Select Page ::

Fog Computing Market Size Projected to Expand at USD 343.48 Million by 2030 with a CAGR of 55.6% – Report by Market Research Future (MRFR) -…

Posted on July 8, 2022 by Danzig

New York, US, July 05, 2022 (GLOBE NEWSWIRE) -- According to a comprehensive research report by Market Research Future (MRFR), The Fog Computing Market, By Type (Hardware, Software), By Application (Smart Energy, Smart Buildings and Home Automation, Transportation, Healthcare, Smart Manufacturing) - Forecast 2030. The market is expected to touch USD 343.48 million at a 55.6% CAGR by 2030.

Fog Computing Market Overview

Increasing adoption of fog computing solutions for supporting the development of connected cars will boost market growth over the forecast period. From vehicles to vehicles, vehicles to access points, & access points- access points, connected cars display a diverse variety of interactions and connectivity. Fog computing has a number of characteristics that make it an appropriate platform for offering a variety of smart connected vehicle (SCV) services, including safety, traffic support, heterogeneity, mobility & position awareness, low latency, and real-time interactions. Real-time processing in AI is a virtual reality improvement in which the majority of information recovery & processing is transferred to connected devices such as smart home storage, phones, and the cloud. Fog architecture aids these devices in locating and analyzing data by providing an intelligent location hierarchy.

Fog Computing Market Report Scope:

Get Free Sample PDF Brochure:

https://www.marketresearchfuture.com/sample_request/2578

Opportunities

Growing Use of Cloud Computing Platforms to offer Robust Opportunities

The growing use of cloud computing platforms will offer robust opportunities for the market over the forecast period. Fog computing allows IoT devices to do processing, decision-making, and action-taking while only sending relevant data to the cloud. The fog brings the cloud closer to the devices that generate and process IoT data. It solves cloud computing's constraints, such as latency and frequency concerns, scalability issues, and resource management.

Restraints

Lack of Uniform Governance Standards to act as Market Restraint

The lack of uniform governance standards and lack of fog computing technology skills may act as market restraints in the forecast period.

Market Challenges

Privacy & Security Concerns to act as Market Challenge

Privacy and security concerns may act as a market challenge over the forecast period.

Browse In-depth Market Research Report:

https://www.marketresearchfuture.com/reports/fog-computing-market-2578

COVID-19 Analysis

Following the emergence of the Corona virus, practically every industry around the world has pushed toward digitization and automation, & people have begun working from home, prompting enterprises to relocate their workload to the cloud in order to keep their operations running smoothly. As a result, firms are likely to spend higher on IT infrastructure for customer support services and business applications globally in the post-Covid-19 period in order to operate efficiently. Cloud computing, digitization, artificial intelligence, and machine learning are projected to dominate the technological arena in the future years, and investors are developing long-term investment strategies in this area.

Fog Computing Market Segmentation

The global fog computing market is bifurcated based on type and application.

By type, hardware will lead the market over the forecast period.

By application, smart manufacturing will dominate the market over the forecast period.

Talk to Expert:

https://www.marketresearchfuture.com/ask_for_schedule_call/2578

Fog Computing Market Regional Analysis

North America is predicted to domineer the market, accounting for the largest share of the CAGR in the forecast year. Healthcare facilities, smart homes, smart autos, and other applications are driving the fog computing market in North America. In 2017, the Americas market is predicted to have the highest share of the industry. The strong R&D in the fog computing, higher penetration of the Internet of Things, and the creation of a number of IoT and cloud start-ups are the primary driving reasons for growth in the Americas. During the projected period, North America is expected to have the biggest market share in the global fog computing market. This expansion in the region is mostly due to rising spending in the fields of fog computing and IoT penetration and deployment. As a result, an increase in IoT & cloud-based enterprises in the region have fueled market expansion. Fog computing technology is projected to have a huge future in North America. Because of increased investment in fog computing research & development, the existence of significant players, and the increasing adoption of IoT in the region, this region dominates the fog computing market. The market's enterprises will benefit from the improved network infrastructure in various nations across this area. The regional market will benefit from increased expenditures in the development of concepts using sophisticated technologies like AI and IoT.

APAC to Have Admirable Growth in Fog Computing Market

Because of their cost-effective nature, Asia-Pacific countries such as China, Japan, Australia, India, and others have seen the highest number of countries transition to cloud computing & cloud platform usage, paving the way for fog computing technologies. Cloud computing, cloud data centres, the government's growing interest, NGOs, trade allies, private firms, & other organizations have helped the Asia-Pacific region go digital and grow its economy significantly. While the expansion in Asia Pacific is mostly due to businesses' widespread adoption of the cloud platforms to improve efficiency and the government's increased focus on smart cities and smart buildings. Because of government support, the expansion of connected cars, and widespread usage of cloud solutions in emerging countries, Asia-Pacific is predicted to have the greatest CAGR during the projection period of 2021-2028.

The sector is growing because of the necessity to take benefit of hybrid IT infrastructures to give flexibility and agility. Furthermore, the region has seen a significant uptake of cloud services in important markets such as China, Japan, & Australia, creating potential opportunities for fog network implementation. Furthermore, the Indian government's Make in India effort is likely to stimulate smart manufacturing growth, driving up need for streaming the data from cloud to edge. The OpenFog Consortium has formed a partnership with the IoT ITAC to work and test the technology's standards and improvements. Furthermore, the country's growing number of connected cars is likely to raise the demand for an effective data handling & communication platform.

Ask For Discount:

https://www.marketresearchfuture.com/check-discount/2578

Global Fog Computing Market makes a brief note on factors affecting the business growth and development, market growth, and market analysis for the forecast year. It shares the segments and sub-segments on the fog computing market is determined. It classifies the strategic alliances, different joint ventures, new product developments, mergers and acquisitions, research, and developments that made the market for fog computing across the world. It points to the challenges the fog networking market had to suffer and how the Internet of Things is used to maintain and overcome these setbacks.

Competitive Analysis:

Dominant Key Players on Fog Computing Market Covered are:

Related Reports:

Cloud Computing Market Research Report: By Service Model, By Deployment, By Organization Size, By Verticals- Forecast till 2030

Grid Computing Market Research Report, By Components, Graphics Type, by End User, by Application and Forecast till 2030

Cognitive Computing Market: Technology, Deployment, Organization Size, End-User and Forecast till 2030

Cluster Computing Market, by Service Type, by Deployment, By Organization Size, By Vertical - Forecast 2020-2030

About Market Research Future:

Market Research Future (MRFR) is a global market research company that takes pride in its services, offering a complete and accurate analysis regarding diverse markets and consumers worldwide. Market Research Future has the distinguished objective of providing the optimal quality research and granular research to clients. Our market research studies by products, services, technologies, applications, end users, and market players for global, regional, and country level market segments, enable our clients to see more, know more, and do more, which help answer your most important questions.

See the rest here:

Fog Computing Market Size Projected to Expand at USD 343.48 Million by 2030 with a CAGR of 55.6% - Report by Market Research Future (MRFR) -...

Engineering Graduate Fellows Get Hands-on Experience with National Industry Leaders – UCF

Posted on July 8, 2022 by Danzig

Seven University of Central Florida graduate students are currently interning at Adobe and 3M, among other leading employers thanks to fellowships supported by the National Graduate Degrees for Minorities in Engineering Fellowship (GEM) program.

The GEM program began in 1976. The public-private partnership aims to connect students from underrepresented groups with the nations top employers and universities. Those selected receive a $16,000 fellowship from the GEM Consortium, a paid summer internship, and a tuition remission for a masters or doctoral program of their choice. The national program is highly competitive and enables students to be placed in coveted internships with some of the nations industry leaders in STEM.

UCF has been a partner university for more than 20 years. The GEM program is one of several supporting students of color at UCF, a Hispanic Serving Institution.

This years UCF GEM Fellows are:

Novia Berriel 21MS

Currently a researcher in associate professor of materials science Parag Banerjees lab, Novia Berriel will continue her education as a doctoral fellow in materials science. She originally came to UCF because of the so-called two-body problem the need for two professional spouses to find suitable placements in the same area but has since fallen in love with everything the university has to offer.

UCF is at the cutting edge of everything, she says. And being a Hispanic woman, I appreciate that its an HSI.

Berriel earned her masters in physics at UCF in 2021. Since she began the degree in 2018, she has been working to explore atomic layer deposition of thin films. In this capacity, shes been able to engage with different disciplines by producing the films needed for a variety of devices.

The opportunity to be interdisciplinary in your everyday life is one of her favorite aspects of the materials science department at UCF.

You can collaboratively interface with so many other labs, Berriel says. I work in Research Building I, which houses faculty and labs from many different departments. So, Ive been able to meet experts in different disciplines by just walking around.

As a GEM fellow and intern for Lam Research, she hopes to build expertise in semiconductor development and solar cells, while making the most of the chance to research freely, meet other Fellows and embrace interdisciplinary collaboration.

Jeffrey Chan-Santiago

Drawn to UCFs state-of-the-art research at the intersection of computer vision, machine learning and robotics, Jeffrey Chan-Santiago knew it would be the best place to earn his doctorate in computer science.

He already has experience applying self-supervised models to monitor and identify honeybees in their natural habitat, modify architectural plans and more through work he conducts at the University of Puerto Rico, Ro Piedras. He earned a bachelors degree in computer science from the university and is currently completing his masters degree in applied mathematics.

He is also an intern at Raytheon for the summer. There and at UCF, he hopes to enable robots to learn more efficiently and safely.

He says he is grateful to be at one of the first steps of a lifelong career in research, and he plans to become a professor, ideally in Puerto Rico, and help motivate students toward research careers in STEM.

Joseph Green

As a GEM fellow at UCF and an intern for Adobe, Joseph Green hopes to broaden his every horizon.

He received his bachelors degree in computer science in 2020 at Auburn University, and says he is eager to make the transition to highly populated Orlando, which has attractions like Walt Disney World.

Green credits his participation in the GEM Fellowship program to encouragement he received as part of a learning community at Auburn. He says he looks forward to joining similarly supportive communities at UCF. This will be his first time living in an area he doesnt know, but Green says he already knows he will have a great time experiencing a new schools culture.

In the process, he says he will be able to see all the variety his field has to offer.

During his masters program in computer science, he plans to make the most of the opportunity to pursue machine learning, complex networks and other inspiring topics.

Dania Jean-Baptiste

Earning her bachelors degree with honors in computer information systems from Bethune-Cookman University in 2021 made Dania Jean-Baptiste realize how much she enjoyed her field and how much she had left to learn.

To ensure her work would remain at the cutting edge of security standards, Baptiste decided to pursue a masters degree in cybersecurity and privacy. She initially enrolled at Florida A&M University; however, she decided to transfer to another university. Although the transition was difficult, she says having faith helped her continue her path.

So, she applied and was admitted to be a GEM Fellow at UCF. Her fellowship is sponsored by Intel. And this summer, Baptiste is participating in Tech Forward a Salesforce training program that prepares participants from underrepresented groups to earn their certification in network administration.

Baptiste says she looks forward to enriching experiences in research. Her ultimate goal is to learn as much as she can about data analytics, artificial intelligence and cloud computing. Then, she will be able to put her skills to use while giving back to her community.

Andrea Molina Moreno 22 After building a foundation in the different areas of STEM, Andrea Molina Moreno decided to focus on materials engineering.

She says that it has a uniquely broad scope. You can work with anything you choose, since almost everything is material.

Moreno came upon this decision in the midst of several transitions: immigrating from Caracas, Venezuela, transferring from Simn Bolvar University, and graduating among UCFs first cohort of bachelors materials science students.

With the GEM fellowship, she will pursue a doctoral degree in materials science. This summer, she is gaining experience in industry by interning at 3M in Minneapolis. As she continues her education, Moreno most looks forward to serving as a role model for fellow Hispanic female engineers.

What has motivated her so far is the desire to gather as much knowledge as she possibly can. She shares that Ive been studying for so much of my life, and its what I really enjoy doing learning more and more.

Jason Ortiz

The COVID-19 pandemic gave Jason Ortiz an opportunity to pause and think back to some of his original passions.

In 2021, he had already spent three years working as a software engineer at Microsoft in Seattle, where he enjoyed the opportunity to tackle exciting problems in cloud-computing. Still, he had always hoped to further explore 3D applications. Extended reality (XR) encompassing the spectrum of virtual, mixed and augmented reality applications particularly stood out to him.

He says he realized that the fields potential is outstanding. It can address a lot of problems related to isolation, by helping people work in novel ways while still feeling a sense of togetherness. So, he did a bit of research in his downtime.

Thats when Ortiz discovered the pioneering work of UCF Engineering Professor Carolina Cruz-Neira. Even better, Cruz-Neira was teaching in Orlando, his hometown. The GEM Fellowship offered a way to return for his doctorate.

He jumped at the chance. Currently an intern at Argonne National Laboratory, Ortiz will begin as a student at UCF in the fall. He most looks forward to conducting innovative research on collaborative XR and building the teaching skills he began developing as an undergraduate teaching assistant. He is also eager to be the first in his family with a doctorate and hopes to encourage fellow Puerto Ricans to pursue higher education.

Kiaria Tucker

After years of watching crime shows and pointing out technicians as the real heroes, Kiaria Tucker found it easy to decide on a career path.

She remembers that the detectives never actually held my interest. The technicians were the ones who could say This is what happened. This is what the evidence shows. Its thanks to the technicians that they had the evidence they needed to do anything.

Forensic science offered the opportunity for excitement and a tangible impact. So, Tucker received her bachelors degree in chemistry with a forensic concentration from Talladega College. While there, she participated in the McNair Scholars Program, where a mentor encouraged her to apply to the GEM fellowship.

Since her acceptance, Tucker has explored microbiological chemistry research as an intern for Oak Ridge National Laboratory in Knoxville, Tennessee. This fall, she will begin as a thesis-seeking doctoral student in chemistry at UCF. Tucker says she looks forward to earning the skills and certifications that will make her a valuable member of a forensic team. She says from everything shes seen so far, the field still never fails to excite her.

See original here:

Engineering Graduate Fellows Get Hands-on Experience with National Industry Leaders - UCF

Global Cloud Analytics Market to be Worth USD 99.95 Billion at a CAGR of 23.2% by the Year 2027 – Digital Journal

Posted on July 8, 2022 by Danzig

Global Cloud AnalyticsMarketis expected grow at a CAGR of 23.2 percent during 2021-2027,reaching nearly USD 99.95 Billion.

According to a new Maximize Market Research report titledGlobal Cloud Analytics Marketby Store Type, by Application and Region: Industry Overview and Forecast,Global Cloud AnalyticsMarket size was valued at USD 23.20 Billion in 2020, and the total revenue is expected to grow at 23.2 percent through 2021 to 2027, reaching nearly USD 99.95 Billion.

Data on the cloud is analysed usingGlobal Cloud Analyticsto produce helpful data and deeper insights. By obtaining, integrating, analysing, and presenting insights,Global Cloud Analyticsaid in streamlining business processes and enabling organisations to make better decisions for better results.

The examination of theGlobal Cloud Analyticsmarkets growth potential, challenges, and trends is the primary emphasis of the report. In order to understand the effects of numerous aspects on the market forGlobal Cloud Analyticss, including bargaining power of suppliers, competitive intensity of competitors, threat of new entrants, threat of substitutes, and bargaining power of buyers, the study gives Porters five forces analysis.

Request Free Sample:@https://www.maximizemarketresearch.com/request-sample/7883

Global Cloud Analytics Market Dynamics:

The main driver of market expansion forGlobal Cloud Analyticsis the rise in demand among enterprises for actionable insights from cloud-based data. Additionally, it is anticipated that increased enterprise adoption of machine learning and artificial intelligence (AI) will support market expansion. However, a lack of technical knowledge and an inability to comprehend intricate algorithms impede industry expansion. Furthermore, the globalGlobal Cloud Analyticsmarket is anticipated to benefit greatly from the use of cloud-based solutions over on-premises ones.

Global Cloud AnalyticsMarket Segment Insights:

The MMR report presents a comprehensive overview, market shares, and growth opportunities ofGlobal Cloud Analyticsmarket by Store Type, and by Application.

The BFSI, retail and consumer goods, healthcare and life sciences, media and entertainment, government, telecom and IT, research and education, energy, manufacturing, and others are the vertical segments under which the worldwideGlobal Cloud Analyticsmarket is subdivided. In 2020, the BFSI sector had the highest market share (20.12%). Cloud-based technologies are used by fintech companies to improve operational effectiveness and the client experience. The BFSI industry can offer a secure payment service, CRM and ERP system, secure storage of sensitive data, and regulatory compliance thanks to the use ofGlobal Cloud Analytics.

Global Cloud AnalyticsMarket, Key Highlights:

Global Cloud AnalyticsMarket by Region:

In 2021, North America is anticipated to hold the greatest market share forGlobal Cloud Analyticsglobally. The presence of market leaders who provide a variety ofGlobal Cloud Analyticstechnology solutions at affordable prices, the widespread use of social media, and the high adoption of cloud computing services by numerous businesses across all industry verticals are all contributing to the regional growth of theGlobal Cloud Analyticsmarket. However, during the projection period, the Asia-Pacific region is anticipated to develop at the greatest CAGR. The demand forGlobal Cloud Analyticssolutions in the Asia-Pacific area is anticipated to rise as a result of the rising number of start-ups requesting and looking for cloud computing services to manage their businesses efficiently and the expansion and increased use of social media.

Global Cloud AnalyticsMarket Key Players:

Global Cloud AnalyticsMarket Segmentation:

by Solution

by Deployment Mode

by Organization Size

by Vertical

To get a detailed report summary and research scope oftheGlobal Cloud Analyticsmarket, click here:@https://www.maximizemarketresearch.com/market-report/global-cloud-analytics-market/7883/

About Maximize Market Research:

Maximize Market Consulting offers firms complete Market Intelligence (MI) solutions for a variety of products and services, both online and offline. The company provide comprehensive market research studies that analyse both qualitative and quantitative data to assist business solutions to operate better. MMR has industrialised its reputation from the ground up by providing high-quality inputs and nurturing long-term client relationships. MMR are a promising digital MI solutions company that can assist in making commercial speculations a success.

Contact Maximize Market Research:

3rd Floor, Navale IT Park, Phase 2

Pune Banglore Highway, Narhe,

Pune, Maharashtra 411041, India

[emailprotected]

View post:

Global Cloud Analytics Market to be Worth USD 99.95 Billion at a CAGR of 23.2% by the Year 2027 - Digital Journal

Machines with Minds? The Lovelace Test vs. the Turing Test – Walter Bradley Center for Natural and Artificial Intelligence

Posted on July 8, 2022 by Danzig

Non-Computable You: What You Do That Artificial Intelligence Never Will (Discovery Institute Press, 2022) by Robert J. Marks is available here. What follows is an excerpt from Chapter 2.

Selmer Bringsjord, and his colleagues have proposed the Lovelace test as a substitute for the flawed Turing test. The test is named after Ada Lovelace.

Bringsjord defined software creativity as passing the Lovelace test if the program does something that cannot be explained by the programmer or an expert in computer code.2 Computer programs can generate unexpected and surprising results.3 Results from computer programs are often unanticipated. But the question is, does the computer create a result that the programmer, looking back, cannot explain?

When it comes to assessing creativity (and therefore consciousness and humanness), the Lovelace test is a much better test than the Turing test. If AI truly produces something surprising which cannot be explained by the programmers, then the Lovelace test will have been passed and we might in fact be looking at creativity. So far, however, no AI has passed the Lovelace test.4 There have been many cases where a machine looked as if it were creative, but on closer inspection, the appearance of creative content fades.

Here are a couple of examples.

A computer program namedAlphaGo was taught to play GO, the most difficult of all popular board games. AlphaGo was an impressively monumental contribution to machine intelligence. AI already had mastered tic-tac-toe, then the more complicated game of checkers, and then the still more complicated game of chess. Conquest of GO remained an unmet goal of AI until it was finally achieved by AlphaGo.

In a match against (human) world championLee Sedol in 2016, AlphaGo made a surprising move. Those who understood the game described the move as ingenious and unlike anything a human would ever do.

Were we seeing the human attribute of creativity in AlphaGo beyond the intent of the programmers? Does this act pass the Lovelace test?

The programmers of AlphaGo claim that they did not anticipate the unconventional move. This is probably true. But AlphaGo is trained to play GO by the programmers. GO is a board game with fixed rules in a static never-changing arena. And thats what the AI did, and did well. It applied programmed rules within a narrow, rule-bound game. AlphaGo was trained to play GO and thats what it did.

So, no. The Lovelace test was not passed. If the AlphaGo AI were to perform a task not programmed, like beating all comers at the simple game of Parcheesi, the Lovelace test would be passed. But as it stands, Alpha GO is not creative. It can only perform the task it was trained for, namely playing GO. If asked, AlphaGo is unable to even explain the rules of GO.

This said, AI can appear smart when it generates a surprising result. But surprise does not equate to creativity. When a computer program is asked to search through a billion designs to find the best, the result can be a surprise. But that isnt creativity. The computer program has done exactly what it was programmed to do.

Heres another example from my personal experience. The Office of Naval Research contracted Ben Thompson, of Penn States Applied Research Lab, and me and asked us to evolve swarm behavior. As we saw in Chapter 1, simple swarm rules can result in unexpected swarm behavior like stacking Skittles. Given simple rules, finding the corresponding emergent behavior is easy. Just run a simulation. But the inverse design problem is a more difficult one. If you want a swarm to perform some task, what simple rules should the swarm bugs follow? To solve this problem, we applied an evolutionary computing AI. This process ended up looking at thousands of possible rules to find the set that gave the closest solution to the desired performance.

One problem we looked at involved a predatorprey swarm. All action took place in a closed square virtual room. Predators, called bullies, ran around chasing prey called dweebs. Bullies captured dweebs and killed them. We wondered what performance would be if the goal was maximizing the survival time of the dweeb swarm. The swarms survival time was measured up to when the last dweeb was killed.

After running the evolutionary search, we were surprised by the result: The dweebs submitted themselves to self-sacrifice in order to maximize the overall life of the swarm.

This is what we saw: A single dweeb captured the attention of all the bullies, who chased the dweeb in circles around the room. Around and around they went, adding seconds to the overall life of the swarm. During the chase, all the other dweebs huddled in the corner of the room, shaking with what appeared to be fear. Eventually, the pursuing bullies killed the sacrificial dweeb, and pandemonium broke out as the surviving dweebs scattered in fear. Eventually another sacrificial dweeb was identified, and the process repeated. The new sacrificial dweeb kept the bullies running around in circles while the remaining dweebs cowered in a corner.

The sacrificial dweeb result was unexpected, a complete surprise.There was nothing written in the evolutionary computer code explicitly calling for these sacrificial dweebs. Is this an example of AI doing something we had not programmed it to do? Did it pass the Lovelace test?

Absolutely not.

We had programmed the computer to sort through millions of strategies that would maximize the life of the dweeb swarm, and thats what the computer did. It evaluated options and chose the best one. The result was a surprise, but does not pass the Lovelace test for creativity. The program did exactly what it was written to do. And the seemingly frightened dweebs were not, in reality, shaking with fear; humans tend to project human emotions onto non-sentient things. They were rapidly adjusting to stay as far away as possible from the closest bully. They were programmed to do this.

If the sacrificial dweeb action and the unexpected GO move against Lee Sedol do not pass the Lovelace test, what would? The answer is, anything outside of what code was programmed to do.

Heres an example from the predatorprey swarm example. The Lovelace test would be passed if some dweebs became aggressive and started attacking and killing lone bullies a potential action we did not program into the suite of possible strategies. But that didnt happen and, because the ability of a dweeb to kill a bully is not written into the code, it will never happen.

Likewise, without additional programming, AlphaGo will never engage opponent Lee Sedol in trash talk or psychoanalyze Sedol to get a game edge. Either of those things would be sufficiently creative to pass the Lovelace test. But remember: the AlphaGo software as written could not even provide an explanation of its own programmed behavior, the game of GO.

You may also wish to read the earlier excerpts published here:

Why you are not and cannot be computable. A computer science prof explains in a new book that computer intelligence does not hold a candle to human intelligence. In this excerpt from his forthcoming book, Non-Computable You, Robert J. Marks shows why most human experience is not even computable.

The Software of the Gaps: An excerpt from Non-Computable You. In his just-published book, Robert J. Marks takes on claims that consciousness is emerging from AI and that we can upload our brains. He reminds us of the tale of the boy who dug through a pile of manure because he was sure that underneath all that poop, there MUST surely be a pony!

and

Marks: Artificial intelligence is no more creative than a pencil.You can use a pencil but the creativity comes from you. With AI, clever programmers can conceal that fact for a while. In this short excerpt from his new book, Non-Computable You, Robert J. Marks discusses the tricks that make you think chatbots are people.

Notes

1 Selmer Bringsjord, Paul Bello, and David Ferrucci, Creativity, the Turing Test, and the (Better) Lovelace Test, in The Turing Test: The Elusive Standard of Artificial Intelligence, ed. James H. Moor (Boston: Kluwer Academic Publishers, 2003), 215239.

2 David Klinghoffer, Robert Marks on the Lovelace Test, Evolution News and Science Today, Discovery Institute, January 24, 2018.

3 Bringsjord, Bello, and Ferrucci, Creativity. The Lovelace test (LT) is more formally stated by Bringsjord and his colleagues. Here is their definition: Artificial agent A, designed by H, passes LT if and only if (1) A outputs o; (2) As outputting o is not the result of a fluke hardware error, but rather the result of processes A can repeat; (3) H (or someone who knows what H knows, and has Hs resources) cannot explain how A produced o. Notice that this differs from Turings surprises which, as he admitted, occurred because he as programmer erred or else forgot what he had done.

4 Selmer Bringsjord, The Turing Test is Dead. Long Live the Lovelace Test, interview by Robert J. Marks in Mind Matters News, podcast, 27:25, April 2, 2020, https://mindmatters.ai/podcast/ep76/.

Machines with Minds? The Lovelace Test vs. the Turing Test - Walter Bradley Center for Natural and Artificial Intelligence

Upload Season 3 is not coming in July 2022 – Amazon Adviser

Posted on July 8, 2022 by Danzig

We are more than ready to see whats next as it looks like Nathans head is about to explode. When will Upload Season 3 come to Prime Video?

There were a lot of questions at the end ofUpload Season 2. Nathan had been downloaded, but it looks like he only has 24 hours to live. Hes already suffering nosebleeds, which is a sign that hes going to die.

The good news is Taylor rebooted him within the digital world. This Nathan wont have any memories of what happened in the real world, but at least theres a chance to bring him back again.

Now we just need to know when well get to see what is to come next.Upload Season 3 isnt coming in July, though. Thats not surprising with the renewal only just coming in back in May, but it doesnt stop us from looking out for any information about the new season.

We had to wait almost two years for the second season of the series. Part of that was due to COVID and the filming delays in 2020. Filming couldnt start until January 2021. It wrapped in April 2021, but this is a show with a length post-production process. It took almost a year for that to be completed.

With all that in mind, were not looking atUpload Season 3 arriving in 2022 at all. There is a chance well see it by the end of 2023, though. Without the filming delays, we shouldnt have to wait almost two years for the third season. It will be worth the wait, though. That part we know.

At least the writing had started before the official renewal came in. Everyone was pretty confident that this should would be renewed. It will help to keep the wait for production to start to a minimum.

Upload is available to stream on Prime Video.

Read the original here:

Upload Season 3 is not coming in July 2022 - Amazon Adviser

Movin’s predictable logistic flow will give MSMEs peace of mind: UPS’ Ufku Akaltan – Economic Times

Posted on July 8, 2022 by Danzig

Rahul Bhatia-led InterGlobe Enterprises and Atlanta-based logistics major UPS rolled out their logistics venture, Movin, in the capital recently. Aiming to tap the logistics industry in a more predictable, transparent and reliable manner, Movin boasts of helping businesses get more competitive in this space.

With its services that include day-definite as well as time-definite solutions, the venture claims to give businesses better predictability and planning for their operations. Ufku Akaltan, UPS President-Indian subcontinent, Middle East and Africa, and JB Singh, Director,

The Economic Times (ET): Why did you want to do this JV with InterGlobe for the Indian market? What was the idea behind it?Ufku Akaltan (UA): A typical joint venture brings in unique and a wealth of experience to the Indian market. Also in the aviation, hospitality and travel industries, InterGlobe is second to none. They have built enduring brands and they have connected these brands to customers. They were a perfect partner for us to bring Movin to the market together.

ET: Are you creating any physical infrastructure in India?UA: Movin is currently building and expanding its network, starting with our people, technology, processes and also partners. Long-term leases are a part of this game plan to make sure the network is aligned to our customer needs to provide a predictable and reliable service.

ET: How will Movin help in driving more efficiencies in logistic operations for Indias MSME sector?UA: Movin, with its product portfolio and technology driven processes, will be providing MSMEs the peace of mind for a predictable, controllable, plannable logistic flow. It is going to help the MSMEs reach their customers faster, which will improve their chances to grow and, in essence, enhance their cash flows. They will also have a much easier access to global trade and when customers are capable in a domestic environment, they start seeking opportunities to start exporting. At that point, they will integrate with our global network which will further help them grow their business.

ET: Movin seeks to make the supply chain more predictable which, in effect, will help a lot of businesses in the present environment. What kind of technological processes do you have in place to make this possible? JB Singh (JS): Movin will focus on its people, driving commitment through training, engagement and empowerment. Culture drives business, so that is fundamental and becomes a bedrock of our business. We have built the whole indigenised stack in technology. It is almost paperless where you can upload KYCs or any documentation seamlessly. It is really simple to use, which means even someone from a tier-II or a tier-III place can use it. We have a very large robust call centre and we are going to promise single call resolution. There is a whole repository where customers will have their own data on billings and everything which they can access in time.

It is all accessible to customers and it is linked to our entire back office. Everything that we see, the customers can see as well and so it is entirely transparent. Even aspects like our HR policies and how we manage our people everything is integrated into that.

A more important part is the processes. If there are solid processes in place, it drives efficiency and that drives value.

ET: The supply chain crisis has affected economies across the world. In the aftermath of such a crisis, how can such a brand help to alleviate that in some way? UA: When you have predictability and a reliable service from a logistics partner, that helps you surgically support your own customers with such a product. We

Movin's predictable logistic flow will give MSMEs peace of mind: UPS' Ufku Akaltan - Economic Times

Opinion: The unsung heroes of Ukraine: Photographers Evgeniy Maloletka and Mstyslav Chernov, who captured Mariupol’s pain – The Globe and Mail

Posted on July 8, 2022 by Danzig

Associated Press photographer Evgeniy Maloletka points at the smoke rising after an airstrike on a maternity hospital, in Mariupol, Ukraine, on March 9.Mstyslav Chernov/The Associated Press

The Globe and Mail is spotlighting some of the unsung heroes of the war in Ukraine, who are doing their part amid Russias invasion. Other pieces in this series include recognition of the doctors, the farmers and the public servants

Christian Borys is the founder of Saint Javelin, a company that has donated more than $1-million from sales to Ukraine since the start of the war, and a former reporter based in Kyiv from 2014 to 2018.

In February, early in Vladimir Putins unprompted and illegal attack on Ukraine, Russian troops quickly advanced from the south and from the east until they were on the footsteps of the Ukrainian city of Mariupol.

As the Russian military began its siege of the now-infamous port city, there came a moment of reckoning for the foreign aid workers, journalists, photographers and others staying in hotels across the city: whether they should stay or leave.

Most left. But Evgeniy Maloletka and Mstyslav Chernov, both veteran Ukrainian journalists who have covered the war with the Associated Press for years, decided to stay, because they understood what the Russians were about to do to Mariupol. They decided that their job, no matter the personal risk, was to tell that story to the world.

Since 2014, theyve both seen firsthand the depths of depravity within the Russian military. They understood what the Russian military can do and does to journalists who expose their horrors. And they knew that the Russian military would be only too happy to wipe Mariupol off the face of the Earth, killing thousands of civilians, if it meant achieving Russias goals.

Yet they stayed. And by staying the only international journalists who remained in the city, over the course of their month there they became the first journalists to shock the world with the true face of Russia.

With Russias relentless shelling knocking out power throughout the city, they used generators to power their phones and laptops so they could upload their work to Associated Press editors around the world, using whatever weak internet signal was left.

And that work was gruesome and heartbreaking. In late February, they started to send photos of lifeless Ukrainian children in Mariupols hospitals whod been killed by Russian artillery and air strikes. The photos were almost impossible to look at, but Mr. Maloletka and Mr. Chernov bore witness at those hospitals, spending hours with those medical teams, watching countless children and civilians die so that the rest of the world could see what Russia was doing.

The psychological effect of what they saw and experienced is impossible for almost anyone to understand, but they did it day in and day out. They experienced danger themselves, too; Mr. Chernov said the Russians were hunting them down. They had a list of names, including ours, and they were closing in, he wrote.

Over the course of the nearly three-month siege, Mariupol became the home of a humanitarian crisis with thousands of reported deaths. In May, the city fell under Russian control.

The two of them never fired a bullet, but in a very real way, I think that those two men helped to save Ukraine. They may not have fired a bullet, but their photos and videos helped galvanize the worlds support. In my mind, the country still fights on today, in part because of their cameras.

Keep your Opinions sharp and informed. Get the Opinion newsletter. Sign up today.

See the original post:

Opinion: The unsung heroes of Ukraine: Photographers Evgeniy Maloletka and Mstyslav Chernov, who captured Mariupol's pain - The Globe and Mail

How to Resize an Image in Photoshop – PetaPixel

Posted on July 8, 2022 by Danzig

Resizing images in Adobe Photoshop sounds like it should be a trivial and simple operation, and for many uses and users, it is. Its when one starts looking closely at the details in a resized image that it becomes apparent you should be looking into the options of the resize image dialogue box.

In the past resizing to larger sizes was often performed on image files in order to make large prints. With the higher pixel count of current cameras and high-end mobile devices, resizing larger might not seem that necessary and maybe it isnt for many users. If, however, youre looking to produce the best quality prints from your image, resizing before printing might be in order and it doesnt necessarily mean increasing image size.

Another resize scenario that I personally run into nearly every day is prepping images for posting to social media. In this case, Im reducing the size of images in Photoshop before uploading them to social media and my own website. Other reasons for resizing images include submissions for publications, insertion into videos, and many more.

First, well start with a basic, barebones step-by-step look at how to resize an image. The steps are as follows:

Now lets do a deeper dive into the options available when resizing any image.

The Image Size dialogue box (Figure 1) looks pretty simple but theres a bit more here than meets the eye. Lets take a tour of the settings and options starting with the preview window.

In Figure 1 we see the Image resize dialogue box as it normally appears in Photoshop. It can be called by going to the Image > Image Size item in the main menu or by pressing Control+ALT+I in Windows or CMD+ALT+I on Mac.

Starting at the left we have the preview window which by default shows a 100% view of the image being resized. This view will update as one changes the parameters of the resize action to be performed. I highly recommend leaving this setting at 100% as it will provide the most accurate preview of the image quality after the resize is completed.

This preview window by default is a bit small but since 2013, Adobe added the ability to enlarge the entire Image Size dialogue box. It is not readily apparent but you can grab the sides and corners to enlarge the view. You can see in Figure 2 how Ive enlarged the view so now at 100% we can see all of Stephanies face instead of just the small portion visible in Figure 1.

To the right of the preview window are some details about the image starting with the image file size. In this case, the file size is based on an uncompressed file so if you were to save this file as TIFF with compression turned off, it would be 34.4Megabytes in size. Obviously, when the image is exported as a JPEG it would be much smaller in size.

Below this, we have the image dimensions which are by default displayed in inches but might be different if you have changed this in the past. I usually size by pixels which can be seen as my default dimension setting in Figure 3. Other options are percent, inches, centimeters, millimeters, as well as points and picas. The latter two are most familiar to the desktop publishing crowd

Next we have the Fit To options seen in Figure 4. This is a pull-down list with some commonly used image sizes for web use, desktop publishing, and photo print sizes. Keep in mind these presets will not crop an image so if you, for instance, use the preset for 5 x 7 inches and the image doesnt match those proportions it will only match one of the dimensions and let the other adjust to fit the original proportions of the image.

Just below the Original Size option in the pull-down list is Auto Resolution. It might sound like Photoshop will somehow be able to guess the desired resolution for which you are needing. However, it is not reading your mind (yet!). Figure 5 shows the settings that are displayed when selecting this option.

Auto Resolution is basically there to do some math for you when your image will be output via the color separation process (or halftone in the case of grayscale images). If you are having to resize your image for high-quality book publishing or other similar types of output, the printing service will likely provide you with the lines per inch setting you should use. Of course outside the United States you may find they use lines per centimeter and thankfully Photoshop provides this option.

It may also be that you have a printer in your office/studio/lab that might provide a lines/inch type setting recommendation, so check your manual to see if this is the case for the best quality output from your printer.

Three base options are available for draft, good, and best quality. For the final output, I would certainly choose the Best option. Again your service provider might request a draft quality version for testing.

If you have a setting that you need to use frequently but isnt listed in the default options you can use Custom to create one using the Save Preset option. Saved settings can be recalled using the Load Preset option. You will see that if you change the width/height settings the Fit To dialogue will change to Custom (Figure 6) and then this setting can be saved as a new preset.

Now were getting to where the real action is. The width and height fields are where you will make the changes to the image size. In Figure 7, you can see that to the left of the width and height input fields there is a vertical chain link icon (outlined in red). Clicking this icon toggles on and off the link between the two dimensions.

When locked, changing one dimension will cause the other to be changed in order to maintain the original proportions, or aspect ratio, of the image. When turned off these two dimensions can be changed independently. This is often not desirable as it will distort the newly resized image but there are times you might want to do this, thus the option to do so.

Before making changes to the values in the width and height fields you may want to change the type of value youll be modifying. You can do this using the pull-down menu highlighted in yellow in Figure 7. You can see how the options will appear in Figure 8 below.

One thing you might find a bit redundant is that despite the fact that there is a separate pull-down list for both the width and height dimension type, they will almost always be the same. For instance, you cannot have one display in inches and the other display pixels even if you unlock the values using the link icon. The exception is the columns option, which well look at shortly.

Of course, now comes the part where you need to decide which of those values shown in Figure 8 you need to use. Percent is pretty self-explanatory as it simply increases or decreases the image dimensions based on the percentage you input. Keep in mind that there are limits here and you cant set a percentage that will increase the pixel dimensions larger than 300,000 pixels on the long side.

It may seem like the percentage option is rather limited in scope of use as you often need specific pixel/inch/cm dimensions. However, years (and years) ago it was used quite often to enlarge images. Many Photoshop users swore by the method of using successive 10% image size increases to create cleaner and more detailed image enlargements than simply jumping to say 150 or 200 percent image resizes. The more advanced algorithms that are now in Photoshop do a pretty good job. Still, you might try that technique out for yourself and compare the results.

Resizing by pixel dimensions probably runs neck and neck with inches (or centimeters) for the most often used parameter. This certainly is related to needing specific output sizes for viewing on webpages, mobile applications, and other electronic displays.

Note that when resizing for electronic displays, the Resolution parameter will generally have no effect on how the image will look on your computer or mobile device screen. This is because a 400300-pixel image displayed at 100% on a screen will remain 400300 pixels (see Figure 9). It doesnt matter if the resolution is 72ppi or 600ppi. This is because your screen has a fixed number of pixels and as such, the resolution figure means nothing in this case when viewing images, usually.

Some desktop publishing and layout applications may display an image differently based on resolution because they are designed to preview the output to print. As such, Pixels Per Inch do make a difference in this case. The same applies when outputting to print in Photoshop.

This brings us to the remaining value types available for resizing. These include inches, centimeters, millimeters, points, and picas. Using any of these values allows you to resize to a specific output size for printing. For output to a printer, you would typically use the inches or centimeters options. Millimeters could be used here as well. Points and picas are going to be typically used by those in desktop publishing and other publication development tools.

When using these physical print/output values, resolution does become important. While 300ppi is often used for a lot of printing situations, it may not necessarily be the best. 300ppi will often provide very good results for print sizes like 46 up to 1620 inches and maybe even a bit larger. However as output size grows, the expectation is that the viewer will be further away from the image. This is often why large prints, 3040 inches in size, for instance, can be printed at 180ppi and even much less for billboard size prints. Unless someone gets very close to the image, the quality will be very difficult, if not impossible to see.

If you are sending your work to be printed, the service will often offer recommended output resolutions as well as some other settings. If you are using your own printer, the manual might offer some preferred settings based on the output size.

The last item in the list of values is columns. I mentioned columns earlier as the one value you can set in width or height that can be different from the other dimension type. Like picas and points, columns are going to be something familiar to those who layout documents and work in desktop application tools like InDesign. Ok, so what is the actual value of a column when using this value? So glad you asked.

Column size is set in Photoshops preferences and can be found under the Units & Rulers section. By default, the column size is set to 180 points (2.5 inches). Column and gutter width can be adjusted in the area highlighted in red in Figure 10.

This dialogue box also offers some other settings you might want to adjust to suit your workflow. For instance, I prefer to have my rulers set to pixels and you might want to have new images default to a different print resolution than 300ppi.

Before we get into the various resampling options, I want to point out that the terms resize and resample are not necessarily interchangeable. Technically, resizing is simply adjusting the printable output dimensions and as you change the size in inches, the resolution is simply adjusted to fit all the available pixels into the new printable area. You can see this by unchecking the resample box and adjusting the inches value. The resolution will change to fit.

Likewise, you can change the resolution value and the width and height will change accordingly. You will even see that once you uncheck the resample box, the Width, Height, and Resolution labels are all linked and the ability to unlock is not possible. This is because pixels are not being added or subtracted from the image. Of course, if you do need to adjust the actual pixel dimensions of an image, then youll need to check the Resample box if it isnt already.

Here is a brief overview of what the different resampling methods do:

By default, Photoshop will choose what it feels is the best resample algorithm for the resize type you are performing. For enlarging, or adding more pixels, Photoshop is defaulting to Preserve Details where reducing image size uses Bicubic Sharper. The settings Automatic uses could change at any time with future updates so when you get a new update I would check to make sure.

Note: If you dont see the option for Preserve Details 2.0 this could be because you have not enabled it in the preferences. First introduced in Photoshop CC 2018, the Preserve Details 2.0 feature falls under Technology Previews in Photoshops preferences (Figure 13). This is still the case in version 23.4.1 which Im using at the time of this writing. Perhaps in a future version this will get moved into a regular feature.

To take the ambiguity out of the result I would set the method I use manually from the pull-down list. In Figure 14 I have an example image where I doubled the pixel dimensions of the photo using the three different options for enlargement. The large image is a crop at 100% of the original image. The three images below are 100% views of the same point in the image after doubling the pixel count. You can click on the images to see a full-size view of each. At the reduced size to fit into this article, the images are too small to see much if any difference.

I find that Preserve Details 2.0 does the best overall job for clean and natural-looking output. The original Preserve Details does a good job but it tends to over-sharpen a little which creates some halos if you look closely. Bicubic Smoother is no slouch itself and without having the other options side by side for direct comparison. It looks very close at first glance to the Preserve Details options but the fine details are a little mushy and looking at the softbox reflection in the eye you can see some detail in the softbox grid is lost.

For reducing image sizes the Bicubic Sharper does a good job but I have to say most of the options look very good when reducing an images size. If you find that Bicubic Sharper is a little oversharpened, you can try the regular Bicubic option. However, I would still look at Preserve Details 2.0 when the reduction is only between about 1 to 30% of the original dimensions. As always you might just experiment as the content of your image may look better in one approach or the other.

The Bicubic options (Smoother, Sharper, and regular) have a distinct advantage over Preserve Details in that they are much faster to process. If you are needing to resize a large batch of images for proofing or have any other situation where the absolute highest detail isnt necessary, I would use the bicubic options. On my Dell XPS 15 9500 (i7-10875H), upsizing a 42MP image by 200 percent took six seconds with Preserve Details 2.0 and two seconds in the original Preserve Details. Using Bicubic Smoother was pretty much instantaneous.

For illustrations and similar types of images, Nearest Neighbor can do a good job at preserving the solid colors and crisp edges you may find in those types of files. However, it can produce some strong aliasing so watch out for that. Bilinear uses a weighted averaging based on nearby pixels and is the least accurate option. It is also very fast but with modern computers, this advantage really isnt relevant.

One last option in the Image Size dialogue box is in the upper right-hand corner and is just a small gear icon as seen in Figure 15. Scale styles might not sound interesting but if you work with layer styles such as drop shadows, strokes, etc, this option is huge. Layer styles such as drop shadow contain their own set of parameters that dictate their appearance. If the Layer style isnt properly scaled to match the resampled overall image, the effect of the style can be ruined. Having this option for Photoshop to automatically adjust, or not, the Layer Styles in the resampled file is very useful.

Before wrapping this up I wanted to touch on the use of the terms PPI and DPI. These often seem to get used interchangeably but they really shouldnt. PPI refers to the number of pixels per linear inch. This determines how many of the images pixels will be present in the physical space of a print. PPI as it applies to a digital image being displayed on an electronic display doesnt have a specific meaning. In most cases, it has no bearing on how the image is displayed on a screen since when it is viewed at 100% size, it will display the image pixels at a one-to-one ratio to the displays pixels.

Why does this matter?

Sometimes people feel the need to match the PPI setting of their image to the DPI specification of their printer. With printers capable of outputting at DPI levels like 2,400 or 4,800, it can seem like a good idea to upsize your image PPI to match the printer DPI. The fact is that there is usually not a direct correlation to output resolution here. These high DPI output printers use very tiny dots of ink to mix together to create more accurate colors and a wider variety of ink density. As such this is typically not going to help and can actually make the output worse. Plus it can have the detrimental side effect of creating huge file sizes that can be difficult to work with. Instead, stick with your printer manuals recommendation.

So it turns out that resizing images may not be as simple as it appears. Of course, this depends on how important the quality of the final output is to the image usage. I regularly hear from fellow photographers that they are often disappointed in the quality of the images they upload to social media sites like Instagram and Facebook. Often this comes from the fact they are uploading very large images and letting the servers at these services resize the images as they upload. This is usually due to the fact those servers use simple and fast approaches to resizing the images since processing time is money.

Remember earlier how I pointed out how resampling using Preserve Details 2.0 took several seconds vs Bicubic which was nearly instant? If you had to process 350,000,000 photos a day like Facebook does on average, youd probably want to go for the fastest option too. By resizing your images to the recommended size(s) for the site you are using, you improve the quality of the images after they upload.

View original post here:

How to Resize an Image in Photoshop - PetaPixel

Molecular Medicine (M.Sc.) – Georg-August-Universitt Gttingen

Posted on July 8, 2022 by Danzig

The English-language Master's degree programme in Molecular Medicine is directed at highly motivated students from home and abroad who are interested in the subject. The prerequisite is a Bachelor's degree with a focus on either natural sciences or molecular medicine. The degree programme will provide deeper knowledge of topics relating to molecular medicine and clinical theory such as immunology, oncology, genetics, pharmacology and cell biology. In addition, there are also three laboratory internships, each lasting eight weeks. A Master's thesis will be written within six months.

Name of program: Molecular MedicineDegree: Master of Science (M.Sc.)Length of program: 3 semestersProgram start: winter semester onlyApplication deadline: May 30th for winter semester 2021/22 Prerequisites: B.Sc. in Molecular Medicine or a related fieldAdmissions: limited spaces available (apply directly through faculty)Language requirements: English (certification mandatory)

A proof of measles protection is required for enrollment. The form must be completed by your primary care physician.

If necessary, please use the time between your application and enrollment to get vaccinated or to refresh your vaccination status. The short period of time for acceptance after admission is usually not sufficient for this.

For inquiries, please contact the Office of the Dean of Medical Studies studiendekanat@med.uni-goettingen.de.

Program OverviewThe eighteen-month Masters program in Molecular Medicine expands upon the scientific and medical knowledge basis acquired in Bachelor programs and explores in depth the molecular aspects of medicine. Its goal is to train students thoroughly in an area of application of molecular medicine. It should enable students to engage in independent and creative research at the crossroads of medicine and basic science.

Program StructureDuring the first year, students attend the course ?Molecular-pathological aspects of organ systems?, which is designed to heighten their understanding of the interaction between clinical and molecular science. In other obligatory module courses particular aspects of molecular immunology, bacteriology, human genetics and oncology are treated. The final six months are to be devoted to work on a master?s thesis.

A graduate of the Master?s program in Molecular Medicine should have solid knowledge of the methods of scientific research as well as be able to apply a wide spectrum of molecular-medical methods to provide concrete solutions to scientific problems.

Our graduates secure positions in all areas of medical research, laboratory diagnostics, and medical biotechnology, in both the academic and the commercial sectors. Places of employment include: clinics (molecular and biochemical diagnostics, clinical research, etc.); government agencies (criminal investigation offices, public health departments, commercial regulatory authorities, environmental protection agencies, medical associations); places of academic research (universities, Max Planck Institutes and other large research institutions); industrial settings (biomedical technology, production and quality control, basic research and development, publishing, marketing, administration); private laboratories (molecular diagnostics and analysis, environmental protection); and other institutions (ministries, research advancement organizations, technology transfer facilities).

See the rest here:

Molecular Medicine (M.Sc.) - Georg-August-Universitt Gttingen

School of Medicine – Biochemistry and Molecular Genetics | UAB

Posted on July 8, 2022 by Danzig

Committed to exploring new frontiers in basic and translational research.

The Department of Biochemistry and Molecular Genetics is an integral part of the vibrant biomedical research community at the University of Alabama at Birmingham (UAB). UAB ranks among the top public institutions of higher education in terms of research and training awards. Research conducted by the faculty, staff, and students of the Department of Biochemistry and Molecular Genetics is currently supported by more than $7.1 million per year in extramural, investigator-initiated grants.

The Department of Biochemistry and Molecular Genetics carries out cutting-edge basic and translational research. Research strengths in the department includes cancer biology, chromatin and epigenetic signaling, metabolism and signaling, regulation of gene expression, structural biology, DNA synthesis and repair, and disease mechanisms.

Graduate students and postdoctoral fellows in the Department of Biochemistry and Molecular Genetics are trained to carry out hypothesis-driven research using advanced research techniques. This training will prepare our graduates for a career in not just biomedical research, but also in other diverse fields that require critical thinking. Our faculty also proudly trains professional (MD, DDS, & DO) students, as well as undergraduate students at UAB.

View post:

School of Medicine - Biochemistry and Molecular Genetics | UAB

Married Couple are ‘Heart and Soul’ of Willed Body Program – University of Arizona

Posted on July 8, 2022 by Danzig

Medical students around the country start their journey to become physicians by studying the human body in gross anatomy labs, where they are reminded that real people volunteered their bodies to serve as educational tools to train them to help others.

Its no different at the University of Arizona Colleges of Medicine Tucson and Phoenix. The Tucson-based Willed Body Program annually accepts 150-200 whole body donations, which are embalmed and put in cold storage for use by both colleges for up to two years. Afterward, the remains are cremated and ashes returned to the families or spread in nearby mountains.

The people of Arizona are incredibly generous in this respect, because I know some willed body programs do have issues with not enough donors. And we never do, said Jean Wilson, PhD, program director, anatomy instructor, professor of cellular and molecular medicine, and BIO5 Institute member. We always have enough every year to supply the needs of the college and beyond.

The Willed Body Program serves more than just the Colleges of Medicine Tucson and Phoenix. It also supplies bodies for the A.T. Still University School of Osteopathic Medicine in Phoenix and nursing programs at the UArizona College of Nursing, Arizona State University and Northern Arizona University.

Currently, about 9,000 Arizonans have been issued willed body donor cards through the program that was founded in 1967.

Dr. Wilson credits the programs success in large part to the respectful, professional tone set by its funeral directors, Jared and Kat Alvarado. The husband-and-wife team work with donors, the families, faculty, physicians, nurses, students and others who benefit from the program.

Theyre unbelievable, Dr. Wilson said of the Alvarados. In the 32 years Ive been affiliated with the program, weve had people who are fine. But between the two of them, Kat and Jared are exceptional. Theyre so good with the donor families and the donors. They know exactly the right things to say. Theyre very gentle and empathetic. We are super lucky to have them.

Jared has been with the program 12 years, and Kat for seven. Both hold associates degrees in mortuary science and served three-year apprenticeships before being licensed as morticians.

Ive worked at places without an in-house willed body program, where you deal with a third party, said James Proffitt, PhD, College of Medicine Tucson lead instructor for the gross anatomy lab and cellular and molecular medicine assistant professor. Having two trained funeral directors and morticians people who really understand the process of grief and dying makes this so much more community oriented, humanistic, engaging and empathetic with what donors and students need.

I take the same approach as if I were at a funeral home, but feelings surrounding death are slightly less intense. The donors who participate in the Willed Body Program want to be here and most express their excitement at being able to contribute to medical education.Kat Alvarado, UArizona Willed Body Program funeral director, embalmer and coordinator

The donor families are very used to working with Kat and Jared, Dr. Proffitt said. They understand their best interests are looked out for by those two. It creates this kind of community, this family of donors. And this is something I try to impress on our students. These donors arent people from somewhere else. Theyre Arizonans. Theyre our neighbors.

Kat said her interest in the field was piqued in college, when she worked as a funeral home service attendant. She later served as an embalmer, cremationist and funeral director for a funeral home.

At UArizona, she said, I take the same approach as if I were at a funeral home, but feelings surrounding death are slightly less intense. The donors who participate in the Willed Body Program want to be here and most express their excitement at being able to contribute to medical education.

Unlike his wife, Jared said he sort of fell into his career as a funeral director.

After he graduated from high school, he took a job answering the phone at a funeral home. He started working with decedents his second day on the job. He went to mortuary school in Dallas, apprenticed in Texas and Arizona, and served as a crematory operator and embalmer before joining the Willed Body Program.

Death is hard on the families. But, at the same time, its great to hear how proud they are of their loved one donating their body to students for education, Jared said of what families say when he and Kat pick up a donated body. They hear similar comments at an annual willed body ceremony that offers donor families a chance to honor their loved ones.

Nearly 400 people attended the Willed Body Memorial Service in March. Among the speakers were the Alvarados, Dr. Wilson and medical students who expressed their gratitude for the donors beautiful and lasting gift to help them better learn their craft.

Jared does outreach to local high schools, talking to students about his experiences while encouraging others to follow in his footsteps.

My outreach to youth is important to me, he said. I wish I had someone who came to my high school to speak about these types of professions. Its my way of helping out as best I can.

The Alvarados are more than morticians. They also help fulfill continuing education needs for faculty physicians and nurses. In 2015, Jared Alvarado won the College of Medicine Tucsons Appointed Personnel Lura Hanekamp Award of Excellence for the part he plays in education for students, physicians and health professionals.

In 2019, Kat won a UArizona Individual Award for Excellence for her dedication to handling the programs administrative needs as Willed Body Program coordinator.

Jared also helps write academic papers related to the program, including a 2019 article on donor bodies used for students teaching students as a novel solution to time demands on doctors.

The program also hosts training opportunities for other medical professionals where staff need to understand human anatomy, including paramedics, emergency medical technicians and military health personnel. Jared assists in some training, including non-UArizona instruction for Davis-Monthan Air Force Base staff.

It usually is just myself and their instructors, so Im able to show them techniques and things Ive learned as part of the College of Medicine, he said.

Both are on call 24/7 to ensure the Willed Body Programs ongoing success, whether that involves working with instructors to help design specific training or traveling across the state to pick up donor bodies from a family or funeral home.

Thats important, Dr. Proffitt said, because donors bodies are the canvas upon which students and trainees learn to practice their art as healers. Without them, there is no healers art.

Married Couple are 'Heart and Soul' of Willed Body Program - University of Arizona

Ulcerative Colitis (UC) Treatment Market: Rise in Number of Patients with Ulcerative Colitis Globally to Drive the Market – BioSpace

Posted on July 8, 2022 by Danzig

Wilmington, Delaware, United States, Transparency Market Research Inc.: Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) that involves the chronic inflammation of the colon or large intestine. It causes ulcers (sores) and long-lasting inflammation in the digestive tract and typically affects the innermost lining of the colon and rectum. The symptoms of the condition include dehydration, pus or blood in diarrhea, belly pain, fever, and urgent and painful bowel movements. Though the exact cause of the condition has not been identified, abnormal activation of the immune system in an individuals intestines leads to ulceration portions and chronic inflammation of the colon.

Read Report Overview - https://www.transparencymarketresearch.com/ulcerative-colitis-treatment-market.html

Ulcerative colitis can be classified into ulcerative proctitis, proctosigmoiditis, left-sided colitis, pancolitis, or universal colitis and fulminant colitis according to the degree of inflammation and its location. Inflammation in ulcerative proctitis is limited to the rectum. In proctosigmoiditis, inflammation is observed in the sigmoid colon and rectum. Inflammation from the rectum extending to the left colon takes place in left-sided colitis. In universal colitis or pancolitis, inflammation affects the entire colon. Fulminant colitis is a severe but rare form of universal colitis.

Rise in number of patients with ulcerative colitis globally is a prominent factor driving the expansion of the ulcerative colitis treatment market. According to a report published in the Crohns & Colitis Foundation of America (CCFA), around 1.6 million people in the U.S were affected with IBD in 2014, with 70,000 new cases reported each year. Of the total number of people with IBD in the U.S, 907,000 had ulcerative colitis.

Request Brochure of Report - https://www.transparencymarketresearch.com/sample/sample.php?flag=B&rep_id=47604

The number of new cases of UC are reportedly rising rapidly in newly industrialized countries in Eastern Europe, South America, Africa, and Asia. Increase in use of antibiotics, westernized dietary patterns, rise in exposure to pollution, and improvement in hygiene are some of the factors playing a pivotal role in the increased incidence of UC in developing countries as compared to developed countries. The highest increase in the incidence of these conditions has been reported in countries such as Japan, India, China, etc.

New collaborations and partnerships between biopharmaceutical companies is also helping in providing novel treatment options for the management of UC. In February 2018, Cook Biotech Inc. entered into a new partnership with Regentys in order to develop a new treatment for UC. As per the agreement, Cook Biotech will develop and produce Regentys ECMH Rectal Solution (extracellular matrix hydrogel), a patented and non-surgical hydrogel therapy for patients suffering from ulcerative colitis. In December 2017, Roche announced a collaborative agreement with Boehringer Ingelheim for the discovery and manufacture of novel LNA (locked nucleic acid) oligonucleotides used in the management of inflammatory bowel diseases such as UC.

Get COVID-19 Analysis on Ulcerative Colitis (UC) Treatment Market - https://www.transparencymarketresearch.com/sample/sample.php?flag=covid19&rep_id=47604

The global ulcerative colitis treatment market can be segmented based on treatment, end-user, and geography. In terms of treatment, the ulcerative colitis treatment market can be divided into

non-surgical and surgical. The non-surgical segment can be further classified into 5-aminosalicylic acid, corticosteroids, immunosuppressants, and others. Based on end-user, the ulcerative colitis treatment market can be divided into hospitals, ambulatory surgical centers, and clinics.

In terms of geography, the global ulcerative colitis treatment market can be segmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. North America dominates the global ulcerative colitis treatment market due to a sizeable population with UC along with continued funding for development of new therapeutics for the treatment of the condition.

Make an Enquiry Before Buying - https://www.transparencymarketresearch.com/sample/sample.php?flag=EB&rep_id=47604

North America is followed by Europe. Infusion of fresh capital by private investment firms in companies involved in the research of innovative treatment methods for UC is likely to propel the ulcerative colitis treatment market in Europe. In May 2018, Sublimity Therapeutics Limited, a specialty pharmaceutical company, announced that it had successfully raised US$ 64 Mn from investment firms led by Longitude Capital, OrbiMed, and HBM Healthcare Investments. The proceeds from the capital raised will be used for the clinical development of STI-0529 for the treatment of moderate to severe UC.

Prominent players operating in the global ulcerative colitis treatment market are Boehringer Ingelheim, Cook Biotech Inc., Pfizer, Inc, Regentys, and Sublimity Therapeutics Limited.

More Trending Reports by Transparency Market Research

Nanomedicine Market: Nanomedicine Market (Application: Cardiovascular, Anti-inflammatories, Anti-infectives, Neurology, Oncology, and Others) - Global Industry Analysis, Size, Share, Growth, Trends, and Forecast, 2021-2028

Smart Medical Devices Market: Smart Medical Devices Market (Product Type: Diagnostic & Monitoring Devices, Therapeutic Devices, Injury Prevention & Rehabilitation Devices, and Others; Modality: Portable, Wearable, and Others; and End-user: Hospitals, Clinics, Home Care Settings, and Others) - Global Industry Analysis, Size, Share, Growth, Trends, and Forecast, 2021-2028

Bioinformatics Market: Bioinformatics Market (Platforms, Tools, and Services: Platforms, Tools, and Services; and Application: Preventive Medicine, Molecular Medicine, Gene Therapy, Drug Development, and Others) - Global Industry Analysis, Size, Share, Growth, Trends, and Forecast, 2021-2028

Taurine Market: Taurine Market (Type: Food Grade and Pharmaceutical Grade; Application: Health Care Products, Pet Food, Beverage, and Others; and Form: Tablets/Capsules, Liquid-based Serum, and Others) - Global Industry Analysis, Size, Share, Growth, Trends, and Forecast, 2021-2031

Telehealth Market: Telehealth Market (Component: Hardware, Software, and Services; Application: Radiology, Cardiology, Urgent Care, Remote ICU, Psychiatry, Dermatology, and Others; and End-user: Payers, Providers, Patients, and Others) - Global Industry Analysis, Size, Share, Growth, Trends, and Forecast, 2021-2028

Medical Device Technologies Market: Medical Device Technologies Market (Device Type: Cardiology Devices, Diagnostic Imaging Devices, Orthopedic Devices, Ophthalmology Devices, Endoscopy Devices, Diabetes Care Devices, Wound Management Devices, Kidney/Dialysis Devices, Anesthesia & Respiratory Care Devices, and Others; and End-user: Academics & Research, Hospitals, Clinics, Diagnostic Centers, Ambulatory Surgical Centers, and Others) - Global Industry Analysis, Size, Share, Growth, Trends, and Forecast, 2021-2028

Animal Healthcare Market: Animal Healthcare Market (Product Type: Pharmaceuticals, Feed Additives, and Vaccines; and Animal Type: Companion Animals and Production Animals) - Global Industry Analysis, Size, Share, Growth, Trends, and Forecast, 2021-2028

Erectile Dysfunction Drugs Market: Erectile Dysfunction (ED) Drugs Market (Drug: Viagra, Cialis, Staxyn/Levitra, Stendra/Spedra, and Others; and Distribution Channel: Hospital Pharmacies, Retail Pharmacies, and Online Pharmacies) - Global Industry Analysis, Size, Share, Growth, Trends, and Forecast, 2021-2028

About Us

Transparency Market Research, a global market research company registered at Wilmington, Delaware, United States, provides custom research and consulting services. Our exclusive blend of quantitative forecasting and trends analysis provides forward-looking insights for thousands of decision makers. Our experienced team of Analysts, Researchers, and Consultants use proprietary data sources and various tools & techniques to gather and analyze information.

Our data repository is continuously updated and revised by a team of research experts, so that it always reflects the latest trends and information. With a broad research and analysis capability, Transparency Market Research employs rigorous primary and secondary research techniques in developing distinctive data sets and research material for business reports.

For More Research Insights on Leading Industries, Visit Our YouTube Channel and hit subscribe for Future Update - https://www.youtube.com/channel/UC8e-z-g23-TdDMuODiL8BKQ

Contact

Rohit BhiseyTransparency Market Research Inc.CORPORATE HEADQUARTER DOWNTOWN,1000 N. West Street,Suite 1200, Wilmington, Delaware 19801 USATel: +1-518-618-1030USA Canada Toll Free: 866-552-3453Website: https://www.transparencymarketresearch.comBlog: https://tmrblog.comEmail: sales@transparencymarketresearch.com

Read the original post:

Ulcerative Colitis (UC) Treatment Market: Rise in Number of Patients with Ulcerative Colitis Globally to Drive the Market - BioSpace

The pandemic has eroded Americans’ trust in experts and elected leaders alike, a survey finds. – The New York Times

Posted on July 8, 2022 by Danzig

Dr. Rochelle Walensky, director of the Centers for Disease Control and Prevention, testified before a Senate hearing in June.Credit...Haiyun Jiang The New York Times

As the coronavirus pandemic entered its third year, the American public had lost much of its trust both in public health experts and in government leaders, and was less worried than before about Covid-19, according to a survey conducted in early May and released Thursday by the Pew Research Center.

Confidence ratings for public health officials, like those at the Centers for Disease Control and Prevention; for state and local elected officials; and for President Biden fell in a range from 43 percent to 54 percent in the survey much lower than during the early stages of the pandemic.

The survey found a wide partisan gap in attitudes. Overall, 52 percent of respondents said that public health officials had done an excellent or good job at managing the pandemic. But while 72 percent of Democrats in the survey said they felt that way, only 29 percent of Republicans did.

Democrats were also more likely than Republicans 67 percent to 51 percent to say they had at least some confidence in how prepared the nations health care system was to address a future global health emergency.

Dr. Yvonne Maldonado, a pediatric infectious disease physician at Stanford Medicine who chairs the American Academy of Pediatrics committee on infectious diseases, said the pandemic only widened the countrys partisan divide over those issues.

I think that mistrust in government and politicians, and even to a certain extent science, started well before the pandemic, and it just was exacerbated, Dr. Maldonado said.

Pandemic fatigue and a growing notion that Covid is now a part of everyday life probably played a role in the changing public attitudes identified in the Pew survey, according to Dr. Robert Wachter, a professor and the chair of the medicine department at the University of California, San Francisco.

I think peoples thinking is very much influenced by the fact that the chances youre going to die of Covid have gone down substantially on a per-case basis, Dr. Wachter said.

Public confidence in medical centers and hospitals remained high: Eight out of ten respondents said those institutions were continuing to manage the pandemic well, a small decline from 88 percent two years ago.

The survey found that Americans have grown less worried about catching the virus or unintentionally spreading it to others. Most respondents said they thought the worst of the pandemic was over, and only about a quarter saw the coronavirus as a significant threat to their personal health, down from 30 percent in January.

The average number of new confirmed cases reported daily across the United States surged to record highs in January, driven by the Omicron variant. The surge receded swiftly as the winter ended, but the average started to rise again in the spring. In recent weeks since the survey was taken, the number of new confirmed cases has been around 100,000 a day, according to a New York Times database.

Those figures are thought to understate the true number of infections, however, because of increasing reliance on at-home testing, the closings of mass testing sites and reduced frequency in data reporting by states. New deaths have fallen significantly since the winter surge, and Covid now kills fewer than 400 people daily in the United States.

Though many people are still becoming infected, survey data shows that public concern about the virus has declined substantially. The Pew survey found that 76 percent of respondents in May thought the worst of the pandemic was over, compared with about half in January.

Thats the first time during the entire outbreak that weve had a majority of Americans saying this, said Alec Tyson, an associate director of research at the Pew Research Center and a lead author of the survey.

A narrow majority of respondents in the latest survey 55 percent said they thought vaccination had been somewhat or very effective at curbing the spread of the coronavirus. About half felt that way about wearing masks indoors. Respondents were more skeptical about the efficacy of people staying at least six feet apart indoors, with only 34 percent considering that practice at least somewhat effective.

The survey found very wide partisan gaps in attitudes toward all those preventive measures, especially mask-wearing, with Republicans far more likely than Democrats to say they did little or no good.

The poll included 10,282 adults who were surveyed online between May 2 and May 8.

$30 Million Funding Empowers All-in-One Vaccine Candidate to Tackle Future Coronaviruses – Precision Vaccinations

Posted on July 8, 2022 by Danzig

(Precision Vaccinations)

As of early July 2022, uncertainty persists as SARS-CoV-2 coronavirus mutations continue emerging. According to the World Health Organization, the Omicron BA.x variants are now dominant worldwide.

There is a clear need for strategies to tackle emerging variants and protect populations against potential future threats to human health, says vaccine researchers from the University of Oxford and Caltech.

A new consortium announced on June 5, 2022, aims to address these issues by establishing the first-in-human clinical proof of concept for a new vaccine design.

The consortium brings together researchers from the University of Oxford and Caltech to collaborate with deep tech innovation organization CPI and industrial biotechnology company Ingenza Ltd (Caltech-CPI-Oxford-Ingenza).

The Coalition for Epidemic Preparedness Innovations (CEPI) will partner with the consortium and has announced up to US $30 million to fund pre-clinical studies, GMP manufacturing, and Phase 1 trial based on this technology.

The vaccine will target both SARS-CoV-2 and several related bat viruses which have the potential to spread to humans. It builds on technologies developed by the Molecular Immunology Group at the University of Oxford and by the Bjorkman Group based at Caltech led by Professor Alain Townsend at the MRC Human Immunology Unit and Professor Pamela Bjorkman, respectively.

In contrast to many existing vaccine designs that use mRNA or a viral vector to present sections of the spike protein of a single type of virus to the immune system, this new vaccine will use protein nanoparticles containing a protein glue to attach related antigenic sections of the spike proteins from eight different viruses. By incorporating a mosaic-8 vaccine design created at Caltech, these nanoparticles would favor immune responses to the shared parts of each type of coronaviruses within a single vaccine.

Evidence published today in Science by the researchers demonstrates that this vaccine technology elicits protective immune responses against SARS-like viruses but also against some coronaviruses not presented in the trial vaccine. This suggests that the technology could protect against future novel SARS-CoV-2 variants and as-yet-undiscovered coronaviruses with the potential to spill over from animal populations.

Alain Townsend, Oxford Lead of the consortium, Professor of Molecular Immunology at the MRC Weatherall Institute of Molecular Medicine, University of Oxford, said:

The evolution of this consortium is an example of collaborative science at its best. We had been deeply impressed by the power of the glue for sticking proteins together developed by Mark Howarth (Biochemistry Oxford) and derived from his beautiful basic science investigations of the Streptococcus pyogenes bacterium.'

Together, we used this technology to make a prototype nanoparticle SARS-CoV-2 vaccine that induced highly potent responses in preclinical studies.'

Through connections made by Ian Wilkinson (Absolute Antibody), we joined with colleagues at Ingenza and CPI who succeeded in making a fully functional version of the vaccine produced in microbes, thus reducing the cost of production. In addition, we have been collaborating with Prof. Pamela Bjorkman and the Caltech team, who had independently developed the brilliant concept of the mosaic version of the vaccine and are excited to continue working with this world-class consortium.

The consortium partners are committed to equitable access to the project's outputs.

Dr. Jack Tan, Project Manager (Oxford) of the consortium, Senior Postdoctoral Scientist at the MRC Weatherall Institute of Molecular Medicine, said:

We are delighted to work with CEPI to further this nanoparticle technology to produce efficacious, low-cost, infrastructure-independent vaccine that will be accessible to low- and middle-income countries.

Dr. Richard Hatchett, CEO of CEPI, commented in a press release issued on July 6, 2022, There have already been three serious coronavirus epidemics or pandemics in the 21st century and COVID-19 continues to have a devastating impact on the worlds health, society, and economy. Creating vaccines that could provide broad protection against emerging COVID-19 variants and future coronavirus threats would not only help mitigate the damaging effects of another COVID-19-like pandemic, but it could also help reduce the time taken and funding spent continually updating vaccine formulations.

Thats why we are delighted to partner with this CPI-led research consortium to build on Wellcome Leaps initial investment to further advance this pioneering mosaic nanoparticle vaccine technology that, if successful, could work towards consigning the threat posed by coronaviruses to the history books.

The consortium aims to commence a Phase 1 trial in 2024, led by the Oxford Vaccine Group.

PrecisionVaccinationspublishes fact-checked, research-based news curated for mobile readership.

The rest is here:

$30 Million Funding Empowers All-in-One Vaccine Candidate to Tackle Future Coronaviruses - Precision Vaccinations

Epic, Caris Life Sciences working together on molecular testing integration – Healthcare IT News

Posted on July 8, 2022 by Danzig

Caris Life Sciences announced this week that it will be broadening its partnership with Epic, integrating its molecular testing portfolio with Epic's Orders and Results Anywhere network.

WHY IT MATTERSCaris offers whole exome and whole transcriptome sequencing, and by applying AI modeling to its clinico-genomic database, it can help researchers gain better insights into the molecular complexity of disease.

The new project builds on the existing integration of Caris' Genomics Module within Epicand will expand capabilities by offering easier ordering and receipt of molecular profiling results directly in patients' electronic health records.

Officials say Caris' whole suite of molecular profile services for tissue and blood samples will be available within the Orders and Results Anywhere network.

ORA network integration, expected to be available later this year, will help drive data-driven decision-making for Epic customers which represent 60% of oncologists nationwide, the companies note. By putting ordering and results directly into the network, Caris says it aims to offer more streamlined access to structured genomic data within the Epic environment.

THE LARGER TRENDThis is just the most recent in a string of announcements involving Epic and precision medicine technology developers. In June, Myriad Genetics announced it was working to integrate its genetic testing services within Epic's EHR workflows offering providers genetic insights for more personalized care and giving patients easier access to test results within MyChart.

In April, Guardant Health, which develops precision oncology tools,announced its own collaboration with Epic to streamline clinicians' ability to order Guardant blood tests, liquid biopsies and more within the EHR.

And this past August, Foundation Medicine announced a deal with Epic toadd its genomic profiling and testing services to the EHR workflow.

In other Epic news, the vendor announced this past month that it would join the Trusted Exchange Framework and Common Agreement and apply to connect to TEFCA as an inaugural Qualified Health Information Network.

ON THE RECORD"Caris Life Sciences is committed to fulfilling our organizational promise of making personalized precision medicine accessible to as many physicians and patients as possible," David Spetzler, president and CEO of Caris, said in a statement. "Building on the success of our Epic Genomics Module integration, ORA will further enhance patient access to critical molecular results they need to fight, and hopefully beat, cancer."

Alan Hutchison, VP of population health at Epic, said, "We are excited for this enhanced partnership with Caris to further increase health access and care, and the opportunity to help deliver precision medicine to a greater number of communities."

Twitter:@MikeMiliardHITNEmail the writer:mike.miliard@himssmedia.comHealthcare IT News is a HIMSS publication.

Original post:

Epic, Caris Life Sciences working together on molecular testing integration - Healthcare IT News

One Health Approach Is Necessary to Address Rising Environmental Causes of Childhood Cancers – Newswise

Posted on July 8, 2022 by Danzig

Newswise A multi-disciplinary, One Health approach to cancer research is necessary to guide society in reduction of toxic substances, as well as regulation of chemical impacts on the environment and public health, according to an editorial published recently in Issue II of Annals of Research in Oncology.

This medical-scientific journal is published by Editor in Chief Professor Antonio Giordano, M.D., Ph.D., Director and Founder of Sbarro Institute for Cancer Research and Molecular Medicine, and the Sbarro Health Research Organization (SHRO), at Temple University. The editorial by Prof. Philip Landrigan, Director of the Global Public Health Programme, highlights the relationship between environmental issues and childhood cancer cases, which have been growing rapidly over the past 50 years.

Landrigan's editorial moves towards the new scientific paradigm known as One Health, by which is meant the indissoluble intertwining of three factors: human health, animal health and environmental health as interconnected and dependent on each other.

In particular, Landrigan emphasises the link between environment and cancer in paediatric subjects, underlining the lack of scientific models that consider the use of chemicals with undesirable effects on human health, which are not carefully studied, and the consequent increase in oncological cases in paediatrics. In fact, there is evidence that environmental exposure, in particular to manufactured chemicals, are a major cause of childhood cancer. The National Cancer Institute currently directs about 1% of its funding towards research into environmental causes of paediatric cancers.

Landrigan's hope is to identify new scientific models based on epidemiological and toxicological studies to address the rising incidence of childhood cancer, a major challenge for society and the cancer and public health communities.

Excerpt from:

One Health Approach Is Necessary to Address Rising Environmental Causes of Childhood Cancers - Newswise

Promising topline results for intralymphatic Diamyd in patients with LADA – PR Newswire

Posted on July 8, 2022 by Danzig

STOCKHOLM, July 7, 2022 /PRNewswire/ --The primary endpoints of safety and tolerability were met in the open-label investigator-initiated Phase II clinical trial GADinLADA, in which the diabetes vaccine Diamydwas administered directly into the lymph node of 14 patients aged 30 to 70 years with the autoimmune form of diabetes called LADA (Latent Autoimmune Diabetes in Adults). Analyses also showed a positive immunological response to the treatment and the clinical course appears promising with all individuals remaining insulin-independent 12 months after treatment.

"These results are very encouraging and the next step is together with collaborators and authorities evaluate the regulatory requirements to get the diabetes vaccine Diamyd approved as a disease-modifying therapy in individuals diagnosed with LADA", says Ulf Hannelius, CEO of Diamyd Medical.

All patients in the trial were followed for twelve months after their first injection. The topline results showed that the safety was good with no treatment-related severe adverse events. The treatment was well tolerated by the trial participants, all of whom completed the study with no drop-outs. The immunological analyses showed a similar response to the treatment as has been shown in previous trials in individuals with recent-onset type 1 diabetes, with a clear GAD-specific immune response evident in both circulating antibodies and cell-based reactions.

The clinical course appears positive with all 14 individuals remaining insulin-independent after 12 months of follow-up. The endogenous insulin production, measured as mixed-meal stimulated C-peptide, declined on average only 10% over 12 months.

"The GADinLADA trial has been successful, and treatment with three intralymphatic injections of Diamyd has been well received by the LADA patients," says PhD Ingrid K Hals, Sponsor's representative of the trial. "We will present the results from this trial at the upcoming international Europen Association for the Study of Diabetes (EASD) conference in Stockholm in September and we look forward to evaluating together with Diamyd Medical the next steps to make this important treatment available for individuals diagnosed with LADA."

Of the 14 LADA patients included in the trial, half carry the HLA haplotype DR3-DQ2 that is associated with a positive clinical response to Diamyd treatment in individuals recently diagnosed with type 1 diabetes. For the 7 individuals carrying HLA DR3-DQ2, endogenous insulin production (stimulated C-peptide) decreased on average by 8 % over the 12 month study period, while in the 7 individuals not carrying HLA DR3-DQ2, it declined by 13 %. GAD-stimulated cell proliferation showed a decrease in proliferation between 5 and 12 months for the HLA-DR3-DQ2 group while a comparable decrease was not observed for the group negative for HLA DR3-DQ2, reflecting the patterns seen in recent-onset type 1 diabetes.

The results will be presented at the upcoming EASD conference to be held in Stockholm on September 19-23, 2022. The accepted abstract is entitled "Early effects of treatment with intralymphatic administration of rhGAD65 in LADA appear similar to those observed in type 1 diabetes", and will be presented as an oral abstract on September 20, 2022, as part of the session "OP 10 Beta cells: protecting what is precious".

About the GADinLADA trialThe main aim of the trial was to evaluate the safety of three intralymphatic injections of Diamyd in patients with LADA (Latent Autoimmune Diabetes in Adults). The patients were recruited in Norway at the Norwegian University of Science and Technology (NTNU), Dept. of Clinical and Molecular Medicine, in Trondheim, in collaboration with St. Olavs Hospital, University Hospital in Trondheim, and in Sweden at the Center for Diabetes, Akademiskt specialistcentrum, an academic specialist unit run in collaboration between Stockholm County's healthcare area, Karolinska Institutet and Karolinska University Hospital. The patients included in the trial were between 30 and 70 years old, diagnosed with LADA within the last 18 months and were not yet on insulin therapy. The Sponsor of the trial has been the Norwegian University of Science and Technology with Ingrid K Hals, PhD, as Sponsor's representative. Diamyd Medical has contributed with study drugs, expertise and some financial support for immunological analyses and determination of HLA haplotypes.

About LADALatent Autoimmune Diabetes in Adults represents close to 10% of patients diagnosed with type 2 diabetes. LADA is characterized by an ongoing autoimmune destruction of the insulin-producing beta cells, a process similar to that of type 1 diabetes, but slower. Although research categorizes LADA as autoimmune diabetes, the disease is still in most cases treated according to the guidelines for type 2 diabetes. LADA patients are usually not insulin dependent at diagnosis, but for most patients, insulin therapy is required within a few years of diagnosis.

About Diamyd MedicalDiamyd Medical develops precision medicine therapies for Type 1 Diabetes. The diabetes vaccine Diamyd is an antigen-specific immunotherapy for the preservation of endogenous insulin production. Significant results have been shown in a large genetically predefined patient group in a large-scale meta-analysis as well as in the Company's European Phase IIb trial DIAGNODE-2, where the diabetes vaccine was administered directly into a lymph node in children and young adults with recently diagnosed type 1 diabetes. DIAGNODE-3, a confirmatory Phase III trial is on-going. A vaccine manufacturing facility is being set up in Ume for the manufacture of recombinant GAD65, the active ingredient in the therapeutic diabetes vaccine Diamyd. Diamyd Medical also develops the GABA-based investigational drug Remygen as a therapy for regeneration of endogenous insulin production and to improve hormonal response to hypoglycaemia. An investigator-initiated Remygen trial in individuals living with type 1 diabetes for more than five years is ongoing at Uppsala University Hospital. Diamyd Medical is one of the major shareholders in the stem cell company NextCell Pharma AB as well as in the artificial intelligence company MainlyAI AB.

Diamyd Medical's B-share is traded on Nasdaq First North Growth Market under the ticker DMYD B. FNCA Sweden AB is the Company's Certified Adviser; phone: +46 8-528 00 399, e-mail: [emailprotected]

For further information, please contact:Ulf Hannelius, President and CEOPhone: +46 736 35 42 41E-mail: [emailprotected]

This information was brought to you by Cision http://news.cision.com

https://news.cision.com/diamyd-medical-ab/r/promising-topline-results-for-intralymphatic-diamyd--in-patients-with-lada,c3598517

The following files are available for download:

SOURCE Diamyd Medical AB

Here is the original post:

Promising topline results for intralymphatic Diamyd in patients with LADA - PR Newswire

New Study shows Urolithin A (Mitopure) Improves Mitochondrial Health, Reduces Joint Cartilage Damage and Alleviates Pain in Osteoarthritis – Business…

Posted on July 8, 2022 by Danzig

Lausanne, Switzerland & San Francisco, United States:

New research by scientists at Amazentis and Scripps Research indicates Urolithin A shows promise for improving mobility with beneficial effects on structural damage in joints, published in Aging Cell

Tests in cells from healthy donors and from osteoarthritis (OA) human patients, and in the joints of OA mice, show improvements associated with increased mitochondrial health

Amazentis, a spin-off of the Swiss Federal Institute of Technology (EPFL) pioneering scientific breakthroughs in cellular health and nutrition, announced today that the peer-reviewed journal Aging Cell published new pre-clinical results showing the joint health benefits of gut microbiome postbiotic Urolithin A (UA). This is the first time a compound has been shown to improve mitochondrial health in an experimental model of osteoarthritis (OA).

This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20220707005266/en/

(Photo: Amazentis)

This study showed that treatment with Amazentis proprietary Urolithin A, Mitopure, significantly improved mitochondrial health in human cartilage cells taken from both healthy and OA knee joints. And it showed that supplementation with Mitopure for eight weeks protected against osteoarthritis disease progression in an experimental model.

These findings highlight Mitopures benefits for joint and mitochondrial health. Mitopure works by supporting the cells ability to renew their powerplants, the mitochondria, during the aging process. This change is associated with age-related problems in various tissues, including osteoarthritis.

Previous research has shown Mitopure can improve mitochondrial health and muscle function in both older and middle-aged human populations. This new paper extends these benefits to cells in key joints such as the knee. Osteoarthritis is the most common age-related joint disorder, characterized by degradation of cartilage and other tissues, severe pain, and impaired mobility.

There are currently no effective solutions to treat osteoarthritis, a condition that is painful and limits the mobility of hundreds of millions of older people around the world. We tested Urolithin A in preclinical models of osteoarthritis and showed it has potential to both reduce inflammation and improve mitochondrial health, suggesting it may be a promising solution to support joint health and quality of life during aging, says Martin Lotz MD, lead author on the paper and Professor of Molecular Medicine at Scripps Research in California, USA.

This study is important and exciting as it shows, for the first time, that Urolithin A can increase mitochondrial health in living joint tissue, says Davide DAmico, first author on the paper and R&D Group Leader with Amazentis. It highlights the important role of mitophagy in maintaining healthy functioning joints throughout life.

In this study, Mitopure showed two key beneficial effects on cartilage cells from both healthy donors and OA patients:

The second part of the study focused on the effect of supplementing Mitopure for 2 months on an experimental pre-clinical model of osteoarthritis. This model mimics the same symptoms experienced by people suffering from osteoarthritis, i.e. progressive cartilage damage, increased pain and inflammation.

"It was great to collaborate with Scripps Research to expand the body of evidence on the health applications of Urolithin A into joint health. Its exciting to see a compound and mechanism of action that is benefiting both muscle and joints. We remain committed to delivering products that are clinically proven to have a meaningful impact on peoples health says Chris Rinsch, CEO and co-founder of Amazentis.

The new results are significant because they add to growing evidence of the benefits of Mitopure on age-related conditions. Recent studies showed that Mitopure can improve mitochondrial health and counteract age-related muscle function decline in both healthy elderly and middle-aged overweight subjects. Together, the latest research supports a combined beneficial action of Urolithin A in both muscle and joints.

Doi: 10.1111/acel.13662

About Amazentis Amazentis is an innovative life sciences company employing todays leading research and clinical science to develop the next generation of products targeting mitochondrial health for advanced nutrition. Amazentis has previously published its research on Mitopure Urolithin A in top peer reviewed scientific journals including Nature Medicine (doi:10.1038/nm.4132), Nature Metabolism (doi: 10.1038/s42255-019-0073-4), JAMA Network Open (doi:10.1001/jamanetworkopen.2021.44279), Cell Reports Medicine(Doi: 10.1016/j.xcrm.2022.100633) and European Journal of Clinical Nutrition (https://doi.org/10.1038/s41430-021-00950-1). The company has a global strategic partnership with Nestl Health Science to expand the health applications of Mitopure linked to mitochondrial and cellular health. For more information on Amazentis, please visit http://www.amazentis.com.

About Mitopure Mitopure is a highly pure form of Urolithin A; a bioactive dietary metabolite that is produced by gut bacteria after eating certain foods, such as the pomegranate, though it is difficult for most people to get enough of this specialized nutrient from food alone. Mitopure has been shown to improve mitochondrial function by stimulating mitophagy, a process by which aging and damaged mitochondria are cleared from the cell, making way for healthy mitochondria to grow. Mitopure has been favorably reviewed by the U.S. Food and Drug Administration (FDA) and deemed safe following a GRAS (generally recognized as safe) filing. Mitopure has been extensively evaluated pre-clinically and clinically to support its use in humans for nutritional supplementation. For more information, please visit http://www.mitopure.com.

About Timeline Timeline is brought to you by the inventors of Mitopure. This novel, science-first nutrition brand was developed by Amazentis on the belief that uncompromising research can unlock a new class of clinically validated nutritional products to optimize cellular health. For more information, please visit http://www.timelinenutrition.com.

The NRC HL Holmes Award supports the development of technology to target and treat basal-like breast cancer – National Research Council Canada -…

Posted on July 8, 2022 by Danzig

The 2021 H.L. Holmes Award was presented to Dr. Khalid Al-Zahrani for his novel advancements in breast cancer research. In developing a never-before-seen method, he is able to screen for specific cancer driving genes and has validated his research with promising results.

Over two years, the $180,000 award will support Dr. Al-Zahrani in the development of a gene system to identify the cause of basal-like breast cancer (BLBC). As BLBC disproportionally affects younger, premenopausal women and has a relatively poor clinical prognosis, his research will expand our knowledge of this aggressive cancer subtype which could greatly improve existing treatment methods.

Dr. Al-Zahrani will continue to work with Mount Sinai's Lunenfeld-Tanenbaum Research Institute in Toronto where he has been a post-doctoral research fellow since 2019 in Dr. Daniel Schramek's group, a world-renowned expert in genetic models of cancer. Dr. Al-Zahrani completed his Ph.D. (Philosophy, Cellular and Molecular Medicine) and B.Sc. (Specialization in Biochemistry) at the University of Ottawa and has published over a dozen articles in scientific and medical journals. As a Canadian with roots in Scotland and Saudi Arabia, Dr. Al-Zahrani is excited to develop new medicine that will help people worldwide.

Already, Dr. Al-Zahrani is exploring the uncharted field of BLBC copy number alterations with the development of a novel in vivo CRISPR technology. BLBC copy number alterations are parts of the DNA that are gained or lost that cause tumors to develop from normal cells, and in vivo refers to experiments in whole, living organisms. Using the CRISPR system, researchers can edit genes by activating or deactivating specific parts of genetic code, which allows for precise manipulation of DNA. Dr. Al-Zahrani is a pioneer in the field of BLBC genetics as he aims to understand the underlying mechanisms that drive cancer cells. His findings may uncover new approaches in the way we provide treatment.

Over two years, Dr. Al-Zahrani generated 14 different gene targeting systems in hopes of finding an all-in-one solution to target and screen specific cancer cells. He developed a technology termed KOALA (Knock-Out and Activation Linked Assay) which, when paired with CRISPR, can pick out certain parts of genetic code and trigger precise activation or deactivation. Overcoming numerous roadblocks, he finally achieved a system sufficient for use in mouse specimens. His method will allow for screening of specific BLBC genes and may ultimately identify parts of genetic code that trigger tumor growth. Importantly, KOALA allows for the rapid screening of thousands of cancer-causing genes in a single experiment, whereas conventional techniques screen a single potential cancer-causing gene at a time. The efficiency of his system is validated by discovering several new potential targets for treating BLBC. This is a pivotal step in understanding breast cancer as it greatly improves upon existing methodologies by saving both time and money in the identification of important cancer-driving genes. In combination with conventional tumor-suppressing gene therapy, identification of specific cancer-causing genes allows for highly targeted therapeutic approaches.

While mouse models are suitable for initial experiments, Dr. Al-Zahrani will carefully evaluate further findings in human patient samples. His innovative progress has the potential to uncover new effective cancer treatments and improve the clinical prognosis of basal-like breast cancer.

Original post:

The NRC HL Holmes Award supports the development of technology to target and treat basal-like breast cancer - National Research Council Canada -...

Sri Lanka : WHO provides technical support to the study on investigating seroprevalence of SARS-CoV-2 and dengue infections in Sri Lankan children -…

Posted on July 8, 2022 by Danzig

* WHO provides technical support to the study on investigating seroprevalence of SARS-CoV-2 and dengue infections in Sri Lankan childrenFri, Jul 8, 2022, 12:23 pm SL Time, ColomboPage News Desk, Sri Lanka.

July 08, Colombo: Sri Lanka too experienced a rapid rise in number of cases and deaths, with the community spread of the Delta variant of the SARS-CoV -2 virus. However, deaths were predominantly seen among adults, with children rarely developing severe disease, as observed in other countries.

Sri Lanka experienced two massive COVID-19 outbreaks due to the Alpha and Delta variants of the SARS-CoV -2 virus, resulting in a large number of individuals being infected in the community. It was estimated that surveillance of SARS-CoV-2 with the Real-time polymerase chain reaction (RT-PCR) testing alone may underestimate the true prevalence of the disease by tenfold. Therefore, conducting a seroprevalence study remained an option for Sri Lanka to determine prevalence of SARS CoV-2 specific antibodies due to infection or vaccines in the country.

Seroprevalence studies help understand the true extent of an outbreak and provide valuable insights in to efforts that help project the trend of future outbreaks, and their transmission dynamics. However, in Sri Lanka, a majority of infections was reported in adults, most of whom experienced more severe and symptomatic infections. On the other hand, true infection rates among children in the country were not clearly known. One of the reasons for this could be limited PCR testing in children, largely because they do not show symptoms following infection with SARS-CoV-2 virus. Also, infection rates could be very different across districts, based on the intensity of transmission reported in different geographical regions.

Considering the above, the Allergy Immunology and Cell Biology Unit, Department of Immunology and Molecular Medicine, University of Sri Jayewardenepura and the Ministry of Health supported by WHO Country Office for Sri Lanka planned a study on seroprevalence of SARS-CoV-2 infections and dengue infections in Sri Lankan children.

In order to submit the study protocol to WHOs Ethical Review Committee, a joint review of study protocols was undertaken by the Unity trial desk of WHO Headquarters, the SEA Regional Office and the WHO country office for Sri Lanka. After revising the study protocol based on WHO recommendations, investigators submitted the finalized protocol to the Regional Review Committee.

The proposed study will help Sri Lanka determine the proportion of children who have been infected with COVID-19 and also with dengue, by studying the presence of antibodies to these viruses in children of different age groups. Additionally, it will determine genetic associations that predispose children to severe disease of dengue. Further, the study will provide information that will help understand how COVID-19 and dengue have spread geographically in the Sri Lankan population.

The seroprevalence in this study will be determined by biological assays, which are both qualitative and quantitative (ELISA, Luminex). The patient data will be collected on clinical features, clinical disease severity and complications.

The findings of this investigation will be used to inform public health response to COVID-19. Specifically, it can provide estimates of otherwise unrecognized SARS-CoV-2 infection in the population, as well as likely susceptibility of the population to further epidemic peaks. The findings may also supplement other supportive evidence used to inform decision-making about vaccine prioritization for target groups, based on demonstrated susceptibility by age groups.

Read the original here:

Sri Lanka : WHO provides technical support to the study on investigating seroprevalence of SARS-CoV-2 and dengue infections in Sri Lankan children -...

Select Page ::