Does it Hold Up? Ghost in the Shell: Stand Alone Complex – Anime News Network

The term Stand Alone Complex can be loosely defined as a social phenomenon where unconnected actions combine to create a group effort, though it isn't maintained by a ringleader or ruling body. It propagates without instruction or leadership, with random humans moving toward a collective goal without conscious intent, eventually becoming a coherent whole. Essentially, in the words of the Stand Alone Complex fandom wiki, One could say that the Stand Alone Complex is mass hysteriawith purpose.

While we have all been swept up in mass hysteria at one point or another, for a galaxy of different reasons, what can be said is that when the momentum gets going, there's fairly little anyone can do to stem the tide. We can easily equate this to a stampede. When enough participants get spooked and start charging, even if there is a sizable amount of protest from within their ranks, the whole mob will run clear off a cliff without hesitation.

But what makes mass hysteria unique, is the many forms in which it can appear. My favorite example of this is the Strasbourg Dancing Plague of 1518, where anywhere from 50 to 400 people inexplicably danced in the street for the better part of two straight months (though there is considerable debate over who actually kicked off this flash mob, and if the rumors of a dozen or more people dying each day were simply made up). While intense speculation has persisted in the centuries since, based on the collected records from documentarians, there has never been a definitive explanation for what happened.

Another well-known example of mass hysteria came packaged as the infamous Satanic Panic (which took root in the 1980s and has never really gone away). This mass reporting of unsubstantiated cases of ritualistic abuse, trafficking and sacrifice has come to include tens of thousands of investigations throughout the world over the decades. Not a single one has confirmed the existence of these ritualistic cults engaging in satanic sadism. Yet, the panic remains entrenched in international culture and rhetoric, with little sign of ever fully dissipating.

However, when we recognize a Stand Alone Complex, the results can get fairly more complicated. Probably the best modern example which could be classified as this phenomenon is the decentralized hacktivist movement, Anonymous. The emergence of these self-identified vigilantes utilizing the ambiguous moniker became news in 2007. The one-two punch of online predator Chris Forcand's arrest in Canada, and the 2008 launch of Project Chanology against the Church of Scientology threw this movement onto the world stage. In the succeeding years, in the wake of continued activity and notoriety, investigations from journalists, and international law enforcement and intelligence bureaus continually prove that Anonymous members can operate entirely exclusive of one another if they desire it. And fun fact, when I was 18, I actually attended a few protests supposedly organized by Anonymous. But to the actuality of that, I only have assumptions since the organizers were faceless online, and masked in person.

It is quite difficult to prove that these actions were the work of a loose collective, or whether random people are throwing a label on their movements as a means of brand recognition in order to legitimize their actions in the eyes of some, and to possibly cover their actual tracks. Anonymous has come to be used in music, television, and merchandise to a degree that it is now an indelible part of our collective culture, for better and for worse (depending on your stance towards them).

But the main point that I am driving at is that Anonymous now exists as an entity which is self-sustaining, fueled by our contrasting idealism and hysteria, and continues to survive merely by the weight of its cultural impact. Whether or not those who claimed allegiance to their collective are still active, or ever were, many see the publized actions of the group as all the evidence they need in order to believe in their existence and efficacy. While others will maintain stark skepticism for the very same reasons, maintaining that private organizations, government branches, or individual power players are using the zeitgeist in order to manipulate and misdirect public opinion and information.

This uncertainty towards a shadowy entity on the periphery of our society, manipulating its many tiers, is exactly the framework which is utilized within the classic anime series, Ghost in the Shell: Stand Alone Complex. Based on the 1989 manga by Masamune Shirow, as well as the 1995 Mamoru Oshii feature film, Stand Alone Complex is an original adaptation by Kenji Kamiyama which is set in an alternative storyline to that of its source material. While it still utilizes many of the same characters, settings, and designs, it manages to inject a considerable amount of original material into the existing ethos of the Ghost in the Shell universe.

Ghost in the Shell: Stand Alone Complex mostly takes place in Japan during the years 2030 and 2032. After humanity develops the ability to cyberize themselves, utilizing prosthetic body parts and cybernetic brains, the boundaries between what is human and machine is ever more blurred. The proof of humanity against artificial constructs usually boils down to someone's possession of a ghost, or essentially the concept of the human soul. In the wake of society evolving and restructuring around this massive singularity event, we follow Public Security Section 9, a clandestine counter-cyberterrorism squad of former military and police personnel, who are responsible for mitigating threats which cannot be handled by mundane security efforts. Through their normal activities, they uncover widespread and amorphous conspiracies which pose threats on an international scale. Though paradoxically, the closer they get to the truth, the more dangerous and untenable their situation becomes.

The series is largely set in the fictional Japanese city of Niihama, and follows Section 9 through two major cases which threaten to unsettle Japan's balance between its population and its government: The Laughing Man and the Individual Eleven. While there exists considerable overlap, as well as wide divides between these cases, for this video, we're going to focus on the former case.

The Laughing Man is an enigmatic hacktivist reportedly responsible for the largest acts of cyberterrorism in modern Japan, where numerous corporations were hacked and blackmailed. Unaware whether The Laughing Man is a domestic or foreign terrorist, or even if it's a solo hacker or a team, the police have chased this ghost for six years with little to show for it. Togusa, the rookie of Section 9, is contacted by an old friend still investigating the case. In the wake of his friend's mysterious car accident, Togusa discovers police corruption involving illegal internal surveillance of its officers. When the scandal breaks, a police press conference publicly denying responsibility is called, blaming the head of The Laughing Man task force. But before reporters can press the personal ties to the nanomachine company responsible for the surveillance equipment at the heart of the scandal, The Laughing Man hijacks a police official's cyberbrain, denouncing the police response as a farce, and threatening the Superintendent-General's life.

The following night, an attempt is made on the life of the Superintendent-General when a security chief is brain-hacked, followed by a close series of apparent accomplices attempting to finish what the hacked goon could not. While a virus is blamed for the initial attempt, it is soon apparent that all of the succeeding individuals operated entirely on their own volition, with no link to one another or the previous crimes. While the public is quick to be swept up in the fervor when a fall guy is named posthumously as The Laughing Man, Section 9 unravels a sizable conspiracy that the government was doctoring evidence and using The Laughing Man as a means to control public opinion while they work with private corporations to profit off of human misery.

The Laughing Man is seen as both a vigilante hero and a public menace throughout nearly every echelon of society who look from the outside-in. His iconic logo is utilized in art, and on merchandise. His name is evoked in the fiery rhetoric of those wielding public platforms and open forums. While the perpetrator of the more televised actions which fast-tracked the whole Laughing Man frenzy is revealed to be a man named Aoi, whether this persona was born from a real activist attempting to change society, or was always a farce created to manipulate the masses, in the world of Stand Alone Complex, it's rather a moot point. His place in the culture, and as a means for motivation to pursue similar courses of action, is set deep within Japan's social landscape. This makes the public reactions to his supposed rhetoric and acts of terrorism even more dangerous, because there is nothing to precipitate what people will do, when they will do it, and for what purpose. This uncertainty provides a perfect opportunity for powers in a position to manipulate the image of The Laughing Man. The rest of us will believe what we will, and will act accordingly. As a result, hysteria spreads, the truth is buried, and the world keeps on turning.

Now, the metatextual origin of The Laughing Man initially came from the short story of the same name, written by American author J. D. Salinger. And even if you haven't read the story, or any of Salinger's works, on top of multiple references to his writing through casual conversations, the character Aoi is highly influenced by Holden Caulfield, the protagonist of The Catcher in the Rye. Now, I am certainly not a fan of Salinger, and I have mentioned this a few times in other videos, and there are a lot of reasons why I keep anything he wrote at arm's length. But the surprising thing with Holden's motivations and qualms with the world around him, a facet of his character that has caused immense irritation, is that when Aoi takes hold of the same principles, there are two key differenceshe is proactive, and he manages to mature.

Holden is a passive character, and a perpetually immature one. He is a teenager, cursing the adult world for its harshness, monotony, and greed, which influences his views on what is important in life. But Aoi tries his damnedest to do the right thing in the wake of such inhumanity; he wants to change the world for the better. He wants to embrace the idea that innocence and solidarity are innate concepts within human society, which need to be fostered and protected. As he aged, with his moniker hijacked by those seeking to exploit others, and those he sought to bring down still operating behind the scenes, he sees the work of Section 9 as a fastlane to finally accomplish what he set out to do all those years ago. And get used to a lot of literary references, because the whole cast of Stand Alone Complex is extremely well read (as if they all were going for a graduate degree in literature).

Every installment in the Ghost in the Shell franchise is buried under an avalanche of overarching themes and visual motifs, wearing many of its influences right on its sleeve. While mostly this comes around as more debates over life when artificial intelligence is nearly identical to organic intelligence, the focus on a Stand Alone Complex and its implications for a society is thoroughly unique. And even though SAC just passed its 19th birthday, its relevance is more prevalent now than ever before. We exist in a world of hyper-charged ideological battlefields and cultural friction, with hysteria continuing to pressure public policy and mob mentality. We live in an age where stand alone complexes such as Anonymous are bound to increase exponentially, regardless of who may be seen at the helm. When we eventually reach our next singularity point, these complexes will only compound the considerable change our worldwide civilization will undergo and settle into in the coming generations. Nothing truly occurs within a vacuum, and all actions have consequences.

While Ghost in the Shell: Stand Alone Complex is laden down with weighty themes and conflicts, seasoned heavily over a multi-faceted thriller, does the series hold up as an anime, and as a consistently coherent story? Well, starting from a technical perspective, you won't hear me debating whether or not early 2000s 3DCG is always effective. Sure, it isn't Hand Shakers (2017) bad, and this was when 3D was really being ramped up throughout worldwide animation production for the first time. But in the first season, its limits ultimately inhibit immersion far more than it augments the series; and though the second season does improve significantly, the 2D and 3D content maintains a disjointed relationship. This is made even more prominent in scenes where settings are largely rendered in CG, because it takes away one of the key aspects which make the Japan in Ghost in the Shell feel so amazingtactility.

To make my point, let's go back to Oshii's 1995 feature film. As we follow the Major throughout Niihama, we are given a parade of locations which always play with two essential elements of this universeadvancement and decay. We see the mechanized limbs and bodies of cyberized humans meshing against a backdrop of a decrepit and overcrowded city. It is an amalgamation of cultures and historical eras conflicting with technological singularity, and the result is a sizable divide between haves and have-nots, which extends to the very buildings and streets we inhabit.

The lush color scheme of the original film gives an ethereal vibrancy to its world and characters, yet we also feel the weight. We get to see the rings of the tree, so to speak. In the colorized pages of the manga, you can also see its use of a fairly vivid and striking color palette. Both of these approaches were replaced in SAC with earthy colors, which can sometimes blend into a mess of murky hues. Gone are the overused waterways, the ever-constant infrastructure improvements, the ever-present blend of the chic and the decrepit. When we do get similar aesthetic combinations to these in SAC, we're usually venturing into more unsavory parts of town. As a result, this dichotomy becomes less reflective of the society as a whole, and more specifically tied to Japan's criminal elements and underclass, inadvertently reducing its overall effectiveness. Yes, adaptations are free to make of what they will with the material, especially when you have to make a lot of decisions as to where the limited resources are best directed, but when such an intrinsic element of the world is neglected, we lose a potent aspect which makes Ghost in the Shell so unique.

But opposite this, Stand Alone Complex 2nd GIG is a massive improvement, both in artistic direction, and in production design. It manages to recapture those original atmospheres while still keeping a lot of visual motifs established in the beginning, which I thoroughly enjoy and appreciate. Because buttressing your existing strengths, and changing those artistic decisions which fell flat, without sacrificing the integrity of your story or your visual identity to which your fans are already attracted, is extremely hard to do. Though it seems that Kamiyama may have forgotten to import his last save over to Ghost in the Shell: SAC_2045.

Having said that, Stand Alone Complex understands Shirow's sense of humor considerably better than Oshii. The manga's dark, yet playful sense of humor is one of the key features which were somewhat dismissed in the feature films, being the more serious take on the subject, to be sure. But Stand Alone Complex is constantly riffing, and most of the scenes featuring the Tachikomas find ways to throw in a fair few jokes even when the scene is deathly serious. And when we look at the Tachikomas in the manga, the snappy dialogue and pacing is almost an exact match. So while there were a few creative paths taken that I certainly have issues with, there also is enough beholden to what came before it, that Stand Alone Complex still manages to feel right despite the liberties taken.

Kamiyama manages to make expert use of his assets, making budget and production limitations almost negligible, and allowing the series to save the majority of its complex work for moments of higher octane action. There is little that I would describe as fluff or fat, with each sequence meticulously crafted around a succession of angles which always add further emphasis to each pivotal scene's tone and importance.

Similar anime series which share the same economical direction include Noboru Ishiguro's 1988 adaptation of Legend of the Galactic Heroes, Hideaki Anno's 1995 series Neon Genesis Evangelion, and Naohito Takahashi's 1997 anime adaptation of Berserk. Not much may be happening during these moments, but the lack of motion rarely makes me feel bored or impatient, because of what else is occurring and how it is delivered and paced. But on the flip side of that, these moments are often veritable shiploads of exposition, and if you aren't a fan of anime where they sit around and talk all day, this one probably won't be for you. Massive info dumps occur every couple of episodes, and there is little left to the imagination by the end of the series.

This conflicts with the natural ambiguity and uncertainty which hallmark the original work and the films, especially when The Major incorporates the Puppet Master into her cyberbrain, erasing the original Major (as the rest of Section 9 knew her) from existence. Now, as SAC is set on a different timeline, this never occurs, but it doesn't doesn't fill that void with an equitable conflict. That isn't to say you won't have a significant emotional response to the dour events which plague the Major and her colleagues, but the focus is considerably more drawn to the overarching story rather than personal introspection. Having said that, Stand Alone Complex benefits from its expanded runtime and scope, allowing episodes to focus on individual members of Section 9 in order to provide their stories to the audience, and to better understand their motivations, rather than keeping a microscope mostly fixed on Major Kusanagi. This creates a bit of a disparity between the tone of the manga and Oshii animated films, and that of Stand Alone Complex, the former two being considerably more ambiguous and emotional, where SAC is more cerebral and action-oriented. One isn't better than the other, as it comes down to a matter of preference. But I never had a reaction to Stand Alone Complex like I had with the manga or with the original films.

So, when I started making video essays for Anime News Network last year, my very first topic was on Serial Experiments Lain, in which I said the following: That isn't to say Lain's story is the pinnacle of cyberpunk, because Ghost in the Shell will always hold that spot in my world. While this was directed mostly at the manga and Oshii films, this declaration absolutely includes Stand Alone Complex. Its healthy balance of action, masterful direction, compelling intrigue, and the possibilities of technology. It makes for a prophetic thriller which may hit a little too close to home for some of you, and while the production elements can be hit-and-miss more times than some would allow, these same aspects can occasionally be outright brilliant.

While there's so much more I wanted to talk about, and stressed about it long enough that I had to delay putting this essay out for another month, I will end with saying that the second season surrounding the Individual Eleven, subtitled 2nd GIG, is far better at interweaving storylines and themes than the first, as well as providing minor characters with a lot more characterization and opportunities to influence the larger world. On the flip side, the first season is much more exploratory with its titular concept of a Stand Alone Complex, making for a more engaging thriller. Either way you cannot go wrong with the whole 52-episode series, because it continues to hold up extremely well, both as a stand alone project and as part of the greater Ghost in the Shell multimedia franchise. Ghost in the Shell: Stand Alone Complex remains one of those anime series that may not appeal to everyone, but everyone should give it at least one go. You get something new out of the series (and out of yourself) through each rewatch of the show, examining your own understanding and observations of how our world operates around us.

Thank you to everyone who've made it all the way to the end of this video essay. I know it couldn't have been easyyou're awesome. If you enjoyed (or have taken issue) with my interpretation and examination of Ghost in the Shell: Stand Alone Complex, leave a comment down below to let me know what you think. If you have an idea for an anime which you'd like me to cover, also let me know in the comments. If you haven't done so, subscribe to the Anime News Network. We release new content every week, so be sure to ring the bell. Be sure to mosey on over to my personal channel Criticlysm for similar content, and follow my utter misunderstanding of social media over on Twitter. I deeply appreciate your continued support and feedback. Until next time.

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Does it Hold Up? Ghost in the Shell: Stand Alone Complex - Anime News Network

Dubai Watch Week 2021 – Of Watches and Men (and Women!) – Dubai Watch Week – WorldTempus

For the Dubai Watch Weeks fifth edition since 2015, organisers have gone bigger and better. Around 50 exhibitors of all sizes are enjoying higher-quality, more comfortable surroundings, more breakout sessions and interactions with collectors and clients, sold-out watchmaking workshops, and journalists from every continent. The event is taking place from 24 to 28 November in the heart of Dubais financial district, the DIFC Gate Village, with its bustling art galleries and trendy restaurants. Although the event is entirely the initiative of the Seddiqi family, their name is nowhere to be seen. In their opening address, Hind and Mohammed Seddiqi explained their motivation: Were not here to sell, were here to educate and to promote watchmaking. Our goal is to create an unparalleled educational, experiential and networking event. But they also added: Go and have fun!

Dubai Watch Week shares its exhibition spaces between marquees, along with reception areas and a range of other activities, at the heart of the Gate Village in the Dubai International Financial Centre (DIFC) WorldTempus/Brice Lechevalier

Although the participating brands and their teams are there to present their products, no sales are allowed at the booths. Most exhibitors are using the platform to launch new products (local limited series or global releases), explain their particular features to potential future clients, and talk about their strategy. A measure of the importance of Dubai Watch Week is that most of the brand CEOs are in attendance, including the heads of Czapek, Trilobe, Audemars Piguet, Breitling, Chopard, Hublot and Rolex. Rolex CEO Jean-Frdric Dufour took the opportunity to greet the other executives at their own booths, noting, Its a very important event for the watchmaking community, because were opening our hearts here. From talking to the executives and artisans of the other exhibiting brands, its clear that everyone is delighted to meet an audience of genuine enthusiasts that really gives us great pleasure. Being able to talk one-on-one to a client who understands the technical know-how and expertise that go into making a watch, particularly a complicated watch, is very rewarding. The organisation is exemplary, and I would advise all Swiss watchmakers to come. Visitor numbers have been particularly high, especially in the evenings, when the wealthy residents of Dubai and watch collectors from the region, which is home to a number of collectors clubs, came to soak up the atmosphere. Networking is in full swing. Nigerian distributor Deremi Ajidahun (Zakaa) was full of praise for the dynamism of the event and the commitment of the organisers. Only Watch founder Luc Pettavino spoke at a collectors panel; and the CEO of Reuge, Amr Alotaishan, despite not having a booth, is more than just a regular visitor. He said: Although were not exhibiting this year were working with the Seddiqis, so its important for us to attend their event and observe whats going on in the watchmaking world, because Reuge is naturally part of their universe. GPHG director Carine Maillard and the chair of the GPHG Foundation, Raymond Lortan, answered journalists questions about the prize-winners exhibition:"We have been partners since the very beginning, and even before that. So DWW means a lot to the GPHG and even more this year since our Jury has decided to award its Special Jury Prize to this event, which is gaining momentum. We are delighted about that."

Audemars Piguet chose Dubai Watch Week to inaugurate its Beyond the Limits exhibition Audemars Piguet

Having travelled to Dubai with Rolex senior executives, CEO Jean-Frdric Dufour is seen here in the company of Dubai Watch Week organisers, Hind and Hamied Seddiqi WorldTempus/Brice Lechevalier

Browsing the booths revealed two trends among brands: those that are presenting limited series in partnership with Seddiqi or aimed at the local market, such as for the 50th anniversary of the founding of the United Arab Emirates, and those that take advantage of Dubai Watch Week as they would any other major international watch-themed event to introduce their new products. Certain of these releases are joint endeavours. Bvlgari and MB&F, for example, took the wraps off the Legacy Machine Flying T Allegra; the two partners had been working together on this new watch for the past four years. The launch was celebrated two nights running with a cocktail reception at the Cipriani pop-up, at the foot of the famous U-shaped tower. Despite the fact that virtually all the watches in the two 20-piece limited series have been pre-sold, MB&F founder Max Busser and Bvlgari creative director Fabrizio Buonamassa were generous with their interviews and presentations. This is the first collaboration between a very large, very strong brand and a small independent name like MB&F. We hit it off straight away. Fabrizio changed everything about our watch except the movement! In a different vein, Armin Strom took the wraps off the Zeitgeist, a single-piece edition to celebrate the fifth anniversary of the Resonance line. Co-founder Claude Geisler had this to say: We really appreciate once again having the opportunity to talk with the international press, but also with the other brands, thanks to the amicable and relaxed atmosphere that prevails here.

Fabrizio Buonamassa (Bulgari creative Director) and Maximilien Bsser (MB&F Founder and Creative Director) presenting their joint creation WorldTempus/Brice Lechevalier

MB&F x Bulgari LM FlyingT Allegra WorldTempus/Brice Lechevalier

Theres never any downtime at Dubai Watch Week. Brands are constantly on the go, and none more than the established independent niche brands. Edouard Meylan, CEO of H. Moser & Cie., is grateful towards Dubai Watch Week for having done so much to educate the end customer, ever since our first participation in 2015. Back then we were selling two watches a year in the region. No-one had heard of us. Now visitors are asking about availability for this or that product and buying in very significant numbers. Over at Urwerk, co-founder Felix Baumgartner notes that the market is surging. We could sell our entire production two or three times over! The positive aspect is that the most serious customers dont discuss prices so they can be sure to secure their watch, which suits retailers. For the founder of Akrivia, Rexhep Rexhepi, the market has grown. Were seeing customers coming out of nowhere who, all of a sudden, are taking an interest in our watches. And not just the super rich. Those with a normal level of wealth are forgoing a bigger car so they can buy themselves a watch. They appreciate the intrinsic value of a watch and what it stands for. The generosity of the Seddiqi family is also seen in the fact that brands they dont (yet?) carry are welcome to take part. Reservoir is one. Its CEO, Franois Moreau, says right from day one, we were highly satisfied with our participation. Weve met with local collectors as well as distributors from other countries in the region and journalists. The event is also extremely well organised. Its very Swiss in its approach. Even the big brands on a roll, like Hublot whose booth features a comfortable lounge area, consider Dubai Watch Week to be a must-attend, as CEO Ricardo Guadalupe confirms: Dubai Watch Week is hugely important for us. Not only is this a key market for Hublot our boutique in the Dubai Mall is also our number-one store in the world we particularly appreciate that we can meet with end customers during this pandemic, and have face-to-face talks with our local retailer, Seddiqi.

De Bethune came to Dubai Watch Week with its new DB25 QP with green dial that replaces all earlier references of the perpetual calendar WorldTempus/Brice Lechevalier

*Seddiqi & Sons is the largest retailer in the United Arab Emirates and the creator, in 2015, of Dubai Watch Week which since 2017 has been held every two years.

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Dubai Watch Week 2021 - Of Watches and Men (and Women!) - Dubai Watch Week - WorldTempus

The sci-fi thriller on Amazon Prime Video with a big twist at the end – CNET

Infinity Chamber (2016)

A character wakes up in a room with no windows, walls made of metal and no earthlyidea how he got there. He finds a sarcastic robot guard for company. When he attempts to break out of the prison cell, weird things happen -- and by the third scene, you'll probably experience deja vu from the day you watched Ex Machina or Moon.

2016's Infinity Chamber -- currently streaming onAmazon Prime-- essentially follows everyone's favorite "mysterious sci-fi movie" template. There's a foreboding backdrop, clear integration of humanity and technology and an intelligent protagonist who appears to be the voice of reason while grappling with a curious dilemma.

Regardless, its cerebral story immerses you deeply enough to root for the main character through the finish line while he plays a posthuman version of escape-the-room.

And if you make it to the climax, you're in for a treat.

Constructed with an impressively low budget of just $125,000,partially funded by Kickstarter, director Travis Milloy's perplexing film experiments with a complex plot that'll test your ability to predict endings -- and your patience.

While Frank Lerner (Christopher Soren Kelly) tries to leave his forsaken locked-up space, he's panged with lucid dreams of sitting in a quaint coffee shop and speaking to a charming barista named Gabby (Cassandra Clark).

Immediately after, Frank abruptly wakes up once again in his little chamber with only the company of Howard, an assigned machine companion who's reminiscent of 2001: A Space Odyssey's Hal, Interstellar's Tens and Moon's Gerty.

This sequence, which supposedly explains Frank's imprisonment, repeats itself again... and again... and again, giving Infinity Chamber its claustrophobic vibe. All the while, warm and genial robot Howard doesn't have much to say about any of this. Howard's only job is to keep Frank alive.

As the movie progresses, you start to realize what's really going on -- with Frank, Howard and even Gabby.

A self-proclaimed excellent twist-guesser, I was prepared to dismiss Infinity Chamber as a satisfactory retelling of the classic apocalyptic survival story. It's one of a slew of films that involve people puzzling their way out of a box-like room in a dystopian world. Some that fall into that niche genre include 1997's Cube, 2008's Fermat's Room, 2009's Exam and more recently, 2019's Escape Room.

But during the film's last 15 minutes or so, I let out a few involuntary "wait, whats" that were promptly followed by shock-fueled goosebumps. Infinity Chamber sets itself apart by taking overused tropes and adding flavor.

The chamber isn't just a room. Howard isn't merely a snarky AI and the dreams aren't random.

But while Infinity Chamber's ending is satisfying enough to deem the film a solid weeknight grab-a-glass-of-wine-and-chill choice, it's not without shortcomings. Those come from the film's half-baked sub-plots.

The movie introduces a love story, the notion of existing in your own dreams, the question of whether humans can truly bond with artificial intelligence and the ethics of prisons like the one Frank finds himself in.

Instead of delving into those concepts, however, a ton of time is spent rehashing Frank's pain of residing in the metal chamber and building up to the first milestone -- one that's so obvious, I was confused by how it was supposed to be a surprise at all.

Right around the halfway point, Infinity Chamber starts to get slightly boring shortly before picking up again for act three. Perhaps that could've been solved by exploring the film's other juicy sci-fi ideas -- there were so many interesting avenues left untaken.

Even so, from start to finish, Infinity Chamber is a delight. The shoestring budget and limited drawbacks are barely noticeable due to pristine production quality, terrific acting and a smart story chillingly tied together in its final scene -- one that makes the whole hour and 38 minutes 100% worth it.

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The sci-fi thriller on Amazon Prime Video with a big twist at the end - CNET

Big Tech Is Fighting Over Who Gets to Build a Cloud for the Pentagon – Tech.co

Big Tech companies Google, Amazon, and Microsoft as well as cloud infrastructure platform Oracle are going to battle it out for a multi-billion-dollar government contract and there's a chance they all might win.

The Department of Defense (DoD) said on Friday that it had issued formal solicitations to Microsoft which has just announced plans to build its own metaverse and three other companies regarding the Joint Warfighting Cloud Capability contract.

The news comes after years of legal battles, scrapped programs, and disagreements between tech companies desperate to get their names stamped on the lucrative government program.

In 2017, the Pentagon began to formulate plans for a Joint Enterprise Defense Infrastructure (JEDI) contract, with the goal to commission a company to build a centralized cloud infrastructure system that could be used to view, manage, and transfer confidential information safely across all security clearance levels, for all employees from the Pentagon to the edge of the battlefield.

The contract ended up being awarded to Microsoft not once, but twice, with the process marred by various lawsuits brought against the Department of Defense and the US government by companies like Amazon, who raised issues with how the contract was awarded.

In July, the Pentagon announced that it was scrapping the $10 billion, decade-long JEDI contract that had previously been awarded to Microsoft, on the grounds it was now obsolete due to long delays.

With the shifting technology environment, it has become clear that the Jedi Cloud contract, which has long been delayed, no longer meets the requirements to fill the DoD's capability gaps. US Department of Defense (DoD).

However, many believe it was then-president Donald Trumps animus towards Amazon CEO Jeff Bezos who owns the liberal-leaning paper The Washington Post that played a decisive role in Amazon initially missing out on JEDI and the subsequent decision to scrap it.

The decision left the door open for Microsoft and Amazon to bid for a new contract the JWCC along with other technology companies. However, only Amazon and Microsoft were initially contacted with pre-solicitation bids as they appeared to be the only two companies capable of delivering what the DoD need.

The JWCC is an IDIQ contract which means whoever is awarded it will have to provide an indefinite number of services over a specified time period.

The Pentagon has stiff criteria for what it expects to be developed, including tactical edge devices, pieces of technology used in battle scenarios or crisis environments that can function away from data centers and work for employees at all levels of government.

Whilst the JEDI contract took a winner-takes-all approach and Microsoft and Amazon are still very much favorites in the Pentagons eyes its a possibility that all of the companies in contention may end up with responsibility for at least some part of the project.

The Government anticipates awarding two IDIQ contracts one to Amazon Web Services, Inc. (AWS) and one to Microsoft Corporation (Microsoft) but intends to award to all Cloud Service Providers (CSPs) that demonstrate the capability to meet DoDs requirements. the US General Services Administration (GSA).

Google has, since July, instituted the security provisions needed to be in the running for a cloud service, but didnt previously bid for JEDI because it was thought the contract would conflict with its AI principles. IBM is also rumored to be interested in playing some part.

The disconnect between the wealthy executives populating Big Techs boardrooms and the staff that make their companies cogs turn has peppered the news over the past few years.

With workers rights and user safety already bones of contention that have been borne out in the public domain, the development of a war cloud may be the frontier upon which disagreement manifests.

Amazon Web Services, for instance, told CNBC that its commitment to supporting our nations military and ensuring that our warfighters and defense partners have access to the best technology for the best value is stronger than ever, illustrating that the company is staunchly in favor of working closely with the military.

And theres plenty of evidence that employees moral compasses tend to point in a different direction. Just recently, for instance, staff at Amazon as well as Google decried the involvement of their employers in Project Nimbus, a cloud service contract with the Israeli government that staff argue will be used to ramp up surveillance on Palestinian civilians.

What's more, dissent on these issues is often widespread the letter referenced above regarding Project Nimbus, which was published anonymously, claims to have over 300 Amazon and 90 Google employee signatures.

Google employees also protested the companys involvement in a drone program that utilized AI to improve accuracy, and a year later, Microsoft employees expressed their concern after their company was awarded a $480 million contract to develop augmented reality headsets for troops in combat zones.

It remains to be seen how the staff-exec relationships at these companies will fare under the strain of new, ethical quandaries like company involvement with military programs, but one thing's for sure: it'll take a lot more than an appeal to the better nature of Big Tech's profit-chasing chiefs to force them to turn down multi-billion-dollar contracts.

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Big Tech Is Fighting Over Who Gets to Build a Cloud for the Pentagon - Tech.co

Vestager urges European legislators to push through rules to regulate Big Tech – Financial Times

  1. Vestager urges European legislators to push through rules to regulate Big Tech  Financial Times
  2. Who will enforce Europes crackdown on Big Tech?  POLITICO.eu
  3. EU lawmakers agree on rules to target big tech- FT  Reuters
  4. Regulating 'big tech': Council agrees on enhancing competition in the digital sphere  EU News
  5. EU ministers back bloc's Big Tech clampdown  Tech Xplore
  6. View Full Coverage on Google News

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Vestager urges European legislators to push through rules to regulate Big Tech - Financial Times

Digital regulation must empower people to make the internet better – TechCrunch

Christian HumborgContributor

As COVID-19 spread rapidly across the world in 2020, people everywhere were hungry for reliable information. A global network of volunteers rose to the challenge, consolidating information from scientists, journalists and medical professionals, and making it accessible for everyday people.

Two of them live almost 3,200 kilometers away from one another: Dr. Alaa Najjar is a Wikipedia volunteer and medical doctor who spends breaks during his emergency room shift addressing COVID-19 misinformation on the Arabic version of the site. Sweden-based Dr. Netha Hussain, a clinical neuroscientist and doctor, spent her downtime editing COVID-19 articles in English and Malayalam (a language of southwestern India), later focusing her efforts on improving Wikipedia articles about COVID-19 vaccines.

Thanks to Najjar, Hussain and more than 280,000 volunteers, Wikipedia emerged as one of the most trusted sources for up-to-date, comprehensive knowledge about COVID-19, spanning nearly 7,000 articles in 188 languages. Wikipedias reach and ability to support knowledge-sharing on a global scale from informing the public about a major disease to helping students study for tests is only made possible by laws that enable its collaborative, volunteer-led model to thrive.

As the European Parliament considers new regulations aimed at holding Big Tech platforms accountable for illegal content amplified on their websites and apps through packages like the Digital Services Act (DSA), it must protect citizens ability to collaborate in service of the public interest.

Lawmakers are right to try to stem the spread of content that causes physical or psychological harm, including content that is illegal in many jurisdictions. As they consider a range of provisions for the comprehensive DSA, we welcome some of the proposed elements, including requirements for greater transparency about how platforms content moderation works.

But the current draft also includes prescriptive requirements for how terms of service should be enforced. At first glance, these measures may seem necessary to curb the rising power of social media, prevent the spread of illegal content and ensure the safety of online spaces. But what happens to projects like Wikipedia? Some of the proposed requirements could shift power further away from people to platform providers, stifling digital platforms that operate differently from the large commercial platforms.

Big Tech platforms work in fundamentally different ways than nonprofit, collaborative websites like Wikipedia. All of the articles created by Wikipedia volunteers are available for free, without ads and without tracking our readers browsing habits. The commercial platforms incentive structures maximize profits and time on site, using algorithms that leverage detailed user profiles to target people with content that is most likely to influence them. They deploy more algorithms to moderate content automatically, which results in errors of over- and under-enforcement. For example, computer programs often confuse artwork and satire with illegal content, while failing to understand human nuance and context necessary to enforce platforms actual rules.

The Wikimedia Foundation and affiliates based in specific countries, like Wikimedia Deutschland, support Wikipedia volunteers and their autonomy in making decisions about what information should exist on Wikipedia and what shouldnt. The online encyclopedias open editing model is grounded in the belief that people should decide what information stays on Wikipedia, leveraging established volunteer-developed rules for neutrality and reliable sources.

This model ensures that for any given Wikipedia article on any subject, people who know and care about a topic enforce the rules about what content is allowed on its page. Whats more, our content moderation is transparent and accountable: All conversations between editors on the platform are publicly accessible. It is not a perfect system, but it has largely worked to make Wikipedia a global source of neutral and verified information.

Forcing Wikipedia to operate more like a commercial platform with a top-down power structure, lacking accountability to our readers and editors, would arguably subvert the DSAs actual public interest intentions by leaving our communities out of important decisions about content.

The internet is at an inflection point. Democracy and civic space are under attack in Europe and around the world. Now, more than ever, all of us need to think carefully about how new rules will foster, not hinder, an online environment that allows for new forms of culture, science, participation and knowledge.

Lawmakers can engage with public interest communities such as ours to develop standards and principles that are more inclusive, more enforceable and more effective. But they should not impose rules that are aimed solely at the most powerful commercial internet platforms.

We all deserve a better, safer internet. We call on lawmakers to work with collaborators across sectors, including Wikimedia, to design regulations that empower citizens to improve it, together.

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Digital regulation must empower people to make the internet better - TechCrunch

The Metaverse, Crypto and EVs Are Among 2021s Big Tech Winners – Yahoo Finance

(Bloomberg) -- When Americans gather around the Thanksgiving table this week, the blistering rally in technology, electric vehicles and crypto-related stocks is likely to be a part of their conversations.

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Theres a reason it will dominate the small talk: The tech-heavy Nasdaq 100 is now worth almost half as much as the benchmark S&P 500 -- the highest ever -- and the megacap tech stocks alone represent a third of the S&P 500. Nvidia Corp. and Roblox Corp.s sprint stood out in a year when the rest of the big tech names jogged to new highs, defying several calls to sell the sector around last years thanksgiving due to soaring valuations.

Here some of the hottest stocks and themes since last Thanksgiving:

Hot Chips

Chipmaker Nvidia has soared 148% as booming chip demand and a foray into the metaverse made it the best performer on the Nasdaq 100. Applied Materials Inc. and Advanced Micro Devices Inc. were other winners, each rising about 80% and outperforming many of the megacap tech stocks.

Surging EV Makers

Tesla Inc. soared to a $1 trillion market value as the electric-carmakers shares doubled in value, driven by a sustained pickup in sales, even as part shortages were crippling the broader auto industry. EV fever was even more evident with Rivian Automotive Inc., which doubled in value in less than two weeks after going public. Lucid Group Inc. was the sectors other hot name.

Metaverse Mania

Robloxs tripling of value from its March listing to Facebooks name change to Meta Platforms Inc. showed the metaverse was the next big thing in tech. The rush to the space was evident with the Roundhill Ball Metaverse ETF, an exchange traded fund focused on the theme, surpassing $500 million in assets under management on Nov. 17, having doubled in just two weeks.

Story continues

Cryptocurrency Craze

From the digital world to digital money: Bitcoin briefly reclaiming $60,000 and a rally in smaller cryptocurrencies boosted a host of related stocks such as Marathon Digital Holdings Inc., Riot Blockchain Inc. and MicroStrategy Inc. Marathon Digital was among the top winners, with its stock jumping ten-fold.

Dont Forget FAANGs

Retail investors who stuck with big names havent done badly either. The likes of Microsoft Corp., Alphabet Inc. and Tesla Inc., have alone added a whopping $3.5 trillion in 2021, while the NYSE FANG+ Index is up about 39% since last Thanksgiving.

While those numbers are impressive, some say valuations do seem stretched. Tech stocks havent been this expensive since the Internet bubble of the late 1990s and many investors remain cautious.

Lets all be thankful for the tremendous returns weve seen in tech stocks and numerous other areas of the market this year, but not forget that a slice of humble pie may be what were eating next year if were too certain of our predictions to come, said Matt Carvalho, chief investment officer of Cardinal Point Wealth.

Tech Chart of the Day

Top Tech Stories

Indias Paytm plummeted for a second day after its IPO, marking one of the worst debuts ever by a major technology company

Prosus said analysts have valued its global portfolio of e-commerce assets at about $50 billion, excluding the stake in Tencent

JD.com Inc. and NetEase Inc.s tracking by MSCI via their Hong Kong shares rather than American Depositary Receipts might reinforce a gradual shift in liquidity away from the U.S. for Chinese stocks

Contemporary Amperex, a Tesla battery supplier, hit a fresh record to become Chinas second-largest company listed onshore

Activision Blizzards CEO said hed consider leaving if hes unable to quickly fix culture problems, Dow Jones reported

Ericsson is to buy Vonage Holdings for $5.3 billion as it strives to build market presence in cloud communications services

Most Read from Bloomberg Businessweek

2021 Bloomberg L.P.

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The Metaverse, Crypto and EVs Are Among 2021s Big Tech Winners - Yahoo Finance

The Irish DPC Slapped With Corruption Allegations; South Korea Place Big Tech Under the Microscope – ExchangeWire

In todays ExchangeWire news digest: The Irish DPC are slapped with a corruption complaint filed by noyb; Apple and Google could face fines of 2% under new Korea laws; and Niantic receive a hefty USD$300m (224.5m) investment from Coatue.

The Irish Data Protection Commission (DPC) has come under fire, having been accused of corruption and even bribery in a complaint filed by the non-profit organisation noyb. The organisation are alleging that the Irish commission have presented them with an ultimatum in the form of a letter: sign an illegal NDA within one working day or be removed from the Facebook procedure. noyb have declared this quid pro quo as procedural blackmail.

Vienna-based noyb filed the complaint to the Austrian Office for the Prosecution of Corruption. Subsequent to the filing, noyb published the letters they received, describing the request as unlawful: only if we shut up, the DPC would 'grant' us our legal right to be heard. The writing also shows the DPC demanding the not-for-profit to take down existing documents relating to the draft decision, once again without a legal basis.

It has been reported that Facebook (now Meta) would significantly benefit from a signed NDA, as new documents could compel EU regulators to find their GDPR bypass illegal. This would result in major implications for the tech giant if regulators were to declare their use of personal data since 2018 unlawful.

Max Schrems, chairperson of noyb.eu, comments, "the DPC acknowledges that it has a legal duty to hear us, but it now engaged in a form of 'procedural coercion'. The right to be heard was made conditional on us signing an agreement to the benefit of the DPC and Facebook. It is nothing but an authority demanding to give up the freedom of speech in exchange for procedural rights."

App store operators, such as Apple and Google, could face fines of up 2% of sales for forcing their own in-app payment methods, under the amended Telecommunications Business Act. The Korean Communications Commission (KCC) drafted the amendments on Wednesday (17 November), in order to protect app developers and provide further clarity when determining illegality of new prohibited acts. App store owners could also see an additional fine of 1% of their revenue for delays in reviewing apps.

Within the document, the KCC describe the forcing of certain payment methods as a serious illegal act which will result in penalty surcharges. The move has come to allow a fairer mobile ecosystem for developers, in an attempt to limit app store operators power within the industry. Obstructions against in-app billing policies were first introduced in August when South Korea made amendments to the Telecommunications Business Act. The challenge caught media attention when Epic filed a lawsuit against them for monopolistic behaviours back in 2020. South Korea were the first country to introduce restrictions on payment policies.

KCC Chairman Han Sang-hyuk commented, considering that this issue is receiving attention both at home and abroad, we will proceed swiftly with follow-up measures so that the law is enacted smoothly in order to create a fair and sound app market ecosystem.

Augmented reality (AR) platform, Niantic, have received a hefty investment of USD$300m (224.5m) from Coatue, valuing the company at USD$9bn (6.7bn). The software development company have announced that they will use the fund to build their vision for the real-world metaverse.

John Hanke, Niantics Founder and CEO, commented in a blog post announcing the news, were building a future where the real world is overlaid with digital creations, entertainment and information, making it more magical, fun and informative. He adds, this will take a significant investment of talent, technology and imagination, and were thrilled that Coatue is on this journey with us.

Niantic recently launched a platform enabling developers to understand and enhance their ideas for AR and the metaverse. The Lightship Platform is the core for the San Francisco-based companys own products, such as Pokmon GO.

In further metaverse-related news, Vietnamese startup VerseHub closes a silent fundraise of USD$1m (748,383) from an angel investor. The metaverse platform will use the funds, raised without going through the formal process, to enhance their ongoing projects. Co-founder and CTO of VerseHub, Canh Ho, explains, the team incubated the project 6 months ago and rejected many investment invitations, for cooperating with other Vietnamese partners in the industry, with the desire to contribute to the development of blockchain technology in our home country.

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The Irish DPC Slapped With Corruption Allegations; South Korea Place Big Tech Under the Microscope - ExchangeWire

Beijing issues fines for 43 Big Tech M&A deals all the way back to 2012 – The Register

China's State Administration for Market Regulation (SAMR) has fined tech giants 43 times with Alibaba, Baidu and Tencent told to pay up for failing to declare deals deemed to violate anti-monopoly legislation.

According to SAMR, more rigorous anti-monopoly law enforcement has seen businesses file more paperwork, sometimes about past transactions. SAMR's own probes have spotted acquisitions that weren't reported at the time.

Those efforts turned up 43 transactions, conducted between 2012 and 2021, that violated China's 2008 Anti-Monopoly Law. Each count received a fine of 500,000 ($78,300). The regulatory body said that all were "assessed as having no effect of excluding or restricting competition".

The market regulator posted about the fines on its WeChat account and Weibo page on Saturday.

State-sponsored media Global Times reported that Alibaba and Tencent each racked up more than ten cases.

SAMR explained that by penalising companies for past violations, it would "continuously optimize the fair, transparent and predictable competitive environment, and effectively urge enterprises to enhance their compliance awareness and ability to promote the sustained and healthy development of enterprises and industries".

China's national anti-monopoly bureau was inaugurated on Thursday and guidelines for antitrust compliance of enterprises abroad were issued the same day.

The government in Beijing, and SAMR in particular, has been busy. Earlier this month the organization drafted new rules for internet platforms considered "super large" that hold them to higher standards than smaller, less influential ones in an attempt to stamp out anticompetitive behavior.

In September, the org ordered Alibaba, Tencent and more to stop blocking links to rivals. And it has been known to step in and outright ban mergers it deems imprudent.

Those new initiatives follow many others that appear to give China the power to rein in its big tech companies often in ways that would prevent them from acquiring the kind of power that Western tech companies accumulated. Perhaps ironically, the USA is currently considering legislative restrictions on new acquisitions by its tech giants, on grounds that they use such transactions to curtail competition early. By fining its own tech giants for transactions nearly a decade in the past, China appears to be applying similar logic.

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Beijing issues fines for 43 Big Tech M&A deals all the way back to 2012 - The Register

Tide turns against big tech but it’s going to be a long, long haul – Crikey

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Dismantling or reassembling the tech giants' hold on the way we live now will be a truly massive undertaking.

The genius of Mark Zuckerberg's recent announcement of Meta, the alleged new Facebook, was that it managed to be both disappointing and sinister at the same time. Backed by a series of lame effects, the Zuck announced a virtual world that sounded as gimmicky and unsatisfying as Second Life had been, but authored by an organisation which had the power to enforce it everywhere.

The utterly uninspiring vision of Meta, like all such tech, draws on the utopian impulses which lurk in culture, in art, and in the very structure of human imagining and projection: that we can project worlds that are radically other to everyday life and yet are still recognisable and meaningful and able to be controlled and commodified.

The disappointment that has been widely expressed at this concept is due to what might be called the accumulated insufficiency of dreams.

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Guy Rundle is correspondent-at-large for Crikey. He's a former editor of Arena Magazine and contributes to a variety of publications in Australia and the United Kingdom.

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Tide turns against big tech but it's going to be a long, long haul - Crikey

Inside the ‘big wave’ of misinformation targeted at Latinos – Associated Press

WASHINGTON (AP) Before last years presidential election, Facebook ads targeting Latino voters described Joe Biden as a communist. During his inauguration, another conspiracy theory spread online and on Spanish-language radio warning that a brooch worn by Lady Gaga signaled Biden was working with shadowy, leftist figures abroad.

And in the final stretch of Virginias election for governor, stories written in Spanish accused Biden of ordering the arrest of a man during a school board meeting.

None of that was true. But such misinformation represents a growing threat to Democrats, who are anxious about their standing with Latino voters after surprise losses last year in places like South Florida and the Rio Grande Valley in Texas.

Heading into a midterm election in which control of Congress is at stake, lawmakers, researchers and activists are preparing for another onslaught of falsehoods targeted at Spanish-speaking voters. And they say social media platforms that often host those mistruths arent prepared.

For a lot of people, theres a lot of concern that 2022 will be another big wave, said Guy Mentel, executive director of Global Americans, a think tank that provides analysis of key issues throughout the Americas.

This months elections may be a preview of whats to come.

After Democratic incumbent Phil Murphy won New Jerseys close governors race, Spanish-language videos falsely claimed the vote was rigged, despite no evidence of widespread voter fraud a fact the Republican candidate acknowledged, calling the results legal and fair.

In Virginia, where Republican Glenn Youngkin campaigned successfully on promises to defend parental rights in classrooms, false headlines around a controversial school board meeting emerged.

Biden orden arrestar a padre de una joven violada por un trans, read one of several misleading articles, translating to Biden ordered the arrest of a father whose daughter was raped by a trans.

The mistruth was spun from an altercation during a chaotic school board meeting months earlier in Loudoun County that resulted in the arrest of a father whose daughter was sexually assaulted in a bathroom by another student. The father claimed the suspect was gender fluid, which sparked outcry over the schools policy allowing transgender students to use bathrooms matching their gender identity.

In reality, the White House wasnt involved with the meeting. The man was arrested by the local sheriffs department. Its also unclear how the suspect identifies.

Loudoun County was already the epicenter of a heated political debate over how the history of racism is taught in schools another issue that became fodder for misinformation and political attacks on Spanish-language websites this summer, said Maria Teresa Kumar, president and CEO of Voto Latino, a nonprofit that mobilizes Hispanics to become politically engaged.

It has everything to do with trust in institutions. Trust in government, said Kumar, whose group works to combat the misinformation. Eroding that trust will transfer not just to voting in the midterms, but just overall disengagement from your government.

Stretched truths accusing some Democrats of being socialists or communists could also dominate the online narrative, said Diego Groisman, a research analyst at New York Universitys Cybersecurity for Democracy project.

During the 2020 election, Groisman flagged Facebook ads targeting Latino voters in Texas and Florida that described Biden as a communist. The ads in Florida where a majority of the countrys Venezuelan population is concentrated compared Biden to that countrys socialist President Nicols Maduro.

There were clearly specific Spanish-speaking communities that were being targeted, said Laura Edelson, the lead researcher for NYUs program.

Evelyn Prez-Verda, a Florida Democratic strategist who watches Spanish misinformation patterns, says many online narratives intentionally stoke fear in the Spanish-speaking communities.

One conspiracy theory mentioned on talk radio grew out of Lady Gagas golden bird brooch at Bidens inauguration. Some spreading the claim noted a similar brooch once worn by Claudia Lpez Hernandez, the first openly gay mayor of Bogota, Colombia, signaled the new president was working with foreign leftists.

Theyre not going to stop. Theyre going to double down on it, Prez-Verda said of the misinformation.

Critics argue that social media companies like Meta, which owns Facebook, Instagram and WhatsApp, have placed outsize attention on removing or fact-checking misinformation in English over other languages like Spanish.

Facebooks own documents, leaked by ex-Facebook employee turned whistleblower Frances Haugen earlier this year, echo those concerns. Haugen said the company spends 87% of its misinformation budget on U.S. content a figure that Meta spokesperson Kevin McAllister said is out of context.

An internal Facebook memo, written in March, revealed the companys ability to detect anti-vaccine rhetoric and misinformation was basically non-existent in non-English comments.

Last year, for example, Instagram and Facebook banned #plandemic, a hashtag associated with a video full of COVID-19 conspiracy theories. Yet users were spreading misinformation on the platforms using #plandemia, the Spanish version of the hashtag, until just last month.

An analysis last year by Avaaz, a left-leaning advocacy group that tracks online misinformation, also found Facebook failed to flag 70% of Spanish-language misinformation surrounding COVID-19 compared to just 29% of such information in English.

McAllister said the company removes false Spanish-language claims about voter fraud, COVID-19 and vaccines. Four news outlets, including The Associated Press, also fact-check Spanish-language falsehoods circulating around U.S. content on Instagram and Facebook.

Meanwhile, researchers at the nonpartisan Global Disinformation Index estimated that Google will make $12 million this year off ads on websites that peddled COVID-19 disinformation in Spanish. Google has stopped serving ads on a majority of the pages shared in the report, company spokesperson Michael Aciman said in an email.

Spanish-language misinformation campaigns are absolutely exploding on social media platforms like Facebook, WhatsApp, etc., New York Democratic Rep. Alexandria Ocasio-Cortez, one of the partys top progressive voices, tweeted after the Nov. 2 election.

That explosion is fueled in part by a U.S.-Latin America feedback loop that allows falsehoods to fester.

Misinformation that starts on U.S. websites is sometimes translated by social media pages in Latin American countries like Colombia and Venezuela. The inaccuracies are shared back through YouTube videos or messaging apps with Spanish speakers in expatriate communities like those in Miami and Houston.

Those falsehoods are more likely to reach U.S. Latinos because they tend to spend more time on sites such as YouTube, WhatsApp, Instagram and Telegram, according to an October Nielsen report.

We see YouTube accounts or radio stations churning out mis- or disinformation regarding a whole range of things that they pick up from fringe U.S. outlets, Mentel said.

Some are working to fill the void of reliable information in those communities.

The Oakland, California, news service El Timpano delivers a text message of local news in Spanish to roughly 2,000 subscribers every week. Subscribers can text back with questions that staffers work to answer, said Madeleine Blair, who launched El Timpano.

The news service has fielded more than 1,500 questions over the past year, including ones about hoax COVID-19 cures.

We really ramped up because it was clear that the communities we were serving were most in need of basic public health information, Blair said, and that information wasnt reaching them.

Others have urged the government to take on a watchdog role. Federal Trade Commission commissioner Rebecca Kelly Slaughter, a Democrat, said the regulator may look at disparities in how Big Tech monitors English-language disinformation compared to other languages.

The first thing I think we need to do is investigate, Slaughter said during a November panel with lawmakers.

___

Associated Press writers Marcos Martnez Chacn in Monterrey, Mexico, Abril Mulato in Mexico City and Marcy Gordon in Washington contributed to this report.

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Inside the 'big wave' of misinformation targeted at Latinos - Associated Press

‘More money than God:’ Chinese titan lavished Hunter Biden with 3-carat gem, offer of $30 million – New York Post

The Biden family offered their services to a huge, Chinese-government-linked energy consortium to expand its business around the world. How do we know? Because of hundreds of emails documenting the deal found on Hunter Bidens laptop, left in a Delaware repair shop in April 2019. In her new book, Laptop from Hell, New York Post columnist Miranda Devine tells the tale:

James Gilliar, a wiry, 56-year-old British ex-SAS officer, got to know Ye Jianming, the 40-year-old chairman of CEFC, when they were both working in the Czech Republic.

CEFC was a Chinese conglomerate, one of the largest energy companies in the world.

Yes task at was to spend $1.5 billion as quickly as possible to ensure the Czech Republic would become Chinas Gateway to the European Union, a priority of President Xi.

To that end, Ye bought everything from a football team and a brewery to an airline, before being named special economic advisor to Czech President Milos Zeman.

Now he was looking for an influential partner to help with acquisitions in other locations around the world that had strategic significance for the Chinese state.

Gilliar had an idea who could help: The Biden family.

Gilliar connected with Hunter Biden through trusted Biden family friend Rob Walker, a former Clinton administration official whose wife, Betsy Massey Walker, had been Jill Bidens assistant when she was Second Lady.

Gilliar emailed Walker in February 2015 to praise Hunters appearance in Beijing at a board meeting of the fledgling investment fund Hunter had founded with John Kerrys son, called BHR.

Hunter was great, Gilliar wrote to Walker. True sheikh of Washington.

He emailed Hunter a few weeks later: It has been made clear to me that CEFC wish to engage in further business relations with our group.

Gilliar knew CEFC was the capitalist arm of President Xis Belt and Road Initiative to spread Chinas influence and debt traps across the world. No Chinese company executed its goals more ardently than CEFC and its young chairman, who was dubbed the Belt and Road billionaire in the press.

Chairman Ye had built his provincial energy company into a Fortune 500 colossus virtually overnight, an achievement described by Chinese news agency Caixin as another great enigma in the miraculous world of Chinese business. He enjoyed the support of President Xi and was former deputy secretary general of the governments propaganda arm, the China Association for International Friendly Contacts.

In a rare interview with Caixin at CEFCs palatial marble headquarters in Shanghais upscale French Concession District, Ye is portrayed as a hermit king sitting on a golden chair in a room that resembles a miniature Great Hall of the People.

Uniformed staff members wearing earpieces glide by. Most of them were young women wearing smart clothes and bright faces.

Yes face was as expressionless as a stone statue. Amidst the gilded surroundings, his canvas shoes had an eye-catching plainness. . . .

In his public activities as a private entrepreneur, Ye Jianming is al- ways walking alongside important foreign political figures. He has been photographed with world leaders such as Israeli President Peres, Turkish President Erdogan, Chadian President Dby, and European Commission President Juncker. He has met with the Crown Prince of Abu Dhabi, and the Prime Minister of Bulgaria held a feast to welcome him.

In the winter of 2015, Chairman Ye and CEFC Executive Director Jianjun Zang, a.k.a. Director Zang, flew to Washington, DC. A meeting with Ye was scheduled in Hunters diary for December 7, 2015, in a week that was a swirl of back-to-back Christmas parties hosted by Joe and Jill at the vice presidents residence at the Naval Observatory.

One of his former associates, who spoke on condition of anonymity, believes that Hunter brought Chairman Ye to meet Joe at one of those parties. There is no indication of any such meeting on the laptop, but Hunter had a pattern of introducing business associates to Joe when they came to DC.

After a frustrating experience in another Chinese deal as a minority partner in private equity firm BHR, in which the payday would not come until the end of the funds life, Hunter and his uncle Jim Biden wanted more control of the CEFC partnership and a regular income stream.

Enter Tony Bobulinski. The naval officer turned wealthy institutional investor came highly recommended by Gilliar to build what they planned would be a world-class investment firm, called SinoHawk, named after Hunters late brother Beaus favorite animal, the hawk.

In December 2015, Gilliar tells Bobulinski he needs help structuring a Chinese joint venture for one of the most prominent families in the United States.

The plan is to build an investment firm like Goldman Sachs, he writes in a WhatsApp message, transcripts of which were obtained separate from the laptop.

The family is the Biden family, Gilliar will soon disclose. Joe, who has announced that he will not run for president in 2016, will be actively involved once he leaves office, and the Bidens expect billions of dollars of projects to flow through the company, Gilliar says.

He lets Bobulinski in on the last piece of the puzzle in March 2016: the Bidens Chinese partner is CEFC, which has more money than God, he writes. This is the capital arm of one belt one road.

At about this time, Bobulinski is introduced to Rob Walker, who tells him he is a proxy for Hunter Biden, Jim Biden and the Bidens around the world.

Finally, in February 2017, Gilliar sends Bobulinski a WhatsApp message saying he wants to introduce him to his partner.

Who is your partner? asks Bobulinski.

Hunter Biden, replies Gilliar.

Bobulinski is leery. I understand you want me to . . . help drive things in the US, but Hunter is [already] here.

Gilliar: Money there, intent there . . . skill sets missing . . . We need to create the best deal platform in history, and they havent got a clue. Bobulinski doesnt like the fact Hunter was kicked out of US Navy for cocaine use.

But hes super smart, says Gilliar. Just a lot of under achievers around them using their name. Has a few demons but u are used to those, right?

Bobulinski asks: Is he the decision maker or the Chinese?

Gilliar: New platform. Best discuss face to face but Im the driver.

Later, Bobulinski asks: Ok who is putting up the $10MM [million]?

Gilliar: Joint vehicle half us and then equally split money is already in. Discuss more face to face.

Three weeks after his father left office, in 2017, Hunter flew to Miami with Gilliar and Walker to meet Chairman Ye, who was there for the Miami International Boat Show.

They booked into the $700 a night beachfront Nobu Hotel on Monday, Feb. 13, 2017, and scheduled lunch with the Chinese for Thursday in a private room set for 10 at the Bourbon Steak restaurant in the ritzy JW Marriott Turnberry Resort & Spa, where Ye was staying with his entourage.

But Hunter flew home the day before the lunch. He already had met with Ye, over a private dinner on the Tuesday night, at which the CEFC chairman made him an offer too good to refuse: $10 million a year, for a minimum of three years, for introductions alone, as Hunter would later assert in an imperious email to CEFC executives.

Ye sealed the new alliance with a rich gift a 3.16 carat diamond worth $80,000. Photographs of the stunning stone appear on Hunters laptop along with a grading report that lists it as a round brilliant of Grade F with prime VS2 clarity and excellent cut.

The gift could not have come at a better time. Hunter was in the middle of an ugly divorce from Kathleen, and his office manager, Joan Peugh, had just sent him the latest in a series of overdue bills, a tax collection notice from the District of Columbia for $47,226.78.

Hunter would tell the New Yorkers Adam Entous that he had flown to Miami to meet Chairman Ye purely for charitable purposes, hoping to secure a donation to World Food Program USA, the nonprofit on whose board he served and which he had used before as a cover for his foreign business activities.

Hunter said it was just chance that the altruistic encounter turned to business opportunities and claimed to be surprised when Ye gave him the diamond. He didnt mention the happy coincidence that his business partners Gilliar and Walker were with him in Miami to clinch a business deal with CEFC.

But the diamond was just an appetizer.

Nine days after Hunters meeting in Miami with Ye, $3 million is wired into an account for Rob Walkers company, Robinson Walker LLC, from State Energy HK Limited, a Shanghai-based company linked to CEFC, according to the Chuck Grassley-Ron Johnson inquiry.

On March 1, another $3 million is wired to Robinson Walker by the same company. Both transactions are flagged by the Department of Treasurys Financial Crimes Enforcement network in a suspicious activity report, filed with the Senate committees as Confidential Document 16.

Using the document as a source, the Grassley-Johnson report of Nov. 18, 2020, says: At the time of the transfers, State Energy HK Limited was affiliated with CEFC China Energy, which was under the leadership of Ye Jianming. In the past, State Energy HK Limited transferred funds to at least one company associated with Hunter Bidens business associate, Gongwen Dong . . .

These transactions are a direct link between Walker and the communist Chinese government and, because of his close association with Hunter Biden, yet another tie between Hunter Bidens financial arrange- ments and the communist Chinese government.

The Senate report concludes it is unclear what the true purpose is behind these transactions [$6 million from CEFC] and who the ultimate beneficiary is.

We know from the laptop that Hunter received regular payments from Robinson Walker. One document lists $56,603.74 from Robinson Walker as income for Rosemont Seneca Advisors, between June and December 2017.

Rob Walker paid at least $511,000 to Hunters firm Owasco in 2017, according to an email from Hunters tax accountant, Bill Morgan.

Walker tells Bobulinski his role in CEFC is being a surrogate for H [Hunter] or Jim when gauging opportunities, i.e. digging around in Texas on high speed rail with some of my republican friends . . . or hitting new countries and contacts abroad where things are lukewarm, but not hot enough for H to close or too odd for H to be present . . .

On March 5, 2017, Page Six breaks the news that Hunter and his brothers widow Hallie are an item.

When Hunter doesnt show up for a scheduled meeting three days later in New York, Gilliar tells Bobulinski it doesnt matter: In brand hes imperative but right now hes not essential for adding input to business.

It is at this point that Gilliar explains to Bobulinski that the Chinese involved in CEFC are intelligence so they understand the value added of the Biden name.

Bobulinski remains troubled by Hunters scandals, and Gilliar, who is in Australia with Director Zang looking for acquisitions, is worried he might pull out. So, he arranges for him to meet Hunter the following month at the Chateau Marmont, in Bobulinskis hometown of L.A.

They meet by the hotel pool in April and speak for two hours while Hunter chain-smokes. Bobulinski finds him respectful and polite. Hunter boasts that he has his fathers ear and can bypass his advisers.

Hunter tells Bobulinski how the joint venture vehicle should be structured and expresses caution about US laws, including the Foreign Corrupt Practices Act (FCPA), which prohibits businesses paying bribes to foreign officials. He appears to conflate that law with the Foreign Agents Registration Act (FARA), a 1938 antispying law that requires anyone acting as a lobbyist for a foreign power to register with the US government as a foreign agent.

No matter what, it will need to be a US company at some level in order for us to make bids on federal and state funded projects, Hunter writes later.

Also, we dont want to have to register as foreign agents under the FCPA which is much more expansive than people who should know choose not to know.

Regardless we should have a . . . company called CEFC America, and ownership should be 50 me 50 them. We then cut up our 50 [percent] in a separate entity between the 4 of us.

Hunter seems focused, but Bobulinski is puzzled about Uncle Jims frequent meddling in CEFC business.

For instance, in April 2017, Jim pulls strings at New Yorks elite Horace Mann School to get Director Zangs daughter Rouqi fast-tracked for entry, although she ends up enrolling in another school.

Jim also writes a letter on behalf of CEFC to New York Gov. Andrew Cuomo requesting a meeting. We intend to discuss potential projects and investments in New York. He lists the other attendees as Hunter, Chairman Ye, Director Zang, and an unnamed Member of the Royal Family of Luxembourg.

What is the deal w Jim Biden as he wasnt part of the discussion but now seems a focal point? Bobulinski asks Gilliar. What role does Jim see himself playing?

Consultant is what hes offered as [far as] I know, Gilliar replies. He [Hunter] brought in Jim simply to leverage getting more equity for himself and family in the final hour, that is evident.

In another WhatsApp message, Gilliar tells Bobulinski: With H [Hunters] demons, could be good to have a backup, he [Jim] strengthens our USP [unique selling point] to Chinese as it looks like a truly family business, and I like the dude.

With the deal progressing, Hunter tells Bobulinski its time for the next step.

I want Dad to meet you, he says.

Excerpted with permission from Laptop from Hell: Hunter Biden, Big Tech, and the Dirty Secrets the President Tried to Hide (Post Hill Press), out Tuesday.

To order Miranda Devines new book, click here.

Link:

'More money than God:' Chinese titan lavished Hunter Biden with 3-carat gem, offer of $30 million - New York Post

UK antitrust chief relies on EU in global drive to regulate big tech – City A.M.

Friday 26 November 2021 2:32 pm

The head of Britains antitrust watchdog said he plans to pick his battles with tech companies carefully relying on EU counterparts to take the lead where necessary.

Andrea Coscelli, chief executive officer of the UKs Competition and Markets Authority, told Bloomberg he might let other agencies lead the way on tech regulation because some merger probes are better suited to certain courts and jurisdictions than others.

You cannot expect when there is a problem, every single agency to go after it, because we all have to make choices, Coscelli said.

Theres quite a lot of good stuff on tech thats happening in Brussels that will have a direct positive benefit for UK consumers, he added, noting that the EUs case on Amazons marketplace should have wider benefits despite the CMA not pursuing a similar case.

It comes after the EUs General Court fined Google 2bn in an anti-trust case hours after the UKs supreme court voted down a privacy case which would have seen 4.4m Brits receive payouts totalling 3bn.

Europes campaign to regulate big tech is spearheaded by MargretheVestager, the EUs competition policy lead, with the Commissions efforts casting a shadow over Britains approach to regulation. Vestager is in the process of taking on Amazon Marketplace over concerns the site gives its own products preferential treatment over other retailers.

Meanwhile, the UKs CMA today announced plans to go after Google over proposals to remove third party cookies from peoples browsers. The competition authority wants to ensure that Google does not restrict external companies from accessing user data in a way that harms competition in digital advertising markets.

In pursuit of a more joined up approach to tech regulation Coscelli will next week meet with the worlds top antitrust enforcers in London in order to discuss digital markets regulation. G-7 regulators are expected to discuss a cross-border framework for enforcing competition rules.

Read more: EU agree common position to curb US tech giants

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UK antitrust chief relies on EU in global drive to regulate big tech - City A.M.

DBS Bank strategits sees Big Tech as big beneficiaries of the Metaverse – CoinJournal

We have seen several cryptocurrencies linked to the increasingly interesting Metaverse space make huge gains in recent weeks. Projects such as The Sandbox (SAND), Decentraland (MANA), and Enjin Coin (ENJ) have witnessed an upside driven by investor interest in the concept of a Metaverse.

Crypto and blockchain projects could be among those to benefit massively from the idea, but according to DBS senior investment strategist Daryl Ho, investors could do well to look at two key sectors likely to play a big role as the initiative takes shape.

In aninterview with CNBCs Squawk Box, Ho said that companies and platforms that are already deep in the digitisation space could have the front seat when it comes to defining the Metaverse and thus benefitting the most.

If you dont already realize it, we are already moving somewhat towards a digital world, so the Metaverse is simply the next step, the next frontier, Ho explained.

Recently, Meta Platforms (formerly Facebook), took a giant step in announcing plans for developing the Metaverse, and major companies around the world are looking to follow suit as the reality of a virtual world grows.

Its with this perspective that the investment strategist says two particular sectors could take the lead and be highly profitable to investors.

He believes the computer gaming industry has the upper hand here, given the sector is already immersed in the virtual world. Notably, it's in the Metaverse would see people live, work and collaborate and gaming platforms have represented this in many ways in their gaming projects.

I think these are the companies [investors] should look out for, he said, adding that the sector is likely to be the one that shape[s] the metaverse as we know it.

Ho also believes that big technology companies have all it takes to maintain a leading role in the Metaverse and will be big beneficiaries.

Apart from Meta, other Big Tech companies towatch out for are Google, Apple, Microsoft and game company Valve.

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DBS Bank strategits sees Big Tech as big beneficiaries of the Metaverse - CoinJournal

COVID-19 – Wikipedia

Coronavirus disease 2019 (COVID-19) is a contagious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The first known case was identified in Wuhan, China, in December 2019.[7] The disease has since spread worldwide, leading to an ongoing pandemic.[8]

Symptoms of COVID-19 are variable, but often include fever,[9] cough, headache,[10] fatigue, breathing difficulties, and loss of smell and taste.[11][12][13] Symptoms may begin one to fourteen days after exposure to the virus. At least a third of people who are infected do not develop noticeable symptoms.[14] Of those people who develop symptoms noticeable enough to be classed as patients, most (81%) develop mild to moderate symptoms (up to mild pneumonia), while 14% develop severe symptoms (dyspnea, hypoxia, or more than 50% lung involvement on imaging), and 5% suffer critical symptoms (respiratory failure, shock, or multiorgan dysfunction).[15] Older people are at a higher risk of developing severe symptoms. Some people continue to experience a range of effects (long COVID) for months after recovery, and damage to organs has been observed.[16] Multi-year studies are underway to further investigate the long-term effects of the disease.[16]

COVID-19 transmits when people breathe in air contaminated by droplets and small airborne particles containing the virus. The risk of breathing these in is highest when people are in close proximity, but they can be inhaled over longer distances, particularly indoors. Transmission can also occur if splashed or sprayed with contaminated fluids in the eyes, nose or mouth, and, rarely, via contaminated surfaces. People remain contagious for up to 20 days, and can spread the virus even if they do not develop symptoms.[17][18]

Several testing methods have been developed to diagnose the disease. The standard diagnostic method is by detection of the virus' nucleic acid by real-time reverse transcription polymerase chain reaction (rRT-PCR), transcription-mediated amplification (TMA), or by reverse transcription loop-mediated isothermal amplification (RT-LAMP) from a nasopharyngeal swab.

Several COVID-19 vaccines have been approved and distributed in various countries, which have initiated mass vaccination campaigns. Other preventive measures include physical or social distancing, quarantining, ventilation of indoor spaces, covering coughs and sneezes, hand washing, and keeping unwashed hands away from the face. The use of face masks or coverings has been recommended in public settings to minimize the risk of transmissions. While work is underway to develop drugs that inhibit the virus, the primary treatment is symptomatic. Management involves the treatment of symptoms, supportive care, isolation, and experimental measures.

During the initial outbreak in Wuhan, the virus and disease were commonly referred to as "coronavirus" and "Wuhan coronavirus",[19][20][21] with the disease sometimes called "Wuhan pneumonia".[22][23] In the past, many diseases have been named after geographical locations, such as the Spanish flu,[24] Middle East respiratory syndrome, and Zika virus.[25] In January 2020, the WHO recommended 2019-nCoV[26] and 2019-nCoV acute respiratory disease[27] as interim names for the virus and disease per 2015 guidance and international guidelines against using geographical locations (e.g. Wuhan, China), animal species, or groups of people in disease and virus names in part to prevent social stigma.[28][29][30] The official names COVID-19 and SARS-CoV-2 were issued by the WHO on 11 February 2020.[31] Tedros Adhanom explained: COfor corona, VIfor virus, Dfor disease, and 19 for 2019 (the year in which the outbreak was first identified).[32] The WHO additionally uses "the COVID-19 virus" and "the virus responsible for COVID-19" in public communications.[31]

Symptoms of COVID-19 are variable, ranging from mild symptoms to severe illness.[33][34] Common symptoms include headache, loss of smell and taste, nasal congestion and runny nose, cough, muscle pain, sore throat, fever, diarrhea, and breathing difficulties.[35] People with the same infection may have different symptoms, and their symptoms may change over time. Three common clusters of symptoms have been identified: one respiratory symptom cluster with cough, sputum, shortness of breath, and fever; a musculoskeletal symptom cluster with muscle and joint pain, headache, and fatigue; a cluster of digestive symptoms with abdominal pain, vomiting, and diarrhea.[35] In people without prior ear, nose, and throat disorders, loss of taste combined with loss of smell is associated with COVID-19 and is reported in as many as 88% of cases.[36][37][38]

Of people who show symptoms, 81% develop only mild to moderate symptoms (up to mild pneumonia), while 14% develop severe symptoms (dyspnea, hypoxia, or more than 50% lung involvement on imaging) and 5% of patients suffer critical symptoms (respiratory failure, shock, or multiorgan dysfunction).[39] At least a third of the people who are infected with the virus do not develop noticeable symptoms at any point in time.[40][41] These asymptomatic carriers tend not to get tested and can spread the disease.[41][42][43][44] Other infected people will develop symptoms later, called "pre-symptomatic", or have very mild symptoms and can also spread the virus.[44]

As is common with infections, there is a delay between the moment a person first becomes infected and the appearance of the first symptoms. The median delay for COVID-19 is four to five days.[45] Most symptomatic people experience symptoms within two to seven days after exposure, and almost all will experience at least one symptom within 12 days.[45][46]

COVID-19 is caused by infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus strain.[50]

The respiratory route of spread of COVID-19, encompassing larger droplets and aerosols.

The disease is mainly transmitted via the respiratory route when people inhale droplets and small airborne particles (that form an aerosol) that infected people exhale as they breathe, talk, cough, sneeze, or sing.[51][52][53][54] Infected people are more likely to transmit COVID-19 when they are physically close. However, infection can occur over longer distances, particularly indoors.[51][55]

Infectivity can occur 1-3 days before the onset of symptoms.[56] Infected persons can spread the disease even if they are pre-symptomatic or asymptomatic.[56] Most commonly, the peak viral load in upper respiratory tract samples occurs close to the time of symptom onset and declines after the first week after symptoms begin.[56] Current evidence suggests a duration of viral shedding and the period of infectiousness of up to 10 days following symptom onset for persons with mild to moderate COVID-19, and a up to 20 days for persons with severe COVID-19, including immunocompromised persons.[57][56]

Infectious particles range in size from aerosols that remain suspended in the air for long periods of time to larger droplets that remain airborne or fall to the ground.[58][59][60][61] Additionally, COVID-19 research has redefined the traditional understanding of how respiratory viruses are transmitted.[61][62] The largest droplets of respiratory fluid do not travel far, and can be inhaled or land on mucous membranes on the eyes, nose, or mouth to infect.[60] Aerosols are highest in concentration when people are in close proximity, which leads to easier viral transmission when people are physically close,[60][61][62] but airborne transmission can occur at longer distances, mainly in locations that are poorly ventilated;[60] in those conditions small particles can remain suspended in the air for minutes to hours.[60]

Severe acute respiratory syndrome coronavirus2 (SARS-CoV-2) is a novel severe acute respiratory syndrome coronavirus. It was first isolated from three people with pneumonia connected to the cluster of acute respiratory illness cases in Wuhan.[66] All structural features of the novel SARS-CoV-2 virus particle occur in related coronaviruses in nature.[67]

Outside the human body, the virus is destroyed by household soap, which bursts its protective bubble.[68]

SARS-CoV-2 is closely related to the original SARS-CoV.[69] It is thought to have an animal (zoonotic) origin. Genetic analysis has revealed that the coronavirus genetically clusters with the genus Betacoronavirus, in subgenus Sarbecovirus (lineage B) together with two bat-derived strains. It is 96% identical at the whole genome level to other bat coronavirus samples (BatCov RaTG13).[70][71] The structural proteins of SARS-CoV-2 include membrane glycoprotein (M), envelope protein (E), nucleocapsid protein (N), and the spike protein (S). The M protein of SARS-CoV-2 is about 98% similar to the M protein of bat SARS-CoV, maintains around 98% homology with pangolin SARS-CoV, and has 90% homology with the M protein of SARS-CoV; whereas, the similarity is only around 38% with the M protein of MERS-CoV. The structure of the M protein resembles the sugar transporter SemiSWEET.[72]

The many thousands of SARS-CoV-2 variants are grouped into either clades or lineages.[73][74] The WHO, in collaboration with partners, expert networks, national authorities, institutions and researchers, have established nomenclature systems for naming and tracking SARS-CoV-2 genetic lineages by GISAID, Nextstrain and Pango. At the present time, the expert group convened by WHO has recommended the labeling of variants using letters of the Greek Alphabet, for example, Alpha, Beta, Delta, and Gamma, giving the justification that they "will be easier and more practical to discussed by non-scientific audiences."[75] Nextstrain divides the variants into five clades (19A, 19B, 20A, 20B, and 20C), while GISAID divides them into seven (L, O, V, S, G, GH, and GR).[76] The Pango tool groups variants into lineages, with many circulating lineages being classed under the B.1 lineage.[74][77]

Several notable variants of SARS-CoV-2 emerged throughout 2020.[78][79] Cluster 5 emerged among minks and mink farmers in Denmark.[80] After strict quarantines and a mink euthanasia campaign, the cluster was assessed to no longer be circulating among humans in Denmark as of 1 February 2021.[81]

As of July 2021[update], there are four dominant variants of SARS-CoV-2 spreading among global populations: the Alpha Variant (formerly called the UK Variant and officially referred to as B.1.1.7), first found in London and Kent, the Beta Variant (formerly called the South Africa Variant and officially referred to as B.1.351), the Gamma Variant (formerly called the Brazil Variant and officially referred to as P.1), and the Delta Variant (formerly called the India Variant and officially referred to as B.1.617.2).[82]

Using whole genome sequencing, epidemiology and modelling suggest the Alpha variant VUI-202012/01 (the first variant under investigation in December 2020) in the B.1.1.7 lineage transmits more easily than some other strains.[83][needs update]

The SARS-CoV-2 virus can infect a wide range of cells and systems of the body. COVID-19 is most known for affecting the upper respiratory tract (sinuses, nose, and throat) and the lower respiratory tract (windpipe and lungs).[84] The lungs are the organs most affected by COVID-19 because the virus accesses host cells via the receptor for the enzyme angiotensin-converting enzyme 2 (ACE2), which is most abundant on the surface of type II alveolar cells of the lungs.[85] The virus uses a special surface glycoprotein called a "spike" to connect to the ACE2 receptor and enter the host cell.[86]

Following viral entry, COVID-19 infects the ciliated epithelium of the nasopharynx and upper airways.[87]

One common symptom, loss of smell, results from infection of the support cells of the olfactory epithelium, with subsequent damage to the olfactory neurons.[88] The involvement of both the central and prepheral nervous system in COVID-19 has been reported in many medical publications.[89] It is clear that many people with COVID-19 exhibit neurological or mental health issues. The virus is not detected in the CNS of the majority of COVID-19 patients with neurological issues. However, SARS-CoV-2 has been detected at low levels in the brains of those who have died from COVID-19, but these results need to be confirmed.[90] While virus has been detected in cerebrospinal fluid of autopsies, the exact mechanism by which it invades the CNS remains unclear and may first involve invasion of peripheral nerves given the low levels of ACE2 in the brain.[91][92][93] The virus may also enter the bloodstream from the lungs and cross the blood-brain barrier to gain access to the CNS, possibly within an infected white blood cell.[90]

The virus also affects gastrointestinal organs as ACE2 is abundantly expressed in the glandular cells of gastric, duodenal and rectal epithelium[94] as well as endothelial cells and enterocytes of the small intestine.[95]

The virus can cause acute myocardial injury and chronic damage to the cardiovascular system.[96] An acute cardiac injury was found in 12% of infected people admitted to the hospital in Wuhan, China,[97] and is more frequent in severe disease.[98] Rates of cardiovascular symptoms are high, owing to the systemic inflammatory response and immune system disorders during disease progression, but acute myocardial injuries may also be related to ACE2 receptors in the heart.[96] ACE2 receptors are highly expressed in the heart and are involved in heart function.[96][99] A high incidence of thrombosis and venous thromboembolism have been found in people transferred to Intensive care units (ICU) with COVID-19 infections, and may be related to poor prognosis.[100] Blood vessel dysfunction and clot formation (as suggested by high D-dimer levels caused by blood clots) are thought to play a significant role in mortality, incidences of clots leading to pulmonary embolisms, and ischaemic events within the brain have been noted as complications leading to death in people infected with SARS-CoV-2. Infection appears to set off a chain of vasoconstrictive responses within the body, constriction of blood vessels within the pulmonary circulation has also been posited as a mechanism in which oxygenation decreases alongside the presentation of viral pneumonia.[101] Furthermore, microvascular (arterioles and capillaries) blood vessel damage has been reported in a small number of tissue samples of the brains without detected SARS-CoV-2 and the olfactory bulbs from those who have died from COVID-19.[102][103][104] COVID-19 was also found to cause substantial including morphological and mechanical changes to blood cells such as increased sizes sometimes persisting for months after hospital discharge.[105][106]

Another common cause of death is complications related to the kidneys.[101] Early reports show that up to 30% of hospitalized patients both in China and in New York have experienced some injury to their kidneys, including some persons with no previous kidney problems.[107]

Autopsies of people who died of COVID-19 have found diffuse alveolar damage, and lymphocyte-containing inflammatory infiltrates within the lung.[108]

Although SARS-CoV-2 has a tropism for ACE2-expressing epithelial cells of the respiratory tract, people with severe COVID-19 have symptoms of systemic hyperinflammation. Clinical laboratory findings of elevated IL2, IL7, IL6, granulocyte-macrophage colony-stimulating factor (GMCSF), interferon gamma-induced protein10 (IP10), monocyte chemoattractant protein1 (MCP1), macrophage inflammatory protein 1alpha (MIP1alpha), and tumour necrosis factor (TNF) indicative of cytokine release syndrome (CRS) suggest an underlying immunopathology.[97]

Additionally, people with COVID-19 and acute respiratory distress syndrome (ARDS) have classical serum biomarkers of CRS, including elevated C-reactive protein (CRP), lactate dehydrogenase (LDH), D-dimer, and ferritin.[109]

Systemic inflammation results in vasodilation, allowing inflammatory lymphocytic and monocytic infiltration of the lung and the heart. In particular, pathogenic GM-CSF-secreting Tcells were shown to correlate with the recruitment of inflammatory IL-6-secreting monocytes and severe lung pathology in people with COVID-19.[110] Lymphocytic infiltrates have also been reported at autopsy.[108]

Multiple viral and host factors affect the pathogenesis of the virus. The S-protein, otherwise known as the spike protein, is the viral component that attaches to the host receptor via the ACE2 receptors. It includes two subunits: S1 and S2. S1 determines the virus-host range and cellular tropism via the receptor-binding domain. S2 mediates the membrane fusion of the virus to its potential cell host via the H1 and HR2, which are heptad repeat regions. Studies have shown that S1 domain induced IgG and IgA antibody levels at a much higher capacity. It is the focus spike proteins expression that are involved in many effective COVID-19 vaccines.[111]

The M protein is the viral protein responsible for the transmembrane transport of nutrients. It is the cause of the bud release and the formation of the viral envelope.[112] The N and E protein are accessory proteins that interfere with the host's immune response.[112]

Human angiotensin converting enzyme 2 (hACE2) is the host factor that SARS-COV2 virus targets causing COVID-19. Theoretically, the usage of angiotensin receptor blockers (ARB) and ACE inhibitors upregulating ACE2 expression might increase morbidity with COVID-19, though animal data suggest some potential protective effect of ARB; however no clinical studies have proven susceptibility or outcomes. Until further data is available, guidelines and recommendations for hypertensive patients remain.[113]

The effect of the virus on ACE2 cell surfaces leads to leukocytic infiltration, increased blood vessel permeability, alveolar wall permeability, as well as decreased secretion of lung surfactants. These effects cause the majority of the respiratory symptoms. However, the aggravation of local inflammation causes a cytokine storm eventually leading to a systemic inflammatory response syndrome.[114]

Among healthy adults not exposed to SARS-CoV-2, about 35% have CD4+ T cells that recognize the SARS-CoV-2 S protein (particularly the S2 subunit) and about 50% react to other proteins of the virus, suggesting cross-reactivity from previous common colds caused by other coronaviruses.[115]

It is unknown whether different persons use similar antibody genes in response to COVID-19.[116]

The severity of the inflammation can be attributed to the severity of what is known as the cytokine storm.[117] Levels of interleukin1B, interferon-gamma, interferon-inducible protein 10, and monocyte chemoattractant protein1 were all associated with COVID-19 disease severity. Treatment has been proposed to combat the cytokine storm as it remains to be one of the leading causes of morbidity and mortality in COVID-19 disease.[118]

A cytokine storm is due to an acute hyperinflammatory response that is responsible for clinical illness in an array of diseases but in COVID-19, it is related to worse prognosis and increased fatality. The storm causes acute respiratory distress syndrome, blood clotting events such as strokes, myocardial infarction, encephalitis, acute kidney injury, and vasculitis. The production of IL-1, IL-2, IL-6, TNF-alpha, and interferon-gamma, all crucial components of normal immune responses, inadvertently become the causes of a cytokine storm. The cells of the central nervous system, the microglia, neurons, and astrocytes, are also involved in the release of pro-inflammatory cytokines affecting the nervous system, and effects of cytokine storms toward the CNS are not uncommon.[119]

There are many unknowns for pregnant women during the COVID-19 pandemic. Given that they are prone to suffering from complications and severe disease infection with other types of coronaviruses, they have been identified as a vulnerable group and advised to take supplementary preventive measures.[120]

Physiological responses to pregnancy can include:

However, from the evidence base, it is difficult to conclude whether pregnant women are at increased risk of grave consequences of this virus.[120]

In addition to the above, other clinical studies have proved that SARS-CoV-2 can affect the period of pregnancy in different ways. On the one hand, there is little evidence of its impact up to 12 weeks gestation. On the other hand, COVID-19 infection may cause increased rates of unfavorable outcomes in the course of the pregnancy. Some examples of these could be fetal growth restriction, preterm birth, and perinatal mortality, which refers to the fetal death past 22 or 28 completed weeks of pregnancy as well as the death among live-born children up to seven completed days of life.[120]

Unvaccinated women in later stages of pregnancy with COVID-19 are more likely than other patients to need very intensive care. Babies born to mothers with COVID-19 are more likely to have breathing problems. Pregnant women are strongly encouraged to get vaccinated.[121]

COVID-19 can provisionally be diagnosed on the basis of symptoms and confirmed using reverse transcription polymerase chain reaction (RT-PCR) or other nucleic acid testing of infected secretions.[122][123] Along with laboratory testing, chest CT scans may be helpful to diagnose COVID-19 in individuals with a high clinical suspicion of infection.[124] Detection of a past infection is possible with serological tests, which detect antibodies produced by the body in response to the infection.[122]

The standard methods of testing for presence of SARS-CoV-2 are nucleic acid tests,[122][125] which detects the presence of viral RNA fragments.[126] As these tests detect RNA but not infectious virus, its "ability to determine duration of infectivity of patients is limited."[127] The test is typically done on respiratory samples obtained by a nasopharyngeal swab; however, a nasal swab or sputum sample may also be used.[128][129] Results are generally available within hours.[122] The WHO has published several testing protocols for the disease.[130]

Several laboratories and companies have developed serological tests, which detect antibodies produced by the body in response to infection. Several have been evaluated by Public Health England and approved for use in the UK.[131]

The University of Oxford's CEBM has pointed to mounting evidence[132][133] that "a good proportion of 'new' mild cases and people re-testing positives after quarantine or discharge from hospital are not infectious, but are simply clearing harmless virus particles which their immune system has efficiently dealt with" and have called for "an international effort to standardize and periodically calibrate testing"[134] On 7September, the UK government issued "guidance for procedures to be implemented in laboratories to provide assurance of positive SARS-CoV-2 RNA results during periods of low prevalence, when there is a reduction in the predictive value of positive test results".[135]

Chest CT scans may be helpful to diagnose COVID-19 in individuals with a high clinical suspicion of infection but are not recommended for routine screening.[124][136] Bilateral multilobar ground-glass opacities with a peripheral, asymmetric, and posterior distribution are common in early infection.[124][137] Subpleural dominance, crazy paving (lobular septal thickening with variable alveolar filling), and consolidation may appear as the disease progresses.[124][138] Characteristic imaging features on chest radiographs and computed tomography (CT) of people who are symptomatic include asymmetric peripheral ground-glass opacities without pleural effusions.[139]

Many groups have created COVID-19 datasets that include imagery such as the Italian Radiological Society which has compiled an international online database of imaging findings for confirmed cases.[140] Due to overlap with other infections such as adenovirus, imaging without confirmation by rRT-PCR is of limited specificity in identifying COVID-19.[139] A large study in China compared chest CT results to PCR and demonstrated that though imaging is less specific for the infection, it is faster and more sensitive.[123]

In late 2019, the WHO assigned emergency ICD-10 disease codes U07.1 for deaths from lab-confirmed SARS-CoV-2 infection and U07.2 for deaths from clinically or epidemiologically diagnosed COVID-19 without lab-confirmed SARS-CoV-2 infection.[141]

The main pathological findings at autopsy are:

Preventive measures to reduce the chances of infection include getting vaccinated, staying at home, wearing a mask in public, avoiding crowded places, keeping distance from others, ventilating indoor spaces, managing potential exposure durations,[147] washing hands with soap and water often and for at least twenty seconds, practising good respiratory hygiene, and avoiding touching the eyes, nose, or mouth with unwashed hands.[148][149]

Those diagnosed with COVID-19 or who believe they may be infected are advised by the CDC to stay home except to get medical care, call ahead before visiting a healthcare provider, wear a face mask before entering the healthcare provider's office and when in any room or vehicle with another person, cover coughs and sneezes with a tissue, regularly wash hands with soap and water and avoid sharing personal household items.[150][151]

The first COVID-19 vaccine was granted regulatory approval on 2December by the UK medicines regulator MHRA.[152] It was evaluated for emergency use authorization (EUA) status by the US FDA, and in several other countries.[153] Initially, the US National Institutes of Health guidelines do not recommend any medication for prevention of COVID-19, before or after exposure to the SARS-CoV-2 virus, outside the setting of a clinical trial.[154][155] Without a vaccine, other prophylactic measures, or effective treatments, a key part of managing COVID-19 is trying to decrease and delay the epidemic peak, known as "flattening the curve".[156] This is done by slowing the infection rate to decrease the risk of health services being overwhelmed, allowing for better treatment of active cases, and delaying additional cases until effective treatments or a vaccine become available.[156][157]

A COVID19 vaccine is a vaccine intended to provide acquired immunity against severe acute respiratory syndrome coronavirus 2 (SARSCoV2), the virus that causes coronavirus disease 2019 (COVID19). Prior to the COVID19 pandemic, an established body of knowledge existed about the structure and function of coronaviruses causing diseases like severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). This knowledge accelerated the development of various vaccine platforms during early 2020.[158] The initial focus of SARS-CoV-2 vaccines was on preventing symptomatic, often severe illness.[159] On 10 January 2020, the SARS-CoV-2 genetic sequence data was shared through GISAID, and by 19 March, the global pharmaceutical industry announced a major commitment to address COVID19.[160] The COVID19 vaccines are widely credited for their role in reducing the severity and death caused by COVID19.[161]

Many countries have implemented phased distribution plans that prioritize those at highest risk of complications, such as the elderly, and those at high risk of exposure and transmission, such as healthcare workers.[162]

The WHO and the US CDC recommend individuals wear non-medical face coverings in public settings where there is an increased risk of transmission and where social distancing measures are difficult to maintain.[166][167] This recommendation is meant to reduce the spread of the disease by asymptomatic and pre-symptomatic individuals and is complementary to established preventive measures such as social distancing.[167][168] Face coverings limit the volume and travel distance of expiratory droplets dispersed when talking, breathing, and coughing.[167][168] A face covering without vents or holes will also filter out particles containing the virus from inhaled and exhaled air, reducing the chances of infection.[169] But, if the mask include an exhalation valve, a wearer that is infected (maybe without having noticed that, and asymptomatic) would transmit the virus outwards through it, despite any certification they can have. So the masks with exhalation valve are not for the infected wearers, and are not reliable to stop the pandemic in a large scale. Many countries and local jurisdictions encourage or mandate the use of face masks or cloth face coverings by members of the public to limit the spread of the virus.[170]

Masks are also strongly recommended for those who may have been infected and those taking care of someone who may have the disease.[171] When not wearing a mask, the CDC recommends covering the mouth and nose with a tissue when coughing or sneezing and recommends using the inside of the elbow if no tissue is available. Proper hand hygiene after any cough or sneeze is encouraged. Healthcare professionals interacting directly with people who have COVID-19 are advised to use respirators at least as protective as NIOSH-certified N95 or equivalent, in addition to other personal protective equipment.[172]

The CDC recommends that crowded indoor spaces should be avoided.[173] When indoors, increasing the rate of air change, decreasing recirculation of air and increasing the use of outdoor air can reduce transmission.[173][174] The WHO recommends ventilation and air filtration in public spaces to help clear out infectious aerosols.[175][176][177]

Exhaled respiratory particles can build-up within enclosed spaces with inadequate ventilation. The risk of COVID-19 infection increases especially in spaces where people engage in physical exertion or raise their voice (e.g., exercising, shouting, singing) as this increases exhalation of respiratory droplets. Prolonged exposure to these conditions, typically more than 15 minutes, leads to higher risk of infection.[173]

Displacement ventilation with large natural inlets can move stale air directly to the exhaust in laminar flow while significantly reducing the concentration of droplets and particles. Passive ventilation reduces energy consumption and maintenance costs but may lack controllability and heat recovery. Displacement ventilation can also be achieved mechanically with higher energy and maintenance costs. The use of large ducts and openings helps to prevent mixing in closed environments. Recirculation and mixing should be avoided because recirculation prevents dilution of harmful particles and redistributes possibly contaminated air, and mixing increases the concentration and range of infectious particles and keeps larger particles in the air.[178]

Thorough hand hygiene after any cough or sneeze is required.[179] The WHO also recommends that individuals wash hands often with soap and water for at least twenty seconds, especially after going to the toilet or when hands are visibly dirty, before eating and after blowing one's nose.[180] When soap and water are not available, the CDC recommends using an alcohol-based hand sanitiser with at least 60% alcohol.[181] For areas where commercial hand sanitisers are not readily available, the WHO provides two formulations for local production. In these formulations, the antimicrobial activity arises from ethanol or isopropanol. Hydrogen peroxide is used to help eliminate bacterial spores in the alcohol; it is "not an active substance for hand antisepsis." Glycerol is added as a humectant.[182]

Social distancing (also known as physical distancing) includes infection control actions intended to slow the spread of the disease by minimising close contact between individuals. Methods include quarantines; travel restrictions; and the closing of schools, workplaces, stadiums, theatres, or shopping centres. Individuals may apply social distancing methods by staying at home, limiting travel, avoiding crowded areas, using no-contact greetings, and physically distancing themselves from others.[4] Many governments are now mandating or recommending social distancing in regions affected by the outbreak.[183]

Outbreaks have occurred in prisons due to crowding and an inability to enforce adequate social distancing.[184][185] In the United States, the prisoner population is aging and many of them are at high risk for poor outcomes from COVID-19 due to high rates of coexisting heart and lung disease, and poor access to high-quality healthcare.[184]

After being expelled from the body, coronaviruses can survive on surfaces for hours to days. If a person touches the dirty surface, they may deposit the virus at the eyes, nose, or mouth where it can enter the body and cause infection.[186] Evidence indicates that contact with infected surfaces is not the main driver of COVID-19,[187][188][189] leading to recommendations for optimised disinfection procedures to avoid issues such as the increase of antimicrobial resistance through the use of inappropriate cleaning products and processes.[190][191] Deep cleaning and other surface sanitation has been criticized as hygiene theater, giving a false sense of security against something primarily spread through the air.[192][193]

The amount of time that the virus can survive depends significantly on the type of surface, the temperature, and the humidity.[194] Coronaviruses die very quickly when exposed to the UV light in sunlight.[194] Like other enveloped viruses, SARS-CoV-2 survives longest when the temperature is at room temperature or lower, and when the relative humidity is low (<50%).[194]

On many surfaces, including glass, some types of plastic, stainless steel, and skin, the virus can remain infective for several days indoors at room temperature, or even about a week under ideal conditions.[194][195] On some surfaces, including cotton fabric and copper, the virus usually dies after a few hours.[194] The virus dies faster on porous surfaces than on non-porous surfaces due to capillary action within pores and faster aerosol droplet evaporation.[196][189][194] However, of the many surfaces tested, two with the longest survival times are N95 respirator masks and surgical masks, both of which are considered porous surfaces.[194]

The CDC says that in most situations, cleaning surfaces with soap or detergent, not disinfecting, is enough to reduce risk of transmission.[197][198] The CDC recommends that if a COVID-19 case is suspected or confirmed at a facility such as an office or day care, all areas such as offices, bathrooms, common areas, shared electronic equipment like tablets, touch screens, keyboards, remote controls, and ATM machines used by the ill persons should be disinfected.[199] Surfaces may be decontaminated with 6271 percent ethanol, 50100 percent isopropanol, 0.1 percent sodium hypochlorite, 0.5 percent hydrogen peroxide, and 0.27.5 percent povidone-iodine. Other solutions, such as benzalkonium chloride and chlorhexidine gluconate, are less effective. Ultraviolet germicidal irradiation may also be used.[175] A datasheet comprising the authorised substances to disinfection in the food industry (including suspension or surface tested, kind of surface, use dilution, disinfectant and inocuylum volumes) can be seen in the supplementary material of.[190]

Self-isolation at home has been recommended for those diagnosed with COVID-19 and those who suspect they have been infected. Health agencies have issued detailed instructions for proper self-isolation.[200] Many governments have mandated or recommended self-quarantine for entire populations. The strongest self-quarantine instructions have been issued to those in high-risk groups.[201] Those who may have been exposed to someone with COVID-19 and those who have recently travelled to a country or region with the widespread transmission have been advised to self-quarantine for 14 days from the time of last possible exposure.[202]

The Harvard T.H. Chan School of Public Health recommends a healthy diet, being physically active, managing psychological stress, and getting enough sleep.[203]

Consistently meeting scientific guidelines of 150+ minutes per week of exercise or similar physical activity was shown to be associated with a smaller risk of hospitalisation and death due to COVID-19, even when considering likely risk factors such as elevated BMI.[204][205]

A meta-analysis, published online in October 2021, concluded that Vitamin D supplementation in SARS-CoV-2 positive patients has the potential to positively impact patients with both mild and severe symptoms.[206] The largest clinical trial on the subject, with over 6 000 participants and a dosage regime near the RDI, is set to conclude in July 2021.[207][208]

A 2021 Cochrane rapid review found that based upon low-certainty evidence, international travel-related control measures such as restricting cross-border travel may help to contain the spread of COVID-19.[209] Additionally, symptom/exposure-based screening measures at borders may miss many positive cases.[209] While test-based border screening measures may be more effective, it could also miss many positive cases if only conducted upon arrival without follow-up. The review concluded that a minimum 10-day quarantine may be beneficial in preventing the spread of COVID-19 and may be more effective if combined with an additional control measure like border screening.[209]

There is no specific, effective treatment or cure for coronavirus disease 2019 (COVID-19), the disease caused by the SARS-CoV-2 virus.[210][needs update][211] One year into the pandemic, highly effective vaccines have now been introduced and are beginning to slow the spread of SARS-CoV-2; however, for those awaiting vaccination, as well as for the estimated millions of immunocompromised persons who are unlikely to respond robustly to vaccination, treatment remains important.[212] Thus, the lack of progress developing effective treatments means that the cornerstone of management of COVID-19 has been supportive care, which includes treatment to relieve symptoms, fluid therapy, oxygen support and prone positioning as needed, and medications or devices to support other affected vital organs.[213][214][215]

Most cases of COVID-19 are mild. In these, supportive care includes medication such as paracetamol or NSAIDs to relieve symptoms (fever, body aches, cough), proper intake of fluids, rest, and nasal breathing.[216][211][217][218] Good personal hygiene and a healthy diet are also recommended.[219] The U.S. Centers for Disease Control and Prevention (CDC) recommend that those who suspect they are carrying the virus isolate themselves at home and wear a face mask.[220]

People with more severe cases may need treatment in hospital. In those with low oxygen levels, use of the glucocorticoid dexamethasone is strongly recommended, as it can reduce the risk of death.[221][222][223] Noninvasive ventilation and, ultimately, admission to an intensive care unit for mechanical ventilation may be required to support breathing.[224] Extracorporeal membrane oxygenation (ECMO) has been used to address the issue of respiratory failure, but its benefits are still under consideration.[225][226] Some of the cases of severe disease course are caused by systemic hyper-inflammation, the so called cytokine storm.[227]

The severity of COVID-19 varies. The disease may take a mild course with few or no symptoms, resembling other common upper respiratory diseases such as the common cold. In 34% of cases (7.4% for those over age 65) symptoms are severe enough to cause hospitalization.[235] Mild cases typically recover within two weeks, while those with severe or critical diseases may take three to six weeks to recover. Among those who have died, the time from symptom onset to death has ranged from two to eight weeks.[70] The Italian Istituto Superiore di Sanit reported that the median time between the onset of symptoms and death was twelve days, with seven being hospitalised. However, people transferred to an ICU had a median time of ten days between hospitalisation and death.[236] Prolonged prothrombin time and elevated C-reactive protein levels on admission to the hospital are associated with severe course of COVID-19 and with a transfer to ICU.[237][238]

Some early studies suggest 10% to 20% of people with COVID-19 will experience symptoms lasting longer than a month.[239][240] A majority of those who were admitted to hospital with severe disease report long-term problems including fatigue and shortness of breath.[241] On 30 October 2020, WHO chief Tedros Adhanom warned that "to a significant number of people, the COVID virus poses a range of serious long-term effects." He has described the vast spectrum of COVID-19 symptoms that fluctuate over time as "really concerning". They range from fatigue, a cough and shortness of breath, to inflammation and injury of major organs including the lungs and heart, and also neurological and psychologic effects. Symptoms often overlap and can affect any system in the body. Infected people have reported cyclical bouts of fatigue, headaches, months of complete exhaustion, mood swings, and other symptoms. Tedros therefore concluded that a strategy of achieving herd immunity by infection, rather than vaccination, is "morally unconscionable and unfeasible".[242]

In terms of hospital readmissions about 9% of 106,000 individuals had to return for hospital treatment within two months of discharge. The average to readmit was eight days since first hospital visit. There are several risk factors that have been identified as being a cause of multiple admissions to a hospital facility. Among these are advanced age (above 65 years of age) and presence of a chronic condition such as diabetes, COPD, heart failure or chronic kidney disease.[243][244]

According to scientific reviews smokers are more likely to require intensive care or die compared to non-smokers.[245][246] Acting on the same ACE2 pulmonary receptors affected by smoking, air pollution has been correlated with the disease.[246] Short term[247] and chronic[248] exposure to air pollution seems to enhance morbidity and mortality from COVID-19.[249][250][251] Pre-existing heart and lung diseases[252] and also obesity, especially in conjunction with fatty liver disease, contributes to an increased health risk of COVID-19.[246][253][254][255]

It is also assumed that those that are immunocompromised are at higher risk of getting severely sick from SARS-CoV-2.[256] One research that looked into the COVID-19 infections in hospitalized kidney transplant recipients found a mortality rate of 11%.[257]

Genetics also plays an important role in the ability to fight off the disease.[258] For instance, those that do not produce detectable type I interferons or produce auto-antibodies against these may get much sicker from COVID-19.[259][260] Genetic screening is able to detect interferon effector genes.[261]

Pregnant women may be at higher risk of severe COVID-19 infection based on data from other similar viruses, like SARS and MERS, but data for COVID-19 is lacking.

While very young children have experienced lower rates of infection, older children have a rate of infection that is similar to the population as a whole.[262][263] Children are likely to have milder symptoms and are at lower risk of severe disease than adults.[264] The CDC reports that in the US roughly a third of hospitalized children were admitted to the ICU,[265] while a European multinational study of hospitalized children from June 2020 found that about 8% of children admitted to a hospital needed intensive care.[266] Four of the 582 children (0.7%) in the European study died, but the actual mortality rate may be "substantially lower" since milder cases that did not seek medical help were not included in the study.[267][268]

Complications may include pneumonia, acute respiratory distress syndrome (ARDS), multi-organ failure, septic shock, and death.[269][270][271][272] Cardiovascular complications may include heart failure, arrhythmias (including atrial fibrillation), heart inflammation, and thrombosis, particularly venous thromboembolism.[273][274][275][276][277][278] Approximately 2030% of people who present with COVID-19 have elevated liver enzymes, reflecting liver injury.[279][155]

Neurologic manifestations include seizure, stroke, encephalitis, and GuillainBarr syndrome (which includes loss of motor functions).[280][281] Following the infection, children may develop paediatric multisystem inflammatory syndrome, which has symptoms similar to Kawasaki disease, which can be fatal.[282][283] In very rare cases, acute encephalopathy can occur, and it can be considered in those who have been diagnosed with COVID-19 and have an altered mental status.[284]

In the case of pregnant women, it is important to note that, according to the Centers for Disease Control and Prevention, pregnant women are at increased risk of becoming seriously ill from COVID-19.[285] This is because pregnant women with COVID-19 appear to be more likely to develop respiratory and obstetric complications that can lead to miscarriage, premature delivery and intrauterine growth restriction.[285]

Fungal infections such as aspergillosis, candidiasis, cryptococcosis and mucormycosis have been recorded in patients recovering from COVID-19.[286][287]

Some early studies suggest that 10-20% of people with COVID-19 will experience symptoms lasting longer than a month.[288][240] A majority of those who were admitted to hospital with severe disease report long-term problems, including fatigue and shortness of breath.[289] About 510% of patients admitted to hospital progress to severe or critical disease, including pneumonia and acute respiratory failure.[290]

By a variety of mechanisms, the lungs are the organs most affected in COVID-19.[291] In people requiring hospital admission, up to 98% of CT scans performed show lung abnormalities after 28 days of illness even if they had clinically improved.[292]

People with advanced age, severe disease, prolonged ICU stays, or who smoke are more likely to have long-lasting effects, including pulmonary fibrosis.[293] Overall, approximately one-third of those investigated after four weeks will have findings of pulmonary fibrosis or reduced lung function as measured by DLCO, even in asymptomatic people, but with the suggestion of continuing improvement with the passing of more time.[291]

The immune response by humans to SARS-CoV-2 virus occurs as a combination of the cell-mediated immunity and antibody production,[294] just as with most other infections.[295] B cells interact with T cells and begin dividing before selection into the plasma cell, partly on the basis of their affinity for antigen.[296] Since SARS-CoV-2 has been in the human population only since December 2019, it remains unknown if the immunity is long-lasting in people who recover from the disease.[297] The presence of neutralizing antibodies in blood strongly correlates with protection from infection, but the level of neutralizing antibody declines with time. Those with asymptomatic or mild disease had undetectable levels of neutralizing antibody two months after infection. In another study, the level of neutralizing antibodies fell four-fold one to four months after the onset of symptoms. However, the lack of antibodies in the blood does not mean antibodies will not be rapidly produced upon reexposure to SARS-CoV-2. Memory B cells specific for the spike and nucleocapsid proteins of SARS-CoV-2 last for at least six months after the appearance of symptoms.[297]

Reinfection with COVID-19 is possible but uncommon. The first case of reinfection was documented in August 2020.[298] A systematic review found 17 cases of confirmed reinfection in medical literature as of May 2021.[298]

Several measures are commonly used to quantify mortality.[299] These numbers vary by region and over time and are influenced by the volume of testing, healthcare system quality, treatment options, time since the initial outbreak, and population characteristics such as age, sex, and overall health.[300]

The mortality rate reflects the number of deaths within a specific demographic group divided by the population of that demographic group. Consequently, the mortality rate reflects the prevalence as well as the severity of the disease within a given population. Mortality rates are highly correlated to age, with relatively low rates for young people and relatively high rates among the elderly.[301][302][303] In fact, one relevant factor of mortality rates is the age structure of the countries populations. For example, the case fatality rate for COVID-19 is lower in India than in the US since India's younger population represents a larger percentage than in the US.[304]

The case fatality rate (CFR) reflects the number of deaths divided by the number of diagnosed cases within a given time interval. Based on Johns Hopkins University statistics, the global death-to-case ratio is 1.99% (5,198,289/261,261,978) as of 28 November 2021.[6] The number varies by region.[305][306] The CFR may not reflect the true severity of the disease, because some infected individuals remain asymptomatic or experience only mild symptoms, and hence such infections may not be included in official case reports. Moreover, the CFR may vary markedly over time and across locations due to the availability of live virus tests.

Total confirmed cases over time

Total confirmed cases of COVID-19 per million people[307]

Total confirmed deaths due to COVID-19 per million people[308]

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Symptoms of Coronavirus: Early Signs, Serious Symptoms and …

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Symptoms of Coronavirus: Early Signs, Serious Symptoms and ...

What we know and don’t know on new COVID-19 variant – pressherald.com

LONDON South African scientists identified a new version of the coronavirus that they say is behind a recent spike in COVID-19 infections in Gauteng, the countrys most populous province.

Its unclear where the new variant first emerged, but scientists in South Africa alerted the World Health Organization in recent days, and it has now been seen in travelers arriving in several countries, from Australia to Israel to the Netherlands.

On Friday, the WHO designated it as a variant of concern, naming it omicron after a letter in the Greek alphabet.

WHAT DO WE KNOW ABOUT OMICRON?

Health Minister Joe Phaahla said the variant was linked to an exponential rise of cases in the last few days.

From just over 200 new confirmed cases per day in recent weeks, South Africa saw the number of new daily cases rocket to more than 3,200 Saturday, most in Gauteng.

Struggling to explain the sudden rise in cases, scientists studied virus samples and discovered the new variant. Now, as many as 90% of the new cases in Gauteng are caused by it, according to Tulio de Oliveira, director of the KwaZulu-Natal Research Innovation and Sequencing Platform.

WHY ARE SCIENTISTS WORRIED ABOUT THIS NEW VARIANT?

After convening a group of experts to assess the data, the WHO said that preliminary evidence suggests an increased risk of reinfection with this variant, as compared to other variants.

That means people who contracted COVID-19 and recovered could be subject to catching it again.

The variant appears to have a high number of mutations about 30 in the coronavirus spike protein, which could affect how easily it spreads to people.

Sharon Peacock, who has led genetic sequencing of COVID-19 in Britain at the University of Cambridge, said the data so far suggest the new variant has mutations consistent with enhanced transmissibility, but said that the significance of many of the mutations is still not known.

Lawrence Young, a virologist at the University of Warwick, described omicron as the most heavily mutated version of the virus we have seen, including potentially worrying changes never before seen all in the same virus.

WHATS KNOWN AND NOT KNOWN ABOUT THE VARIANT?

Scientists know that omicron is genetically distinct from previous variants including the beta and delta variants, but do not know if these genetic changes make it any more transmissible or dangerous. So far, there is no indication the variant causes more severe disease.

It will likely take weeks to sort out if omicron is more infectious and if vaccines are still effective against it.

Peter Openshaw, a professor of experimental medicine at Imperial College London said it was extremely unlikely that current vaccines wouldnt work, noting they are effective against numerous other variants.

Even though some of the genetic changes in omicron appear worrying, its still unclear if they will pose a public health threat. Some previous variants, like the beta variant, initially alarmed scientists but didnt end up spreading very far.

We dont know if this new variant could get a toehold in regions where delta is, said Peacock of the University of Cambridge. The jury is out on how well this variant will do where there are other variants circulating.

To date, delta is by far the most predominant form of COVID-19, accounting for more than 99% of sequences submitted to the worlds biggest public database.

HOW DID THIS NEW VARIANT ARISE?

The coronavirus mutates as it spreads and many new variants, including those with worrying genetic changes, often just die out. Scientists monitor COVID-19 sequences for mutations that could make the disease more transmissible or deadly, but they cannot determine that simply by looking at the virus.

Peacock said the variant may have evolved in someone who was infected but could then not clear the virus, giving the virus the chance to genetically evolve, in a scenario similar to how experts think the alpha variant which was first identified in England also emerged, by mutating in an immune-compromised person.

ARE THE TRAVEL RESTRICTIONS BEING IMPOSED BY SOME COUNTRIES JUSTIFIED?

Maybe.

Israel is banning foreigners from entering the country and Morocco has stopped all incoming international air travel.

A number of other countries are restricting flights in from southern Africa.

Given the recent rapid rise in COVID-19 in South Africa, restricting travel from the region is prudent and would buy authorities more time, said Neil Ferguson, an infectious diseases expert at Imperial College London.

But the WHO noted that such restrictions are often limited in their effect and urged countries to keep borders open.

Jeffrey Barrett, director of COVID-19 Genetics at the Wellcome Sanger Institute, thought that the early detection of the new variant could mean restrictions taken now would have a bigger impact than when the delta variant first emerged.

With delta, it took many, many weeks into Indias terrible wave before it became clear what was going on and delta had already seeded itself in many places in the world and it was too late to do anything about it, he said. We may be at an earlier point with this new variant so there may still be time to do something about it.

South Africas government said the country was being treated unfairly because it has advanced genomic sequencing and could detect the variant quicker and asked other countries to reconsider the travel bans.

Dr. Matshidiso Moeti, WHOs regional director for Africa, commended South Africa and Botswana for quickly informing the world about the new variant.

With the omicron variant now detected in several regions of the world, putting in place travel bans that target Africa attacks global solidarity, Moeti said. COVID-19 constantly exploits our divisions. We will only get the better of the virus if we work together for solutions.

The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institutes Department of Science Education. The AP is solely responsible for all content.

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What we know and don't know on new COVID-19 variant - pressherald.com

COVID-19 Hospital Capacity of NOLAND HOSPITAL TUSCALOOSA …

BIBB MEDICAL CENTERShort Term208 PIERSON AVE, CENTREVILLE, AL 34.0 31.3%9.4 of 30.0 beds used N/A N/A N/A N/A N/A 53 343 UNIVERSITY OF ALABAMA HOSPITALShort Term619 SOUTH 19TH STREET, BIRMINGHAM, AL 1,487.4 88.5%1,226.4 of 1,385.4 beds used 91.6%273.1 of 298.1 beds used 57.1 N/A 18 N/A 927 2,372 ST VINCENT'S BIRMINGHAMShort Term810 ST VINCENT'S DRIVE, BIRMINGHAM, AL 478.9 70.5%317.3 of 449.9 beds used 65.1%54.6 of 83.9 beds used 5.0 N/A 7 N/A 124 707 PRINCETON BAPTIST MEDICAL CENTERShort Term701 PRINCETON AVENUE SOUTHWEST, BIRMINGHAM, AL 303.0 64.9%177.3 of 273.0 beds used 75.6%43.1 of 57.0 beds used 12.9 N/A 5 N/A 151 580 CHILDREN'S HOSPITAL OF ALABAMAChildrens Hospitals1600 SEVENTH AVENUE SOUTH, BIRMINGHAM, AL 418.0 91.6%360.9 of 394.0 beds used 93.1%44.7 of 48.0 beds used N/A 4.3 N/A 5 321 1,477 WALKER BAPTIST MEDICAL CENTERShort Term3400 HIGHWAY 78 EAST, JASPER, AL 187.0 66.5%104.4 of 157.0 beds used 83.3%10.0 of 12.0 beds used 4.1 N/A 5 N/A 93 558 ST VINCENT'S EASTShort Term50 MEDICAL PARK EAST DRIVE, BIRMINGHAM, AL 339.0 87.3%269.9 of 309.0 beds used 91.7%48.6 of 53.0 beds used 8.1 N/A 7 N/A 235 776 FAYETTE MEDICAL CENTERShort Term1653 TEMPLE AVENUE NORTH, FAYETTE, AL 33.0 34.2%8.9 of 26.0 beds used N/A N/A N/A N/A N/A 67 200 HALE COUNTY HOSPITALShort Term508 GREEN STREET, GREENSBORO, AL 26.0 46.2%9.7 of 21.0 beds used N/A N/A N/A N/A N/A 6 205 GRANDVIEW MEDICAL CENTERShort Term3690 GRANDVIEW PARKWAY, BIRMINGHAM, AL 413.4 91.4%357.7 of 391.4 beds used 88.8%82.0 of 92.3 beds used 6.6 N/A 6 N/A 163 739 MEDICAL WEST, AN AFFILIATE OF UAB HEALTH SYSTEMShort Term995 9TH AVENUE SOUTHWEST, BESSEMER, AL 165.9 66.3%110.0 of 165.9 beds used 97.1%20.4 of 21.0 beds used 7.4 N/A N/A N/A 164 1,341 BROOKWOOD BAPTIST MEDICAL CENTERShort Term2010 BROOKWOOD MEDICAL CENTER DRIVE, BIRMINGHAM, AL 372.4 82.0%272.7 of 332.4 beds used 63.4%46.9 of 74.0 beds used N/A N/A N/A N/A 60 653 SELECT SPECIALTY HOSPITAL - BIRMINGHAMLong Term2010 BROOKWOOD MEDICAL CENTER DRIVE, 3RD FLOOR, BIRMINGHAM, AL 38.0 81.3%30.9 of 38.0 beds used N/A N/A N/A N/A N/A N/A N/A NOLAND HOSPITAL BIRMINGHAM II, LLCLong Term50 MEDICAL PARK EAST DRIVE 8TH FLOOR, BIRMINGHAM, AL 24.0 72.1%17.3 of 24.0 beds used N/A N/A N/A N/A N/A N/A N/A GREENE COUNTY HOSPITALShort Term509 WILSON AVENUE, EUTAW, AL 16.0 N/A N/A N/A N/A N/A N/A 8 47 UAB CALLAHAN EYE HOSPITAL AUTHORITYShort Term1720 UNIVERSITY BLVD, SUITE 500, BIRMINGHAM, AL 9.0 N/A N/A N/A N/A N/A N/A N/A 139

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COVID-19 Hospital Capacity of NOLAND HOSPITAL TUSCALOOSA ...

What to know about the omicron variant, a new Covid-19 mutation – Vox

A new Covid-19 variant, now named the omicron variant, was detected in South Africa on Wednesday, prompting renewed concern about the pandemic, a major stock market drop, and the imposition of new international travel restrictions to stop the spread.

Though the variants existence was first reported by South Africa, it has also been found in Belgium, Botswana, Germany, Hong Kong, Israel, Italy, and the United Kingdom, meaning the variant has already spread though how far is unclear, as new cases continue cropping up around the world.

While it will take scientists some weeks to understand the omicron variant, including how quickly it can spread and what the illness from infection with the variant looks like, the World Health Organization has already labeled omicron a variant of concern, which means it could be more transmissible, more virulent, or more able to evade the protection granted by vaccines than the original strain of Covid-19.

More information about the new variant is sure to emerge over the coming days and weeks, but heres what experts are saying so far.

Early evidence suggests that the omicron variant is highly contagious, possibly more so than the delta variant. With more than 30 mutations on the spike protein the part of the virus that binds to a human cell, infecting it omicron could both be more transmissible and have more mechanisms to evade immunity already conferred by vaccines or prior infection.

The mutations would strongly suggest that it would be more transmissible and that it might evade some of the protection of monoclonal antibodies and convalescent plasma, and perhaps even antibodies that are induced by vaccine, Dr. Anthony Fauci, the nations top infectious disease expert, told George Stephanopoulos on ABCs This Week on Sunday.

As Fauci emphasized, however, the vaccines still work, and they are still the best way to protect yourself from the virus.

I dont think theres any possibility that [the omicron variant] could completely evade any protection by vaccine, Fauci said. It may diminish it a bit, but thats the reason why you boost.

So far, cases of the variant have appeared primarily in young people, leaving them exhausted and with body aches and soreness, according to Dr. Angelique Coetzee, head of the South African Medical Association. Were not talking about patients that might go straight to a hospital and be admitted, she told the BBC.

Compared to its pandemic peak, cases in South Africa are relatively low right now. However, the country has still seen a substantial spike in new infections: On Friday, South Africa reported 2,828 new Covid-19 cases, according to the Associated Press, with as many as 90 percent of those cases potentially caused by the omicron variant.

Reinfection is also a concern with the new variant, according to the journal Nature, but at this early stage, its difficult to tell how likely reinfection or breakthrough infections actually are.

The mutation profile gives us concern, but now we need to do the work to understand the significance of this variant and what it means for the response to the pandemic, Dr. Richard Lessells, an infectious disease expert at University of KwaZulu-Natal in Durban, South Africa, said at a South African health ministry press conference on Thursday.

Whether the efficacy of treatments such as monoclonal antibodies and new pill treatments from Pfizer and Merck will be the same against the omicron variant is also unclear, as is the new variants virulence, or how sick it will make those infected, Dr. Leana Wen, a professor of health policy at George Washington University, told CNNs Jim Acosta on Friday.

According to the WHO, the earliest known case of the omicron variant was on November 9, and the mutation was first detected November 24 in South Africa, which has an advanced detection system. While the delta variant is still the dominant strain worldwide and currently accounts for 99.9 percent of cases in the US, the discovery of the omicron variant has coincided with a spike in South African cases a more than 1,400 percent increase over the past two weeks, according to the New York Times.

However, the variant has likely spread far more widely than South Africa, according to Fauci. When you have a virus thats showing this degree of transmissibility & youre having travel-related cases ... it almost invariably is going to go all over, NBC reporter Kaitlan Collins tweeted Saturday, quoting Fauci.

On Friday, President Joe Biden announced new travel restrictions on eight southern African countries, which will take effect on Monday. Travel from Lesotho, South Africa, Eswatini, Namibia, Zimbabwe, Mozambique, Malawi, and Botswana will be restricted, though those restrictions wont apply to US citizens or green card holders, among other groups.

As Wen said on Friday, travel bans dont necessarily do much overall to prevent the spread of the virus, but they can buy time for governments to learn more about diseases and variants and better protect their populations.

Ive decided that were going to be cautious, Biden told reporters on Friday. But we dont know a lot about the variant except that it is of great concern; it seems to spread rapidly.

Other nations including the UK, Australia, Israel, France, and Germany are also restricting travel from southern African nations in an effort to contain the new variant, despite criticism from the South African government.

This latest round of travel bans is akin to punishing South Africa for its advanced genomic sequencing and the ability to detect new variants quicker, South Africas foreign ministry said in a Saturday statement. Excellent science should be applauded and not punished.

As of Saturday the US has not imposed any new travel restrictions on the European or Asian nations where the omicron variant has appeared.

In addition to imminent travel restrictions on a number of southern African nations, Biden urged vaccination and boosters for US citizens as a response to the new variant.

To that end, Biden on Friday also called on wealthy countries with the capability to donate vaccines to do so to low- and middle-income countries, as well as to waive intellectual property rights on current vaccines and treatments so that poorer countries can produce generic versions.

Accessibility isnt the only issue when it comes to a global vaccination campaign, however. Vaccine hesitancy has proven to be a global problem, including in South Africa, where last week the government asked drug companies to delay delivery of new vaccine doses in response to declining demand, despite less than 30 percent of its adult population being inoculated. Europe is presently struggling with a new outbreak at least partly due to its uneven vaccine uptake and vaccine resistance.

Omicron is likely already in the US, given the loosened restrictions on international travel earlier in the month and that the variant dates at least as far back as November 9. And even if its not yet, it soon will be, experts say.

Its not going to be possible to keep this infection out of the country, Fauci told the New York Times. The question is: Can you slow it down?

While there are still many unknowns about the omicron variant, experts agree that its a troubling development in the Covid-19 pandemic.

Weve seen variants come and go, and every month or two we hear about one, Dr. Ashish Jha, dean of the Brown University School of Public Health, told PBS on Friday. This one is concerning. This one is different. There are a lot of features here that have me and many of us concerned about this.

Delta, the current dominant strain of the virus, shows heightened transmissibility and an ability to evade antibodies, as Voxs Umair Irfan explained in June. But as with delta, the key to limiting omicrons spread depends upon human behavior and peoples willingness to engage with proven public health responses.

Stopping the spread also means stopping the possibility of harmful mutations to the virus. Mutations changes to the makeup of the virus are bound to happen, and many of them are harmless to people. The more opportunities the virus has to spread, however, the more chance it has to mutate into a variation that spreads faster, is more resistant to antibodies and treatments, or creates worse health outcomes or even all of these negative traits.

Existing tools, however, should still be effective in stopping omicron PCR tests appear to detect the variant, according to the WHO, and Dr. Francis Collins, director of the National Institutes of Health, told NPR on Friday that there is no data at the present time to indicate that the current vaccines would not work [against omicron].

Additionally, masking and social distancing both are proven strategies to stop the spread of Covid-19, as are getting vaccinated and getting a booster shot.

Those steps are especially crucial as the holiday season and cold weather bring people together indoors, where transmission occurs. According to the New York Timess Covid-19 tracker, cases in the US have increased 10 percent over the past two weeks, with daily averages of new cases over 85,000, hospitalizations over 52,000, and about 1,000 deaths each day. As of November 24, almost 75 percent of vaccine-eligible Americans have received at least one vaccine dose.

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What to know about the omicron variant, a new Covid-19 mutation - Vox

Arizona health experts concerned for holiday COVID-19 surge as travelers arrive back from vacations – FOX 10 News Phoenix

Phoenix travelers react to new COVID-19 variant news

PHOENIX - It was another busy day of travel on Sunday, Nov. 28 as people are now returning home from Thanksgiving vacations, but health experts say this will have an impact on Arizona's already growing COVID-19 cases.

Sunday morning, Sky Harbor International Airport was packed with travelers, but by nighttime, things calmed down.

Since Nov. 21, more than 14 million passengers passed through TSA checkpoints in the U.S. thats more than double compared to 2020.

Health experts warn Arizona COVID-19 cases could increase, and of course, theyre keeping a close eye on the new variant, omicron.

The U.S. will restrict travel for non-U.S. citizens from South Africa and seven other countries starting Nov. 29.

The U.K. government is also tightening restrictions once again as face coverings will be mandatory in shops and public transportation. Travelers returning to the U.K. will require PCR testing and proof of a negative COVID-19 test.

Over in Israel, theyve decided to completely shut their borders to tourists.

Coronavirus in Arizona: Latest case numbers

More restrictions are expected up north. Its been just 20 days since the Canadian border reopened to the U.S. and some travelers say they're expecting changes, again.

Derek Wicks is traveling to Alberta, Canada from Phoenix.

"Seeing that its already spread Belgium, Germany, Hong Kong its a great idea to take precautions, for sure," he said.

Ghalid Ahmed is headed to the same destination and says, "If it happens, it happens. So after all the issues, after almost two years of this, I think you just take it in stride and if theres a fifth wave or sixth wave. or whatever, then so be it. We just take it in our stride."

Charles Kaplan was traveling to New York from Phoenix. He says, "We are all vaccinated and boosted, as was our family here."

Adding, "We will see really how bad it is. Theyre saying be cautious, masks, distance. Maybe theyll make new vaccines, but I think its a little too I mean it can change in weeks, right? But its a little too soon to change what we had to do this week."

The World Health Organization on Sunday urged countries around the world not to impose flight bans on southern African nations due to concerns over the new omicron variant.

WHO's regional director for Africa, Matshidiso Moeti, called on countries to follow science and international health regulations in order to avoid using travel restrictions.

"Travel restrictions may play a role in slightly reducing the spread of COVID-19 but place a heavy burden on lives and livelihoods," Moeti said in a statement. "If restrictions are implemented, they should not be unnecessarily invasive or intrusive, and should be scientifically based, according to the International Health Regulations, which is a legally binding instrument of international law recognized by over 190 nations."

A number of pharmaceutical firms, including AstraZeneca, Moderna, and Pfizer, said they have plans in place to adapt their vaccines in light of the new variant. Pfizer says it expects to be able to tweak its vaccine in around 100 days.

Hand sanitizing stations remain set up around Sky Harbor airport. There are also vending machines that sell protective gear, COVID-19 testing sites and free masks available.

Tip: Check to see if there are any travel restrictions or tests required wherever your traveling to.

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Arizona health experts concerned for holiday COVID-19 surge as travelers arrive back from vacations - FOX 10 News Phoenix