OSDD Experts Voices – OSDD in a new phase Dr Balganesh Head OSDD UNIT – Video

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OSDD Experts Voices - OSDD in a new phase Dr Balganesh Head OSDD UNIT
OSDD is a CSIR led team India Consortium with global partnership with a vision to provide affordable healthcare to the developing world by providing a global platform where the best minds can collaborate collectively endeavor to solve the complex problems associated with discovering novel therapies for neglected tropical diseases like Malaria, Tuberculosis, Leshmaniasis, etc.OSDD is a translational platform for drug discovery, bringing together informaticians, wet lab scientists, contract research organizations, clinicians, hospitals and others who are willing to adhere to the affordable healthcare philosophy. It is a concept to collaboratively aggregate the biological, genetic and chemical information available to scientists in order to use it to hasten the discovery of drugs. This will provide a unique opportunity for scientists, doctors, technocrats, students and others with diverse expertise to work for a common cause. The success of Open Source models in Information Technology (For eg, Web Technology, The Linux Operating System) and Biotechnology (For eg, Human Genome Sequencing) sectors highlights the urgent need to initiate a similar model in healthcare, ie, an Open Source model for Drug Discovery. Council of Scientific and Industrial Research (www.csir.res.in) India is one of the largest publicly funded research organizations in the world. CSIR has played a key role in the development of industry in India by providing them with technologies. In particular, it ...From:osddvoicesViews:2 0ratingsTime:07:49More inScience Technology

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OSDD Experts Voices - OSDD in a new phase Dr Balganesh Head OSDD UNIT - Video

Episode 6. A Milestone in New Medicines – Video

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Episode 6. A Milestone in New Medicines
PART 1 #65306;TaiMed Biologics -- A New Weapon in the Fight Against AIDS PART 2 #65306;TTY Biopharm -- Relieves the Burden on Hemophiliacs PART 3 #65306;Optimer Biotechnology -- Using Sugar Molecules to Create Cancer VaccineFrom:ccleestagViews:0 0ratingsTime:25:20More inScience Technology

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Engineering of plants with improved properties as biofuels feedstocks by vessel-specific complementation of xylan biosynthesis mutants

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Background:
Cost-efficient generation of second-generation biofuels requires plant biomass that can easily be degraded into sugars and further fermented into fuels. However, lignocellulosic biomass is inherently recalcitrant toward deconstruction technologies due to the abundant lignin and cross-linked hemicelluloses. Furthermore, lignocellulosic biomass has a high content of pentoses, which are more difficult to ferment into fuels than hexoses. Engineered plants with decreased amounts of xylan in their secondary walls have the potential to render plant biomass a more desirable feedstock for biofuel production.
Results:
Xylan is the major non-cellulosic polysaccharide in secondary cell walls, and the xylan deficient irregular xylem (irx) mutants irx7, irx8 and irx9 exhibit severe dwarf growth phenotypes. The main reason for the growth phenotype appears to be xylem vessel collapse and the resulting impaired transport of water and nutrients. We developed a xylan-engineering approach to reintroduce xylan biosynthesis specifically into the xylem vessels in the Arabidopsis irx7, irx8 and irx9 mutant backgrounds by driving the expression of the respective glycosyltransferases with the vessel-specific promoters of the VND6 and VND7 transcription factor genes. The growth phenotype, stem breaking strength, and irx morphology was recovered to varying degrees. Some of the plants even exhibited increased stem strength compared to the wild type. We obtained Arabidopsis plants with up to 23% reduction in xylose levels and 18% reduction in lignin content compared to wild-type plants, while exhibiting wild-type growth patterns and morphology, as well as normal xylem vessels. These plants showed a 42% increase in saccharification yield after hot water pretreatment. The VND7 promoter yielded a more complete complementation of the irx phenotype than the VND6 promoter.
Conclusions:
Spatial and temporal deposition of xylan in the secondary cell wall of Arabidopsis can be manipulated by using the promoter regions of vessel-specific genes to express xylan biosynthetic genes. The expression of xylan specifically in the xylem vessels is sufficient to complement the irx phenotype of xylan deficient mutants, while maintaining low overall amounts of xylan and lignin in the cell wall. This engineering approach has the potential to yield bioenergy crop plants that are more easily deconstructed and fermented into biofuels.Source:
http://www.biotechnologyforbiofuels.com/content/5/1/84

Biotechnology: Things you should know about Gene Therapy

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Introduction

Genetic disorders are becoming common nowadays due to stressful modern lifestyle. Latest technologies are the added values to create many genetic disorders. To overcome the disorders, Gene therapy is a blessing. In order to compensate abnormal genes and make a good gene, genetic material is introduced into cells. In this way, mutated gene will act as a normal gene. Let us see in detail.

Ways to insert the gene

There are indirect ways need to be followed to make a gene to function as if it is inserted directly does not function. Carrier also called as vector is used to deliver the gene. In the place of vectors, virus play the role as they are getting modified and hence people are not affected with new diseases when it is integrated into the chromosome of the human cell.

The vectors need to get injected to specific tissue in the body or outwardly patient’s cell is removed and exposed to the vector. In either of the ways need to be again returned to the patient. Successful treatment makes proper genes and genetic disorders get solved.

Gene therapy for treating cancer

Cancer is the dangerous disease and there are many ways to cure cancer including surgery, chemotherapy, and radiation. But cancerous cells in due course again spread and hence it is a deadly disease. Gene therapy is the best way discovered nowadays for treating cancer.
Let us see the basic fundamentals of cells. cells include packets of data in genes, created either from DNA or RNA. Sequence is there for DNA and if it is in the order, there will be no problem. But at the same time If there is disorder occurs in portion of the genes either turning or changing the position, cells lost their control and abnormal growth is seen which result in cancerous tumors. It can spread in mouth, breast, lung etc.,

Specialists in Gene therapy analyze the patient’s criticality first and follow the treatment procedures. One way is they replace missing or mutated genes into wholesome genes. Inserting totally new genes for fighting cancer, placing DNA into cancerous cells to undergo chemotherapy and radiation or injecting bad gene to destroy them etc., Mesothelioma type of cancers are not at all responded in formal therapies and hence one need to undergo gene therapy essentially. Need to have consultations with doctors to overcome their deadly disease.

Gene therapy importance

Doctors decide whether gene therapy is suitable by the following approaches. If genetic disorders are from mutations in one or more genes or whether a normal copy of the gene that is available in the patient is enough to fix the problems in the affected cells, then doctors determine that gene therapy will be more helpful rather than going for traditional methods.

Conclusion

Genetic engineering is a vast topic. Latest Science innovations in the field of genetic engineering yields for gene therapy. Doctors and scientists together working to find out whether gene therapy is the best suitable way for treating deadly diseases like cancer and others. Let us salute for the positive force of gene therapy.

 

Source:
http://www.biotechblog.org/entry/biotechnology-gene-therapy/

Biodiscovery and what a fish can see – Video

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Biodiscovery and what a fish can see
Biodiscovery is the science of collecting organic structures from the natural environment. These natural specimens collected from coral reefs and sponges have evolved over millions of years and provide scientists with unimaginable chemical structures that are later made into medical and technological products. For example sunscreens, cures to disease even possibly cures to cancers. This video covers biodiscovery, biotechnology and even how scientists are now able to looking at how fish sense their environment through the perspective of a fish.From:Trevor DominicViews:0 0ratingsTime:04:24More inScience Technology

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Ribbon "lifting" for 100000th cross display at IRRI – Video

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Ribbon "lifting" for 100000th cross display at IRRI
Also see: http://www.youtube.com On 29 November 2012, the community at the International Rice Research Institute (IRRI; irri.org) celebrated the 100000th rice breeding cross, a true milestone in the Institute #39;s 52-year history existence. The parents for the 100000th cross were IR09M105 and NSICRC 214.The objective of this particular cross was to improve eating quality. In this clip, Bas Bouman (left), director of the Global Rice Science Partnership (GRiSP) and Bruce Tolentino, deputy director general for communications and partnerships, "lift" the ribbon at the display showing the mature plants resulting from the cross along with the parents in the background. Glenn Gregorio, senior scientist in Plant Breeding, Genetics, and Biotechnology (PBGB) at IRRI, is the MC wrapped in the ribbon by Dr. Bouman at the conclusion. Special guest at the event was Rizal M. Herrera, who was among the first breeders to make crosses at IRRI in the early 1960s - http - Mr. Herrera arrived at IRRI in 1961 as a research aide and retired 36 years later in 1997 as a senior assistant scientist. Below is his poem-essay about how, in rice breeding, marriage respects no boundaries. Marriage Respects No Boundaries by Rizal M. Herrera IRRI rice breeder, 1961-97 Innocent-looking rice plants also engage in courtship and marriage practices. The rites are simple, devoid of elegant, expensive entourage, and there are no high government officials in flashy cars acting as principal sponsors. The bride, the ...From:irrivideoViews:64 3ratingsTime:02:29More inEducation

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Life Un(Ltd), Charis Thompson, Three Times a Woman- A Gendered Economy of Stem Cell Innovation Pt. 2 – Video

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Life Un(Ltd), Charis Thompson, Three Times a Woman- A Gendered Economy of Stem Cell Innovation Pt. 2
This presentation was part of CSW #39;s Life (Un)Ltd project, and took place on October 24, 2012. Life (UnLtd) is an interdisciplinary project initiated by CSW Associate Director Rachel Lee that engages recent developments in biosciences and biotechnology, foregrounding critical, aesthetic, and ethics-based approaches to what have become global research and marketing industries.From:UCLAViews:6 0ratingsTime:36:53More inEducation

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Life Un(Ltd), Charis Thompson, Three Times a Woman- A Gendered Economy of Stem Cell Innovation Pt. 2 - Video

Life UnLtd, Charis Thompson, Three Times a Woman A Gendered Economy of Stem Cell Innovation Pt 1 – Video

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Life UnLtd, Charis Thompson, Three Times a Woman A Gendered Economy of Stem Cell Innovation Pt 1
This presentation was part of CSW #39;s Life (Un)Ltd project, and took place on October 24, 2012. Life (UnLtd) is an interdisciplinary project initiated by CSW Associate Director Rachel Lee that engages recent developments in biosciences and biotechnology, foregrounding critical, aesthetic, and ethics-based approaches to what have become global research and marketing industries.From:UCLAViews:6 0ratingsTime:27:24More inEducation

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Life UnLtd, Charis Thompson, Three Times a Woman A Gendered Economy of Stem Cell Innovation Pt 1 - Video

2012 Interview with Joe Bouton, Ph.D. – Video

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2012 Interview with Joe Bouton, Ph.D.
After an association that began in the mid-1990s, Dr. Joe Bouton retired from the Samuel Roberts Noble Foundation in December 2012. In late October 2012, Bouton sat for an interview in which he reviewed his time with the Noble Foundation and looked to the future of the Forage Improvement Division and the organization #39;s forage breeding program. During his tenure at the Noble Foundation, Bouton served as a non-resident fellow, acting head of the Forage Biotechnology Group, director of the Forage Improvement Division, senior vice president and senior professor. Before coming to the Noble Foundation as director of the Forage Improvement Division, Bouton had a successful career at the University of Georgia at Athens. His forage breeding work has resulted in the release of many commercialized cultivars that are important to farmers and ranchers in the Southern Great Plains and across the southeastern United States.From:thenoblefoundationViews:9 0ratingsTime:05:30More inEducation

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Passfail.com News: Tuesday Sector Leaders: Music

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Passfail.com News: Tuesday Sector Leaders: Music Electronics Stores, Biotechno...
In trading on Tuesday, music electronics stores shares were relative leaders, up on the day by about 1.7%. Leading the group were shares of Radioshack (RSH), up about 5.1% and shares of Best Buy (BBY) up about 2.4% on the day. Also showing relative strength are biotechnology shares, up on the day by about 1.7% as a group, led by Acadia Pharmaceuticals (ACAD), trading higher by about 138.3% and Peregrine Pharmaceuticals (PPHM), trading higher by about 17.9% on Tuesday. This is Sayoko Murase for Passfail.com, taking you behind the ticker. For Passfail.com, Behind The Ticker (TM) Pass Fail NewsFrom:passfailtvViews:0 0ratingsTime:00:45More inNews Politics

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Mario Ottiglio of IFPMA on WHO R

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Mario Ottiglio of IFPMA on WHO R D financing and treaty negotiations
Interview with Mario Ottiglio, Associate Director, Public Affairs Global Health Policy for the International Federation of Pharmaceutical Manufacturers and Associations (IFPMA). IFPMA is a Geneva based trade organization that represents the research-based pharmaceutical industry, including the biotechnology and vaccine sectors. Mario was interviewed by KEI on November 26, 2012, about the WHO negotiations on a medical R D treaty.From:KEIWashDCViews:4 0ratingsTime:01:48More inScience Technology

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Mario Ottiglio of IFPMA on WHO R

Let’s Play Deus Ex: Human Revolution Ep. 3 – Video

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Let #39;s Play Deus Ex: Human Revolution Ep. 3
(Mature)(Casual)(Commentary) Cyberpunk with me. The game is set in 2027, 25 years before the first game in the series, at a time when multinational corporations have grown in power beyond the control of national governments. The game follows Adam Jensen, the newly hired security director at Sarif Industries, a growing biotechnology firm. After terrorists brutally attack Sarif #39;s Detroit-based headquarters, the mortally wounded Jensen is forced to undergo radical life-saving surgeries that replace large areas of his body with advanced prostheses. Returning to work, he becomes embroiled in the global politics of the human enhancement movement in the search for those responsible for the attack. A central theme to the game is the rise of corporations in globalization, espionage, human survival, poverty and the ethics of advancing humans with artificial replacements for body parts. playlist - http://www.youtube.comFrom:AngryjollyViews:0 0ratingsTime:22:17More inGaming

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Let's Play Deus Ex: Human Revolution Ep. 3 - Video

ECOLife Expo 2012: Jing Liu (Lund University) talks about AMPTS and biogas power – Video

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ECOLife Expo 2012: Jing Liu (Lund University) talks about AMPTS and biogas power
ECOLife Expo 2012: Jing Liu (Lund University) talks about AMPTS and biogas power Jing Liu, Ph.D, Associate Professor at the Department of Biotechnology of Lund University, talks about the present of biogas power, introducing AMPTS.From:nicklandtubeViews:0 1ratingsTime:02:03More inScience Technology

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ECOLife Expo 2012: Jing Liu (Lund University) talks about AMPTS and biogas power - Video

NCSU MB 351 Presentation: Food Spoilage! – Video

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NCSU MB 351 Presentation: Food Spoilage!
References: Alfaro, Danilo. "Food Poisoning and Food Spoilage." Culinary Arts. About.com, nd Web. 19 Sept. 2012. culinaryarts.about.com Bailey, Regina. "Bacteria and Food Poisoning." Biology. About.com, nd Web. 19 Sept. 2012. biology.about.com Blackburn, Clive De W, ed. Food Spoilage Microorganisms. Woodhead Publishing, 2006. Knovel. Web. 19 Sept. 2012. http://www.knovel.com Edublogs.org. "Beano Lab." Brebeuf Jesuit Biotechnology, 2012. Web. 30 Oct. 2012. bjpsbiotech.edublogs.org Eye Of Science. "Bacillus Coagulans, SEM." Science Photo Library. Np, nd Web. 30 Oct. 2012. http://www.sciencephoto.com Fischer, Peter. "Molding Bread as a Natural Clock." The Age Of The Earth And The Formation Of The Universe. Timothy H. Heaton, 2005. Web. 30 Oct. 2012. orgs.usd.edu "Food Contamination and Spoilage." Hygiene And Environmental Health HEAT Module. LabSpace, nd Web. 19 Sept. 2012. labspace.open.ac.uk "Food Spoilage and Additives." Biotopics.co.uk, nd Web. 6 Oct. 2012. http://www.biotopics.co.uk "Hardychrom Candida." Hardy Diagnostics. Hugo: Hardy User Group Observer, 1996. Web. 30 Oct. 2012. catalog.hardydiagnostics.com "Kenya Could Save Millions of Shillings If It Can Make Use of a Fungus Which Reduces Aflatoxins in Cereal Crops."Organic Farmer Magazine. The Organic Farmer, Sept. 2010. Web. http://www.organicfarmermagazine.org Mouldy Foods, Cheese, Bread, and Fruit." Science Photo Library. Science Photo, nd Web. 30 http://www.sciencephoto.com "Preservation of Foods." Army Medical. Integrated Publishing, nd Web. 19 ...From:Katherine BarefootViews:0 0ratingsTime:09:40More inEducation

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NCSU MB 351 Presentation: Food Spoilage! - Video

Deus Ex: Human Revolution – Gameplay [First mission] – Video

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Deus Ex: Human Revolution - Gameplay [First mission]
Deus Ex: Human Revolution is a cyberpunk-themed action role-playing video game developed by Eidos Montreal and published by Square Enix, which also produced the game #39;s CGI sequences. Released in August 2011, it is the third game in the Deus Ex series, and a prequel to the original game released in 2000.[13] The Mac OS X version of the game, an "Ultimate Edition" which also contains The Missing Link downloadable content, is published by Feral Interactive and was released on April 26, 2012.[3] The game is set in 2027, 25 years before the first game in the series, at a time when multinational corporations have grown in power beyond the control of national governments. The game follows Adam Jensen, the newly hired security director at Sarif Industries, a growing biotechnology firm. After terrorists brutally attack Sarif #39;s Detroit-based headquarters, the mortally wounded Jensen is forced to undergo radical life-saving surgeries that replace large areas of his body with advanced prostheses. Returning to work, he becomes embroiled in the global politics of the human enhancement movement in the search for those responsible for the attack. A central theme to the game is the rise of corporations in globalization, espionage, human survival, poverty and the ethics of advancing humans with artificial replacements for body parts. Human Revolution received critical acclaim upon its release, with many reviewers praising the open-ended nature of the game and the weight of social ...From:TheManCowBearViews:1 0ratingsTime:34:43More inGaming

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Deus Ex: Human Revolution - Gameplay [First mission] - Video

Therapeutic Uses of Disaccharides presentation – Video

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Therapeutic Uses of Disaccharides presentation
A presentation in Therapeutic Uses of Disaccharides presented by a team of Veterinary Medicine second year students, Cairo University (2012-2013). Narrated by Salma Waheed Abdelhaleem. References: Wikipedia, McGraw Hill, hartONline, designidentity, wise, Howard Hughes medical institute, Harvard School of Public Health, BBC news, world health organization, edentvproject, Pearson education Inc, Medicomdigital, Epinex diagnostics Inc, discovery health channel, Your Practice Online, 3D Medical Animation Library, Dr. RUFUS #39; Medical website, Ucyclyd Pharma, Mechanisms in Medicine, visiblebody, MAYO Clinic, Cancer treatment centers of America, National Center for Biotechnology Information (NCBI), National Cancer InstituteFrom:SalmaWaheedViews:1 0ratingsTime:28:02More inEducation

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Therapeutic Uses of Disaccharides presentation - Video

Extracting DNA – Video

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Extracting DNA
Get the best offer here redirect.viglink.com?key=f341fd9454fc162be8b38d504acbd4e1 out=http%3A%2F%2Fwww%2Eamazon%2Ecom%2Fdp%2FB005CIRCL0 Product Description Extracting DNA DNA has often been called "the building block of life". Therefore, the extraction of this key biological material, which is the first step in its analysis and manipulation, is of primary importance to the field of biotechnology. Your students will use a simple and quick method to isolate DNA and observe its physical characteristics using a variety of sources. Grades 7-10.From:Zelda PointerViews:0 0ratingsTime:00:56More inSports

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Extracting DNA - Video

Reaction wood — a key cause of variation in cell wall recalcitrance in willow

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Background:
The recalcitrance of lignocellulosic cell wall biomass to deconstruction varies greatly in angiosperms, yet the source of this variation remains unclear. Here, in eight genotypes of short rotation coppice willow (Salix sp.) variability of the reaction wood (RW) response and the impact of this variation on cell wall recalcitrance to enzymatic saccharification was considered.
Results:
A pot trial was designed to test if the 'RW response' varies between willow genotypes and contributes to the differences observed in cell wall recalcitrance to enzymatic saccharification in field-grown trees. Biomass composition was measured via wet chemistry and used with glucose release yields from enzymatic saccharification to determine cell wall recalcitrance. The levels of glucose release found for pot-grown control trees showed no significant correlation with glucose release from mature field-grown trees. However, when a RW phenotype was induced in pot-grown trees, glucose release was strongly correlated with that for mature field-grown trees. Field studies revealed a 5-fold increase in glucose release from a genotype grown at a site exposed to high wind speeds (a potentially high RW inducing environment) when compared with the same genotype grown at a more sheltered site.
Conclusions:
Our findings provide evidence for a new concept concerning variation in the recalcitrance to enzymatic hydrolysis of the stem biomass of different, field-grown willow genotypes (and potentially other angiosperms). Specifically, that genotypic differences in the ability to produce a response to RW inducing conditions (a 'RW response') indicate that this RW response is a primary determinant of the variation observed in cell wall glucan accessibility. The identification of the importance of this RW response trait in willows, is likely to be valuable in selective breeding strategies in willow (and other angiosperm) biofuel crops and, with further work to dissect the nature of RW variation, could provide novel targets for genetic modification for improved biofuel feedstocks.Source:
http://www.biotechnologyforbiofuels.com/content/5/1/83

Paques Brasil officially opened by Princess Máxima – Video

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Paques Brasil officially opened by Princess Máxima
On the 21st of November 2012, Her Royal Highness Princess Máxima of the Netherlands inaugurated Paques Brasil Sistemas para Tratamento de Efluentes Ltda in Piracicaba, Brazil. Princess Máxima performed the official opening ceremony in the presence of the Minister for Foreign Trade and Development Cooperation, Ms. Lilianne Ploumen and the Dutch ambassador in Brazil, Mr. Kees Rade. Afterwards, the Princess was given a tour in the new manufacturing facilities and got informed about the Paques biological treatment technologies for wastewater and gas. The Prince of Orange and Princess Máxima are visiting Brazil from 19th to 23rd of November. This visit coincides with the economic mission of the Dutch Ministry of Foreign Affairs, which aims at strengthening economic ties with Brazil, including in the field of Bio-based Economy. The new subsidiary Paques Brasil is the third sales/production site of the Dutch company Paques, which in the last decades has specialized in the purification of water and gas based on biotechnology. With these technologies Paques has proven to be able to help companies and governments to meet one of the greatest challenges of our contemporary society: reducing the water and CO2 footprint and recovering valuable resources from waste (water). Paques #39; technologies are applied in various sectors all over the world.From:PaquesTVViews:0 0ratingsTime:02:03More inScience Technology

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Paques Brasil officially opened by Princess Máxima - Video