Bill Gates: Embrace Genetic Modification or Starve

Bill Gates has a terse response to criticism that the high-tech solutions he advocates for world hunger are too expensive or bad for the environment:  Countries can embrace modern seed technology and genetic modification or their citizens will starve.

When he was in high school in the 1960s, people worried there wouldn’t be enough food to feed the world, Gates recalled in his fourth annual letter, which was published online on January 24 and reported on by the AP in the Huffington Post. But the “green revolution,” which transformed agriculture with high-yield crop varieties and other innovations, warded off famine.

Gates is among those who believe another, similar revolution is needed now. The Bill & Melinda Gates Foundation has spent about $2 billion in the past five years to fight poverty and hunger in Africa and Asia, and much of that money has gone toward improving agricultural productivity.

Gates doesn’t apologize for his endorsement of modern agriculture or sidestep criticism of genetic modification. He told the Associated Press that he finds it ironic that most people who oppose genetic engineering in plant breeding live in rich nations that he believes are responsible for global climate change that will lead to more starvation and malnutrition for the poor.

In his 24-page letter, the Microsoft Corp. chairman lamented that more money isn’t spent on agriculture research and noted that of the $3 billion spent each year on work on the seven most important crops, only 10 percent focuses on problems in poor countries.

“Given the central role that food plays in human welfare and national stability, it is shocking – not to mention short-sighted and potentially dangerous – how little money is spent on agricultural research,” he wrote in his letter, calling for wealthier nations to step up.

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Bill Gates: Embrace Genetic Modification or Starve

Opportunities and challenges of palliative care in the ICU discussed in expert roundtable

Public release date: 30-Jan-2012
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Contact: Vicki Cohn
vcohn@liebertpub.com
914-740-2100
Mary Ann Liebert, Inc./Genetic Engineering News

New Rochelle, NY -- If you think palliative care and the ICU don't go together, think again. The importance and potential benefits of palliative care to ease suffering and improve quality of life for patients being treated in hospital intensive care units (ICUs) has received increasing recognition but is not without significant challenges, as discussed in a Roundtable discussion in Journal of Palliative Medicine, a peer-reviewed journal published by Mary Ann Liebert, Inc. (http://www.liebertpub.com). Journal of Palliative Medicine is the Official Journal of the Center to Advance Palliative Care (CAPC) and an Official Journal of the Hospice and Palliative Nurses Association (HPNA). The Roundtable is available free online at http://www.liebertpub.com/jpm

Palliative care in the ICU requires a team effort. A multidisciplinary group of health care experts share their experiences, views, and advice as participants in a roundtable discussion, "Palliative Care in the ICU (http://online.liebertpub.com/doi/full/10.1089/jpm.2011.9599)," led by moderator Judith Nelson, MD, JD, Professor of Medicine and Project Director, The IPAL-ICU Project, Mount Sinai School of Medicine, New York, NY. The participants included: Elie Azoulay, MD, H?pital Saint-Louis, Universit? Paris VII, France; J. Randall Curtis, MD, MPH, Harborview Medical Center, University of Washington, Seattle; Anne Mosenthal, MD, UMDNJ-NJMS, Newark, NJ; Colleen Mulkerin, MSW, LCSW, Hartford Hospital, CT; Kathleen Puntillo, RN, DNSc, University of California, San Francisco; and Mark Siegel, MD, Yale School of Medicine, Yale-New Haven Hospital, CT.

Patients in the ICU are often at high risk of dying and may be on life support or require intensive monitoring. There has been a significant shift in the critical care community toward increasing recognition of the needs of ICU patients and families and the potential for greater use of palliative care to ease their suffering and provide psychological support.

The IPAL-ICU Project of the Center to Advance Palliative Care is supported by the National Institutes of Health and is working to develop recommendations to guide the implementation of palliative care principles and practices in the ICU, focusing on the special issues affecting patients, families, and caregivers in the ICU environment.

"It seems clear that palliative care in the ICU improves the quality of care for both patients and their families. I suspect this will become standard of care in all hospitals in coming years," says Charles F. von Gunten, MD, PhD, Editor-in-Chief of Journal of Palliative Medicine, and Provost, Institute for Palliative Medicine at San Diego Hospice.

###

Journal of Palliative Medicine, published monthly in print and online, is an interdisciplinary journal that reports on the clinical, educational, legal, and ethical aspects of care for seriously ill and dying patients. The Journal includes coverage of the latest developments in drug and non-drug treatments for patients with life-threatening diseases including cancer, AIDS, cardiac disease, pulmonary, neurological, and respiratory conditions, and other diseases. The Journal reports on the development of palliative care programs around the United States and the world and on innovations in palliative care education. Tables of content and a sample issue may be viewed online at http://www.liebertpub.com/jpm

Mary Ann Liebert, Inc. is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including AIDS Patient Care and STDs, Population Health Management, and Briefings in Palliative, Hospice, and Pain Medicine & Management, a weekly e-Newsletter. Its biotechnology trade magazine, Genetic Engineering & Biotechnology News (GEN), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 70 journals, newsmagazines, and books is available at http://www.liebertpub.com

Mary Ann Liebert, Inc.
140 Huguenot St., New Rochelle, NY 10801-5215
Phone: 914-740-2100
800-M-LIEBERT
Fax: 914-740-2101
http://www.liebertpub.com


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Opportunities and challenges of palliative care in the ICU discussed in expert roundtable

DNA test for surrogate dad

Hyderabad, Jan. 30: The external affairs ministry has asked an American national to bring her Jamaican husband for a DNA test if she wanted to go ahead with the adoption procedure of her seven-week-old surrogate son born of an Indian mother.

Regional passport officer K. Srikar Reddy said J. Pearl Linda Van Buren Green, a 35-year-old New Yorker, had no "biological connection" with the baby. "She is saying the baby was born by the sperm of her husband. But only a DNA test will confirm that. The father has to come here or, maybe, they can match (the sperm without the father visiting India)," Reddy said.

Green, who claims she had arrived in India with seven samples of her husband's semen, had created a flutter last week when she left her son in the passport complex after being refused an Indian passport for the baby. Police later traced her through a local fertility clinic.

She had apparently declared her son, Emperor Kaioyus Van Buren Green, as an Indian while applying for a passport for the baby. But Reddy said birth on Indian soil could not be a criterion for issuing an Indian passport.

Green could not get a Jamaican passport for the baby as there is no Jamaican embassy either in Hyderabad or in Delhi. She had approached the honorary consul of the Jamaican government in Delhi, but was asked to meet the passport officer in Hyderabad, where her child was conceived in the fertility clinic with eggs donated by a Rajahmundry lady.

Sources in the passport office said the problem in getting a passport would not have arisen had at least one biological parent been an Indian. The absence of the "biological father" ' Eric Dalton Green ' compounded the problem.

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DNA test for surrogate dad

Posted in DNA

Targeted DNA vaccine using an electric pulse

ScienceDaily (Jan. 30, 2012) — The vaccines of the future against infections, influenza and cancer can be administered using an electrical pulse and a specially-produced DNA code from the University of Oslo. The DNA code programs the body's own cells to produce a super-fast missile defence against the disease.

Researchers at the University of Oslo,Norway have developed a new type of DNA vaccine that can be used effectively against viruses and cancer. Studies reveal that the new vaccine triggers a powerful immune response. The vaccine has been tested on mice. Now the researchers hope the vaccine can be tested clinically.

This vaccine has an additional advantage. At the moment, vaccines require the inclusion of immuno-activating substances. These substances are called adjuvants and are generally composed of oil-based mixtures or aluminium salts. Adjuvants initiate local and often painful inflammation at the injection site. This inflammation fools the immune system into reacting to the vaccine.

Without additives

The new vaccine from the University of Oslo does not need the addition of adjuvants. Instead, a completely new technology is used that applies an electrical current to the injection site immediately after injection. This electrical pulse results in a molecular reaction.

"The advantage of this type of reaction is two-fold. Firstly, one injection is enough and, secondly, the immune system reacts very quickly and effectively," points out Professor Bjarne Bogen at the Centre for Immune Regulation at the University of Oslo. Bogen has developed this new vaccine technology together with Professor Inger Sandlie, post-doctorate Agnete B. Fredriksen and a number of other co-workers.

The possibilities with this new vaccine from UiO are numerous. This new vaccine technology means it will be possible to produce vaccines quickly enough to protect against new pandemics, influenza epidemics, or hostile biological threats.

No need to cultivate viruses in eggs

It is time-consuming to make traditional vaccines. Today, in order to make influenza vaccines, viruses have to be cultivated in eggs. It can take almost a year before the vaccine is ready to use.

"The first problem: the world does not have enough eggs to produce influenza vaccine quickly enough for everybody. The second problem: certain forms of the deadly bird flu kill the eggs. Fatality can be as high as 50%. If a new influenza virus kills the eggs, it will not be possible to make a vaccine," explains Bjarne Bogen to the research-magazine Apollon.

His research team is now studying whether it is possible to use this new vaccine technology to develop a rapid and effective vaccine against influenza.

DNA is the solution

The new vaccine is composed of DNA strands. To make a new vaccine, constructing just a section of DNA is enough. Bacteria are good DNA factories. By adding a special substance, the bacteria double the number of DNA strands every 20 mins. This means an 8-fold increase in an hour. Over 24 hours, the bacteria will have produced vast quantities of DNA strands. The DNA strands then need to be cleaned free of the bacteria. This copying method is used by everybody working with DNA.

Programs the cells in the body

The researchers have called the active component in this new vaccine technology Vaccibody.

When DNA is injected together with an electric pulse, DNA is taken up in the skin cells. The cells then read-off the DNA and produce some very special proteins. It is these proteins that are called Vaccibody molecules and to which the immune system reacts so strongly.

This means: the researchers have found the DNA code that programs skin cells in the body to make Vaccibody molecules.

Made up of three parts

The Vaccibody molecules are composed of three components. Each of them has an important role in the immune system. The first component is the target guidance system which, like a pair of gripping pliers, binds to dendrite cells, a type of immune cell discovered by Ralph Steinman, who last year was awarded the Nobel Prize in Medicine.

The second component of the Vaccibody molecules ensures that two identical chains are held together. Tests reveal that this special architecture is highly important if the vaccine is to work.

The third component of the Vaccibody molecule is a small piece of a virus, a bacteria or cancer cell. This small piece is called an antigen.

"The Vaccibody molecules are made so that we can insert all types of antigens. The only condition is that the antigen has a protein structure. We have inserted bits from numerous different viruses and bacteria. All have worked. We have also been able to successfully insert an antigen made up of 523 amino acids. This is an enormous molecule."

The Vaccibody molecules attach to the dendrite cells and are taken to the lymph nodes which are the headquarters of the immune system. There, the dendrite cells "display" the antigen to the most important cells in the immune system, the B cells and T cells.

Not only does this result in large-scale production of B cells, but the immune system is also stimulated to produce aggressive T cells.

"Both of these parts of the immune defence are as a rule important in our protection against viruses and bacteria, and for eliminating cancer cells. This means that Vaccibody offers double protection."

Target guiding gripping pliers

In some types of Vaccibody molecules, the gripping pliers that attach to the dendrite cells are a chemokine. Chemokines are small hormone-like substances that guide the passage of cells through the body.

"We have achieved very good results from our studies with Vaccibody molecules guided using chemokines. The chemokines can be thought of as lighthouses along the coast. They enable the immune cells to navigate correctly and have a special effect on the production of T cells, an attribute that is very important in fighting viruses and cancer," underscores Bogen.

Successful test

The Vaccibody vaccine has so far been tested on mice with cancer and influenza. Eighty percent of the vaccinated mice became resistant to cancer. 100% of those vaccinated were protected against flu. The protection was effective very quickly. Bjarne Bogen hopes that a number of major companies can test the vaccine clinically on people.

Post-doctorate Ranveig Braathen is now developing the second generation Vaccibody where, with the help of molecular cloning, she is testing new variants of the gripping pliers to optimise its efficiency.

Post-doctorate Even Fossum is looking at how Vaccibody can be used to improve the vaccine against tuberculosis. In spite of today's vaccine against tuberculosis, 1.5 million people die every year of this disease. The new vaccine will ensure a much improved immune response against this feared disease.

Post-doctorate Inger Øynebråten is applying Vaccibody technology in the hope of making a vaccine against HIV. PhD students Gunnveig Grødeland, Marta Baranowska and Ane Marie Andersson are using Vaccibody to develop new vaccines against influenza.

Post-doctorate Agnete Brunsvik and PhD student Heidi Spång are using the technology to develop a cancer vaccine for patients with bone marrow cancer and melanoma.

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The above story is reprinted from materials provided by University of Oslo, via AlphaGalileo.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

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Targeted DNA vaccine using an electric pulse

Posted in DNA

DNA Leads To Arrest in 2001 Kidnapping, Sexual Assault

Related To Story


POSTED: 3:09 pm MST January 30, 2012

UPDATED: 4:07 pm MST January 30, 2012

COLORADO SPRINGS, Colo. -- DNA has led to the arrest of a man wanted in the kidnapping and sexual assault of a teenage girl more than a decade ago.On August 20, 2001, a 14-year-old girl walking near Delta Drive and S. Chelton Road in Colorado Springs told police a man offered her a ride, took her to an isolated area, threatened her with a knife, then sexually assaulted her.The teen told police she got away when another car drove into the area. The girl said she got the people in that car to give her a ride. DNA was collected from the victim at a hospital, police said.Ten years later, in September 2011, the Colorado Bureau of Investigation got a match on the suspect DNA submitted to CBI in 2001, according to police.Police said more samples were taken from the suspect in November.Monday, the tests confirmed Gerardo Garcia Cruz as the suspect in the kidnapping and sexual assault, according to Colorado Springs Police.Cruz was arrested on suspicion of kidnapping and sexual assault on a child, police said. The following are comments from our users. Opinions expressed are neither created nor endorsed by TheDenverChannel.com. By posting a comment you agree to accept our Terms of Use. Comments are moderated by the community. To report an offensive or otherwise inappropriate comment, click the "Flag" link that appears beneath that comment. Comments that are flagged by a set number of users will be automatically removed.

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DNA Leads To Arrest in 2001 Kidnapping, Sexual Assault

Posted in DNA

DNA on handgun matched Zvolensky, expert testifies

HAMILTON — Ron Cyr was spotted kissing his mistress in a parked vehicle just one day after his murdered wife’s funeral, jurors were told Monday.

Det.-Const. Michael Tonin, a member of a police surveillance team, said the couple embraced for more than a minute during a mid-afternoon meeting in an empty parking lot.

“It was a passionate kiss, like lovers, people in a relationship,” he testified.

Nadia Gehl, 28, was shot twice and killed while walking to a bus stop on Feb. 2, 2009 near her Watercress Court house in suburban Kitchener.

Cyr, now 33, had moved out of their home and was living with her parents when Gehl — a toy store manager and part-time veterinary technician — was laid to rest exactly a week later.

The afternoon of the next day, Tonin said, Cyr and Michelle Brown — a student at the Gehl family law firm, where Cyr also worked — met for more than half an hour in his black Jeep.

He testified they appeared to be laughing, talking and looking at a piece of paper, although he also saw Cyr wipes his eyes as if crying at one point.

The meeting took place in the parking lot of the National Sports store on Weber Street in Waterloo, a short distance from the Gehl law office.

Tonin said he then saw Brown walking in the direction of the office. Cyr was seen a short time later at the Gehl family home in Kitchener.

Initially unknown to police while Cyr was being watched early in the investigation, Tonin testified, Brown later became a “person of interest” and a target of surveillance herself.

A legal assistant for Gehl’s uncle, criminal defence lawyer Steve Gehl, Cyr is accused of hiring two longtime friends to kill his wife while he had an alibi at work.

He and his alleged accomplices — Dennis Zvolensky, 27, and Nashat Qahwash, 26 — have pleaded not guilty to first-degree murder in Superior Court in Hamilton.

Jurors also heard Monday from two forensic scientists about DNA found on a handgun and tests that were done that led police to conclude it was the murder weapon.

The old Mauser pistol — likely made in Germany sometime between 1914 and 1934 — was found by police hidden above the basement ceiling of a Kitchener house where Qahwash lived with his parents.

By then, the three suspects had been arrested following a six-month investigation that included an undercover officer who allegedly befriended Cyr while posing as a co-worker at a Kitchener furniture store.

Trevor Claxton, a scientist at the Centre of Forensic Sciences, examined the semi-automatic handgun for blood and other bodily substances.

He testified a sample of DNA — which he described as the “chemical blueprint for life” — was found on its grip or handle.

Claxton said tests showed four of nine key locations on a DNA profile matched those of a sample obtained from Zvolensky.

The probability of a random match, he told jurors, was conservatively calculated at one in 400,000. That means just one in 400,000 people in Ontario would be expected to have the same DNA profile in those four locations.

Under cross-examination by defence lawyer Delmar Doucette, who represents Zvolensky, Claxton said there is no way to determine when the DNA linked to his client was left on the gun.

He also testified there were traces of DNA on the gun from at least one other person, although it wasn’t sufficient to develop a profile or do further tests.

Claxton said that people can handle objects without leaving any DNA and that, although unlikely, a person’s DNA can be left on an object without that person actually touching it.

He agreed with Doucette that an indirect transfer of DNA could happen, for example, if someone shook hands with a person who then handled the item in question.

Judy Chin, also a scientist at the Toronto centre, testified that two bullets and three cartridge casings found at the murder scene were all fired by the hidden handgun.

“Very sure,” she answered when asked by Crown prosecutor Julia Forward about the strength of her conclusion.

Chin explained that imperfections and a spiral pattern in gun barrels leave distinct scratch marks on the projectiles fired from them.

“No two (guns) will leave the same marks,” she said.

Chin also did tests to determine how far away the handgun was when Gehl was shot in the left chest and left temple.

Based on patterns left — or not left — by gun powder and other residue, she estimated the fatal head shot was from between three and 28 inches away. The chest shot — which another expert has said came first — was at a distance of more than 15 inches.

Two bullets were found in Gehl’s clothing, one in her bra and the other in her pink tuque, which sported ear flaps and the whimsical profile of an animal on its front.

Since three cartridge casings were found by police, Chin said that likely means one of the shots fired by her killer missed.

An intense affair between Cyr and Brown, and more than $500,000 in life insurance on Gehl, have been raised by Crown prosecutors as possible motives for the Monday morning murder.

Now into its third week, the trial is expected to continue Tuesday with more evidence from surveillance officers.

bcaldwell@therecord.com

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DNA on handgun matched Zvolensky, expert testifies

Posted in DNA

Murder accused DNA 'found in car'

30 January 2012 Last updated at 07:19 ET

DNA from one of the men accused of murdering Constable Stephen Carroll was found in the alleged getaway car, a court has heard.

Brendan McConville, 40, from Aldervale, Tullygally and John Paul Wootton, 20, of Collindale, Lurgan, deny murder.

Constable Carroll was murdered in March 2009.

A forensic expert said DNA on the cuffs and collar of Mr McConville's jacket had a one in a billion chance of belonging to someone else.

The scientist said she uncovered Mr McConville's DNA profile on three separate sites on a brown jacket found in the boot of Mr Wootton's car.

Despite Mr McConville's protestations that he did not own the jacket, Faye Southam said that in her opinion "the findings are more likely to be obtained if he was the regular wearer of the jacket".

Constable Carroll, 48, was shot in the head after answering a 999 call with colleagues.

At the time the dissident republican group, the Continuity IRA, claimed they were responsible for the shooting.

Constable Carroll was the first police officer to be killed since the formation of the Police Service of Northern Ireland (PSNI).

He was a married man with children and from the Banbridge area of County Down. He had served in the police force for more than 24 years.

Mr Wootton's 39-year-old mother Sharon denies perverting the course of justice by removing a computer from her home following the shooting.

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Murder accused DNA 'found in car'

Posted in DNA

FASEB SRC announces conference registration open for: Biology of the Immune System

Public release date: 30-Jan-2012
[ | E-mail | Share ]

Contact: Jessica Lyons
SRC@faseb.org
301-634-7010
Federation of American Societies for Experimental Biology

Bethesda, MD ? The Federation of American Societies for Experimental Biology (FASEB) announces the opening of registration for the Science Research Conference (SRC): Biology of the Immune System.

This conference will take place June24-29, 2012 in Snowmass, Colorado. The conference will bring key leaders and participants together in a small meeting format to discuss emerging areas of interest in Immunology. The nine major sessions will broadly cover the discipline and focus on areas that are currently under intense investigation. Participants stay in a secluded resort and share meals for the length of the conference, creating an atmosphere conducive to in depth discussions and collaborations. Together, the content and format of this meeting will provide participants with cutting edge knowledge about the immune system and the opportunity to interact with leaders in the field.

###

Since 1982, FASEB SRC has offered a continuing series of inter-disciplinary exchanges that are recognized as a valuable complement to the highly successful society meetings. Divided into small groups, scientists from around the world meet intimately and without distractions to explore new approaches to those research areas undergoing rapid scientific changes.

In recent years, the SRC series has expanded into non-summer months. To better enhance the SRC series and allow for future expansion of conferences, FASEB's Office of Scientific Meetings and Conferences recently changed the SRC name from Summer Research Conferences to Science Research Conferences.

FASEB SRC has announced a total of 36 SRCs in 2012, spanning from June through October. To register for an SRC, view preliminary programs, or find a listing of all our 2012 SRCs, please visit http://www.faseb.org/SRC.

Additionally, in efforts to continue expanding the SRC series, potential organizers are encouraged to contact SRC staff at SRC@faseb.org. Proposal guidelines can be found by clicking "Submit a Proposal" on our website at http://www.faseb.org/SRC.

FASEB is composed of 26 societies with more than 100,000 members, making it the largest coalition of biomedical research associations in the United States. Celebrating 100 Years of Advancing the Life Sciences in 2012, FASEB is rededicating its efforts to advance health and well-being by promoting progress and education in biological and biomedical sciences through service to our member societies and collaborative advocacy.


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Continued here:
FASEB SRC announces conference registration open for: Biology of the Immune System

FASEB SRC announces conference registration open for: Liver Biology: Fundamental Mechanisms & Translational Applications

Public release date: 30-Jan-2012
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Contact: Jessica Lyons
SRC@faseb.org
301-634-7010
Federation of American Societies for Experimental Biology

Bethesda, MD ? The Federation of American Societies for Experimental Biology (FASEB) announces the opening of registration for the Science Research Conference (SRC): Liver Biology: Fundamental Mechanisms & Translational Applications.

This conference will take place July 29-August 3, 2012 in Snowmass, Colorado. It is the premier international conference on basic and translational research in liver biology. The goal of the conference is to broaden the attendees' understanding of liver biology in order to advance treatment and diagnosis of liver diseases. Specific session topics will cover liver differentiation metabolism, angiogenesis, injury and hepatic fibrosis, cancer, stem cells and tissue engineering. The program will include presentations from invited speakers and will also include short talks be chosen from submitted abstracts with preference given to junior and early stage investigators. The program will also include two poster sessions and a newly added "meet-the-experts session geared towards providing younger investigators with additional opportunities to network with senior investigators in the field.

###

Since 1982, FASEB SRC has offered a continuing series of inter-disciplinary exchanges that are recognized as a valuable complement to the highly successful society meetings. Divided into small groups, scientists from around the world meet intimately and without distractions to explore new approaches to those research areas undergoing rapid scientific changes.

In recent years, the SRC series has expanded into non-summer months. To better enhance the SRC series and allow for future expansion of conferences, FASEB's Office of Scientific Meetings and Conferences recently changed the SRC name from Summer Research Conferences to Science Research Conferences.

FASEB SRC has announced a total of 36 SRCs in 2012, spanning from June through October. To register for an SRC, view preliminary programs, or find a listing of all our 2012 SRCs, please visit http://www.faseb.org/SRC.

Additionally, in efforts to continue expanding the SRC series, potential organizers are encouraged to contact SRC staff at SRC@faseb.org. Proposal guidelines can be found by clicking "Submit a Proposal" on our website at http://www.faseb.org/SRC.

FASEB is composed of 26 societies with more than 100,000 members, making it the largest coalition of biomedical research associations in the United States. Celebrating 100 Years of Advancing the Life Sciences in 2012, FASEB is rededicating its efforts to advance health and well-being by promoting progress and education in biological and biomedical sciences through service to our member societies and collaborative advocacy.


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FASEB SRC announces conference registration open for: Liver Biology: Fundamental Mechanisms & Translational Applications

FASEB SRC announces conference registration open for: Ubiquitin and Cellular Regulation

Public release date: 30-Jan-2012
[ | E-mail | Share ]

Contact: Robin Crawford
SRC@faseb.org
301-634-7010
Federation of American Societies for Experimental Biology

Bethesda, MD ? The Federation of American Societies for Experimental Biology (FASEB) announces the opening of registration for the Science Research Conference (SRC): Ubiquitin & Cellular Regulation.

This conference will take place June 24-29, 2012 in Saxtons River, Vermont. is the premier forum for the field on the fundamental biochemistry and biologic functions of the ubiquitin-proteasome system. The ubiquitin-proteasome system and ubiquitin-like proteins (Ubls) are key to regulation of virtually all aspects of eukaryotic cell biology.

This conference will highlight advances in our understanding of biochemical mechanisms of ubiquitin and Ubl conjugation, deconjugation, and proteasome function, as well as the role of ubiquitin and Ubls in a broad range of biological contexts, including membrane dynamics, the response to pathogens, human disease, and plant biology.

###

Since 1982, FASEB SRC has offered a continuing series of inter-disciplinary exchanges that are recognized as a valuable complement to the highly successful society meetings. Divided into small groups, scientists from around the world meet intimately and without distractions to explore new approaches to those research areas undergoing rapid scientific changes.

In recent years, the SRC series has expanded into non-summer months. To better enhance the SRC series and allow for future expansion of conferences, FASEB's Office of Scientific Meetings and Conferences recently changed the SRC name from Summer Research Conferences to Science Research Conferences.

FASEB SRC has announced a total of 36 SRCs in 2012, spanning from June through October. To register for an SRC, view preliminary programs, or find a listing of all our 2012 SRCs, please visit http://www.faseb.org/SRC.

Additionally, in efforts to continue expanding the SRC series, potential organizers are encouraged to contact SRC staff at SRC@faseb.org. Proposal guidelines can be found by clicking "Submit a Proposal" on our website at http://www.faseb.org/SRC.

FASEB is composed of 26 societies with more than 100,000 members, making it the largest coalition of biomedical research associations in the United States. Celebrating 100 Years of Advancing the Life Sciences in 2012, FASEB is rededicating its efforts to advance health and well-being by promoting progress and education in biological and biomedical sciences through service to our member societies and collaborative advocacy.


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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

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FASEB SRC announces conference registration open for: Ubiquitin and Cellular Regulation

FASEB SRC announces conference registration open for: Protein Phosphatases

Public release date: 30-Jan-2012
[ | E-mail | Share ]

Contact: Jessica Lyons
SRC@faseb.org
301-634-7010
Federation of American Societies for Experimental Biology

Bethesda, MD ? The Federation of American Societies for Experimental Biology (FASEB) announces the opening of registration for the Science Research Conference (SRC): Protein Phosphatases.

This conference will take place July 15-20, 2012 in Snowmass, Colorado. It provides a forum, where researchers interested in and working on protein phosphatase can meet and discuss their unpublished data, exchange ideas and hypotheses, report about new technologies and intensify and start new collaborations. This 12th biennial conference will include keynote presentations from Drs Jack Dixon and David Sabatini, and sessions on cancer, metabolic disorders, developmental abnormalities, structure, function, regulation, signaling mechanisms, new frontiers and enabling thechnologies, and chemical biology and therapeutics. These sessions will also include short talks selected from submitted abstracts. The goal is to promote the development of fundamental areas of protein phosphatase biology and ultimately facilitate progress towards new therapies for human diseases.

###

Since 1982, FASEB SRC has offered a continuing series of inter-disciplinary exchanges that are recognized as a valuable complement to the highly successful society meetings. Divided into small groups, scientists from around the world meet intimately and without distractions to explore new approaches to those research areas undergoing rapid scientific changes.

In recent years, the SRC series has expanded into non-summer months. To better enhance the SRC series and allow for future expansion of conferences, FASEB's Office of Scientific Meetings and Conferences recently changed the SRC name from Summer Research Conferences to Science Research Conferences.

FASEB SRC has announced a total of 36 SRCs in 2012, spanning from June through October. To register for an SRC, view preliminary programs, or find a listing of all our 2012 SRCs, please visit http://www.faseb.org/SRC.

Additionally, in efforts to continue expanding the SRC series, potential organizers are encouraged to contact SRC staff at SRC@faseb.org. Proposal guidelines can be found by clicking "Submit a Proposal" on our website at http://www.faseb.org/SRC.

FASEB is composed of 26 societies with more than 100,000 members, making it the largest coalition of biomedical research associations in the United States. Celebrating 100 Years of Advancing the Life Sciences in 2012, FASEB is rededicating its efforts to advance health and well-being by promoting progress and education in biological and biomedical sciences through service to our member societies and collaborative advocacy.


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FASEB SRC announces conference registration open for: Protein Phosphatases

‘Anti-aging scarves’ and other talismans for the year of the Dragon

JAMBALAWatch with mantra to protect you from losing wealth

Feng shui specialist Maritess Allen walked into Manila Hotel’s Mabuhay Palace restaurant in a beaded honeysuckle-pink long gown toting a matching Hèrmes Birkin. Pink, she said, is one of the lucky colors for 2012.

Her long hair was set in flirty waves with reddish-copper highlights for good luck (orange and red are the other lucky colors). She rattled off her predictions, and assured us that the world will not end by Dec. 21, as indicated in the Mayan calendar.

“Does anyone here believe that?” she asked, laughing. She suggested that instead of worrying about Armageddon, people should be busy getting married—or making babies.

DRAGON Bangle “activates” the Dragon year.

The year of the Water Dragon is a very auspicious year to tie the knot, and kids born this year are considered lucky. It would take a 12-year cycle before the next Dragon year, so couples have a few months to beat the deadline for having a dragon baby (Chinese New Year in 2013 falls on Feb. 10).

POPULARITY Scarf

Allen, a Filipino, got into feng shui, or the ancient Chinese practice of “balancing energies,” because of a slew of bad luck—in her career, finances, personal life. Feng shui helped her gain luck. She eventually remarried and established World of Feng Shui, an amulet shop based in malls.

She is the go-to geomancer of businessmen like Washington Sycip and Regal Films’ Lily Monteverde; celebrities Kris Aquino and Boy Abunda; and Inquirer columnist and interior designer Tessa Prieto Valdes.

She has trained in Malaysia, Singapore, Thailand, Hong Kong and China on feng shui practices, and has a business degree from Ateneo Professional School.

Allen recently held talks in Manila Hotel and Shangri-La Cineplex and gave guidelines for 2012.

More sex scandals

WINDHORSE Scarf for power

Allen said 2012 is a “transformative year.” It will be more peaceful, with less violence and armed conflicts. Business is competitive and demanding, and it is a good year for real estate.

The Dragon Year has the “external romance flower star,” so there will be a lot of infidelity energy; those born in the year of the Dog must be extra careful. Marriages will be challenged by affairs and sex scandals.

Businesses with wood element will do best, such as plantations, agriculture, publishing and those involving flowers and plants. It is also a good year for earth industries like real estate and construction. Those with  water elements should be extra careful, like baking, shipping, transportation, fishing, alcohol and beverages.

RISING Blue Dragon

Metal industries will have average growth—jewelry, computers, airlines. Fire industries will have a smooth year, like the stock market, entertainment, lighting, food and restaurants, but be wary of investments made by the third quarter.

There is a lack of creativity chi (energy) in career and education: “Promotion is possible but competition is fierce.” Students must stay extra focused.

Health-wise, she advises to take extra care of the waist, ears, kidneys. Patriarchs, especially, need protection from physical harm.

Allen gave an overview for each animal sign: The Rat must “focus on mentally challenging activities than socializing.” The Ox may experience “a tougher year than 2011, but if things go well, it will be very well.” The Tiger will “experience a favorable year, but must choose auspicious months for important dates.”

8 SHAPE Fountain for wealth and money luck

It is a good year for the Rabbits; health, personal and professional relationships will be sound. Ironically, it is not a year for major changes for the Dragons and “obstacles and aggravations are likely.”

“Unique opportunities” will come for the Snake, although “things may not be as easy as last year.” Victory luck will accompany the Horse, and it will be a “fabulous year with fresh opportunities.”

The Sheep will have “plenty of success and achievements, but must control temper” and “relationships may suffer with the ‘quarrelsome star.’”  The Monkey, with an “impressive personal chi, will have wealth and success luck.” Roosters will have “a relatively smoother and trouble-free year.”

BEJEWELED Blue Dragon for power, wealth and success

Dogs must be careful because of the presence of “harmful stars”; timing should be right for major activities. The Boars will have success luck, but should be wary of robbery and betrayal.

Amulets

Abunda recently hosted the full-house Feng Shui Convention in Shangri-La Cineplex, Mandaluyong. He has been consulting with Allen for years, and attested to the power of feng shui which helped him gain show-biz success; he carries several amulets in his bag.

“The items make me feel good, but I make sure it is not in conflict with my faith. I put stuff around the house, but I am not consumed by it,” he said. “There is a certain lightness in carrying feng shui items.”

During the interview in Manila Hotel, Allen showed us her “pet,” a jewel-encrusted dragon ring the color of jade. It is one of her recommended Dragon year “activators,” along with the dragon bangle.

BEJEWELED Dragon with Crystal Globe for good fortune luck

She suggests cures for the signs that need protection from bad luck, such as figurines, jewelry, plaques. Among them: the 5-Element Pagoda with Tree of Life to avoid misfortunes; Medicine Buddha Script Pendant to keep illnesses at bay; and the Anti-Burglary Plaque.

There are also “enhancers” for more luck: the Evil Eye Amulet to guard from jealous colleagues, Wish-Fulfilling Shawl, Flower of Romance Keychain, wealth wallets, auspicious watches, and even an anti-aging scarf for a youthful aura!

MARITESS Allen and Tessa Prieto Valdes

For the home, she suggested putting a water element, like the Eight-Shape Fountain in the Southwest direction for wealth luck; Double Dragon Fountain for career and money luck; and the Rhino and Elephant Fountain to control robbery and violence.

Other dragon items from her shop are the Bejeweled Blue Dragon figurine for power, wealth and success; Dragon with Crystal Globe for good fortune; and Rising Blue Dragon, to be placed in a water pond.

Allen reminded that feng shui is just a guide and is not solely responsible for a person’s future. Also, the items should be bought by the person who would use them, and not given as a gift as you wouldn’t know “from where the money used to buy the item was sourced.” It is also best to retire the amulets used in the previous years because they already served a purpose. These could be kept in a specific case, or buried.

The Chinese New Year countdown with Maritess Allen and the Grand Chinese New Year bazaar will be on Jan. 22-23 in the Tent City of Manila Hotel.

Visit http://www.maritesallen.com

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‘Anti-aging scarves’ and other talismans for the year of the Dragon

Anatomy of a Silver Legend: Hecla's Greens Creek Mine

Over the past year, I have tracked for my readers a series of headaches suffered by legendary silver producer Hecla Mining (NYSE: HL  ) , culminating in Hecla's Hangover: the temporary closure of the Lucky Friday mine in Idaho to allow removal of accumulated debris from its primary silver shaft.

As I headed to Vancouver, British Columbia, last week to attend the Cambridge House World Resource Investment Conference, I was eager to sit down with Hecla CEO Phillips Baker Jr.; not to rehash the events that have precipitated a painful decline in the shares, but rather to refocus investor attention upon the unaltered long-term investment outlook for this 120-year-old icon of the silver industry.

In the forthcoming series of articles, featuring memorable excerpts from my conversation with Mr. Baker, I will present the anatomy of a silver company that I consider just as poised to profitably mine silver for the next 120 years as it has been to date. To catch each of these installments and a wealth of exclusive coverage from the recent conference in Vancouver, please follow me on Twitter or bookmark my article list here.

Greens Creek: Hecla's powerful and reliable cash-flow engine
Christopher Barker: Just as it takes a long-term view to comprehend Hecla's lengthy history, I am far more interested in focusing upon the long-term future of this company than the roughly one-year stoppage at Lucky Friday. Let's begin by discussing the strategic importance of Hecla's Greens Creek mine in Alaska, and how fortunate the company is to be able to target 7 million ounces of silver production from this one mine alone in 2012.

Phillips Baker Jr.: And it's very low-cost silver production. We're not yet releasing our cost estimate for 2012, but clearly over the last 20 years Greens Creek has been one of the lowest-cost silver mines in the world ... consistently. And it will continue to be that. So our margins on those silver ounces are not too far from whatever the price of silver might be.

Barker: Where does Greens Creek fit within the pantheon of the world's great silver mines?

Baker: In the world, Greens Creek is among the 10 largest silver mines, and in the United States it is certainly the largest silver mine. And it's a mine that has consistently replaced reserves. Usually it's every two or three years, you'll see a little decline in the reserves, and then you'll see it gap-up as exploration develops. The mine was put into production in 1989 with a seven-year mine life, so it's remarkable the success we've had with exploration. We currently have about eight or nine years ahead of us in mine life. I would expect that over the next three or four years -- as I look at the reserve / resource base that we have, and where we're going -- that in that period of time we'll have another eight or nine years in front of us.

So it is the underlying cash-flow engine of the company that drives the business. It was an asset that we acquired -- the 70% that we didn't already own -- in 2008. Rio Tinto (NYSE: RIO  ) had been the operator of the mine for almost 20 years before that. When we acquired it, we were convinced of a few of things. One is that it was a high-quality asset that would continue to operate consistent with what it had done in the past. Second, that there was lots of exploration potential. And third, that we wanted to have exposure to the metal price. When you put those things together, you have an asset that really drives the total valuation of the company.

Understanding the long-term productive potential of the Greens Creek district
The ultimate scale of the world's greatest precious-metal deposits is seldom understood in advance of production. The fact that Greens Creek commenced in 1989 with a seven-year mine life offers a fantastic case in point, since the current projected mine life some 22 years later remains a bit longer still. Goldcorp's (NYSE: GG  ) world-class Penasquito gold and silver mine offers another poignant example, where silver reserves have swelled by a remarkable 92% during the five-year period since Silver Wheaton (NYSE: SLW  ) inked its game-changing silver stream agreement for 25% of the Penasquito's life-of-mine production. At full production, it's worth noting, Silver Wheaton's annual take from that watershed silver stream will reach the same 7-million-ounce mark that Hecla is targeting from Greens Creek in 2012. And with a trailing cost of silver production of negative $2.04 (net of by-product credits) through the first nine months of 2011, Hecla's cash margins are even fatter than those resulting from Silver Wheaton's famously profitable cost structure.

Simply stated, the opportunities for organic resource expansion at Hecla's Greens Creek must be understood on two separate axes. On the one hand, the orebody that hosts the current mining operation continues to exhibit strong potential to expand (as Baker discussed above) and periodically extend the mine life. Entirely separate from those on-site exploration efforts, however, Hecla sees potential for the expansive Greens Creek district to host multiple orebodies like the one in production today. It is precisely this sort of potential for discovery of entirely new and legendary orebodies from within the company's delicious portfolio of landholdings that I believe the market has most egregiously overlooked in assigning only about a $1.25 billion enterprise value to the shares. The stock is dirt cheap in relation to its existing portfolio of reserves and resources, with a per-ounce multiple (using silver-only proven and probable reserves plus measured and indicated resources) that is 63% lower than the corresponding resource valuation for rival First Majestic Silver (NYSE: AG  ) ! We'll revisit this point when we dive into the valuation case for Hecla's shares in a forthcoming discussion. For now, I'll let CEO Phillips Baker draw your attention to the potential for brand-new discoveries at Greens Creek, which offers a further bonus beyond the bargain valuation of existing silver reserves and resources.

Baker: Greens Creek has grown into a 27-square-mile land package. The largest piece was subject to a dispute with the federal government that started in the mid-1970s and did not get resolved until 1998 by an act of Congress. And so throughout that time, there was no meaningful exploration work conducted other than within the patented mining claims that were not subject to this dispute. So there is a good example of where we didn't focus on it, and Rio didn't focus on it, because it didn't make any sense until the early 2000s.

Geologically, Greens Creek was formed through what is called a "black smoker." Think of it like a little volcano -- not unlike the Hawaiian Islands -- where you have that hotspot and the Earth's crust moves over it over time. Well in this case, the hotspot is frequently spewing out sulphides, so that's what we're looking for. These types of orebodies typically come in a cluster. So that's what we're looking for.

Barker: And the deposit that you're mining right now, that's conceivably just one of those? One of those mineralizing events, basically?

Baker: Right. Correct. And to put that into context, that mine has produced 200 million ounces of silver over the last 22 years, and produced more than 1.2 million ounces of gold,
and I couldn't tell you how much lead and zinc. So that's what we're looking for is another one of those with this surface exploration program that we have ongoing.

Now, understand, this is a bit like finding a needle in a haystack. And you're limited to exploring only in the summers. It is very rugged country. And so to get a half-dozen or a dozen holes in during a summer, that's about all you are able to do. But when you have success, you'll go in to follow up, and you'll hit it pretty hard.

So when I look at Greens Creek, this is an example of a district that -- despite how prolific it's been since being discovered by Noranda in 1973 (and subject to the dispute until 1998), and given the poor prices until 2004 -- it's only been in the last seven years that meaningful work has been done, and only then during the summers. So we're in the early stages of this thing despite the 22 years that it's been in production.

Looking for more ideas? Download The Motley Fool's special free report "The Tiny Gold Stock Digging Up Massive Profits." Our analysts have uncovered a little-known gold miner that we believe is poised for greatness; find out which company it is and why we strongly believe in its future -- for free!

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Anatomy of a Silver Legend: Hecla's Greens Creek Mine

Anatomy of a state-owned bank

Mr Hester succeeded Sir Fred Goodwin (known as Fred the Shred because of his cost-cutting reputation) in November 2008.

At the time, RBS was in turmoil, having to be bailed out by the taxpayer to the tune of £45bn. For a short time, the bank had even been the biggest bank in the world. This £45bn "investment" is worth just £25bn today and the bank's share price has tumbled from 180p, before Mr Hester was appointed, to 27p today.

This is not good news for shareholders, especially the taxpayer, who owns 82 per cent of the company.

In the dark days of 2008, RBS made a staggering £24bn loss, the biggest in British corporate history. Since then, losses have been stemmed (to £1.1bn in 2010 and £3.6bn in 2009) and in the first nine months of 2011, the bank made a modest £1.2bn profit.

Mr Hester's priority has been to shrink RBS, which had become so swollen before the bailout that it was deemed "too big to fail". He has succeeded in doing this, reducing the firm's balance sheet (made up of assets and liabilities) from £2.2tr to £1.6tr, a reduction of £600bn.

But RBS is still a huge business - bigger than the £1.4tr size of the British economy. This is despite the loss of 33,000 staff, who have been axed since he took over.

Mr Hester is paid £1.2m a year, and was entitled to a short-term bonus of £963,000. At RBS, there is a cap on short-term bonuses of 200 per cent of salary - £2.4m in Mr Hester's case. He is also in line for long-term bonuses of as much as £8m.

RBS argues that he is worth it because he has made the company safer and turned it into a profit-making business.

Bonus busted: RBS chief Stephen Hester waives bonus

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Anatomy of a state-owned bank

Stem cell treatment for animals – Video

26-01-2012 02:37 Animacel ltd. is offering your animal stem cell treatment with newly developed stem cell therapy. At the moment, excellent results are with treatments of different joint problems (arthritis and injury/damage of cartilage, hip dysplasia), tendon problems and supporting/adjuvant stem cell therapy for faster healing of broken bones. We are also developing treatment for heart insufficiency, eye dissease, diabetes, etc. See our webpage http://www.animacel.com

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Stem cell treatment for animals - Video

Homeschool students learn science in unique fashion

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MECKLENBURG COUNTY, N.C. — An increasingly popular biology
course at a North Carolina nature center is providing a
classroom-style learning experience for home school students.

The unique science lab is becoming in high-demand for students.

Using clay, a group of homeschoolers gets a lesson in science.
They mold the stages of a bullfrog's lifecycle and learn a
biology in the process.


“I didn't know a lot about homeschooling before this job. I
just thought they stayed at home and learned and never really
got out. And I think that's the perception of it,” said
Anne-Marie Stevenson with the Latta Plantation Nature Center.

Stevenson teaches the homeschool biology course for
third-graders through fifth-graders at Latta Nature Center.
High demand for the class pushed the center to open a second
course so students could get the lab experience that Stevenson
said is vital.

“They're learning how to cooperate and divide tasks up and work
together,” said Stevenson.

Homeschool student Sudie St. Yves took part in the project a
couple of years ago.

“We had to feed [the tadpole] lettuce and flightless fruit
flies and pretty much we're going to have to do the same
thing,” said St. Yves.

Stevenson hopes the classroom-style environment will help the
homeschool students start to think like scientists

Original post:
Homeschool students learn science in unique fashion

'Grey's Anatomy': 'If/Then' Alternate Reality Sneak Preview (VIDEO)

As Meredith puts Zola to bed and falls asleep, she begins to
wonder -- what if her mother had never had Alzheimer's and
she'd had loving, supportive parents? The reverberations of a
happy Meredith Grey change the world of Seattle Grace as we
know it. What if she had never met Derek in that bar and he had
never separated from Addison? What if Callie and Owen had
become a couple long before she met Arizona? And what if Bailey
never evolved from the meek intern she once was? "Grey's
Anatomy" airs THURSDAY, FEBRUARY 2 (9:00-10:02 p.m., ET) on the
ABC Television Network.

As Meredith puts Zola to bed and falls asleep, she begins to
wonder -- what if her mother had never had Alzheimer's and she'd
had loving, supportive parents? The reverberations of a happy
Meredith Grey change the world of Seattle Grace as we know it.
What if she had never met Derek in that bar and he had never
separated from Addison? What if Callie and Owen had become a
couple long before she met Arizona? And what if Bailey never
evolved from the meek intern she once was? "Grey's Anatomy" airs
THURSDAY, FEBRUARY 2 (9:00-10:02 p.m., ET) on the ABC Television
Network.

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'Grey's Anatomy': 'If/Then' Alternate Reality Sneak Preview (VIDEO)

Metabolic Syndrome May Raise Risk of Peripheral Artery Disease

(HealthDay News) -- Women with metabolic syndrome are at high risk of developing peripheral artery disease, a condition that dramatically raises the risk of heart disease and stroke.

Using data on more than 27,000 women taking part in the Women's Health Study, researchers identified participants with metabolic syndrome, a collection of symptoms including abdominal obesity, high blood pressure, low HDL ("good") cholesterol, high triglyceride levels and insulin resistance.

Women were considered to have metabolic syndrome if they had three or more of those symptoms.

Women with metabolic syndrome had a 62 percent increased risk of developing peripheral artery disease (PAD) compared to those without metabolic syndrome. Each metabolic syndrome symptom raised the risk of PAD by 20 percent, the study found.

About 8 million Americans have peripheral artery disease, which typically affects the arteries in the pelvis and legs. Symptoms include cramping and pain or tiredness in the hip muscles and legs when walking or climbing stairs, although not everyone who has PAD is symptomatic. The pain usually subsides during rest. Read more...

Ayurtox for Body Detoxification

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