Put priority in its place | Opinion – Chemistry World

We have a thirst for firsts. The first person to achieve something gets their place in history, and competing to be first is a powerful motivator even when the goal is effectively arbitrary. In October, Eliud Kipchoge (unofficially) became the first person to run a marathon in under two hours. It was an incredible feat of endurance, but Kipchoges official record set in 2018 is 2:01:39, and from where I sit, 7299 seconds is no less impressive than 7200 seconds. Still, such symbolic firsts inspire intense competition and they are just as seductive to scientists as they are to sportspeople.

As we reported recently, scientists are now very near to making the first room temperature superconductor, with a lanthanum hydrides 13C transition temperature coming tantalisingly close. In this particular room, the thermostat sits just north of 0C, which is a little wintry for most but its a good deal warmer than the liquid nitrogen temperatures needed by cuprate ceramics that were the previous best in class.

Yet hitting room temperature wont herald the dawn of widespread superconducting technology. Yes, the temperature is more readily achievable, but practicality is still a long way off when the materials also have to be crushed under a million atmospheres of pressure. So this will be a far more symbolic than scientific effort. As Mikhail Eremets one of the researchers hoping to break the barrier told Nature, the target has no real physical meaning. However, it is enormously important psychologically.

The race to make the first room temperature superconductor shows how human behaviour influences scientific progress. Getting a superconductor over this psychological threshold may be pretty incremental; its well within reach and we know how well make up the difference. But it represents decades of work the lifetime of an entire field and will make headlines around the world. There may even be a Nobel in it for the discoverers. All of which is spurring on the few groups working in the field to claim the prize any of them could be the first to get there and only one of them will. In the science economy, that priority carries a significant premium.

Yet while competition for first place is the lifeblood of athletics and sports, in science it can come with damaging consequences. In an editorial for Infection and Immunity in 2015, Ferric Fang and Arturo Casadevall argued that this competitive drive for priority does science far more harm than good it leads to wasted effort, it stifles creativity, breeds secrecy and creates a hostile environment for young scientists, especially young women. Just look at our history.

As the International Year of the Periodic Table draws to a close, and we reflect on a year of celebration, we should also note what the table teaches us about our culture. Scratch the tables surface just about anywhere and youll find an argument about who deserves the credit lurking underneath; the table is littered with priority disputes and our obsession with the idea of individual genius. Today, a handful of teams around the world compete to be the first to synthesise the next element, and for the right to name it, which will very likely honour an individual person or nation. The table is sciences culture in microcosm; every inch of it is covered in our motivations, like smudgy fingerprints.

So how do we address this fixation with firsts, when it is so embedded in our culture? It seems fanciful to think we can just forget about them pushing back the frontiers means someone has to be at the front. Perhaps we can instead broaden the scope of that culture to include other motivations altruism, charity and curiosity, for example so that these are more apparent in the way we carry out and celebrate science. The problem with focusing only on firsts is that it pushes everyone else into last.

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Put priority in its place | Opinion - Chemistry World

Minuscule chemical tweak is advancing an organic solar technology that was once thought unviable – pvbuzz media

A solar energy material that is remarkably durable and affordable is regrettably also unusable if it barely generates electricity, thus many researchers had abandoned emerging organic solar technologies. But lately, a shift in the underlying chemistry has boosted power output, and a new study has revealed counterintuitive tweaks making the new chemistry successful.

The shift is from fullerene to non-fullerene acceptors (NFAs), terms detailed below, and in photovoltaic electricity generation, the acceptor is a molecule with the potential to be to electrons what a catcher is to a baseball. Corresponding donor molecules pitch electrons to acceptor catchers to create electric current. Highly cited chemist Jean-Luc Brdas at the Georgia Institute of Technology has furthered the technology and also led the new study.

NFAs are complex beasts and do things that current silicon solar technology does not. You can shape them, make them semi-transparent or colored. But their big potential is in the possibility of fine-tuning how they free up and move electrons to generate electricity, said Brdas, a Regents Professor in Georgia Techs School of Chemistry and Biochemistry.

Gaining on silicon

In just the last four years, tuning NFA chemistry has boosted organic photovoltaic technology from initially converting only 1% of sunlight into electricity to 18% conversion in recent experiments. By comparison, high-quality silicon solar modules already on the market convert about 20%.

Theory says we should be able to reach over 25% conversion with organic NFA-based solar if we can control energy loss by way of the morphology, said Tonghui Wang, a postdoctoral researcher in Brdas lab and first author of the study.

Morphology, the shapes molecules take in a material, is key to NFA solar technologys heightened efficiency, but how that works on the molecular level has been a mystery. The new study carefully modeled tiny tweaks to molecular shapes and calculated corresponding energy conversion in a common NFA electron donor/acceptor pairing.

Improved performance came not from tweaks to the metaphorical hand of the catcher nor from the donors pitching hand but from something akin to positions of the catchers feet. Some positions better aligned the body of the acceptor with that of the electron donor.

The feet were a tiny component, a methoxy group, on the acceptor, and two positions out of four possible positions it took boosted the conversion of light into electricity from 6% to 12%. Brdas and Wang published their study, Organic Solar Cells Based on Non-Fullerene Small Molecule Acceptors: Impact of Substituent Position, on November 20, 2019, in the journal Matter. The research was funded by the Office of Naval Research.

(The donor/acceptor chemical pair was PBDB-T / IT-OM-1, -2, -3, or -4, with -2 and -3 showing superior electricity generation.)

Clunky silicon cells

Marketable NFA-based solar cells could have many advantages over silicon, which requires mining quartz gravel, smelting it like iron, purifying it like steel, then cutting and machining it. By contrast, organic solar cells start as inexpensive solvents that can be printed onto surfaces.

Silicon cells are usually stiff and heavy and weaken with heat and light stress, whereas NFA-based solar cells are light, flexible, and stress-resistant. They also have more complex photoelectric properties. In NFA-based photoactive layers, when photons excite electrons out of the outer orbits of donor molecules, the electrons dance around the electron holes they have created, setting them up for a customized handoff to acceptors.

Silicon pops an electron out of orbit when photons excite it past a threshold. Its on or off; you either get a conduction electron or no conduction electron, said Brdas, who is also Vasser Woolley Chair in Molecular Design at Georgia Tech. NFAs are subtler. An electron donor reaches out an electron, and the electron acceptor tugs it away. The ability to adjust morphology makes the electron handoff tunable.

Not a fullerene

Like the name says, non-fullerene acceptors are not fullerenes, which are pure carbon molecules with rather uniform and geometric structures of repeating pentagonal or hexagonal elements. Nanotubes, graphene, and soot are examples of fullerenes, which are named after architect Buckminster Fuller, who was famous for designing geodesic domes.

Fullerenes are more ridged in molecular structure and tunability than non-fullerenes, which are more freely designed to be floppy and bendable. NFA-based donors and acceptors can wrap around each other like precise swirls of chocolate and vanilla batter in a Bundt cake, giving them advantages beyond electron donating and accepting such as better molecular packing in a material.

Another point is how the acceptor molecules are connected to each other so that the accepted electron has a conductive path to an electrode, Brdas said. And it goes for the donors, too.

As in any solar cell, conduction electrons need a way out of the photovoltaic material into an electrode, and there has to be a return path to the opposite electrode for arriving electrons to fill holes that departing electrons left behind.

Highly impactful citations

Brdas accolades are numerous, but he has particularly gained attention for his Google Scholar h-index score, a calculation of the impact of a researchers publications. Bredas current score of 146 likely places him in the 700 most-impactful published researchers in modern global history.

He has been a particularly noted leader in photoelectric and semiconductor research based on affordable and practical organic chemistry.

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Chemistry (relationship) – Wikipedia

In the context of relationships, chemistry is a simple "emotion"[1] that two people get when they share a special connection. It is not necessarily sexual. It is the impulse making one think "I need to see this [other] person again" - that feeling of "we click".[2] It is very early in one's relationship that they can intuitively work out whether they have positive or negative chemistry.[3]

While the actual definition of chemistry, its components, and its manifestations are fairly vague, this is a well documented concept. Some people describe chemistry in metaphorical terms, such as "like cookie dough and vanilla ice cream", or "like a performance".[4] It can be described in the terms of mutual feelings - "a connection, a bond or common feeling between two people", or as a chemical process - "[it] stimulates love or sexual attraction...brain chemicals are definitely involved".[3] While chemistry has been described as "that romantic spark between [two people]", the term "spark" in the context of relationships is as vague as "chemistry", and therefore is not particularly useful in a definition.[1] It has also been described as "intangible, unspoken [and] energetic".[5] Chemistry is an unconscious decision, informed by a complex blend of criteria.[2]

Some of the core components of chemistry are: "non-judgment, similarity, mystery, attraction, mutual trust, and effortless communication"[3] Chemistry can be described as the combination of "love, lust, infatuation, and a desire to be involved intimately with someone".[2]

Research by Kelly Campbell, Ph.D., suggests that "not everyone experiences chemistry". She decided that "chemistry occurred most often between people who are down-to-earth and sincere". This is because "if a person is comfortable with themselves, they are better able to express their true self to the world, which makes it easier to get to know them...even if perspectives on important matters differed." Sharing similarities is also deemed essential to chemistry as "feeling understood is essential to forming relational bonds."[3]

In general terms, there are 3 main types of chemistry, which are defined in terms of the nature of the rapport between the respective people:[6]

The various manifestations of chemistry are: sexual chemistry, romantic chemistry, emotional chemistry, activity chemistry, team performance chemistry, creative chemistry, intellectual chemistry, and empowerment chemistry".[6]

There are various psychological, physical and emotional symptoms of having good chemistry with another person. It has been described as a "combination of basic psychological arousal combined with a feeling of pleasure". The nervous system gets aroused, causing one to get adrenaline in the form of "rapid heartbeat, shortness of breath, and sensations of excitement that are often similar to sensations associated with danger". Other physical symptoms include "blood pressure go[ing] up a little, the skin...flush[ing], the face and ears...turn[ing] red and...[a] feeling of weakness in the knees". One can feel a sense of obsession over the other person, longing for "the day [when they return] to that person". One can also uncontrollably smile whenever thinking about the other person.[3]

There is some debate over whether one can artificially create chemistry if they are "not initially feeling it". While some people hold that it is something that you "can't learn and can't teach...[and you] either have...or you don't", others hold that chemistry is a process rather than a moment, "build[ing] up and adds up and eventually you get this kind of chemical bonding". Some people, while believing it is possible to artificially create chemistry, think that it is better to let chemistry hit them spontaneously.[3]

In Western Society, chemistry is generally considered the "igniter [and] catalyst for the relationship", i.e., without this chemistry, there can be no relationship.[3] Having chemistry "can be the difference between a relationship being romantic or platonic". Chemistry "can cause people to act sexually impulsively or unwisely". It can also be the difference between someone remaining faithful in their relationship, and seeking one night stands and affairs.[1]

Romantic chemistry can be one of the most dangerous and self destructive emotions if left unchecked. Some people will enter relationships with incompatible mates blinded by chemistry. Chemistry often seems to have the power to blind us. Chemistry is the reason the saying, "Love is blind," exists. Chemistry can make otherwise rational people ignore serious problems and issues in an individual and relationship. Chemistry often blinds people to warning signs that a person or relationship is not healthy or the right one for them.

Dating coach Evan Marc Katz suggests that "chemistry is one of the most misleading indicators of a future relationship. Chemistry predicts nothing but chemistry." This is because chemistry can make people blind to actual incompatibilities or warning signs. Psychologist Laurie Betito notes that arranged marriages actually do quite well in terms of relationship satisfaction, and this is because "a spark can build based on what you have in common. You can grow into love, but you grow out of lust."[7]

Neil Clark Warren argues that physical chemistry is important because "couples who don't share strong chemistry may have additional problems during the ups and downs of a life together." Like Betito, he suggests not ruling someone out on the first date due to lack of chemistry. "But," he adds, "if by the second or third date you dont feel a strong inclination to kiss the other person, be near him, or hold his hand, youre probably never going to feel it."[8]April Masini likewise says that chemistry is a strong predictor of relationship success. She suggests that chemistry comes and goes, and it's important to actively cultivate it because it can help couples deal with future conflicts.[9]

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Chemistry (relationship) - Wikipedia

A Chemical Missionary – Adventist Review

August 11, 2017

By: Marcos Paseggi, Adventist Review

How can I be a chemical missionary? What can the chemicals that make up this world and universe tell us about the Creator?

These are some of the questions Andrews University (AU) Chemistry Professor Ryan Hayes asks himself time and again when reflecting on the intersections of his beliefs and the field of science he loves.

Hayes, an AU alumnus who returned to his alma mater to teach after a decade of further studies and work in the chemical industry, offered a hands-on one-size-fits-all seminar, during the 2017 Adventist Laymens Services and Industries (ASi) Convention in Houston, Texas, United States, on August 4. In it, he explored some of the unanswered questions for naturalists and shared a work-in-process initiative that he hopes will provide novel resources for integrating faith into Chemistry learning.

A Missing Link

Hayes notes that most scholarly discussions about origins have traditionally focused on either Physicsthe depth of time, and Biologythe complexity of life, but not on Chemistry, which he called the missing link. But how is this world put together? he asks. How did God make this world?

In that regard, said Hayes, it is relevant to ask whether Chemistry can be a doorway or a barrier. There are in fact a lot of barriers for life happening spontaneously, he says. It is the reason the scientific community is spending a lot of money on Chemical Origins of Life InitiativesChemistry is the current battleground in origin studies.

Hayes believes, however, that without a Creator, there are too many knowledge gaps. For instance, the invisible chemical makeup of our planet is a finely tuned mixture of molecules that supports life, he says, before asking, How did this happen?

Educational Materials

Hayes believes that we need a renewed study of the overlooked components that make up our world in light of Scripture. Science can enhance our relationship with God, he notes as he quotes Jeremiah 29:13, where God says, And you will seek Me and find Me, when you search for Me with all your heart.

Now Hayes is willing to put money where his mouth is. In partnership with the communication ministry Hart Research Institute, and artist Nathan Greene, he is working on seven sets of educational materials based on the seven days of the Creation story. Greene will contribute with one specific painting for each day of Creationhe is currently working on his 5th-day paintingwhile Hayes will provide content for study and discussion.

Each set will include a video, targeting a key element of that specific Creation day, says Hayes. The idea is to throw out important arguments to make people think. It is expected that when availablemost likely by late 2018these materials may be widely used in Adventist schools, churches, and homes.

Our goal is to offer visually compelling artwork, as well as age appropriate educational materials, says Hayes. Instead of destroying our relationship with God, [we believe] science can greatly enhance it!

Air and Water

While Hayes believes that every day of the Creation story has an impressive potential for discussion and reflection on God as the Designer, his presentation is mostly devoted to one of them.

Take the second day, for instance, he says. You can discuss not only the impressive design of the atmosphere but also the magnetic and the electric fields.

Hayes notes that the atmosphere is so finely tuned that one cannot but wonder whether there is evidence of chemical design in the amount of air on the Earth.

Much of the greenhouse effect we are experiencing results from carbon dioxide, which has gone up from 0.035 to 0.040, he says. That small change is producing grave alterations. And the same applies to the weight of the atmosphere, which is exactlyno more, no lessthe one needed to support life on the planet.

After simple but alluring experiments to demonstrate some of the properties of air, Hayes reminds people attending his seminar that atmosphere is a great shield, as it protects Earth from asteroid impacts.

And it is just with the right pressure, he says, explaining that more air pressure would increase the boiling point, making it harder for evaporation to take place and affecting the water cycle. Less pressure, on the other hand, would overheat the planet, since water vapor is a greenhouse gas.

Water is the single most important ingredient for life, says Hayes. But the amount of air controls the water cycle.

As the seminar concludes, and in case people listening to his presentation still entertain doubts, Hayes reiterates his main point.

The creation story from a chemical perspective makes perfect sense, and the Bibles Creation story is scientifically sound, he says. Gods signature is His creation.

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3 Stories: Marijuana And The NFL, Baseball Chemistry, Headwear … – WBUR

wbur Marijuana remains on the NFL's list of banned substances. (Timothy A. Clary/Getty Images)

Several states have legalized recrational marijuana in recent years, but the drug is still on the NFL's list of banned substances. Now, some argue it could be a beneficial alternative to painkillers for players.

That story and more on this week's edition of "3 Stories You Should Know." Patrick Hruby of Vice Sports and Cindy Boren of the Washington Post joined Bill Littlefield.

1. NFL's Banned Healing Component

A recent Washington Post articledetails how some retired NFL players are now experimenting with medical marijuana instead of traditional painkillers to ease football-related pain. Cindy Boren has been following the debate over whether active players should be allowed to use the drug as well.

Players are playing a game that's incredibly painful, so they're looking for anything. And the NFL over the years has pushed prescription drugs, Toradol for instance. And these have long-range effects that really wreak havoc on the system. And players are turning, increasingly, to marijuana. And this is a new science, but it's being shown to have an effect on alleviating pain. ... If you care about the people, then you're going to want what would be the safest way for them to seek pain relief.

2. The 'Science' Of Team Chemistry

Baseball is a statistics-driven sport. But a recent Slate article suggests that team chemistry could become the next hot statistic. Should teams really use math to optimize team chemistry and win more games? Bill Littlefield weighs in.

I think I hate this idea it's too new for me to be completely sure. But some matters, it seems to me, should remain subjective, even in a game so thoroughly drenched in statistics as baseball is. ... What fun it would be to be a fly on the wall when an agent comes into negotiations and says 'Look at these stats that show that my guy is gonna make your whole team so much better just by being a terrific influence in the clubhouse.' I can't wait to hear the response to that.

3. Religious Headwear Allowed On FIBA Courts

The International Basketball Federation (FIBA) announced Tuesday that it would change its uniform rule which banned players from wearing religious head coverings on the court. As of October 1, 2017, playerswillbe allowed to don this headwear. Patrick Hruby likes the move.

It's a pretty significant move, because before this, players with strong religious beliefs didn't have any options. ... But when you look at the change, it does raise the question which is why was this even a rule in the first place? FIBA says this was a "safety precaution." But, there's no actual evidence that any player was ever hurt during a game because of headgear.

More Stories You Should Know

This segment aired on May 6, 2017.

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3 Stories: Marijuana And The NFL, Baseball Chemistry, Headwear ... - WBUR

Evan Engram, Davis Webb Developing Chemistry – G-Men H.Q.

May 12, 2017; East Rutherford, NJ, USA; New York Giants rookie draft class general manger Jerry Reese running back Wayne Gillman (30), quarterback Davis Webb (5) defensive tackle Dalvin Tomlinson (94) head coach Ben McAdoo defensive end Avery Moss (91) tight end Evan Engram (88) and offensive tackle Adam Bisnowaty (66) at Quest Diagnostics Training Center . Mandatory Credit: William Hauser-USA TODAY Sports

NFC East Buzz: New York Giants lost ground in draft by Curt Macysyn

New York Giants: Team needs to manage the Webb hype by Curt Macysyn

The New York Giants utilized the 2017 NFL Draft to address two of the biggest needs on the roster. The decisions may have come as something of a surprise, but New York filled the voids at tight end and quarterback.

With Evan Engram on pace to earn astarting role in 2017, and Davis Webb projected to be Eli Mannings successor, the new duo iswasting no time in developing chemistry.

New York selected Engram in the first round andWebb in the third round of the 2017 NFL Draft. Both selections offered a fair indication of how important they are to general manager Jerry Reeses vision for the team.

According to Jordan Raanan of ESPNs NFL Nation, the chemistry between Engram and Webb has been building since the Senior Bowl.

Its funny because Evan was my favorite player at the Senior Bowl. I told him that there, Webb said Friday after the first day of rookie minicamp practice. Couple months later, were on the same team. So that is really cool. Evan is a great player. He works his butt off. He did a great job [Friday] with his assignments and is coached really well. We have a good relationship off the field, and hopefully that translates to a good relationship on the field.

its far too soon to jump to any concrete conclusions, but Engram and Webb could be anchoring the Giants offense for years to come.

Engram is a 63 and 234-pound tight end with 4.42 speed and proven playmaking ability. He led all FBS tight ends in yards per reception during the 2014 season, and recorded 65 receptions for 926 yards and eight touchdowns during the 2016 campaign.

The Giants have long needed a tight end who can stretch the field vertically, and Engram has the potential to be a matchup nightmare.

As for Webb, hes filling the biggest shoes of all as Mannings heir apparent.

Webb is a 65 and 229-pound quarterback whoput up 4,295 passing yards, 37 passing touchdowns, 12 interceptions, and eight rushing touchdowns in 2016. He completed 61.6 percent of his passes, but theres a rational fear that he may havelearned bad habits in spread offenses.

Thankfully, Webb projects to have two or three seasons to learn behind a Super Bowl champion.

The New York Giants havethe potential for greatness. Both Evan Engram and Davis Webb will play roles in the development of it.

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Evan Engram, Davis Webb Developing Chemistry - G-Men H.Q.

Chemistry professor receives NSF CAREER Award – KU Today

LAWRENCE A question that has eluded scientists for 200 years will be the object for study for a University of Kansas chemistry professor who received a prestigious award from the National Science Foundation.

Marco Caricato, assistant professor in the Department of Chemistry, was awarded a Faculty Early Career Development (CAREER) Award from the National Science Foundation for his research proposal First Principles Evaluation of Optical Activity in Solids. The award is the highest honor given by the NSF to young researchers.

Caricato will focus on chiral solids and their interaction with light, an effect known as optical activity. Chiral molecules and solids are objects that are nonsuperimposable mirror images of each other, such as right and left hands. Chiral molecules and supramolecular systems also play an important role in biology, as proteins and DNA are made out of chiral molecules (amino acids and sugars), and life has evolved around only one of the two possible mirror images (called enantiomers) for these molecules. Therefore, it is extremely important to be able to distinguish which enantiomerthat researchers have in their samples (for drugs, only one enantiomer will be effective, while the other may even be dangerous).

One way to distinguish these mirror images is through their interaction with chiral light. Scientists have studied optical activity in chiral molecules and crystals for 200 years, and they are able to use this interaction effectively for sample analysis. Nevertheless, scientists have yet to understand the correlation between molecular structure and the electronic response to light. In other words, it is not possible to predict the magnitude and sign of the response by simply looking at the microscopic structure of the material.

It is exciting to study a phenomenon that is still not quite well understood after so much time from its discovery. We are going to use sophisticated computer simulations to try to gain a chemically intuitive understanding of such structure-property relationship of matter, Caricato said.

This project could have implications for materials science, as well. Chiral materials are becoming increasingly popular for applications in catalysis, molecular recognition and electronics. Caricato will use theoretical simulations to develop first principles quantum mechanical methods for the calculation of optical rotation.

Caricato will receive $625,000 over the next five years to support his research as well as an outreach program to bring computational chemistry into high school classrooms in Kansas.

With this award, the Department of Chemistry now counts 14 CAREER Award recipients in its current faculty, reflecting a notably high success rate in applications for this award.

Professor Caricato's state-of the art research in using quantum chemistry to explain and predict the properties of materials complements very well KU's already strong efforts in computational chemistry, said Brian Laird, chair of the Department of Chemistry. This well-deserved award is a testament to the high level of research productivity that he brings to the department and to KU.

Caricato joined the university in 2014. He served as a postdoctoral fellow at Yale and a research scientist at Gaussian Inc. following the completion of his doctorate at Scuola Normale Superiore in Pisa, Italy, in 2006.

The NSF has existed since 1950 to promote discovery in the sciences and to fund those on the frontier of scientific innovation. The NSF CAREER Award supports junior faculty who engage in outstanding research, education and integration of education and research in their academic roles.

The Department of Chemistry is in the College of Liberal Arts & Sciences, which is KUs largest, most diverse academic unit.

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Chemistry professor receives NSF CAREER Award - KU Today

Plot twist in methane mystery blames chemistry, not emissions, for … – Science News

A recent upsurge in planet-warming methane may not be caused by increasing emissions, as previously thought, but by methane lingering longer in the atmosphere.

Thats the conclusion of two independent studies that indirectly tracked concentrations of hydroxyl, a highly reactive chemical that rips methane molecules apart. Hydroxyl levels in the atmosphere decreased roughly 7 or 8 percent starting in the early 2000s, the studies estimate.

The two teams propose that the hydroxyl decline slowed the breakdown of atmospheric methane, boosting levels of the greenhouse gas. Concentrations in the atmosphere have crept up since 2007, but during the same period, methane emissions from human activities and natural sources have remained stable or even fallen slightly, both studies suggest. The research groups report their findings online April 17 in Proceedings of the National Academy of Sciences.

If hydroxyl were to decline long-term, then it would be bad news, says Matt Rigby, an atmospheric scientist at the University of Bristol in England who coauthored one of the studies. Less methane would be removed from the atmosphere, he says, so the gas would hang around longer and cause more warming.

The stability of methane emissions might also vindicate previous studies that found no rise in emissions. The Environmental Protection Agency, for instance, has reported that U.S. emissions remained largely unchanged from 2004 to 2014 (SN Online: 4/14/16).

Methane enters the atmosphere from a range of sources, from decomposing biological material in wetlands to leaks in natural gas pipelines. Ton for ton, that methane causes 28 to 36 times as much warming as carbon dioxide over a century.

Since the start of the Industrial Revolution, atmospheric methane concentrations have more than doubled. By the early 2000s, though, levels of the greenhouse gas inexplicably flatlined. In 2007, methane levels just as mysteriously began rising again. The lull and subsequent upswing puzzled scientists, with explanations ranging from the abundance of methane-producing microbes to the collapse of the Soviet Union.

Those proposals didnt account for what happens once methane enters the atmosphere. Most methane molecules in the air last around a decade before being broken apart during chemical reactions with hydroxyl. Monitoring methane-destroying hydroxyl is tricky, though, because the molecules are so reactive that they survive for less than a second after formation before undergoing a chemical reaction.

Neither study can show conclusively that hydroxyl levels changed, notes Stefan Schwietzke, an atmospheric scientist at the National Oceanic and Atmospheric Administrations Earth System Research Laboratory in Boulder, Colo. The papers nevertheless add a new twist in explaining the mysterious methane rise, he says. Basically these studies are opening a new can of worms, and there was no shortage of worms.

Despite being conducted by two separate teams one headed by Rigby and the other by atmospheric scientist Alex Turner of Harvard University the new studies used the same roundabout approach to tracking hydroxyl concentrations over time.

Both teams followed methyl chloroform, an ozone-depleting substance used as a solvent before being banned by the Montreal Protocol. Like methane, methyl chloroform also breaks apart in reactions with hydroxyl. Unlike methane, though, emission rates of methyl chloroform are fairly easy to track because the chemical is entirely human-made.

Examining methyl chloroform measurements gathered since the 1980s revealed that hydroxyl concentrations have probably wobbled over time, contributing to the odd pause and rise in atmospheric methane concentrations. But to know for sure whether hydroxyl levels varied or remained steady, scientists will need to take a more detailed look at regional emissions of methane and methyl chloroform, Rigby says.

Why hydroxyl levels might have fallen also remains unclear. Turner and colleagues note that the ban on ozone-depleting substances like methyl chloroform might be the cause. The now-recovering ozone layer (SN: 12/24/16, p. 28) blocks some ultraviolet light, an important ingredient in the formation of hydroxyl. Identifying the cause of the hydroxyl changes could help climate scientists better predict how methane levels will behave in the future.

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Plot twist in methane mystery blames chemistry, not emissions, for ... - Science News

Green Chemistry Conferences | Chemistry Conferences …

Sessions/Tracks

ConferenceSeries Ltdinvites all the participants from all over the world to attend 4th International Conference on Past and Present Research Systems of Green Chemistry during October 16-18, 2017 in Atlanta, USA. This includes prompt keynote presentations, Oral talks, Poster presentations and Exhibitions.

Green Chemistry Conference will be a multidisciplinary gathering and present major areas such as Green Catalysis, Green Chemistry Applications, Green Synthesis and Designing,Green Nanotechnology,Green Chemical Solvents, Analytical Methodologies, Green Nanotechnology, Organo catalysis, Ionic liquids, Green engineering,Renewable energyand many more. The forum of Scientists, students and researchers from all corners of the globe, come together to discuss future science. Each session of the meeting will be included with expert lectures, poster and discussions, join us to designsustainable developmentprocesses, innovations by which and how these strategies drive new policies, advances the business and human health protection. We are glad to invite you on behalf of organizing committee to join us, where you are the decision maker for future.ConferenceSeries LtdOrganizes 1000+ConferencesEvery Year across USA, Europe & Asia with support from 1000 morescientificsocietiesand Publishes 700+Open access Journalswhich contains over 30000 eminent personalities, reputed scientists as editorial board members. To know more about theconference seriesvisit:http://www.conferenceseries.com/

Track 1:Green Catalysts

Catalystscan be divided into two main types - heterogeneous and homogeneous. In a heterogeneous reaction, the catalyst is in a different phase from the reactants. In a homogeneous reaction, the catalyst is in the same phase as the reactants.

You might wonder why phase differs from the term physical state (solid, liquid or gas). It includes solids, liquids and gases, but is actually a bit more general. It can also apply to two liquids (oil and water, for example) which don't dissolve in each other. You could see the boundary between the two liquids.

Heterogeneous catalysis: This involves the use of a catalyst in a different phase from the reactants. Typical examples involve a solid catalyst with the reactants as either liquids or gases.

Homogeneous catalysis: This has the catalyst in the same phase as the reactants. Typically everything will be present as a gas or contained in a single liquid phase.

Track 2:Green Chemistry Applications

In 2005, the Nobel Prize inchemistrywas awarded for the discovery of a catalyticchemical processcalled metathesis which has broad applicability in thechemical industry. It uses significantly less energy and has the potential to reduce greenhouse gas emissions for many key processes. The process is stable at normal temperatures and pressures, can be used in combination with greener solvents, and is likely to produce less hazardous waste.

In 2012, Elevance Renewable Sciences won the PresidentialGreen ChemistryChallenge Award by using metathesis to break down natural oils and recombine the fragments into high-performance chemicals. The company makes specialty chemicals for many uses, such as highly concentrated cold-water detergents that provide better cleaning with reduced energy costs.

Track 3:Green Synthesis-Designing the Starting Materials

There is currently considerable interest in applying the principles ofgreen chemistryandsustainabilityto industrialorganic synthesis, particularly in the fine chemicals and pharmaceuticals industries.

In any synthesis of a target molecule, the starting materials that are made to react with a reagent under appropriate conditions. Before coming to a final decision, consider all the possible methods that can give the desired product. The same product can also be obtained by modifying the conditions. The method of choice should not use toxic starting materials and should eliminate by-products and wastes. Following are some of the important considerations.

Track 4:New Trends inGreen Chemistry

Sustainable andGreen Chemistryin very simple terms is just a different way of thinking about how chemistry andchemical engineeringcan be done. Over the years different principles have been proposed that can be used when thinking about the design, development and implementation of chemical products and processes. These principles enable scientists and engineers to protect and benefit the economy, people and the planet by finding creative and innovative ways toreduce waste, conserve energy, and discover replacements for hazardous substances.

Green chemistrycan also be defined through the use of metrics. While a unified set of metrics has not been established, many ways to quantify greener processes and products have been proposed. These metrics include ones for mass, energy, hazardous substance reduction or elimination, and life cycleenvironmental impacts.

Green Chemistryis the utilization of a set of principles that reduces or eliminates the use or generation of hazardous substances in the design, manufacture and applications of chemical products.

Principles of Green Chemistry:

Track 5:Green Chemical Solvents

The use of hazardous and toxic solvents in chemical laboratories and the chemical industry is considered a very important problem for the health and safety of workers and environmental pollution.Green Chemistryaims to change the use of toxic solvents with greener alternatives, with replacement and synthetic techniques, separation and purification which do not need the use of solvents.

One of principles of Green Chemistry is to promote the idea of greener solvents (non-toxic, benign toenvironment), replacement in cases that can be substituted with safer alternatives, or changes in the methodologies of organic synthesis, when solvents are not needed.

Track 6:Green Metrics and Measurements

Quantifying theenvironmentalimpactof chemical technologies and products, and comparing alternative products and technologies in terms of their greenness is a challenging task. In order to characterize various aspects of a complex phenomenon, a number of different indicators are selected into a metric.Green Chemistry conferenceoutlines fundamental developments inchemistryand chemical technology that have led to the development ofgreen chemistry, green chemical technology, and sustainable chemical technology concepts, and provide a foundation for the development of the corresponding metrics. It includes different approaches to metrics, and case study examples of their applications, and problems in practice.

Track 7:New Ideas for Non Toxic By-Products

Clean technology includes recycling,renewable energy(wind power, solar power,biomass, hydropower, biofuels, etc.), information technology, green transportation, electric motors,green chemistry, lighting, Greywater, and many other appliances that are now more energy efficient. It is a means to create electricity and fuels, with a smaller environmental footprint and minimizepollutionto make green buildings, transport and infrastructure both more energy efficient and environmentally benign. Environmental finance is methods by which new clean technology projects that have proven that they are "additional" or "beyond business as usual" can obtain financing through the generation of carbon credits. A project that is developed with concern for climate change mitigation (such as a Kyoto Clean Development Mechanism project) is also known as a carbon project.

Track 8:Organic Synthesis Based on Multiphase Operation

Organic synthesis is a special branch of chemical synthesis and is concerned with the construction of organic compounds via organic reactions. Organic molecules often contain a higher level of complexity than purely inorganic compounds, so that the synthesis of organic compounds has developed into one of the most important branches oforganic chemistry. There are several main areas of research within the ge
neral area of organic synthesis: total synthesis, semi synthesis, and methodology.

A total synthesis is the complete chemical synthesis of complex organic molecules from simple, commercially available (petrochemical) or natural precursors. Total synthesis may be accomplished either via a linear or convergent approach. In alinear synthesisoften adequate for simple structures several steps are performed one after another until the molecule is complete. The chemical compounds made in each step are called synthetic intermediates. For more complex molecules, a different approach may be preferable: convergent synthesis involves the individual preparation of several "pieces" (key intermediates), which are then combined to form the desired product.

Track 9:Industrial Applications of Green Chemistry

In the past, the industrial production of Adipic acid used benzene as a starting material. Benzene is one of the basic chemicals for industrial reactions and a solvent. It is known that derives mainly from the refining processes of the petrochemical industry. Benzene is also known for its carcinogenic properties (it causes leukemia to highly exposed workers). Afterwards the starting material became cyclohexanone or a mixture of cyclohexanone and cyclohexanol. For the oxidation process it was used nitric acid, producing toxic fumes of nitric oxides, NOx, which are also contributors to the greenhouse effect and the destruction of the ozone layer in the stratosphere. It was Inevitable that the method had to be changed again with more environmentally benign reactions.

Track 10: Analytical Methodologies

Ananalytical methodoranalytical techniqueis a method to determine the concentration of a chemical compound or element in a sample. There is a very wide variety of methods used for analysis which afford different degrees of sample preparation and instrumentation.

Track 11:Sustainability and Environmental Safety

At the global scale and in the broadest sensesustainability andenvironmental safetymanagement involves managing the oceans, freshwater systems, land and atmosphere, according to sustainability principles.

Land use change is fundamental to the operations of the biosphere because alterations in the relative proportions of land dedicated to urbanization,agriculture, forest, woodland, grassland and pasture have a marked effect on the global water, carbon and nitrogen biogeochemical cycles. Management of the Earth's atmosphere involves assessment of all aspects of the carbon cycle to identify opportunities to address human-induced climate change and this has become a major focus of scientific research because of the potential catastrophic effects onbiodiversityand human communities. Ocean circulation patterns have a strong influence on climate and weather and, in turn, the food supply of both humans and other organisms.

Track 12:Green Chemistry and Engineering

Green engineering approaches the design of products and processes by applying financially and technologically feasible processes and products in a manner that simultaneously decreases the amount of pollution that is generated by a source, minimizes exposures to potential hazards (including reducing toxicity and improved uses of matter and energy throughout the life cycle of the product and processes). In so doing, the overall health and ecological stress and risk are reduced. As such,green engineeringis not actually an engineering discipline in itself, but an overarching engineering framework for all design disciplines.

Track 13:Green Nanotechnology

Green nanotechnology refers to the utilization ofnanotechnologyto upgrade the ecological supportability of procedures delivering negative externalities. It additionally alludes to the utilization of the results of nanotechnology to improve manageability. It incorporates making green nano-items and utilizing nano-items as a part of backing of maintainability.

Green nanotechnologyhas been portrayed as the advancement of clean advances, "to minimize potential natural and human wellbeing dangers connected with the assembling and utilization of nanotechnology items, and to support supplanting of existing items with new nano-items that are all the more ecologically agreeable all through their lifecycle.

Track 14:Green Materials and Marketing

Green marketing is the showcasing of items that are dared to be naturally desirable over others. Thusgreen marketingjoins an expansive scope of exercises, including item adjustment, changes to the generation process, economical bundling, and in addition altering publicizing. Yet characterizing green promoting is not a straightforward assignment where a few implications cross and repudiate one another; a sample of this will be the presence of shifting social,naturaland retail definitions appended to this term. Other comparable terms utilized are ecological advertising and environmental showcasing.

Green, ecological and eco-marketing are a piece of the new advertising methodologies which don't simply refocus, modify or upgrade existing promoting thinking and practice, however try to challenge those methodologies and give a generously alternate point of view. In more detail green, natural andeco-marketinghave a place with the gathering of methodologies which look to address the absence of fit between promoting as it is as of now drilled and the biological and social substances of the more extensive advertisingenvironment.

After a Successful conference of Green Chemistry2016, ConferenceSeries Ltd proudly announces the 4th International Conference on Past and Present Research Systems of Green Chemistry during October 16-18, 2017 in Atlanta, USA. This includes prompt keynote presentations, Oral talks, Poster presentations and Exhibitions.

The scientific program andworkshopswill focus on current advances in the research and use of Green Chemistry with the whole concept of this advanced technology is to agendize from past, analyze the present and implement for the future the latest innovative evolving theories and technologies to surpass the hurdles and make modish frontiers.ConferenceSeries LLCOrganizes 1000+ConferencesEvery Year across USA, Europe & Asia with support from 1000 more scientificsocietiesand Publishes 1000+Open access Journalswhich contains over 50000 eminent personalities, reputed scientists as editorial board members. To know more about theconference seriesvisit:http://www.conferenceseries.com/

Green Chemistry Conferencewill be a multidisciplinary gathering and present major areas such as green synthesis,green catalysis, education and policies. The forum of Scientists, students and researchers from all corners of the globe, come together to discuss future science. Each session of the meeting will be included with expert lectures, poster and discussions, join us to designsustainable developmentprocesses, innovations by which and how these strategies drive new policies, advances the business and human health protection. We are glad to invite you on behalf of organizing committee to join us, where you are the decision maker for future.

Green Chemistry Conference purpose is to fill your head with knowledge you can use: ideas, new trends, amazing ingenuity. Our focus is on sustainable Development and Green Technologies, which we believe are foundational to the success of individual organizations as well as our cities, states, nations and world. Attendees come to Green Chemistry Conference to learn from experts in their community and leave.

Every year over 300 of experts representing renewable energy companies, technology and service providers, governments, investors and consultants attend our Green Chemistry Conferences.

With so much to see and do, you can't miss the excitement and energy of Green Chemistry Conference in Atlanta, USA.

The global chemical industry is expected to grow from $4 trillion to $5.3 trillion by 2020. According to a 2011 report from Pike Research, Green Chemistry represents a market opportunity that will grow dram
atically from $2.8 billion in 2011 to $98.5 billion by 2020. The same report also estimates that Green Chemistry is forecast to save industry $65.5 billion by 2020. a part of the $5.3 trillion US chemical industry.

About the Conference:

Green Chemistry 2017 takes immense pleasure to invite you all to be a part of this meeting which will focus on current trends and emerging issues in Green Chemistry. This ConferenceSeries Ltd Conference desideratum is to render an intriguing forum and vibrant opportunity for researchers to share their original research results and practical experiences, at the same time absorb knowledge from works being done around the nooks of world. Apart from researchers, professors, biopharmaceutical industry practitioners, private and public investors, and students are also most welcome to get themselves inbuilt to the rays of novel happenings onGreen Chemistryaround the globe. The whole concept of this advanced technology is to agenized from past, analyze the present and implement for the future the latest innovative evolving theories and technologies to surpass the hurdles and make modish frontiers.

The major objective of the conference is to emphasize the importance of Green Chemistry, explore recent advancements, and research by making room to experts and researchers from around the globe. The gathering will address sustainable developments in areas such as organic chemistry, novel methodologies in physical and applied chemistry. This event will be the best venue for academicians, researchers and interested parties to discuss proposals and most sound issues related to eco-friendly chemical processes.

For more details please visit-http://greenchemistry.conferenceseries.com/organizing-committee.php

Importance & Scope:

Green Chemistry provides a unique forum for the publication of innovative research on the development of alternative sustainable technologies. With a wide general appeal, Green Chemistry publishes urgent communications and high quality research papers as well as review articles. The scope of Green Chemistry is based on, but not limited to, the definition proposed. Green chemistry is the utilization of a set of principles that reduces or eliminates the use or generation of hazardous substances in the design, manufacture and application of chemical products. Green Chemistry is at the frontiers of this science and publishes research that attempts to reduce the environmental impact of the chemical enterprise by developing a technology base that is inherently non-toxic to living things and the environment. Green chemistry is the design of chemical products and processes that reduce or eliminate the use and generation of hazardous substances.

The meeting will be a multidisciplinary gathering and present major areas such as green synthesis, catalysis, education and policies. The forum of Scientists, students and researchers from all corners of the globe, come together to discuss future science. Each session of the meeting will be included with expert lectures, poster and discussions, join us to design sustainable processes, innovations by which and how these strategies drive new policies, advances the business and human health protection. We are glad to invite you on behalf of organizing committee to join us, where you are the decision maker for future.

Why Atlanta?

The city is one of the top three leading destinations in the United States for conventions, business, and meetings. Las Vegas prides itself in being one of the busiest cities in America for conferences and conventions. There are several Green Chemistry Universities in USA. Mainly it includes Yale Universitywhich is the center for Green Chemistry.

Conference Highlights:

Why to attend???

Meet Your Target Market with three days of programming, the Green Chemistry 2017 conference will feature 52 technical sessions, a poster session, green exhibit hall, and keynotes lectures. As the longest running green chemistry conference in the United States, Green Chemistry 2016 invites scientists, decision-makers, students, and chemists to come together, compare findings, and discuss the science of the future. Share your research with an engaged audience of your peers from around the globe; learn from scientific trailblazers who are designing more sustainable chemistries and processes; find out how green innovations are inspiring new businesses and product lines.

A Unique Opportunity for Advertisers and Sponsors at this International event:

http://greenchemistry.conferenceseries.com/sponsors.php

Major Marketing Associations around the Globe

Society of Environmental Toxicology and Chemistry (SETAC)

Major MarketingAssociations in USA

Statistical Analysis of Associations and Societies

Target Audience:

The target audience is Nobel laureates, MD/Presidents, Vice Presidents, Departmental Head & Chairs. Vendors will have the opportunity to introduce the latest Green Chemistry technology to a diverse audience by becoming a conference sponsor via exhibits and/or workshops.

Target Audience:

Top Universities in USA:

Glance at Market of Green Chemistry:

The global chemical industry is expected to grow from $4 trillion to $5.3 trillion by 2020. According to a 2011 report from Pike Research, Green Chemistry represents a market opportunity that will grow dramatically from $2.8 billion in 2011 to $98.5 billion by 2020. The same report also estimates that Green Chemistry is forecast to save industry $65.5 billion by 2020. A part of the $5.3 trillion US chemical industry.

Green Chemistry 2016

Thanks to all of our wonderful speakers, conference attendees and Ad sponsors, Green Chemistry 2016 Conference was our best ever!

The 3rd International Conference on Past and Present Research Systems of Green Chemistry, hosted by the Conference Series LLC was held during September 19-21, 2016 at Embassy Suites Las Vegas, Las Vegas, USA.

The conference attracted the research community, universities and Green Chemistry associations. 13 different tracks and 68 sessions were designed under the theme Emphasis on Emerging Global Trends in the Direction of Sustainability and Environmental Safety. All the sessions, poster presentations invigorated the conference.

Green Chemistry 2016 witnessed an amalgamation of peerless speakers who enlightened the crowd with their knowledge and confabulated on various new-fangled topics related to the field of Green Chemistry.

Green Chemistry 2016 Organizing Committee would like to thank the Moderator of the conference,Dr. Mauricio Rostagno, University of Campinas (UNICAMP), Brazil who contributed a lot for the smooth functioning of this event.

Conference Series LLC would like to convey a warm gratitude to the entire keynote Speakers of Green Chemistry 2016:

Workshop: A workshop organized by Dr. Andrew C Flick, Pfizer Global Research and Development, USA.

Conference Series LLC is privileged to felicitate Green Chemistry 2016 Organizing Committee and Editorial Board Members of Journal of Organic Chemistry: Current Research, Natural Products Chemistry & Research and Journal of Environmental Analytical Chemistry Plenary Speakers, Chairs of the conference whose support and efforts made the conference to move in the path of success.

We thank all the organizing committee members, participants, attendees, exhibitor and media partners for their generous support without which the conference would not have been possible.

Book mark your dates for 4th International Conference onPast and Present Research Systems of Green which will be held during October 16-18, 2017 at Atlanta, USA.

Green Chemistry 2015

Thanks to all of our wonderful speakers, conference attendees and Ad sponsors, Green Chemistry 2015 Conference was our best ever!

The 2nd International Conference on Past and Present Research Systems of Green Chemistry, hosted by the Confer
ence Series LLCwas held during September 14-16, 2015 Hyatt Regency Orlando International Airport, Orlando, USA.

The conference attracted the research community, universities and Green Chemistry associations. 13 different tracks and 68 sessions were designed under the theme Foster Advancements in Globalization of Green Chemistry. All the sessions, poster presentations invigorated the conference.

Green Chemistry 2015 witnessed an amalgamation of peerless speakers who enlightened the crowd with their knowledge and confabulated on various new-fangled topics related to the field of Green Chemistry.

Green Chemistry 2015 Organizing Committee would like to thank the Moderator of the conference,Dr. Dequan Xiao, University of New Haven, USA who contributed a lot for the smooth functioning of this event.

Conference Series LLCwould like to convey a warm gratitude to all the Honorable Guest of Green Chemistry 2015:

The highlights of the conference were its educative and effectual keynote lectures by:

Workshop: A workshop onGreener Fenton processes for removal of persistent organic pollutants from wastewaters organized by Dr. Andreja Zgajnar Gotvajn from University of Ljubljana, Slovenia.

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Green Chemistry Conferences | Chemistry Conferences ...

JPL Team Works Portable Chemistry Lab Detecting Life in the Driest Place on Earth – Pasadena Now

This automated extractor uses water, high pressure and high temperature to release amino acids trapped inside of soil samples. Image Credit: NASA/JPL-Caltech

Few places are as hostile to life as Chiles Atacama Desert. Its the driest place on Earth, and only the hardiest microbes survive there. Its rocky landscape has lain undisturbed for eons, exposed to extreme temperatures and radiation from the sun.

If you can find life here, you might be able to find it in an even harsher environment like the surface of Mars. Thats why a team of researchers from NASA and several universities visited the Atacama in February. They spent 10 days testing devices that could one day be used to search for signs of life on other worlds. That group included a team from Jet Propulsion Laboratory, working on a portable chemistry lab called the Chemical Laptop.

With just a small water sample, the Laptop can check for amino acids, the organic molecules that are widespread in our solar system and considered the building blocks of all life as we know it. Liquid-based analysis techniques have been shown to be orders of magnitude more sensitive than gas-based methods for the same kinds of samples. But when you scoop up a sample from Mars, the amino acids youre looking for will be trapped inside of or chemically bonded to minerals.

To break down those bonds, JPL has designed another piece of technology, a subcritical water extractor that would act as the front end for the Laptop. This extractor uses water to release the amino acids from a soil sample, leaving them ready to be analyzed by the Chemical Laptop.

These two pieces of technology work together so that we can search for biosignatures in solid samples on rocky or icy worlds, said Peter Willis of JPL, the projects principal investigator. The Atacama served as a proving ground to see how this technology would work on an arid planet like Mars.

To find life, just add water

Willis team revisited an Atacama site he first went to in 2005. At that time, the extractor he used was manually operated; in February, the team used an automated extractor designed by Florian Kehl, a postdoctoral researcher at JPL.

The extractor ingests soil and regolith samples and mixes them with water. Then, it subjects the samples to high pressure and temperature to get the organics out.

At high temperatures, water has the ability to dissolve the organic compounds from the soil, Kehl said. Think of a tea bag: in cold water, not much happens. But when you add hot water, the tea releases an entire bouquet of molecules that gives the water a particular flavor, color and smell.

To remove the amino acids from those minerals, the water has to get much hotter than your ordinary cup of tea: Kehl said the extractor is currently able to reach temperatures as high as 392 degrees Fahrenheit (200 degrees Celsius).

Liquid samples would be more readily available on ocean worlds like Jupiters moon Europa, Kehl said. There, the extractor might still be necessary, as amino acids could be bonded to minerals mixed into the ice. They also may be present as part of larger molecules, which the extractor could break into smaller building blocks before analyzing them with the Chemical Laptop. Once the extractor has prepared its samples, the Laptop can do its work.

NASAs own tricorder

The Chemical Laptop checks liquid samples for a set of 17 amino acids what the team refers to as the Signature 17. By looking at the types, amounts and geometries of these amino acids in a sample, its possible to infer the presence of life.

All these molecules like being in water, said Fernanda Mora of JPL, the Chemical Laptops lead scientist. They dissolve in water and they dont evaporate easily, so theyre much easier to detect in water.

The Laptop mixes liquid samples with a fluorescent dye, which attaches to amino acids and makes it possible to detect them when illuminated by a laser.

Then, the sample is injected onto a separation microchip. A voltage is applied between the two ends of the channel, causing the amino acids to move at different speeds towards the end, where the laser is shining. Amino acids can be identified by how quickly they move through the channel. As the molecules pass through the laser, they emit light that is used to quantify how much of each amino acid is present.

The idea is to automate and miniaturize all the steps you would do manually in a chemistry lab on Earth, Mora said. That way, we can do the same analyses on another world simply by sending commands with a computer.

The near-term goal is to integrate the extractor and Chemical Laptop into a single, automated device. It would be tested during future field campaigns to the Atacama Desert with a team of researchers led by Brian Glass of NASAs Ames Research Center in Mountain View, California.

These are some of the hardest samples to analyze you can get on the planet, Mora said of the teams work in the Atacama. She added that in the future, the team wants to test this technology in icy environments like Antarctica. Those could serve as analogs to Europa and other ocean worlds, where liquid samples would be more readily plentiful.

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JPL Team Works Portable Chemistry Lab Detecting Life in the Driest Place on Earth - Pasadena Now

‘Their Finest’ review: Wartime film sizzles with chemistry – The Seattle Times

This utterly charming film set in World War II-era London contains a textbook example of screen chemistry. Rating: 3.5 stars out of 4.

Screen chemistry is an odd thing; often you only notice it when it isnt there. (See: far too many Hollywood romantic comedies.) But Their Finest, an utterly charming film set in World War II-era London, contains a textbook example. Gemma Arterton plays Catrin Cole, a young advertising copywriter hired by the British Ministry of Information to write womens dialogue for wartime propaganda feature films; Sam Claflin is Tom Buckley, a wry fellow screenwriter whos not sure that her presence is necessary. Catrins married, Toms not and so first they become co-workers (he grudgingly admits, eventually, that shes doing a good job), then friends. Watching them, you start noticing how he looks at her like shes a fascinating puzzle that hes trying to figure out, and how she blushes just a bit when hes around, and how effortlessly these two actors convey that they belong together.

Its one of many pleasures in Lone Scherfigs film, based on a 2009 novel by Lissa Evans and drenched in a sweet nostalgia that only very rarely tips into sentimentality. The plots mostly centered on the making of one movie, based on a true incident involving a pair of twin sisters who set out in their fathers shabby boat to help evacuate wounded soldiers at Dunkirk. Its a tale that, as the executives at the Ministry gleefully observe, has everything: Authenticity, optimism and a dog.

We watch the casting process (Bill Nighy, eyebrows perpetually raised, is a delight as a pompous veteran actor), the location shoot (note the 1940s version of CGI), and the way that the filmmakers and cast form an impromptu family. Along the way, were reminded of the new roles that women took on during that time, and how the shadow of war affected every day and every life, even as they soldiered on. And theres one scene, where Sam sits moodily smoking one evening, and Catrin appears behind him as if caught in a moonlit dream, and well, thats why we watch movies, isnt it?

Their Finest, with Gemma Arterton, Sam Claflin, Bill Nighy, Jack Huston, Helen McCrory, Jake Levy. Directed by Lone Scherfig, from a screenplay by Gaby Chiappe, based on the novel Their Finest Hour and a Half by Lissa Evans. 117 minutes. Rated R for some language and a scene of sexuality. Several theaters.

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'Their Finest' review: Wartime film sizzles with chemistry - The Seattle Times

Hopkins, Savage building chemistry – HoustonTexans.com

DeAndre Hopkins and Tom Savage have been teammates for three years. Hopkins was catching passes and touchdowns, while Savage diligently prepared as the backup quarterback each week.

"Thats something everybody in this locker room respects about him," Hopkins said Monday. "How he always stayed into it. How he never got down or never doubted himself.

Savage is now primed for a big opportunity to be the Texans starting quarterback. This offseason, the quarterback-wide receiver tandem has been putting in work in preparation.

"We definitely have been getting after it since weve been back in town," Hopkins said. "Just doing extra things. He throws a good ball. He knows this offense better than any quarterback that can be in this system. Hes been here since hes been in the NFL and under this system, so he knows how to put the ball where it needs to be.

Savage started two games last year and has seen action in other games over the course of his Texans career. While limited in their playing time together on the field, the duo has always been developing chemistry together, according to Hopkins.

We were building that chemistry even when he was on the sideline when he wasnt playing," Hopkins said. "Just him always being into the game and knowing whats going on and knowing what he could do if he was in the game. Even in practice, even in the film room, he was always into it. There was never a time that he didnt know where the ball was supposed to go or how it should be thrown. So, I feel like since hes been here for four years weve been building that chemistry. Not just now.

Savage and Hopkins also developed a friendship along the way. Recently, Hopkins spent time at the Savage house, playing video games and sharing it on his Snapchat. He even joked that he wasnt pleased when the quarterback didnt have his favorite beverage the last time he visited.

But besides that, were pretty tight, Hopkins said, smiling.

This year, Savage and Hopkins will have an opportunity to work together more than ever before. Hopkins, Savage, and the players returned to NRG Stadium on Monday for Phase 1 of the offseason workout program.

The kid is a go-getter," Hopkins said. "He doesnt quit. Even out there today he was trying to be first. He was hustling. He was out there being a leader even though he hasnt played many snaps in this league.

Twitter.com/DeepSlant

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Hopkins, Savage building chemistry - HoustonTexans.com

Bulls’ Three Alphas reunited and reveling in newfound chemistry – Chicago Tribune

Back in late January, nobody could have envisioned the scene from late Tuesday at TD Garden.

Rajon Rondo, Jimmy Butler and Dwyane Wade the Three Alphas descended from their postgame podium session all smiles and serenity. Even away from the spotlight, the questions over, the three players continued talking, first among themselves and then with a growing group of team officials and friends.

In a hallway they exchanged hand-slaps, not unlike the picture Rondo posted to his Instagram account on Jan. 26 of him with Kevin Garnett and Paul Pierce from their shared Celtics championship season.

Rondo's words accompanying that picture, in which he strongly rebuked the decision by Wade and Butler to criticize teammates following a late-game collapse to the Hawks the night before, prompted a team meeting, fines and national negative attention.

For a few days, including the Jan. 27 home loss to the Heat that dropped them to 23-25, the Bulls overtook the Knicks as the league leader in dysfunction.

The Bulls are 20-16 since, including a 2-0 mark in a playoff series that shifts to the United Center for Friday's Game 3. As the Bulls vie to become the sixth No. 8 seed to topple a No. 1 seed in the 68 first-round series since the NBA moved to a 16-team playoffs in 1984, they are emboldened by the fact teams with 2-0 leads in seven-game series are 262-18 (.936) all time.

They also are emboldened by what they have overcome.

"We had adversity as every team has, and that's the thing that's made us closer and stronger together," Wade said. "The credit for this team sticking together through injuries, a trade, through everything, it goes to everyone, from the coaching staff to the leaders to the young guys. Everyone did it together."

This is no fluke lead. The Bulls, led by Robin Lopez, have pummeled the Celtics on the glass and in second-chance points. Butler has outplayed Isaiah Thomas in the battle of stars. And role players such as Bobby Portis in Game 1 and Paul Zipser in Game 2 have delivered steady, heady play.

But perhaps the most encouraging sign for the Bulls is that the Three Alphas played with chemistry and consistency in Game 2. That hasn't been the case for much of the season, even in the Game 1 victory.

And it's doing nothing to slow the growing possibility that, if Wade opts in, the Three Alphas, against all odds, could be back for another season.

"One thing we know about our point guard is he likes everybody to go. He had nine rebounds and when he gets the ball, he's like, 'Go, go,'" Wade said. "We need easy baskets. This is a great defensive team. If we see their half-court defense set up every play, it's going to be hard to score. So our mentality is try to get out and get some easy ones and put some pressure on them."

Wade scored 11 of his 22 points in the fourth quarter of Game 2, he reminded all why even at 35 he has such a powerful playoff pedigree.

After scoring 15 of his 30 points in the fourth quarter of Game 1, Butler stuffed the box score with 22 points, eight rebounds, eight assists and four steals in Game 2. That's greatness.

But Rondo is proving the biggest revelation. Missing out on his 11th career playoff triple double by one rebound, Rondo also had five steals and harassed Thomas effectively enough to limit the need for Butler to guard him, preserving Butler's energy for offense. Avery Bradley said Rondo picked up on the Celtics' poor body language and kept saying on the court that they gave up.

"I just stayed in the gym and worked. I don't think it's anything I've done as far as the mindset," Rondo said of his resurrection from a five-game benching around the New Year. "Before the game, Jimmy and D-Wade kept telling me to shoot and stay aggressive."

Rondo now has career playoff averages of 14.4 points, 6 rebounds, 9.1 assists and 2 steals in 96 games.

"For the playoffs, me in particular, you get a couple of extra days rest for the body," Rondo said. "You get three or four days of prep on a team, lock in to their game plan."

Rondo carries a leaguewide reputation for his preparatory film work and basketball IQ. A common scene in the postgame locker room is for Rondo to call loudly to the video coordinator for an iPad filled with clips he needs to study for the next game.

Wade, who engaged in memorable playoff battles with Rondo when they played for the Heat and Celtics, knows this dynamic well.

"Hated him as a competitor," Wade said. "But that hate is that respect. When we played against Boston back in the day, he knew all the plays. He messes up your first option. And then he knows the second option. We were just good enough to have a third option.

"For me and Jimmy to have someone who is so locked in, that gives us a different voice. Fred (Hoiberg) gives us a voice. We know we can go to (Rondo) and ask anything. He's watching film all the time. It's key to have a point guard like him that controls the whole game. Our job was easy. We just had to play."

It beats bickering.

"We have obviously moved past what happened," Hoiberg said. "They haven't played a lot of games together since Dwyane had the injury (fractured right elbow) and Rajon was inserted back in that starting lineup. They had great chemistry early on in the season. Hopefully it will continue on the rest of the series."

kcjohnson@chicagotribune.com

Twitter @kcjhoop

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Bulls' Three Alphas reunited and reveling in newfound chemistry - Chicago Tribune

Chemistry and cooking collide in a new course at Carlow – Pittsburgh Post-Gazette

For a baker, lemon meringue pie is a tart dessert with an airy foam atop a smooth yellow filling.

For students in Carlows molecular gastronomycourse or maybe even Alton Brown lemon meringue pie is a colloidal system, which involves a gas dispersed in liquid, atop a smooth yellow filling.

Thats because baking is chemistry at its core, explained Monique Hockman,the professor who created the class.

Cooking is pretty much an art, she said.But baking is a science. You truly have to measure things.

The perfect lemon meringue pie is no exception to the rule measuring out the ratio of egg whites to sugar in the foamy meringue is vital in trapping gas bubbles. Similarly, yeast and flour must be proportionate to create the soft, chewy dough for sunshine sweet rolls, a play on traditional breakfast rolls that involves shredded carrots and even carrot baby food.

While baking in a chemistry lab that Ms. Hockman converted into a kitchen complete with toaster ovens under the fume hoods four groups of students dashed around, collecting ingredients for the recipes theyd follow in their lab. Cream of tartar, flour, two containers of raspberries, oranges, lemons, pie crusts, yeast and salt (cleverly labeled NaCl for sodium chloride) lined a table toward the back of the classroom.

Ms. Hockman, who holds a doctorate in physical chemistry from the University of Pittsburgh, said she partially modeled the class from a similar course taught at Harvard University called Science and Cooking, which has been turned into a massive open online course through EdX and adapted for a public lecture series.

Outside the food lab where Ms. Hockmans students create mostly traditional foods, fruit juice caviar, flavored foams, and fruit or vegetable spaghetti noodles are just a few of the wacky creations people imagine when they hear the term molecular gastronomy, she said. However, most chefs who create these visionary and experimental dishes dislike the terminology.

Local chef Kevin Sousa was the first to bring molecular gastronomy to Pittsburgh with his Alchemy menu at Bigelow Grille in the DoubleTree Hotel, Downtown. Among other items, the menu offered tiny, liquefied beads of pierogi with a shot glass of highly concentrated sauerkraut consomme.

He said that molecular gastronomy is a silly term because everything is made of molecules, and all cooking is science.He admits there is a certain specificity associated with what some call molecular gastronomy, but he just calls it modern cooking.

Theres a slightly more scientific approach to it, like why things go together that may not have been thought of before as good pairings, he said.

Ms. Hockman also notes that the term molecular gastronomy is merely the chemistry behind cooking, not necessarily art nouveau in food.

The idea is to achieve the tastes but in different physical states than they normally exist,she said.

In a nearly three-hour class one Wednesday in March, the students tried out four recipes, which appeared drastically different at first. However, each employed a leavening agent, or a substance, which causes expansion in baking.

For Ms. Hockman, the differing culinary approaches with similar scientific functions are what constitute the term molecular gastronomy.

Two of the recipes, sunshine sweet rolls and multigrain cinnamon rolls, used yeast to help the sweet dough rise. The other two recipes, for raspberry foam and lemon meringue pie, relied on cream of tartar to puff up egg whites.

In the breads, biological leavening helps dough to rise, Ms. Hockman told the class. When activated with warm water, biological leavening agents ferment sugars and carbohydrates in flour to release carbon dioxide. Yeast is the most common biological leavening agent, although unpasteurized beer, sourdough starter, buttermilk, kefir and yogurt also use the same mechanism.

The group making cinnamon rolls split up the labor. Biology major Kayla Todd, 19, kneaded the dough. Ms. Todd, of Churchill, donned a white apron with a few squares of the periodic table that spell out Iron Chef, and mixed the dough with her hands until it resembled a ball of cookie dough.

Alternately, her classmates used mechanical leavening to make meringue and foam. In this process, meringue requires cream of tartar or potassium bitartrate which is not a cream at all, but a fine powder.

Students use a stand mixer to whip up egg whites and cream of tartar, which stabilizes air bubbles and keeps the fluffy substance from deflating.The heat and force of the mixing causes the soft peaks to form.

In chemistry terms, the amino acid chains in the egg whites uncoil in a process called denaturation. After they uncoil, they begin to mesh back together again but with pockets of air stuck inside. Adding sugar, as the students did, keeps the gas bubbles from popping.

At the end of class, Ms. Hockman rolled in a cart with a coffee machine and lined up the baked goods on a lab table. The room fell silent as students sampled the fruits of their labor.

Despite the chemistry and hard work, Ms. Todd was, ironically, most concerned with the icing on her cinnamon rolls, which her partner made out of powdered sugar, half-and-half and butter.

Its amazing. You have to taste it, she said, adding,I want to cook now because I hadn't done it at home before.

Courtney Linder: clinder@post-gazette.comor 412-263-1707. Twitter: @LinderPG.

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India’s university chemistry facilities in need of overhaul – Chemistry World (subscription)

A recent explosion at a school laboratory in the eastern Indian state of Oddisha, which injured three students, has drawn attention to the poor laboratory facilities that students face in many of the countrys universities.

India has traditionally fared well in chemistry research. The 2016 Nature Index report, for example, says a rise in chemistry research output was a significant driver of the performance for several research institutions in the top 100 most improved institutions in the index.

But these statistics mask the often poor laboratory infrastructure that most university students have to contend with, unless they attend one of the top-ranking institutions.

Undergraduate teaching chemistry laboratories, particularly in many state universities [] need modernisation, says Krishna Ganesh, professor of chemistry and director at the Indian Institute for Science Education and Research (IISER), Pune. They are very poor from a safety perspective.

Ganesh, who has been calling for more funding for chemistry research, says practical skills in chemistry suffer due to stretched budgets and neglect. There are no or inadequate fume hoods to handle chemicals and students are not trained to wear safety glasses or gloves during experiments, he says. Many labs are also badly designed, without separate emergency exits. India urgently needs to standardise its lab designs, which should include ensuring that each chemistry department has a faculty in charge of safety and basic skills such as fire-fighting and first aid, Ganesh adds.

The safety facilities in most of the Indian Universities are not as good as in western countries, agrees Manoj Kumar Sharma, professor of chemistry at Guru Nanak Dev University, in the northern city of Amritsar. Though most of the labs in India have some first aid kits for minor accidents [they] may not have quality fume hoods. Accidents take place when a student is not attentive while carrying out experiments, or sometimes students do not follow guidelines written on the chemicals.

The root of the problem lies in the general neglect and cut in funds for higher education since the 1990s. H Surya Prakash Rao, professor of chemistry at Pondicherry University in southern India, notes that while chemistry labs in several colleges have been upgraded in the last couple of years due to an influx of m funds from the Ministry of Human Resource Development, the mere availability of laboratories is not enough. There must be generous financial support for chemicals and specialised glassware, he says. Barring a few elite institutions, the majority of Indian universities and colleges do not have the infrastructure for carrying out higher order research.

The neglect of universities is reflected in students experimental skills, says Ganesh, which is often poor compared to theoretical knowledge. He observes that inadequate practical training certainly affects both undergraduate and postgraduate students competence in research and industry jobs. Most students have to be retrained in basic analytical and separation techniques and lab note record keeping, he says. Imparting good laboratory skills and re-equipping them by first undoing their incorrect training [] takes both effort and time.

Undergraduate teaching chemistry laboratories need modernisation. They are very poor from a safety perspective

Krishna Ganesh, IISER

Rao agrees, noting that university research is crumbling due to insufficient funding and lack of accountability, compounded by Indias famed bureaucracy. Over the years, faculty staff are transformed into glorified clerks. They spend lots of time doing administrative jobs rather than spend time on teaching and research, he explains. The result is that students at Indian universities are not being adequately prepared for work industry, as they are in the US and Europe.

India urgently needs modern labs, purposeful curricula with exciting experiments, industry participation in UG/PG courses in university (providing expertise and resources) for lab skill development, and emphasis on safety practical and material hazards, says Ganesh. He adds, however, that India is still managing to do well in chemistry research, despite the overall neglect of universities, because of reasonably good course work in PhD courses and excellent job-oriented training in industries.

Rao points out that the majority of researchers who are doing good research have been trained in top universities abroad. Students and teachers also keep themselves updated with research being carried out in rest of the world, which helps chemistry researchers fare well, adds Sharma. The consensus among academics is that it is not too late for Indias universities to make changes. The priorities must be freeing themselves of red tape, modernising lab facilities and overhauling their approach to teaching.

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How a chemist and a physicist solved a 50-year-old puzzle with help from the Princeton Catalysis Initiative – Princeton University

A quantum physicist was in a quandary.

Nathalie de Leon, an assistant professor of electrical engineering, needed to control the carbon atoms on the surface of a diamond, but the sheer hardness of the diamond was defeating all attempts not just hers, but those of every physicist who had tried over the previous half century.

There was very large graveyard of people who had tried and failed, de Leon said.

Her lab uses quantum technology that depends on point defects in diamonds the result of two carbon atoms being replaced with one nitrogen or silicon atom, leaving a usefully empty space called a vacancy.

Diamond is the hardest naturally occurring mineral because diamonds are made entirely of closely spaced, tightly bonded carbon atoms. Scientists and engineers trying to control the diamond surface have traditionally used harsh methods that also cause subsurface damage, which makes the diamonds useless as the kind of nanoscale sensors de Leon needs.

So she tried something radical. At the inaugural symposium of the Princeton Catalysis Initiative (PCI), she gave a research flash talk an 8-minute introduction to her labs work and along with sharing her teams successes, she mentioned this longstanding problem.

At the next break, she was approached by Robert Knowles, a professor of chemistry de Leon had known from their postdoc days at Harvard.

Rob came up to me and said, The surface chemistry cant be that hard, de Leon recalled. I told him, Well, this is a 50-year-old problem, and nobody has made any progress at all. And then he said, Well, I think we can do it in a year.

He had been working with adamantanes carbon-hydrogen molecules that look like a unit cell of diamond in a field of chemistry that hadnt existed a decade ago, when de Leon got her Ph.D. in chemical physics.

What Rob knew was that a catalyst that they make, that people are famous for around here, had really busted open this field of adamantane chemistry, said de Leon. The reason Rob was so confident that we could do it in a year was that he thought, It just looks like an adamantane! How can this be so difficult?

Knowles believed that he had the key to unlock de Leons problem, but they had another obstacle: funding. To test their hypotheses, de Leon and Knowles would need to reinvent not only surface chemistry, but also come up with a new way to measure the results of their reactions. Federal research organizations balk at using taxpayer dollars for such a long shot.

This was an especially high-risk project we were proposing to do chemistry that no one else had ever done, to do reaction discovery in a hard system, de Leon said.

So they applied for funds from PCI, which encourages unlikely pairings and blue-sky endeavors.

Once PCI gave them the money to get started, de Leon said she and Knowles brought two very courageous graduate students onto the project (Lila Rodgers and Suong Nguyen), and the team ultimately created an entirely new discovery pipeline.

She shared the story during a flash talk two years later, at the third annual PCI symposium on Jan. 23, 2020. Using this pipeline, it did actually just take a year, so Rob was right! she said, to laughter and applause.

Professors Abigail Doyle and David MacMillan explain the role of catalysts and catalysis in the modernworld.

Video by

Danielle Alio, Office of Communications

Working together, the chemist and the quantum physicist had discovered completely new types of chemistry that work at the diamond surface.

Thats par for the course at the Princeton Catalysis Initiative, said David MacMillan, one of the four PCI co-founders and Princetons James S. McDonnell Distinguished University Professor of Chemistry.

The thing PCI is most concerned about in the next 10 years is how do you create or enable new fields of research, MacMillan said. Thats the currency we care about.

To accomplish this, PCI accelerates scientific interactions between researchers, like de Leon and Knowles, both within and beyond the Princeton campus. At the annual symposia, speakers deliver flash talks that resemble a cross between a TED Talk and a research colloquium, in which they sketch out their research interests and any problems for which theyre looking for collaborators. Speakers at the 2020 symposium came from fields as diverse as psychology, economics, electrical engineering and computer science.

Its like speed dating for scientists, said Sabine Petry, an assistant professor of molecular biology. Heres what I have to offer, heres what I need, lets connect. At the first PCI symposium, Petry connected with Howard Stone, the Donald R. Dixon 69 and Elizabeth W. Dixon Professor of Mechanical and Aerospace Engineering. Petry and Stone had already co-advised a graduate student for several years when they heard each others flash talks and realized that they could collaborate on an entirely unrelated problem.

Part of PCIs magic is the long snack and meal breaks built into the day-long symposium, Knowles said. Its great to socialize with people while also concentrating on the science, he said. Ive known Nathalie for years, but weve never talked about our research at this level.

Theres something quite wonderful about the scale of these annual symposiums, said Robert Prudhomme, a professor of chemical and biological engineering. Its the breadth of faculty from across the campus, combined with the chance to hear their research in a concise manner, that is unique. If you think about trying to go to this many research talks under any other circumstances 20 people, times an hour for each seminar it would just never happen.

PCI has sparked and funded two new collaborations for Prudhomme, one with Haw Yang, a Princeton professor of chemistry, and another with researchers at Genentech.

When MacMillan and his colleagues first imagined PCI, they hoped to fund 150 collaborations. To achieve that, the initiative sought financial support from individual donors as well as companies that depend on catalysis. Three years later, with support from Bristol-Myers Squibb, Celgene, Genentech, Genmab, Janssen and Merck, as well as individuals including Tony Evnin and Eric and Wendy Schmidt, PCI can fund more than 500 collaborations over 10 years.

Theres a sweet spot of doing it here at Princeton, because were just the right size, MacMillan said. We have a critical mass, but were not too big or too diffuse. And the other part of it is, our faculty here are very much into being collegial to each other. Were very warm towards wanting to be involved in collaborations. Researchers see the win-win; as opposed to I want to keep this to myself, its more, I want to work with other people around the campus to take this interesting endeavor in new directions.

PCI supports 78 researchers in 11 departments and institutes across the Princeton campus, most of which are clustered together on Washington Road. Clockwise from lower left: Princeton Neuroscience Institute (neuroscience), Peretsman Scully Hall (psychology), Icahn (genomics), Lewis Thomas Laboratory (molecular biology), Guyot (geosciences and environmental sciences), Woodrow Wilson School (public policy), Fine Hall (math), Jadwin Hall (physics), Friend Center (computer science), EQuad (engineering), and Frick (chemistry).

Image courtesy of the Princeton Catalysis Initiative

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How a chemist and a physicist solved a 50-year-old puzzle with help from the Princeton Catalysis Initiative - Princeton University

Mansfield outfielder says chemistry key to team’s success – Fort Worth Star Telegram

Mansfield outfielder says chemistry key to team's success
Fort Worth Star Telegram
I think the season is going well so far, and it has been fun with this team because of the great chemistry we have together and the leadership on this team, Tatrow said. I try to bring a positive energy day in and day out and a fun attitude, but at ...

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Q&A: Chemical Biologist Ken Hsu to Use NSF CAREER Award to Fight Cancer – University of Virginia

A promising University of Virginia scientist, Ku-Lung (Ken) Hsu, an assistant professor of chemistry, has earned one of the National Science Foundations coveted Early Career Development Program Awards, which support junior faculty members who perform outstanding research and are regarded as exceptional teachers.

Part of the grant is used to integrate education and research in academic activities. Hsus award is for $681,000.

Hsu uses chemistry to control biological systems, particularly to modify the immune system to become an active combatant against cancer. His work understanding and controlling the inflammation response spans the search for new non-addictive drug options for treating pain, to modifying immune cells so they can recognize and kill cancer cells.

The five-year NSF CAREER grants are among the most prestigious available to young faculty in science and engineering, and are designed to provide significant resources to the early stage development of careers.

Many of Hsus laboratory studies are conducted in collaboration with clinical researchers in the School of Medicines Cancer Center as part of UVAs efforts to enhance research into precision medicine using immunotherapy to target life-threatening diseases at the fundamental molecular level.

Hsu discusses here his research and grant for readers of UVA Today.

Q. What drew you to this area of chemistry?

A. Chemical biology is an exciting area of chemistry because it is very creative, highly interdisciplinary and allows scientists to answer fundamental questions that ultimately improve human health through drug discovery and other new therapies. I enjoy the opportunity to work with experts in so many different fields, including pharmacology, pathology, neurology and cancer biology. As a result, I learn something new from each project.

My students also benefit greatly from being in this field because of an emphasis on collaborations, which increases diversity through individuals they interact with and expands the skillsets they obtain during their training. Medical research is becoming increasingly collaborative, so my students are becoming well-prepared for the research environments in which they will spend their careers.

Activating the immune response to fight cancer represents a very exciting treatment modality and UVA is well-positioned to be a leader in this front. The UVA Cancer Center has been a major supporter of my research program, and I look forward to continued interactions and collaborations in this community.

- Ken Hsu

Q. Describe the most compelling aspects of your latest research.

A. I am excited about two recent discoveries that embody research from our group in the field of chemical biology. Both reports are published in the journal Nature Chemical Biology.

In our first paper, we describe a new chemical reaction with broad applications for synthetic chemistry and drug discovery. The reaction we discovered possibly could come into common use for developing new treatments for cancer and other diseases in the future. This finding was especially rewarding because I teach related material in my organic chemistry course and our paper describes a new methodology for synthetic chemists and chemical biologists to tune chemical reactions for diverse real-world applications. This is compelling for my students, to know that what they are learning in class is also current and active to catalyze breakthrough research in our labs.

In our second report, our findings are directed toward fundamental discoveries in the realm of fat (lipid) molecules, which play a major role in the bodys metabolism at the cellular level. We used protein engineering to design artificial lipid kinase enzymes a specialized protein involved in cell growth, proliferation and other functions that can include the growth of cancers in order to better understand how cells regulate their fat composition. To our surprise and delight, we narrowed in on a very specific region of these lipid kinases that allow us to control how they operate in cells. Our findings will teach us and others in the field a more effective way to design therapeutics to combat these enzymes when they misbehave.

Q. How will this grant allow you to connect your research with teaching?

A. The NSF CAREER Award will provide new opportunities for applying our chemistry and technologies to study how individual cells control the metabolism of fats and lipids. We plan to develop compounds that attach to enzymes to illuminate how cells are similar or distinct based on their metabolism kind of like a molecular fingerprint. Our long-term goal is to create new opportunities for cell type discovery and push the boundaries of cell engineering.

The research is intimately connected to an educational outreach program designed to broadly impact Native American student communities by providing opportunities for UVA graduate students to teach how lipid biochemistry influences healthy food choices and eating behaviors in society.

Q. Where do you see your research going from here?

A. In the next five years, I am looking forward to applying our chemistry and technologies toward deeper understanding of lipid biology and metabolism in physiologically relevant models. We remain committed to discovery of new molecular pathways for immune system modulation, and our recent findings represent important steps toward our long-term goal.

Q. How promising is the future regarding immune system modulation?

A. Activating the immune response to fight cancer represents a very exciting treatment modality and UVA is well-positioned to be a leader in this front. The UVA Cancer Center has been a major supporter of my research program, and I look forward to continued interactions and collaborations in this community.

I believe the chemistry we are pursuing will provide new opportunities and technologies for exploring creative ways to study and control the immune system. Support from the NSF CAREER Award will pave the way for new ways to engineer immune cells for cancer and other potential disease indications.

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‘To All the Boys’ Sequel Disappoints with Lack of Chemistry, Charm – Georgetown University The Hoya

Despite the captivating romance in To All the Boys Ive Loved Before, its sequel fails to build on the story of the couples new relationship. With an uninspiring relationship and awkward anachronisms, the sequel does not deliver the romance promised by its pre-Valentines Day release.

To All the Boys: P.S. I Still Love You picks up as Lara Jean (Lana Condor) and Peter (Noah Centineo) go on their first date as a new couple. Their romantic bubble is soon popped, however, when John Ambrose (Jordan Fisher), one of Lara Jeans past crushes, comes back into her life, introducing uncertainty into her new relationship. The stereotypical love triangle ensues as teenage jealousy and insecurity escalate relationship tensions.

The lack of romantic chemistry between Lara Jean and Peter leaves the audience unsure whether viewers should root for the couple. Though the couples first date at a romantic restaurant is full of soft lighting and charming ambience, the interaction between the two seems perfunctory. Even with the two sitting feet apart, there is no chemistry when Peter reaches over to kiss Lara Jeans hand. The rest of the date night, though cute, fails to regain the electricity that viewers saw in the first film in 2018.

The depiction of the relationship is further sabotaged as neither protagonist is able to show genuine care for the other. Despite constantly saying that she loves Peter and wants to be with him, Lara Jean nevertheless fails to tell John Ambrose of her relationship status even when he is clearly flirting with her. Her confusion between the two men may be understandable, but her repeated choice to hide her relationship makes the audience question if she really cares about Peter as much as she says.

Peter similarly shows problematic tendencies that undermine the films attempts to portray him as sympathetic to the audience. On Valentines Day, knowing Lara Jean is expecting a grand gesture, Peter only gives her a necklace and reads her an unoriginal poem he passes off as his own. Though he later explains that he only hoped he could write something as good, his lackluster defense does not justify why he did not simply spend more time to come up with a more thoughtful gift.

Peter later fails to pay attention to Lara Jean at a party, only leaving with her after coincidentally noticing her sitting in the corner. His lack of effort in maintaining their relationship does not match his claim about loving Lara Jean, which is a distracting incongruity throughout the film. Halfway through the movie, it seems like even a happily-ever-after would only be lukewarm.

Throughout the movie, anachronisms in the otherwise modern setting make the plot too relatable to young audiences. With Valentines Day featuring stereotypical a cappella group serenades and a carnival date, it seems as though a middle-aged writer was trying too hard to imagine what teenagers do these days. The anachronisms detract from the authenticity of the film and make it even harder for audience members to see themselves in the plot.

One of the few saving graces of the sequel is Kitty (Anna Cathcart), Lara Jeans younger sister. With her witty comments and humorous interruptions, Kitty offers a welcome distraction from otherwise awkward situations with uninteresting dialogue. Her playful relationship with Lara Jean accurately captures the type of banter typical of sisters, adding some much-needed authenticity to the movie.

While To All the Boys: P.S. I Still Love You had potential to build an unforgettable romance following the cheeky previous film, the movie failed to capture the opportunity. Even original fans of the Lara Jean and Peter relationship were left wanting for a reason to root for them again.

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'To All the Boys' Sequel Disappoints with Lack of Chemistry, Charm - Georgetown University The Hoya