James Harden and Doc Rivers showed us what its like to build NBA chemistry in training camp – SB Nation

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The Philadelphia 76ers believe they have a championship caliber roster in place entering the 2022-23 season. After swinging a trade deadline deal for James Harden last year, Philadelphia knocked off the Toronto Raptors in the first round, and lost a tough six-game series to the Miami Heat in round two with superstar center Joel Embiid playing through multiple injuries.

The Sixers have now had a full offseason to integrate Harden while spending their summer improving the roster around the margins. This should be one of very best teams in the East, but its going to require Harden to reestablish himself as one of the best guards in the league after a down year by his standards last season. We named him one of nine NBA players with the most to prove entering the new year.

The Sixers certainly have a lot of talent, led by Harden and Embiid, but they will need to find cohesion. That process begins in the preseason. As the Sixers opened training camp, there was a viral video of head coach Doc Rivers coaching up Harden that was so cool to watch.

This is a rare peak behind the curtain of what goes on at NBA practices. Fans are smarter because of access like this, and its a great way to grow the game.

In the clip, Rivers talks to Harden about the need to establish Embiid this season. He says Harden is a team leader, and needs to show everyone else how to get the big man in the middle going.

We were a horrible would you agree? a horrible post passing team last year, Rivers tells Harden. Our objective is getting that first. Thats why you need to have the right spirit about it. Get them to do it right.

What I got to get yall right on is when to roll, when to pop, when you got the ice. You and him, yall got to get a communication where yall listen to each other.

Rivers also pressures Harden to find his own scoring. Harden led the league in scoring for three consecutive seasons by averaging more than 30 points per game when he was in Houston, but his scoring numbers have fallen the last two years. He only put up 21 points per game after being traded to Philly.

We got to get you what you want, Rivers says. You can;t just say youre a facilitator. You need to be a scorer and facilitator. Its going to take time to figure it out. We need you to be the aggressive James you were the last five minutes.

Rivers also tells Harden that the rest of the team must fall in line behind him and Embiid.

We got to establish Joel and you, Rivers says. Theres a pecking order, this aint a democracy.

The Sixers added P.J. Tucker, DeAnthony Melton, and Danuel House over the offseason, and still have Tyrese Maxey, Tobias Harris, Matisse Thybulle, and Paul Reed. This team should be excellent if they can find the chemistry Rivers is seeking. Its so cool to see how that process starts to build.

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James Harden and Doc Rivers showed us what its like to build NBA chemistry in training camp - SB Nation

The Occult Origins of Chemistry and the Stuff of Life The Wire Science – The Wire Science

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Illustration: Daro Mndez/Unsplash

Although it may seem like a modern fantasy, the project of artificially creating a living organism already resounds through the experiments of the ancient alchemists. Long before the birth of modern chemistry, the physician and alchemist Paracelsus, in his 1537 volume De Rerum Natura, describes a bizarre biochemical procedure for the preparation of what he called a homunculus, a synthetic organism with the appearance of a very small human being. Paracelsuss procedure involved the use of certain biological components such as human semen, manure and blood, which, when subjected to a long process of fermentation, would enable the development of an embryo.

While this type of occult operation may seem absurd today, the result of magical superstitions and, in terms of our contemporary view, a fundamental misunderstanding of how life works, such tales of ancient science often contain deeper and more relevant significance than it may seem.

Alchemical lore was based on the idea that the inorganic matter encountered by the alchemist in his laboratory was related to the soul of the human being via a complex of mysterious connections and that it was possible, through scientific investigation, to build a bridge between the chaos of inorganic matter and the harmony of the living body, through experimental work in which chemical transformations were understood to also reflect an inner transformation of the alchemist carrying them out.

I have always been fascinated by the occult origins of chemistry; I think that, although they are not always evident, contemporary chemistry still bears these ancient influences within it. The idea, so dear to alchemists, of a continuity between the inorganic and the organic world, between dead and living matter, was the basis for the development of modern chemistry and still influences many of our technologies today. But in the ancient alchemical legends I believe we also find symbolic confirmation of the idea that, in chemical synthesis, inorganic matter and human beings exert an influence upon one another, forging a fruitful alliance that makes it possible to produce something completely new.

Paracelsuss alchemical procedures, while fascinating, would never have led to any demonstrable result, and yet chemistry, over its long history, has never entirely freed itself from the ambition to discover how to break through from the inanimate realm of dust and crystals to the domain of the living in all its forms.

When Mary Shelley first published Frankenstein anonymously in 1818, contemporary science was at a very delicate point. The veil that divided living organisms from inorganic matter was gradually thinning, bringing life and death into dangerously close proximity; increasingly, a certain unexpected continuity was being established between the study of biological organisms and other areas of science and technology.

We know that in the writing of her novel, Mary Shelley was inspired by recent developments in the science of the times. In 1790, Luigi Galvani had observed by chance that the dissected body of a frog was wracked by intense muscle spasms when the nerves of its legs were touched with an electrostatically charged metal scalpel. Galvani sensed that this response had to have something to do with something inherent to biological organisms, a force he called animal electricity and which, according to the scientist, was transmitted from the brain to the rest of the organism in order to produce movement.

Today, we know that the animal electricity observed by Galvani is the result of the presence of a difference in electrical potential between the inside and outside of our cells, which is called membrane potential, and is the result of the selective passage of ions through the cell membrane. Galvani could have had no idea of the nature of the phenomenon he was observing the very notion of electricity, at the time, was still rather unclear, with electrical phenomena being explained by the existence of an electrical fluid flowing through conductive bodies but he understood that the bodys response to the electrical current must have been related to something inside the body itself.

Galvanis experiments also clarified another point: the complex behaviour of life was not simply a problem of energy. It was not enough to provide a dead body with energy in just any form, such as heat or mechanical energy, for it to come alive. In order to obtain responses similar to the behaviour of a living body, something more specific was needed: a message expressed in physio-chemical language that the tissues of the organism were able to understand. This specificity is an inescapable characteristic of living matter: Unlike the rigid and passive bodies imagined by classical physics, which merely transfer energy by bumping into one another, living organisms seem capable of doing something more transforming external stimuli into a complex response.

Giovanni Aldini, the nephew of Luigi Galvani, took the study of animal electricity, which he called galvanism, to its extremes, applying his uncles discovery to the bodies of human beings and exhibiting its miraculous effects in a series of public demonstrations. In his most famous demonstration, which took place in London in 1803, Aldini administered a series of electric shocks to the corpse of a man who had been executed; the man began to come alive, shaken by intense muscular contractions.

Aldinis aim was precisely to determine the physical origin of that vital force present in all living organisms, and to control it, to the point of crossing the frontier between life and death. The fame of Aldinis demonstration undoubtedly contributed to Mary Shelleys description of Victor Frankensteins awakening of the Creature, even though there is no trace of lightning or electric shock in her original story: the role played by electricity in the creation of the monster, so central to the subsequent film adaptations of the work, is actually quite marginal in the novel.

The legacy of galvanism in Mary Shelleys story is instead mainly linked to the fundamental idea that the miracle of life could become accessible to scientific investigation, and that life itself was not alien to the domain of technological action. In short, the truly frightening aspect of crossing the boundary between living and inert matter was not so much the prospect of animating a corpse as the fear of discovering that we ourselves are but animated corpses, governed by the same forces as inorganic matter, yet somehow alive.

Contrary to what might be expected, although the details of the procedure of creation are never entirely revealed to the reader, in Mary Shelleys imagination, Frankensteins creation of the monster is more like a process of chemical synthesis than the result of a series of intense electrical shocks. The young Victor Frankenstein, with no access to the most up-to-date theories of natural philosophy, begins his autodidactic scientific training following in the footsteps of Renaissance magicians and alchemists such as Paracelsus and Cornelius Agrippa.

Upon arriving at university, the young Frankenstein, disappointed by the rigours of a modern science that spurns his dreams of greatness, is driven by a fatal attraction to chemistry, the only scientific discipline that seems capable of fulfilling the miraculous promises of the ancient occult sciences. As his chemistry professor tells him:

The ancient teachers of this science [] promised impossibilities and performed nothing. The modern masters promise very little; they know that metals cannot be transmuted and that the elixir of life is a chimera but these philosophers, whose hands seem only made to dabble in dirt, and their eyes to pore over the microscope or crucible, have indeed performed miracles. They penetrate into the recesses of nature and show how she works in her hiding-places. They ascend into the heavens; they have discovered how the blood circulates, and the nature of the air we breathe. They have acquir
ed new and almost unlimited powers; they can command the thunders of heaven, mimic the earthquake, and even mock the invisible world with its own shadows.

These fatal words, which will lead the young Victor down the road to ruin, seem to suggest that chemistry, despite the apparent humility of its methods, is the only science capable of revealing the secrets of life and death to the devoted scientist. And indeed, throughout its history, chemistry has often found itself wandering the edgelands of life, trying to understand the characteristics that a chemical system must possess in order to be considered living.

As we have seen, the study of complexity reveals that there is no rigid boundary between living and non-living matter: the difference between these two states of matter does not lie in the specific nature of their components, but has to do with different ways in which the same chemical components may be related to one another. What is more, the construction of chemical and nanotechnological systems capable of self-organization shows that, between the almost completely passive behaviour of a stone (the chemical structure of which, however, still has a certain degree of complexity) and that of an intelligent animal such as a human, there is a very dense spectrum of different material structures, each capable of interacting in a specific way with the reality around it.

Life is first and foremost a problem of organisation, and since the dawn of its history, chemistry has always been concerned with understanding how material relates to itself, organising itself spontaneously into the incredible variety of natural and artificial structures that exist. Even had he lived to the present day, the young Victor Frankenstein would probably have found that the study of chemistry answered best to his ambitions; perhaps, however, his monster would not have been a giant two-and-a-half-metre-tall humanoid, but a microscopic organism a few tens of nanometres across, with a far more alien, if no less threatening, appearance.

Shortly after the publication of Frankenstein, one of the most famous experiments in the history of chemistry was conducted. Studying the synthesis of ammonium cyanate from cyanic acid and ammonia, Friedrich Whler observed the unexpected precipitation of a white crystalline substance that had a different appearance from the inorganic salt he had expected to obtain. Whler identified this substance as an organic compound known as urea, a molecule naturally present in animal urine; he also noted that the substance he was trying to prepare and the substance he had obtained had the same elementary composition, i.e. they were both made up of the same atoms, but arranged in a different pattern.

This phenomenon, known in chemistry as isomerism, highlights once again the essential importance of structure in determining the behaviour of a chemical substance: here too, what separates a mineral substance from a biological one is not the substance itself, but its organisation and structure. Today, Whlers experiment is remembered as one of the crucial moments in the development of contemporary chemistry, and is often seen as coinciding with the birth of modern organic chemistry as such: it was one of the first occasions upon which a chemical compound produced spontaneously by living organisms was artificially synthesised in a chemical laboratory from inorganic reactants.

Prior to Whlers synthesis, the adjective organic was used to connote only substances derived from plants or animals; it is thanks to his experiment that today, in chemistry, the word denotes a specific class of carbon-based chemical compounds, and is now devoid of any necessary association with living organisms.

From Whlers experiment onward, the ability of chemistry to produce substances that are hybrid, i.e. neither entirely inorganic nor entirely living, called into question the rigid separation between life and death but also, and perhaps more significantly, between life and technology. And this unexpected continuity expressed in the synthetic approach of chemistry also emerges in the way in which the development of the chemical sciences has influenced the language we use to talk about matter.

The customary terminology we have used to distinguish the living world from the non-living has always been problematic. Non-living materials have been defined as inorganic, inert, inanimate, or disorganised, but each of these terms has ultimately proved inadequate as a way to specify the precise boundaries where life begins: we have synthesised organic materials from inorganic substances and discovered materials that, although not alive, are capable of moving, growing and remembering.

Chemical matter, whether organic or inorganic, is active and dynamic, capable of forming complex organisations on different scales, evolving, and spontaneously modifying its structure in response to the environment. For this reason, rather than considering life as an extraordinary phenomenon, miraculous and extraneous to all other behaviours of matter, chemistry provides us with the tools to think of life as one of the many different types of dynamic organisation that matter can assume.

In light of these discoveries, it is still possible to provide a definition of life? How can we draw new boundaries for a category that is so elusive, yet so fundamental for us?

The synthesis of urea is undoubtedly a far more modest result than the one that an ambitious Victor Frankenstein envisioned: The experiment did not lead to the synthesis of an entire organism, it merely demonstrated that certain chemicals present in living organisms can be obtained from inorganic components. However, Whlers result can also be regarded as the first step in a long scientific journey that has brought chemistry closer and closer to an operational understanding of living matter.

In 1862, Louis Pasteur definitively demonstrated the impossibility of the spontaneous generation of living organisms from decaying matter, finally putting paid to a deep-rooted belief that had survived in the history of scientific thought since the time of Aristotle. A new principle was therefore emerging: life could only be produced from other life, it was not possible for it to emerge from non-living matter. Two opposing tendencies converged: on the one hand, organic chemistry was increasingly effective in demonstrating the ability of inorganic matter to transform, under the appropriate conditions, into the chemical ingredients of life; on the other hand, biology was now convinced that it was impossible to generate life under any circumstances except from an already-formed living being.

But then how was it possible for life to have emerged on Earth in the first place?

Pasteurs dogma, while useful in disproving an unfounded superstition about the spontaneous birth of certain organisms, raised a new barrier between inorganic matter and living matter that was destined to be gradually eroded by new scientific theories of the origin of life. The idea that life originated from non-biological chemical components is known as abiogenesis, and was advocated by the Russian biologist Aleksandr Ivanovi Oparin, who, in his 1924 book The Origin of Life, was the first to develop the theory of chemical evolution, i.e. the idea that life emerged from increasingly complex organic molecules.

According to Oparin, this approach makes it possible to overcome both the notion that life is a unique and unreproducible phenomenon and the ancient theory of spontaneous generation, rooted in vitalism and equally unviable as an explanation for the origin of life on Earth.

Following in the footsteps of Oparins theories, the American chemist Stanley Miller, under the guidance of his professor Harold Urey, developed a crucial experiment in 1953, designed with the aim of demonstrating that abiogenesis was indeed possible, and that the primordial Earth could have furnished appropriate conditions in which lifes constituent molecules could have been spontaneously produced from a set of inorgani
c ingredients.

Miller developed a simple experimental apparatus consisting of a flask of boiling water in contact with a special gas mixture consisting of ammonia, methane and hydrogen, which, according to the theories of Oparin and Urey, approximated the primordial atmosphere present on Earth at the time when life first emerged. Electrical discharges similar to lightning strikes were then produced within the system by means of two metal electrodes. After a week, Miller purified the aqueous solution he obtained and subjected it to a crude chemical analysis and confirmed, to his own surprise, that it contained several amino acids, the basic chemical ingredients of living organisms.

Beyond the incredible scientific value of his discovery, there is something romantic in Millers experiment an echo of the 19th-century myth of dead matter animated, in the primordial night of the world, by the power of thunder and lightning.

Laura Tripaldi is a PhD student in materials science and nanotechnology at Universit degli Studi di Milano-Bicocca. She is the author of Parallel Minds, from which this article was first excerpted for the MIT Press Reader, and republished here with permission.

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The Occult Origins of Chemistry and the Stuff of Life The Wire Science - The Wire Science

Babar credits history and chemistry after record-breaking stand with Rizwan – Hindustan Times

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After a forgettable Asia Cup, followed by a 24-ball 31 against England in the series opener, Babar Azam's rough patch finally took a halt on Thursday evening in Karachi. The Pakistan skipper, who had just managed 98 runs in previous seven T20I matches, slammed an unbeaten 110 off 66 balls and led his team to a handsome 10 wickets victory in the second T20I.

Babar's knock was equally supported by his opening partner and in-form batter Mohammad Rizwan, who scored 88 off 51 deliveries, helping Pakistan chase a stiff 200-run target with three balls to spare. The feat saw the duo stitch a record-breaking double-century opening stand, surpassing the previous best, which was also set by the same pair. Babar and Rizwan held the previous record of Pakistan's 197-run opening-wicket stand, which they made against South Africa at Centurion in 2021.

Also Read: Shaheen Afridi's 'time to get rid of selfish Kaptaan Babar, Rizwan' sarcastic tweet sends social media in frenzy

Apart from the two instance, Babar and Rizwan had also stitched an unbeaten 152-run partnership, demolishing India by 10 wickets in the previous edition of the T20 World Cup.

When asked to reflect on the partnership he built with Rizwan on the evening and in the past, Babar credited the history and chemistry between the two, which make things easier for them. He also mentioned about the trust level, which is such that there are incidents when they have sneaked runs between the wickets without having to call for it.

Humari communication kafi acchi hain, humne aise chase pehe bhi kiye hain, toh hamari chemistry kaafi milti hain. Kabhi kabhar hum aise runs lete hain ki hum call bhi nahi kartey, hum bhag jate hain. Yeh trust level hain, yeh trust level pure team mein hain. (Our communication is brilliant, even chemistry and we have chased high scoring targets previously. Sometimes we steal runs without a call, this is trust level we share.)

Hum koshish karte hain ek dusre pe trust kiya jaye as a team. (As a team we trust our teammates equally), the Pakistan captain said in the post-match press conference on Thursday.

With the win, Pakistan have bounced back in the seven-match series, which now stands tied at 1-1. England had won the opening encounter by six wickets.

At HT Sports Desk, passionate reporters work round the clock to provide detailed updates from the world of sports. Expect nuanced match reports, previews,reviews, technical analysis based on statistics, the latest social media trends, expert opinions on cricket, football, tennis, badminton, hockey,motorsports, wrestling, boxing, shooting, athletics and much more....view detail

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Jimmy Garoppolo getting quick chemistry lesson with 49ers new receivers – The Athletic

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SANTA CLARA, Calif. Ray-Ray McCloud III said he had instant chemistry with Jimmy Garoppolo when they first talked shop in the 49ers locker room this summer. The challenge now is to jell just as well on the field.

Its all about being on the same page, McCloud said 20 minutes before the 49ers took the field for Garoppolos first practice as the starter this season.

He missed all of the spring practices and training camp and was the scout-team quarterback the first two weeks of the season. That meant a few passes to rookie Danny Gray ahead of the Week 1 game against the Bears but no real throwing sessions with him, McCloud or any of the newcomers to the offense this year.

That didnt seem to be an issue with McCloud on Sunday. Garoppolos first pass to him was a 16-yard completion in the second quarter that preceded a touchdown throw to a more familiar target, Ross Dwelley.

With rain in the forecast, McCloud said the pregame coaching point for the quarterbacks was to put the ball on the receivers bodies. When the skies opened up, McCloud said, thats exactly what Garoppolo did.

He said the 49ers quarterback reminded him a lot of former

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Jimmy Garoppolo getting quick chemistry lesson with 49ers new receivers - The Athletic

Amber Heard`s bad chemistry with Jason Momoa led to reduced role in `Aquaman 2`, claims her agent – WION

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Hollywood actor Amber Heard`s agent has claimed that the "lack of chemistry" between her and Jason Mamoa was why her role got reduced in 'Aquaman and the Lost Kingdom'.

According to Fox News, Heard`s agent, Jessica Kovacevic, virtually testified in Johnny Depp`s defamation trial on Friday stating the negative light on Heard, due to the ongoing conflicts with Depp, greatly impacted her role.

She testified that the star was contracted to make USD 2 million in the 'Aquaman'sequel, which has already concluded filming and is set to hit theatres in March 2023. The agent further claimed that Warner Bros axed Heard`s role because there was a "lack of chemistry between her and Jason."

She went on to say that Heard received the news of the reduced role as she was reading the script. On being inquired regarding Heard`s harmed career, her agent responded, "In my experience ... Your career takes a turn after something like that. As per Fox News, Kovacevic added that the actor even lost a role with Amazon that was in the works due to the bad press and claimed that, to her knowledge, there were no "performance issues raised" against Heard in the first `Aquaman` movie.

Also Read:Johnny Depp's was financially broke and had anger issues, actor's former agent reveals

Amber Heard was the first cast in 2017`s `Justice League` film and then made her debut in the 'Aquaman'franchise as Mera the following year.

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Amber Heard`s bad chemistry with Jason Momoa led to reduced role in `Aquaman 2`, claims her agent - WION

4-Hydroxypyrimidine Market- increasing demand with Industry Professionals: Alfa Chemistry, BeiJing Hwrk Chemicals, Shanghai Longsheng chemical, Jinan…

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4-hydroxypyrimidine-market

Glob Market Reports offers an overarching research and analysis-based study on, Global 4-Hydroxypyrimidine Market Report, History and Forecast 2016-2028, Breakdown Data by Companies, Key Regions, Types and Application. This report offers an insightful take on the drivers and restraints present in the market. 4-Hydroxypyrimidine data reports also provide a 5 year pre-historic and forecast for the sector and include data on socio-economic data of global. Key stakeholders can consider statistics, tables & figures mentioned in this report for strategic planning which lead to success of the organization. It sheds light on strategic production, revenue, and consumption trends for players to improve sales and growth in the global 4-Hydroxypyrimidine Market.

Some of the key manufacturers operating in this market include: Alfa Chemistry, BeiJing Hwrk Chemicals, Shanghai Longsheng chemical, Jinan Trio PharmaTech, Chengdu JingXin Technology and More

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Here, it focuses on the recent developments, sales, market value, production, gross margin, and other significant factors of the business of the major players operating in the global 4-Hydroxypyrimidine Market. Players can use the accurate market facts and figures and statistical studies provided in the report to understand the current and future growth of the global 4-Hydroxypyrimidine market.

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4-Hydroxypyrimidine market competitive landscape offers data information and details by companies. Its provides a complete analysis and precise statistics on revenue by the major players participants for the period 2022-2028. The report also illustrates minute details in the 4-Hydroxypyrimidine market governing micro and macroeconomic factors that seem to have a dominant and long-term impact, directing the course of popular trends in the global 4-Hydroxypyrimidine market.

Market split by Type, can be divided into: Purity 98% Purity 99% OthersMarket split by Application, can be divided into: Chemical Pharmaceutical

Regions Covered in the Global 4-Hydroxypyrimidine Market:1. South America 4-Hydroxypyrimidine Market Covers Colombia, Brazil, and Argentina.2. North America 4-Hydroxypyrimidine Market Covers Canada, United States, and Mexico.3. Europe 4-Hydroxypyrimidine Market Covers UK, France, Italy, Germany, and Russia.4. The Middle East and Africa 4-Hydroxypyrimidine Market Covers UAE, Saudi Arabia, Egypt, Nigeria, and South Africa.5. Asia Pacific 4-Hydroxypyrimidine Market Covers Korea, Japan, China, Southeast Asia, and India.Years Considered to Estimate the Market Size:History Year: 2015-2022Base Year: 2022Estimated Year: 2022Forecast Year: 2022-2028

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Key highlights of the 4-Hydroxypyrimidine Market report: Growth rate Renumeration prediction Consumption graph Market concentration ratio Secondary industry competitors Competitive structure Major restraints Market drivers Regional bifurcation Competitive hierarchy Current market tendencies Market concentration analysisCustomization of the Report: Glob Market Reports provides customization of reports as per your need. This report can be personalized to meet your requirements. Get in touch with our sales team, who will guarantee you to get a report that suits your necessities.

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4-Hydroxypyrimidine Market- increasing demand with Industry Professionals: Alfa Chemistry, BeiJing Hwrk Chemicals, Shanghai Longsheng chemical, Jinan...

Thermal Interface Materials Market by Chemistry, Type, Application and Region – Global Forecast to 2027 – Yahoo Finance

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Growth in the thermal interface materials market can primarily be attributed to the growing involvement of amorphous polyethylene terephthalate in the computers, telecom, medical devices, among others.

New York, May 19, 2022 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Thermal Interface Materials Market by Chemistry, Type, Application and Region - Global Forecast to 2027" - https://www.reportlinker.com/p04057026/?utm_source=GNW Thermal interface materials (TIMs) are used to remove the heat generated by semiconductors to maintain the junction temperature of electronic & electrical components within safe operating limits.

This heat removal process involves the conduction from a package surface to a heat spreader that can transfer the heat to the ambient environment more efficiently. The global thermal interface materials market size is estimated at USD 3.4 billion in 2022 and is projected to reach USD 5.6 billion by 2027, at a CAGR of 10.5%. Growth in the thermal interface materials market can primarily be attributed to the increasing use of TIMs in end-use industries and the growing electronics industry.The production of TIMs is driven by its large-scale industrial applications, such as computers, telecom, medical devices, industrial machinery, consumer durables, and automotive electronics.The growing consumer electronics industry is a major driver.

The demand for TIMs in developed countries, such as the US, the UK, Germany, and Canada, is high, owing to numerous development strategies adopted by manufacturing companies.The demand for TIMs in Asia Pacific is expected to increase at the highest rate, mainly due to the transportation sector, as China represents the largest automotive market globally.

The growing automotive industry is expected to drive the TIMs market in the region.The major challenge for manufacturers of TIMs is the stringent government regulation on the reduction of VOC content.

The untapped markets of the Middle East are a major opportunity for the growth of the players in the market. Increasing development strategies are also an excellent growth opportunity for manufacturers to have better control over the cost and quality of products.

Silicone is the largest and fastest-growing chemistry segment of the thermal interface materials market.

The thermal interface materials market is segmented on the basis of chemistry into silicone, epoxy, polyimide, and others.Silicone is largest and is expected to witness the fastest growth rate.

Silicone exhibits good resistance to a wide range of temperatures, from -55C to +300C, resistance to chemical attack, resistance to shock & vibration, stability under mechanical stress, stability against weathering, and greater hydrostability.It is also handled without any special precautionary measures and offers easy processing without the need for oven drying or concerns about exothermic heat during the processing.

Silicone is used in various TIMs such as greases & adhesives, encapsulants & potting compounds, thermal pads, and gap fillers.

Greases & adhesives is the largest type segment of the thermal interface materials market.

The thermal interface materials market is segmented on the basis of type into greases & adhesives, tapes & films, gap fillers, metal-based TIMs, phase change materials, and others.Greases & adhesives is largest type.

Thermal greases & adhesives are applied to one of the two mating surfaces; when the surfaces are pressed together, the grease spreads to fill the void.Thermal greases & adhesives are normally packaged in a syringe, tube, or a small plastic sachet.

OEMs prefer to use greases & adhesives because of their ability to flow into any nook of the intended application and conform to a wide range of surface roughness present on the housing, heat spreader, or heat sink surface.Thermal greases & adhesives have other competitive advantages such as cost, rework-ability, low thermal resistance, and the ability to form ultra-thin bond lines.

The manufacturing costs of greases & adhesives are lower as these materials do not need to be coated and cured into a sheet and cut to shape.

Computers is the largest application of thermal interface materials market.

The thermal interface materials market is segmented on the basis of applications into computers, telecom, consumer durables, medical devices, industrial machinery, automotive electronics, and others.Among these, the computer segment is the largest application.

Computer components, such as CPUs, chipsets, graphics cards, and hard disk drives, are susceptible to failure in case of overheating.TIMs are used in computers to remove the excess heat to maintain the components operating temperature limits.

TIMs are used in computers to optimize the performance and reliability for smooth functioning.TIMs are used for improving the heat flow in computers by filling voids or irregularities between the heat sink and SSE base plate mounting surfaces.

TIMs have comparatively greater thermal conductivity than the air they replace, thus allowing efficient heat transfer resulting in the improved performance of computers. The use of TIMs in computers is growing at a high rate because of the increased demand for cloud and supercomputing. The increased demand for supercomputing is driving the market for high-performance silicon and TIMs.

APAC is the fastest-growing market for thermal interface materials.

APAC is the largest market for thermal interface materials market due to increased investments by developing countries of the region, such as Indonesia and India, are supporting market growth in the region. Another major driving factor is the increased demand for the miniaturization of electronic devices.

The breakdown of primary interviews is given below: By Company Type: Tier 1 15%, Tier 2 25%, and Tier 3 60% By Designation: C-Level Executives 12%, Director-Level 20%, and Others 68% By Region: North America 40%, Europe 30%, APAC 20%, and South America 10%The key companies profiled in this report on the thermal interface materials market include Honeywell International Inc. (US), 3M (US), Henkel AG & Co. KGaA (Germany), Parker Hannifin Corporation (US), Dow Corning Corporation (US), Laird Technologies (US), Momentive Performance Materials (US), Indim Corporation (US), Wakefield-Vette (US), and Zalma Tech Co. Ltd. (South Korea) are the key players operating in the thermal interface materials market.

Research CoverageThe thermal interface materials market has been segmented based on chemistry, type, application, and region.This report covers the thermal interface materials market and forecasts its market size until 2027.

It also provides detailed information on company profiles and competitive strategies adopted by the key players to strengthen their position in the thermal interface materials market.The report also provides insights into the drivers and restraints in the thermal interface materials market along with opportunities and challenges.

The report also includes profiles of top manufacturers in the thermal interface materials market.

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Thermal Interface Materials Market by Chemistry, Type, Application and Region - Global Forecast to 2027 - Yahoo Finance

This Space Rocks Weird Chemistry Suggests It Came From a Supernova – Gizmodo

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In 1996, a rock from space was found in southwestern Egypts Great Sand Sea. The rock was odd, even by extraterrestrial standards, and a team of researchers studying the rocks chemistry now propose that it came from a supernovathe brilliant, explosive collapse of a star.

The rock is named Hypatia, after a 4th-century Egyptian mathematician. Based on the pattern of 15 elements in a 3-gram sample of the stone, a team of researchers suspects Hypatia came from well beyond our stellar neighborhood, and emerged from the gas and dusty detritus that followed a distant stars explosion. Their research is published in the journal Icarus.

The researchers think Hypatia came from a Type Ia supernova; these supernovae occur when white dwarves (the small, dense remnants of stars) consume so much material, often from a neighboring star, that they explode. That distinguishes Typa Ia from Type II supernovae, in which a large stars core collapses, causing a massive explosion.

In a sense we could say, we have caught a supernova Ia explosion in the act, because the gas atoms from the explosion were caught in the surrounding dust cloud, which eventually formed Hypatias parent body, said Jan Kramers, a geochemist at the University of Johannesburg, in a university release.

According to the release, the intermingling of gas atoms from the supernova and the dust in which the explosion occurred probably formed a solid rock around the early stages of our own solar system, billions of years ago. On entering and impacting Earth, the parent rock of Hypatia shattered, creating the fragment found in 1996.

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Kramers has been studying Hypatia for nearly a decade. In 2013, argon isotopes from the rock confirmed Hypatias extraterrestrial origins, and follow-up studies in 2015 and 2018 indicated that Hypatia was neither from any known comet or meteorite nor from our solar system. Using a proton microprobe, the team inspected the elemental makeup of Hypatia. They found that the elements from the rock indicated it didnt even come from interstellar dust in our arm of the Milky Way.

Hypatia had too much iron to come from a Type II supernova or a red giant star. Thus, the researchers surmised that the most likely explanation for Hypatias unique combination of silicon, sulfur, calcium, titanium, vanadium, chromium, manganese, iron, and nickel was a Type Ia supernova.

Six elements were a lot more present than what models predict for something that came from a Type Ia supernova, though: aluminum, phosphorus, chlorine, potassium, zinc, and copper. Kramers believes Hypatia may have inherited those elemental components from the red giant star that preceded the white dwarf that eventually exploded.

The new research was merely exploratory, and further isotope analysis of the elements in Hypatia will need to happen in order to test the researchers hypothesis about the rocks origins.

More: A Vanished Supernova Will Reappear in 16 Years

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This Space Rocks Weird Chemistry Suggests It Came From a Supernova - Gizmodo

Unjustified industry pushback on EPAs toxic chemical regulation – The Hill

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Recently, the American Chemistry Council (ACC) undercut itsannouncement of supportfor President Bidens request to double fiscal year 2023 funding for the control of toxic substances, under the 2016 Toxic Substances Control Act (TSCA), with a strings attached demand that the Environmental Protection Agency (EPA) roll back six recent policy improvements that better protect peoples health. This was accompanied by claims that EPA is implementing policy changes that are out of touch with regulatory and economic reality.

As former senior EPA scientists and managers, we applaud ACCs support of a desperately needed increase in EPAs resources, but we are dismayed by the industrys push to reverse or modify policies that are essential to the success of the bipartisan 2016 TSCA amendments, which ironically industry supported.

The lack of EPA resources is jeopardizing the laws basic goal of accelerated risk reduction for substances posing known health and environmental threats. Instead of recognizingthe need for more timely and effective protection against unsafe chemicals, ACC warns of harms to innovation and growth. While these are unfounded fears, instead industry recommends reinstating Trump-era EPA toxics policies that undermine the 2016 law and weaken health protections.

First, it appears the industry wants EPA to ignore peoples exposure to chemicals from air emissions, water discharges, drinking water and waste disposal when evaluating the risks of existing chemicals. Failure to address these exposure pathways will result in incomplete risk evaluations and weak risk management. EPA is appropriately redoing several of the first 10 risk evaluations conducted under the amended law to account for environmental exposure in fenceline communities. This is a major step in strengthening protections for at-risk populations.

ACC next opposes making determinations of unreasonable risk that evaluate the chemical as a whole, and insists that EPA make separate risk determinations for each of the chemicals uses. Under the whole chemical approach, EPA can consider whether and how a single use that does not pose an unreasonable risk in isolation may contribute to total risk in combination with other uses. This assures that the total risk to subpopulations exposed on the job, at home and in the environment is taken into account. In our view, ACC is wrong in predicting that this approach will lock EPA into unfairly branding all uses of a chemical as unsafe. EPA can regulate uses posing unreasonable risk while identifying uses that can continue without restrictions.

ACC thirdly argues that, in evaluating risks to workers, EPA must assume they are wearing Personal Protective Equipment (PPE). However, as EPAs science advisers emphasized, this approach does not reflect reality. There are no PPE requirements for most chemicals. Even when required, small and medium sized enterprises often do not adopt or enforce PPE controls, and PPE such as respirators may be ill-fitting or used intermittently by workers. During the TSCA risk management process, EPA can make accommodations for situations in which health-protective, fully functional PPE will be employed throughout the workday.

Next, ACC claims that the Biden administration is failing to use the best available science and weight of evidence in risk evaluations. This is a stunning charge given the widely reported breaches of scientific integrity that occurred during the Trump administration. The science EPA now uses for TSCA risk evaluations follows recognized guidelines and is rigorously peer reviewed.

ACC also asserts EPA must meet deadlines (90-days) to review new chemicals. The answer to addressingdelays is to provide EPA with adequate resources to make safety determinations in an informed and science-based manner, not cut corners on safety reviews for the benefit of industry.

Finally, industry complains EPA is increasing fees charged to chemical manufacturers for risk evaluations without any accountability or improvements in service. In passing the bipartisan 2016 amendments to TSCA, Congress expected EPA to collect up to 25 percent of TSCA costs from fees. The Trump-era EPA excluded the first 10 risk evaluations from any fees, and industry fee payments have been well below the statutory target. Clearly, manufacturers have not been unduly burdened by fees and would not suffer if required to pay more.

The chemical industry, every member of Congress and the American people should support the president 2023 budget request for a functioning and effective toxic substances control program. Every one of us and especially people living and working in frontline communities is exposed to toxic chemicals daily, most of which are unregulated in the United States. Our health and welfare depend on their control. We must not let the chemical industry take us backward.

Elizabeth Southerland, Ph.D., is the former director of science and technology, EPA Office of Water.

Robert Sussman is former EPA senior policy counsel.

Linda Birnbaum is the former director of the National Institute for Environmental Health Sciences.

Penny Pfenner-Crisp is a former senior science adviser for EPAs Office of Pesticide Programs.

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Unjustified industry pushback on EPAs toxic chemical regulation - The Hill

Living through the war in Ukraine | Opinion – Chemistry World

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I just read they bombed Kyiv. This is the worst! Im so sorry. A message from my labmate was the first I saw about the full-scale Russian invasion. I called my parents in Dnipro. Several strategic objects in the city had been hit, but they are adamant about staying. We stocked up on water and arent going anywhere. Dont worry about us. They dont want to flee again.

Back in 2014, when I was studying in France, they got stuck in Donbas taking care of my grandma. On the phone with my mom in the evenings she would tell me about armed people, clearly not locals, marching on our street, military vehicles entering the town, someone organising fake referendums. Sometimes over the phone, I could hear the shelling. They managed to escape to Dnipro with my grandma. None of us have since been able to return to Donbas. Apart from the logistics, its just not safe there if you have an openly pro-Ukrainian position.

Still, we are luckier than many in Ukraine. Dnipro is a relatively safe city, thanks to its geographic position and the efforts of the Ukrainian army. And I am abroad with a job and a lab. Many Ukrainian scientists have had their research disrupted and put on hold indefinitely. Many have also joined the Ukrainian army or volunteer. And some, such as inorganic chemist Oleksandr Korsun, a lecturer at Kharkiv National University, have been killed in Russian shelling.

This war affects the lives of Ukrainians everywhere. Im not in the country, and Im still entirely consumed by what is happening there. These days I often need an extra effort to focus on my research. My supervisor Pete Skabara is supportive and he is also very involved, helping to set up the humanitarian aid point at the University of Glasgow and getting in touch with the Royal Society of Chemistry regarding ways to support chemists in Ukraine. And I assist by collecting information on Ukrainian scientists needs. I also work as a translator for the volunteer news organisation WithUkraine, and constantly look for ways to make the voices of Ukrainians, including chemists, heard internationally.

In my quest to interview Ukrainian chemists, I tried to reach out to Anton Senenko, a researcher at the NASU Institute of Physics in Kyiv. Since the end of February, hes been helping with the evacuations in the most hellish regions of Ukraines north. He saw Bucha and Irpin after Russian troops left. His Facebook feed is full of photos of burnt windowless buildings and civilian cars. I have not heard from him yet. I dont think hes doing much science these days.

Almost all the Ukrainian chemists I have spoken to say the same thing. They need academic support in various forms, and appreciate all of it, but the most critical thing Ukrainian chemists need right now is our countrys victory. Without it, no proper work can happen. The only chance for Ukrainian chemists to reach their full potential wherever they currently are is to know that their country is safe.

Things are deteriorating just over the course of my writing this piece. Every day that the Russian invasion continues costs Ukraine its infrastructure and, more importantly, our people. The situation in the chemical industry was already dreary before the invasion; many Ukrainian chemists had already left the profession for more lucrative jobs in different areas. Now there is a risk it could be entirely obliterated. I hope that soon we will be able to rebuild but also make it better than it was. It will not be easy and will require transformations on multiple levels, including profound institutional changes. Still, I am sure there are enough people keen to help with those, including the Ukrainians who got their education and professional experience outside of the country.

I am incredibly grateful for the assistance given so far, and I hope that this spirit of international support and collaboration continues until Russia withdraws all its troops from our land, and also in peacetime afterwards.

These days Im the most homesick I ever was in my over 10 years of living abroad. However, among the horrific pictures of the pain and destruction Russia brought to our land, I notice signs of hope. Under each photo of a destroyed infrastructure object or house, you will find several comments saying that we will rebuild as long as we are alive. Given the opportunity, I would happily return to Ukraine, to help with whatever I can. Im sure Im not the only one feeling this way.

But first, we need victory.

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In partnership with the WHO, FAO, UNEP and WIPO the Royal Society of Chemsitry is proud to immediately grant Research4Life access to our journals content to the Ukrainian scientific community. Registration is free and allows both on- and off-campus access.

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Penn State chemistry instructor named 4-H Northeast Volunteer of the Year – Pennsylvania State University

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UNIVERSITY PARK, Pa. Susan Swope, an adjunct chemistry instructor at Penn State DuBois and a Penn State alumna, was named 4-H Northeast Volunteer of the Year in the annual 4-H Salute to Excellence Awards announced recently by the National 4-H Council.

The award includes a plaque and a $200 donation in Swopes name to the 4-H organization of her choice: the 4-H program administered by the Clearfield County office of Penn State Extension.

Empowering youth is second nature to Susan, said her nominator, Hannah Alexander, a 4-H youth development extension educator based in Clearfield County.

As a Clearfield County volunteer since 2015, Swope has served as both a club organizational leader and as a member of the countys 4-H program development committee. In this role, Swope seeks to promote the program, express the needs of volunteers and engage new youth. Over the last two years, her efforts within the committee have ushered more than 20 new families and four volunteers into the county program.

Leading a club with more than 40 members, Swope fosters a welcoming environment for youth and families alike. She encourages her members to learn and work together and values their input when planning activities. Swope incorporates hands-on activities to challenge and teach youth about livestock skillathons, feed ingredients, butter making, thank-you notes, meat cuts, biosecurity practices and other topics.

A top priority for Swope is encouraging youth to become good citizens who seek to Make the Best Better in collaboration with fellow 4-Hers. Other goals include promoting social skills, record-keeping skills and outreach to the public about agriculture.

Alexander noted that Swope continually aims to develop her own skills as a leader through 4-H leadership training and professional development opportunities.

I have witnessed Susan improve and expand the quality of learning through different programs within and outside the club environment, Alexander said. She strives to provide youth with intentional learning experiences that transfer to real-world skills.

Swope surpasses expectations of a club leader by devoting additional time to complete surveys, assess curriculum or programs, and offer meaningful impact statements for the county and state.

She is a trusted and valuable resource that other volunteers and I go to for constructive feedback and guidance, Alexander added.

Before her position as a 4-H volunteer, Swope participated in 4-H as a youth member in Tioga County for 10 years. She held numerous leadership and officer positions during her time as a member.

Swope earned a masters degree in chemistry from Penn State. She currently teaches the organic chemistry series and second-semester general chemistry at Penn State DuBois.

Administered in Pennsylvania by Penn State Extension, 4-H is a community of more than 6 million young people across America learning leadership, citizenship and life skills. Penn State Extension 4-H youth development educators in all 67 counties administer local 4-H programs through nonformal education and outreach. More information about Pennsylvania 4-H and local county programs is available on the Penn State Extension website.

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Penn State chemistry instructor named 4-H Northeast Volunteer of the Year - Pennsylvania State University

The return of My Chemical Romance – The Depaulia

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Last week, My Chemical Romance surprised fans by quietly releasing Foundations of Decay, their first high-profile release since their 2014 Fake Your Death release.

During the eight years between the bands 2013 breakup and 2019 reconciliation, many fans were surprised to see My Chemical Romance officially back in action.

Despite the bands tightlipped behavior regarding releasing new music, Foundations of Decay, embodies the taboo qualities that made the genre of emo famous guaranteeing to connect with both longtime and new listeners.

Within the six-minute single, lead singer Gerard Ways gritty vocals and nostalgic blend of emo chords and percussion are highlighted, acting as a welcome return to the familiar sound that defined the early 2000s.

Longtime My Chemical Romance fan and DePaul sophomore Nicholas Magel expressed his excitement for the bands comeback.

MCR was a band that I grew up with and probably the first band I would have called myself a huge fan of. They will always have a place in my heart. There will always be a part of me cheering them on, Magel said.

Since the bands establishment in 2001, they have released over four studio albums and over 90 songs, covers and demos.

As for My Chemical Romances latest release, Magel praises the bands decision to keep their iconic sound and jagged themes of aging and the unstoppable passage of time.

I think it reminds me a lot of the older stuff they put out. Not to deconstruct the music or anything, but I feel like it goes well with the sound they had made, Magel said. It kind of made me feel like I was living in my childhood again, running around my house with earbuds in singing along.

DePaul junior Kaitlyn Milligan articulated a desire for the band to maintain the angst-ridden ambiance that so many fans have grown to love.

I hope that they keep their emo atmosphere as that is how they grew their fan base and thats why so many of us love MCR because they are so emo. Plus, by keeping their old brand it will feel more nostalgic which I like with music, Milligan said.

Although Foundation of Decay is the bands first launch in almost a decade, it has been anything but a disappointment. Reeling in over 6 million streams in under a week, the singles success proves My Chemical Romances fans remain just as loyal as they were in 2013.

While I think that Foundations of Decay is not their best song, it is not an awful song either, Milligan said. I felt that the beginning of the song sounded like any other generic alt rock song, but the later part of the song sounded like older MCR which I appreciated a lot as it took me back to listening to their older albums. I just really like how the last part was edgier and rawer.

DePaul freshman Kyle Duke explained what elements of the song stood out to him the most.

It has that classic My Chemical Romance sound, with loud, emotional guitar chords layered with Gerards almost whiny vocals, Duke said. It feels like emo pop-punk squished with parts of contemporary hard rock.

Before their split, My Chemical Romance managed to encapsulate a different modulation in each of their four albums, from the cemented emo, post hard-core sound of their first major release, I Brought You My Bullets, You Brought Me Your Love, to the gothic cathedral harmony of Three Cheers for Sweet Revenge.

The chorus is catchy as hell like always and the outro is brutal, said Duke.

While it is difficult to predict when My Chemical Romance will release more music, its more than evident that they will always have the fan base to rely on, no matter how many years pass.

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Biochemist Marie Maynard Daly uncovered what makes us tick – Popular Science

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The annals of science journalism werent always as inclusive as they could have been. SoPopSciis working to correct the record withIn Hindsight, a series profiling some of the figures whose contributions we missed. Read their stories and explore the rest of our 150th anniversary coveragehere.

Crack open any high school science textbook, and itll likely contain a few basic concepts of human biology: amylase, the enzyme that chews up starch and spits out sugar; histones, the tiny protein spools around which DNA winds; cholesterols frightening knack for narrowing arteries; and the relationship between DNA, RNA, and protein that constitutes the central dogma of molecular biology. What you likely wont find is a reference to the American biochemist Marie Maynard Daly, who contributed fundamental research to all of these ideas throughout her prolific career.

The omission is neither a surprise nor an accident. Daly, a Black woman, was underappreciated for much of her professional life, which spanned from the 1940s to 1986. When she is remembered now, it is most often as the first African American woman to earn a Ph.D. in chemistrya remarkable accomplishment in the late 40s, but just one of many scientific and social achievements of her lifetime. The most important thing to me was the fact that she opened the gates for people who would not really join this field, says retired chemistry professor Paris Svoronos, who is involved in the American Chemical Societys effort to honor Daly with a National Historic Chemical Landmark plaque at Columbia University.

Born in 1921 in Queens, a borough of New York City, Daly was driven from an early age to pursue excellence in spite of barriers. She took it upon herself to basically change the conditions, says Svoronos of her eventual path into chemistry. Her father had dropped out of a chemistry program at Cornell because he couldnt afford room and board.

Excelling in the sciences at local public schools, Daly was accepted at Queens College, a city-funded institution that students with good grades could attend for free. After receiving her bachelors in chemistry in 1942, she continued working there as a laboratory assistant and tutor to build up savings. Fellowships for a masters degree at New York University and doctoral studies at Columbia University followed. Her supervisor, Mary L. Caldwell, took Daly on at a time when there were few African American students in chemistry, notes chemist Jeannette Brown in her book African American Women Chemists. In 1947, with a dissertation on the impact of pancreatic amylase on corn starch, Daly earned her Ph.D.

Finding a job cant have been easy. For minority women scientists, it did not matter whether one is being hit with the club of sexism or racismthey both hurt, a 1976 American Association for the Advancement of Science report noted. Yet the same year Daly earned her doctorate, she was hired to teach physical science at Howard University. Soon after, she received a grant to fund research at The Rockefeller Institute. There, with the molecular biology pioneer A.E. Mirsky, she studied the components of the cell nucleus. These included the aforementioned histones; the As, Ts, Gs, and Cs that make up DNA; and ribosomes, the cellular factories that convert information encoded in RNA into proteins. When James Watson won his Nobel Prize with Francis Crick in 1962 for determining the structure of DNA, he referenced a ribosome study Daly co-authored in his accompanying lecture.

When she began teaching biochemistry at Columbia University and, later, became an assistant professor at the Albert Einstein College of Medicine in the Bronx, she shifted her research focus to the heart, helping establish what is now common knowledge: consuming too much cholesterol is linked to narrowing blood vessels and high blood pressure. She continued teaching and researching at Einstein until she retired, as associate professor, in 1986.

Most of what we know about her life could have been found in her CV. Few interviews or profiles of her exist. By the time her extraordinary contributions finally began to receive recognition, it was too late to learn more; Daly died in 2003. While we can read her papers and recite a few basic facts, theres a whole wealth of her life missing, wrote journalist Megan Scudellari.

The legacy Daly left behind, however, has had an impact on younger generations of Black scientists. Her mentee at Einstein, the late Francine Essien, became a professor of biology at Rutgers and champion of racial diversity in STEM fields. Chemist Sibrina Collins, executive director of The Marburg STEM Center at Lawrence Technological University and author of African American Chemists, calls Daly an inspiration. In 1988, Daly herself started a scholarship fund, named after her parents, to support Black students in the physical sciences at her alma mater, Queens College.

During his own tenure at Queensborough Community College, chemist Svoronos never failed to share Dalys story. Most students at the college, which sits in the public school system where Daly began her education, are Black or people of color; many are immigrants. Daly, thanks in part to his efforts, will be honored with an American Chemical Society plaque at Columbia University in May 2023. This is the type of role model they should have in their life, he says. Shes a model for every single person who may start from nothing.

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Biochemist Marie Maynard Daly uncovered what makes us tick - Popular Science

Cancer progression and harmful bacteria tracked with next-generation sequencing – Chemistry World

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Next-generation sequencing can be used to continually assess and monitor risks in patients with leukaemia, a new proof-of-principle study has shown.

The new application for the technique is part of a revolution in cancer treatment that has come about as a result of the precipitous drop in the cost of sequencing. This method could become even more widely used in tracking progression of cancers and other diseases in the future, paving the way for more targeted, personalised and non-invasive treatments.

The study used next-generation sequencing to assess the presence of mutations thought to commonly exist in leukaemia patients and to identify harmful microorganisms. The team collected 156 blood and bone marrow samples from 20 children going through induction chemotherapy for six weeks, during which the body is immunosuppressed and therefore prone to infection. The team also captured DNA of interest and sequenced it, shifting the focus to only clinically relevant DNA instead of carrying out whole genome sequencing.

Tracking leukaemia-related mutations allows clinicians to monitor how the disease is spreading in the patient. If we see a persistence of those mutations throughout treatment, we know theres still some leukaemia there, says study co-author Charles Gawad, a pediatric oncologist at Stanford University in California.

Some microorganisms multiply during induction therapy while the patient is immunosuppressed, while others either decrease or remain constant, Gawad says.Strikingly, the study found that viruses from the herpes and polyoma families were reactivated during induction therapy. Those are the kind of things we dont typically monitor, Gawad notes. We really dont know what role theyre playing in the clinical course of the patients.

Gawad says that you dont normally find these viruses in healthy individuals but immunosuppression may mean they are not kept in check and can flourish. The question is, which of those microbes are important and which may be causing fevers? he asks. Could they be altering chemotherapy effectiveness? Could they be making us change our treatment for some reason?

With current technology, however, the whole process to sequence the genes in question can still take three to four days, Gawad says. For an acute illness, thats not fast enough.

Keith Robison, a computational biologist at the synthetic biology firm Ginkgo Bioworks, notes that the study only considered DNA viruses, not RNA ones. But Robison says targeting rare cancer-related mutations and specific pathogens when treating cancer patients is the future. It has the opportunity to give very rich datasets.

Robison says that the study sample of 20 patients is modest and much bigger randomised control trials would be needed to demonstrate real clinical benefit. But he notes that a study of this kind would have been unheard of a decade ago. It would just have been astronomically expensive.

With current practices, many leukaemia patients end up with fevers and its not clear why, Gawad says. Still, he notes, clinicians typically tend to continue the treatment without knowing if they are putting the patients at higher risk.

Ultimately, Gawad adds, the goal is to give patients the minimal amount of treatment with the least toxicity thats possible to cure their disease.

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Cancer progression and harmful bacteria tracked with next-generation sequencing - Chemistry World

Animal Study Workflow Software Market Upcoming Trends, Segmented by Type, Application, End-User and Region -ThernoFisher Scientific, Virtual…

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The report investigates the current status of theAnimal Study Workflow Software Marketand analyses the future trends of the Animal Study Workflow Software market. The report explores the market opportunities available in the Animal Study Workflow Software market. The report assesses the Animal Study Workflow Software market sourced from the currently available data. The report provides in-depth information of the Animal Study Workflow Software market that helps market players understand and analyse the Animal Study Workflow Software industry in terms of key products and services, value-added products, emerging markets, and industries. The report provides basic analysis of the Animal Study Workflow Software market. The report determines the current production and future demand for the products and services, and assists the market players in planning for investment. The report analyses the major exporting and importing producers, overview of the industry, preliminary and secondary assessment of its future potential. The report summarizes the knowledge gaps and recommendations.

Key Players in the Animal Study Workflow Software market:

ThernoFisher Scientific, Virtual Chemistry, Labcat, Instem, Biopticon, IDBS, PDS, VEEVA, Medrio, Dotmatics, Overwatch, DSI, emka, iVENTION, ViewPoint, locus technology, Newlab, Studylog

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The report studies the Animal Study Workflow Software market using cross-sectional multiple regression analysis. The report provides estimates for future market demand. The report also uses secondary analysis to examines the Animal Study Workflow Software market. The report provides detailed analysis Animal Study Workflow Software market value chain. The report analyses the factors affecting the Animal Study Workflow Software market. The report lists the data and trends that studies various components of the Animal Study Workflow Software market. The report reviews the current Animal Study Workflow Software market production and price patterns. The report reviews the production, imports, and profitability segments.

Animal Study Workflow Software Market Types:

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Animal Study Workflow Software Market Applications:

Pharmaceutical companies, Academic institutions, Clinical research organizations, Biotechnology companies

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The report focuses on the key segments and investment planning initiatives. The report primarily discusses the Animal Study Workflow Software industry considering the global scenario and presents different market scenarios to get a clear understanding of the issues and dynamism of this industry. Secondary and primary sources are covered to get relevant information to the market in this report. In pursuit of reliability and relevance, government publications, official websites, news sources, and more are considered in the report.

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4 Stocks to Buy From the Promising Diversified Chemical Industry – Yahoo Finance

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The Zacks Chemicals Diversified industry has recovered after reeling under the effects of the coronavirus fallout. A strong revival in demand in major end markets from the pandemic-led lows and an upturn in manufacturing and industrial activities globally have put the wind back in the sails of the industry.

Dow Inc. DOW, Albemarle Corporation ALB, Huntsman Corporation HUN and The Chemours Company CC are well placed to benefit from the rebound in demand. Strategic measures, including reduction of operating costs, are also helping these companies to navigate a still-challenging environment.

About the Industry

The Zacks Chemicals Diversified industry consists of manufacturers of basic chemicals, plastics, specialty chemicals and agricultural chemicals. Companies in this space serve a host of end markets such as automotive, building & construction, transportation, electronics, aerospace and agriculture. Basic chemicals are produced in large quantities, and include petrochemicals and intermediates (such as ethylene, propylene and benzene), polymers (including plastic resins such as polyethylene, polypropylene and polyvinyl chloride), and inorganic chemicals (such as chlorine, caustic soda and titanium dioxide). Specialty chemicals that include catalysts, specialty polymers and coating additives are used in specific fields based on their performance. Agricultural chemicals include herbicides, fungicides and insecticides that are used to protect crops from disease, pests and weeds.

What's Shaping the Future of the Chemicals Diversified Industry?

Strong End-Market Demand Buoy Prospects: Lockdowns and restrictions by governments around the world, in response to the pandemic, halted industrial activities through the first half of 2020 and gutted demand for chemicals in the key end-use markets, including automotive, construction and electronics. However, chemical demand started to pick up from the third quarter of 2020 on the return of global economic activities. The uptick in demand is being driven by a rebound in manufacturing and industrial activities globally. The automotive industry has rebounded, following the virus-led slump riding on pent-up demand and the shift toward private transportation. Despite the semiconductor crunch still hurting production, diversified chemical companies are seeing firm demand from the automotive market. The construction sector has also bounced back on the resumption of many projects, with strength particularly being witnessed in residential construction. A recovery in demand is also being witnessed across the aerospace and energy markets. An upturn in drilling activities on the back of a surge in oil prices has led to an uptick in demand in the energy space. As the major end-use markets gain further strength, demand for chemicals is expected to go up, thereby driving sales volumes and top lines of diversified chemical companies.

Strategic Actions to Drive Results: The companies in this space are taking a host of strategic measures, including cost-cutting and productivity improvement, operational efficiency improvement and actions to strengthen the balance sheet and boost cash flows. In particular, the industry participants are aggressively implementing actions to bring down costs, which include the reduction of discretionary spending and traveling expenses. The industry players are also raising selling prices to counter cost inflation. These moves are likely to help the industry in sustaining margins amid the prevailing challenges.

Higher Input Costs Pose Margin Headwinds: The industry players are exposed to cost pressure associated with raw materials resulting from short supply. These companies also face challenges arising from higher supply chain and logistics costs. The pandemic-driven disruptions in the supply chain have pushed up the prices of inputs. Russia's invasion of Ukraine and new government-mandated lockdowns in China have also put more pressure on the already strained global supply chain. The impacts of supply and logistic bottlenecks are expected to continue over the short term. Higher raw material and logistics costs are, thus, likely to drag the margins of diversified chemical companies.

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Zacks Industry Rank Indicates Upbeat Prospects

The Zacks Chemicals Diversified industry is part of the broader Zacks Basic Materials sector. It carries a Zacks Industry Rank #97, which places it at the top 38% of more than 250 Zacks industries.

The groups Zacks Industry Rank, which is basically the average of the Zacks Rank of all the member stocks, indicates a bright near term. Our research shows that the top 50% of the Zacks-ranked industries outperforms the bottom 50% by a factor of more than 2 to 1.

Before we present a few stocks that you may want to consider for your portfolio, lets take a look at the industrys recent stock-market performance and valuation picture.

Industry Underperforms S&P 500

The Zacks Chemicals Diversified industry has underperformed the Zacks S&P 500 composite over the past year while outperforming the broader Zacks Basic Materials sector over the same period.

The industry has lost 8.1% over this period compared with the S&P 500s decline of 6.1% and the broader sectors decline of 11.3%.

Industry's Current Valuation

On the basis of the trailing 12-month enterprise value-to EBITDA (EV/EBITDA) ratio, which is a commonly used multiple for valuing chemical stocks, the industry is currently trading at 6.63X, below the S&P 500s 12.38X and above the sectors 5.97X.

Over the past five years, the industry has traded as high as 13.28X, as low as 5.27X and at the median of 8.03, as the chart below shows.

4 Chemicals Diversified Stocks to Keep a Close Eye on

Albemarle: North Carolina-based Albemarle is a premier specialty chemicals company with leading positions in attractive end markets globally. It is benefiting from higher volumes in its lithium business on continued recovery in global economic activities. Healthy customer orders and plant productivity improvements are supporting volumes. Higher lithium prices due to tight market conditions are also supporting its performance. Its bromine business is also gaining from higher demand, a rebound in certain end markets, higher pricing and cost-saving actions. ALB is seeing strong demand for flame retardants. The company is also strategically executing its projects aimed at boosting its global lithium derivative capacity. It remains focused on investing in high-return projects to drive productivity. Albemarle is also benefiting from cost-saving and productivity initiatives.

Albemarle, currently sporting a Zacks Rank #1 (Strong Buy), has expected earnings growth of 175% for the current year. The Zacks Consensus Estimate for ALBs current-year earnings has been revised 85.8% upward over the last 60 days. The company has also surpassed the Zacks Consensus Estimate in each of the trailing four quarters, the average being 22.5%. You can see the complete list of todays Zacks #1 Rank stocks here.

Dow: Based in Michigan, Dow is a material science company, providing a world-class portfolio of advanced, sustainable and leading-edge products. It is benefiting from cost synergy savings and productivity initiatives along with its investment in high-return projects. The company focuses on maintaining cost and operational discipline. Its restructuring program is also expected to deliver margin benefits. DOW also remains committed to investing in attractive areas through highly accretive projects. It is also benefiting from higher demand for its materials across a number of markets, including personal care, electronics, construction, healthcare and packaging.

Dow currently carries a Zacks Rank #2 (Buy). The consensus estimate for current-year earnings has been revised 18.8% upward over the last 60 days. DOW has also surpassed the Zacks Consensus Estimate in each of the trailing four quarters, the average being 9.2%.

Huntsman: Texas-based Huntsman is a leading manufacturer of differentiated and commodity chemical products. Huntsman remains focused on growing its downstream specialty and formulation businesses. The company's Polyurethanes segment is well positioned for strong upside in the long term on the back of its focus on ramping up its high-value differentiated downstream portfolio. HUN should also gain from significant synergies of acquisitions. Its strong liquidity and balance sheet leverage gives it adequate flexibility to continue to develop and expand its core businesses through acquisitions and internal investments.

Huntsman, carrying a Zacks Rank #2, has an expected earnings growth rate of 22.6% for the current year. The consensus estimate for HUN's current-year earnings has been revised 8.5% upward over the last 60 days. The company beat the Zacks Consensus Estimate for earnings in each of the last four quarters at an average of 12.6%.

Chemours: Based in Delaware, Chemours is a leading provider of performance chemicals. Chemours is benefiting from a rebound in demand from the coronavirus-led downturn, strong execution and its cost-cutting actions. It is witnessing increasing adoption of the Opteon platform. Demand for Opteon remains strong in mobile and stationary applications. CCs cost-reduction program along with its productivity and operational improvement actions across its businesses are also expected to support margins.

Chemours, a Zacks Rank #2 stock, has expected earnings growth of 30.5% for the current year. The Zacks Consensus Estimate for earnings for the current year has been revised 15.2% upward over the last 60 days. CC beat the Zacks Consensus Estimate in three of the trailing four quarters. In this time frame, it has delivered an average earnings surprise of roughly 28.7%.

Want the latest recommendations from Zacks Investment Research? Today, you can download 7 Best Stocks for the Next 30 Days. Click to get this free report Dow Inc. (DOW) : Free Stock Analysis Report Albemarle Corporation (ALB) : Free Stock Analysis Report Huntsman Corporation (HUN) : Free Stock Analysis Report The Chemours Company (CC) : Free Stock Analysis Report To read this article on Zacks.com click here. Zacks Investment Research

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4 Stocks to Buy From the Promising Diversified Chemical Industry - Yahoo Finance

Crawford, Frazier have built-in chemistry – MLB.com

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This story was excerpted from Daniel Kramers Mariners Beat newsletter. To read the full newsletter, click here. Andsubscribeto get it regularly in your inbox.

If it looks like theres already chemistry between J.P. Crawford and Adam Frazier, its because this isnt their first rodeo manning a middle infield together.

The scene was the 2015 Arizona Fall League, where Crawford, then just 20 years old in the Phillies organization, and Frazier, age 23 in the Pirates system, teamed up for the Glendale Desert Dogs. Both played shortstop, the position they were brought up playing and where Crawford has remained. Frazier, who also came up in left field, didnt shift primarily to second base until 2018, well after hed reached the Majors.

That powwow nearly seven years ago -- when they were still far from the big leagues -- was short-lived but long-lasting for the admiration it built between the two. So when Crawford learned that the Mariners had traded for Frazier in November, he was stoked to reunite with his former teammate.

I just thought it would be cool to play with him up the middle in the big leagues one day, and here we are, Crawford said. So it's kind of a small world. I was hyped. The guy is a competitor. Hes a gamer.

The feeling was mutual. Frazier was an above-average defender for the Pirates, worth nine outs above average during his time there, but as a team, Pittsburghs infield ranked 22nd, at -29. His new double-play partner is a Gold Glove winner, plays every day when healthy and has zero tolerance for sloppy defense.

His attention to detail -- he stays on top of it and makes sure you are paying attention to detail so youre getting better every day instead of just going through the motions, Frazier said of Crawford. Thats his thing.

Through the weekend, theyve turned nine double plays and have looked smooth doing it.

The feeds that J.P. is giving [Frazier] at the back of the bag, they're up in the right spot, so it's easy to turn a double play, manager Scott Servais said. And Adam has got plenty of arm strength to complete those plays, but it's all in the feed.

You start putting that feed in different parts of his body, and all of a sudden, now he's off balance and it doesn't work. That's why you practice over and over and over again, and the casual fan just says, Its a double-play ball, it should be turned. But there's a lot that goes into it. Our guys do a really good job at it.

The Mariners havent had a true second baseman to pair with Crawford since Dee Strange-Gordon left after 2019, and Frazier is only under contract for '22. But the Mariners front office loves Fraziers offensive approach, hes been an on-base machine batting leadoff and he can play left field. Add those up and he might be a strong candidate for an extension much like Crawford, who on Opening Day signed a five-year deal.

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Crawford, Frazier have built-in chemistry - MLB.com

3-Chloropropene Market- increasing demand with Industry Professionals: Dow Chemical, Solvay, NAMA Chemicals, Hanwha Chemical, Formosa Plastics, etc …

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3-chloropropene-market

Glob Market Reports offers an overarching research and analysis-based study on, Global 3-Chloropropene Market Report, History and Forecast 2016-2028, Breakdown Data by Companies, Key Regions, Types and Application. This report offers an insightful take on the drivers and restraints present in the market. 3-Chloropropene data reports also provide a 5 year pre-historic and forecast for the sector and include data on socio-economic data of global. Key stakeholders can consider statistics, tables & figures mentioned in this report for strategic planning which lead to success of the organization. It sheds light on strategic production, revenue, and consumption trends for players to improve sales and growth in the global 3-Chloropropene Market.

Some of the key manufacturers operating in this market include: Dow Chemical, Solvay, NAMA Chemicals, Hanwha Chemical, Formosa Plastics, Momentive Specialty Chemicals, Sumitomo Chemical, Tamilnadu Petroproducts, LOTTE Fine Chemical, Aditya Birla Chemicals, Shandong Haili Chemical Industry, Jiangsu Yangnong Chemical, Ningbo Huanyang Chemicals, Jiangsu Haixing, Dongying Liancheng and More

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Here, it focuses on the recent developments, sales, market value, production, gross margin, and other significant factors of the business of the major players operating in the global 3-Chloropropene Market. Players can use the accurate market facts and figures and statistical studies provided in the report to understand the current and future growth of the global 3-Chloropropene market.

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Market split by Type, can be divided into: Above 99.9% 99.8%~99.9% 99.5%~99.8%Market split by Application, can be divided into: Home Appliance Coating Others

Regions Covered in the Global 3-Chloropropene Market:1. South America 3-Chloropropene Market Covers Colombia, Brazil, and Argentina.2. North America 3-Chloropropene Market Covers Canada, United States, and Mexico.3. Europe 3-Chloropropene Market Covers UK, France, Italy, Germany, and Russia.4. The Middle East and Africa 3-Chloropropene Market Covers UAE, Saudi Arabia, Egypt, Nigeria, and South Africa.5. Asia Pacific 3-Chloropropene Market Covers Korea, Japan, China, Southeast Asia, and India.Years Considered to Estimate the Market Size:History Year: 2015-2022Base Year: 2022Estimated Year: 2022Forecast Year: 2022-2028

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3-Chloropropene Market- increasing demand with Industry Professionals: Dow Chemical, Solvay, NAMA Chemicals, Hanwha Chemical, Formosa Plastics, etc ...

‘A conversation that inspires’: Princeton brings landmark discoveries in chemistry to high school students – Princeton University

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When Assistant Professor of Chemistry Ralph Kleiner set out to tell the story of landmark discoveries in chemical biology, he kept one goal foremost in mind: make it compelling.

This month, he and his research group met that goal with a series of videos for high school students. Backed by the able narration of graduate student Emilia Argello, the videos use primary literature to highlight some of chemistrys historic achievements in nucleic acid science.

Ralph Kleiner (left) and his research team are creating a series of short videos for high school students. The videos, which feature graduate student Emilia Argello (right), use primary literature to highlight historic achievements in DNA and RNA science.

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C. Todd Reichart, Department of Chemistry

The videos are available through the Department of Chemistrys Vimeo channel and the Kleiner Lab website. The first two in the series are The Transforming Principle and Discovering the Structure of DNA.

Engaging and conversational as they are informative, these two videos also fulfill part of the terms of Kleiners 2019 CAREER Award. The National Science Foundation, which stewards the award, requires a strong commitment to outreach and education.

When I wrote the outreach portion of the CAREER proposal, my goal was to introduce students to the scientific method through exposure to the primary literature, said Kleiner. Reading original scientific manuscripts is not only an essential part of research, but it can bring the material to life by infusing it with the personality, history and circumstances of the scientists who made the discoveries.

The lab plans to produce up to 10 videos in the series.

Argello, whose research focuses on investigating the interactions of proteins with modified RNA, was tasked with selecting, organizing and translating the information for the first two videos.

Im very adamant about being conversational in my talks, even if its an official talk, said Argello. I have to feel that Im engaging with the audience. Some people say, Im never going to understand chemistry; its too arcane. But no we can unpack these concepts and have a conversation that inspires people.

Read the full story on the Department of Chemistry website.

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'A conversation that inspires': Princeton brings landmark discoveries in chemistry to high school students - Princeton University

New Explosive Compound Synthesized From Strange World of High-Pressure Chemistry – SciTechDaily

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Explosion animation artists concept.

Researchers from Skoltech, Carnegie Institution of Washington, Howard University, the University of Chicago, and the Chinese Academy of Sciences Institute of Solid State Physics have synthesized K2N6, an exotic compound containing N6 groups and packing explosive amounts of energy. While the team had to create synthesis pressures several times higher than it would take to make the material useful outside the lab as an explosive or rocket propellant, the experiment to be published today (April 21, 2022) in Nature Chemistry takes us one step closer to what would be technologically applicable.

Nitrogen is at the heart of most chemical explosives, from TNT to gunpowder. The reason for this is that a nitrogen atom has three unpaired electrons itching to form chemical bonds, and combining two such atoms in an N2 molecule in which the atoms share three electron pairs is by far the most energy-efficient way of scratching that itch. This means that compounds with a lot of nitrogen atoms engaged in other, less energetically advantageous bonds are always on the verge of an explosive reaction that produces N2 gas.

Microphotographs of laser-heated potassium azide samples at pressures of 500,000 atmospheres (left) and 300,000 atmospheres (right). The white to light-blue areas on the outside are K1N3. Toward the center, the material has transformed into K2N6 in the left photo and a mysterious and poorly understood compound with the formula K3(N2)4 on the right. Credit: Yu Wang et al./Nature Chemistry

Professor Artem R. Oganov of Skoltech, who was responsible for the calculations in the study reported in this story, comments: An idea has existed for a long time that pure nitrogen could be the ultimate chemical explosive if synthesized in a form containing no N2 molecules. And indeed, prior research has shown that at pressures of over 1 million atmospheres, nitrogen does form structures where any two adjacent atoms only share one electron pair, not three.

While such exotic nitrogen crystals certainly could explode, reverting to the familiar triple-bonded N2 gas, their synthesis requires pressures that are too high for any practical applications. This leads researchers to experiment with other nitrogen-rich compounds, such as the one obtained for the first time in the study published today, led by Carnegies Alexander F. Goncharov.

The compound we synthesized is called potassium azide and has the formula K2N6. Its a crystal created at a pressure of 450,000 atmospheres. Once formed, it can persist at about half that pressure, says Alexander Goncharov, a staff scientist at Carnegie Institution of Washington, where the experiment was run. In that crystal, the nitrogen atoms assemble into hexagons, where the bond between each two adjacent nitrogens is intermediate between a single and a double bond. The structure of our compound consists of these hexagons alternating with individual potassium atoms that stabilize the nitrogen rings, which are the really interesting part.

The scientists admit that the new material falls short of practical applications, because the synthesis pressure required is still too high 100,000 atmospheres would be more realistic but it certainly constitutes a step in the right direction and offers exciting fundamental chemistry insights.

This new high energy density material is another example of the peculiar chemistry of high pressures, Oganov says, adding that his recently published study (read more), which revamped the fundamental notion of electronegativity making it applicable under pressure, is a useful framework for making sense of the unusual nitrogen-rich materials, along with other exotic compounds spanning the entire periodic table of elements.

Reference: Stabilization of hexazine rings in potassium polynitride at high pressure by Yu Wang, Maxim Bykov, Ilya Chepkasov, Artem Samtsevich, Elena Bykova, Xiao Zhang, Shu-qing Jiang, Eran Greenberg, Stella Chariton, Vitali B. Prakapenka, Artem R. Oganov and Alexander F. Goncharov, 21 April 2022, Nature Chemistry.DOI: 10.1038/s41557-022-00925-0

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New Explosive Compound Synthesized From Strange World of High-Pressure Chemistry - SciTechDaily