List of life sciences – Wikipedia

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The life sciences or biological sciences comprise the branches of science that involve the scientific study of life and organisms such as microorganisms, plants, and animals including human beings.

Life science is one of the two major branches of natural science, the other being physical science, which is concerned with non-living matter.

By definition, biology is the natural science that studies life and living organisms, with the other life sciences being its sub-disciplines.

Some life sciences focus on a specific type of organism. For example, zoology is the study of animals, while botany is the study of plants. Other life sciences focus on aspects common to all or many life forms, such as anatomy and genetics. Some focus on the micro scale (e.g. molecular biology, biochemistry) other on larger scales (e.g. cytology, immunology, ethology, ecology). Another major, branch of life sciences involves understanding the mind neuroscience.

Life sciences discoveries are helpful in improving the quality and standard of life, and have applications in health, agriculture, medicine, and the pharmaceutical and food science industries.

Biology burst and eclectic field, composed of many branches and sub-disciplines. However, despite the complexity and the broad scope of the science, there are certain general and unifying concepts within it that govern all study and research, consolidating it into a single, coherent field. Here are some of biology's major branches:

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Interpace to Present at the American College of Gastroenterology Conference – Yahoo Finance

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Interpace hosts 2nd Annual Fellow Programs

PARSIPPANY, NJ, Oct. 24, 2019 (GLOBE NEWSWIRE) -- Interpace (IDXG) announced today that it will be presenting new data on the performance of its molecular thyroid and GI products at an industry known scientific international meeting. The American College of Gastroenterology annual meeting is held on October 27-30 in San Antonio, Texas and is one of the largest gatherings of gastroenterologists and endoscopists. These are two key targets for Interpaces PancraGEN test for early detection of cancer in indeterminate pancreatic cysts, solid lesions, and biliary structures. The PancraGEN publication entitled Serial molecular testing of pancreatic cyst fluid over time: progression and regression highlights the Companys unique clinical and molecular database of patient results, examining 2,167 patients with pancreatic cysts that underwent multiple PancraGEN tests over time. The results support the high negative predictive value of PancraGEN, showing that the majority of cases (92%) initially found to have low risk PancraGEN results remained low risk at follow-up. The small portion of patients that did progress only progressed to moderate risk levels, where risk most often regressed to low risk over time.

In addition to the poster, Interpace will host its second annual Fellows program. The keynote speakers will be Dr. Tamas Gonda, Columbia University, and Dr. James Farrell, Yale University. Dr.s Gonda and Farrell are going to be discussing their peer-reviewed published work on the utility of DNA analysis in managing patients with pancreatic cysts, describing molecular results of patients who have undergone PancraGEN testing and how those results can be used to impact patient management decisions.

About Interpace

Interpace is a leader in enabling personalized medicine, offering specialized services along the therapeutic value chain from early diagnosis and prognostic planning to targeted therapeutic applications.

Interpaces Diagnostic Business is a fully integrated commercial and bioinformatics business unit that provides clinically useful molecular diagnostic tests, bioinformatics and pathology services for evaluating risk of cancer by leveraging the latest technology in personalized medicine for improved patient diagnosis and management. Interpace has four commercialized molecular tests and one test in a clinical evaluation process (CEP): PancraGEN for the diagnosis and prognosis of pancreatic cancer from pancreatic cysts; ThyGeNEXT for the diagnosis of thyroid cancer from thyroid nodules utilizing a next generation sequencing assay; ThyraMIR for the diagnosis of thyroid cancer from thyroid nodules utilizing a proprietary gene expression assay; and RespriDX that differentiates lung cancer of primary vs. metastatic origin. In addition, BarreGEN for Barretts Esophagus, is currently in a clinical evaluation program whereby we gather information from physicians using BarreGEN to assist us in positioning the product for full launch, partnering and potentially supporting reimbursement with payers.

Interpaces Biopharma Business provides pharmacogenomics testing, genotyping, biorepository and other customized services to the pharmaceutical and biotech industries. The Biopharma Business also advances personalized medicine by partnering with pharmaceutical, academic, and technology leaders to effectively integrate pharmacogenomics into their drug development and clinical trial programs with the goals of delivering safer, more effective drugs to market more quickly, and improving patient care.

For more information, please visit Interpaces website at http://www.interpacediagnostics.com.

Forward-looking Statements

This press release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, Section 21E of the Securities Exchange Act of 1934 and the Private Securities Litigation Reform Act of 1995, relating to the Company's future financial and operating performance. The Company has attempted to identify forward looking statements by terminology including "believes," "estimates," "anticipates," "expects," "plans," "projects," "intends," "potential," "may," "could," "might," "will," "should," "approximately" or other words that convey uncertainty of future events or outcomes to identify these forward-looking statements. These statements are based on current expectations, assumptions and uncertainties involving judgments about, among other things, future economic, competitive and market conditions and future business decisions, all of which are difficult or impossible to predict accurately and many of which are beyond the Company's control. These statements also involve known and unknown risks, uncertainties and other factors that may cause the Company's actual results to be materially different from those expressed or implied by any forward-looking statement. Known and unknown risks, uncertainties and other factors include, but are not limited to the fact that there is no assurance the acquisition of the BioPharma business of Cancer Genetics, Inc. will be successfully integrated with the Company, or that the potential benefits of the acquisition, including future revenues, will be successfully realized. Additionally, all forward-looking statements are subject to the Risk Factors detailed from time to time in the Company's most recent Annual Report on Form 10-K, Current Reports on Form 8-K and Quarterly Reports on Form 10-Q. Because of these and other risks, uncertainties and assumptions, undue reliance should not be placed on these forward-looking statements. In addition, these statements speak only as of the date of this press release and, except as may be required by law, the Company undertakes no obligation to revise or update publicly any forward-looking statements for any reason.

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UW-Madison study links nicotine addiction to genetic variation in … – Madison.com

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Some smokers have more of an urge to light up right after they wake up, and UW-Madison researchers have identified a reason: genetic variation in a substance that breaks down nicotine in the brain.

The finding, by scientists at UW-Madison and Washington University in St. Louis, adds to growing research on genetic links to how much people smoke, how hard it is for them to quit and how likely they are to develop lung cancer.

Most of the attention has focused on genetic variation in enzymes that metabolize nicotine in the liver. Some studies suggest that dozens of genes could influence how addicted people become to smoking.

The new understanding about FMO3, an enzyme that metabolizes nicotine in the brain, could someday allow researchers to tailor tobacco cessation treatments to individual patients or develop new drugs to target the enzyme.

The research clearly suggests that its not just one or two big players here, but that a lot of genes may contribute to these outcomes, said Tim Baker, director of research at UW-Madisons Center for Tobacco Research and Intervention.

Despite a steady decline in smoking in recent years, tobacco remains the leading cause of preventable death, according to the Centers for Disease Control and Prevention.

About 17.3 percent of Wisconsin adults smoked in 2015. Thats down from 20.9 percent in 2011. Still, nearly 800,000 adults and adolescents in the state continue to light up, resulting in about 7,700 deaths a year, according to the state Department of Health Services.

Nationally, 17.5 percent of adults smoked in 2015, and smoking causes 480,000 deaths a year, the CDC says. More than half of American smokers attempt to quit each year, but only 6 percent succeed.

The brain enzyme study, published earlier this year in The Pharmacogenomics Journal, involved 1,558 smokers, most of them in a study at UW-Madison of people who were trying to quit.

Smokers with genes that produce more FMO3, causing nicotine to be broken down more quickly in the brain, were more likely to say they smoke first thing in the morning a key indicator of nicotine dependence.

Even if they have a home smoking ban, they will go out into their porch or to the garage to have their cigarette right away, as soon as they get up, Baker said.

Smokers with certain genetic types of the liver enzymes respond better to nicotine replacement therapy, researchers have found. Its too early to tell if the same might be true for the brain enzyme.

The genetic information could eventually help more smokers quit, but Baker said they shouldnt wait.

Regardless of their genetic status, although some people are at greater risk than others, any kind of smoking is dangerous and they should do whatever they can to quit now, he said.

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April 16: Pharmacogenomics – National Human Genome …

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PharmacogenomicsChoosing the right medication at the right dose for each patient

April 16, 2018

Did you know ... that the sequence of your genome can determine how you respond to certain medications?

Understanding pharmacogenomics, or tailoring a person's medications based on their genome, would not be possible without sequencing the genomes of many people and comparing their responses to medicines.

Oneof the most important uses for DNA sequencing is not to just sequence one human genome - but rather to sequence many human genomes to understand how genomic differences relate to different traits. Some such traits reflect physical characteristics (like eye color), whereas others can be used to help in the clinical care of patients. Scientists in the field of pharmacogenomics study how specific variants in your genome sequence influence your response to medications.

In order for our bodies to use some medicines properly, the cells in our bodies must make a few chemical changes that convert them into an active form, just like we do when we eat food. Then, these active forms of the medicine must get to the right places in the body or inside cells to do the job that we want them to do. If we want to make sure this happens, it makes sense that we would target our bodies' pathways involved in changing the medicine's form or in getting medicines to the right places. For example, you probably know someone who takes an antidepressant. Many of these medicines get to the right places by interacting with a protein called ABCB1,which works like a traffic cop on the outside of your cells.

Given ABCB1's important role in controlling traffic, you might imagine that if someone has a genomic variant that changes the shape or function of their ABCB1 protein, they might have a different response than usual to any number of medicines. We now know that is the case for some antidepressants, as well as other medications like statins for cholesterol and certain chemotherapy medicines. As a result, there are at least 18 pharmacogenomic tests for variants in ABCB1 listed in the NIH's Genetic Test Registry, with suggestions that you be tested for these variants to help determine the correct dose for certain medications.

Video courtesy of Mayo Clinic

Healthcare professionals and researchers are constantly seeking both to optimize medical treatments and to avoid adverse (or negative) reactions to treatments, which are estimated to affect between 7 percentand 14 percentof hospitalized patients. This makes adverse reactions a large cause of added days spent in a hospital, and the fourth leading cause of death in the United States.

One scary example of such an adverse reaction is Stevens-Johnson syndrome (SJS), a severe allergic reaction also called "scalded skin syndrome." It can be caused by infections, but also by very common medications like ibuprofen, anti-seizure medicines, or antibiotics. Patients may go from taking two pain pills to ending up in the hospital burn unit fighting for their lives if SJS progresses to a worse condition called toxic epidermal necrolysis (TEN). TEN is diagnosed when patients have shed at least one-third of the skin off of their bodies. Needless to say, anything we can do to prevent this allergic reaction is vitally important.

In Taiwan, married scientists Wen-Hung Chung (a physician) and Shuen-Iu Hung (an immunologist) noticed that SJS/TEN was much more common in patients taking carbamazepine, used to treat epilepsy and seizures, or allopurinol, used to treat gout. They showed that this was due to genomic variants in the HLA-B gene. Not surprisingly, this gene helps control the immune response. As a result of their work, the country of Thailand has implemented genomic testing before these medications are prescribed. The results of this "pharmacogenomic test" are used to decide whether it is safe to give a specific patient certain medicines, like carbamazepine or allopurinol. Thailand's government even covers the cost of this testing, and the frequency of SJS/TEN has been drastically reduced. We have since learned that different ancestries are associated with different HLA-B genomic variants, so countries may need to take different approaches to monitor which medications are most likely to be linked to SJS/TEN.

Video courtesy of Mayo Clinic

Understanding pharmacogenomics would not be possible without sequencing the genomes of many people and comparing them, and then comparing their response to medicines. But we have also learned that a person's genome sequence is not everything when it comes to medication responses. The human body is a very complicated machine, and the instructions written in our DNA are just part of the process.

There are some cases, as with the breast cancer treatment tamoxifen, where a small study showed that there might be a relationship between someone's response to the medicine and a variant in the CYP2D6 gene. However, this finding did not appear to be true in a larger study that involved many more people. That's why at this time, the U.S. Food and Drug Administration (FDA) labeling for tamoxifen does not recommend CYP2D6 pharmacogenomic testing, but the issue is still being reviewed as more research is conducted.

Another gene in the same CYP family, called CYP2C19, has variations which affect how your body can use clopidogrel (more commonly known as Plavix). This medication is a "blood thinner" which helps prevent blood clots, and thus reduces your risk of strokes or some heart attacks. If your CYP2C19 protein is not working properly due to a mutation in the gene, then you will not be able to process clopidogrel, and you need either a different dose or a different medication. As it turns out, these variants in CYP2C19 are also more common in those with Asian ancestry. Although testing for variants in this gene is also not routinely recommended, you may wish to speak with your healthcare provider about the test if you are given a prescription for clopidogrel, particularly if you have East Asian family members.

As the field of pharmacogenomics develops, more and more clinical trials will test for interactions between our genomes and the medicines we take. If you are interested in participating in such trials, you can search the ClinicalTrials.gov registry and look for ongoing studies with your condition. If you are curious whether any of your medications are known to be associated with pharmacogenomic information, check out the Pharmacogenomics Knowledge Database and speak with your medical care team. And, if you'd like to be part of a national effort along with one million other people that will involve pharmacogenomics research, look into the National Institute of Health's All of Us program.

Posted: April 16, 2018

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Intermountain lab expands precision medicine with …

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Intermountain Precision Genomics Core Laboratory announced today it is expanding RxMatch. The pharmacogenomics service the study of how genes affect a patients response to medication will be made available to all Intermountain Healthcare providers.

The growth of the effort is indicative of how precision medicine programs across the world are taking off like never before, fueled by the adoption of early diagnosis, an increasing number of adverse drug reaction cases, high prevalence of chronic diseaseand advancements in genetic science.

The global precision medicine market is expected to reach $141.7 billion by 2026, according to a recent report by BIS Research.

The Intermountain lab launched RxMatch as an antidepressant panel in September 2017, the RxMatch Comprehensive Panel introduced today expands the gene targets from 36 to 97.

The panel includes opioids, statins, immune-suppressants, antidepressants and many more. Intermountain will integrate the resulting genomic medicine into clinical care while it also manages the information obtained through genomic sequencing, according to Intermountain.

The objective of this project is to provide the most comprehensive and evidence-based information to the physician," David Loughmiller, laboratory manager for Intermountain Precision Genomics, said in a statement. The result, Loughmiller noted, is decreasing the amount of time and money spent to achieve the correct medication.

The results are used to guide proper dosage based on a patients specific DNA genotype, Tom Neuwerth, clinical technology consultant for Intermountain Precision Genomics Lab, added. Small genetic variations impact how a patient metabolizes and responds to drugs. Our test helps ordering providers prescribe the right medication, at the right dose, at the right time.

Patients supply DNA samples using cheek swabs collected by their physicians. Once samples are received, the lab makes comprehensive reports available within a week.

Intermountains announcement comes just three days ahead of the HIMSS Precision Medicine Summit, slated for May 18-19, 2018 in the nations capital.

Twitter: @Bernie_HITNEmail the writer: bernie.monegain@himssmedia.com

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Interpace Diagnostics Issues Update Regarding Announced Contract with BCBS of Massachusetts – GlobeNewswire

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Parsippany, NJ, March 11, 2020 (GLOBE NEWSWIRE) -- Interpace Diagnostics, a subsidiary of Interpace Biosciences (NASDAQ: IDXG) announced today that it has entered into a contract with Blue Cross Blue Shield of Massachusetts. While terms of this Agreement are not disclosed, Interpace is an in-network lab with Blue Cross Blue Shield of Massachusetts for all product lines.

Interpace continues to expand in-network agreements and medical coverage for its services with leading National and Regional health plans, while maintaining Medicare coverage through Novitas Solutions.

According to Jack Stover, CEO of Interpace, This contract with Blue Cross Blue Shield of Massachusetts continues our trend of establishing improved reimbursement through participation as an in-network provider. Im pleased to announce that this is the first contract secured by our new VP of Managed Care and Payer Relations, Jeff Salzman.

AboutThyroid Nodules, ThyGeNEXT and ThyraMIR Testing

According to theAmerican Thyroid Association, approximately 20% of the 525,000 thyroid fine needle aspirations (FNAs) performed on an annual basis in the U.S. are indeterminate for malignancy based on standard cytological evaluation, and thus are candidates for ThyGenX and ThyraMIR.

ThyGenX and ThyraMIR reflex testing yields high predictive value in determining the presence and absence of cancer in thyroid nodules. The combination of both tests can improve risk stratification and surgical decision-making when standard cytopathology does not provide a clear diagnosis for the presence of cancer.

ThyGenX utilizes state-of-the-art next-generation sequencing (NGS) to identify more than 100 genetic alterations associated with papillary and follicular thyroid carcinomas, the two most common forms of thyroid cancer. ThyraMIR is the first microRNA gene expression classifier. MicroRNAs are small, non-coding RNAs that bind to messenger RNA and regulate expression of genes involved in human cancers, including every subtype of thyroid cancer. ThyraMIR measures the expression of 10 microRNAs. Both ThyGenX and ThyraMIR are covered by both Medicare and Commercial insurers.

AboutInterpace Biosciences

Interpace Biosciences is a leader in enabling personalized medicine, offering specialized services along the therapeutic value chain from early diagnosis and prognostic planning to targeted therapeutic applications.

The Interpace Diagnostics division provides clinically useful molecular diagnostic tests, bioinformatics and pathology services for evaluating risk of cancer by leveraging the latest technology in personalized medicine for improved patient diagnosis and management. Interpace has four commercialized molecular tests and one test in a clinical evaluation process (CEP): PancraGEN for the diagnosis and prognosis of pancreatic cancer from pancreatic cysts; ThyGeNEXT for the diagnosis of thyroid cancer from thyroid nodules utilizing a next generation sequencing assay; ThyraMIR for the diagnosis of thyroid cancer from thyroid nodules utilizing a proprietary gene expression assay; and RespriDX that differentiates lung cancer of primary vs. metastatic origin. In addition, BarreGEN for Barretts Esophagus, is currently in a clinical evaluation program whereby we gather information from physicians using BarreGEN to assist us in positioning the product for full launch, partnering and potentially supporting reimbursement with payers.

The Interpace Pharma Solutions division provides pharmacogenomics testing, genotyping, biorepository and other customized services to the pharmaceutical and biotech industries. The Pharma Solutions Business also advances personalized medicine by partnering with pharmaceutical, academic, and technology leaders to effectively integrate pharmacogenomics into their drug development and clinical trial programs with the goals of delivering safer, more effective drugs to market more quickly, and improving patient care.

For more information, please visit Interpace Biosciences website at http://www.interpace.com.

Forward Looking Statements

This press release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, Section 21E of the Securities Exchange Act of 1934 and the Private Securities Litigation Reform Act of 1995, relating to the Company's future financial and operating performance. The Company has attempted to identify forward looking statements by terminology including "believes," "estimates," "anticipates," "expects," "plans," "projects," "intends," "potential," "may," "could," "might," "will," "should," "approximately" or other words that convey uncertainty of future events or outcomes to identify these forward-looking statements. These statements are based on current expectations, assumptions and uncertainties involving judgments about, among other things, future economic, competitive and market conditions and future business decisions, all of which are difficult or impossible to predict accurately and many of which are beyond the Company's control. These statements also involve known and unknown risks, uncertainties and other factors that may cause the Company's actual results to be materially different from those expressed or implied by any forward-looking statement. Additionally, all forward-looking statements are subject to the risk factors detailed from time to time in the Company's filings with the SEC, including without limitation, the Annual Report on Form 10-K and the companys Quarterly Reports filed with the SEC. Because of these and other risks, uncertainties and assumptions, undue reliance should not be placed on these forward-looking statements. In addition, these statements speak only as of the date of this press release and, except as may be required by law, the Company undertakes no obligation to revise or update publicly any forward-looking statements for any reason.

CONTACTS:

Interpace DiagnosticsInvestor Relations:Joe Green(646) 653-7030jgreen@edisongroup.comEdison Group

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Pain Therapeutics Market Forecasts to 2028 – Advances in Pharmacogenomics & Pharmacogenetics Enabling the Development of Personalized Management – P&T…

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DUBLIN, March 13, 2020 /PRNewswire/ -- The "Pain Therapeutics - Drugs, Markets and Companies" report from Jain PharmaBiotech has been added to ResearchAndMarkets.com's offering.

The worldwide analgesic markets were analyzed for the year 2018 and projected to 2028. Calculations are based on the epidemiology of various painful conditions and the development of analgesic drugs and devices. Unfulfilled needs for analgesics are identified and strategies are outlined to develop markets for analgesic drugs. The report is supplemented with 76 tables, 24 figures, and 600 selected references to the literature.

Over 500 companies have been identified to be involved in developing or marketing pain therapeutics and 173 of these are profiled in the report along with 156 collaborations. These are a mix of pharmaceutical companies and biotechnology companies.

The report describes the latest concepts of pathomechanisms of pain as a basis for management and development of new pharmacotherapies for pain. Major segments of the pain market are arthritis, neuropathic pain and cancer pain. Because pain is a subjective sensation, it is difficult to evaluate objectively in clinical trials. Various tools for pain measurement are described, including brain imaging.

Most of the currently used analgesic drugs fall into the categories of opioids and nonsteroidal antiinflammatory drugs such as COX-2 inhibitors. Non-opioid analgesics include ketamine, a N-methyl-D-aspartate receptor antagonist. Adjuvant analgesics include antidepressants and antiepileptic drugs used for the treatment of neuropathic pain. Management of pain is multidisciplinary and includes both pharmacological and non-pharmacological methods such as acupuncture, transcutaneous electrical nerve stimulation and surgery. Various pain syndromes require different approaches in management, for example, the main category of drugs for migraine are triptans such as sumatriptan.

Drug delivery is an important consideration in pain treatment. Controlled release preparations provide a steady delivery of analgesics. Well-known non-injection methods such astransdermal, pulmonary and intranasal application have been used. Topical analgesics and local anesthetics are also available. Devices such as implanted pumps are used for delivery of drugs such as opioids intrathecally (introduction into spinal subarachnoid space by lumbar puncture) in patients with cancer pain.

The wide variety of drugs in development includes opioid receptor ligands, bradykinin antagonists, mPGES-1 inhibitors, glutamate receptor antagonists, substance P and neurokinin receptor antagonists, norepinephrine transporter inhibitors,P2X2 neuron receptor antagonists and nitric oxide-based analgesics. A number of cannabinoids are also in development for pain. Fish-derived tetrodotoxin was initially focused on indication of opiate addiction withdrawal but is found to have an analgesic action as well. Cone shells contain therapeutically useful peptides including the conotoxins, and one such peptide, ziconotide, has been approved. Various cell and gene therapies are also being developed for the management of pain.

Advances in molecular and biological techniques are markedly advancing our undestanding of pain. Understanding the pathophysiology of pain is an important factor in discovery of rational therapies for pain. Advances in pharmacogenomics and pharmacogenetics are enabling the development of personalized approaches to the management of pain.

Key Topics Covered

Executive Summary1. Basic Aspects of Pain2. Assessment of Pain & Analgesics3. Pharmacotherapy of Pain4. Management of Pain5. Drug Delivery for Pain6. Drug Development for Pain7. Safety, Regulatory and Legal Issues of Pain Management8. Pain Markets9. Future of Pain Therapeutics10. Companies Involved in Pain Therapeutics

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Research and Markets also offers Custom Research services providing focused, comprehensive and tailored research.

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Research and Markets Laura Wood, Senior Manager press@researchandmarkets.com

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Pharmacogenomics Market Report Offers A One-Stop Solution To All The Key Players | Dynamic DNA Laboratories, Empire Genomics LLC and Abbott…

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The Pharmacogenomics Market report emphasizes Key players strategic movements including public relations activities, brand expansions, and product releases. It furnishes about Pharmacogenomics industry supply chain, processing techniques, market entry strategies, investment plans, retailers, and the economic impact on the stock exchange. This report also provides information on the Pricing Strategy, Brand Strategy, Target Client of the Pharmacogenomics Market. This report also include some market-related illustrations and presentations, including pie charts, which represent the percentage division of strategies adopted by the major players in the global market.

Competitive Landscape

Global Pharmacogenomics market is highly cleft and the key players have used numerous plans such as new product launches, acquisitions, mergers, collaborations, innovation in products, expansions, agreements, joint ventures, and others to increase their footmarks in this market.

For Better Understanding, Download Free Sample Copy Of Pharmacogenomics Market Report In Just One Single Step At:https://marketresearch.biz/report/pharmacogenomics-market/request-sample

Key companies profiled in Pharmacogenomics Market report are: Empire Genomics LLC, Thermo Fisher Scientific Inc, Hoffmann-La Roche AG, Assurex Health Inc, Illumina Inc, Myriad Genetics Inc, OPKO Health Inc (GeneDx), Dynamic DNA Laboratories, OneOme LLC and Abbott Laboratories

The report further provides the following information:

Comprehensive analysis of the factors, drivers, and restraints impacting the share, size, and overall growth of the market.

Careful segregation of the market into different segments and in-depth research into the individual segments.

An exhaustive study of the regional and competitive aspects influencing the development of the market.

The report offered Segmentation:

Segmentation by technology:

Polymerase Chain ReactionMicroarraySequencingMass SpectrometryElectrophoresisOthersSegmentation by application:

OncologyInfectious diseasesCardiovascular diseasesNeurological diseasesPsychiatryPain managementOthersSegmentation by end user:

Hospitals and clinicsResearch institutionsAcademic institutes

All of the Technology, Application, End User, And Region segments of the global Pharmacogenomics market included in the report are deeply analyzed based on CAGR, market size, and other crucial factors. The segmentation study provided by the report authors could help players and investors to make the right decisions when looking to invest in certain market segments.

Regional Analysis:

Objective of Studies:

1. To provide detailed analysis of the market structure along with forecast of the various segments and sub-segments of the global Pharmacogenomics market.

2. To provide insights about factors affecting the market growth. To analyse the Pharmacogenomics market based on various factors- price analysis, supply chain analysis, Porte five force analysis etc.

3. To provide historical and forecast revenue of the market segments and sub-segments with respect to four main geographies and their countries- North America, Europe, Asia, Latin America and Rest of the World.

4. To provide country level analysis of the market with respect to the current market size and future prospective.

5. To provide country level analysis of the market for segment by application, product type and sub-segments.

6. To provide strategic profiling of key players in the market, comprehensively analysing their core competencies, and drawing a competitive landscape for the market.

7. To track and analyse competitive developments such as strategic alliances, joint ventures, mergers and acquisitions, new product developments, and research and developments in the global Pharmacogenomics market.

Customize Report AndInquiry For The Pharmacogenomics Market Report:https://marketresearch.biz/report/pharmacogenomics-market/#inquiry

Table of Content

1 Pharmacogenomics Market Overview

2 Global Pharmacogenomics Market Competition by Manufacturers

3 Global Pharmacogenomics Production Market Share by Regions

4 Global Pharmacogenomics Consumption by Regions

5 Global Pharmacogenomics Production, Revenue, Price Trend by Type

6 Global Pharmacogenomics Market Analysis by Applications

7 Company Profiles and Key Figures in Pharmacogenomics Business

8 Pharmacogenomics Manufacturing Cost Analysis

9 Marketing Channel, Distributors and Customers

10 Market Dynamics

11 Global Pharmacogenomics Market Forecast

12 Research Findings and Conclusion

13 Methodology and Data Source

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Pharmacogenomics Market In-depth Study on Analysis and Forecast 2020-2027 – Redhill Local Councillors

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Coherent Market Insights proclaims the obtainability of a new statistical data to its repository titled as, Pharmacogenomics market 2020 2027. It covers the wide-ranging aspects of the businesses such as pillars, features, sales strategies, planning models to get better insights for the businesses. Furthermore, it throws light on recent developments and technological platforms, several tools, and methodologies that help to boost the performance of industries.

This Pharmacogenomics Market report profiles major topmost manufactures operating Thermo Fisher Scientific Inc., Abbott Laboratories, F. Hoffmann-La Roche AG, Qiagen N.V., Pacific Biosciences of California, Inc., Diatech Pharmacogenetics Srl and Assurex Health Inc. in terms of analyse various attributes such as Production, Consumption, Revenue, Gross Margin, Cost, Gross, Market Share, CAGR, and Market Influencing Factors of the Pharmacogenomics industry in USA, EU, China, India, Japan and other regions.

Download PDF with Recent all Updates & Trending Key Players with TOC: https://www.coherentmarketinsights.com/insight/request-pdf/1053

On the basis of product type, this report displays the shipments, revenue (Million USD), price, and market share and growth rate of each type.

Pharmacogenomics Market Taxonomy

The Pharmacogenomics Market report is a compilation of first-hand information, qualitative and competitive assessment industry analysts, inputs from industry experts and industry participants across the value chain. The research report market provides an in depth analysis of parent market trends, macro-economic indicators and governing factors along with market attractiveness as per segments. The report also maps the qualitative impact of various market factors on market segments and geographies.

Geographically, this report is segmented into several key regions,with sales, revenue, market share and growth Rate of Pharmacogenomics in these regions, from 2019 to 2027, covering

North America (United States, Canada and Mexico)

Europe (Germany, UK, France, Italy, Russia and Turkey etc.)

Asia-Pacific (China, Japan, Korea, India, Australia, Indonesia, Thailand, Philippines, Malaysia and Vietnam)

South America (Brazil etc.)

Middle East and Africa (Egypt and GCC Countries)

Different sales strategies have been elaborated to get a clear idea for getting global clients rapidly. It helps various industry experts, policymakers, business owners as well as various c level people to make informed decisions in the businesses. It includes the massive data relating to the technological advancements, trending products or services observed in the market. The major key pillars of businesses such as global Pharmacogenomics market are explained in a concise manner and effectively for fueling the progress of the market.

Our Study Report Offers:

Market share analysis for the regional and country level segments.

Pharmacogenomics Market share analysis of the best business players.

Strategic proposal for the new entrants.

Market forecasts for next five years of all the mentioned segments, sub segments and conjointly the regional markets.

Market Opportunities, Trends, Constraints, Threats, Challenges, Drivers, Investment and suggestions.

Strategic steerage in key business segments supported the market estimations.

Competitive landscaping mapping the key common trends.

Company identification with careful methods, financials, and up so far developments.

provide chain trends mapping the foremost recent technological advancements.

The reports conclusion reveals the overall scope of the Global Pharmacogenomics Market in terms of feasibility of investments in the various segments of the market, along with a descriptive passage that outlines the feasibility of new projects that might succeed in the market in the near future.

Queries regarding the report can be addressed to Coherent Market Insights analysts @ https://www.coherentmarketinsights.com/insight/talk-to-analyst/1053

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Coherent Market Insights is a prominent market research and consulting firm offering action-ready syndicated research reports, custom market analysis, consulting services, and competitive analysis through various recommendations related to emerging market trends, technologies, and potential absolute dollar opportunity.

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Pharmacogenomics Market In-depth Study on Analysis and Forecast 2020-2027 - Redhill Local Councillors

Precision Medicine Software Market to Register the Highest Growth Rate by Applications, and Future F – PharmiWeb.com

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Meticulous Research leading global market research company is researching on precision medicine software market titled Precision Medicine Software Market by Delivery Mode (On-Premise, Cloud-Based), Application (Oncology, Pharmacogenomics, rare diseases), End User (Healthcare Providers, Pharmaceutical & Biotechnology Companies), and Geography-Global Forecast to 2025.

Nowadays, rising advances in big data technology applications for accurate disease detection is creating a positive impact on the precision medicine software market over the forecast period. Moreover, the introduction of various software with an improved clinical workflow will likely increase the ability to store a large amount of genetic data to ensure rapid patient recovery. The factors such as growing acceptance of big data analysis and sequencing of gene therapy are expected to drive the growth of the precision software market during the forecast period.

Download Free Sample Copy Of The Report:: https://www.meticulousresearch.com/download-sample-report/cp_id=5011

Key questions answered in the report-

What are the major drivers, restraints, challenges, and opportunities in the precision medicine software market?

Who are the major players in various countries and what share of the market do they hold?

What are the geographical trends and high growth regions/ countries?

Who are the top competitors in this market and what strategies do they employ to gain shares?

What is driving growth and which market segments have the most potential for revenue expansion over the forecast period?

What strategies should new companies looking to enter in this market use to compete effectively?

Who are the major players in the global precision medicine software market and what share of the market do they hold?

What are the local emerging players in the global precision medicine software market and how do they compete with the global players?

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(In case of any queries or customization requirements please connect with our Experts by Clicking Here who will ensure that your requirements are met.)

On-Premise Delivery Mode Dominated the Precision Medicine Software Market in 2018

On the basis of delivery mode, the precision medicine software market is segmented into on-premise and cloud-based delivery model. On-premises commanded the largest share of precision medicine software market in 2018. The large market share of this segment is primarily attributed to the wide range of advantages regarding the use of on-premise delivery model. However, cloud-based delivery mode segment is expected to grow at the highest rate during the forecast period due to its rising adoption in healthcare organizations for sharing and integrating information from different locations.

Health Providers to Register the Highest Growth, by End User

On the basis of end user, the precision farming software market is segmented into healthcare providers, research centers & government institutes, pharmaceutical & biotechnology companies, and others. Health provider commanded the largest share of the precision software market in 2018 with the growing availability of precision medicine software and a rising emphasis on providing personalized medicine in hospitals.

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(Get key industry insights spread across 280 pages with 256 market data tables & 61 figures & charts from the report)

North America Dominates the Market, While Asia Pacific Leads the Growth

North America commanded the largest share of the precision medicine software market in 2018, followed by Europe and Asia Pacific. The major share of this region is mainly attributed to the increase in the geriatric population suffering from chronic diseases such as cancer. In addition, rising government investment and favorable initiatives for the implementation of precision medicine software further support the growth of the North American precision medicine software market. However, Asia-Pacific region is projected to grow at a significant pace in the next few years, mainly due to the growing burden of genetic diseases throughout the region.

Key Players in the Precision Medicine Software Market

The key players operating in the globalprecision medicine software marketareSyapse, Inc. (U.S.), Fabric Genomics, Inc (U.S.), SOPHiA GENETICS SA (France), Human Longevity, Inc. (U.S.), Sunquest Information Systems, Inc. (U.S.), Lifeomic Health, LLC (U.S.), 2bPrecise LLC (U.S.), Foundation Medicine Inc. (U.S.), PierianDx Inc. (U.S.), Gene42 Inc. (Canada), N-of-One Inc. (A Subsidiary of Qiagen N.V.) (U.S.), and Translational Software Inc. (U.S.).

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Precision Medicine Software Market to Register the Highest Growth Rate by Applications, and Future F - PharmiWeb.com

We asked health execs for their 2020 wish lists. Here’s what they said – FierceHealthcare

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We don't always get what we want. But that shouldn't stop us from wishing, right?

So we reached out to executives around healthcare to get their wish lists for the industry as we enter the next decade.

From taking on regulatory requirements to better harnessing telehealth, here's what they had to say.

Top health industry issues of 2020: Will digital start to show an ROI?

Each year, PwC's Health Research Institute (HRI) names the top issues for the health industry in the coming year. What made the list for 2020? Join HRI for a discussion of the most important trends for providers, insurers, pharma/life sciences and employers.

"With the continued focus on bringing down the cost of healthcare, payers and employers will increasingly join providers in urging people to access the right level of care in lower-acuity settings rather than going to the ED. This will continue the acceleration of consumer-direct access to care options such as in-home, digital and local retail locations."

We need to move away from politics as usual. It is my hope that we can come together to drive solutions that make our healthcare system more efficient and prioritize the patients needs above all. Lets remove regulatory requirements to empower providers to focus on the delivery of care instead of needless administration. As the worlds largest economy, we simply have to prioritize the health of all of our people."

Lloyd Dean, co-CEO of CommonSpirit Health

"Top of mind is increased focus on using telehealth to meet the needs of the most vulnerable: the oldest and youngest on the spectrum as well as the sickest and poorest.

Weve gotten good at targeting telehealth to younger, tech-savvier, affluent patients in their 20s, 30s and 40s. But we need to pay closer attention to where telehealth is needed most and can have a profound impact. Telehealth holds strong potential to help patients with serious and chronic conditions, such as cancer, diabetes and COPD, who typically require more frequent engagement to stay out of the hospital.

Roy Schoenberg, M.D., president and CEO, American Well

"Id like to see the industry adopt more care management policies that encourage patients to manage their safety, healthcare and data via tested digital applications. In 2020 there should be greater adoption and more rapid application of pharmacogenomics into workflow process for patients and prescribers. The fact that the FDA is holding back pharmacogenomics is short-sighted. Pharmacogenomics ought to be fully embraced along with pharmacists who use technology-enabled tools to clinically apply data real-time and store data for future use as well.

Care practices should also be expanded so that pharmacists can be first-line primary care providers through physician collaboration or on their own. As healthcare organizations and payers transform how healthcare is defined and paid for, it will essential for pharmacists to step out from behind the counter to play a larger role in advising care, managing treatment and other clinical care services such as approving refills based on certain parameters."

Orsula V. Knowlton, president, chief marketing/new business development officer,Tabula Rasa HealthCare

"With impeachment looming and the 2020 presidential election set to take center stage, it will be hard for antimicrobial resistance to break through the noise in the media. I hope to read that Washington lawmakers put partisan politics aside and prioritize policies that will save millions of lives. When it comes to legislation to fight superbugs, we need a package of incentivesincluding Medicare reimbursement reforms, pull incentives to reward FDA approval of novel antimicrobials and push incentives to support research and development programs.

The Developing an Innovative Strategy for Antimicrobial Resistant Microorganisms (DISARM) Act is a good first step. The DISARM Act would increase Medicare funding to hospitals that appropriately use innovative antibiotics. The Centers for Medicare & Medicaid Services recently finalized a rule that would allow hospitals to receive additional Medicare reimbursement for prescribing newer antibiotics to treat drug-resistant infections. I hope to see more policy solutions that build on the DISARM Act to incentivize drug companies to fund antibiotic research."

GregFrank, director of Working to Fight AMR

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We asked health execs for their 2020 wish lists. Here's what they said - FierceHealthcare

FDA Approves Digital Therapeutics Technologies to Treat Patient Behavioral Conditions That Interfere with Positive Healthcare Outcomes – DARKDaily.com…

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Clinical laboratories with strong digital and information technology capabilities may find opportunities in this growing field of healthcare

Digital therapeutics (DTx), a growing trend in life sciences technology, is emerging as a popular form of connected healthcare physicians can use to transform patient behavior and improve clinical outcomes. This development may create opportunities for IT-savvy clinical laboratories.

The software applications (apps) and hardware monitoring devices involved in digital therapeutics enable physicians and patients to target and alter specific behaviors that affect certain medical conditions, such as substance abuse or depression. Combined with or without drugs, digital therapeutics are achieving positive results, according to the United Kingdoms PwC (PricewaterhouseCoopers) Health Research Institute (PwC HRI).

Clinical laboratory leaders engaged in precision medicine and pharmacogenomic initiatives will be intrigued by potential opportunities to support digital therapeutics. The FDAs Digital Software Precertification Program has already begun awarding approvals for digital therapeutics that address diabetes and central nervous system disorders, in addition to substance abuse and birth control.

And more FDA approvals for digital therapeutics are expectedin 2020, PwC HRI predicted.

Pharmaceutical and Tech Companies Collaborate on DigitalTherapeutics

A PwC report, titled, Top Health Industry Issues of 2019: The New Health Economy Comes of Age, describes digital therapeutics is an emerging health discipline that uses technology to augment or even replace active drugs in disease treatment.

The report goes on to state that digital therapeutics isreshaping the landscape for new medicines, product reimbursement and regulatoryoversight [and that] new data sharing processes and payment models will beestablished to integrate these products into the broader treatment arsenal andregulatory structure for drug and device approvals.

Connected health services, the report continues, enabled by devices that transmit data or connect to the Internet, give additional visibility into care delivery and new ways to improve patient outcomes.

Digital therapeutics combine apps and monitoring devices forthe management and treatment of medical conditions. While similar to customerwellness apps, digital therapeutics focus on specific clinical outcomes.

The non-profit Digital Therapeutics Alliance says that, unlike common wellness apps, digital therapeutics possess the unique ability to incorporate additional functionalities into a comprehensive portfolio of synchronous products and services. This includes potential integration with mobile health platforms; the provision of complementary diagnostic or adherence interventions; the ability to pair with devices, sensors, or wearables; the delivery of interventions remotely; and integration into electronic prescribing, dispensing, and medical record platforms.

Digital therapeutics are the next frontier, Sai Jasti, Chief Data and Analytics Officer, GlaxoSmithKline (NYSE:GSK), told PwC HRI. I think we will see a lot more collaboration between pharmaceutical and technology companies to drive this forward, ultimately to the benefit of patients.

Digital Therapeutics That Already Have FDA Approval

Digital therapeutics and their connected devices are subjectto the approval process of the federal Food and Drug Administration (FDA), andsome have already received that coveted clearance:

Digital technologies and data science have incredible potential to unlock the next chapter of medical innovation and to help individuals finally take control of their own health in a meaningful way, said Richard Francis, Division Head and CEO, Sandoz, in a press release. New digital therapeutics such as reSET-O also have the potential to fundamentally change how patients interact with their therapies and thus improve patient outcomes.

Both reSET and reSET-O are software mobile apps that use cognitive behavioral therapy (CBT) to help individuals struggling with addictions.

Nearly 50,000 drug overdose deaths involving opioids, including prescription pain medications and heroin, took place in the U.S. in 2017, said Corey McCann, MD, PhD, President and CEO of Pear Therapeutics, in the press release following receiving FDA approval. There is an urgent need for new and innovative therapeutics to address this public health epidemic. This groundbreaking decision by the FDA ushers in a new standard for treating patients with Opioid Use Disorder and it signals a new path for therapeutic software to be used in conjunction with pharmacotherapy to improve efficacy.

We know that women are more likely to use contraceptive methods when they have a variety of methods available to them, and the reality is that not every method is going to work for every woman, Rebecca Simmons, PhD, Research Assistant Professor, Department of Obstetrics and Gynecology, University of Utah, told Health. This is really exciting, in the sense that the more methods we have, the more likely it is that people can find something that works for themand then can avoid unwanted pregnancy.

The role that technology plays in allowing patients to capture meaningful data about whats happening with their heartat the moment when its happening, like the functionality of an on-demand ECGcould be significant in new clinical care models and shared decision-making between people and their healthcare providers, said Nancy Brown, CEO of the American Heart Association, in a press release.

Patients, Providers, and Big Pharma All Like DigitalTherapeutics

There is some evidence that patients and healthcareproviders are intrigued and willing to try digital therapeutics. In a PwC HRI survey,more than 50% of respondents said they would be somewhat or very likely to tryan FDA-approved app or online tool for treatment of a medical condition.

Pharmaceutical companies also are interested in digital therapeutics. A 2018 PwC HRI survey found that 80% of pharmaceutical executives had plans to invest in digital therapeutics in the near future.

A 2019 PwC article, titled, Digital Health Products Need Evidence and Buy-In to Succeed, states that drug companies see the following opportunities for DTx to improve the patient experience:

With precision medicine and pharmacogenetics, clinical laboratoriescould play an essential role in supporting digital therapeutics in the future. Butto truly be competitive in this space and take advantage of the opportunity, medicallaboratories will need to increase their information technology and digitalcapabilities.

JP Schlingman

Related Information:

Digital Therapeutics and Connected Care Reshape the Life Sciences Industry

The Emerging World of Digital Therapeutics

Top Health Industry Issues of 2019: The New Health Economy Comes of Age

Digital Therapeutics: Combining Technology and Evidence-based Medicine to Transform Personalized Patient Care

Everything You Need to Know About the Controversial New Birth Control App

Digital Health Software Precertification (Pre-Cert) Program

Sandoz Inc. and Pear Therapeutics Obtain FDA Clearance for Reset-O to Treat Opioid Use Disorder

Everything You Need to Know About the Controversial New Birth Control App

More than Half of Patients Willing to Use Digital Therapeutic, Study Says

ECG App and Irregular Heart Rhythm Notification Available Today on Apple Watch

Digital Health Products Need Evidence and Buy-in to Succeed

Life Sciences May See Accelerated Digital Health Pathway as Soon as 2020

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FDA Approves Digital Therapeutics Technologies to Treat Patient Behavioral Conditions That Interfere with Positive Healthcare Outcomes - DARKDaily.com...

Global Drug Discovery Market 2019-2027: Market is Poised to Grow at a CAGR of 8.28% from 2019-2027 – PRNewswire

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DUBLIN, Jan. 31, 2020 /PRNewswire/ -- The "Global Drug Discovery Market 2019-2027" report has been added to ResearchAndMarkets.com's offering.

There are significant market opportunities for growth in the drug discovery market. Many healthcare industries are making investments in improving Big Data analytics to reduce inefficiency and provide services at affordable costs. The rising demand for specialty medicine is also expected to boost the small molecule drug discovery and hence, create growth opportunities for the drug discovery market.According to this research, the global drug discovery market is estimated to grow exponentially during the forecasting period 2019-2027 in terms of revenue at a CAGR of 8.28%.

An increase in the aged population, rise in healthcare expenses, growth in lifestyle-oriented diseases, and technological advancements are the major factors that are driving the overall growth of the drug discovery market. Rigid government regulations and poor reimbursement policies are some of the challenges that are restraining market growth.

Regional Outlook

The drug discovery market in Asia-Pacific is projecting an upward trend, and it is fastest-growing among the regions. The increasing GDP of various countries in the region have influenced the market growth. In countries like China and India, public as well as private sectors are investing huge amounts to support drug discovery.

Japan is known for its technological advancements in several industries. For instance, Japanese corporations have invented a revolutionary system named Peptide Discovery Platform System (PPDS), which helps to manually create millions of various kinds of peptides and extract it for the new drug. This invention has given a new approach to drug discovery.

Agilient Technologies, Inc. is a public research, development and manufacturing company that provides bio-analytical solutions and services to different sectors like diagnostics and genomics, chemical analysis, life sciences, electronics industries, and communications across the world. The company conducts its research to produce innovative and advanced products & services. The company was awarded as one of America's Best Employer For Diversity 2019 by Forbes.

Key Topics Covered:

1. Global Drug Discovery Market - Summary

2. Industry Outlook2.1. Market Definition2.2. Porter's Five Forces Model2.3. Pestle Outlook2.4. Regulatory Framework2.5. Value Chain Outlook2.6. Market Attractiveness Index2.7. Key Insight2.8. Market Drivers2.8.1. Growing Aged Population2.8.2. Technological Advancements2.8.3. Rise in the Healthcare Expenditure2.8.4. Surge in Lifestyle Oriented Diseases2.9. Market Restraints2.9.1. Delay in Product Launches2.9.2. Restricting Growth Rate of A Drug Due to Generic Drugs2.10. Market Opportunities2.10.1. Significant Investment By Healthcare Industries in Improving Big-Data Analytical Capabilities2.10.2. Rising Demand for Specialty Medicines2.11. Market Challenges2.11.1. Poor Reimbursements Policies in Emerging Nations2.11.2. Stringent Government Regulations

3. Drug Discovery Market Outlook - By Drug Type3.1. Small Molecule Drug3.2. Biologic Drug

4. Drug Discovery Market Outlook - By Technology4.1. High Throughput Screening4.2. Biochips4.3. Bioinformatics4.4. Pharmacogenomics and Pharmacogenetics4.5. Combinatorial Chemistry4.6. Nanotechnology4.7. Spectroscopy4.8. Metabolomics4.9. Other Technologies

5. Drug Discovery Market Outlook - By Service5.1. Drug Metabolism and Pharmacokinetics (DMPK) Services5.2. Chemical Services5.3. Biological Services5.4. Other Pharmaceutical Services

6. Drug Discovery Market Outlook - By End-User6.1. Research Institutes6.2. Pharmaceutical Companies6.3. Contract Research Organizations (CROs)6.4. Other End-Users

7. Drug Discovery Market - Regional Outlook

8. Company Profiles

9. Research Methodology & Scope

Companies Mentioned

For more information about this report visit https://www.researchandmarkets.com/r/slactg

About ResearchAndMarkets.comResearchAndMarkets.com is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends.

Research and Markets also offers Custom Research services providing focused, comprehensive and tailored research.

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Global Drug Discovery Market 2019-2027: Market is Poised to Grow at a CAGR of 8.28% from 2019-2027 - PRNewswire

Pharmacogenomics – an overview | ScienceDirect Topics

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Clinical Implementation of Pharmacogenomics

Pharmacogenomics has the potential to influence clinically relevant outcomes in drug dosing, efficacy, and toxicity that can result in subsequent recommendations for testing. For many routinely used drugs, pharmacogenomics has provided inconclusive evidence for such testing. A probable reason could be the involvement of both genetic and nongenetic factors and their extent of contribution that determines the clinical relevance of some drugs. Therefore, identification of genetic markers associated with drug responses does not always link to clinically useful predictors of adverse outcomes, and most of the time require independent replication of genotypephenotype association before pursuing clinical implementation.

Lack of readily available resources, feasibility, utility, level of evidence, provider knowledge, cost effectiveness, and ethical, legal, and social issues further adds to the limitations and challenges to implementing pharmacogenomic testing in clinical practice. In order for a genetic marker to be implicated in clinical practice, an association of a genetic marker to a particular trait requires screening of tissues from several individuals, and corresponding functional studies are needed to establish probable association with the trait/phenotype. However, to overcome these challenges there are some pharmacogenomic tests for drugs currently used in clinical practice that have applied value in predicting ADRs and/or drug efficacy. Table 7.2 lists some of these clinically valuable pharmacogenomics tests. These tests are based on distinct genetic variants that have well-validated reproducible and significant impact on the drug therapy. These tests have a strong causal association between genetic polymorphisms and drug responses: a strong indication for clinical utility and high prognostic value. The tests are available both commercially and in academic settings, with many of these tests having clinical guidelines for dose adjustment and alternative medications (Wei et al., 2012). In addition, various international pharmacogenomic consortia have been developed recently to supervise drug response studies.

Table 7.2. Examples of Clinically Valuable Application of Pharmacogenomics Tests in Predicting Drug Response (Efficacy and Toxicity)

A list of current pharmacogenomic guidelines from these consortiums along with a well-annotated pharmacogenomic database has been consolidated into one curated database known as Pharmacogenomics Knowledge Base (PharmGKB) (Thorn et al., 2010). PharmGKB is available via an online portal where users can search on the website by gene, drug, metabolic pathway, and disease. To boost the clinical application of pharmacogenetics and address the barriers to implementation of pharmacogenetic tests into clinical practice CPIC was formed as a shared project between PharmGKB and the Pharmacogenomics Research Network (https://cpicpgx.org). CPIC provides freely available, peer-reviewed, updatable, and detailed gene/drug clinical practice guidelines that enable the translation of genetic laboratory test results into actionable prescribing decisions for specific drugs. The guidelines can focus on genes (e.g., thiopurine methyltransferase and its implications for thiopurines) or around drugs (e.g., warfarin and CYP2C9 and VKORC1). Efforts like PharmGKB and CPIC can help to overcome the confusion created about various pharmacogenetic tests and can help clinical decision making. In addition, the FDA has created a table of Pharmacogenomic Biomarkers in Drug Labeling that lists FDA-approved drugs with pharmacogenomic information in their labeling (http://www.fda.gov/Drugs/ScienceResearch/ResearchAreas/Pharmacogenetics/ucm083378.htm). This biomarker table provides up to date information on genomic markers that have been referred in FDA package inserts for different drugs. Various biomarkers are included in this table, e.g., germ-line or somatic gene variants, functional deficiencies, expression changes, and chromosomal abnormalities as well as selected protein biomarkers that need to be tested before starting treatment in a selected subset of patients. Moreover, with continued integration of pharmacogenomics in clinical trials and drug development, novel important genes and variants that can predict drug efficacy and toxicity will be identified and can be implemented in clinical practice.

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Pharmacogenomics - an overview | ScienceDirect Topics

Global Genetic Testing Markets 2020-2024 | by Hereditary, Newborn, NIPT, Oncology, Pharmacogenomic & Direct to Consumer – ResearchAndMarkets.com -…

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DUBLIN--(BUSINESS WIRE)--The "The Global Genetic Testing Market by Hereditary, Newborn, NIPT, Oncology, Pharmacogenomic and Direct to Consumer, With Executive and Consultant Guides 2020 to 2024" report has been added to ResearchAndMarkets.com's offering.

This report forecasts the market size out to 2024. The report includes detailed breakouts for 14 countries and 5 regions.

Will all newborns receive Whole Genomic Sequencing at birth? What key interest is driving Direct to Consumer?

The role of genetics in health and disease is just now being understood. This new knowledge, combined with lower pricing is driving the Genetic Testing industry to record growth. New drugs may only work for people with a certain genetic makeup, and this too is driving the Genetic Testing Industry. The traditional genetic testing market is growing in volume and growing in the breadth of tests creating a new life for the industry.

Predictive Diagnostics? Pharmacogenomic Testing? Direct to Consumer? Find out about the technology in readily understood terms that explain the jargon. What are the issues? Find opportunities and pitfalls. Understand growth expectations and the ultimate market forecasts for the next five years.

All report data is available in Excel format on request

Key Topics Covered

1. Introduction and Market Definition

1.1 Genetic Testing Definition in This Report

1.2 The Genomics Revolution

1.3 Market Definition

1.3.1 Revenue Market Size

1.4 U.S. Medical Market and laboratory Testing - Perspective

1.4.1 U.S. Medicare Expenditures for Laboratory Testing

2. Market Overview

2.1 Market Participants Play Different Roles

2.1.1 Supplier/pharmaceutical

2.1.2 Independent lab specialized/esoteric

2.1.3 Independent lab national/regional

2.1.4 Independent lab analytical

2.1.5 Public National/regional lab

2.1.6 Hospital lab

2.1.7 Physician lab

2.1.8 DTC Lab

2.1.9 Independent Genetic Testing Lab

2.1.10 Audit Body

2.2 Genetic Tests -Types, Examples and Discussion

2.2.1 Preimplantation Genetic Diagnosis- An Emerging Market

2.2.2 Prenatal Diagnosis - New Technologies Create Opportunity

2.2.3 Newborn Screening

2.2.2 Diagnostic Testing

2.2.3 Carrier Testing

2.2.6 Predictive and Presymptomatic Testing

2.2.7 Pharmacogenomics

2.2.8 Forensic Testing

2.2.9 Parental Testing

2.2.10 Ancestral Testing

2.3 Industry Structure

2.3.1 Hospital's Testing Share

2.3.2 Economies of Scale

2.3.2.1 Hospital vs. Central Lab

2.3.3 Physician Office Lab's

2.3.4 Physician's and POCT

2.4 Market Shares of Key Genetics Players - Analysis

3. Market Trends

3.1 Factors Driving Growth

3.1.1 Genetic Discoveries Creating New Diagnostic Markets

3.1.2 Aging Population a Boon for Diagnostics

3.1.3 Pharmacogenomics Drives Further Growth

3.1.4 Oncology and Liquid Biopsy Enter New Era

3.1.5 Fertility Practice Growth drives market

3.1.6 Direct to Consumer begins to break out

3.2 Factors Limiting Growth

3.2.1 Increased Competition Lowers Price

3.2.2 Lower Costs

3.2.3 Testing usage analysis curtailing growth

3.2.4 Wellness has a downside

3.3 Instrumentation and Automation

3.3.1 Instruments Key to Market Share

3.3.2 Bioinformatics Plays a Role

3.4 Diagnostic Technology Development

3.4.1 Next Generation Sequencing Fuels a Revolution

3.4.2 Impact of NGS on pricing

3.4.3 POCT/Self Testing Disruptive Force

3.4.4 Pharmacogenomics Blurs Diagnosis and Treatment

3.4.5 CGES Testing, A Brave New World

3.4.6 Biochips/Giant magnetoresistance based assay

4. Genetic Testing Recent Developments

4.1.1 Importance of This Section

4.1.2 How to Use This Section

5. Profiles of Key Companies

6. Global Market Size

6.1 Global Market by Country

6.2 Global Market by Application

7. Market Sizes by Application

7.1 Hereditary Testing Market

7.2 Newborn Testing Market

7.3 NIPT Testing Market

7.4 Oncology Testing Market

7.5 Pharmacogenomic Testing Market

7.6 Direct to Consumer Testing Market

8. The Future of Genetic Testing

For more information about this report visit https://www.researchandmarkets.com/r/2llelf

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Global Genetic Testing Markets 2020-2024 | by Hereditary, Newborn, NIPT, Oncology, Pharmacogenomic & Direct to Consumer - ResearchAndMarkets.com -...

Pharmacogenomics: What Is It and How Does DNA Testing for …

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Pharmacogenomics, or the study of how genetics affect your bodys response to medications, is a relatively new and exciting field of science. Scientists are learning more each day about how genetic testing can be used to select the best medication for patients. Genetic testing can help a doctor determine whether a medication will be effective for a patient and provide dosing guidance. It can also help alert clincians to medications that might be potentially harmful to patients.

Genetic testing has become increasingly popular among doctors who prescribe psychiatric medication, in particular antidepressants. Finding the right mental health medication can sometimes be a slow process full of unpleasant side effects. Roughly 40% of people who take an antidepressant will stop taking the medication within the first three months because of side effects or because they believe the medication is ineffective. People who take antidepressants often complain of unpleasant side effects like nausea, sexual dysfunction, headaches, drowsiness, dry mouth, and increased anxiety. When a person experiences side effects, it is easy for them to become discouraged and assume that no medication will help their condition.

Side effects sometimes occur because people metabolize medications differently depending on their genetic code. For example, some people might metabolize an antidepressant more slowly, and a higher concentration of the medication in their body can cause unpleasant side effects. People who metabolize a medication very quickly might have fewer side effects but might need more of the medication to effectively treat depressive symptoms. Therefore, doctors are increasingly recommending genetic testing for depression medications to find the proper dosage and the right medication which may result in fewer side effects.

Take our 2-minute Depression quiz to see if you may benefit from further diagnosis and treatment.

Genetic testing is designed to be easy and painless. To complete the test, a laboratory collects a small sample of blood or saliva from the patient. The sample is usually sent to a pharmacogenomic testing laboratory to be analyzed. This lab sequences the DNA and analyzes any variations or changes in specific genes that are associated with how you respond to a particular medication. Testing for a specific kind of medication only has to be done once, but you may require additional pharmacogenomic testing if your doctor wants to evaluate you for another type of medication.

Because the field is still in its infancy, there is not pharmacogenomic testing available for every medication. But genetic testing is available for many of the medications that treat psychiatric conditions including anxiety, depression, bipolar disorder, schizophrenia, panic disorder, obsessive compulsive disorder (OCD), and post-traumatic stress disorder (PTSD). Here are just a few of the many psychiatric medications currently available for testing:

It is important to note that genetic testing is not always completely accurate. Because the field is still new, there are only a few studies supporting the claim that patients who undergo genetic testing for medication will have more positive outcomes than patients who do not. There also are limitations to what genetic testing can tell you about how your body will metabolize a medication. There is not one pharmacogenomic test that will provide information about all medications so you may need more than one test if you are taking more multiple meds. And, some medications cant be tested using this method (i.e. aspirin and other over-the-counter pain relievers).

Sometimes genes have a strong influence over how the medication works, and sometimes other factors are more influential. These factors can include gender, age, nutrition, smoking history, and pregnancy. Your other medical conditions and any medications you takeboth prescription and over-the-countercan also affect how medications are metabolized. Your doctor may take all of these factors into consideration when they prescribe you a medication and when they consider whether to recommend that you complete genetic testing.

Insurance coverage for genetic testing may vary depending on your insurance plan and personal history. You or your doctor may be required to submit documentation proving that you have a certain diagnosis or have experienced difficulty finding the right medication. It may be helpful to ask your healthcare provider for the specific procedure and medical billing codes for the lab tests theyd like to order before calling your insurance company about coverage. If your insurance doesnt cover the cost, check with the genetic testing company to see if they offer any payment assistancethese tests can cost a few hundred dollars.

Treating mental illness usually involves a combination of medication, psychotherapy, and psychoeducation. So its important to participate in other kinds of treatment and self-care activities while taking medication. Your diet, sleep, exercise, and other factors can also play a role in your mood and how your body responds to medication. As your body ages and develops, you may also find that medications will need to be adjusted by your doctor.

Talk to your doctor about whether genetic testing could be useful for helping you find the right medication. Patients who are in crisis or who have a history of difficulty in finding the right medication are sometimes more likely to be recommended for genetic testing. Your primary care doctor may also have to refer you to a psychiatrist to provide more specialized knowledge in selecting a medication or to evaluate whether genetic testing could be beneficial.

To prepare for your appointment, you may want to prepare notes about the following information:

Genetic testing isnt a magic solution to a persons mental health challenges, but it can sometimes provide your doctor with important information about how your body will metabolize certain medications. Many people, however, find the right medication for their symptoms without the use of genetic testing. So dont be discouraged if it is not an option or not covered by your insurance. It never hurts, however, to start a conversation with your doctor about your options. The testing may not inform him of the perfect medication, but it can alert a physician as to what medications are likely to cause adverse effects or be ineffective. So dont hesitate to talk to your healthcare provider about whether you might benefit from pharmacogenomic testing.

Last Updated: Jul 31, 2018

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Pharmacogenomics and Personalized Medicine | NorthShore

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The right drug, at the right dose, at the right time. This is the power of pharmacogenomics.

When it comes to medications, a drug that works well for one person may not work well for another. A standard dosage may achieve the desired treatment outcome in most patients yet could result in side effects or no therapeutic benefit at all in others.

We know that 98% of patients who take the MedClueRx test have at least one result that may impact their care. Pharmacogenomics testing is particularly valuable before you have tried several medications for a condition. It is also useful if you feel your medications are not working or have experienced adverse side effects.

*Do not change or stop taking any medicine based on a genetic test report without consulting your healthcare provider. This test is not intended to inform you about your current state of health, including whether or not you should take a medication or how much you should take. This test does not diagnose any health conditions and is not a substitute for visiting your health care provider. Discuss the results of the genetic test with your healthcare provider, including whether the medication label includes information on how to use genetic information to determine dosage. Medicine should always be taken as prescribed by your healthcare provider.

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Myriad Neuroscience

Mason, OH 45040

ISR will undergo continued pharmacogenomic and product sales training. Communicate with healthcare providers and their staff about pharmacogenomic testing and

Translational Medicine group at AstraZeneca is looking for a highly motivated scientist with experience in development of molecular assays and expertise in

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$55,000 - $65,000 a year

Lighthouse Lab Services is representing a laboratory billing and RCM management company, based out of Albany NY, that is looking to hire two account managers to

(medicinal chemistry, pharmacology, toxicology, pharmacogenomics and biopharmaceutics) for Pharm.D. The assistant or associate professor is a full-time, tenure

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Discovery and Clinical Pharmacogenomics (Kenilworth, NJ; Our company's Genetics and Pharmacogenomics team is currently recruiting for summer interns.

Translational Medicine group at AstraZeneca is looking for a highly motivated scientist with experience in development of molecular assays and expertise in

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Early focus is on pharmacogenomics, test guidance, rare diagnosis, risk prediction, and screening. Beacon Oncology Information System is built for the

Ethical, Legal, Social Issues in Genomics and Pharmacogenomics. Epigenetics and pharmacogenomics and their role in todays healthcare. Each term is eight weeks.

One study will recruit 1800 adults of African ancestry with hypertension to evaluate the impact of returning high-risk APOL1 genetic test results to patients

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Genes Advice | Pharmacogenomics

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Have you or a loved one ever had a bad reaction or unusual side effects when taking a medicine? Reading the long list of allergies, warnings, interactions and other possible complications on any prescription drug leaflet can be scary. Why is it that some drugs work great for some people but dont work well for others?

With 1,222 new drugs approved by the Food and Drug Administration (FDA) between 1950 and 2008, there are many options on the market (Munos, 2009, Nature Reviews Drug Discovery).With so many options, finding the right medication can be a drawn-out process of trial and error for the patient and the provider. As a result, complications are becoming alarmingly common. In 2015, the FDA received nearly 1.3 million reports ofdrug interactions, a rate that more than doubled in six years. Deaths from severe allergic reactions are also on the rise. *How your body reacts to any given medicine will be different from that of your spouse, your cousin, your best friend, your next-door neighbor, and your favorite grocery checkout clerk. (Reactions may even differ with the over-the-counter-drugs like aspirin or dietary supplements that the very same checkout clerkrang up for you!)

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Genes Advice | Pharmacogenomics

MediMap – pharmacogenomic testing for adults and children …

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MediMap is a one-time Pharmacogenomics (or "PGx") test that may indicate how a person will respond to specific prescription medications. Your MediMap test results can help guide your healthcare providers to ensure better medication choices and doses based on your genetic makeup... leading to more effective illness management and improved health. The future of medicine is about putting into practice the knowledge that with prescription medicines and dosage amounts, one size does NOT fit all.

The MediMap test is available for all ages; everyone in the family including newborns can benefit from pharmacogenomics testing.

Please note: some studies may overlap; for example, a MediMap multi-drug panel may include the specific drug(s) you were looking to be tested for within a condition-specific panel. A genetic counselor will go over your best options during your consult.

What is pharmacogenomics?+

Pharmacogenomics is the study of how people's genes affect their response to medications.The term pharmacogenomics (also called PGx) is a combination of pharmacology (the study of medications) and genomics (the study of how peoples genetic information can influence their health).PGx may be used to help choose the best medications and doses for you.

What is MediMap?+

MediMap is a pharmacogenomic test that helps guide you and your healthcare providers to better medication choices and doses for you. Until recently, most medicines have been developed and given to patients in a "one size fits all" approach.However, people respond differently to medications due, in part, to their genetic makeup. While some people will find a medication helpful, others may not respond to that medication at all. Some people will need a dose that is higher or lower than what is usually prescribed. Even others may have negative side effects (called adverse drug reactions).MediMap looks at specific genetic changes (called variants) that influence a persons response to many medications.

Does MediMap cover all prescription medications?+

While the number of personalized medicines increases steadily every year, not all medications can yet be connected with genetic changes that influence a persons response to medications.Also, there are other medications (besides those included in our tests) that have been reported to be affected by pharmacogenomic variants. However, at this time, there is not enough evidence available to include them on our reports. To help you better understand differences between evidence levels, we differentiate between "actionable" and "informative" information on our reports."Actionable" means there are expert recommendations to help guide clinical treatment; and "informative" means there is insufficient evidence, at this time, and clinical use of this information is optional.You can see which prescription medications are covered in each MediMap tests on our MediMap test comparison sheet.

Which MediMap test is best for me?+

At your appointment, you will meet with a genetic counselor to discuss available testing options. Factors to consider may include: medications you are currently taking, those you might be prescribed in the future, and a history of medication side effects or ineffectiveness. Our goal is for you to have a good understanding of how pharmacogenomic testing may help you, and allow you and your physician to make the best decisions for you.

Are my results confidential?+

Yes. The results will be entered into the secure Inova electronic medical record, and a copy of the report will be mailed to your home. You are responsible for sharing your test results with your healthcare providers.

What will happen to my DNA sample?+

Your DNA sample will be kept for at least 90 days after the MediMap report has been sent to you. At that time, the sample will be disposed or de-identified (name and other identifiers are removed) depending on your selection at the time you authorize the test. If your sample is de-identified, it may be used for quality control purposes, to develop new tests, or for educational activities. No clinical tests other than MediMap will be performed using your DNA sample.

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MediMap - pharmacogenomic testing for adults and children ...