Research and Markets: Neurology – Pipeline Review, H2 2012

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DUBLIN--(BUSINESS WIRE)--

Research and Markets (http://www.researchandmarkets.com/research/p29fp6/neurology) has announced the addition of Global Markets Direct's new report "Neurology - Pipeline Review, H2 2012" to their offering.

Global Markets Direct's, 'Neurology - Pipeline Review, H2 2012', provides an overview of the indication's therapeutic pipeline. This report provides information on the therapeutic development for Neurology, complete with latest updates, and special features on late-stage and discontinued projects. It also reviews key players involved in the therapeutic development for Neurology.

Scope

- A snapshot of the global therapeutic scenario for Neurology.

- A review of the Neurology products under development by companies and universities/research institutes based on information derived from company and industry-specific sources.

- Coverage of products based on various stages of development ranging from discovery till registration stages.

- A feature on pipeline projects on the basis of monotherapy and combined therapeutics.

- Coverage of the Neurology pipeline on the basis of route of administration and molecule type.

- Key discontinued pipeline projects.

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Research and Markets: Neurology - Pipeline Review, H2 2012

FND a Crisis for Neurology -Neuro Film Festival .m4v – Video

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FND a Crisis for Neurology -Neuro Film Festival .m4v
Little is known or understood about FND. It can be as debilitating as Parkinson #39;s and MS yet because of the lack of research its actual prevalence is not even known. There are not effective treatment plans, many around the world are sent home to suffer in silence with hopes it will go away on its own. People with this disorder often loose the ability to walk, experience extreme pain, muscle spasm or weakness, dystonic movements, non-epeleptic seizures and some must self catheter. There is a common occurrence of physical triggering events such as illness or injury prior to onset. Women are most often effected. "This film has been entered into the 2013 Neuro Film Festival from the American Brain Foundation at http://www.NeuroFilmFestival.com. Let #39;s put our brain #39;s together to cure brain disease. Visit CureBrainDisease.org" On behalf of The Morning Chorus, it would be a fantastic opportunity to have our song "The Burden" featured on your Functional Neurological Disorder / CD Awareness video for the ABF (American Brain Foundation). http://www.facebook.com/TheMorningChorus

By: Bridget Hope

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FND a Crisis for Neurology -Neuro Film Festival .m4v - Video

Quantum Neurology® with Dr. David Pascal 1/2 – Video

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Quantum Neurology® with Dr. David Pascal 1/2
Dr. George Gonzalez the founder of Quantum Neurology® Nervous System rehabilitation interviews Dr. David Pascal DC. He was the first doctor certified in Quantum Neurology and has had tremendous results applying Nervous System rehabilitation to elite athletes and severely damaged patients. For more information about learning Quantum Neurology or seeing a practitioner please visit our website: http://www.QuantumNeurology.com

By: George Gonzalez

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Quantum Neurology® with Dr. David Pascal 1/2 - Video

Quantum Neurology® with Dr. David Pascal 2/2 – Video

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Quantum Neurology® with Dr. David Pascal 2/2
Dr. George Gonzalez the founder of Quantum Neurology® Nervous System rehabilitation interviews Dr. David Pascal DC. He was the first doctor certified in Quantum Neurology and has had tremendous results applying Nervous System rehabilitation to elite athletes and severely damaged patients. For more information about learning Quantum Neurology or seeing a practitioner please visit our website: http://www.QuantumNeurology.com

By: George Gonzalez

More here:
Quantum Neurology® with Dr. David Pascal 2/2 - Video

Seasonal affective disorder (SAD)

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What is seasonal affective disorder?

Seasonal affective disorder is a combination of biologic and mood disturbances with a seasonal pattern. It typically occurs in the autumn (fall) and winter, with remission in the spring or summer.

How common is seasonal affective disorder?

5% of the U.S. population experiences seasonal affective disorder. Because the symptoms are seasonal, they are present for 40% of the year. Although the condition is seasonally limited, patients may have associated depression which would last longer.

What is the treatment for seasonal affective disorder?

Light therapy is well tolerated. Most patients improve within 1-2 weeks. To avoid relapse, light therapy should continue through the end of the winter season until spontaneous remission of symptoms in the spring or summer.

Antidepressant medications and cognitive behavior therapy are as effective as light therapy.

How to prevent seasonal affective disorder?

Light treatment may be used as prophylaxis before the subsequent autumn and winter seasons.

There are many devices available on Amazon, for example:

References:

Seasonal affective disorder. Kurlansik SL, Ibay AD. Am Family Physician, Dec 2012.
Image sources: Record breaking snowfall March 2008 at Aubrey, Texas, Wikipedia, public domain

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Why would a person have pink sweat (chromhidrosis)?

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Pink sweat is typically due to chromhidrosis (colored sweat).

What is chromhidrosis?

Chromhidrosis is a rare condition characterized by the secretion of colored sweat. Approximately 10% of normal people have colored sweat (without chromhidrosis).

Two glands produce sweat:

- Eccrine glands secrete a clear, odorless fluid that regulates body temperature.

- Apocrine glands secrete a thick, milky sweat that, once broken down by bacteria, is the main cause of body odor (smell).

Which glands are responsible for chromhidrosis?

- Chromhidrosis is caused mainly by the apocrine glands. They are located in the genital, axillary, areolar, and facial skin. Chromhidrosis is reported only on the face, axillae, and breast areola.

- Eccrine chromhidrosis is rare and occurs with ingestion of certain dyes or drugs.

- Pseudochromhidrosis occurs when clear eccrine sweat becomes colored on the surface of the skin as a result of extrinsic dyes, paints, or chromogenic bacteria.

What is the pigment in chromhidrosis?

Lipofuscin is a yellowish brown pigment that is responsible for the colored sweat. Lipofuscin is produced in the apocrine glands, and its various oxidative states account for the characteristic yellow, green, blue, or black secretions in chromhidrosis.

Are any lab tests indicated?

No laboratory abnormalities are typically found in apocrine chromhidrosis. The following test may help to rule out other causes:

- complete blood cell count (CBC) to exclude bleeding diathesis
- urinary homogentisic acid levels to exclude alkaptonuria
- fungal and bacterial cultures to exclude infectious causes of pseudochromhidrosis

How to treat chromhidrosis?

Apocrine chromhidrosis has no cure. Patients can manually or pharmacologically empty the glands to remove the color for 48-72 hours (until the glands replenish the pigment).

Botox® injections have been attempted in chromhidrosis, with mixed results. Botox is predominantly used to decrease eccrine sweat in persons with hyperhidrosis.

Capsaicin cream (alkaloid found in chilly peppers) also can help.

References:

Chromhidrosis - Medscape http://bit.ly/UmhTXU
Facial and axillary apocrine chromhidrosis http://bit.ly/UmhV1Q
Treating Chromhidrosis - Discovery Health http://bit.ly/UmhVPE
Image source: Sweat, Shaylor's photostream, Creative Commons license. The image is not related and does not show a patient.

Comments from Twitter:

Laura VR Bertotto @LauraAtVMV: Botox has worked well for hyperhydrosis. This is interesting.

Dr. Claudia Aguirre @doctorclaudia: Interesting.

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Chiropractic Neurology: Dr Carrick on ABC News – Video

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Chiropractic Neurology: Dr Carrick on ABC News
An insight at the possibilities of Chiropractic (Functional) Neurology with Prof Carrick, the founder of this expanding discipline of health care. Harnessing the power of neuroplasticity with a strong understanding of neuroanatomy, neurophysiology and the latest research, Chiropractic Neurology has plenty to offer those people suffering from a range of neurological conditions, such as balance disorders, stroke, migraines, learning and behavioural disorders, and many more. To find out more, visit http://www.liveactivelinic.com.au or visit us at Facebook http://www.facebook.com

By: Carlo Rinaudo

Excerpt from:
Chiropractic Neurology: Dr Carrick on ABC News - Video

Top Foods for Longevity (video)

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This video from About.com will go over some of "the top foods to eat or longevity."

There are some other useful videos from About.com YouTube channel neatly arranged in playlists: http://bit.ly/VU8nbZ

Here is a related playlist: Super Foods http://bit.ly/VILPLc

Interesting Correlation: Fast Food Founders and Longevity

By the way, Jay Parkinson noted an interesting correlation between Fast Food Founders and Longevity:

- Ray Kroc (McDonald’s) died at age 82
- Jimmy Dean died at age 81
- Taco Bell founder Glen Bell died at 86
- Sonic founder Troy Smith died at 87
- Hardee’s founder Wilber Hardee died at 89
- Baskin-Robbins founder Irvine Robbins died at 90
- Carl’s Jr. founder Carl Karcher died at 90
- Frozen french fry mogul J.R. Simplot died at 99
- Murray Handwerker, credited with making Nathan’s Famous Hot Dogs into a well-known national chain, died at 89

Standard American Diet (Yes, it’s SAD)

The average American consumes 45 gallons of soft drinks annually. This does not include noncarbonated sweetened beverages, which add up 17 gallons a person per year. Chips and Coke are a common breakfast.

Cheap fast food is "enticing people to eat more because they think they're saving money when they're really buying heart disease", says Jillian Michaels.

We can do better

One step is to grow your own vegetables, even on a small scale. Chicago is already doing that. See for yourself: How Google Earth Revealed Chicago's Hidden Farms - NPR http://n.pr/VU8NyO

There are some helpful Tools for Your Food Revolution - Wolfram|Alpha Lets You Compare Nutritional Value of Foods.

See the passion of an urban gardener here, at 3:33 min: http://bit.ly/RZfWSD

The whole video is here:

The Grow video series by Whole Foods has at least 7 episodes - you can search for them on YouTube: http://bit.ly/RZgaJu

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Top medicine articles for December 2012-January 2013

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Here are my suggestions for some of the top articles in medicine for December 2012-January 2013:

Among former Olympic athletes, engagement in disciplines with high intensity exercise did not bring a survival benefit http://buff.ly/UmY9Ur

Non-benzodiazepine hypnotics (Z drugs - eszopiclone, zaleplon, zolpidem) are effective for treatment of adult insomnia http://buff.ly/UZC1g9

Bringing surgical history to life | BMJ http://buff.ly/UZCeQC -- Things change fast in surgery. Within a single generation, ways of operating that had been stable for decades have been overturned. New drugs have revolutionized what were once “surgical” conditions, and minimally invasive procedures have driven many “open” operations to the verge of extinction.

Dabigatran Shouldn't Be Used in Patients with Mechanical Heart Valves http://buff.ly/UmXToo

Confront medical errors - The University of Michigan Health System pioneered the three principle approach of “disclose, apologize, offer” more than a decade ago. http://buff.ly/UZDeV0

One Question That Changed the Cleveland Clinic Organization:
"How do you teach empathy?" CEO explains: http://buff.ly/V1ntgi

Too Young to Have a Heart Attack, at 48 - NYTimes http://buff.ly/UvpYKd

The Perils of Yoga for Men - torn muscles, damaged ligaments, dislocated joints, broken bones http://buff.ly/UwxhBp

Doctor Sued for Following a 'Do Not Resuscitate Order (found not liable by the jury) http://buff.ly/UZzYZH

Consequence of prescription-pain-pill epidemic: babies born dependent on drugs such as oxycodone http://buff.ly/V80BvE

50% of new experimental treatments prove to be better than established treatments, but few are much better http://buff.ly/PLDqJt

Exercise Minutes Per Week as a Vital Sign? http://buff.ly/11aAHxp

Asleep at the Wheel: 'Drowsy Driving' affects 4% of survey responders http://buff.ly/11aAQRg

Some U.S. Few Medical Schools Now Offering 3-Year Degrees http://buff.ly/WrCSoC

The articles were selected from my Twitter and Google Reader streams. Please feel free to send suggestions for articles to clinicalcases AT gmail.com and you will receive acknowledgement in the next edition of this publication.

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Age-related macular degeneration – 2012 Lancet review

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From the The Lancet:

Age-related macular degeneration is a major cause of blindness worldwide. With ageing populations in many countries, more than 20% might have the disorder.

Advanced age-related macular degeneration is associated with progressive visual impairment. It includes two subtypes:

- neovascular age-related macular degeneration (wet)
- geographic atrophy (late dry) macular degeneration

What are the risk factors for macular degeneration?

Major risk factors include:

- cigarette smoking
- nutritional factors
- cardiovascular diseases
- genetic markers, including genes regulating complement, lipid, angiogenic, and extracellular matrix pathways

How to diagnose macular degeneration?

Accurate diagnosis combines clinical examination and investigations including:

- retinal photography
- angiography
- optical coherence tomography

What is the treatment for macular degeneration?

Dietary anti-oxidant supplementation slows progression of the disease.

Treatment for neovascular age-related (wet) macular degeneration includes intraocular injections of anti-VEGF agents. The two commonly used anti-VEGF therapies, ranibizumab and bevacizumab, have similar efficacy.

Future treatments include inhibition of other angiogenic factors, and regenerative and topical therapies.

References:

Age-related macular degeneration. The Lancet, Volume 379, Issue 9827, Pages 1728 - 1738, 5 May 2012.
Image source: Wikimedia Commons.

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