[No Man’s Sky info] AI, Naming, Chemistry etc Compact interview compilation 5 – Video

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[No Man #39;s Sky info] AI, Naming, Chemistry etc Compact interview compilation 5
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[No Man's Sky info] AI, Naming, Chemistry etc Compact interview compilation 5 - Video

Mayor of Texas chemical blast town on latest EPA deregulation: They have a short memory – Electrek

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The Environmental Protection Agency (EPA) announced yesterday that they were ending regulations that require chemical plants to provide the public with information about potential risks.

EPA administrator Andrew Wheeler says the regulations were unnecessary administrative burdens. Chemical manufacturers lobbied (clearly successfully) for this change.

In 2013, there was a fire at the West Fertilizer Co. plant in West, Texas. It caused ammonium nitrate to ignite, and it triggered a huge explosion that destroyed the plant, as well as a nearby nursing home and apartment complex.

The explosion killed 15 people, 10 of whom were firefighters.

The EPA then put regulations in place under the Obama administration that required chemical plants to provide information upon request to members of the public about risks.

The Dallas Morning News reports:

When new regulations were enacted after a deadly fertilizer plant explosion killed 15 people in a Texas town south of Dallas, West Mayor Tommy Muska hadnt even had the chance to read the rules before they were obsolete.

A week after the Obama-era rules regulating how companies store dangerous chemicals were put in place, the administration of newly inaugurated President Donald Trump put them on hold in January 2017.

Muska was in his first term as mayor when the explosion rocked West on April 17, 2013.

By the time I got [the Obama rules] in my hands, it was already part of the Trump administration, and they shelved it, Muska said Thursday. I was somewhat disappointed. I would love for them to revisit some of those processes that go into chemical storage. Theres a happy medium between economic concerns brought on by regulation and protecting the public.

The American people and American politicians, they have a short memory, Muska said. Theyre going to say everything is fine, and every few years something like this is going to happen again, and Oh, yeah, we need to look at this again.

Were yesterdays news. Its not on anybodys minds as it was in 13 and 14.

If you lived next to a chemical plant, would you want to know what was being manufactured there, and what the risk was to the environment, your home, your family, your health, and your own life? Yeah, we thought so. Imagine what a blow this rollback announcement was to the people who lived in the nursing home and the apartment complex and to the families of those who lost their lives. And clearly, its a blow to the mayor of West, who had to lead during an awful tragedy.

Way to put profit before people, EPA. The focus of your press release is about how much money youre going to save but it doesnt quantify that or provide evidence. It might be time to change your name to something else.

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Mayor of Texas chemical blast town on latest EPA deregulation: They have a short memory - Electrek

Electron Transport Chemistry Is Involved In DNA Replication – ReliaWire

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The electrical wire-like behavior of DNA is involved in the molecules replication, new research from California Institute of Technology has shown.

In the early 1990s, Jacqueline Barton, the John G. Kirkwood and Arthur A. Noyes Professor of Chemistry at Caltech, discovered an unexpected property of DNA. It can act like an electrical wire to transfer electrons quickly across long distances.

Later, she and her colleagues showed that cells take advantage of this trait to help locate and repair potentially harmful mutations to DNA.

Now, Bartons lab has shown that this wire-like property of DNA is also involved in a different critical cellular function: replicating DNA.

When cells divide and replicate themselves in our bodies, for example in the brain, heart, bone marrow, and fingernails, the double-stranded helix of DNA is copied. DNA also copies itself in reproductive cells that are passed on to progeny.

Barton, lead author of the study, says:

Nature is the best chemist and knows exactly how to take advantage of DNA electron-transport chemistry. The electron transfer process in DNA occurs very quickly. It makes sense that the cell would utilize this quick-acting pathway to regulate DNA replication, which necessarily is a very rapid process.

The researchers found their first clue that DNA replication might involve the transport of electrons through the double helix by taking a closer look at the proteins involved. Two of the main players in DNA replication, critical at the start of the process, are the proteins DNA primase and DNA polymerase alpha.

DNA primase typically binds to single-stranded, uncoiled DNA to begin the replication process. It creates a primer made of RNA to help DNA polymerase alpha start its job of copying the single strand of DNA to create a new segment of double-helical DNA.

DNA primase and DNA polymerase alpha molecules both contain iron-sulfur clusters.

Barton and her colleagues previously discovered that these metal clusters are crucial for DNA electron transport in DNA repair. These DNA repair proteins send electrons down the double helix to other DNA-bound repair proteins as a way to test the line, so to speak, and make sure there are no mutations in the DNA.

If there are mutations, the line is essentially broken, alerting the cell that mutations are in need of repair. The iron-sulfur clusters in these DNA repair proteins are responsible for donating and accepting traveling electrons.

Barton and her group wanted to know if the iron-sulfur clusters were doing something similar in the DNA-replication proteins.

We knew the iron-sulfur clusters must be doing something in the DNA-replication proteins, otherwise why would they be there? Iron can damage the DNA, so nature would not have wanted the iron there were it not for a good reason, says Barton.

Through a series of tests in which mutations were introduced into the DNA primase protein, the researchers showed that this protein needs to be in an oxidized state which means it has lost electrons to bind tightly to DNA and participate in DNA electron transport. When the protein is reduced meaning it has gained electrons it does not bind tightly to DNA.

The electronic state of the iron-sulfur cluster in DNA primase acts like an on/off switch to initiate DNA replication, says OBrien.

Whats more, the researchers demonstrated that electron transport through DNA plays a role in signaling DNA primase to leave the DNA strand. Although DNA primase must bind to single-stranded DNA to kick off replication, the process cannot begin in earnest until the protein pops back off the strand.

The scientists propose that the DNA polymerase alpha protein, which sits on the double helix strand, sends electrons down the strand to DNA primase.

DNA primase accepts the electrons, becomes reduced, and lets go of the DNA. This donation and acceptance of electrons is done with the help of the iron-sulfur clusters.

You have to get the DNA primase off the DNA quickly; that really starts the whole replication process, says Barton. Its a hand off of electrons from one cluster to the other through the DNA double helix.

Many proteins involved in DNA reactions also contain iron-sulfur clusters and may also play roles in DNA electron transport chemistry, Barton says. What began as a fundamental question 25 years ago about whether DNA could support migration of electrons continues to lead to new questions about the chemical workings of cells.

Image: A protein called DNA primase (tan) begins to replicate DNA when an iron-sulfur cluster within it is oxidized, or loses an electron (blue and purple). Once this primase has made an RNA primer, a protein signaling partner, presumably DNA polymerase alpha (blue), sends an electron from its reduced cluster, which has an extra electron (yellow and red). The electron travels through the DNA/RNA helix to primase, which comes off the DNA. This electron transfer signals the next steps in replication. Credit: Caltech

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Electron Transport Chemistry Is Involved In DNA Replication - ReliaWire