Large differences in lifetime physician earnings

SACRAMENTO A national study has found that earnings over the course of the careers of primary-care physicians averaged as much as $2.8 million less than the earnings of their specialist colleagues, potentially making primary care a less attractive choice for medical school graduates and exacerbating the already significant shortage of medical generalists.

The results, published online in the journal Medical Care, lead the study's authors to recommend reducing disparities in physician pay to ensure adequate access to primary care, which has been shown to improve health and reduce health-care costs.

"The need for primary-care providers is greater than ever before and expected to grow as millions more Americans become insured under the Affordable Care Act," said J. Paul Leigh, lead author of the study, professor of public health sciences and researcher with the UC Davis Center for Healthcare Policy and Research. "Without a better payment structure, there will be extraordinary demands on an already scarce resource."

According to projections by the Association of American Medical Colleges, the nation is likely to face a shortage of more than 65,000 primary-care physicians by 2025.

For the nationwide study, a follow-up to 2010 research by Leigh and his colleagues on differences in annual wages by specialty, the investigators compared lifetime earnings to demonstrate how annual wage differences accumulate over physicians' careers. The earnings data came from the 2004-05 Community Tracking Study, a periodic evaluation of physician demographic, geographic and market trends.

To ensure valid comparisons, the data were adjusted to account for factors that affect earnings, including age, sex, race, board certification, graduation from a foreign medical school, rural residence, employment by an academic medical school and residency program length.

Incomes were then evaluated for more than 6,000 doctors practicing in 41 specialties. When merged into four broad career categories, lifetime earnings in surgery, internal medicine and pediatric subspecialties, and all other medical specialties averaged from $761,402 to $1,587,722 higher than in primary care:

The earnings differences were more dramatic when compared as 41 separate specialties. Medical oncologists, for instance, earn up to $7,127,543 during a 35-year career, while family medicine practitioners earn as low as $2,838,637.

Leigh surmised that one reason for the earnings differences is the tendency for Medicare administrators to utilize recommendations from an American Medical Association committee on physician pay that price specialist procedures far higher than primary-care office visits. Private insurance companies, in turn, tend to adopt Medicare pay rates.

The authors noted that efforts are under way to resolve physician pay differences. For example, the Affordable Care Act requires states to pay primary-care physicians no less than 100 percent of Medicare payment rates for primary-care services provided to Medicaid patients. The study's senior author, Richard Kravitz, a UC Davis professor of internal medicine, also serves on an independent commission to assess physician pay.

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Large differences in lifetime physician earnings

Medical School to Augustinian Order unanimously

On Wednesday after noon the National Audit Office Accounts Committee approved unanimously a parliamentary resolution to transfer the Medical School site at Guardamangia to the Augustinian Order to use it as a primary school for 400 children. Both government and Opposition MPs sitting on the committee voted in favour and so there is no need for parliament to debate and pass this motion in a plenary session.

The parliamentary resolution passes the Medical School site to the Augustinian order on lease for 99 years for 1,000 a year as rent. Sports and other educational facilities can be developed on the site and even the 2,177 sq m car park in front of the Medical School building can be made use of by the school.

The Augustinian Order is committing itself to spend at least 1,000,000 on the primary school project and that the work on it will start within 10 weeks of the Malta Environment and Planning Authority (MEPA) issuing the necessary permits.

In exchange for the Medical School site, the Augustinian Order will transfer to government the site on which they were going to build the primary school for a lease of 99 years at 900 per year. Government will pass back this land to the Order on condition that no development is carried out on it and the residents living in the area will not have their view blocked by any building.

After working hard for more than three years on a new primary school for St Augustines College, MEPA last February turned down the application by five votes to four and wanted the extension to have two and not three floors as planned, making the whole project too small and costly to be viable. On 9 February 2012 the Prime Minister was given a petition signed by parents after the students of the school, parents and teachers met near the War Monument in Floriana and walked to Castille.

Neighbours of the college had objecting to the project as the new building would block their view and devalue their property.

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Medical School to Augustinian Order unanimously

Nationals support new medical school at Charles Sturt

Sept. 18, 2012, 4 a.m.

DELEGATES at the Nationals' Federal Conference carried a motion on Sunday supporting Charles Sturt University's proposal to establish a new medical school to address chronic shortages of doctors in rural and regional Australia.

Charles Sturt University (CSU) vice-chancellor Professor Andrew Vann said, "We welcome this very public commitment by The Nationals to the establishment of a new medical school at Charles Sturt University.

He said the support followed news this week that more than 21,000 Australians had signed up on Facebook as supporters of Charles Sturt University's planned medical school.

"While we remain hopeful that the current government will fund this initiative in the next federal budget, it is important for rural and regional communities to know that the Nationals are committed to this initiative," Professor Vann said.

"I think there is a growing recognition across all political parties of the serious impact that the rural doctor shortage has on the lives of families and individuals in our communities.

"There also appears to be an increased awareness that people will not live in rural towns, let alone move here, if they can't get access to a doctor when they need one."

He said the commitment by The Nationals follows mounting evidence current rural medical education strategies are not working, and the need to focus more on resources for rurally-based and delivered programs if government was serious about addressing rural doctor shortages.

"For example, a cross-party Senate inquiry into rural medical workforce shortages reported in August this year that city medical schools had consistently failed to meet minimum recruitment targets for rural medical students, despite all the evidence that a rural doctor is significantly more likely to have come from a rural area and been trained in a rural area," Professor Vann said.

"Charles Sturt University's proposed solution to the rural doctor shortage is not only supported by a wealth of national and international evidence, it has the overwhelming support of rural and regional Australians."

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Nationals support new medical school at Charles Sturt

Med School admits largest class yet

The Alpert Medical School welcomed its largest class ever this year totalling 120 students following the opening of the schools downtown facility last fall. With the building constructed in downtown Providences Knowledge District able to accommodate more students, the school matriculated 11 additional students in this years class, up from 109 in the class of 2015. The school has expanded from 310 students in 2001 to 421 students this year, according to Ed Wing, dean of medicine and biological sciences.

The admittance of the Med Schools largest-ever class was made possible by the new facility, Wing said. Admitting classes of 120 will expand the school to 480 students in the next few years, he said.

Its a terrific building, Wing said, adding that the schools old space in the BioMedical Center did not allow for expansion. Everything in the (new) building has allowed us to provide better education.

The Med School also witnessed a surge in applications for spots in the class of 2016, with a roughly 20 percent increase from 2,825 applicants in 2011 to 3,344 applications in 2012, according to Philip Gruppuso, associate dean of medical education and professor of pediatrics.

There is in general a physician shortage in the United States, Gruppuso said. He noted that the Association of American Medical Colleges has called for a substantial increase in the countrys supply of doctors and that the University is hoping to aid this goal. Gruppuso said the Med Schools expansion was part of a long-term process that occurred after administrators received permission from the Liaison Committee on Medical Education, the national accrediting organization for medical degree programs.

Wing said administrators have nothing definite planned to expand the student body any further than 480 students.

The Med School hired more staff to accommodate the larger building, but they did not need to hire more faculty members, Wing said, adding that the school boasts a total of 2,000 faculty members, including 600 full-time clinical faculty. The Med School revamped its curriculum but did not add additional classes or expand the size of courses.

Gruppuso said the University is still considered a small medical school according to national rankings of medical degree programs by size.

We had space and resources and faculty to be able to meet the needs of this number of students, he said. We were very confident this (expansion) was not going to result in any kind of erosion of the quality of the medical program.

As part of its expansion, the Med School introduced a new academy model of advising and training last year, with each class divided into three academies of around 40 students in order to facilitate greater advising services and a better sense of community. Each academy space provides locker and study space, designated advisers and other training services to students to help break down the student body into smaller sections.

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Women face cultural barriers in academic medicine

Although men and women working in academic medicine strive toward advancement, significantly fewer women achieve leadership positions, says a study in the Journal of General Internal Medicine.

For the past decade, women have made up about 50% of medical students, according to the Assn. of American Medical Colleges. Meanwhile, the average medical school has 43 female full professors compared with 192 male full professors, said Linda Pololi, MD, lead study author and senior scientist at the Womens Studies Research Center at Brandeis University in Massachusetts.

Those numbers are still absolutely shocking, and without a good explanation, she said.

To gain insight into the cultural barriers women face in academic medicine, researchers surveyed 4,578 full-time faculty at 26 U.S. medical schools. They found that women reported a lower sense of belonging and support and were more pessimistic about gender equity and their chances for advancement compared with men. Women also were less likely to believe that their institutions were family-friendly or to see their values as aligning with the institutions.

The average medical school has 43 female full professors and 192 male full professors.

The findings, published online Aug. 31, demonstrate that medical schools have failed to create an environment where women feel fully accepted and supported to succeed, said Dr. Pololi, director and principal investigator of the National Initiative on Gender, Culture and Leadership in Medicine, also known as C-Change, which engages medical schools in research aimed at attaining equality in academic medicine.

The study proves wrong the notion that women are less ambitious than men. It shows that both genders have equal leadership aspirations and are equally engaged in their work, she said.

Women care very deeply about having a rich professional life, Dr. Pololi said.

The findings are not surprising and reinforce previous research, said Page S. Morahan, PhD, founding director and director of research at the Hedwig van Ameringen Executive Leadership in Academic Medicine Program for Women at Drexel University College of Medicine in Philadelphia.

We have seen this over and over again, she said.

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Women face cultural barriers in academic medicine

Mafia Medicine: Jordana Spiro, Josh Berman Weigh In on The Mob Doctor

Jordana Spiro

"What would have happened if Meadow Soprano had gone on to medical school and become a doctor?" That's the question writer-producer Josh Berman said he found himself wondering when Jamie-Lynn Sigler (who played Tony Soprano's brainy daughter on The Sopranos) guest-starred on his show Drop Dead Diva.

Fall Preview: Get scoop on all of this season's new shows

Thus was planted the seed for The Mob Doctor, Berman's new series that stars Jordana Spiro as Dr. Grace Devlin, a surgeon who tries to balance her professional career with a secret side job: providing medical services for the Chicago Mafia in order to pay off a debt owed by her brother (Jesse Lee Soffer).

Berman says that after Sigler's appearance on Drop Dead Diva, he and co-producer Rob Wright started researching real-life Mob doctors. "We were shocked," he said. "It is the underbelly of organized crime their medical fixers, so to speak. So when we found out that this actually did exist, it became even more compelling and that's the point we decided, 'We have to write this.'"

See Mob Doctor's Jordana Spiro and more fall stars to watch

Inspired by one nonfiction account in particular, Ron Felber's Il Dottore: The Double Life of a Mafia Doctor, Wright and Berman started developing the character of Grace. Berman says the series will balance the medical drama with Grace's personal life story lines bookended by her relationships with her boyfriend/colleague (Zach Gilford) and former Mafia boss/family friend Constantine (William Forsythe).

"We have some episodes that take place predominantly in the hospital, and then some that take place predominantly in the field," Berman said. "I like to refer to those cases as the dirty medicine cases, because we get to tell stories without the bureaucracy of a hospital, and to me that's what's so compelling. ... When Grace is in the field, the only thing she needs to do is worry about the patient. And I think she takes that energy and that passion back into the hospital with her, which kind of gives her that 'I don't give a damn' attitude when it comes to placating her bosses. Instead, she puts her patients' interests first."

Spiro, who previously starred in TBS' comedy My Boys, said she was drawn to the role due to the moral dilemmas Grace faces as she tries to extract herself from the Mafia life. (Her father was a minor player in the Mob.) In the pilot episode, for instance, Grace receives a message to kill a patient, an informant who's brought into her hospital."This woman is making choices that are very morally conflicted and yet, at the beginning, it's to save her family," Spiro says. "And so this question becomes, 'How far do you go, and where is that line that you absolutely won't cross? And what happens when that line keeps edging further and further away?'"

The Mob Doctor's antihero will cross the line

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Mafia Medicine: Jordana Spiro, Josh Berman Weigh In on The Mob Doctor

Medical schools look to link up for AEC

WANNAPA KHAOPA THE NATION September 18, 2012 1:00 am

Professor Adeeba Binti Kamarulzaman from Malaysia responded to a question about the urgent matters to be discussed in terms of research collaboration, saying the academics would see how they could jointly deal with problems that every country in the region faces - diseases such as flu and diabetes.

Prof Agnes D Mejia from the Philippines said having done community based research on diabetes, HIV prevention, E-coli and diarrhoea; the Philippines would share its findings.

Prof Udom said: "In preparation for the Asean Economic Community in 2015, the medical schools have to discuss how to upgrade curriculum, learning processes, medical services and research together. We have to link our patient care systems to support free flow of patients in Asean."

The First Asean Deans' Summit will run until tomorrow, with the theme "Connecting Asean Medical Schools towards One Community". It aims to promote collaboration among leading medical schools in Asean to leverage medical education and health systems towards international excellence and to be prepared to work as one community by 2015.

They will sign the Asean Medical School's Intention Declaration tomorrow to establish and reinforce collaboration and a network among their medical schools. They plan to share human resources and provide capacity building for medical education and research and health systems in Asean countries.

Asked about doctor mobility in Asean, Dr Alonkone Phengsavanh from Laos, said: "We should set up new regulations among medical associations of each country, and the first thing is medical licences. [Each] Health Ministry should be aware about this issue. The country should think about a 'brain drain'.

Udom said he hoped that their collaboration - coming together to look at curricula and (medical) facilities they could share to help each other - would help lift every country's standards to a similar level.

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Medical schools look to link up for AEC

School: Doctor was disciplined for viewing adult pornography

From Chris Boyette, CNN

updated 10:44 PM EDT, Fri September 14, 2012

STORY HIGHLIGHTS

(CNN) -- The Boston Children's Hospital pediatric doctor charged with receipt of child pornography was disciplined for using a school computer to access adult pornography when he was medical director at Phillips Academy boarding school, school officials said Friday.

Richard Keller, 56, who is also a pediatrics clinical instructor at Harvard Medical School, was the medical director at Philips Academy for 19 years, according to John Palfrey, the head of the school.

In an e-mail to faculty, staff, students, alumni and parents on Friday, Palfrey said Keller was reprimanded in 1999 for using an academy computer to access pornography that featured adult subjects, and in 2002 was reprimanded for showing an inappropriate cartoon to students.

According to Palfrey, Keller was cited for "poor management and poor judgment," leading the Andover, Massachusetts, school to place him on administrative probation in 2009.

Palfrey went on to say that as recently as 2010, Keller sent an inappropriate voice-mail message to a colleague at the school. A claim by Keller that the school had discriminated against him was determined to be "groundless," according to Palfrey.

In April 2011, the academy informed Keller that his contract would not be renewed. The doctor resigned that month, the school said.

"We have no reason to believe that any of our students were involved in, or affected by, Dr. Keller's alleged criminal behavior," Palfrey said, adding the federal case made Thursday against Keller is unrelated to alleged misconduct at Phillips.

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School: Doctor was disciplined for viewing adult pornography

School: Boston doctor was disciplined for viewing adult pornography

From Chris Boyette, CNN

updated 10:44 PM EDT, Fri September 14, 2012

STORY HIGHLIGHTS

(CNN) -- The Boston Children's Hospital pediatric doctor charged with receipt of child pornography was disciplined for using a school computer to access adult pornography when he was medical director at Phillips Academy boarding school, school officials said Friday.

Richard Keller, 56, who is also a pediatrics clinical instructor at Harvard Medical School, was the medical director at Philips Academy for 19 years, according to John Palfrey, the head of the school.

In an e-mail to faculty, staff, students, alumni and parents on Friday, Palfrey said Keller was reprimanded in 1999 for using an academy computer to access pornography that featured adult subjects, and in 2002 was reprimanded for showing an inappropriate cartoon to students.

According to Palfrey, Keller was cited for "poor management and poor judgment," leading the Andover, Massachusetts, school to place him on administrative probation in 2009.

Palfrey went on to say that as recently as 2010, Keller sent an inappropriate voice-mail message to a colleague at the school. A claim by Keller that the school had discriminated against him was determined to be "groundless," according to Palfrey.

In April 2011, the academy informed Keller that his contract would not be renewed. The doctor resigned that month, the school said.

"We have no reason to believe that any of our students were involved in, or affected by, Dr. Keller's alleged criminal behavior," Palfrey said, adding the federal case made Thursday against Keller is unrelated to alleged misconduct at Phillips.

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School: Boston doctor was disciplined for viewing adult pornography

School: Doctor disciplined for viewing adult porn

iStock / DOConnell

The Boston Children's Hospital pediatric doctor charged with receipt of child pornography was disciplined for using a school computer to access adult pornography when he was medical director at Phillips Academy boarding school, school officials said Friday.

Richard Keller, 56, who is also a pediatrics clinical instructor at Harvard Medical School, was the medical director at Philips Academy for 19 years, according to John Palfrey, the head of the school.

In an e-mail to faculty, staff, students, alumni and parents on Friday, Palfrey said Keller was reprimanded in 1999 for using an academy computer to access pornography that featured adult subjects, and in 2002 was reprimanded for showing an inappropriate cartoon to students.

According to Palfrey, Keller was cited for "poor management and poor judgment," leading the Andover, Massachusetts, school to place him on administrative probation in 2009.

Palfrey went on to say that as recently as 2010, Keller sent an inappropriate voice-mail message to a colleague at the school. A claim by Keller that the school had discriminated against him was determined to be "groundless," according to Palfrey.

In April 2011, the academy informed Keller that his contract would not be renewed. The doctor resigned that month, the school said.

"We have no reason to believe that any of our students were involved in, or affected by, Dr. Keller's alleged criminal behavior," Palfrey said, adding the federal case made Thursday against Keller is unrelated to alleged misconduct at Phillips.

Keller's name came to the attention of authorities after the U.S. Postal Inspection Service began a 2010 investigation into a movie production company that sold films featuring minor boys, according to the criminal complaint.

Investigators conducted a review of the company's customer database and located alleged customer Richard Keller, who had two addresses listed, authorities said.

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School: Doctor disciplined for viewing adult porn

Penn State Milton S. Hershey Medical Center will tout record research funding, new programs

A newly-launched medical school program in State College will be highlighted Wednesday during the annual open meeting of the Penn State Milton S. Hershey Medical Center board of directors. The program presently involves 13 medical students who are in their third year, and spent their first two years at Derry Twp.-based Penn State College of Medicine.

The purpose is to train doctors closer to rural communities where they will eventually work, and help remedy shortages in those areas. The program is a collaboration involving Penn State-Hershey, Mount Nittany Medical Center and other medical providers based in the State College area.

According to a news release, the meeting also will highlight items including the record $107 million in research funding received by the medical center and Penn State College of Medicine during the most recent fiscal year. The figure represents a $1.5 million increase from last year, with about $65 million coming from the National Institutes of Health.

The meeting is expected to further highlight the center's new Institute for Personalized Medicine. The goal of personalized medicine is to tailor treatments based on the patient's biologic and genetic makeup.

Penn State-Hershey, which was founded in 1963, has 491 beds and admits about 27,000 patients annually. Its most recent class of medical school graduates included 131 doctors, and it annually gets about 7,300 applicants for 145 medical school slots, according to the medical center.

The hour-long board meeting, which is open to the public, is scheduled to begin at 4 p.m. in the Edward P. "Ted" Junker III Auditorium at the medical center.

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Penn State Milton S. Hershey Medical Center will tout record research funding, new programs

Fitness author brings multiple disciplines to his craft

Dr. D. Levi Harrison, an orthopedic surgeon and UC Davis Medical School graduate, visited his alma mater in August to talk to students about the role that fitness plays in medical education.

Harrison, who recently published a book titled "The Art of Fitness: A Journey to Self Enhancement" (Brio Press, $39.95, 232 pages) holds undergraduate degrees in electrical engineering and romance languages, and graduate degrees in physics and French in addition to his medical degree. He has a private practice as a hand specialist in Glendale.

Why did you decide to write a fitness book?

It's about letting people know that fitness and exercise are lifestyle choices that we have to make to not only have the aesthetic of looking healthy on the outside, which is the superficial part of fitness. I wrote the book so people can understand that fitness is from the inside out.

What makes your book different from other fitness books?

It's geared toward anyone of any fitness level. The book is about helping people to not only get healthy, but make lifestyle changes. The goals of the book aren't about achieving an aesthetic. The goals are to decrease the rates of diabetes, hyper-tension, cardiovascular disease, stroke, cholesterolemia and obesity.

The book is really there to let people know that they shouldn't compare themselves to anybody. The goal is to remind people that your body is yours and that where you are today is a good place.

So if you're overweight, you're underweight, you're not very fit, that's OK. Every day you get to start the journey again.

Where do you think fitness education fits into today's medical school?

I definitely think fitness, health and nutrition should be a greater part of all medical school education.

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Fitness author brings multiple disciplines to his craft

400 doctors say they support a tax increase for medical school services in Austin

By Mary Ann Roser

More than 400 Austin-area doctors are backing a Nov. 6 ballot proposition for a big increase in Travis County property taxes to support services for a planned medical school and other programs, a political action committee said Wednesday.

"I think Proposition 1 is about health care for families, and doctors are interested in that," said Lynda Rife, a spokeswoman for the Keep Austin Healthy PAC.

She said her release of the doctors' names was the culmination of a grass-roots effort that took about a week with doctors contacting each other and expressing support for the proposition.

Central Health, which oversees health care services for indigent residents of Travis County, is asking voters to approve a 63 percent increase in property taxes from 7.89 cents per $100 of assessed value to 12.9 cents. The money raised, estimated at $54 million, would pay for health services provided by medical school faculty, residents and students, as well as help pay for a teaching hospital site and other health care programs.

"Our doctors understand how this initiative will help raise funds that will be used to further enhance care, improve the efficiency of care, and provide greater access to care for patients in our community," Dr. Norman Chenven, founder of Austin Regional Clinic, said in a statement.

Michael Rotman, a retired Austin cardiologist, said he fears duplicating services and driving up costs.

Contact Mary Ann Roser at 445-3619

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400 doctors say they support a tax increase for medical school services in Austin

UMASS Medical School faculty annotate human genome for ENCODE project

Public release date: 5-Sep-2012 [ | E-mail | Share ]

Contact: Jim Fessenden james.fessenden@umassmed.edu 508-856-2000 University of Massachusetts Medical School

WORCESTER, MA The first comprehensive decoding and annotation of the human genome is being published today by the ENCyclopedia Of DNA Elements (ENCODE) project, an international consortium of scientists from 32 institutions, including the University of Massachusetts Medical School. The groundbreaking ENCODE discovery appears in a set of 30 papers in Nature, Genome Research and Genome Biology.

Using data generated from 1,649 experiments with prominent contributions from the labs of UMMS professors Job Dekker and Zhiping Weng the group has assigned biochemical functions for an astounding 80 percent of the human genome. These findings promise to fundamentally change our understanding of how the tens of thousands of genes and hundreds of thousands of gene regulatory elements, or switches, contained in the human genome, interact in an overlapping regulatory network to determine human biology and disease.

As little as a decade ago, the human genome was viewed by scientists as a collection of independent genes that contained the instructions for making the proteins that carried out the basic biological functions necessary for life. Driven by this premise, most researchers focused on understanding the relatively small portion of the genome that made up protein-coding genes while the non-coding portion of the genome often referred to as "junk DNA" received little attention. The sequencing of the human genome in 2003 and more recent efforts by the ENCODE consortium, which is funded by the National Human Genome Research Institute (NHGRI) of the National Institutes of Health (NIH), and others over the last decade, has begun to fundamentally change researchers' views on the importance of the non-coding portion of the genome.

Scientists now know that the protein-coding portions of the genome make up only one part of our genetic picture. Of equal importance are those areas of the genome that regulate genes. These elements, such as regulatory DNA elements and non-coding RNA, control when a gene is turned on and off and can also amplify or curtail expression of a gene. Even a small change in when a gene is turned on can have a huge biological impact, or in specific circumstances, contribute to disease.

Taken together, genes and their regulatory elements create a vast network of overlapping systems that carry out the basic biological processes necessary for life, a system that scientists are only now beginning to understand. Using a wide variety of experimental and computational approaches, members of the ENCODE consortium have generated comprehensive information about the identities, locations and characteristics of human genes and regulatory switches throughout the genome. This data represents an expansive resource that biomedical researchers can use to begin unraveling how this system works and how it contributes to disease.

"This work provides a critical map of tens of thousands of genes and hundreds of thousands of regulatory switches that are scattered all over the 3 billion nucleotides of the genome," said Dr. Dekker, PhD, professor of biochemistry & molecular pharmacology and co-director of the Program in Systems Biology at UMMS. "As a group, we've identified more than 4 million sites that through binding specific proteins affect biological function."

Three dimensional wiring of the genome

What this map doesn't tell scientists, though, is which switches or elements regulate which genes. That is where the work of Dekker, the lead author on one of the six ENCODE papers that appear in Nature, provides unique insights. Over the last decade, Dekker has pioneered the development of chromosome conformation capture technologies (3C) and combined it with next-generation sequencing technologies (5C) to create three-dimensional models of folded chromosomes. In turn, these models can be used to determine which parts of the genome, when folded, come in physical contact.

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UMASS Medical School faculty annotate human genome for ENCODE project

Medical School becomes St Augustine Primary School

Government has tabled a parliamentary resolution to transfer the Medical School site at Guardamangia to the Augustinian Order to use it as a primary school for 400 children.

Government is proposing to lease it to the Order for 99 years for 1,000 a year as rent. Sports and other educational facilities can be developed on the site and even the 2,177 sq m car park in front of the Medical School building can be made use of by the school.

The Augustinian Order is committing itself to spend at least 1,000,000 on the primary school project and that the work on it will start within 10 weeks of the Malta Environment and Planning Authority (MEPA) issues the necessary permits.

In exchange for the Medical School site, the Augustinian Order will transfer to government the site on which they were going to build the primary school for a lease of 99 years at 900 per year. Government will pass back this land to the Order on condition that no development is carried out on it.

After working hard for more than three years on a new primary school for St Augustines College, MEPA last February turned down the application by five votes to four and wanted the extension to have two and not three floors as planned, making the whole project too small and costly to be viable.

On 9 February 2012 the Prime Minister was given a petition signed by parents after the students of the school, parents and teachers met near the War Monument in Floriana and walked to Castille.

Neighbours of the college had objecting to the project as the new building would block their view and devalue their property.

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Medical School becomes St Augustine Primary School

Mediocre or professional?

02 September 2012 | last updated at 11:12PM

A DOCTOR at a local public hospital recalls her medical school lecturer forewarning his charges about the challenges they would face when doing their housemanship. Housemen, he said, were like the "scum" of the department and in the organisational chart of the hospital, they would rank way below the amah (hospital orderly or attendant). These were certainly not the most encouraging of words to dish out to future doctors, but perhaps he was trying to prepare them for the real world of medical house officers.

For a long time now, housemen have always been viewed as an overworked and underpaid lot. They slogged for hours on end, especially when they were on call (sometimes up to 40 hours at a stretch), almost every other day, foregoing sleep and proper meals.

Coupled with that, there was the added pressure of having to deal with demanding superiors, difficult patients and even domineering ancillary staff. Little wonder that many a stressed and burnt-out houseman had gone into depression or called it quits after five long years in medical school.

To put things right, the Health Ministry introduced the new flexi-hour shift system last year in place of the on-call system to give these overworked housemen a breather. Many have hailed it as long overdue, but one year on, the question that is being asked is: are our housemen being given a better life at the expense of experience?

While they may now enjoy a better quality of life with the flexi-hour shift system, the limited number of hours spent on clinical work and their inadequate exposure to various disciplines of medicine will ultimately affect the quality healthcare that the country is aiming for.

Stories about inept housemen and their lack of knowledge, as related by senior doctors, are quite appalling. Some are said to be clueless on how to read a patient's blood pressure, let alone insert an intravenous line. To be fair, with medical schools churning out graduates by the thousands each year and with only 37 training hospitals to accommodate them, these housemen cannot be expected to get the thorough clinical work experience their predecessors benefited from.

But all is not lost if these housemen are passionate about their calling and abide by the Hippocratic Oath of continuing "with diligence to keep abreast of advances in medicine" by engaging in continuous professional development. For as long as housemen have no interest in what goes on beyond their "training hours", it will be a loss, not just for the medical profession, but for all Malaysians.

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Mediocre or professional?

Harvard Medical School is cited for mistreatment of lab animals

Harvard Medical School is cited

for mistreatment of lab animals

In less than two years, four monkeys have died in labs at Harvard Medical School, including one that was left in a cage as the cage went through a mechanical washer. The most recent death occurred this spring, when a cotton-top tamarin monkey died of thirst for lack of a water bottle.

In addition, 41 deer mice died in April at a Harvard facility after their water source was cut off.

The Department of Agriculture has given the medical school an official warning for violating the U.S. Animal Welfare Act.

When you see multiple incidents at the same facility over a period of time, thats when you realize that this is indicative of a system-wide problem, said Michael Budkie, executive director of Stop Animal Exploitation Now!

Harvard University made the nonprofit groups top-10 list of animal-welfare violators for the first half of 2012, along with Harvard Medical School. The two institutions have separate licenses from the USDA to use animals for research and testing.

The Animal Welfare Act, enforced by the USDAs Animal and Plant Health Inspection Service, or APHIS, requires labs to handle research animals as carefully as possible to prevent trauma, overheating, physical harm, behavioral stress or unnecessary discomfort.

APHIS also is investigating the death of five monkeys at the Harvard-affiliated New England Primate Research Center, said USDA spokesman David Sacks. The centers interim director, Frederick Wang, stepped down in March after the death of the tamarin monkey.

In March, Harvard Medical School Dean Jeffrey S. Flier ordered an independent review panel to evaluate the management and care of animals used in experiments. The panels recommendations included the appointment of a veterinarian and biosafety officer to oversee the primate center and the development of new approaches to its oversight process.

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Harvard Medical School is cited for mistreatment of lab animals

New Study in CHEST Validates the Cheetah NICOM® 100% Non-Invasive Method for Addressing One of the Most Difficult …

VANCOUVER, Wash., Sept. 4, 2012 /PRNewswire/ -- A new study led by Dr. Paul Marik, Professor and Division Chief of Pulmonary Critical Care at Eastern Virginia Medical School in Norfolk, VA was published this week in CHEST, the journal of the American College of Chest Physicians. The study confirmed the high accuracy of using the non-invasive NICOM technology to assess fluid status, one of the most prevalent and frequent challenges in critical care and emergency medicine.

Intravenous (IV) fluid administration has long been a cornerstone of treating patients in shock. In fact, early, guided fluid administration has been shown to lead to dramatic improvements in outcomes and survival of various conditions including sepsis, major surgery and trauma. However, multiple studies have shown that only approximately 50% of critical care patients are responsive to additional fluid. That is, in about half of patients, increased fluid will significantly improve their cardiac function (as measured by stroke volume); whereas in the other half, it will not. Furthermore, accumulating evidence suggests that both inadequate and excessive fluids are associated with poor outcomes. A method to determine volume responsiveness and dosing of fluid is important in the critical care setting; but historically many methods have been invasive, associated with catheter-line blood stream infections or bleeding, costly, and/or had unacceptable accuracy.

In this study, Dr. Marik and team confirmed the accuracy and effectiveness of Cheetah Medical's NICOM system, a 100% non-invasive hemodynamic monitoring system, to address the challenge of fluid management. Critical care patients suffering from sepsis, shock and other life-threatening conditions were monitored with the NICOM monitor and a passive leg raise (PLR) maneuver was performed. PLR induces a gravitational transfer of blood from the lower limbs towards the heart. If the NICOM monitor recorded a change in stroke volume index (SVI) of greater than 10%, the patient was considered fluid responsive. The results from the PLR with NICOM were then compared to results from an IV fluid bolus and carotid Doppler flow measurements. The PLR maneuver with NICOM monitoring had a sensitivity of 94% and a specificity of 100% for predicting volume responsiveness.

The conclusion of the study is, "Monitoring the hemodynamic response to a PLR maneuver using the NICOM provides an accurate method of assessing volume responsiveness in critically ill patients."

"As critical care physicians we understand that determining a patient's fluid status is essential to our ability to provide safe and effective treatments to our patients. Fluid optimization is the cornerstone of medical management in many of our patients, most notably those suffering from sepsis, trauma, acute kidney injury and those recovering from major surgical interventions," said Dr. Jordan Bonomo, Director, Division of Critical Care, Department of Emergency Medicine, University of Cincinnati College of Medicine. "This research further validates my experience in using NICOM monitoring, along with the PLR maneuver, in the management of critically ill patients."

"We are pleased with the study findings, which further validate our technology and complement previous studies that have come to similar conclusions," said Yoav Avidor, MD, CEO of Cheetah Medical. "We hope this study will encourage use of Cheetah's NICOM system in the management of critical care, emergency medicine and surgical patients. We believe that NICOM may enable hospitals to advance the quality of care for a large number of patients that are not benefiting from advanced hemodynamic monitoring and fluid optimization today."

About Cheetah Medical Cheetah Medical's NICOM Noninvasive Cardiac Output and Hemodynamic Monitoring System uses the company's proprietary BIOREACTANCE Technology to deliver continuous, accurate, noninvasive cardiac output (CO) and other vital hemodynamic monitoring parameters, useful for fluid management and drug titration. The system is FDA-cleared and CE Marked, and since its commercial launch in 2008 has been adopted by a growing number of clinicians worldwide. Cheetah Medical headquarters is located in Tel-Aviv, Israel and its United States headquarters is located in Vancouver, Washington. For more information, visit our website at http://www.cheetah-medical.com.

Reference: Marik PE, Levitov A, Young A, et al. The use of NICOM (Bioreactance) and Carotid Doppler to determine volume responsiveness and blood flow redistribution following passive leg raising in hemodynamically unstable patients. Chest. 2012. [Epub ahead of print]

Dr. Jordan Bonomo was not an investigator in this study and has no relevant financial interests to disclose.

For further information contact: Kristina Frey Cheetah Medical kristina@cheetah-medical.com 317-489-8922

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New Study in CHEST Validates the Cheetah NICOM® 100% Non-Invasive Method for Addressing One of the Most Difficult ...

Antibody prevents hepatitis C in animal model

Public release date: 30-Aug-2012 [ | E-mail | Share ]

Contact: Joseph Carey jcarey@txbiomed.org 210-258-9437 Texas Biomedical Research Institute

A monoclonal antibody developed by MassBiologics of the University of Massachusetts Medical School (UMMS) and tested in an animal model at the Texas Biomedical Research Institute, prevents infection by the hepatitis C virus (HCV).

Researchers found that the human monoclonal antibody targeting the virus protected chimpanzees from HCV infection in a dose-dependent manner in a study conducted at Texas Biomed's Southwest National Primate Research Center. Chimpanzees are the only species other than humans that can be infected by HCV and therefore the results from this study were critical in the development of the monoclonal antibody.

The new report by scientists from MassBiologics; Texas Biomed; the National Institutes of Health (NIH); and Merck Research Laboratories, and funded by MassBiologics and NIH, appears in the August 30th issue of PLoS Pathogens. Researchers had previously demonstrated that the monoclonal antibody, called HCV1, blocks HCV from infecting liver cells in laboratory tissue culture.

"This is an important preclinical proof-of-concept study demonstrating a high dose of neutralizing antibody can protect the liver from HCV infection using monoclonal antibodies in a study that was designed to mimic the transplantation setting," said study co-author Robert E. Lanford, Ph.D., of Texas Biomed.

"One can envision improving on these results with a cocktail of antibodies or by using this antibody with some of the newer antivirals currently in clinical trials. Infection of the new donor liver by residual virus in the patient is one of the major obstacles preventing a full recovery in these patients," Lanford added.

MassBiologics has been pursuing the development of HCV1 as a therapy for patients with end-stage liver disease undergoing liver transplantation as a result of HCV infection. HCV1 is a monoclonal antibody that binds to the surface of the HCV virus and blocks the ability of the virus to enter liver cells.

HCV damages the liver and is the leading indication for liver transplantation, diagnosed in about half of the 6,000 patients who receive liver transplants each year in the United States. According to the US Centers for Disease Control and Prevention (CDC), 3.2 million Americans are chronically infected with HCV and approximately 10,000 die annually of the disease. Globally, as many as 170 million people are estimated to suffer from HCV infection. The CDC recently recommended that everyone born from 1945 to 1965 should be screened for HCV regardless of whether they have known risk factors.

For patients with end-stage liver disease from HCV infection, liver transplantation is the only option. While it can be a life-saving treatment, transplantation does not cure the disease. In nearly all cases, the patient's new liver is eventually infected by HCV because the virus remains in the patient's bloodstream during surgery. The course of recurrent HCV disease is accelerated after transplantation and up to 20 percent of transplant patients develop cirrhosis within five years. Unfortunately, the standard antiviral drugs currently used to treat HCV prior to the onset of end-stage liver disease are poorly tolerated after liver transplantation, leaving these patients with few options.

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Antibody prevents hepatitis C in animal model

Antibody Prevents Hepatitis C Infection in Animal Model

Newswise A monoclonal antibody therapy developed by MassBiologics of the University of Massachusetts Medical School (UMMS) and tested in an animal model at the Texas Biomedical Research Institute, prevents infection by the hepatitis C virus (HCV).

Researchers found that the human monoclonal antibody targeting the virus protected chimpanzees from HCV infection in a dose-dependent manner in a study conducted at Texas Biomeds Southwest National Primate Research Center in San Antonio. Chimpanzees are the only species other than humans that can be infected by the hepatitis C virus and therefore the results from this study were critical in the development of the monoclonal antibody. The new report by scientists from MassBiologics; Texas Biomed; the National Institutes of Health (NIH); and Merck Research Laboratories, and funded by MassBiologics and NIH, appears in the August 30th issue of PLOS Pathogens. Researchers had previously demonstrated that the monoclonal antibody, called HCV1, blocks HCV from infecting liver cells in laboratory tissue culture.

This is an important proof-of-concept study demonstrating a high dose of neutralizing antibody can protect the liver from HCV infection using monoclonal antibodies in a study that was designed to mimic the transplantation setting, said study co-author Robert E. Lanford, Ph.D., of Texas Biomed.

One can envision improving on these results with a cocktail of antibodies or by using this antibody with some of the newer antivirals currently in clinical trials. Infection of the new donor liver by residual virus in the patient is one of the major obstacles preventing a full recovery in these patients, Lanford added.

MassBiologics has been pursuing the development of HCV1 as a therapy for patients with end-stage liver disease undergoing liver transplantation as a result of HCV infection. HCV1 is a monoclonal antibody that binds to the surface of the HCV virus and blocks the ability of the virus to enter liver cells.

HCV damages the liver and is the leading indication for liver transplantation, diagnosed in about half of the 6,000 patients who receive liver transplants each year in the United States. According to the US Centers for Disease Control and Prevention (CDC), 3.2 million Americans are chronically infected with HCV and approximately 10,000 die annually of the disease. Globally, as many as 170 million people are estimated to suffer from HCV infection. The CDC recently recommended that everyone born from 1945 to 1965 should be screened for HCV regardless of whether they have known risk factors.

For patients with end-stage liver disease from HCV infection, liver transplantation is the only option. While it can be a life-saving treatment, transplantation does not cure the disease. In nearly all cases, the patients new liver is eventually infected by HCV because the virus remains in the patients bloodstream during surgery. The course of recurrent HCV disease is accelerated after transplantation and up to 20 percent of transplant patients develop cirrhosis within five years. Unfortunately, the standard antiviral drugs currently used to treat HCV prior to the onset of end-stage liver disease are poorly tolerated after liver transplantation, leaving these patients with few options.

This research was supported in part by the Intramural Research Program of the National Institute of Allergy and Infectious Diseases at NIH. The chimpanzee studies performed at the Southwest National Primate Research Center were supported by the NIH primate center grant P51 RR13986 and the NIH facilities grants C06 RR 12087 and C06 RR016228.

___________________________________________________________________ About MassBiologics MassBiologics of the University of Massachusetts Medical School is the only publicly owned, non-profit FDA-licensed manufacturer of vaccines and other biologic products in the United States. The laboratory was established in 1894 by the state Board of Health to produce diphtheria antitoxin. Since that time, the focus at MassBiologics has been to improve public health through applied research, development and production of biologic products. In 1997, the Commonwealth of Massachusetts transferred MassBiologics operations from the Department of Public Health to UMass Medical School to maintain their public purpose, preserving their ability to compete in an increasingly competitive marketplace and to maximize their value to the Commonwealth.

About the University of Massachusetts Medical School The University of Massachusetts Medical School, one of the fastest growing academic health centers in the country, has built a reputation as a world-class research institution, consistently producing noteworthy advances in clinical and basic research. The Medical School attracts more than $250 million in research funding annually, 80 percent of which comes from federal funding sources. The mission of the Medical School is to advance the health and well-being of the people of the commonwealth and the world through pioneering education, research, public service and health care delivery with its clinical partner, UMass Memorial Health Care. For more information, visit http://www.umassmed.edu/.

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Antibody Prevents Hepatitis C Infection in Animal Model