Texas doctor, 28, dies of Covid: ‘She wore the same mask for weeks, if not months’ – The Guardian

It took Carrie Wanamaker several days to connect the face she saw on GoFundMe with the young woman she had met a few years before.

According to the fundraising site, Adeline Fagan, a 28-year-old resident OB-GYN, had developed a debilitating case of Covid-19 and was on a ventilator in Houston.

Scrolling through her phone, Wanamaker found the picture she took of Fagan in 2018, showing the fourth-year medical student at her side in the delivery room, beaming at Wanamakers pink, crying, minutes-old daughter. Fagan supported Wanamakers leg through the birth because the epidural paralyzed her below the waist, and they joked and laughed since Wanamaker felt loopy from the anesthesia.

I didnt expect my delivery to go that way, Wanamaker, a pediatric dentist in upstate New York, said. You always hear about it being the woman screaming and cursing at her husband, but it wasnt like that at all. We just had a really great time. She made it a really special experience for me.

Fagans funeral took place on Saturday.

The physician tested positive for the virus in early July and died on 19 September after spending over two months in hospital. She had worked in a Houston emergency department, and a family member says she reused personal protective equipment (PPE) day after day due to shortages.

Fagan is one of over 250 medical staff who died in southern and western hotspot states as the virus surged there over the summer, according to reporting by the Guardian and Kaiser Health News as part of Lost on the Frontline, a project to track every US healthcare worker death. In Texas, nine medical deaths in April soared to 33 in July, after Governor Greg Abbott hastily pushed to reopen the state for business and then reversed course.

Among the deceased healthcare workers who have so far been profiled in depth by the Lost on the Frontline team, about a dozen nationwide, including Fagan, were under the age of 30. The median age of death from Covid for medical staff is 57, compared to 78 in the general population. Around one-third of the deaths involved concerns over inadequate PPE. Protective equipment shortages are devastating for healthcare workers because they are at least three times more likely to become infected than the general population.

It kicked me in the gut, said Wanamaker. This is not what was supposed to happen. She was supposed to go out there and live her dreams and finally be able to enjoy her life after all these years of studying.

Fagan worked at a hospital called HCA Houston Healthcare West, and had moved to Texas in 2019 after completing medical school in Buffalo, New York, a few hours from her hometown of LaFayette.

She was the second of four sisters, all pursuing or considering careers in the medical field. Her younger sibling, Maureen, 23, said she dealt with patients in uncomfortable or embarrassing situations with grace, as she had observed when she accompanied her on two medical mission trips to Haiti. Addie was very much, Do you understand? Do you have other questions? I will go over this with you a million times if need be.

Maureen also mentioned Fagans comic side she was voted by her colleagues most likely to be found skipping and singing down the hall to a delivery and prone to rolling out hammy Scottish and English accents.

Fagan loved delivering babies, loved being part of the happy moment when a baby comes into the world, loved working with mothers, said Dori Marshall, associate dean at the University at Buffalo medical school. But she found living by herself in Houston lonely, and in February Maureen moved down to keep her company; she could just as easily prepare for her own medical school entrance exam in Texas.

It is unclear how Fagan contracted coronavirus, but to Maureen it seemed linked to her July rotation in the ER. HCA West is part of HCA Healthcare the countrys largest hospital chain and in recent months a national nurses union has complained of its willful violation of workplace safety protocols, including pushing infected staff to continue clocking in.

Amid national shortages, Maureen said her sister faced a particular challenge with PPE. Adeline had an N95 mask and had her name written on it, she said. Adeline wore the same N95 for weeks and weeks, if not months and months.

The CDC recommends that an N95 mask should be reused at most five times, unless a manufacturer says otherwise. HCA West said it would not comment specifically on Maureens allegations, but the facilitys chief medical officer, Dr Emily Sedgwick, said the hospitals policies did not involve constantly reusing masks.

Our protocol, based on CDC guidance, includes colleagues turning in their N95 masks at the conclusion of each shift, and receiving another mask at the beginning of their next shift. A spokesperson for HCA West, Selena Mejia, also said that hospital staff were heartbroken by Fagans death.

On 8 July, Fagan arrived home with body aches, a headache and a fever, and a Covid test came back positive. For a week the sisters quarantined, and Fagan, who had asthma, used her nebulizer. But her breathing difficulties persisted, and one afternoon Maureen noticed that her sisters lips were blue, and insisted they go to hospital.

For two weeks the hospital attempted to supplement Fagans failing lungs with oxygen. She grew so weak she wasnt able to hold her phone up or even keep her head upright. She was transferred to another hospital where she agreed to be put on a ventilator.

Less than a day later, she was hooked up to an ECMO device for a highly invasive treatment of last resort, in which blood is removed from the body via surgically implanted intravenous tubes, artificially oxygenated and then returned.

She lingered in this state through August, an experience documented on a blog by her software engineer father, Brant, who arrived in Houston with her mother, Mary Jane, a retired special education teacher, even though they were not allowed to visit Fagan.

The medical team tried to wean her off the machines and the nine sedatives she was at one point receiving, but as she emerged from unconsciousness she became anxious, and was put back under to stop her from pulling out the tubes snaking into her body. She was able to respond to instructions to wiggle her toes. A nurse told Brant she might be suffering from ICU psychosis, a delirium caused by a prolonged stay in intensive care.

The family tried to speak with her daily. The nurse told us that they have seen Adelines eyes tear up after we have been talking to her on the phone, Brant wrote. So it must be having some impact.

On 15 September, her parents were at last permitted to visit. I do not think we were prepared for what we saw, in person, when we entered her room, he wrote. Occasionally, Adeline would try to respond, shake her head or mouth a word or two. But her stare was glassy and you were not sure if she was in there.

It was too much for him. Being the softy that cannot stand it when one of my girls is hurting, [I] commenced to get light-headed and pass out.

Finally, on 17 September, it seemed Fagan was turning a corner. Still partly sedated, she was nevertheless able to sit up without support. She mouthed the words to a song, being unable to sing because a tracheostomy prevented air passing over her vocal cords.

The next day, the ECMO tubes were removed. The day after that, Brant made his last post.

His daughter had suffered a massive brain haemorrhage, possibly because her vascular system had been weakened by the virus. Patients on ECMO also take high doses of blood thinners to prevent clots.

A neurosurgeon said that even on the remote chance Fagan survived surgery, she would be profoundly brain damaged.

We spent the remaining minutes hugging, comforting and talking to Adeline, Brant wrote.

And then the world stopped

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Texas doctor, 28, dies of Covid: 'She wore the same mask for weeks, if not months' - The Guardian

Experimental COVID-19 Treatment Given To President Trump Part of Study At U of M Medical School – FOX 21 Online

This study is also being conduction nationally, which will enroll about 2,000 people.

DULUTH, Minn. The experimental treatment recently given to President Donald Trump for his diagnosis with COVID-19 will soon be part of a study being conducted at the University of Minnesota Medical School.

The particular drug treatment is made up of two identical antibodies, which are created in a lab.

The antibodies are expected to bind to the virus to help prevent it from attacking other cells in the body.

The U of M Medical School study will test the cocktail on people who have no symptoms, but have come in contact with people who were positive for COVID-19.

These are people we know have been exposed and are at higher risk of getting sick, but arent sick yet. What we are hoping to find out in my study is whether we can prevent them from becoming ill, said Anne-Marie Leuke, an assistant professor of infectious diseases and international medicine at the U of M Medical School.

The study is in partnership with a New York-based pharmaceutical company, which created the treatment.

The U of M Medical School has yet to start the trial, but plans to enroll about 100 people.

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Experimental COVID-19 Treatment Given To President Trump Part of Study At U of M Medical School - FOX 21 Online

Projects Awarded $3.3 Million by Frankel Innovation Initiative – University of Michigan Health System News

Fast Forward Medical Innovation (FFMI), a unit of the Medical School Office of Research, has awarded a combined $3.3 million in funding to four biomedical research projects in the inaugural round of the Frankel Innovation Initiative - a $20 million gift from the Maxine and Stuart Frankel Foundation to support the research and development of life-saving therapies at Michigan Medicine, in collaboration with other institutions.

The winning projects are U-M faculty-led, cover a range of disciplines, and have the potential for rapid clinical application and groundbreaking impact.

The projects focus on biomedical innovations that could quickly advance cutting-edge therapies and bring novel approaches to improving health into the hands of clinicians and scientists. Funded projects include:

Researchers presented their proposals to the Frankels and a Scientific Advisory Committee of world-renowned scientists and technology development professionals external to U-M.

We were extremely impressed with the high-caliber projects presented at the Frankel Innovation Initiative selection meeting, says Thomas F. Bumol, Ph.D., Chair of the Scientific Advisory Committee, Executive Vice President of the Allen Institute, and Director of the Allen Institute for Immunology in Seattle. U-M is a leader in translational medicine and at the forefront of biomedical innovation. We believe the winning projects possess the potential to have a tremendous impact on health and patient care around the world.

In addition to providing their expertise and guidance to the Frankel investigators, the committee will leverage their combined experience to harness the creative ingenuity of the investigators and help direct the translation from cutting-edge innovation to life-saving medical practice.

The Frankel Innovation Initiative is designed to build on best practices of the standout programs developed at U-M and other top institutions, and capitalizes on U-Ms extensive biomedical research enterprise as the top public university in research spending in the United States. The $20 million gift will be used to fund four to seven projects annually, with each project receiving between $250,000 $1 million.

This very generous gift from the Frankels will take these four innovative projects to the next level, says Marschall S. Runge, M.D., Ph.D. The foresight and funding of this initiative will provide the critical support needed for these investigators to quickly move their innovations in areas of great patient need.

The Initiative is administered by Fast Forward Medical Innovation, a group at Michigan Medicine that has the proven expertise and unique resources to work with faculty to bring together biomedical innovation and entrepreneurship and achieve life-saving results.

FFMI offers resources and support to world-class biomedical researchers at the university and across the state. This unit at U-M provides groundbreaking funding programs, dynamic educational offerings, and deep industry connections that help biomedical researchers navigate the road to successful innovation and commercialization, with the ultimate goal of positively impacting human health.For more information about FFMI,click here.

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Projects Awarded $3.3 Million by Frankel Innovation Initiative - University of Michigan Health System News

U of M research team hopes to develop an implantable device to treat mental illness thanks to a $6.6 million grant – MinnPost

Implanted medical devices can be used to treat a number of medical conditions, including regulating heart function or delivering electrical stimulation to targeted areas of the brain to treat essential tremors caused by Parkinsons disease. A new implantable device, to be designed and developed by scientists at the University of Minnesota Medical School, may be able to help treat common but serious mental illnesses like depression and PTSD.

A team of researchers, led by Alik Widge, M.D., Ph.D., assistant professor in the Universitys Department of Psychiatry and Behavioral Sciences, has been awarded a $6.6 million grant from the National Institute of Mental Health (NIMH) to develop the device, which would use electrical impulses to help misfiring brain rhythms fall into synchrony.

In a departure from the pace of typical academic research, this team which includes Widge; Greg Molnar, Ph.D., a medical device expert and associate professor in the Universitys Department of Neurosurgery; and Mahsa Shoaran, Ph.D., of the Swiss Federal Institute of Technology in Lausanne, Switzerland has put the implant project on the fast track. They hope to have a device that is ready for first in-human use in as little as six years.

The size of the grant points to the projects promise, Widge said: The National Institute of Mental Health doesnt normally give out this kind of money. $6.6 million is a large grant for still a relatively junior professor.

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The grant, Widge said, is a vote of confidence for his team, which includes clinicians who understand the problem and an expert with deep background making and bringing to market next-gen medical devices. And, he added, the fact that the medical school is located in the Twin Cities gives his project an edge: We are the Silicon Valley of implantable medical devices.

Dr. Alik Widge

When Widge approached him with his idea, Molnar was immediately enthusiastic about its prospects.

Its a big deal, he said. It is the first grant Ive seen at the University that is truly focused on translation. This is not pie-in-the-sky long-horizon academic research, Molnar added. The end result of this project will be a device that has the potential to change the way mental illness is treated. The deliverable is going to be a working first-in-human-ready closed-loop deep-brain stimulation system. Thats impressive.

The technology for treating brain disease with implantable devices already exists: For many years, for instance, people with Parkinsons disease have been treating the debilitating tremors and other symptoms associated with the disease with a device called a neurostimulator that delivers electrical stimulation to areas of the nervous system that control movement, blocking abnormal electrical signals.

A Parkinsons neurostimulator works much like a heart pacemaker. Widge explained that his device, while it will be able to use much of the hardware designed for other implantable devices, will require specific custom electronics to work on a different, more targeted level.

This is a new mechanism of action different from anything on the market, he said. This is something that is designed to get at the biology of mental illness in a way that wasnt possible before.

Widge and his colleagues see mental illness largely as a physical disease of the brain that can be treated by altering the way different parts of the brain communicate with each other.

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Most mental illness addiction, PTSD, depression, anxiety, OCD all of these conditions in different ways are caused by breakdowns or in some cases too much communication between certain parts of the brain in certain sub-networks, he said. His teams device will use targeted electrical stimulation to help build healthy connections between different areas of the brain.

Widge likes to use computer metaphors to explain his device. If you have a program on your computer or phone that goes a little bit rogue, it cant let go of whatever resource it is using, he said. You get that spinning beach ball and the whole system blocks up. If you can just fix that one thing thats causing the problem, if we can close that one small program and make a little tweak, the whole system can get back into alignment and function better.

By taking this direct, physical approach, Widges device has the potential to upend the way mental illness is treated.

Greg Molnar

The U of Ms proposed device will use existing implantable device technology, but will require unique custom electronics to deliver targeted electrical impulses to the brain, Widge said.

Deep-brain stimulation hardware that was developed to treat Parkinsons disease cant do what we need it to do. It wasnt designed for that. It was built off a rewired cardiac pacemaker. We have the stimulation hardware, but we dont have the right signal processing yet.

His team will be involved in developing custom circuitry to precisely time stimulation relative to ongoing brain activity.

If the brain rhythms are in synch, one area is getting ready to fire as the volume of information comes in from the first, Widge explained, switching mid-stream to a sports metaphor. Think about the receiver or outfielder who knows when the ball is going to be coming to him and is standing there ready to catch it. The catch is effortless and they are right there where they need to be. Thats what brain synchrony does.

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While Widge is confident that mental illness can be treated with implantable electrical stimulation, he credits Molnar with helping him understand that his project could be developed and delivered in record time.

Widge had been working in an animal lab for years, experimenting with stimulation patterns that can achieve the kind of communication between brain networks that is needed for his device. One day, he was talking to Molnar, explaining that he knows his device can work in rats but he didnt know how to take the next step of getting it to work in humans.

Molnar, with his deep background working in the implantable device industry and consulting with Minnesota companies specializing in developing the technology, was enthusiastic about Widges idea. He told Widge, whod been lured to the U of M from Harvard and MIT, that Minnesota was the perfect place to see his project through to completion.

Greg said, We have four contract medical device manufacturers in the Twin Cities alone, Widge recalled. He explained that in our ecosystem in this state, what weve got is a set of companies that have the individual parts of an implantable neurostimulator on their shelves ready to mix and match. This is where the Only in Minnesota story comes in.

Once Widge and his colleagues develop the custom electronics needed for their device, Molnar explained, theyll have their pick of medical device manufacturers primed to take the next step.

All these companies do is wait for someone to come up to them and say, I have a new medical device idea. I need a prototype made, Widge said. Once we build that one chip that runs the device, the rest is all available off the shelf. We just need to pick the right manufacturing partner to integrate our innovation with what they know how to do up to FDA standards.

Support from the University of Minnesotas MnDRIVE initiative aimed at boosting academic research and development in the states medical technology industry also gives Widge and Molnar hope that their device can be developed and tested in a relatively short period of time.

That kind of support, Widge said, is why I moved here. I was at Harvard and MIT before I came here, but they could not do what we can do here in Minnesota. This would not have happened if I had stayed in Boston.

That kind of overwhelming support for research, Molnar added, will help the team move their research to practical application in record time.

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This isnt your classic, Lets do this for five years, more research is needed, academic project, he said. This is taking discovery and literally, with my expertise, putting it into hardware.

At Medtronic, Molnar said, We dealt in reality. We wanted to make a product. With this project, the opportunity for collaboration with academia and industry is going to make this grant real.

Widge said that having Molnar on his team makes him feel that an accelerated timeline for his devices development is achievable. At the end of this grant I think well be ready for the animal test that will make it ready for the first in-human in five years. Thats warp speed for the medical device industry.

Widges optimistic clinician hat tells him that odds are the first version of the device the team builds will work. But that process will take a few years. You have to first test it in a pig or a sheep, but then it would be ready for human use, he said. My pessimistic research-engineer hat says, Nothing you build will work the first time. You will need to re-build several versions.

That said, Widge remains optimistic that this device could be ready for human use in record time. Im assuming that in six or seven years we will be doing pilot human clinical trials. This is something thats needed by so many people, so I am thrilled to think that it could become a reality in a relatively short time.

A new approach to therapy for people struggling with mental illness is a big, unmet need, Molnar said, and because of this he sees many possible uses for the device going forward.

In the future, he explained, This device will be used for treating depression and all the spectrum of symptoms of mental illness. This will have a huge impact on the quality of life for millions of people.

One group of people who could benefit from his device are those suffering from PTSD, Widge said. In people with PTSD, he explained, there is a part of the brain called the amygdala that is involved with fear and emotion. The prefrontal cortex provides the context. In PTSD, signals from the prefrontal cortex dont get through to the amygdala regardless of context. What we can do with this device is restore that communication, get those two reactions to work together and do what theyre supposed to do.

While the device will help put brain communication back into synch for people suffering from a range of mental illnesses, it will not be a one-and-done therapy. People with the device will still likely need to work with a psychotherapist to understand how best to respond to stress or life change, Widge said: Our system will have to combine with certain forms of talk therapy.

And just like any other implantable device, ongoing care is needed to help patients heal.

This is no different than any other implantable device, Widge said. If you get a knee replacement you will get 3-6 months of physical therapy to help you learn how to walk and strengthen those muscles. Its the same with our device.

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U of M research team hopes to develop an implantable device to treat mental illness thanks to a $6.6 million grant - MinnPost

The intersection of climate and health: Stanford group works for change – Scope

"Don't worry, the grownups have it figured out."

I was in third grade and terrified. My teacher was teaching us about global warming -- wildfires, droughts, hurricanes, floods -- the destabilization of our ecosystem, the destruction of our future.

I was scared. But I calmed down: "It's OK, the adults will solve it."

Fast-forward to junior year of college. I saw environmental protections torn down, and the United States withdraw from the Paris climate agreement. My parents told me about the red and gray wildfire smoke coloring the Bay Area sky.

The grownups hadn't figured it out. Then who would?

I knew I had to act. In college, I spent thousands of hours organizing with fellow students and stakeholders to design and advocate for climate policy in New Jersey.

When I arrived at Stanford for medical school last year, I wasn't sure at first how to continue my environmental work, but I knew it was important. The environment is health. Ask any doctor who sees their asthmatic patient choking on wildfire smoke.

Last September, while we were studying for our molecular mechanisms final, the Global Climate Strikes happened. My classmates - Adary Zhang, Santiago Sanchez, Ashley Jowell -- and I put together a lunch talk about climate and health.

We talked about the health effects of air pollution, extreme heat, floods. We talked about how environmental disasters are unjust -- that they always hit low-income communities hardest, even if they contributed least to the problem. And we talked about the problem of greenhouse gas emissions and how we cannot reach our climate goals if the health care sector doesn't cut its share.

We decided to form Stanford Climate and Health. We are a group of Stanford medical, physician assistant, graduate, and undergraduate students; residents; staff; and faculty who are all passionate about the intersection of climate and health.

One of our goals is to find workable ways for hospitals and health systems to reduce their emissions and build resilience toward worsening disasters, such as extreme heat, wildfires and air pollution. Taken together, this is known as "climate-smart health care."

We also need to learn more about the health effects of climate change -- the impacts on the lung, the heart, the kidney and the skin; on children, women, and the elderly; on low-income communities and people of color.

So far, we've worked with medical course directors to weave climate change into our curriculum, and we're working on deploying safe and cost-effective reusable gowns at Stanford Health Care. We are also advocating in our professional societies, including the California Medical Association and American Academy of Physician Assistants, to make climate change a priority issue for patient health. We've additionally supported a climate change vulnerability assessment for Santa Clara County.

Our first major event is coming up on Sept. 25. The NorCal Symposium on Climate and Pandemic Resilience in Healthcare is a virtual gathering, co-organized with the University of California, San Francisco, with the aim of inspiring our community to take action toward more sustainable health care.

Speakers include Cheryl Holder, MD, founder of Florida Clinicians for Climate Action and a physician leader combating climate change and other health inequities in underserved communities.Dean Lloyd Minor, MD, and David Entwistle, president and CEO of Stanford Health Care, also will be there, along with leaders from UCSF and the National Resources Defense Council.

We'll have sessions on emissions, disaster resilience, community partnerships, advocacy, food systems, and medical curriculum. We'll welcome sustainability leaders, health professionals, students and community partners from all backgrounds; and we'll encourage them to work with us to take action toward a just and sustainable future.

Because that's how change happens. It takes grown-ups and young people,deans and students, activists and innovators, front-line communities and environmental advocates, and every kind of health professional, working together as a community, to create a world where third graders don't have to worry anymore.

Jonathan Luis a second-year medical student at Stanford who is passionate about addressing climate change and its health impacts. He is a co-leader of Stanford Climate and Health, along withAshley Jowell, Navami JainandNatalie Baker.You can reach them atstanfordclimateandhealth@gmail.com

Top photo by MILKOV. Middle photo by Jonathan Lu.

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The intersection of climate and health: Stanford group works for change - Scope

Team assessing if dual-antibody injection prevents COVID-19 illness – Newswise

Newswise A combination antibody treatment for preventing COVID-19 illness in individuals who have had sustained exposure to someone with the virus is being studied by researchers at The University of Texas Health Science Center at Houston (UTHealth). The clinical trial is enrolling patients at Harris Health Systems Lyndon B. Johnson Hospital.

The Phase III, randomized, double-blinded, placebo-controlled trial will help researchers determine if the laboratory-made dual-antibody treatment, REGN-COV2, can prevent SARS-CoV-2 infection in individuals who share a home with someone with a confirmed infection.

If this trial demonstrates that this treatment is effective, it could be used in various settings where exposure risk is heightened, such as health care, airlines, meatpacking factories, nursing homes, and among first responders, saidRoberto C. Arduino, MD, the studys lead investigator and professor of infectious disease withMcGovern Medical Schoolat UTHealth. It is crucial that we discover treatment options that can not only prevent severe illness, but also stop the spread of COVID-19 within our communities.

The study team is seeking to enroll asymptomatic individuals who have had at least 48 hours of sustained exposure to a person with a confirmed SARS-CoV-2 infection, known as an index case. Participants must be randomized within 96 hours of the index cases diagnosis. Trial participants must live in the same household as the index case patient for 29 days during the study.

REGN-COV2 is a combination of two monoclonal (laboratory-made) antibodies that target two different sites of the spike protein found on the surface of SARS-CoV-2, the virus that causes COVID-19. Antibodies are proteins created by the immune system to fight a pathogen or infection. The targeted surface spike protein gives the virus a crown-like appearance and allows it to attach to and enter cells.

The REGN-COV2 antibody cocktail is a combination of antibodies originally isolated from patients who have recovered from COVID-19 and produced by mice that have been genetically modified to have human immune systems.

The study period will last 32 weeks. On day one of enrollment, patients will receive four subcutaneous injections of either the trial agent or a placebo. This treatment strategy is known as passive immunization, and is the current strategy used for tetanus, rabies, hepatitis B, and herpes zoster exposures. Participants will be tested for COVID-19 weekly during the first month they are enrolled.

Co-investigators from McGovern Medical School includeKaren J. Vigil, MD, an associate professor of infectious disease and medical director of infection prevention for UT Physicians outpatient operations; andSarah Duong, MD, a general internal medicine physician. Jonatan Gioia, MD, is the program manager.

Regeneron Pharmaceuticals is sponsoring the clinical trial. For more information, visitClinicalTrials.gov.

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Team assessing if dual-antibody injection prevents COVID-19 illness - Newswise

Luke Schafer: Prioritizing Medical School Over the Games – Morning Chalk Up

Luke Schafer: Prioritizing Medical School Over the Games | Morning Chalk Up

Photo Credit: Athletes Eye (instagram.com/athleteseyephotography)

Unassuming.

That is the word best used to describe Luke Schafer and hes totally fine with that. The 2020 CrossFit Games qualifier has other items to worry about right now the Games however are not at the top of that list. Since early July, Schafer has been enrolled in medical school at Still University in Kirksville, Missouri. That has kept him busy and has become his main priority. But nevertheless he has committed to participating in the online portion of the Games on September 18-19, you just wont hear much from him about it.

Remind me: Schafer is not a Games rookie he has made two appearances as a team member in 2015 and then again at last years Games. At last years Games he helped OC3 Black to a fourth place finish. Despite his Games experience on a team he has also competed as an individual including the 2018 and 2018 Central Regionals, finishing eighth and 11th respectively. Altogether he has five Regional appearances including three on a team.

During the 2019 season he competed in four Sanctionals including two as an individual. He started his season with an 18th place at the star-studded Dubai CrossFit Championship before placing seventh at the Granite Games.

For the second-straight year Schafer finished within the top-50 in the Open. He recorded a career-best placing of 46th, a three-spot jump from his 2019 finish.

Enter 2020: Schafer earned his ticket to this years Games after taking second place at the CrossFit Mayhem Classic. He received the invite after Chandler Smith qualified through the Open giving Schafer the backfill spot. Schaefer recorded three top-three finishes at the competition finishing 14 points behind Smith.

Path to the Live Five:Schafer admitted that his training has taken a backseat since starting medical school.

Schafer thrives in grunt-work events, longer workouts and chippers. Workouts that also incorporate running in them is also a strength of his. Schafer may get his wish as running will be incorporated into one of the workouts of the online stage of the Games.

His top finishes at the Mayhem Classicshow that as he finished second in the grueling five-mile ruck-run with a time of 51:00. His other runner-up finish at the Mayhem Classic was in a chipper that included burpee box get-overs, assault bike, GHD sit-ups and bar muscle-ups.

In this years Open his best event was 20.5 where he placed 26th in a workout that featured 40 muscle-ups, 80-cal. Row and 120 wall-balls.

Where Schafer has struggled in the past has been in events that test strength or have heavy loads.

In 20.4 he placed 207th as he just finished under the 20-minute time cap of a workout that ended with five clean and jerks at 315 LBs which is his listed 1-rep max.

Schafer has also historically struggled with workouts that require being upside down. His worst finish at the Mayhem Classic was the 18th in event three, a couplet which included four rounds of 100-feet handstand walks.

In the Open, his worst event was 20.3 where he finished 241st worldwide. 20.3 included handstand pushups and walks along with deadlifts.

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Luke Schafer: Prioritizing Medical School Over the Games - Morning Chalk Up

Med School Student Serves as Lead Author of Alzheimer’s Research Article – UNLV NewsCenter

UNLV School of Medicine third-year student Justin Bauzon was in a psychology course at Las Vegas Advanced Technologies Academy when he became absolutely infatuated with the brain, the organ Nobel laureate James Watson, co-discoverer of DNAs structure, called the most complex thing we have yet discovered in our universe.

Bauzons fascination wasnt just a high school passing fancy his interest continued to grow as an undergraduate at the University of California, Berkeley, where he majored in neurobiology, the study of the nervous system and the workings of the brain.

Each year, I took every college course I could sign up for that was neuro-related, he said. I was fascinated by the brains complexity and how it could determine the very behaviors and interactions that make us human. I found the idea that there was much we didnt know about the brain so perplexing the lack of truly curative interventions for many brain-related diseases like Alzheimers attests to how much we still have to learn. I saw this gap in knowledge as an opportunity where I could contribute and really make a difference.

With that background in mind, the fact that Bauzon recently became the lead author of an important research articlein the highly respected, peer-reviewed Alzheimers Research & Therapy journal doesnt seem at all unlikely. His teams publicationexamines whether drugs used for one purpose can also be an effective treatment for Alzheimers, a progressive and fatal brain disorder with a long goodbye, one that often reduces sufferers to quarrelsome infancy.

Justin Bauzons paper shows how many repurposed drugs are being tested in Alzheimers disease and where the drugs came from in terms of conditions for which they are already approved, said Dr. Jeffrey Cummings, the former medical director of the Cleveland Clinic Lou Ruvo Center for Brain Health in Las Vegas and now director of the Chambers-Grundy Center for Transformative Neuroscience in the UNLV department of brain health. This is an important contribution to understanding Alzheimers drug development and will encourage others to use the repurposing strategy, ultimately resulting in better treatments for patients.

Trials for the repurposing or repositioning of drugs are not unusual. Because they have been previously optimized for efficacy, safety, and bioavailability, considerable investments in research and development can be compressed through repurposing. It is also not unusual for one drug to be effective for more than one disease. Gabapentin, for instance, was originally developed for treating epilepsy and is now an effective pain-killer. Sildenafil, originally developed for treating high blood pressure, is today more often used to treat erectile dysfunction. Drugs created to combat one type of cancer have been found to be effective against other types.

Millions of dollars can be shaved off by bypassing some early trials that drugs go through, Bauzon noted.

Data, he said, is too preliminary to conclude which, if any, of the 58 drugs now in different stages of clinical trials for repurposing will ever be designated as a treatment for Alzheimers. The best that can be said is that some seem to have more potential than others, he said.

Bauzon doubts any one pill will ever be the cure-all for the disease that now affects more than 5 million Americans, robbing people of memory. He believes many therapeutics will be used to mitigate the disease that Americans now fear even more than cancer or heart disease.

Dr. Dale Netski, the UNLV School of Medicine director of medical student research, called Bauzons first-author publication in a very competitive peer-reviewed journal an amazing accomplishment for a third-year medical student. I hope that Justin will continue to work hard to close knowledge gaps, leading to innovative therapeutic approaches to combat Alzheimers.

It was early last summer that Bauzon began what became a year-long study that he carried out with the help of Cummings and former Ruvo Center pharmacist Garam Lee. Given his fascination with the brain, it isnt surprising that Bauzon reached out about possible projects to Cummings, one of the worlds top Alzheimers researchers. In 2014 Cummings released a study that found between 2002-12, the failure rate for drugs developed specifically to treat the disease was a woeful 99.6 percent.

Cummings told Bauzon a drug repurposing study could be of real value.

I found it remarkable how humble Dr. Cummings is, Bauzon said. He always listened to my questions, answered them fully. I always felt that he was accessible.

Following his 2015 graduation from UC Berkeley, Bauzon did not immediately apply to medical school. He did administrative work for Las Vegas bariatric surgeon Darren Soong, volunteered at the Ruvo Center, and worked as a research assistant with Rochelle Hines, an assistant professor of psychology. She specialized in neurodevelopmental research, and it was especially thanks to her passion, and limitless patience that I was driven to pursue research in medical school. Soong, he said, helped convince him that UNLVs medical school, with a curriculum designed to help the community, would be the best place for him to pursue his medical education.

Bauzons parents his father is a family physician and his mother a neonatal nurse who decided to concentrate on the raising of her children immigrated to the U.S. from the Philippines in the 70s. Bauzons family moved to Las Vegas from California when he was 10.

Bauzon said his mothers decision to design an at-home after-school curriculum that involved science experiments and regular creative writing exercises has had much to do with his seemingly insatiable appetite for learning.

Learning became fun, he said. I was very fortunate to have a mother who always made it something I looked forward to.

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Med School Student Serves as Lead Author of Alzheimer's Research Article - UNLV NewsCenter

6 Medical Schools to Consider in 2021 – University Herald

Medical schools seem like they are a dime a dozen. There are so many, but the ones that stand out are the ones most people can name from the Ivy League schools. The trouble is, most people cannot afford an Ivy League medical degree. If you are trying to find a renowned school from which to achieve a medical degree while not going so far into debt, there are six other really good schools worth your consideration.

Along with the easy price tag, the American University of the Caribbean School of Medicine based in Sint Maarten gives you the perfect environment to learn and play. When you need a break, you are right in the heart of Caribbean tourist territory. When you have to work, you are making a difference in the lives of native Caribbeans who do not have access to high-quality healthcare.

Many Russian universities of medicine are world-renowned too. One of those, the Russian State Medical University, is well over a hundred years old and offers a variety of specialized medical degrees. The cost of attendance is most agreeable if you can speak Russian and don't mind living there for three years.

This is the leading medical school in Singapore, and one of the most easily identified medical schools in the whole world. The price tag ranks low after several American and British medical schools in an international medical school list. If you love Asian culture and want to get on board with advanced techniques in medicine and research while avoiding heavy six-figure tuition bills, this university may be for you.

A unique college located on the coastline of Grenada, West Indies accepts students from around the globe. A shared arrangement between the U.S. and Great Britain makes it possible to afford an education here. They have an exceptionally high pass rate and post-graduation employment rate too.

King's College London is one of the most premier universities in Great Britain. It has been training physicians for almost two hundred years. Famous doctors, like Lister, the father of modern antisepsis, are synonymous with King's College. Enjoy everything life in London offers along with your medical education at a very affordable price.

Regardless of where you come from, your school fees are very close in cost at this Parisian medical school. They will be elevated slightly for U.S. students this year, but considering how low these fees are already, a slight elevation in fees is really nothing by comparison. This is one of the most prestigious French medical schools in the country and around the globe.

Choosing a medical school that has notoriety is great, but also consider the location. Where would you like to study? Are you ready to pay for room and board at a school in another country? As you consider each of the above options, don't forget to consider housing expenses in your decision.

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Medical students to return to school, ending collective action – The Korea Herald

Medical students have taken a leave of absence in protest of the government's plan to increase admission quotas at medical schools. Meanwhile, fourth-year students who have been boycotting the state licensing exam also said Sunday they will put on hold their collective action.

The Korean Medical Student Association representing some 20,000 students said Monday its junior members, excluding the fourth year, will return to school after putting the issue to a vote.

The government, however, reiterated its earlier stance that it will not allow senior medical students to take the medical licensing exam. Earlier, the government said public opinion is still overwhelmingly negative toward giving an extra chance to students who withdrew their applications.

"Medical students voluntarily refused to take the exam," Sohn Young-rae, spokesperson for the Ministry of Health and Welfare, said in a press briefing. "There is no need for an additional exam when test-takers are refusing the exam of their own free will."

As trainee doctors returned to work after weeks of a strike over the government's policy, the medical students' collective action has served as a lingering source of tension between the government and the medical sector over the proposed reform plan.

Doctors and the government have been at odds over whether to give senior medical students another opportunity to take the licensing exam.

Doctors insisted students be allowed to take the test even if they did not register before the deadline, while the government has rejected such a step.

The government's plan to expand the number of medical students by 4,000 over the next 10 years and open a new public medical school sparked tensions within the medical sector.

Thousands of trainee doctors staged a strike for 18 days starting in mid-August over the policy.

A group of doctors and the ruling party agreed in early September to end a nationwide walkout on concerns that the prolonged collective action could disrupt the health care system amid the new coronavirus outbreak.

In response to the deal, the government backed down and promised to suspend the medical reform plan in early September. (Yonhap)

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Northern medical school on the newcomers recruiting trail – Northern Ontario Business

Northern Ontario School of Medicine, Lakehead University researchers receive $330K in immigration research grants

Government research involving the Northern Ontario School of Medicine (NOSM) and Lakehead University is looking to find ways to bring more immigrants to Northern Ontario to work in primary health care.

The Ontario Human Capital Research and Innovation Fund (OHCRIF) is providing more than $330,000 to Lakehead and NOSM.

The study aims to build a consensus model of community-specific needs, recognizing that primary care in the North often includes emergency department coverage and in-patient care.

The team will investigate how the workforce of Northern Ontario is evolving differently from that of the rest of Ontario, and will examine models of planning for workforce sustainability involving different demographics and different conditions of health-care demand, said a news release from Lakehead.

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The funding includes $250,000 from OHCRIF going to researchers Dr. Erin Cameron, Dr. Diana Uranijik, Dr. Brianne Wood and John Hogenbirk.

Their study, Working models for human capital planning in Northern Ontario: a model for the primary healthcare workforce, will focus on human capital planning in Northern Ontarios primary care sector, said the release.

It is an ambitious project, but study findings could help inform provincial agencies, workforce planning boards, communities, employers such as hospitals, primary-care providers, health-care education institutions, Ontario Health Teams, and others to better plan for and respond to community and employer needs within a primary health-care setting," said Cameron, an assistant professor at NOSM.

Additional funding of $83,093 has been granted to a team of Lakehead researchers led by Dr. Kathy Sanderson for research that examines how community and organizational welcoming affects the retention and recruitment of new immigrants.

Sanderson and her team from the Faculty of Business are looking for local employers and community leaders to get involved and share their experience in this area. To find out how to participate, visit welcomeNWO.ca.

Both projects are funded in part by the Government of Canada and the Government of Ontario.

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Meet the top doctors leading IU’s COVID-19 health, safety efforts – IU Newsroom

As home to the largest medical school in the country, as well as leading voices in medical research and clinical care, Indiana University didn't have to look far for expert guidance in response to the COVID-19 pandemic.

At the request of IU President Michael A. McRobbie, the university formed its Medical Response Team for COVID-19 over the summer to plan and implement ongoing health and safety strategies to protect students, faculty and staff and to help campus leadership make decisions informed by expert analysis and knowledge of clinical care and public health.

With the fall semester now in full swing, the team meets daily and regularly reviews data and reports on a multitude of factors -- including testing results, contact tracing efficiency and response, outbreak mitigation efforts, and logistical concerns -- that help IU take swift action to limit the spread of COVID-19 among students, faculty and staff.

"All decisions are viewed through the lens of a composite of metrics that attempt to understand the internal burden of disease, the external burden in the surrounding communities, how effective we are at controlling the virus locally and the availability of resources to keep the IU community safe," said Dr. Cole Beeler, an IU School of Medicine faculty member and one of three physician leaders of the IU Medical Response Team. "We are working every day to make sure IU can continue to provide the education and research services that our students and state rely on us for as safely as possible."

The overall work of the Medical Response Team is divided into three areas: symptomatic testing, contact tracing and mitigation testing. Each area has its own leader and core team members responsible for coordinating COVID-19 prevention and mitigation efforts across all campuses.

Beeler is the director of symptomatic testing for the IU Medical Response Team. He is also an assistant professor of clinical medicine in the Division of Infectious Diseases at the IU School of Medicine and medical director of infection prevention at IU Health University Hospital in Indianapolis, where he cares for patients and has a clinic.

Beeler, who grew up in Indiana, completed his college, medical school, residency and fellowship training at IU.

Dr. Adrian Gardner is the director of contact tracing for the IU Medical Response Team. He is also associate dean for global health at the IU School of Medicine, as well as director of the IU Center for Global Health and executive director of the Academic Model Providing Access to Healthcare Consortium of North American academic health centers.

Gardner earned his medical degree from Brown University, completed a fellowship in infectious diseases at Beth Israel Deaconess Medical Center in Boston, and earned a Master of Public Health from the Harvard School of Public Health.

He joined IU in 2012 as the executive field director of the AMPATH Consortium and was based full time in Eldoret, Kenya, for seven years. During his time in this role, Gardner worked closely with Kenyan program leadership to make strategic investments and policy decisions to improve community health, provide the best care for patients and control infectious diseases such as HIV.

Dr. Aaron Carroll is director of mitigation testing for the Medical Response Team. He is also a Regenstrief Foundation Professor I, associate dean for research mentoring, a Bicentennial Professor and professor of pediatrics at the IU School of Medicine. Carroll is a health-related research writer for The New York Times and blogs on health research and policy at The Incidental Economist.

Carroll completed medical school at the University of Pennsylvania, a residency at the University of Washington and a fellowship through the Robert Wood Johnson Foundation Clinical Scholars Program.

These physicians, along with those on their core teams and IU leaders, review data and the current status of symptomatic testing, contact tracing and mitigation testing multiple times a week to ensure the university is operating in a way that keeps its students, faculty and staff as safe as possible.

"There's never one thing we're focused on; it's always a number of metrics and data sets," Beeler said. "With a pandemic and a complex population like IU, one number or metric could never tell us the whole story. It's reviewing all the pieces we've put in place to manage the pandemic and seeing how each is performing individually but also how they're working together. It's this full picture with all of these moving parts that we use to determine if a change would need to be made for the health and safety of the university community."

IU maintains a COVID-19 dashboard that includes data, reviewed by the Medical Response Team, on mitigation testing and symptomatic testing. It's this data, along with the Medical Response Team's analysis, that allows IU to evaluate health and safety and adjust the university's strategy in order to minimize the spread of COVID-19.

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Meet the top doctors leading IU's COVID-19 health, safety efforts - IU Newsroom

What to Know: Jobs coming to town and Preserve the Fort, Part deux – fortworthbusiness.com

500 jobs? Filling a nearly empty building? Jobs that pay an average of $75,000? A new journalism venture coming to town?

Ha! Got you.

Nope, Fort Worth and Texas officials are more than a little gleeful as they seem on the verge of filling the former FAA headquarters with another aviation-related company with the hope of bringing more than 500 corporate jobs. The city seemed at least to have the pretense of going through the motions of setting things up for the company to make the move. The news release from Gov. Greg Abbotts office made it sound like all 500 employees were already here and ordering another round of margaritas at Joe Ts.

Not quite yet, but still, its good news for a year where the business world is all about survival, not expansion and growth. This is a good sign.

Aviation-related company eyes Fort Worth for key expansion

Speaking of survival, the very popular Preserve the Fort grant campaign is up and running again.

Almost $9 million is available to businesses through these grants, which are funded by part of the City of Fort Worths CARES Act allocation, the city said in a news release.

Thanks to the success of the first round of Preserve the Fort grants earlier this summer, the citys Economic Development Department and United Way of Tarrant County have expanded the grant criteria to include slightly larger businesses with up to 500 employees, in addition to smaller for-profit businesses and self-employed individuals/independent contractors. It could be a life saver.

Fort Worth launches 2nd round of Preserve the Fort small business grant program

It was also a good day for the TCU and UNTHSC School of Medicine.

The late Anne Marion and the Burnett Foundation have made a $25 million gift to establish The Anne W. Marion Endowment in support of the operations of the TCU and UNTHSC School of Medicine in perpetuity.

This transformational gift will provide funds to support students, faculty and programming for the medical school, the school said in a news release.

$25 million gift for TCU and UNTHSC School of Medicine

Wednesday is National Guacamole Day and the Dallas Cowboys are actually playing football, which seemed so unlikely just a few months back. So what better time to celebrate both. Go for it on fourth down!

Yo Quiero! Brands, a North Texas-based company, earlier this summer announced a brand partnership with the Dallas Cowboys. So, no surprise there are some products with the Cowboy star that are ready to party with you.

Here are a couple of avocado jokes for the day:

A senior citizen comes to his weekly card game with a young guy wearing skinny jeans, wearing a beret and eating avocado toast.

His friends say:Who is this guy?

The senior citizen says: This is my hip replacement.

Whats an avocados favorite arcade game?

Guac-a-mole

Its National Guacamole Day! Heres one way to celebrate with Americas team

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What to Know: Jobs coming to town and Preserve the Fort, Part deux - fortworthbusiness.com

Osteopore to work with Singapore medical school on 3D printed jaws – Stockhead

Osteopore (ASX:OSX) has signed a research collaboration agreement with the National University of Singapore Yong Loo Lin School of Medicines Department of Surgery and the National University Hospital (NUH) to investigate the potential for using its 3D printed implants in reconstructing lower jawbones.

Patients may need mandibular reconstruction from bone loss due to trauma or disease, and while there are treatments available, including grafts, they can lead to post-surgical complications and donor site morbidities.

There are an estimated two or three mandibular reconstructions per week at NUH, Osteopore says.

Osteopore, the Department of Surgery at NUS Yong Loon Lin School of Medicine and NUH Department of Surgery will work together on a preliminary study to see if Osteopores 3D printed products could be combined with bone marrow aspirates to regrow bone.

Osteopore says its implants have a unique advantage in that they are bioresorbable and can be custom manufactured to fit each patient.

The main objective of the collaboration is to gain pre-clinical data for the evaluation of future studies.

The project has a long development pathway and theres no guarantee the company will be able to successfully commercialise the mandible products, Osteopore warned.

As previously reported, Osteopore has added the Australian Therapeutics Goods Administration (TGA) to its pool room shelf of regulators who think its bone healing products, in this case for the skull and face, are worthy of joining the Australian market.

The Singapore-based medical device company is commercialising a range of 3D printed bioresorbable scaffolds for regenerative bone healing, and in this case for use as bone void fillers.

The TGA has approved for use in Australia the Osteomesh, Osteoplug, and Osteoplug-C products, which European and US regulators have already done, together with Singapore and other East Asian regulatory clearances.

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What my parents did right to help me get into med school – Business Insider – Business Insider

It takes a special kind of person to want to go into medicine. The path is really hard, expensive, and incredibly self-doubting. One mitigating factor in all of that is having the right support system. Not only can a good support system really help with getting through medical school, but also the process of getting in.

Preparation, planning, and execution starts years before you ever start that first application. When you're still a child or young adult with all of these challenging, long-term goals, it's easy to be nearsighted and just live in the moment.

You know that eventually you want to become a doctor, lawyer, nurse, professional athlete, etc. At the same time, you don't want to be studying, training, or going to professional development camps all the time. You want to hang with friends, go out, and have fun. This was definitely how I was in high school, and well into college.

In high school I had good grades, strong extracurriculars, and the drive to do well. I have always been a competitive and determined person, but I also always had my parents there to push me just a little harder. As self-motivated as I was, there were several times where I got complacent, or just didn't really understand the work it would take to get where I wanted to go.

Read more: 'Microschool' entrepreneurs: 3 founders offering parents a safer, more personalized option for their kids and providing teachers a more lucrative career path

As simple as this message is, there are a lot of kids who don't get that push to just give their best effort no matter what. My parents and I had this conversation several times in regards to sports, academics, and any other aspects of my life. Without this encouragement and direction, I'm not sure I ever would have had the work ethic that it takes to pursue something as challenging and selective as medical school.

My parents also put a lot of value on education, which was also really important. I've worked with and studied with many kids who didn't care about school. It was merely a formality, or a legal obligation. When I spoke with many of them, they said their parents didn't put a lot of emphasis on attending school, and they just wanted to work, make money, and support their families.

This is a common value, and a very understandable one considering the socioeconomic background that my patients or friends came from. However, in the world we are in now, higher education can be the bridge to better health, social, and economical life. Almost any form of higher education is positively correlated with a better predicted life outcome. This is something my parents understood and instilled into me and my brothers.

This sounds extreme (it's the weekend, who cares when it gets done) and at the time I felt it was. But I realized later that my parents were trying to teach me the value of not procrastinating, and waiting until the last minute. There's a breath of fresh air you can breathe on Sunday night knowing that all of your assignments are done and you're not cramming and turning in subpar work. These are skills that they wanted me to carry through college, and eventually, medical school.

Dozier and her mom on family vacation in Las Vegas in September 2019. Darian Dozier

My mom went on to get her PhD while working a full-time job and taking care of my family. It was inspiring to watch her balance everything and still excel in a very challenging doctorate program. Was everything perfect all the time? No. But she tried her best in every aspect of her life, and that's the important value she wanted me to understand. You don't have to be perfect, you just have to try your best, and eventually, that will translate into being one of the best.

Read more: 6 bootcamps that cost little to nothing upfront, teach students crucial tech skills, and help them land roles at Google and Spotify

It's stressful, and questionable if that's the best approach, but when someone like a doctor has your life in their hands, you would hope that they have the mindset of trying to be their very best every day. You would hope that in the light of adversity, they would have the grit and resilience to problem-solve, and do everything they can to keep you alive and well.

These are just a few of the skills and lessons my parents wanted me to learn, and I really didn't understand it as a child. I thought they were being unnecessarily hard and putting a lot of pressure on me. Sometimes, I still feel that way. But I know, at the end of the day, it's so I can go out into a world that cares nothing about my feelings and excel no matter what.

It's these attributes that will help children become extraordinary and pursue the seemingly impossible. You don't have to have a PhD or even a Bachelor's or high school diploma to show your kids what's important. Just instill in them good values, a solid work ethic, and let them know the world is theirs for the taking, and they will excel in anything they put their minds to.

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Scailyte Announces Michael Brenner, of Harvard Medical School, as an Advisor to Its Board of Directo – PharmiWeb.com

BASEL, Switzerland-June 22, 2021- (Newswire.com)

Artificial Intelligence (AI)-driven biomarker discovery innovator Scailyte announced today that Michael Brenner MD, Elizabeth Fay Brigham Professor of Medicine at Harvard Medical School, has joined Scailyte as an advisor to the Board of Directors.

Prof. Brenner is the director of Brigham and Women's Hospital's Human Immunology Center, which creates and performs single-cell transcriptional analysis and functional investigations in order to decipher human autoimmune illnesses, stratify patient groups, and find prospective therapeutic target cells and pathways. He is a member of the National Academy of Sciences in the United States and has received numerous awards.

Prof Brenner's research focuses on T cell biology, antigen presentation, microbial pathogenesis, and autoimmunity. His research discovered the integrin molecule aEb7 (CD103) and its role in leukocyte homing, as well as a role for the CD1 antigen presentation system in the activation of T cells and NKT cells. His team has recently identified distinct fibroblast subpopulations that are pathologically expanded in disease, as well as a new T helper cell population, T peripheral helper (Tph) cells, that are implicated in antibody production in autoantibody-mediated disorders.

Michael Brenner, MD comments: "I am thrilled to support Scailyte in their pioneering efforts combining single-cell technologies and artificial intelligence for biomarker discovery. Single-cell technology is moving into the clinical space, and Scailyte is there at the right moment to capture the potential and create a new generation of clinical applications that will make a difference for patients."

About Scailyte

Scailyte AG is a spin-off of ETH Zurich and combines single-cell technologies, high-quality datasets and machine learning methods to identify disease-specific biomarkers, with a focus on oncology and immunology. Scailyte's proprietary best-in-class data analysis platform ScaiVision associates multimodal single-cell datasets (RNA-/TCR-/BCR-seq, proteomics, etc) with clinical endpoints, such as disease diagnosis, progression, severity, treatment response, in order to identify ultra-sensitive biomarker signatures. Thanks to the single-cell resolution and AI-driven approach, ScaiVision is the most powerful and cutting-edge approach to develop methods for precise diagnosis and prediction of therapy response. Scailyte leverages a global network of clinicians to identify disease indications with high unmet needs and collaborates with global pharmaceutical and biotech companies to translate the novel biomarkers into ultra-sensitive companion diagnostics (CDx) and IVD assays.

For more information, visit http://www.scailyte.com and connect on social media @LinkedIn and @Twitter.

Press Release ServicebyNewswire.com

Original Source:Scailyte Announces Michael Brenner, of Harvard Medical School, as an Advisor to Its Board of Directors

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Scailyte Announces Michael Brenner, of Harvard Medical School, as an Advisor to Its Board of Directo - PharmiWeb.com

Bloomberg to Give $100 Million to Black Medical Schools – The New York Times

In the midst of the pandemic, Michael R. Bloomberg is focusing on a unique way to improve the health of Black communities: by giving money to Black students studying to become doctors.

Mr. Bloomberg, the billionaire and former mayor of New York, announced on Thursday that his philanthropic organization would give $100 million to four historically Black medical schools.

The immediate goal is to reduce medical students financial burdens by giving about 800 of them up to $100,000 in grants. The bigger goal, architects of the gift say, is to improve the health and wealth of Black Americans.

If the goal of the portfolio is to create intergenerational wealth, we have to think about the mortality and the life span of the Black community, said Garnesha Ezediaro, program lead for the Greenwood Initiative, Mr. Bloombergs philanthropic effort meant to address the systemic economic inequity faced by Black Americans.

The gift is the first major donation by the Greenwood Initiative, which is named after the Tulsa district where hundreds of Black Oklahomans were massacred in 1921. Mr. Bloomberg introduced the initiative as part of his presidential campaign, during which he was forced to apologize for policies he instituted as mayor, most notably the aggressive stop-and-frisk policing strategy that disproportionately disadvantaged Black and Hispanic New Yorkers.

Leaders of the four institutions Charles R. Drew University of Science and Medicine, in Los Angeles; Howard University College of Medicine, in Washington; Meharry Medical College, in Nashville; and Morehouse School of Medicine, in Atlanta say the donation is one of the biggest by a single donor to historically Black schools. They hope that it highlights the importance of their institutions to the well-being of Black communities.

Mr. Bloombergs donation follows others to historically Black colleges, like the $120 million pledge by the Netflix chief executive Reed Hastings and his wife, Patty Quillin, and a series of multimillion-dollar gifts from MacKenzie Scott, the author and philanthropist who was once married to the Amazon founder Jeff Bezos. In 2013, Mr. Bloomberg gave $1.1 billion to his alma mater, Johns Hopkins University, with a key focus on its public health school.

After Mr. Bloomberg abandoned his electoral ambitions, he began canvassing for ways to lift up Black communities. One concern that emerged as the coronavirus spread was the disproportionate devastation in Black communities.

The data is clear: Black patients over all have better outcomes when they get treatment from Black doctors, the famously data-driven Mr. Bloomberg wrote in an email. By increasing the number of Black doctors, we hope the gift will help to save more Black lives and reduce the health problems that limit economic opportunity in Black communities.

Mr. Bloombergs representatives began reaching out to the schools officials around four weeks ago, asking how to best improve Black communities wealth, said Dr. Wayne Frederick, the president of Howard University. The answer: Increase the number of Black doctors.

And free from a pressing need to repay student debt the average burden on graduating students from these institutions is about $285,000 more of the doctors may choose to become primary care physicians in needy communities, said Dr. Valerie Montgomery Rice, the president and dean of Morehouse School of Medicine.

What we will have the opportunity to do with this reward is relieve the stress of those students, she said.

Under the terms of the gift, students graduating between 2021 and 2024 are eligible for the grants. The donation does not require students to choose a particular specialty.

In the longer term, school officials hope Mr. Bloombergs donation helps raise awareness, particularly for other potential donors, of the institutions and the role they play. Dr. James E.K. Hildreth, the president of Meharry, noted that the schools alumni often lacked the opportunity to earn as much as their white counterparts, limiting how much they could donate to their alma maters.

One ambition is to make education at these institutions free, as New York Universitys School of Medicine announced it would do in 2018 after raising $450 million from benefactors.

Dr. David M. Carlisle, the president and chief executive of Charles R. Drew, said that these funds are really going to shout to the world that historically Black medical schools are not just there, but that theyre there in a big, meaningful way.

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Trump doctor Conley degree from Philadelphia College of Osteopathic Medicine: What it means – On top of Philly news – Billy Penn

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The doctor whos been treating President Donald Trump for the coronavirus has roots in Philadelphia. Its where he trained in medicine

Dr. Sean Conley, the 40-year-old whos been at the forefront of national health updates lately, has been the presidents physician for two years. He grew up in Doylestown, and graduated from Central Bucks High School East in 1998. His medical degree comes from the Philadelphia College of Osteopathic Medicine.

The Philly higher ed institution is not your average medical school. Turns out Conley doesnt actually have an MD degree.

Instead, hes a DO a doctor of osteopathic medicine. With that certification, Conley can do everything a regular doctor can do, like prescribe medicine and perform surgery in all 50 states.

The training is different in that it takes a more holistic look at the body than traditional medicine. It emphasizes primary care, and practices that encourage the body to heal itself rather than the immediate prescription of medicine or use of surgery to correct problems.

At first, the practice was highly controversial. During the first decade of PCOMs existence, it wasnt even legal in Pennsylvania. Over the next two centuries, debates over osteopathy continued, with traditional physicians critiquing its more controversial practices like the in the late 1800s idea to shake a child to cure scarlet fever.

In recent years, the stigma has mostly dissolved as the training and practice have themselves become more legit. Now, earning a DO degree requires the same training as an MD, plus extra coursework.

Conleys Philly alma mater is considered a pioneer in the field, and helped see it through to the modern day.

The first person to bring osteopathic medicine to Philadelphia was a woman named Clara Martin. In 1899, the city directory listed her as an osteopath, working from an office on 67th Street near the Cobbs Creek Parkway, just south of Mount Moriah Cemetery.

That same year, two physicians named Snyder and Pressly founded what would become PCOM, then called the Philadelphia College and Infirmary of Osteopathy.

Philly was experiencing a general boom in medical institutions right then, notes a published history of the school called To Secure Merit, by Carol Benenson Perloff. Episcopal Hospital, German Hospital (now Lankenau), Jewish Hospital (now Einstein Medical Center) and Presbyterian Hospital were all founded between 1849 and 1882.

PCOM first opened at 12th and Market, filling two rooms inside a 13-story office tower. Within a year, it outgrew that space and relocated to the Witherspoon building at Juniper and Walnut.

Enrollment kept growing. Many students were people inspired by seeing osteopathic doctors step in after traditional medicine had failed.

Alum Arthur Flack, who graduated in 1906, said he got interested when he saw osteopathic medicine helped cure cases of typhoid fever amid an epidemic in his hometown of Butler, Pa.

When I first became a studentmy marvel was as to the intense devotion manifested by the small group of physicians headed by you, Flack said in 1925, according to Perloffs book. Without such sincere devotion, Osteopathy today would be only a memory in Pennsylvania.

Thing is, osteopathy wasnt even legally recognized when PCOM first opened its doors.

The first attempt to legalize it in Pennsylvania passed through the state legislature in 1905, but was vetoed by then-Governor Pennypacker. It wasnt until 1909 that a Governor Stuart signed the bill to allow osteopathic doctors to apply for state licensure, 10 years after the Philadelphia college was first founded.

Licensing made the practice more popular, and PCOM continued to outgrow its facilities. The school moved to Spring Garden Street, then to 33rd and Arch, and eventually to North Broad Street.

Some drama: Before the legalization of osteopathy, the college had raised about $3,000. But the founders continued not to pay faculty with actual money for their teaching they compensated them only with stock in the school.

In 1904, faculty started demanding payment. The founders refused, and there was a theatrical back-and-forth in which the schools deans threatened to resign unless the two founders resigned. Shockingly, both founders did resign, and a board of trustees was established that still exists today.

By 1910, PCOM was considered a pioneer when it became one of the first to adapt to new statewide legalization requirements, and create a four-year program, which it maintains to this day.

After those gazillion relocations and expansions, PCOM landed at its current campus on City Avenue at the Bala Cynwyd border.

The school currently has almost 2,000 students, across areas of study like clinical psychology, biomedical sciences and forensic medicine. Like osteopathic medicine schools nationwide, its really tough to get in. In 2019, nearly 7k students applied for just 441 spots in the program.

Dr. Conley, Trumps doctor, has a degree that takes four years to complete. The first two are spent learning basic and clinical sciences, and the second two doing hands-on work in teaching hospitals.

While enrolled, the Bucks County native likely got plenty of Philly experience, since students spend four months working in city neighborhoods at PCOMs Community Healthcare Centers.

After their four years, some students declare a specialty and spend more time in school. PCOM reports that a majority of its grads end up in family medicine, general internal medicine, OB/GYN or pediatrics.

In general, osteopathic medicine has grown in popularity in recent years seen as a more hands-on version of health care. DOs work to understand how all parts of the body are connected, and take a major focus on preventative and primary care.

An osteopathic medicine student in New York told the New York Times in 2014 she became interested in the practice after a standard MD said shed need surgery to correct her chronic ear infections but then she went to a DO, who corrected the problem by stretching her neck, she said.

The infection happened because of fluid in the ear, said the student, Gabrielle Rozenberg, and the manipulations opened up the ear canal.

The practice has become widespread enough that PCOM has opened two more campuses, both in Georgia. According to the American Association of Colleges of Osteopathic Medicine, about 25% of all medical students today are training at an osteopathic school.

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Trump doctor Conley degree from Philadelphia College of Osteopathic Medicine: What it means - On top of Philly news - Billy Penn

Revising the history and physical for new era in medicine – American Medical Association

Even setting aside the once-in-a-lifetime impact of the pandemic, the physicians role in 2020 is substantially different than it was a decade ago. Todays patients are often sicker, and illness is compounded by numerous nonbiomedical factors, such as inadequate social support to comply with treatment plans and avoid unnecessary hospitalizations.

The COVID-19 pandemic is complicating things further by stalling many clinical research and quality improvement efforts. But a project funded by a grant from the AMA Accelerating Change in Medical Education initiative continues training students at four U.S. medical schools to incorporate a new history and physical (H&P) modelthe H&P 360to collect biopsychosocial data, better manage chronic disease and address social determinants of health.

The four medical schools receiving the H&P 360 implementation grants are the University of Michigan, Eastern Virginia Medical School, Florida International University and University of Chicago.

While the H&P is the primary process through which a physician obtains key subjective and objective patient information, the traditional H&P was developed decades ago when the physicians role was more limited.

Medical practice is necessarily undergoing a paradigm shift, and the new paradigm has to do with accounting for social determinants and behavioral health, said Brent Williams, MD, MPH, director of the Global Health and Disparities Path of Excellence at University of Michigan Medical School.

The H&P 360 is meant to help physicians stop making the mistakes that are in built into the old medical paradigm, which is based exclusively on biomedical disease diagnosis and treatment, Dr. Williams added. It pushes them to take a realistic view of why so many patients bounce back into the hospitalfor example, because they didn't have access to their medications or they didn't take them appropriately.

Based on a format developed at University of Michigan Medical School, the H&P 360 was expanded and refined by the AMAs Chronic Disease Prevention and Management interest group in 2017 and piloted at four medical schools in 2018.

The idea behind the H&P 360 is that by including at least a few questions in each of six domains besides the traditional biomedical information in the routine history, physicians care of patients will improve.

Those additional domains are:

For example, in the relationships domain, students are being trained to assess the level of support available to their patients. They might ask questions such as:

The effectiveness of the H&P 360 is supported by a 2019 randomized-controlled trial with standardized patients. Nearly 160 third- and fourth-year medical students at four medical schoolsUniversity of Michigan, University of North Dakota, University of Connecticut and University of California, Daviswere randomly assigned to either the traditional H&P or the H&P 360 and further randomized to either see a patient with hypertension or a patient with type 2 diabetes.

For each encounter, a standardized patient doubled as a trained observer and completed a grading rubric that measured:

Analysis of the data demonstrated average total scores on the performance rubric were substantially higher among the intervention group in both cases, at all four schools and across all four standardized patients.

Dr. Williams noted that the grant groups students have returned to clinical settings and are now implementing H&P 360 during both in-person and virtual visits.

While the pandemic has disrupted or delayed some of the work, it has also made it easier to apply the H&P 360, he said. With video visits, medical students are drawn more directly into patients living environments and social support systems.

No matter the type of visit, however, what makes the H&P 360 such a practical tool is that its not a checklist that has to be included in every visit, Dr. Williams added. By gathering just two or three pieces of information each time, the physician will gradually get a more complete picture of a patients health and the paths to improvement.

The long-term goal for H&P 360 is to make it the standard tool in medical practice for improvement of all aspects of chronic disease prevention, diagnosis, treatment and management. The H&P 360 template and supporting materials are available for use at all medical schools.

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Revising the history and physical for new era in medicine - American Medical Association

What is medical education research? – Baylor College of Medicine News

In order for us to train medical students to be the best physicians they can be, we have to be the best medical educators that we can be. That includes keeping up with our colleagues around the country on best practices and sharing our own experiences. This is why medical education research is so important.

When I say that I do medical education research, I get a lot of funny looks. Many people dont understand what it is or what it looks like, and they dont understand that its important research, just like basic science or clinical research.

There is a science to the neurobiology of how we actually learn, and learning takes place in many environments, including the classroom and the clinic. We publish guidelines and protocols for best practices in medical education, just as clinicians publish the newest diagnosis and treatment protocols.

We also perform trials comparing one method of teaching to another, and study how our education interventions effect outcomes.

The very first goal in our Baylor College of Medicine School of Medicine strategic plan is to establish Baylor College of Medicine School of Medicine as an international leader in medical education innovation and pedagogy and our medical education scholarship is one of the ways that we will get there.

Its important to us that our learners are exposed to the latest technologies, learning tools, and pedagogy because that training will ultimately help them provide the best care to patients. Its impossible to teach students everything there is to know about medicine. I believe it should not be our aim to even try.

I believe that we should focus much more attention on teaching students how to critically appraise, apply knowledge and become consciously competent master adaptive learners.

For example, one recent finding about medical education showed us that learners do better when they are active participants in the learning process. There is now far too much evidence that shows lecture-based learning is not effective.

As a result, we have been transforming the first 18 months of our curriculum. We have increased the amount of active learning in every class, utilizing techniques such as flipped classrooms and team-based learning. New courses have been introduced that are 100% active learning.

I have to admit that one of my favorite things about my job is indeed the research aspect of what I do implementing the latest science in teaching and learning and studying its effects. I love curling up with my academic journals and reading them cover to cover, and I actually love writing papers.

I have collaborated on numerous studies with colleagues from around the country. I find that working with other institutions validates the problems that we all face in medical education. They are not unique and its great to problem solve together.

One recent challenge that we faced during the COVID pandemic was how we could continue to effectively teach our students who were pulled from the clinical learning environment. After consulting with counterparts across the country, we found that we needed to increase our usage of high quality, interactive, online patient cases.

Utilizing these cases that provide the opportunity for critical thinking should not be limited to our clinical students they should be the foundation of how we teach students from the first day of medical school. Adult learning theory supports that even students with no medical training can work through clinical cases albeit at a different level than senior students.

Doing medical education research is part of how educators get promoted up the ranks just like in basic science/clinical science, and we disseminate our findings in scholarly fashions the same way through posters and abstracts at national conferences, as well as in publications.

One difference is while there are opportunities for grants, there are not quite as many available for pure medical education research. Most are in much smaller amounts. However, much medical education research could be incorporated into the basic science and clinical research grants that are submitted at health sciences universities.

I try to mentor all junior faculty educators to study what they do. Make sure to turn that abstract into a paper and be persistent when submitting work for publication. It may not get accepted the first time around, but persistence really does win out.

We need to be more cognizant about publishing what we do so that others can learn from it. There is no point in every institution recreating the wheel and my goal is that Baylor will be creating those wheels and looked at as the leader in medical education.

-By Dr. Jennifer Christner, dean of the School of Medicine at Baylor College of Medicine

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What is medical education research? - Baylor College of Medicine News