Cuomos approval rating reaped the benefits of his actions, as hes more popular than hes ever been during his nine years as governor.

However, he seemsincrediblyintent on shedding some of that goodwill based on some questionable decisions hes been making over the past week.

As someone who was lucky enough to be sharing an apartment with a nurse in New York City when the shit hit the fan, trying to find positives in the situation was like combing through the pit full of needles inSaw II.However, one upside eventually appeared when bars started offering drinks that werent technically legal to drink in public but just so happened to be served in a plastic cup and with a straw. In addition to making the depressing new reality a bit more bearable, it also allowed you to support businesses in need of all the help they can get during uncertain times.

I personally havent experienced any issues, but there have been more than a few instances where large groups of drunk, maskless assholes have been observed congregating outside drinking establishments. In an attempt to address the issue, Cuomo went down a very interesting route last week when he issued an edict requiring food to accompany any alcoholic beverage thats ordered.

If he had put even two seconds worth of thought into that decision, he wouldve realized there was a loophole the size of a Star Destroyer, and bars and restaurants around the state responded by whipping up custom menus offering food items for as little as a penny to comply.

As a result, the State Liquor Authority scrambled to crack down by attempting to define the types of items that are acceptable. At first, it issued new guidelines that specified sandwiches, soups, or other foods, whether fresh, processed, precooked or frozen. After realizing the inclusion of other foods nullified the entire thing, it clarified it intended to refer to foods which are similar in quality and substance to sandwiches and soups, citing salads, chicken wings, and hot dogs as examples of items with enough quality and substance.

Welp, it appears no one told Cuomo about that, as things officially went off the rails during a press conference on Thursday where he attempted to do some clarifying of his own and failed spectacularly, as he made a number of baffling claimsthe most notable of which is that chicken wings are not substantive food.

Theres a lot to process here, as Cuomo opened up his statement by suggesting all bars were equipped to sell soup, sandwiches, etcetera (thats not how etcetera works!) prior to the pandemic. This simply isnt true, as there are plenty of places that offer free popcorn and literally nothing else. He then proceeds to call out not just hors doeuvres but chicken wings in particular, which I take as a personal attack. He then caps all of this off by defining the lowest level of substantive food as sandwiches, meaning he either A) contradicted his first point 15 seconds after making it or B) seems to think soups are somehow a heartier option.

I had a brief Ron Paul phase back in high school but I would not describe myself as a libertarian. However, how can you possibly think this is remotely acceptable? I know Cuomo has a long history of telling people that he knows whats best for them and covering his ears and going LA LA LA, CANT HEAR YOU! if they object, but this is insane.

Why is the governor of a state telling me what is and isnt food? Have I actually been doing everything wrong my entire life? Like, I thought my stomach has done a pretty good job telling me that Im full after crushing a dozen wings and two pitchers of beer in an unhealthy amount of time but perhapsits been lying to me? Fuck, man. Fuck.

Also, Im sure this will go over really well with his constituents in Buffalo. Hey, guys. You know that food that is the only thing your city was known for before people started jumping through flaming tables at Bills games? Get thisits not food!

I didnt really think 2020 could get any dumber and now theres a very real chance a judge is going to have to tell us which foods are foods. What a world.

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Are Chicken Wings A Meal? Is The New Is A Hot Dog A Sandwich Thanks To NY Governor Andrew Cuomo - BroBible

Cryptocurrency and Politics: Government Officials Supporting the Industry – Coin Idol

Jul 24, 2020 at 12:09 // News

While many countries lack strong and clear legislation for the cryptocurrency industry, some politicians arent frightened of expressing their support for virtual assets.

It has been more than a decade since the first cryptocurrency came into existence, but most politicians still associate it with high risks, especially after Facebook revealed its plans to launch the Libra project. However, since the financial regulators and the general public are becoming more aware of the decentralized technologies, politicians tend to take a closer look at this nascent industry.

Politicians such as the Prime Minister of Israel Benjamin Netanyahu, Venezuelan President Nicolas Maduro, President of Uganda Yoweri Kaguta Museveni, South Koreas minister of science, Information and Tech Yoo Young-min, Iranian President Hassan Rouhani, H.E Tayyip Erdogan the President of Turkey, Prime Minister of Malaysia Tan Sri Muhyiddin Yassin, are well-known enthusiasts of virtual currency.

In 2018, H.E. Museveni advised Bank of Uganda (BoU) governor Prof. Emmanuel Tumusiime Mutebile to stop being "dogmatic" and start focusing on how to integrate blockchain and cryptocurrency in payment systems at the national level.

During the Kuala Lumpur Summit in 2019, President Rouhani and other top officials from Qatar, Turkey, Iran and Malaysia, called for strong Muslim teamwork on cryptocurrency if they want to end the US hegemony. In May this year, H.E. Rouhani also instructed the financial regulator and legislators to quickly formulate a national cryptocurrency mining strategy.

President Maduro developed a state-owned cryptocurrency Petro and circulated it to the citizens for use. In April 2020, as per CoinIdol, a world blockchain news outlet, Maduro was trying to promote cryptocurrency by giving one free Petro to every medical worker who risks her or his life combating the spread of coronavirus disease. He also ordered citizens who are trying to process their passports and visa to always pay the fees using Petro.

Also, the former political director for the Ron Paul 2008 presidential campaign, Craig Berman, a Libertarian, is mining BTC as a side project beside politics, under his firm called Vortex Blockchain Technologies. Craig is a longtime enthusiast of BTC and claims he sturdily backs cryptocurrency over the fiat currency including the USD.

Andrew Yang, a US Democrat politician who wanted to represent his party in the 2020 presidential election is also bullish on BTC. Yang and his team were accepting cryptocurrencies such as Bitcoin and Ethereum in donations intended to raise funds to help him facilitate and run his campaign. In April 2019, Yang called for cryptoasset regulatory clarity to help businesses invest in blockchain-related innovations without being wary of regulatory shifts.

Reputable legislators of South Korea, Sweden, the United Kingdom, Singapore, the United States, Lichtenstein, Lithuania, Switzerland, the Netherlands, Venezuela, Japan, etc., have also not hidden their support for cryptocurrency and distributed ledger technology (DLT) adoption.

There are many other politicians who support a greater Bitcoin and blockchain adoption in the future. For instance, the US Congressman Jared Polis argued in March last year that the US dollar should be banned instead of outlawing the flagship cryptocurrency BTC. The congressman is actively working to wade the governments potential efforts to slow down the growth of cryptocurrency.

Also, the Republican Andrew Hemingway who is running as a Governor in New Hampshire, supports DLT and cryptocurrency-related techs. He actually believes that DLT, the underlying tech behind Bitcoin, could be applied in voting IDs if a more transparent online voting for overseas valid voters is to be achieved.

Australian political leader, Nick Dametto, has also been publicly discussing cryptoassets. A Chinese political bull, Wang Pengjie, has called for rolling out an effective cryptocurrency trading platform nationally. In 2018, Prince Hamdan Bin Mohammed of Dubai also rolled out a DLT strategy.

George Galloway, a Mayoral candidate for London, plans to leverage DLT and use it to track Mayor of Londons expenditure in order to have unmatched transparency. This technology behind Bitcoin can help offer a high-tech backbone for true, 100% transparency.

The opinions and participation of these politicians could positively change a lot of things as the entire globe is ready for yet another high-tech innovation. But the biggest question still remains whether these politicians that are cryptocurrency enthusiastic will lobby the regulatory-friendly position if they are still engaged in politics.

Many of these politicians, especially the incumbents, have got the power and capacity to influence the amendment of the financial laws governing their respective countries so as to include, legalize and accept cryptocurrency to operate within their territories.

Those candidates aspiring to enter developmental politics to effectively serve their people, will bring in new ideas about this promising sector. Some of the ideas could be how best can these cryptocurrencies be regulated, how can these digital currencies be used without weakening fiat currencies, how best can illegal activities related to cryptoassets be combated, etc.

When a levelled ground has been finally built for the blockchain businesses in many countries across the globe, cryptoasset firms and adopters will be using the available legal framework to trade (buy and sell) digital currencies. This would mean that the market and the adoption range of blockchain and other decentralized technologies such as smart contracts will increase and the cryptocurrency industry will also see significant growth in the near future.

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Cryptocurrency and Politics: Government Officials Supporting the Industry - Coin Idol

Deutsche Banks Top Credit Strategist: I Am A Gold Bug. Fiat Money Is A Passing Fad In The History Of Money – Moguldom

Written by Dana Sanchez

Jul 23, 2020

Gold is having a good week withprices continuing to push higher while the U.S. dollar is pushed downward, stoking demand for anti-fiat alternatives.

Optimism about a global economic recovery has been overtaken by renewed fears over record-breaking new U.S. coronavirus cases.

Top Deutsche Bank strategist Jim Reid recently described himself as a gold bug, Goldseiten.de reported. Gold has seen extraordinary increases so far this year at a time of high global risk while central banks have worked in full rescue mode, according to Reid.

Reid said he thinks that fiat money will be a passing fad in the long-term history of money unusual tones for a renowned banker, Goldseiten reported.

Reid added that he thinks Gold is definitely a fiat money hedge and more importantly, a transition asset to whatever monetary system is next.

This isnt the first time Reid has predicted global realities may soon put the current fiat-money regime to the test. In 2017, Reid said the fiat currency system a term which describes any currency whose value is backed by the government that issued it, rather than by a commodity like gold or silver could be seriously tested over the next decade, Business Insider reported.

The U.S. dollar was convertible into gold until the mid-1930s, and was tied to the value of gold until the early 70s, when President Richard Nixon severed the relationship between the U.S. dollar and gold. As a result, inflation became less volatile, and deflation became a non-issue except in the oil crisis and recession of the late 1970s and early 1980s. With more flexibility to control supply and demand of currency, the Federal Reserve can limit the impact of major economic shocks.

Critics of gold advocates often use the argument that fiat currencies arent really worth anything since there isnt anything tangible that underpins its value, Jason Hall reported for The Motley Fool. Thats really not a very accurate description of a fiat currency, versus a gold standard. Simply put, the value ofanycurrency, whether a commodity or a fiat currency, is only relative to what peoplethinkits worth.

Reid admitted that with the exception of gold, he has always found many commodities difficult to recommend on a buy and hold basis as most underperform inflation over the long run probably as they are mostly used in production and alternatives are found if too expensive. We also become more efficient at using them.

Reid noted that between 1860 and 1971, the real price of gold fell by 75 percent. Since then, gold is up seven times, double its 1860s real level.

Central banks actively buoy up equities, whereas gold has been repeatedly knocked by monetary authorities, so its performance is impressive considering it has had to fight the Fed for almost 40 years.

Listen to GHOGH with Jamarlin Martin | Episode 73: Jamarlin Martin Jamarlin makes the case for why this is a multi-factor rebellion vs. just protests about George Floyd. He discusses the Democratic Partys sneaky relationship with the police in cities and states under Dem control, and why Joe Biden is a cop and the Steve Jobs of mass incarceration.

Gold is not a typical investment, former Rep. Ron Paul wrote in a 2010 guest column entitled Heres Why Governments Hate Gold.

It is a defense against the predictable behavior of governments to debase a fiat currency under its absolute control. The people who run the printing presses have trouble shutting them off.

Reid contended in 2017 that the fiat currency systemis inherently unstable and prone to high inflation. He wrote a paper discussing the start of the end of fiat money.

Deutsche Bank isnt known for its gold bugs, but that hasnt stopped its strategist, Thomas Colson wrote for Business Insider at the time.

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Deutsche Banks Top Credit Strategist: I Am A Gold Bug. Fiat Money Is A Passing Fad In The History Of Money - Moguldom