Research and Markets: Malaysia Baby Food & Paediatric Nutrition Market: Analysis & Forecast (2007 – 2017)

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DUBLIN--(BUSINESS WIRE)-- Research and Markets(http://www.researchandmarkets.com/research/90cb8b/malaysia_baby_food) has announced the addition of the "Malaysia Baby Food & Paediatric Nutrition Market: Analysis & Forecast (2007 - 2017)" report to their offering.

Parent's desire to give the best to their babies and rising income levels has helped the strong growth in the Malaysian baby food & paediatric nutrition market, despite the declining birth rates. The rising awareness about the baby food benefits and parents' concern over their child's growth will drive the growth of Malaysia baby food & paediatric nutrition market over the forecasted period. The Malaysia baby food and paediatric nutrition sales value expected to grow with a CAGR of 6.58% during 2012 - 2017 to be worth USD 577.8 million in 2017. Danone continues to lead the market with about 1/3rd of the market share in 2011.

This report provides a holistic view to the overall Malaysia Baby Food and Paediatric Nutrition market with over view of Asia - Pacific Market and 11 year market data & forecast based on following segmentation:

By Product

Bottled baby food Baby cereals Baby snacks Baby soups Canned & Frozen baby foods

By Type

Dried Baby Food Milk Formula Prepared Baby Food Other Baby Food

Key Topics Covered:

Chapter 1 Introduction 1.1 Objectives & Coverage 1.2 Report Description 1.3 Scope And Definitions 1.3.1 Segmentation & Analysis 1.4 Stakeholders 1.5 Data Sources, Methodology & Forecasting

Chapter 2 Asia - Pacific Baby Food & Pediatric Nutrition Market 2.1 Overview 2.2 Demographic Trends 2.3 Drivers 2.4 Inhibitors 2.5 Opportunities 2.6 Market Size & Growth 2.7 Market Trend 2.8 Future Prospect 2.9 Market Forecast 2.10 Competitive Landscape

Chapter 3 Malaysia Baby Food & Pediatric Nutrition Market 3.1 Market Size & Growth 3.2 Market Trend 3.3 Future Prospect 3.4 Market Forecast 3.5 Competitive Landscape

For more information visit http://www.researchandmarkets.com/research/90cb8b/malaysia_baby_food

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Research and Markets: Malaysia Baby Food & Paediatric Nutrition Market: Analysis & Forecast (2007 - 2017)

Antaeus Labs & Predator Nutrition Press Release

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BRADFORD, England, February 1, 2012 /PRNewswire/ --

Predator Nutrition is regarded as the first port of call for high quality proteins and other nutritional supplements and sporting accessories in Europe and the UK, with a reputation for collaborating with some of the top sports supplement manufacturers in the world.

Predator Nutrition's latest exclusive distribution deal is with American sports supplements manufacturer, Antaeus Labs.

Antaeus Labs are well known for their discovery, development and distribution of highly effective transdermal delivery systems and innovative legal muscle building supplements. They are at the forefront of pioneering new techniques and products that will continue to transform the sports supplementation world with every new product that they introduce.

They are bestknown for products such as Trenazone and Ultradrol. Trenazoneis a cutting edge transdermal delivery system that promotes muscle growth in an innovative way, and Ultradrol has been labelled as "the world's best legal bulking and repartitioning agent".

With this in mind, and with Predator Nutrition's already sterling reputation for excellent customer service and a huge range of the premium quality supplements, the collaboration between these two companies is sure to benefit both parties and their customers worldwide. This new deal gives Predator Nutrition the exclusive rights to distribute Antaeus Labs' products in Europe and the UK.

The man behind Predator Nutrition, Reggie Johal said that "Antaeus Labs is a company that we have been interested in for years. They are pioneers in the sports supplements world and are dedicated to providing high quality products that we in turn will distribute with high quality service. It really is a pleasure to be collaborating with such a top quality brand."

Antaeus Labs CEO, Jake Ganor, also commented on the deal with encouraging words "we have been working alongside Predator Nutrition for a while now and see this exclusivity deal as a fantastic stepping stone to great things for both of us."

With this recent announcement it is clear that both parties are working hard to creating a bright future for the sports supplements world. With both Antaeus Labs and Predator Nutrition experiencing rapid growth and the announcement of the latest deal, both brands are sure to go from strength to strength in 2012 and beyond.

 

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Antaeus Labs & Predator Nutrition Press Release

Iowa City board approves assessor's budget, eliminates longevity funds

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Iowa City board approves assessor's budget, eliminates longevity funds

BY DI STAFF | FEBRUARY 01, 2012 7:20 AM

The Iowa City Conference Board passed the City Assessor's fiscal-year 2013 budget proposal during one of its two yearly meetings Tuesday night.

The conference board — consisting of Iowa City city councilors, Johnson County supervisors, and Iowa City School Board members — voted to eliminate a proposed $3,525 longevity expenditure before passing the budget. Longevity pay was previously allotted $3,350 for fiscal-year 2012.

City Assessor Dennis Baldridge said the conference board eliminated step/merit pay for fiscal 2012 because they want to spend more time evaluating how the pay options would effect citizens. The proposed step/merit expenditures for fiscal 2013 is $6,000.

Baldridge suggested the conference board leave both longevity and merit/salary pay in the budget for this meeting and vote at the next meeting.

But conference board members insisted on proceeding with only step/merit pay.

"We're either doing longevity or merit," Supervisor Janelle Rettig said. "I think [Baldridge] wanted to move to merit last year, but we didn't have a clear direction from the conference board to do that."

All conference members approved the budget proposal with the elimination of the longevity pay.

The assessor's budget will be effective July 1.

A public hearing for the assessor's budget will be held March 6 at 3 p.m.

—by Kristen East

In today's issue:

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Assessing the value of BMI screening and surveillance in schools

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Public release date: 1-Feb-2012
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Contact: Vicki Cohn
vcohn@liebertpub.com
914-740-2100
Mary Ann Liebert, Inc./Genetic Engineering News

New Rochelle, NY -- The value of routine body mass index (BMI) screening in schools has been a topic of ongoing controversy. An expert Roundtable Discussion in the current issue of Childhood Obesity, a peer-reviewed journal published by Mary Ann Liebert, Inc., debates the pros and cons of routine BMI screening in the school setting, discusses the most recent data, and explores when and for what purpose BMI screening results should be shared with parents and the potential benefits. The Roundtable is available online.

Patricia B. Crawford, DrPH, RD, Adjunct Professor, University of California, Berkeley, moderates the Roundtable entitled, "An Update on the Use and Value of School BMI Screening, Surveillance, and Reporting." Participants include Jim Hinson, PhD, Superintendent of Schools, Independence School District, Missouri, Kristine Madsen, MD, MPH, Assistant Professor, University of California, San Francisco, Dianne Neumark-Sztainer, PhD, MPH, RD, Professor, University of Minnesota, Minneapolis, and Allison Nihiser, MPH, Health Scientist, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia.

"Ignoring this issue is clearly not an option," says David L. Katz, MD, MPH, Editor-in-Chief of Childhood Obesity and Director of Yale University's Prevention Research Center. "But it must be handled thoughtfully so that what we know about BMI in kids empowers us and them, and their parents, and their teachers to do something constructive, and compassionate about it. This insightful, multidisciplinary group highlights the important opportunities in this strategy, while considering how to avoid any potential pitfalls. Great insights here and very practical guidance."

###

Childhood Obesity is a bimonthly peer-reviewed journal, published in print and online, and the journal of record for all aspects of communication on the broad spectrum of issues and strategies related to weight management and obesity prevention in children and adolescents. The Journal includes peer-reviewed articles documenting cutting-edge research and clinical studies, opinion pieces and roundtable discussions, profiles of successful programs and interventions, and updates on task force recommendations, global initiatives, and policy platforms. It reports on news and developments in science and medicine, features programs and initiatives developed in the public and private sector, and includes a Literature Watch and Web Watch. Tables of content and a free sample issue may be viewed online.

Mary Ann Liebert, Inc. is a privately held, fully integrated media company known for establishing authoritative medical and biomedical peer-reviewed journals, including Metabolic Syndrome and Related Disorders, Population Health Management, Diabetes Technology & Therapeutics, and Journal of Women's Health. Its biotechnology trade magazine, Genetic Engineering & Biotechnology News (GEN), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 70 journals, newsmagazines, and books is available on our website.

Mary Ann Liebert, Inc.
140 Huguenot Street,
New Rochelle, NY 10801-5215
http://www.liebertpub.com
Phone 914-740-2100
800-M-LIEBERT
Fax 914-740-2101


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Releasing DNA fear codes,Galactic Federation of Light, Sharon-Ann Riley, 2 February 2012 – Video

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24-01-2012 06:06 Sharon-Ann Riley channels the Galactic Federation of Light. The GFL discuss Cosmic triggers demolishing old mind control programs, slave encodings, family dna karma release. Sharon-Ann Riley is a Galactic Ambassador whose role is to empower humanity to trust its divinity and spiritual knowingness.She has experienced ET visitations and UFO encounters throughout her life. She is an incarnated Galactic Federation Ascended Master and Blue Ray Star Seed. Her role is to prepare Humanity for its galactic re-emergence. Sharon assists the Galactic Federation, Cosmic / multidimensional beings and Mother Gaia with Earth Healing. She is guided to various places around the world to channel energy and activate the land by the Great Mother and Galactic Federation. http://www.sharonannriley.com Email: info@sharonannriley.com Written Transcript: http://www.sharonannriley.com The above transcript is copyrighted to http://www.sharonannriley.com . Posting on websites is permitted as long as the information is not altered and credit to ©2011 Sharon-Ann Riley and website is included. For all publications / syndications please contact info@sharonannriley.com

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Releasing DNA fear codes,Galactic Federation of Light, Sharon-Ann Riley, 2 February 2012 - Video

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Sacred Geometry DNA changes 2012 Mollecular Atom Consciousness.mp4 – Video

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28-01-2012 06:10 uploaded by Killuminatithemovie with clips from the "esoteric agenda" Please visit my channel and Subscribe Izabelab@rocketmail.com Anastasia Beavenhouser on FB. new paradigm 2012 shamanism shift cleansing 2012 mother earth climatic disaster pole shift end time new world new earth hopi prophecy 2012 December Dec 21st 2012 Apocalypse end world Rapture time asteroids Nostradamus native american calentamiento end of world end of the world as we know it end of paradigm new paradigm change Extreme Weather Patterns Maya END OF THE WORLD DOOMS DAY NEW AGE change evoloution shift timewave zero terence mckenna 2012 sightings nostradamus dimensional shift omega dedroidify Mayan Calendar Apocalypse Pinchbeck i ching prophecies prophecy alien ufo illuminati solar radiation Harmonic Convergence Great Shift cosmic cycle Pleiades The Photon belt Great Shift the wave of love red elk Galactic Federation solstice quetzalcoatl Pahana global warming pleiades orion singularity quantum revelations spirituality vision quest Apocalypse Armageddon endtime rapture apocalypto thunderbeing films ken thornton post 2012 emergence planetary ET Pleiadian wayshowers WWIII alycone indigo galactic yoga sacred geometry pineal ufo phi om fifth 5th sun gloabl shift Pleiades bloodline David Icke lightworkers seer photons cosmic arcturian alignment enlightenment 5th dimenson mass awakening great awakening wayshower way shower heyoka light cosmic rays sun ascended indigo children 2012 milky way ken thornton ...

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Posted in DNA

MyTaq DNA Polymerase – Product Overview, Features

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01-02-2012 03:13 Bioline's Senior Global Product Manager, Dr Steve Hawkins, runs through the features, benefits and specially formulated novel buffer system of MyTaq DNA Polymerase. About MyTaq The MyTaq DNA Polymerase product range is a new generation of very high performance PCR products developed by Bioline: The PCR Company, specifically designed to deliver outstanding results on all templates, including complex genomic DNA. MyTaq is based on the latest technology in PCR enzyme preparation, engineered to increase affinity for DNA, resulting in significant improvements to yield, sensitivity and speed. The enzyme is supplied with an industry-leading novel buffer system, specifically formulated and validated for the unique properties of MyTaq, making it the perfect choice for all of your PCR assays. For more information please see: bioline.com

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# 1146 Native Americans DNA Linked to Altai from Russia – Video

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30-01-2012 19:22 Penn Research Finds Genetic Link Between Native Americans, Russian Region Artifacts show that humans were living in North America 15000 years ago; they reached the tip of South America over the next 2000 years. Using techniques akin to DNA fingerprinting, scientists have continued to gather evidence that the majority of current native people of North and South America derive their ancestry from Asia. University of Pennsylvania researcher Theodore Schurr's group focused on two types of DNA - mitochondrial DNA, which is passed down in eggs and traces maternal lines, and the Y chromosome, which is passed down through male lines. The Y chromosome analysis took advantage of non-coding regions, which are not part of genes and which are used in criminal forensics to match suspects to crime scenes. These DNA regions differ from one person to another, Schurr said. The more such quirks people share, the more recently they are likely to have had a common ancestry. Schurr said his group had collected about 1500 DNA samples from Native Americans, as well as 750 from people in the Altai. The researchers also compared DNA from people from other parts of Asia. The scientists can use groups of variations on the Y chromosome to identify specific human male lineages, and variations in mitochondrial DNA to trace female lineages. Male lineages called Q, and a subset of Q called Q-M3, appear widespread in Native Americans and are thought to have come from a founder population. Both also appear ...

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# 1146 Native Americans DNA Linked to Altai from Russia - Video

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Oxford Nanopore to Present DNA 'Strand Sequencing' Technology at AGBT Conference

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OXFORD, England--(BUSINESS WIRE)-- Oxford Nanopore Technologies Ltd. announces that Clive G Brown, Chief Technology Officer, will present at the Advances in Genome Biology and Technology (AGBT) conference in Marco Island, Florida, on 17th February 2012 at 11.40am (EST) / 4.40pm (GMT).

The talk is titled: “Single Molecule ‘Strand’ Sequencing Using Protein Nanopores and Scalable Electronic Devices”.

Oxford Nanopore intends to commercialise DNA strand sequencing products, directly to customers within 2012. At the AGBT presentation, Oxford Nanopore will show DNA strand sequencing data and other disruptive features of the Company's proprietary electronics-based sensing devices.

Further information will be provided at the time of the Company's presentation at the AGBT conference.

-ends-

Notes to editors

Oxford Nanopore Technologies

Oxford Nanopore Technologies Ltd is developing a novel technology for direct, electronic detection and analysis of single molecules using nanopores. The modular, scalable GridION technology platform is designed to offer substantial benefits in a variety of applications.

The Company is developing two techniques for DNA sequencing: Strand Sequencing, and Exonuclease sequencing, both of which combine a protein nanopore with a processive enzyme for the analysis of DNA. The system is also compatible with the direct analysis of RNA. The Company has signed a commercialisation agreement for its exonuclease sequencing technology but not its strand sequencing technology which it intends to commercialise independently. Oxford Nanopore is also developing a Protein Analysis technology that combines target proteins with ligands for direct, electronic analysis using protein nanopores. These nanopore sensing techniques are combined with the Company's proprietary array chip within the GridION system.

The Company is also developing the subsequent generation of nanopore sensing devices based on solid-state nanopores.

Oxford Nanopore has licensed or owns more than 300 patents and patent applications that relate to many aspects of nanopore sensing including fundamental nanopore sensing patents, analysis using protein nanopores or solid state nanopores and for the analysis of DNA, proteins and other molecules. The Company has collaborations and exclusive licensing deals with leading institutions including the University of Oxford, Harvard and UCSC. Oxford Nanopore has funding programmes in these laboratories to support the science of nanopore sensing. This includes the use of functionalised solid-state nanopores for molecular characterisation, methods of fabricating solid-state nanopores and modifications of solid-state nanopores to adjust sensitivity or other parameters.

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Oxford Nanopore to Present DNA 'Strand Sequencing' Technology at AGBT Conference

Posted in DNA

Oxford Nanopore to Market DNA Strand-Sequencing Products Starting in 2012

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Oxford Nanopore Technologies Ltd., the U.K. company developing a novel gene-sequencing technology, plans to market DNA strand-sequencing products directly to customers this year.

Oxford Nanopore will present data on strand sequencing at the Advances in Genome Biology and Technology conference in Florida on Feb. 17, the closely held Oxford, England-based company said today in a statement. IP Group Plc (IPO), which owns 21.5 percent of Oxford Nanopore, rose to its highest price since 2008 in London trading.

The announcement signals that Oxford Nanopore’s more immediate plans are to sell systems that don’t rely on exonuclease sequencing, for which it has a deal with Illumina Inc. (ILMN), the San Diego-based maker of gene-sequencing machines that Roche Holding AG (ROG) is trying to buy.

“With strand you’re reading the DNA directly,” Chief Technology Officer Clive Brown, who is presenting Oxford Nanopore’s data on Feb. 17, said in an interview. “You get more information of more biological utility coming out.”

Illumina owns 15 percent of Oxford Nanopore. Its other shareholders include Lansdowne Partners and Invesco Perpetual, the U.K. group of mutual funds.

$1 Billion Value

Oxford Nanopore is valued at about $1 billion, and IP Group’s holding could add 38 pence a share to its stock, said Charles Weston, a London-based analyst at Numis Securities, which advises IP Group, in a note to investors. He based the figures on Oxford Nanopore gaining 25 percent of a market that could grow to $6 billion within five years.

Weston raised his rating on London-based IP Group to “add” from “hold.” IP Group climbed 14 percent to close at 101 pence, the biggest increase since Aug. 26, 2009. That gives the company a market value of 369.4 million pounds ($586 million).

“It’s obviously a fantastic validation for IP Group, but it now becomes a very large part of their portfolio,” Weston said in an interview.

Oxford Nanopore is entering the race to develop a next- generation machine able to decode the building blocks of life in a single day, Weston said. Among the challenges it faces are competition from much larger companies, the lack of a sales force and that its technology hasn’t subjected to the scrutiny of potential users, he said.

More Funding

The company has raised 74 million pounds since it was founded and will need more funding before marketing its products, Chief Executive Officer Gordon Sanghera said in an interview yesterday. Financing could come from an initial public offering or additional private funding, he said.

“My feeling is we will do another private round,” Sanghera said. “We probably have a shareholder base that says stay put and wait until we have a burgeoning customer base.”

In addition to its major shareholders, Oxford Nanopore has individual shareholders, including company managers, and employees have stock options, according to the company.

Roche on Jan. 25 offered to buy Illumina, which has a majority of the market share for new gene-sequencing equipment, for $5.7 billion in a hostile takeover bid. That came after Illumina said its new HiSeq 2500 machine will be available in the second half of the year.

Illumina’s competitor, Carlsbad, California-based Life Technologies Corp. (LIFE), also said last month it is taking orders for a $149,000 benchtop machine called the Ion Proton Sequencer, which is designed to fully transcribe a person’s DNA in a day, rather than weeks or months, for about $1,000.

Oxford Origin

Oxford Nanopore, spun out of University of Oxford in 2005, uses different sequencing technologies that were initially based on the research of founder and board member Hagan Bayley, a chemistry professor at the university. The company has built on that science through collaborations with researchers at Harvard University, the University of California Santa Cruz and Boston University, among others, and with internal research, said Zoe McDougall, a spokeswoman.

The techniques rely on an engineered protein or nanopore that creates a tiny hole in a cell membrane one-billionth of a meter wide. As DNA bases or building blocks pass through the hole, an electronic chip measures changes in electrical current in the membrane and produces data that, when decoded, identifies the sequence of bases that make up a genome.

In strand sequencing, an entire string of DNA is guided by an enzyme and passes intact through the hole. In exonuclease sequencing, the DNA building blocks are separated by an enzyme and pass individually through the hole.

Strand sequencing provides more genetic information more cheaply, Oxford Nanopore’s Brown said. The technique can read long and complicated DNA structures more easily and with less sample preparation, he said. It also requires less computer software and smaller computers, Brown said.

To contact the reporter on this story: Andrea Gerlin in London at agerlin@bloomberg.net

To contact the editor responsible for this story: Phil Serafino at pserafino@bloomberg.net

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A step closer to understanding, averting drug resistance

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Public release date: 1-Feb-2012
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Contact: Susan Chaityn Lebovits
lebovits@brandies.edu
781-726-4027
Brandeis University

Bacterial resistance to antibiotics is growing exponentially, contributing to an estimated 99,000 deaths from hospital-associated infections in the U.S. annually, according to the Centers for Disease Control and Prevention. One reason that this is happening is that drug resistant proteins are transporting "good" antibiotics, or inhibitors, out of the cells, leaving them to mutate.

In a paper recently published in the journal Nature, Professor of Biochemistry Dorothee Kern and collaborators including former postdoctoral student Katherine A. Henzler-Wildman, looked at how one of these drug transporters, EmrE, works. The hope is that someday a drug will be developed to impede this motion of transport.

"You have a disease and an antibiotic goes into the cells to try to kill it," explains Kern. "But the protein EmrE takes the antibiotic and transports it out. The goal would be to find clever ways to stop EmrE from functioning as an exporter while allowing necessary nutrients to remain"

The challenge with making drugs, says Kern, is that you need to kill specific targets but nothing else.

Kern and her team studied the protein using nuclear magnetic resonance (NMR) spectroscopy, adding a drug mimetic in order to learn how the structure EmrE was designed and how it functioned as it was transporting ? moving the drug from inside of the cell to the outside. Currently there are around 12 to 13 similarly known proteins within the EmrE family.

Increasing the knowledge of how this protein works will hopefully help to target all of them. Once you understand that, you could design inhibitors that do not allow the protein to transport the "good" drugs out.

"We were actually looking at a transporter in real time," says Kern. "That is something very novel as previously these structures were only seen by X-ray crystallography, so they were frozen, and not moving."

Kern says EmrE actually bounces back and forth between two alternate conformations, hand-shaped structures that take one molecule, pump it out, return to grab the next one, then pumps that one out (Fig. 1).

"The cool thing about discovering how the protein functions is that this was unexpected," says Kern. "Everyone thought that the inside and the outside had two different structures."

Kern says that she is extremely proud of her former postdoctoral student, who began working on the project at Brandeis in 2006 and has continued pushing and leading this project at Washington University in St. Louis, where she is now an assistant professor of ?biochemistry and molecular biophysics.

"Before Katie had worked out the kinks, my lab continued to make proteins for her and shipped them there," says Kern. "In collaboration with postdoctoral fellow Michael Clarkson, the NMR dynamics experiments were collected at Brandeis. It's been a real fun collaboration."

Why are there so many resistant strains of bacteria?

Antibiotics try to kill bacteria. To avoid being killed bacteria mutate, meaning that they change the structure of the amino acids within their cell. This way the protein is no longer able to be taken over by the antibiotic.

"These bacteria survive and duplicate every 20 minutes," says Kern. "Now you have a new strain, a new form of bacteria and the designed drug no longer works. This survival and changing of composition occurs when an antibiotic encounters them."

As more antibiotics are being used, more new strains of bacteria are created that are resistant to current antibiotics, which is why bacteria and viruses are harder to target.

"It's called mutagenesis?changes in the genomic material and bacteria can do this very quickly," says Kern. "If you look at the statistics, the numbers of resistant strains are exponentially growing."

Kern cautions against purchasing anti-bacterial products such as cutting boards, soaps and toothpaste as they are contributing to this rash of mutations.

"If you have an infection and use a high concentration of antibiotics, the bacteria are being killed before they can adapt and change,"says Kern. "If the dose is very small, they are not all getting killed, and they have time to mutate."

Kern says this is another reason why it is so crucial to complete a prescribed course of antibiotics when you're sick even if you're asymptomatic ?if 95 percent of the bacteria are gone, there is still five percent that can develop resistance in a matter of days.

###


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The Dog Study that Invalidates Behavioral Science – Video

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04-10-2011 05:56 This 18 year study involving over 1000 dogs and owners lifts the curtain on the dog and human dynamic. Dale McCluskey shows the reasons behind failure within many feel good and owner focused systems of training. Why so many trainers are exploiting conditioning and misrepresenting dominance for the sake of their bridge to no where agenda. This study is from Dale's new book "The Mind and Body Connection - New and Profound Insight into the Dog and Human Dynamic" Available at Barnes and Noble and Amazon Kindle.

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NSABB and H5N1 redactions: Biosecurity runs up against scientific endeavor

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Public release date: 31-Jan-2012
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Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology

In response to recent actions of the U.S. National Science Advisory Board for Biosecurity (NSABB), which recommended that two scientific journals withhold crucial details in upcoming reports about experiments with a novel strain of the bird flu virus, H5N1, the American Society for Microbiology (ASM) will publish a special series of commentaries by prominent scientists, including the acting chair of the NSABB, weighing in on whether the recommendations were necessary and what role biosecurity considerations should play in the dissemination of research findings. The commentaries will be published in the Society's online, open-access journal, mBio?, on January 31. The commentaries are accompanied by an editorial from Editor-in-Chief Arturo Casadevall and ASM Publications Board Chair Thomas Shenk who introduce the problem as the H5N1 manuscript redaction controversy.

The strain of avian flu in question has caused hundreds of deaths worldwide, and though it is highly lethal in humans, it apparently lacks the ability to transmit easily from person to person. The current controversy surrounds a report that describes experiments that created a form of the H5N1 virus that is transmissible from ferret to ferret, animals used as models of human flu infection.

In the interest of biosecurity, the NSABB recommended that the federal government move to restrict information in the study that would enable a reader to replicate the experiments that enhanced the transmissibility of the virus. The government honored the recommendation and asked the scholarly journals in question, Science and Nature, to redact many of the experimental details, an unprecedented request to which the researchers and journals agreed. This recommendation has generated tremendous controversy among scientists. As noted by Drs. Casadevall and Shenk in their accompanying editorial, the controversy poses a new problem for scientists who are used to resolving disputes with additional laboratory work but are now in a position where they cannot use this method of conflict resolution to settle the matter.

In the first Commentary, Paul Keim, the acting chair of the NSABB and the Chair of the Microbiology Department at Northern Arizona University, lays out his reasons for supporting these recommendations. According to Keim, the fact that it is possible for a highly virulent form of the bird flu virus to acquire the ability to transmit from mammal to mammal is the most important piece of information in the study and should compel policy makers, granting agencies, public health officials, vaccine and drug developers to move forward with greater urgency in developing flu-fighting infrastructure. The experimental details, on the other hand, would not enhance public health efforts and could actually enable those with ill intent to create a strain of flu that would put lives in danger.

Robert Webster, of St Jude Children's Research Hospital in Memphis, Tennessee, asks how science and policy can maintain the sharing of scientific information while minimizing risks to public health. He emphasizes that suppressing scientific knowledge was in the public interest in this instance, but that so-called dual-use research will continue to raise many questions about where to draw the line between freedom of information and public safety. Webster argues there is an urgent need for general guidance in the matter and he proposes creating an international panel to consider approaches to promoting research while maintaining biosecurity.

The final contributor, Vincent Racaniello of Columbia University, argues that NSABB was wrong to recommend suppressing the information in these studies. It is not known whether the ferret adapted virus is lethal or transmissible among humans, Racaniello says, and he points out that adapting viruses to living in lab animals is actually a common strategy for reducing their suitability and virulence to human hosts. He is also concerned about the precedent set by withholding details from a scientific publication. The idea that scientific studies can be published without methods and data will undermine the system of publication, replication and advancement that guides modern scientific endeavor.

The matter of the NSABB and the H5N1 research raises important questions for science and policy, the answers to which principled persons may disagree. The American Society for Microbiology has long contributed to national discussions on health and biosecurity, and it is hoped that the Commentaries appearing in mBio? on January 31 will stimulate a thoughtful and productive dialogue among the various stakeholders.

###

IN RELATED NEWS: The ASM will host a special session at its annual Biodefense and Emerging Diseases Research Meeting on February 29, featuring a live discussion of the H5N1 research controversy. Hosted by NSABB Chair Paul Keim, the session's participants will include Michael Osterholm of the Center for Infectious Disease Research and Policy, Anthony Fauci of the National Institutes of Health, Bruce Alberts of Science Magazine and Ron Fouchier of Erasmus MC. Additional information can be found online at http://www.asmbiodefense.org.

mBio? is an open access online journal published by the American Society for Microbiology to make microbiology research broadly accessible. The focus of the journal is on rapid publication of cutting-edge research spanning the entire spectrum of microbiology and related fields. It can be found online at http://mbio.asm.org.

The American Society for Microbiology is the largest single life science society, composed of over 39,000 scientists and health professionals. ASM's mission is to advance the microbiological sciences as a vehicle for understanding life processes and to apply and communicate this knowledge for the improvement of health and environmental and economic well-being worldwide.


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NSABB and H5N1 redactions: Biosecurity runs up against scientific endeavor

Genes Linked to Cancer Could Be Easier to Detect with Liquid Lasers

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EDITORS: See photo at: http://www.ns.umich.edu/new/releases/20189-genes-linked-to-cancer-could-be-easier-to-detect-with-liquid-lasers

Newswise — ANN ARBOR, Mich.—Using a liquid laser, University of Michigan researchers have developed a better way to detect the slight genetic mutations that might predispose a person to a particular type of cancer or other diseases.

Their results are published in the current edition of the German journal Angewandte Chemie.

This work could advance understanding of the genetic basis of diseases. It also has applications in personalized medicine, which aims to target drugs and other therapies to individual patients based on a thorough knowledge of their genetic information.

The researchers say their technique works much better than the current approach, which uses fluorescent dye and other biological molecules to find and bind to mutated DNA strands. When a patrol molecule catches one of these rogues, it emits a fluorescent beacon. This might sound like a solid system, but it's not perfect. The patrol molecules tend to bind to healthy DNA as well, giving off a background glow that is only slightly dimmer than a positive signal.

"Sometimes, we can fail to see the difference," said Xudong Fan, an associate professor in the Department of Biomedical Engineering and principal investigator on the project. "If you cannot see the difference in signals, you could misdiagnose. The patient may have the mutated gene, but you wouldn't detect it."

In the conventional fluorescence technique, the signal from mutated DNA might be only a few tenths of a percent higher than the background noise. With Fan's new approach it's hundreds of times brighter.

"We found a clever way to amplify the intrinsic difference in the signals," Fan said.

He did it with a bit of backtracking.

Liquid lasers, discovered in the late '60s, amplify light by passing it through a dye, rather than a crystal, as solid-state lasers do. Fan, who works at the intersection of biomedical engineering and photonics, has been developing them for the past five years. In his unique set-up, the signal is amplified in a glass capillary called a "ring resonator cavity."

Last year, Fan and his research group found that they could employ DNA (the blueprints for life that reside in all cells) to modulate a liquid laser, or turn it on and off. His group is one of just a few in the world to accomplish this, Fan said. At the time, they didn't have a practical application in mind. Then they had an epiphany.

"We thought, 'Let's look at the laser output. Can we see what's causing the different outputs and use it to detect differences in the DNA?'" Fan said. "I had an intuition, and it turns out the output difference was huge."

The journal editors named this a "hot paper" that "advances knowledge in a rapidly evolving field of high current interest."

The paper is titled "Distinguishing DNA by Analog-to-Digital-like Conversion by Using Optofluidic Lasers." The research was funded by the National Science Foundation. The first author is Yuze Sun, a doctoral student in the Department of Biomedical Engineering. The university is pursuing patent protection for the intellectual property, and is seeking commercialization partners to help bring the technology to market.

The University of Michigan College of Engineering is ranked among the top engineering schools in the country. At more than $130 million annually, its engineering research budget is one of largest of any public university. Michigan Engineering is home to 11 academic departments and a National Science Foundation Engineering Research Center. The college plays a leading role in the U-M Energy Institute and hosts the world-class Lurie Nanofabrication Facility. Michigan Engineering's premier scholarship, international scale and multidisciplinary scope combine to create The Michigan Difference. Find out more at http://www.engin.umich.edu.

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Danger. Your Reproductive DNA Has Been Scrambled. How To Make Spiritual Babies. Adrenal Mission. - Video

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Proposed Charleston DNA change conference 2012 - Video

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