Researchers Switch Off Gene in Mice to Switch on Endurance | 80beats

spacing is important

What’s the News: By knocking out a single gene, scientists at the University of Pennsylvania have significantly increased the physical endurance of lab mice, as explained in their recent paper in the Journal of Clinical Investigation. The researchers also found that certain variants of the same gene may be linked to greater endurance in humans.

How the Heck:

Past in vitro studies showed that a gene called IL-15R? is involved in controlling muscle contractions, which play a role in both muscle strength and endurance. But the gene has never been studied in a living animal, so physiologist Tejvir Khurana and his research team decided to engineer lab mice that lack IL-15R?.
They noticed that at night the altered mice ran six times farther than normal mice. When the team dissected the engineered mice, they found that their muscles had more fibers than normal mice, as well as a higher number of mitochondria, the power plants of cells. ...


Atlantis launch in 3D | Bad Astronomy

Tomorrow morning, July 21, at 5:56 a.m. EDT (09:56 GMT), the Space Shuttle Orbiter Atlantis is scheduled to set wheels down on Earth one last time. When it launched, though, pictures were taken as the rocket rolled that allowed Nathaniel Burton-Bradford to create a 3D red/cyan anaglyph:

[Click to enlaunchenate.]

I posted another 3D image he made of Atlantis, too, and he has one of the ISS he just made as well. If you don’t have red/cyan glasses, you can search for ‘em online. They’re pretty cheap, and I do sometimes link to pictures like this… like in Related Posts below. It’s totally worth a buck, just for that moment of "wow".

Credit: NASA, Nathanial Burton Bradford

Related posts:

- 3D Apollo
- The lumpy, 3D Earth
- Phobos is, like, totally groovy
- 3D House of Comet Nucleus


Children share when they work together, chimps do not | Not Exactly Rocket Science

We are a cooperative ape, and a fair one. We work together to put food on the table and once it’s there, social rules compel us to share it around equitably. These two actions are tied to one another. In a new study, Katharina Hamann from the Max Planck Institute for Evolutionary Anthropology has shown that three-year-old children are more likely to fairly divide their spoils with other kids if they’ve worked together to get them.

The same can’t be said of chimpanzees, one of our closest relatives. Sharing comes less naturally to them, and it doesn’t become any more likely if they’ve worked together to get a meal.

Hamann says, “Among great apes, only humans are true collaborative foragers.” Other species might look for food together, but being next to one another is not the same as working together. The only exception are the hunting parties of chimps, where several individuals work together to kill monkeys for food. The slain monkeys are shared, but either under duress or in exchange for favours.

With children, things are very different. Studies have shown that children as young as five to seven start ...

NASA Astrophysics: It Really Is This Bad | Cosmic Variance

Shorter House of Representatives: NASA shouldn’t do astrophysics anymore. Via the Tracker, an article by Eric Hand in Nature News that puts the fiasco in helpful graphical form.

Misleading graphic alert! The vertical scale starts at $0.5 billion, not at $0. But taking that into account merely changes the situation from “complete annihilation” to “devastating harm.” We’re talking about a 40% cut, which won’t leave room to do much more than keep the lights on for existing programs.

The 2011 numbers are the President’s budget request; the 2012 numbers are from the bill that passed the House. This isn’t yet law, so there’s still time; the Senate and the White House will (thankfully) be involved in the final compromise.

Times are tough, and not everything is worth doing. But there are few things more important to the long-term flourishing of a country than investment in basic science. Sad to see the future sacrificed for bizarre political reasons.


GAO on Parts Quality Problems at DoD and NASA

Space and Missile Defense Acquisitions: Periodic Assessment Needed to Correct Parts Quality Problems in Major Programs, GAO

"Quality is key to success in U.S. space and missile defense programs, but quality problems exist that have endangered entire missions along with less-visible problems leading to unnecessary repair, scrap, rework, and stoppage; long delays; and millions in cost growth. For space and missile defense acquisitions, GAO was asked to examine quality problems related to parts and manufacturing processes and materials across DOD and NASA. DOD and NASA should implement a mechanism for periodic assessment of the condition of parts quality problems in major space and missile defense programs with periodic reporting to Congress. DOD partially agreed with the recommendation and NASA agreed. DOD agreed to annually address all quality issues, to include parts quality."

Being Clear As To Who Actually Cancelled The Shuttle

Statement by Gov. Rick Perry on Final Landing of Shuttle Atlantis

"Unfortunately, with the final landing of the Shuttle Atlantis and no indication of plans for future missions, this administration has set a significantly different milestone by shutting down our nation's legacy of leadership in human spaceflight and exploration, leaving American astronauts with no alternative but to hitchhike into space."

Perry launches on Obama for cutting NASA, Dallas News

"... Perry went on to say that, "this administration has set a significantly different milestone by shutting down our nation's legacy of leadership in human spaceflight and exploration, leaving American astronauts with no alternative but to hitchhike into space." Actually, it was the Bush Administration that decided to end shuttle missions, and the Obama Administration extended the life of the shuttle program by adding two additional flights."

President Bush Announces New Vision for Space Exploration Program, White House

"The Shuttle's chief purpose over the next several years will be to help finish assembly of the International Space Station. In 2010, the Space Shuttle -- after nearly 30 years of duty -- will be retired from service."

Rejoice Comrades! Glorious Era of Soyuz Begins (Update)

Russia declares 'era of Soyuz' after shuttle, AFP

"Mankind acknowledges the role of American space ships in exploring the cosmos," it added. But Roskosmos also used the occasion to tout the virtues of the Soyuz (Union) spacecraft, which unlike the shuttle lands on Earth vertically with the aid of parachutes after leaving orbit. It said that there was a simple answer to why the Soyuz was still flying after the shuttles retired -- "reliability and not to mention cost efficiency."

Keith's note: How nice of our friends at Roskosmos to rub our noses in their monopoly today. Oh well, we created this situation through both deliberate intent and bumbling over the past decade. Well played, comrades. Enjoy it while it lasts. By overcharging in the obscene, escalating fashion that you have done during our periods of need, you are sowing the seeds of your own demise by spurring lower cost alternatives. All too soon, American spacecraft will do everything Soyuz does - and more - and will do so much better - and cheaper.

Keith's update: Yea, in case you had not noticed, I am really pi**ed off by this whole situation and how the Russians (whose space program we overtly subsidized since the 1990s) are dancing in response to our bad decisions and crappy predicament. Oh well, it will be fun to watch Russia wiggle as China flies the real Soyuz upgrades - and then as SpaceX et al beat Russia and China on both price and performance.

How Congressional Budget Uncertainties Affect Science

Exobiology 2010 Update #4

"As you know, federal spending is under intense scrutiny. In addition, the timing of the federal budget review and approval process has been less than ideal. These developments have affected our ability to manage Astrobiology Program funds as effectively as we would like. Over the past decade, the proposal due date for the Exobiology Program has moved from June to August, then to September, and, finally, to October. This shift has moved starting dates for new grants later into the federal fiscal year and thus placed greater budget pressure on the Astrobiology Program."

Looking Back, Looking Forward, and Pointing Fingers

United Launch Alliance Congratulates NASA as Shuttle Ends 30 Years of Spaceflight

"In addition, under the Commercial Crew Program, ULA is proud to be the launch vehicle of choice for Sierra Nevada's Dream Chaser and Blue Origin's Space Vehicle, and compete to support Boeing's CST-100 program. Working together with NASA, these established companies and entrepreneurs plan to usher in a bold new era of human spaceflight; not only transporting NASA astronauts to the International Space Station, but opening spaceflight to non-government passengers for the first time."

As Atlantis Lands, Adams Recognizes the Ending of an Era

"NASA's 30-year Space Shuttle Program has been more than just space exploration to Florida families, it's part of their history, it's their livelihoods, and it's been a source of inspiration for the tens of thousands of people who have supported its operations and have made their homes in our great state."

Statement by Gov. Rick Perry on Final Landing of Shuttle Atlantis

"The Obama Administration continues to lead federal agencies and programs astray, this time forcing NASA away from its original purpose of space exploration, and ignoring its groundbreaking past and enormous future potential. It is time to restore NASA to its core purpose of manned space exploration, and to define our vision for 21st Century space exploration, not in terms of what we cannot do, but instead in terms of what we will do."

Shuttle Era Ends

Wheels Stop - As Atlantis Lands the Shuttle Era Comes to an End, SpaceRef

"At 5:57:54 a.m EDT the orbiter Atlantis came to a wheels stop at the Kennedy Space Center runway 15 marking the end of the Space Shuttle era."

NASA Administrator Commemorates Final Space Shuttle Landing, NASA

"At today's final landing of the space shuttle, we had the rare opportunity to witness history. We turned the page on a remarkable era and began the next chapter in our nation's extraordinary story of exploration."

NASA's Proud Space Shuttle Program Ends With Atlantis Landing, NASA

"The brave astronauts of STS-135 are emblematic of the shuttle program -- skilled professionals from diverse backgrounds who propelled America to continued leadership in space with the shuttle's many successes," NASA Administrator Charles Bolden said. "This final shuttle flight marks the end of an era, but today, we recommit ourselves to continuing human spaceflight and taking the necessary- and difficult - steps to ensure America's leadership in human spaceflight for years to come."

Planetary Society Statement On the End of the Space Shuttle Program, Planetary Society

"Mission accomplished! It's been thirty great years for the Space Shuttle program. With this venerable space vehicle retired, it's on to the next adventure.

"The Space Shuttle has taken more than 10,400 tons into orbit, a fantastic legacy, as most of that equipment is still up there helping astronauts do their jobs. But now it's time to move up and on -- outward. We can make new discoveries peering beyond new horizons."

Saying farewell to Atlantis and the Shuttle program in the Mission Control Room in Houston.

Attempts to Save Webb?

Recent Policy Activity on James Webb Space Telescope and Pu-238, AAS

"Rep. Wolf and Rep. Fattah are highly likely to work out a deal to restore JWST funding before the bill goes to the House floor, perhaps involving enhanced language spelling out detailed project oversight requirements. The AAS is pursuing a strategy to directly encourage a solution in the House during floor debate by working with key individual legislators and to secure support from the Senate to restore funding in the Senate version of the FY2012 appropriations."

Official NASA Shuttle Talking Points

NASA Internal Memo: Official Overarching Messages Regarding Shuttle Retirement

"* The Bush Administration in 2004 made the decision to end the Space Shuttle program. President Obama extended the program's life by adding two Space Shuttle launches to the manifest: STS-134, which was funded in the President's FY 2010 Budget Request; and STS-135 which was funded as part of the agreement that the President reached with Congress for FY 2011 funding.

* An independent commission found that the previous Administration's plan for human spaceflight in the post-Shuttle era was not viable under any feasible budget scenario. Among other challenges, it would have left NASA without the ability to get to the International Space Station until after it was de-orbited in 2016, and weakened other important NASA priorities including science, aeronautics, and technology development."

Mike Griffin was against the Space Shuttle before he was for it

Former NASA chief Griffin now wants to save the shuttle, Houston Chronicle

"In his e-mail, Griffin writes:

"At this point I'm in agreement with Dr. Kraft ... In a world of limited budgets, I was willing to retire the shuttle as the price of getting a follow-on system that could allow us to establish a manned lunar base. Not that my opinion matters, but I see no sense in retiring the shuttle in favor of nothing. That is beyond foolish."

It's a pretty stunning reversal from the man who, just a few years ago, couldn't get rid of the shuttle soon enough."

Keith's note: Mike Griffin and his self-described "band of brothers" often referred to the Space Shuttle as an "albatross" and was indeed in a big hurry for it to go away. He seemed to have little worry that the "gap" that he so despised grew rather healthily under his tenure. Now that his self-described "Apollo on Steroids" architecture collapsed under its own flawed engineering and program execution, he's suddenly a space shuttle advocate.

That's the problem with steroids, Mike: they affect both your memory and your judgement.

GAO on Space Research Coordination

Space Research: Content and Coordination of Space Science and Technology Strategy Need to Be More Robust, GAO

"... the National Aeronautics and Space Administration (NASA) and the National Oceanic and Atmospheric Administration (NOAA) together with the intelligence community, conduct a significant amount of space S&T. Although NASA and NOAA participation is not required, DOD may have missed an opportunity to leverage these agencies' activities and optimize its own S&T spending by involving them in strategy development. GAO was also required to evaluate the effectiveness of the coordination mechanisms planned to implement the strategy."

Space Program Cutbacks – One View

American Astronautical Society Statement on Space Program Cutbacks

"The number one long-term issue facing our country's leaders is economic growth, including job creation, GDP growth and increasing the balance of trade. Without a growing economy that creates new high wage jobs, our future is grim. For the private sector to help steward this growth, it needs sustainable, reliable federal budgets and investments by the government in technology innovation across the board, including aerospace. We applaud the House Appropriations Committee for the pace at which it is moving forward with the appropriations bills to fund the fiscal year that begins on October 1. We understand the need to reduce the deficit. But we must not jeopardize our future by dramatic cuts to the central core of our nation's economic development - investments in science and technology, particularly those associated with the space program."

DC-Only Media Event for MSL Landing Site Announcement

NASA Announcing Landing Site For New Mars Rover

"NASA and the Smithsonian's National Air and Space Museum will host a news conference at 10 a.m. EDT, Friday, July 22 to announce the selected landing site for the agency's latest Mars rover. The event will be in the museum's Moving Beyond Earth Gallery. NASA Television and the agency's Web site will provide live coverage of the event."

Keith's note: As one rather prominent space/science to journalist just noted to me: "And in service to the media, there's no accessibility for off-site reporters. Brilliant!"

Force Draw Curve Plotter

I made this machine inspired by Clarence N Hickman's machine made in 1938.
It's used to plot the force/draw curve of bows, his machine used rack and pinion gearing. I don't have much in the way of metal working facilities so I made use of pulleys string and elastic .

Here's a link to a video

Volvo City Safety Cuts Accidents by 27%

From Extremetech:

Here's proof that technology really does make driving safer: Volvos equipped with the automaker's City Safety collision avoidance system are in 27% fewer accidents than comparable vehicles. That's a huge reduction, says the Highway Loss Data Institute (HLDI). City Safet