30 seconds of a teen astronomer | Bad Astronomy

NOVA Science Now has a nifty feature they’re doing online where they spotlight "The Secret Life of Scientists". I have some reservations about it, because one thing scientists aren’t, is secretive. We talk about what we do constantly.

Anyway, they have a series of short videos about teen astronomer Caroline Moore, who recently discovered a rare type of supernova. She found this supernova, by the way, when she was 14.

They also asked her 10 questions, and while I might disagree with her choice of a news source, I think it’s great that they let her be her, and she shines right through in these videos. It’s also really terrific that she doesn’t compromise in these interviews, belting out whatever is on her mind. She’s a fantastic role model for kids interested in science, showing them that science really is cool, and you can do it and still be you.


PGx in DTCG? Doesn’t stand up to Useful testing.


HT Don Rule today as well as the ENTIRE Pharmacogenomics Advisory Group that I am a proud member of.


Don wrote this comment a few days ago

"I was curious about what SNPs the DTC companies offer so I wrote a little applet (http://snpweb.cloudapp.net/#/PharmGKBSNPs) to compare them to the SNPs in PharmGKB. It turns out the the Cytochromes are particularly sparse."

Well Don, you are correct. Even more so, as we began to review SNP data it became crystal clear on Monday.

The reason I was pissed about 23andMe doing the CF testing is because they missed hundreds of potential carrier alleles. What was even more so angering when I realized, you could be "tested" by one of these DTCG companies for "Plavix Metabolism" and come up with the absolute wrong answer.

Imagine that. Most people turn to DNA for an "absolute call" but when you don't look for the right SNPs or all of the needed SNPs, you miss a whole bunch.

Quick story. I had this pulmonologist physician, an elder statesman, super smart, Ivy league trained come up to me and say "Hey Steve, can you help me out?"

He is a sleep doctor too. He said "I have been trying to test for this narcolepsy gene and I can't get the right answer"

I said "Sure Dr. X, what do you mean 'keep getting the wrong answer'?"

He Said

"Well I am looking for HLA DQB1 and they keep telling me about this HLA DR, I have sent this test 3 times now and still gotten no information about HLA DQB1."

I did a big 'ol face palm.



Instead it searched for an imperfect haplotype......

That's the problem. If you don't test for exactly what you are looking for, you will never find it. Nor will you have the correct clinical answer.

If you only test 2 SNPs for CYP 2C19, you will never be able to accurately predict what someone's metabolizer status is.

What people should be using to assess metabolizer status of medications is something like the DMET Plus with additional PCR or another platform. AmpliChip does a nice job, but we have to be serious when it comes to medical care.

You Cannot, I repeat Cannot take the advice from 23andMe when it comes to metabolizer status for Plavix.

Please, please, please listen to me. Even 23andMe states it on their post about Plavix

This DTCG test is not ready to be used in the clinic or even trusted to tell your metabolizer status. Right now, they are not testing enough SNPs for me to be happy with it and use it in the office.

Don't stop your Plavix! Instead go get a clinical pharmacogenomic test done by someone who understands the limitations of the labs.

That drunk who lost their keys is still looking under the lamposts because that is where the light is..........

That is a stupid way to do clinical pharmacogenomics.

The Sherpa Says: Pretending to be clinical without standing up to clinical rigor is a recipe for disaster. I await the lawsuit from in stent thrombosis for the poor sap that trusts 23andMe enough to stop their Plavix.

The Mightiest Mite: Dung Beetle Is Crowned World’s Strongest Bug | 80beats

dung-beetlesA certain species of dung beetle has been crowned the world’s strongest insect. A male Onthophagus taurus can pull 1,141 times its own body weight — the equivalent of a 70-kilogramme (154-pound) person being able to lift 80 tonnes, the weight of six double-decker buses [AFP]. That power comes in handy not just to roll up a few extra dung-balls, but also to protect mates and stave off potential rivals.

Chronicling the insect’s amazing strength in the journal Proceedings of the Royal Society B, scientists Rob Knell and Leigh Simmons explain that the beetle’s amazing strength is connected to his sex life. These female dung beetles dig tunnels beneath choice pieces of dung in which to lay their eggs. If another male enters a tunnel already occupied by a rival, then the dung beetles duke it out, each male using his immense strength in an attempt to push the other out. Usually, the male that guards the tunnel repeatedly mates with the female inside.

In the study, scientists calibrated the males’ strength by gluing a cotton thread to the beetles’ hard wing-cases, stringing the thread across a pulley, and tying it to a miniature bucket, to which they added drops of water [ScienceNOW]. The dung beetle’s coronation as the world’s strongest insect steals the thunder from the rhinoceros beetle, which can lift up to 850 times its own weight.

The weaker males in this brawny insect community aren’t entirely out of luck, as nature has endowed them with other survival advantages. Knell added that some male dung beetles are smaller and weaker, but do not have to fight for female attention due to their “substantially bigger testicles”. “Instead of growing super strength to fight for a female, they grow lots more sperm to increase their chances of fertilizing her eggs and fathering the next generation” [AFP].

Related Content:
80beats: Female Dung Beetles Evolved Elaborate Horns to Fight for the Choicest Poop
Discoblog: Enough of This S#%t! Dung Beetles Morph into Millipede-Eaters
Discoblog: A Literally Crappy House Protects Beetle Larva From Predators
The Loom: An Inordinate Fondness for Beetle Horns

Image: Alex Wild. Two male dung beetles fight for supremacy. 

Rebecca Sink-Burris Announces a Run for At-Large LNC Seat

Fellow Libertarians,

I am extremely pleased to announce the candidacy of a long-time LPIN activist, candidate and financial supporter for the position of Libertarian National Committee At-Large representative at the upcoming LP Convention at St. Louis.

Rebecca Sink-Burris has been a Libertarian Party member since the 1970’s and has served the LPIN in many capacities including Vice-Chair.  She has also run for U.S. Senate and was instrumental in helping us retain our ballot access when she ran for Secretary of State in 2002 gaining will over 4% of the statewide vote when we were required to gain just 2%.

I would strongly encourage delegates to meet Rebecca at the convention and ask her about the future of the Libertarian Party.

Her message follows:

Having served on the board as an alternate and as a 2 term regional representative for one of our more effective regions, I have seen how damaging it is when board members don’t work well with each other, I want to continue to serve in order to help bridge the gap. I’ve been a Libertarian since the 70’s and have served the party by collecting signatures, taking on leadership positions at state and national level, running for office numerous times, including being the candidate for Indiana’s ballot access race. I am interested in being part of an effective LNC, I value the diversity of ideas within the Libertarian Party and can be counted on to listen to all viewpoints and work with all members respectfully. The emphasis needs to be on getting the job done, or in the words of Elvis ” A little less conversation, a little more action please.”  This is our time, let’s move forward.

Thanks,

Rebecca

UNSUBSCRIBE???

I want to be taken off your email list I do not want any of your email's I am mactheknife stop send me stuff You are a pest and if this doesn't get you stopped I'm going to complane!

Microfractures in Steel Parts

Hello partners, I tray to found a provider of a micro fracture developer liquid.

I know to exist one´s to be fluorescent with ultraviolet light.

please if you know the name of any mark or provider please contact me.

Regards.

Pressure Exerted on a Coating

Hello All

My field is Chemistry and we are doing a test to determine if a concrete garage coating will delaminate or stain when subjected to the hot tires of a vehicle. The test we do is to heat up a piece of tire that is 3 inches by 5 inches and then apply pressure to the tire on top

I Am A Skeptic | Bad Astronomy

Skeptic Magazine’s website has a new feature I like: short bios of important skeptics.

swoopybanner

Daniel Loxton, the creator of this series, also made banners to put a face on skepticism. The face featured here is for the tireless and wondrous and totally awesome Swoopy*, who runs the Skepticality podcast with Derek Colanduno.

I suspect you might recognize some of the others there too. And if you don’t, get to know them! You’ll be happy you did. But don’t believe me. Prove it for yourself.


*MMMMmmmmm, Swooooooopy.


New Review of Unscientific America in Science Communication | The Intersection

Our book reviews aren't over yet--perhaps they will keep coming out all the way to the paperback release date in May. The latest is from David J. Tenenbaum of the University of Wisconsin-Madison, founding feature writer for the WhyFiles, who is reviewing in the journal Science Communication. Tenenbaum begins with a revealing vignette:
I e-mailed an eminent limnologist today, seeking to discuss an environmental issue that he’s considered important enough to study for several years. To my delight, he immediately responded with word that a new study was forthcoming in an important journal. Then, to my dismay, he added that the journal’s embargo would expire a couple of weeks after my publication date.
No problem, I replied. He’d watched the issue develop for years and would surely have a useful comment. Then I got the silent treatment.
Huh? When you contact scientists for a living (I admit, science journalism can seem a branch of telemarketing), you get used to nonresponses, to experts who think a “tight deadline” means 3 months, or are in Mongolia or at an invitation-only conference in Estonia. This latest wrinkle on the rejection letter told me that this expert would be happy to get help publicizing his newest research ...