Manmohan criticises NGOs for protests in Kudankulam

Prime Minister Manmohan Singh has criticised non-governmental organisations that receive support from abroad for stalling the use of genetic engineering in agriculture and leading protests against the Kudankulam nuclear power plant in Tamil Nadu.

In an interview published in the latest issue of journal Science, Dr. Singh pointed to the potential of biotechnology, saying “in due course of time we must make use of genetic engineering technologies to increase the productivity of our agriculture.”

But controversies had arisen. “There are NGOs, often funded from the United States and the Scandinavian countries, which are not fully appreciative of the development challenges that our country faces.”

Then, referring to the protests at Kudankulam, he said: “the atomic energy programme has got into difficulties because these NGOs, mostly I think based in the United States, don't appreciate need for our country to increase the energy supply.”

Asked whether nuclear power had a role in India despite the Fukushima disaster in Japan, he said, “Yes, where India is concerned, yes. The thinking segment of our population certainly is supportive of nuclear energy.”

On investment in R&D, he reiterated the view that such spending should be raised from about 1per cent of the GDP (Gross Domestic Product) to about 2 per cent. Public sector spending on research as a proportion of the GDP was “roughly the same” as that of other developing countries. “It is the private sector in our country which has to do a lot more.”

Over the next five years, the effort would be to gradually increase the proportion of money spent on R&D and at the same time “create a system of incentives which will induce the private sector to increase their spending on science and technology.”

To a question whether India was competing with China, he said the two countries were at a stage of development where both had to compete and cooperate.

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Manmohan criticises NGOs for protests in Kudankulam

DNA testing of felony suspects upheld by appeals court

A 2004 law requiring jailers to take DNA samples from anyone arrested for alleged felonies doesn't violate the prisoners' constitutional right to be free from unreasonable search and seizure, a divided federal appeals court ruled Thursday.

In a 2-1 ruling, the U.S. 9th Circuit Court of Appeals said the government's interests in solving crimes and positively identifying suspects outweigh the detainees' privacy concerns.

The panel majority -- both judges named to the federal bench by Republican presidents -- likened the minimally invasive oral swabbing of those entering the jails to fingerprinting, a decades-old booking practice for identification purposes that has been consistently upheld by the courts.

“DNA analysis is an extraordinarily effective tool for law enforcement officials to identify arrestees, solve past crimes, and exonerate innocent suspects,” Judge Milan D. Smith Jr. wrote in the opinion joined by a visiting federal judge from Tennessee.

But Judge William A. Fletcher dissented, arguing that 9th Circuit and U.S. Supreme Court case law make clear that DNA testing for investigative purposes requires a warrant and probable cause to believe a felony has been committed.

About a third of the 300,000 arrested on felony allegations each year in California aren't convicted, and many are never charged at all, said Fletcher, named to the court by President Clinton.

Three of the four lead plaintiffs in the class-action lawsuit brought on their behalf by the American Civil Liberties Union of Northern California had been arrested at demonstrations in the Bay Area against U.S. foreign policy and state college tuition hikes.

Elizabeth Haskell, who was arrested at a peace demonstration in San Francisco in 2009, was threatened with prosecution unless she submitted to the DNA collection but was never charged.

She told the court she considered the swabbing "an intimidation tactic" to deter her from exercising her free-speech rights.

Michael T. Risher, the ACLU lawyer who argued the case, said a petition for rehearing by the full 9th Circuit was likely and that he expected the judges to be inclined to reconsider the split panel ruling.

"This is clearly an issue where different reasonable judges have differing opinions and we’ll have to see how it ends up,” Risher said.

ALSO:

Blue Line delays expected during evening rush hour

Sheriff Baca backs driver's licenses for illegal immigrants

Teacher accused of having sex with students was removed last week

-- Carol J. Williams

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DNA testing of felony suspects upheld by appeals court

Posted in DNA

Court OKs Taking DNA From Felony Arrestees

Photo: AP/Thomas Kienzle

A federal appeals court Thursday upheld a voter-approved measure requiring California authorities to take a DNA sample from every adult arrested on felony accusations in the Golden State.

The American Civil Liberties Union, which brought the challenge in hopes of striking down the measure, argued that DNA sampling of arrestees was an unconstitutional Fourth Amendment search and privacy breach. A lower court had refused to stop the program that has resulted in California securing a DNA database of more than 1.5 million people.

“DNA analysis is an extraordinarily effective tool for law enforcement officials to identify arrestees, solve past crimes, and exonerate innocent suspects. After weighing these factors, we conclude that the government’s compelling interests far outweigh arrestees’ privacy concerns,” Judge Milan Smith Jr. wrote (.pdf) for the 2-1 appeals panel.

He added that DNA collection “is substantially indistinguishable from traditional fingerprinting as a means of identifying arrestees and, incidentally, tying arrestees to criminal investigations.”

At least 21 states have regulations requiring suspects to give a DNA sample upon an arrest. President Barack Obama supports taking DNA when a suspect is arrested.

Proposition 69, adopted in 2004 and fully implemented in 2009, requires adult detainees to provide a saliva, or sometimes a blood sample, upon felony arrest. The sample is stored in state and FBI databases, even if the arrested adult is never charged or convicted of a crime.

About 100,000 persons arrested for felonies in California are ultimately cleared every year.

In dissent, Judge William Fletcher disputed Smith’s reasoning.

I would conclude that Proposition 69 is unconstitutional. My reasoning is straightforward. Fingerprints may be taken from an arrestee in order to identify him — that is, to determine whether he is who he claims to be. But fingerprints may not be taken from an arrestee solely for an investigative purpose, absent a warrant or reasonable suspicion that the fingerprints would help solve the crime for which he was taken into custody. DNA samples are not taken from felony arrestees under Proposition 69 in order to identify them. Rather, they are taken solely for an investigative purpose, without a warrant or reasonable suspicion.

Judge Smith countered, saying Fletcher’s dissent was an “unprecedented and misguided reading of the Fourth Amendment.”

The lawsuit (.pdf) does not challenge DNA sampling for convicted felons or for DNA samples required by a court order.

The ACLU, like Fletcher, said DNA sampling is different from compulsory fingerprinting. A fingerprint, for example, reveals nothing more than a person’s identity. But much can be learned from a DNA sample, which codes a person’s family ties, health risks and, according to some, can predict a propensity for violence.

What’s more, in California, the authorities conduct so-called “familial searching.” That is when a genetic sample does not directly match another, so authorities start investigating people with closely-matched DNA in hopes of finding leads to the perpetrator. In 2010, for example,  California authorities arrested Lonnie David Franklin Jr. as the suspected “Grim Sleeper” serial killer, basing their case in part on a DNA match of crime scene evidence to a sample from his incarcerated son.

The courts have already upheld DNA sampling of convicted felons, based on the theory that the convicted have fewer privacy rights. Still, the U.S. Supreme Court has held that when conducting intrusions of the body during an investigation, the police need so-called “exigent circumstances” or a warrant. That alcohol evaporates in the blood stream is the exigent circumstance to draw blood from a suspected drunk driver without a warrant.

The plaintiffs in the case include an Oakland woman whose DNA was taken after she was arrested during a war protest in San Francisco and was never charged. Another plaintiff was arrested in Sacramento on accusations of being in possession of stolen properly. His DNA was taken and he was never charged.

Arrestees not convicted may petition the courts or the California Department of Justice to destroy and expunge their DNA profile. However, individuals must await the expiration of the statute of limitations for the crimes for which they were arrested before requesting expungement, unless prosecutors dismiss the charges sooner.

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Court OKs Taking DNA From Felony Arrestees

Posted in DNA

Court: California can force inmates to submit DNA

SAN FRANCISCO (AP) — A divided federal appeals court ruled Thursday that California law enforcement officials can keep collecting DNA samples from people arrested for felonies.

The 9th U.S. Circuit Court of Appeals said law enforcement's interest in solving cold cases, identifying crime suspects and even exonerating the wrongly accused outweigh any privacy concerns raised by the forced DNA collections.

The 2-1 ruling came in response to a lawsuit filed by four Californians who were arrested on felony charges but never convicted.

The arrestees sought a court order barring collection of DNA from people who are arrested but not convicted, arguing the process is an unconstitutional search and seizure since some suspects will later be exonerated.

The DNA samples are obtained with a swab of the cheek and stored in the state's DNA database, which contains 1.9 million profiles. Arrestees who are never charged with a felony can apply to have their samples expunged from the database.

The state Department of Justice said it has had roughly 20,000 "hits" connecting suspects with previous crimes since it began collecting the DNA profiles.

Judge Mylan Smith Jr., writing for the two-judge majority, said the useful law enforcement tool wasn't any more intrusive than fingerprinting.

"Law enforcement officers analyze only enough DNA information to identify the individual, making DNA collection substantially similar to fingerprinting, which law enforcement officials have used for decades to identify arrestees, without serious constitutional objection," wrote Smith, who also said investigators are prohibited by law from misusing the database.

Judge William Fletcher dissented, writing that fingerprinting a suspect is done exclusively for identification purposes. The DNA samples, he wrote, "are taken solely for an investigative purpose, without a warrant or reasonable suspicion."

Fletcher noted that one-third of the 300,000 people arrested in the state for felonies each year are never charged with felonies. He said the state's offer to remove those samples from the database for those who apply is onerous.

"Expungement is a lengthy, uncertain and expensive process, Fletcher said. "Arrestees seeking expungement must pay their own expenses and attorney's fees."

Fletcher said he believed the privacy rights of arrestees never charged with felonies should trump law enforcement's need to collect to the DNA.

The same issue is also making its way through the state court system. A Court of Appeal decision striking down the collection as unconstitutional was put on hold when the California Supreme Court agreed to hear the case.

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Court: California can force inmates to submit DNA

Posted in DNA

Southampton, Oxford Lands $6.3M Grant for Synthetic Biology

By a GenomeWeb staff reporter

NEW YORK (GenomeWeb News) – Researchers at the University of Southampton and the University of Oxford have netted a £4 million ($6.3 million) grant from the Biotechnology and Biological Sciences Research Council to develop a new synthetic biology technology that could aid in the production of useful DNA and RNA structures.

The team will use the funding, awarded under the strategic Longer and Larger program, to develop a technique for "clicking" DNA and RNA segments together that could make synthetic biology research projects cheaper, more efficient, and more scalable, BBSRC said this week.

The technology aims to address one of the difficulties of synthesizing DNA molecules that makes it slow and laborious — the development of large numbers of short DNA strands that are linked together using delicate enzymes. The "click" technique replaces those enzymes with chemical methods to create stronger links between DNA and RNA that make them more useful for industrial scale applications, according to Southampton professor Tom Brown, a joint leader on the project.

"This new technology is an important addition to the toolbox of molecular techniques that is allowing researchers to explore how biological systems function by creating simplified and modified biomolecular machinery," Andrew Turberfield, a professor at Oxford who is participating on the project, said in a statement.

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Southampton, Oxford Lands $6.3M Grant for Synthetic Biology

European Integrated Structural Biology Infrastructure launching

Public release date: 23-Feb-2012
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Contact: Yivsam Azgad
news@weizmann.ac.il
972-893-43856
Weizmann Institute of Science

Major transformations in biomedical science are on the horizon with the establishment of the world-class Integrated Structural Biology Infrastructure (Instruct) in support of European biomedical research.

The European Strategy Forum of Research Infrastructures (ESFRI) is involved in establishing about 40 such infrastructures, seven of them in biomedical sciences. Instruct is one such biomedical project, whose aim is to provide pan-European user access to state-of-the-art equipment, technologies and manpower in cellular structural biology. This will allow Europe to maintain a competitive edge and play a leading role in this vital research area.

The Weizmann Institute of Science, together with Tel Aviv University, has been chosen as one of the seven Core Centres, joining prestigious institutions in the UK, Italy, France and Germany.

"Structural Biology is a scientific area in which Israeli scientists have been leading for many years, as evidenced by Weizmann Institute's Prof. Ada Yonath, who won a Nobel Prize in 2009 for her pioneering work on solving the structure of ribosomes," says the Institute's Prof. Joel Sussman, Director of Israel's Instruct Core Centre.

Crucial to understanding how the living cell functions is knowledge of the three-dimensional structures of its proteins and nucleic acids, how these interact with one another, and their arrangement and dynamics within the cell. But no single discipline alone is able to decipher this. "In addition to the Weizmann Institute having developed world-class research programs in several of the disciplines relevant to Instruct, including electron microscopy, mass spectroscopy, X-ray crystallography, NMR, bioinformatics and structural proteomics, the Israel Structural Proteomics Center (ISPC) has played a synergistic role in integrating and coordinating all these various disciplines," says Sussman. The ISPC was established by scientists from the Weizmann Institute, with Sussman as its director, in order to increase the efficiency of protein structure determination.

Mirroring the philosophy of the ISPC, Instruct will merge the information obtained by the various structural biology methods and techniques in order to provide a dynamic picture of key cellular processes, both in vivo and in vitro, on all scales from individual macromolecules, through complexes and organelles to the whole cell. This knowledge will permit major advances in understanding and treating diseases.

"Instruct will allow laboratories throughout Europe to gain ready access to the most advanced facilities, technologies and methodologies. Israeli scientists and their European counterparts will now have access to facilities they could only have dreamed of before," says Weizmann Institute's Prof. Gideon Schreiber, Deputy Director of Israel's Instruct Core Centre, as well as of the ISPC. "We hope this core centre will stimulate new collaborative research projects between laboratories throughout Europe with the Weizmann Institute and with other Israeli institutions, and also attract more graduate students, postdoctoral fellows and visiting scientists from all over the world."

Instruct will formally be launched at a signing ceremony in Brussels on 23rd February, 2012, and Weizmann Institute Vice President Prof. Haim Garty will be signing on behalf of the Weizmann Institute, Tel Aviv University and the State of Israel.

###

More information can be found by visiting the Instruct Hub at http://www.structuralbiology.eu

Prof. Joel Sussman's research is supported by Mr. and Mrs. Yossie Hollander, Israel; the S. & J. Lurje Memorial Foundation; the Jean and Jula Goldwurm Memorial Foundation; the Samuel Aba and the Sisel Klurman Foundation; the Bruce H. and Rosalie N. Rosen Family Foundation; and Mr. and Mrs. Howard Garoon, Glencoe, IL. Prof. Joel Sussman is the incumbent of the Morton and Gladys Pickman Professorial Chair in Structural Biology.

The Weizmann Institute of Science in Rehovot, Israel, is one of the world's top-ranking multidisciplinary research institutions. Noted for its wide-ranging exploration of the natural and exact sciences, the Institute is home to 2,700 scientists, students, technicians and supporting staff. Institute research efforts include the search for new ways of fighting disease and hunger, examining leading questions in mathematics and computer science, probing the physics of matter and the universe, creating novel materials and developing new strategies for protecting the environment.

Weizmann Institute news releases are posted on the World Wide Web at http://wis-wander.weizmann.ac.il, and are also available at http://www.eurekalert.org.

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European Integrated Structural Biology Infrastructure launching

Science magazine honors biology lab that helps students design research

Public release date: 23-Feb-2012
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Contact: Natasha Pinol
npinol@aaas.org
202-326-7088
American Association for the Advancement of Science

Tammy Long got an idea of what science was all about when she went to Costa Rica as a college student.

"My instructors basically said, 'There's the rainforest. Go find something that you'd be interested in researching,'" she says. "That completely changed what I was going to do for a career. They had introduced me to inquiry."

Such a free-form approach might not have worked for every student?Long, now an assistant professor in plant biology at Michigan State University, was someone who had gravitated toward studying nature even as a child growing up in southwest Michigan. Still, asking her to follow her own curiosity about the rainforest made a strong impact and is somewhat similar to the approach used in her Campus Trees biology lab module, which inspires students to develop their own research methods. This month, Science magazine has chosen Campus Trees to win the Science Prize for Inquiry-Based Instruction.

The Science Prize for Inquiry-Based Instruction was developed to showcase outstanding materials, usable in a wide range of schools and settings, for teaching introductory science courses at the college level. The materials must be designed to encourage students' natural curiosity about how the world works, rather than to deliver facts and principles about what scientists have already discovered. Organized as one free-standing "module," the materials should offer real understanding of the nature of science, as well as providing an experience in generating and evaluating scientific evidence. Each month, Science publishes an essay by a recipient of the award, which explains the winning project. The essay about Campus Trees will be published on February 24.

"We're trying to advance science education," says Bruce Alberts, editor-in-chief of Science. "This competition provides much-needed recognition to innovators in the field whose efforts promise significant benefits for students and for science literacy in general. The publication in Science of an article on each laboratory module will help guide educators around the globe to valuable free resources that might otherwise be missed."

Long developed Campus Trees with Sara Wyse, an assistant professor of biological sciences at Bethel University. At the start, Long's goal was to restructure an introductory biology curriculum and redesign the lab portion of the class, which was taught by graduate teaching assistants. Wyse had begun researching the impact of alternative training on graduate TAs, and so the two involved TAs in their project early on. At a 2008 "boot camp" for the TAs, the teaching assistants agreed that biology lab should be about the process of science?how science answers questions by testing ideas and gathering and evaluating evidence?rather than as a series of preplanned steps. They also agreed that the research undertaken had to be "real," even if that meant outcomes would sometimes be unexpected, contradictory, or confusing.

"Instructors worry so much about having an experiment that's going to work, but it's important for students to come up with questions and methods of their own?and to live through some mistakes," says Long. "That's really where the richness of the learning comes in."

These educational goals were emphasized as Long, Wyse, and five TAs set out to develop Campus Trees, which became a semester-long study of phenology, or the patterns of recurrent natural events. Phenologic trends can be indicators of environmental change, including climate change. Taking the citizen science project known as the National Phenology Network as their model, they turned to the trees on the campus of Michigan State as their living laboratory.

Wanting to keep the science "real" and not wanting to prescribe a cookbook series of steps for the students in the lab, the developers were quickly confronted with the problem of how to produce consistent, reliable data. The conclusion was that the students themselves would develop their own methods for documenting the color change and dropping of the trees' leaves, for example, designing the methods, testing them, and then evaluating their effectiveness.

As Long points out, quantifying color in a tree is not straightforward, requiring some system for keeping an ongoing evaluation consistent.

"The students came up with crazy ideas for assessing color," says Long, referring to their innovative ideas of using a Twister spinner to randomly select which branches to sample, electronic color-pickers, and numberic RGB (red-green-blue) codes. "It was fantastic. They were so creative."

Students don't know at the beginning of the lab that multiple research teams are studying the same trees. When they discover this later in the process, they are asked to compare the techniques developed by the other teams to their own methods. Surprisingly, Long says, many students take this as a challenge, carefully considering which methods worked best for each type of research question being considered.

"Students learn firsthand about hypothesis development, data collection, and the value of sharing and maintaining databases," says Melissa McCartney, editorial fellow at Science. "Multiple samplings of the same trees by different groups show students how slightly different methods can yield different results, highlighting the important of tackling a research question with multiple approaches."

Long says the Campus Trees lab module is as much intended to train students to be science-literate, to understand how science works, as it is a training tool for students who will actually become scientists. At the same time, and in keeping with the philosophy that the research be real, the module is meant to provide usable data.

"What I hope is that we can start engaging our huge introductory classes in inquiry, and generate long-term data sets that can be used both for instruction and to serve the interests of researchers on campus," she says.

The IBI prize and corresponding essay in Science draw attention to this idea behind Campus Trees, a system of learning that Long feels is highly transferable and adaptable to other contexts and types of science research.

"I hope that winning this prize legitimizes the notion that we can use an inquiry approach to produce multiple benefits?to students, to their instructors, and to authentic research interests."

###

The American Association for the Advancement of Science (AAAS) is the world's largest general scientific society, and publisher of the journal, Science as well as Science Translational Medicine and Science Signaling. AAAS was founded in 1848, and includes some 262 affiliated societies and academies of science, serving 10 million individuals. Science has the largest paid circulation of any peer-reviewed general science journal in the world, with an estimated total readership of 1 million. The non-profit AAAS is open to all and fulfills its mission to "advance science and serve society" through initiatives in science policy; international programs; science education; and more. For the latest research news, log onto EurekAlert!, http://www.eurekalert.org, the premier science-news Web site, a service of AAAS.

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Science magazine honors biology lab that helps students design research

Research and Markets: Methods in Systems Biology – 2011 Comprehensively Covers the Methods in Systems Biology

DUBLIN--(BUSINESS WIRE)--

Research and Markets (http://www.researchandmarkets.com/research/c007b0/methods_in_systems) has announced the addition of Elsevier Science and Technology's new report "Methods in Systems Biology" to their offering.

Systems biology is a term used to describe a number of trends in bioscience research, and a movement which draws on those trends. This volume in the Methods in Enzymology series comprehensively covers the methods in Systems Biology. With an international board of authors, this volume is split into sections that cover subjects such as Machines for systems biology, Protein production and quantification for Systems Biology, and Enzymatic Assays in Systems Biology Research. This volume in the Methods in Enzymology series comprehensively covers the methods in Systems Biology.

With an international board of authors, this volume is split into sections that cover subjects such as Machines for systems biology, Protein production and quantification for Systems Biology, and Enzymatic Assays in Systems Biology Research.

Key Topics Covered:

Section 1 - Strategies in systems biology. top down, middle-out and bottom-up strategies - Hans V. Westerhoff

Section 2 - Machines for systems biology - Roy Goodacre. 4 chapters explaining the workings of four of the most important measurement techniques for systems biology: Mass spectrometry Microscopy Spectroscopy

Section 3 - Nucleic acids and systems biology - James Adaye. 4 Chapters on DNA sequencing, Arrays studies, PCR, deep sequencing

Section 4 - Protein production and quantification for Systems Biology - Naglis Malys and Kathleen Carroll. Chapter 1: Quantification of proteins and their modifications using QconCAT technology. Chapter 2: Mass spectrometric based quantitative proteomics using SILAC

Section 5 - Enzymatic Assays in Systems Biology Research Farid Khan, Hanan Messiha and Malgorzata Adamczyk. Chapter 1: Enzymatic Assays in Systems Biology Research: Strategies and challenges. Chapter 2: Real-time kinetic assay technologies for characterising enzymes in metabolic pathways.

Section 6 - Sample preparation in Metabolomics Studies - Warwick Dunn & Catherine Winder. Chapter 1 - The use of continuous culture in systems biology investigations. Chapter 2 - Metabolomic studies of yeast - methods for sample collection in profiling and quantitation studies

Section 7 - Mathematical modelling in Systems Biology - Kieran Smallbone & Evangelos Simeonidis. Chapter 1: Building a kinetic model of a metabolic pathway. Chapter 2: Making systems biology models reusable: the role of standards and biological semantics

Section 8 - Understanding systems biology (Hans Westerhoff). 1. Elementary mode analysis 2. Flux analysis 3. Flux balance analysis 4. Metabolic control analysis 5. Supply-demand analysis 6. Modular kinetic analysis

For more information visit http://www.researchandmarkets.com/research/c007b0/methods_in_systems

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Research and Markets: Methods in Systems Biology - 2011 Comprehensively Covers the Methods in Systems Biology

Winners at the 2012 Beaverton Hillsboro Science Expo

A Hillsboro student and three Beaverton students will head to Pittsburgh in May to compete in the Intel International Science and Engineering Fair.

The top four winners in the Beaverton Hillsboro Science Expo on Feb. 17 are becoming household names in the Washington County science arena: Tori Graf and Naomi Shah of Sunset High School, William Yuan of Westview High School and Raghav Tripathi of Westview High School.

Hillsboro High's Tori Graf

But dozens of other top category finishers in the regional fair have a second chance to qualify for the international competition if they win best of fair at the Intel Northwest Science Expo on March 23 at Portland State University.

The Beaverton Hillsboro Science Expo had a record 170 entries this year, compared to about 110 last year, said Susan Holveck, co-director of the expo.

Best of Fair – headed to Pittsburgh:
 
Tori Graf: "The Effects of Chemosensory on the Nutritional Behavior of Caenorhabditis elegans."
Naomi Shah: "The Toxicological Effect of Emissions From Building Materials on Lung Health."
William Yuan: "A Novel Design for the Enhancement of Anti-Reflection in Crystalline Photovoltaic Cells."
Raghav Tripathi: "Towards the Cure: Abnormal Protein Interactions Between Amyloid Beta and Tau as a Therapeutic Target for Alzheimer's Disease."

Most top category winners will compete at the Northwest Science Expo:

Category Winners
Animal Science -- First: Tori Graf, Hillsboro High School; second: Sebastian Singleton, Health and Science High School; third: Gena Tkachuk, Brody Stiefel, Century High School.
Behavioral and Social Sciences -- First: Raza Khan, Jonathan Chu, Merlo Station High School; second: Shreya Jain, Aishwarya Shimpi, Westview High School; third: Sarah Mireles, Hillsboro High School.
Biochemistry -- First: Anisha Das, Westview High School; second: Dulce Flores Cruz, Hillsboro High School; third: Sol Summers, Savan Patel, Beaverton High School.
Cellular and Molecular Biology -- First: Raghav Tripathi, Westview High School; second: Sr Kanna, Alden Moss, Merlo Station High School; third: Kyra Patton, Sunset High School.
Chemistry -- First: Arial Eatherton, Century High School; second: Dea Arozamena, Zachery Rogers, Liberty High School; third: Marlo Eckert, Brian Dunn, Glencoe High School.
Computer Science -- First: Tahsin Saffat, Westview High School: second: Muhammad Ridha, Merlo Station High School; third: Jerry Chen, Merlo Station High School.
Energy and Transportation -- First: Anisha Datta, Glencoe High School; second: Spencer Hastings, Century High School; third: Alex Chau, Jacom Gerber, Glencoe High School.
Engineering: Electrical and Mechanical -- First: William Yuan, Westview High School; second: Alan Cheng, Southridge High School; third: Matthias Guenther, Scott Merrill, Merlo Station High School.
Engineering: Materials and Bioengineering -- First: Christiana Logan, Glencoe High School; second: Danith Davis, Century High School; third: Daniel Kachmarek, Glencoe High School.
Environmental Analysis and Effects -- First: Naomi Shah, Sunset High School; second: Andrew Chen, Beaverton High School; third: Preeyam Roy, Westview High School.
Environmental Management -- First: Kiernan Garrett, Alessandra Elliott, Westview High School; second: Keawe Stubenberg, Liberty High School; third: Brylee Collins, Rimi Yoneya, Merlo Station High School.
Mathematical Sciences -- First: Edison Tsai, Merlo Station High School; second: Sidharth Dhawan, Westview High School; third: Aakash Jani, William Kim, Liberty High School.
Medicine and Health -- First: Amanu Haile, Westview High School; second: Adarsh Bhatt, Westview High School; third: Samantha Pham, Westview High School.
Microbiology -- First: Jared Wong, Beaverton High School; second: Kate Ratliff, Merlo Station High School; third: Christina Partillo, Beaverton High School.
Physics and Astronomy -- First: Aaron Pikus, Merlo Station High School; second: Nathan Ott, Merlo Station High School; third: Emma Orton, Century High School.
Plant Sciences -- First: Erin Lake, Liberty High School; second: Josh Carnahan, Morgan Rennekamp, Beaverton High School; third: Catherine Bayer, Hillsboro High School.
 
Special Awards
Outstanding Project in an Atmospheric Science Exhibit (sponsored by American Meteorological Society) -- Kiernan Garrett, Alessandra Elliott, Westview High School; Abraham Teklu, Glencoe High School.
Outstanding Geoscience Project (sponsored by the Association of Women Geoscientists) -- Brylee Collins, Rimi Yoneya, Merlo Station High School.
NOAA's Taking the Pulse of the Planet (sponsored by National Oceanic and Atmospheric Administration) -- Kiernan Garrett, Alessandra Elliott, Westview High School.
Award for Excellence in Scientific Research in Environmental Health (sponsored by Oregon Environmental Health Association) -- Naomi Shah, Sunset High School.
Sustainable Development Award (sponsored by Ricoh Corporation) -- Naomi Shah, Sunset High School; Preeyam Roy, Westview High School.
Outstanding Project in In Vitro Biology (sponsored by Society for in Vitro Biology) -- Sr Kanna, Alden Moss, Merlo Station High School.
U.S. Regional Stockholm Junior Water Prize (sponsored by Water Environment Federation) -- Brylee Collins, Rimi Yoneya, Merlo Station High School; Carson List, David Lim, Merlo Station High School; Allie Sanchez, Merlo Station High School; Preeyam Roy, Westview High School.
Outstanding Project in Materials Science (sponsored by ASM International Foundation) -- Christina Zimmerman, Morgan Scarbrough, Glencoe High School.
Intel Excellence in Computer Science (sponsored by Intel Corporation) -- Tahsin Saffat, Westview High School.
Mu Alpha Theta Award (sponsored by Mu Alpha Theta) -- Pruthvi Nannapaneni, Merlo Station High School; Sidharth Dhawan, Westview High School.
Innovative Engineering Award (sponsored by National Society of Professional Engineers) -- Humphrey Chen, Vinayaka Thompson, Merlo Station High School.
Outstanding Project by an 11th Grade Student (sponsored by Yale University Science and Engineering Association) -- Ankit Gupta, Kevin Wang, Westview High School.
Outstanding Use of the International System of Units (sponsored by U.S. Metric Association) -- Raghav Tripathi, Westview High School; Naomi Shah, Sunset High School.
Outstanding Research in Psychology (sponsored by American Psychological Association) -- Shreya Jain, Aishwarya Shimpi, Westview High School.
Army Awards for Scientific and Engineering Excellence (sponsored by Army Research Office, U.S. Army) -- Edison Tsai, Merlo Station High School; Shreya Jain, Aishwarya Shimpi, Westview High School; William Yuan, Westview High School.
Army Outstanding High School Project (sponsored by Army Research Office, U.S. Army) -- Shreya Jain, Aishwarya Shimpi, Westview High School.
Naval Excellence in Science and Engineering Award (sponsored by Office of Naval Research, U.S. Navy and Marine Corps) --Tahsin Saffat, Westview High School; Ankit Gupta, Kevin Wang, Westview High School; Pruthvi Nannapaneni, Merlo Station High School; Naomi Shah, Sunset High School.
U.S. Air Force Outstanding Project (sponsored by U.S. Air Force) -- Muhammad Ridha, Merlo Station High School; Matthias Guenther, Scott Merrill, Merlo Station High School; William Yuan, Westview High School.
Women in Engineering (sponsored by Intel Corporation) -- Arial Eatherton, Century High School.
Peers' Choice Award – Hillsboro (sponsored by Intel) -- Tori
Graf, Hillsboro High School.
Peers' Choice Award – Beaverton (sponsored by Intel) -- Aaron Pikus, Merlo.

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Winners at the 2012 Beaverton Hillsboro Science Expo

Understanding Lent and the Science of Self-Denial

When it comes to good-time holidays, Lent does not rank very high. Nor do Ramadan or Yom Kippur, of course, and no wonder. They are all about saying no to something (or many things) you love. Where's the egg nog and holiday joy in all that? But we observe these less-than-festive celebrations all the same -- and we have good reason to do so. There are hidden benefits to so much ritualized self-denial.

One of the open secrets of all religions is that even if you don't care for the priestly raiment in which their traditions come draped, some of them can be very healthy all the same. And those, like Lent, whose secular message is nothing more complicated than practicing self-control, can be among the most salutary of all -- something science is beginning to prove.

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Willpower is a quality that can be in short supply in all of us but it's one that, as we report in this week's TIME, is increasingly seen as cultivatable. Indeed, the best way to think of willpower is not as some shapeless behavioral trait but as a sort of psychic muscle, one that can atrophy or grow stronger depending on how it's used. What's more, neurologists and behavioral psychologists generally think of willpower as what's known as "domain general," which means that the more you practice it to control one behavior -- say, overeating -- the more it starts to apply itself to other parts of your life like exercising more or drinking less.

Roy Baumeister, a psychologist at Florida State University and author of the straightforwardly titled book Willpower, has conducted experiments in which subjects were given uncomfortable tasks to perform in a lab, such as holding their hand in ice water or squeezing an exercise grip. They were then sent home and given a random rule to observe for two weeks -- not swearing, say, or using the non-dominant hand for certain things like opening doors. After that period was over, they returned to the lab. Those subjects who had been assigned a rule and had followed it did better on their ice water or hand grip tasks when they tried them again than a control group that had been given no such homework. The two weeks of practicing resolve seemed to have generalized itself to other situations.

"An Australian group did something similar," says Baumeister. "They had people work on a problem in their lives -- like managing money -- for two weeks. Then they came back and had to focus on a computer task that involved catching three moving triangles while a distracting comedy video played. Doing the work at home seemed to improve their motivation in the lab."

(MORE: The Science of Favoritism: Why Mom Likes You Best)

The precise mechanism at work here is not clear. Changes in behavior are often reflected in -- or enabled by -- changes in the brain, but studies with functional magnetic resonance imaging (fMRI) have not yet shown any physical differences in the brains of people who practice lab-assigned discipline tasks. Still, other kinds of focus and training do change the brain.

"Both exercise and meditation lead to greater neuron density in the prefrontal cortex," says Kelly McGonigal, a psychologist at Stanford University and author of the new book The Willpower Instinct. It's in that region that executive skills such as impulse control and judgment live -- making it a very good place to be adding neuronal connections. Even if the short-term exercises Baumeister assigns don't have the same demonstrable effect, McGonigal has little doubt that they still "train up the skill set involved in self-awareness and practicing habits consistent with your goals."

That sense of conscious adherence and regular practice is precisely the reason religious observances that prescribe strict rituals of self-denial can be so powerful. Every time an observer of Lent craves -- and resists the lure of -- a forbidden indulgence is a tiny reminder of a commitment made. The same is true for Muslims who tolerate their Ramadan hunger until the sun goes down. And while the 24 hours of Yom Kippur do not provide the same weeks-long training the other holidays do, the rules are stricter -- with no food, no water, no bathing or washing, from sundown to sundown. Most of the day is spent in synagogue as well, which can be a trial of its own for people growing woozy with hunger.

(MORE: The Secrets of Self-Control)

The expressed liturgical purpose of all of these holidays is to teach piety, humility and submission and to atone for wrongs. But present-day spiritual leaders also speak of just the kind of willpower calisthenics the scientists do, though they call it "transfer training." Prohibitions against shellfish and pork in Jewish homes may have begun long ago with health concerns over the cleanliness of both foods, but modern inspections have effectively eliminated that worry. Still when you can pass up bacon no matter how good it smells or say no to a just-boiled lobster with a cup of drawn butter, that same facility with discipline can be applied to other areas of your life.

Distilling religious ritual down to scientific principle can be tricky -- not just because it diminishes the more transcendent experiences of believers but because it can seem to justify a sort of cynical dismissiveness in non-believers. But -- culture-war absolutism not withstanding -- both truths can exist simultaneously. A vigorous workout at your gym may make you feel great -- but so can a joyous round of gospel singing, clapping and foot-stomping. Are rising endorphins and lower cortisol levels involved in both? Probably. But is that all that's going on? Not to the believers it isn't.

The best thing about science is that hard, empirical answers are always there if you look hard enough. The best thing about religion is that the very absence of that certainty is what requires -- and gives rise to -- deep feelings of faith. Lent -- and Ramadan and Yom Kippur -- teach both.

Kluger is a senior editor at TIME and the author The Sibling Effect. The views expressed are solely his own.

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Understanding Lent and the Science of Self-Denial

Life Extension Foundation Sponsors New Show Featuring Suzanne Somers on Lifetime Television

FORT LAUDERDALE, Fla., Feb. 23, 2012 /PRNewswire/ -- Life Extension®, a pioneer in supporting and reporting the latest anti-aging research and integrative health therapies has announced it will sponsor The Suzanne Show, on Lifetime Television featuring Suzanne Somers.  The show is scheduled to premiere in May, on Wednesday mornings at 7 a.m. in eastern- and pacific-time zones for 13 weeks.  All programs will be re-aired during weekend editions of Lifetime Real Women.

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According to Rey Searles, Life Extension's marketing director, the show will include Suzanne Selects Health Tips and educational segments, as well as discuss top critical health issues, wellness and life-span extension, and educate viewers about science-based clinical research.

"Life Extension is excited to sponsor the premiering season of The Suzanne Show," said William Faloon, co-founder of the Life Extension Foundation. "We seek to educate consumers on how they can achieve healthier, happier and longer lives. So it is inevitable that we have partnered with Suzanne on this incredible adventure that is sure to positively impact people's lives."

The Life Extension Foundation provides its members vital health information that is overlooked by practicing physicians. Life Extension's 32-year track record shows they have been decades ahead of conventional medicine in identifying validated methods to prevent and treat age-related disorders.

The core mission of Life Extension is to extend the healthy human lifespan using an integrative approach and funding cutting edge scientific research. For more Life Extension information visit http://www.LEF.org, http://www.Twitter.com/LifeExtension, http://www.Facebook.com/LifeExtension and http://www.YouTube.com/LifeExtensionVideos.

Contact:
Sheldon Baker, Director of Public Relations
Life Extension
954.202.7739
Cell 559.287.7191
SBaker@LifeExtension.com

 

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Life Extension Foundation Sponsors New Show Featuring Suzanne Somers on Lifetime Television

Anatomy of a survey gone bad

February 23, 2012, 4:27 AM PST

Takeaway: Surveys seem to be marketers go-to sales device these days. But if you look closely, you’ll find that they’re not always on the up and up.

Sometimes, I get a press release that really irks me. Most of the time it has something to do with survey results. Either the survey bears out some obvious fact that makes me wonder why time, money and effort were even wasted on it, or the “sponsor” of the survey, astoundingly enough, profits in some way from the positive results.

You’ve probably seen those emails whose subject lines scream “Football now America’s favorite pastime!”, and then in tiny letters in the body copy you see “…sponsored by the NFL.”

So you can imagine how much eye-rolling I did upon getting what looked like the National Enquirer of emails that screamed “Americans willing to divorce in order to work from home!”

Upon opening the email, you see that 5 percent of the people surveyed said that they would divorce in order to be able to telecommute. Now, maybe it’s me, but why would that be a choice? And here are some of the other “findings” from the survey:

Social media - 34% Texting - 30% Chocolate - 29% Smartphone - 25% Shopping - 20% A salary increase - 17% Half of vacation days - 15% Daily showers - 12% Spouse - 5% (just so you know, people in the West were significantly more likely to say they would give up their spouse (7%) in order to telecommute than people in the Midwest (2%).)

First of all, chocolate? In what nightmare (dare I say, apocalyptic?) scenario would one be asked to give up chocolate in order to telecommute? And how does that even make sense? (How is a Cadbury Egg related to telecommuting? Huh? Somebody tell me that!) Oh yeah, and the divorce thing is weird too.

Then you check out this survey’s sponsor-TeamViewer. TeamViewer is, coincidentally, a “provider of remote control and online meetings software.” So needless to say, they have their reasons to want telecommuting to be something people would sacrifice measurably for.

I’m bright enough to put a survey in perspective on that basis. But when they get into the phrasing of survey questions that are supposed to bear out some relevant fact but are kind of meaningless, then I get a little perturbed.

Case in fact: Here’s some more of the survey’s findings:

Most Americans believe that more people want the option to telecommute (62%) with an overwhelming percentage (83%) believing that telecommuting is on the rise.

That doesn’t mean that most Americans want the option to telecommute. It means that most Americans think that more people want the option to telecommute. Got that? So of all the people asked, “Do you think more people want to telecommute these days?” sixty-eight percent said yes. Big freakin’ deal. That tells me nothing as to whether telecommuting numbers are up or down, or whether the concept is becoming more popular among working folks.

Just be careful when looking at survey results.

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Anatomy of a survey gone bad

MediVet-America Partners With Butler Schein Animal Health to Distribute World’s Leading Animal Stem Cell Technology to …

Global leader in animal stem cell technology is poised for significant expansion through new partnership with top U.S. companion animal health distribution company.

Las Vegas, Nevada (PRWEB) February 22, 2012

MediVet-America, the global leader in veterinary stem cell technology and regenerative medicine, has entered into a distribution partnership with Butler Schein Animal Health, a division of Henry Schein, the leading companion animal health distribution company in the U.S., to sell and distribute stem cell kits and equipment to veterinarians serving the nation’s fast-growing $50 billion pet industry.

The announcement was made today at the Western Veterinary Conference in Las Vegas by Jeremy Delk, CEO of MediVet-America.

The two companies will partner to sell and distribute MediVet-America’s advanced stem cell technology to more than 26,000 veterinary clinics nationwide. Adult animal stem cell technology uses the body’s own regenerative healing power to help treat dogs, cats, horses and other animals suffering from painful arthritis, hip dysplasia and tendon, ligament and cartilage injuries and other ailments.

The Adipose-Derived Stem Cell Procedure Kit and state of the art equipment, co-developed with Medical Australia, enable veterinarians to remove a small sample of fat, separate the stem cells, then activate and inject them into affected areas.

“We are pleased to be teaming up with Butler Schein, the largest companion animal health distribution company in the nation,” said Delk. “Their strong track record in sales and distribution will further fuel our rapid growth and bring this breakthrough technology to more leading veterinary practices across the country.”

To introduce the distribution partnership, Delk said MediVet-America has developed an exclusive program of product and service offers that will be made available only to Butler Schein customers.

Veterinary practitioners in more than 200 markets throughout 42 states now perform the drug-free procedure entirely in their own clinics more quickly, effectively and economically than earlier generation animal stem cell therapy. MediVet-America’s new treatment, developed in Australia, is available in 26 countries worldwide.

“This exciting partnership will allow even more of our colleagues unparalleled access to MediVet-America’s superior technology, providing the most affordable and efficacious stem cell therapy in the industry,” said Mike Hutchinson, D.V.M., the world’s leading animal stem cell practitioner. Dr. Hutchinson, who has spoken around the world about stem cell therapy, most recently in Tokyo, has performed more than 300 procedures over the last 18 months in his practice near Pittsburgh, PA.

Partnering with the leading animal health manufacturers in the world, Butler Schein maintains an order-fill ratio greater than 98 percent, and is positioned to bring the broadest selection of veterinary products and strategic business solutions to veterinarians, including:

    A comprehensive product offering for companion animal, equine and large animal practices including biologicals, diagnostics, nutritionals, parasiticides and pharmaceuticals

    Technology hardware and software solutions     Capital equipment, supply products and repair services     Practice design and remodeling, client marketing and financial solutions

Stem cells are basic biological cells with the ability to differentiate into specialized tissue cells and regenerate new cells to replace or repair damaged tissue. The stem cells used in veterinary medicine are not embryonic, which have attracted controversy over the years, but are taken from adipose (fat) tissue of the adult animal.

Americans spent an estimated $50.8 billion in 2011 on their companion animals, according to the American Pet Products Association, up from $28.5 billion in 2001. MediVet-America’s stem cell treatment costs about $1,800 for small animals, $2,400 for horses. Stem cells also can be frozen and banked for future use through MediVet Lab Services.

MEDIVET-AMERICA

A research and development company and global leader in veterinary stem cell technology, MediVet-America provides innovative cell applications for the therapeutic care of animals. Headquartered in Nicholasville, Kentucky, MediVet-America develops advanced cellular designed kits and services for the treatment of arthritis and degenerative joint disease. The company also offers MediVet Lab Services in multiple locations around the world that provides technical support for in-house stem cell vets, as well as regional and national Adipose stem cell processing and cryo banking services for pets at a young age or for a maintenance program, autologous conditioned serum processing, and cell counting for in-house stem cell procedures. http://www.MediVet-America.com

BUTLER SCHEIN ANIMAL HEALTH

Butler Schein Animal Health is the leading U.S. companion animal health distribution company. Headquartered in Dublin, Ohio, the company operates through 18 distribution centers and 12 telecenters. Approximately 900 Butler Schein Animal Health team members, including 300 field sales representatives and 200 telesales and customer support representatives, serve animal health customers in all 50 states. http://www.ButlerShein.com

###

Dick Roberts
Roberts Communications
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MediVet-America Partners With Butler Schein Animal Health to Distribute World's Leading Animal Stem Cell Technology to ...

And you can tell everybody, this is your mouse’s song

Otherwise titled: Your mouse sounds JUST like his dad!

Hoffman et al. “Spectrographic analyses reveal signals of individuality and kinship in the ultrasonic courtship vocalizations of wild house mice” Physiology and Behavior, 2012.

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Obviously, we’ve known about mice “squeaking” for ages. Some of them even HOWL. But mice also communicate with sounds that are too high pitched for humans to hear. These ultrasonic vocalizations (USVs) are used primarily by male mice, and the male mice make them when they scent or are near a likely lady. Female mice apparently like being serenaded, they respond to male’s USVs, and can even distinguish between the USVs of their close kin vs the USVs of unrelated mice.

So we know that females can discriminate between close kin USVs and non-kin USVs. Is this because they simply memorize the ones closest to them and look for ones that are different? Or is there something addition, say that male mice USVs can reveal kinships between mice?

To test this, the authors of this study captured a bunch of wild house mice (laboratory mice won’t work here, you wouldn’t be able to really determine kinship vs non, each strain is inbred to have the same DNA, so unless you compared strains…). They cross bred the wild house mice together in the lab to make sure everyone had the same social background and age, and recorded the mice calling. They pulled apart the recordings and classified them by the types of sounds, and the similarities between the calls in related and non-related mice. And it turns out that, when translated into tones that human ears can hear, mouse USVs sound a lot like bird chirps.

Mouse Serenade

And they have things in common with bird chirps as well: kinship and individuality.

This is what a mouse USV “looks” like. You can see that mice can emit these sounds at two levels at the same time, with a high ultrasonic pitch (at the bottom of the graphs), and a higher harmonic (at the top, which is a multiple of the first pitch). The harmonic is optional, many just contain the top pitch and are more “whistles”. And they clearly emit them in different patterns as well. When they compared previous vocalizations between mice that were related or not, they found that closely related mice ‘sound’ like each other, with similarity between 93% of the lower harmonics and 89% of the higher ultrasonic pitch.

Here you can see two sibling male mice. Their vocal calls “look” extremely similar. But it turns out that related males don’t just sing the SAME song. Their USVs have their own original variations as well. While the USVs show high relationships with kin, each mouse also has his own special chirp.

This graph depicts the USVs of their tested mice. You can see that there is overlap between some individuals, but that each individual is also somewhat distinct.

Of course this leaves us with more questions. How do male mice “learn” their USVs? Is it innate or do they pick it up from closely related mice? Do the calls contain any indications of the “quality” of the male (is it related to higher hormone levels or dominance, for example) and will females choose a male for specific aspects of their calls?

And what about the silent males? In their studies, three of the male mice never called at all, and this apparently takes place in both the laboratory and the wild. What about these ‘silent’ mice? Are there other more effective mechanisms for attracting mates?

But until we can answer these questions, we can imagine our little furry friends twittering soft little love songs. And know that female mice know the difference.

Hoffmann, F., Musolf, K., & Penn, D. (2012). Spectrographic analyses reveal signals of individuality and kinship in the ultrasonic courtship vocalizations of wild house mice Physiology & Behavior, 105 (3), 766-771 DOI: 10.1016/j.physbeh.2011.10.011

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And you can tell everybody, this is your mouse's song

NinePoint Medical Initiates Clinical Trial of Nvision VLE Imaging System; Program On Track for Commercial Launch in 2013

CAMBRIDGE, Mass.--(BUSINESS WIRE)--

NinePoint Medical, Inc., an emerging leader in the development of medical devices for in vivo pathology, today announced that the company has initiated a clinical trial to evaluate high-resolution optical imaging of Barrett’s esophagus using its proprietary Nvision VLE Imaging System, which received 510(k) clearance from the U.S. Food and Drug Administration (FDA) earlier this year. NinePoint Medical also announced the expansion of its executive leadership team with the appointment of Patrick MacCarthy to vice president of marketing.

The single-arm, open-label observational trial is designed to evaluate the performance of the Nvision VLE Imaging System to visualize subsurface tissue in patients undergoing esophagogastroduoenoscopy (EGD) for suspected or confirmed Barrett’s esophagus, a condition that is one of the most common precursors to esophageal cancer. The trial is expected to enroll approximately 100 patients at five leading centers worldwide, including the Mayo Clinic in Jacksonville, Fla. and Rochester, Minn.; Kansas University Medical Center in Kansas City, Mo.; Academic Medical Center in Amsterdam; University College London; and University Hospital in Nantes, France.

In January, NinePoint Medical announced 510(k) clearance from the FDA to market its Nvision VLE Imaging System for use as an imaging tool in the evaluation of human tissue microstructure by providing two-dimensional, cross sectional, real-time depth visualization. The Nvision VLE Imaging System is a next-generation optical imaging technology designed to enable physicians and pathologists, for the first time, to view high-resolution, volumetric images of organs and tissues in real time. The Nvision VLE Imaging System is the first volumetric optical coherence tomography (OCT) device cleared by the FDA for endoscopic imaging that uses a circumferential scanning technique and an automatic pullback to generate cross sectional and longitudinal images simultaneously in real time.

“The Nvision VLE Imaging System has the potential to improve and accelerate the diagnosis and treatment of patients with potentially diseased tissues, including gastrointestinal conditions like Barrett’s esophagus, by providing physicians with high-resolution, volumetric images in real time,” said Charles Carignan, M.D., president and chief executive officer of NinePoint Medical. “We have made rapid and significant progress in advancing the development of this technology, including 510(k) clearance from the FDA for a general indication and the initiation of this clinical trial for use in patients with Barrett’s esophagus as planned. We also are pleased to welcome Patrick to our team at this pivotal time. His broad medical device expertise will be invaluable as we continue to strengthen our management team and prepare for the commercial launch of the Nvision VLE Imaging System next year.”

Mr. MacCarthy brings to NinePoint Medical more than 10 years of marketing and sales expertise within the medical device and technology sectors. Mr. MacCarthy joins NinePoint Medical from Olympus America, Inc., where he was an integral member of the leadership team for Olympus’ flagship medical device and equipment business. Most recently, Mr. MacCarthy was vice president of marketing, responsible for marketing and strategic planning in the endoscopy division. Prior to that, he held positions of increasing responsibility at Olympus, including vice president / business unit leader and executive director of marketing, both in the endotherapy division. Mr. MacCarthy holds a Bachelor of Science in mechanical engineering from Colorado School of Mines.

For more information on NinePoint Medical’s clinical trial, please visit http://www.clinicaltrials.gov.

About NinePoint Medical, Inc.

NinePoint Medical, Inc. is a transformational medical device company developing innovative, real-time, in vivo pathology devices focused on dramatically improving patient care. Through its proprietary Nvision VLE Imaging System, NinePoint intends to bridge the gap between the diagnosis and treatment of disease. The Nvision VLE Imaging System will enable physicians and pathologists, for the first time, to view real-time, high-resolution, volumetric images of organs and tissues up to 3mm deep at less than 10 micron resolution. Initially, NinePoint is focusing on devices that enable real-time, endoscopic screening and surveillance of diseases of the mucosa of various tissues that are often precancerous. Eventually, the company intends to develop medical devices that provide physicians with immediately actionable information, which will allow them to diagnose and treat patients during the same procedure. This convergence of access, diagnosis and treatment during one procedure is expected to improve patient experiences and outcomes, improve the efficiency of care and provide important savings to the health care system. Headquartered in Cambridge, Mass., NinePoint is backed by Third Rock Ventures and Prospect Venture Partners. For more information, please visit http://www.ninepointmedical.com.

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NinePoint Medical Initiates Clinical Trial of Nvision VLE Imaging System; Program On Track for Commercial Launch in 2013

New Pattern Identifies Cells That Pose Risk of Tumors in Gonadal Dysgenesis Patients

Newswise — Pediatric and Developmental Pathology – Gonadal dysgenesis—defective development of the ovaries or testes— may also bring with it an increased risk of gonadal tumors. A recent discovery at the histologic level could help identify cells at risk of conversion into a tumor. For patients with XY gonadal dysgenesis, this means earlier detection and treatment of tumors.

A study in the current issue of the journal Pediatric and Developmental Pathology retrospectively examined gonads from 30 patients with gonadal dysgenesis. Cytogenic analyses were performed, investigating specifically the role of a primitive tissue known as “undifferentiated gonadal tissue.”

The complex processes of sexual development and differentiation into male or female can be disrupted in many ways. Pure, or complete, gonadal dysgenesis and mixed gonadal dysgenesis are among the most frequently occurring of these disorders. X/XY gonadal mosaicism, has been shown to play a role in disorders of sexual differentiation.

Undifferentiated gonadal tissue describes the presence of persistent primitive sex cords containing immature germ cells. These immature germ cells represent a risk factor for gonadal tumors. They hold the possibility of neoplastic transformation into a tumor.

The authors advise that germ cells in gonadal streaks should not be overlooked. Of 13 gonads in this study that were found to have both undifferentiated gonadal tissue and a streak, 9 developed a tumor.

About 30 percent of patients with pure gonadal dysgenesis, and 15 percent with mixed gonadal dysgenesis go on to develop gonadal tumors. These are mostly ganodoblastomas, which are benign, but in 60 percent of these cases, the patients may develop malignant tumors. Finding the etiology of these neoplasms is an essential step in stopping their development.

Full text of the article, “Undifferentiated Gonadal Tissue, Y Chromosome Instability, and Tumors in XY Gonadal Dysgenesis,” Pediatric and Developmental Pathology, Vol. 14, No. 6, 2011, is available at http://www.pedpath.org/toc/pdpa/14/6.

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New Pattern Identifies Cells That Pose Risk of Tumors in Gonadal Dysgenesis Patients

Research and Markets: The Evolving Field of Digital Pathology – Digital Health NOW Spotlight Report

DUBLIN--(BUSINESS WIRE)--

Research and Markets(http://www.researchandmarkets.com/research/548166/digital_health_now) has announced the addition of the "Digital Health NOW Spotlight Report: The Evolving Field of Digital Pathology" report to their offering.

Digital pathology is a disruptive technology; however, the consensus is that digital pathology is clearly our future. This iteration of Branham's Digital Health NOW Spotlight report takes a look at the emerging Digital Pathology market segment in health care. The report provides an overview and a general understanding of Digital Pathology rather than a detailed discussion of underlying technologies and vendors.

Digital pathology is rapidly gaining momentum as a proven and essential technology that is helping to reduce laboratory expenses, improve operational efficiency, enhance productivity and improve treatment decisions and patient care. It is used worldwide in drug development, reference lab, hospital, and academic medical centre settings. Applications include education, research, image analysis, archival and retrieval, LIS/LIMS integration, secondary consultations and virtual slide sharing. However, widespread adoption of digital pathology has been hindered not only by cost and technical factors but also largely by the mind set of technophobic pathologists.

Key Topics Covered:

What is Digital Pathology?

Steps in Digital Pathology Scanning Quantitative Analysis and Computer-Assisted Image Data Mining Pathology Image Management and Storage

Benefits of Digital Pathology

Dramatic Reduction in Misdiagnosis Remote Diagnosis and Support Educational Benefi ts

Market Trends

Evolving Market Validation is Still Incomplete Archival and Retrieval Systems Regulatory Challenges Sluggish Growth Lack of Standards Telepathology Vendor Landscape

Final Thoughts

For more information visit http://www.researchandmarkets.com/research/548166/digital_health_now

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Research and Markets: The Evolving Field of Digital Pathology - Digital Health NOW Spotlight Report

Maasin City eyes top nutrition award

Tuesday, February 21, 2012

MAASIN CITY -- The City Government aims to keep its title as nutrition champion in Eastern Visayas until 2014 in a bid to capture the Nutrition Honor Award (NHA) by the National Government.

NHA is the highest recognition given by the National Government to areas working to curb malnutrition.

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Mayor Maloney Samaco said he wants to replicate the feat of Limasawa, Southern Leyte, an NHA recipient last year. The island municipality is the first local government unit (LGU) in the region to receive the award.

“We want to be the second NHA awardee after Limasawa. It will be more challenging to us because our population is 86,000, while Limasawa is only 6,000,” Samaco told Leyte Samar Daily Express.

He said their goal is to bring down the malnutrition rate to only one percent just like Naga City, one of the first NHA awardees in the country.

“We have been implementing innovative programs to address malnutrition. That resulted in reduction of prevalence of underweight children from 10 percent in 2007 to only five percent this year,” Samaco added.

The city has been known for garnering the Green Banner Award in 2004, 2005, 2006, 2009, 2010, and 2011. The LGU is the Crown awardee last year.

If they will be able to maintain as Crown awardee in three years, the City Government will receive the highest recognition.

The national evaluation team is set to visit on April 10-11 this year to assess the nutrition program efficiency and effectiveness, which include the management of city nutrition program and changes in nutritional status of children.

“The challenge for the city is to attain the first year Crown maintenance award in 2012, second year maintenance in 2013 and get the Nutrition Honor Award in 2014,” said NNC Regional Nutrition Program Coordinator Carina Santiago.

Samaco said they are stepping up their fight against malnutrition by providing interventions to pregnant women to ensure that babies are in good health.

“I looked at nutrition as the future of our children. If we will take care of the younger generation, they will have a brighter future. Malnutrition will affect the children’s physical health an intellect. We invest considerable sum for nutrition programs,” he stressed. (Leyte Samar Daily Express)

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Journal of Clinical Microbiology Publishes Study Demonstrating Accuracy and Specificity of Great Basin Corporation’s …

SALT LAKE CITY, Feb. 22, 2012 /PRNewswire/ -- A study published in the March 2012 issue of the Journal of Clinical Microbiology demonstrates that Great Basin Corporation's Staph ID/R rapid, automated DNA multiplex assay can identify major pathogenic strains of Staphylococcus to the species level as well as the presence or absence of the methicillin-resistance determinant gene, mecA. In this study, the assay was 99 percent accurate in comparison to DNA sequencing results.

Staphylococcal infections are one of the leading causes of hospital acquired infections (HAI) worldwide, and up to 60 percent of all staphylococcal infections are methicillin resistant (MRSA). More than 2 million people are diagnosed with an HAI in the U.S. each year, causing approximately 90,000 deaths. Studies have shown that reducing the time to diagnose patients with staphylococcal infections decreases the length of stay at hospitals as well as the rates of morbidity and mortality.

"Great Basin is focused on developing low-cost technology that enables healthcare providers to diagnose patients faster, resulting in better patient outcomes and decreased costs associated with unnecessary tests," said Ryan Ashton, CEO and president, Great Basin Corporation. "The results of this study are particularly encouraging, especially since staphylococcal sepsis infections, such as MRSA, remain an important public health problem that still lack complete information at an appropriate cost."

Researchers from Great Basin Corporation, Denver Health Hospital and the Children's Memorial Hospital in Chicago assessed the sensitivity and specificity of the Staph ID/R test and determined that Staph ID/R has excellent specificity with no non-specific cross-reactivity observed. 

"The use of Staph ID/R could positively affect patient management and laboratory workflow," said Robert Jenison, chief technology officer for Great Basin Corporation and lead author of the study. "A significant advantage of the Staph ID/R test is that it can provide species information that may significantly speed up the diagnosis process, ensuring patients get the right treatment sooner.  Also, nearly one-third of all positive blood cultures are from contamination and this test can identify these cases to remove patients from costly and unnecessary therapeutic interventions."

Great Basin's highly sensitive, easy-to-use, integrated cartridge system allows for more accurate and information-rich detection of infectious diseases, allowing providers to diagnose and define a clear treatment path sooner for improved patient outcomes, shorter hospital stays and significant cost savings. The company's goal is to deliver assays that can be performed in a CLIA-rated waived or moderately complex laboratory at a lower cost than other molecular diagnostic solutions. 

Great Basin's technology entails an integrated disposable cartridge containing all necessary reagents and an inexpensive bench-top analyzer that executes the assay, interprets the results and provides electronic output to the clinician. The platform has several key advantages over other molecular solutions:

Results in less than one hour, depending on the target of interest True sample-to-result with no more than two to three hands-on steps On-demand testing; no batching tests that delay results Multiplexes up to 64 distinct targets in a single assay

In addition to Jenison, the study was authored by Brian Hicke, Chris Pasco, John Dunn, Heidi Jaeckel, Dan Nieuwlandt, and Evelyn Woodruff of Great Basin Corporation; Diane Weed of Denver Health Hospital; and Xiaotian Zheng of Children's Memorial Hospital in Chicago.

In November 2011, the company submitted a 510(k) application to the U.S. Food and Drug Administration (FDA) for its first molecular diagnostic test for Clostridium difficile (C. diff). The company intends to begin clinical trials for the Staph ID/R assay in 2012.

About Great Basin Corporation

Great Basin Corporation is a privately held life sciences company that commercializes breakthrough chip-based technologies for the molecular, rapid diagnostic testing market.  The company is dedicated to the development of simple, yet powerful, sample-to-result technology and products that provide fast, multiple-pathogen diagnoses of infectious diseases. By providing more diagnostic data per sample, healthcare providers are able to treat patients with the right medication sooner, improving outcomes and reducing costs. The company's vision is to make molecular diagnostic testing so simple and cost-effective that every patient will be tested for every serious infection, reducing misdiagnoses and significantly limiting the spread of infectious disease. More information can be found on the company's website at http://www.gbscience.com. 

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Journal of Clinical Microbiology Publishes Study Demonstrating Accuracy and Specificity of Great Basin Corporation's ...

Research and Markets: Emerging Microbiology Tests and Companies Developing New Technologies and Products

DUBLIN--(BUSINESS WIRE)--

Research and Markets (http://www.researchandmarkets.com/research/2920a3/emerging_microbiol) has announced the addition of the "Emerging Microbiology Tests and Companies Developing New Technologies and Products" report to their offering.

This 650-page report provides a comprehensive marketing and technological assessment, as well as medical rationale and diagnostic prospects for nearly 80 infectious diseases and viruses, including their scientific background, clinical significance and market needs for both current and emerging tests, vaccines, drugs and extensive listings of companies developing or marketing new technologies and products.

The report contains 650 pages and 47 tables.

Key Topics Covered:

1. AIDS

2. Adenovirus

3. Aeromonas

4. Anthrax/Bacillus Anthracis

5. Arboviruses

6. Babesiosis

7. Bacillary Epithelioid Angiomatosis (BEA) And Other Bartonella (Rochalimaea)

8. Blastocystis Hominis

9. Brucella

10. Campylobacter

11. Candida

12. Chagas Disease

13. Chancroid

14. Chlamydia

15. Clostridium Difficile

16. Coronaviruses

17. Coxsackieviruses

18. Creutzfeldt-Jakob's Disease

19. Cryptosporidium Parvum

20. Cyclospora Cayetanensis

21. Cytomegalovirus

22. Ebola Virus

23. E. Coli

24. EchoVirus

25. Encephalitis

26. Enteroviruses

27. Epstein-Barr Virus

28. Giardia Lamblia

29. Gonorrhea

30. Granuloma Inguinale

31. Hantavirus

32. Helicobacter Pylori

33. Hepatitis

34. Herpes Simplex Virus

35. Human Herpes Virus-6 (HHV-6)

36. Influenza Viruses

37. Legionella

38. Lyme Disease

39. Lymphogranuloma Venereum (LGV)

40. Malaria

41. Measles (Rubeola)

42. Meningitis

43. Microsporidium

44. Mononucleosis

45. Mumps

46. Mycoplasma

47. Papillomaviruses

48. Parvovirus B19

49. Pneumonia

50. Polyomaviruses

51. Pseudomonas Aeruginosa

52. Rabies

53. Respiratory Syncytial Virus (RSV)

54. RhinoViruses

55. RotaVirus (REOVIRUS)

56. Rubella(MEASLES)

57. Salmonellosis

58. Septicemia

59. Shigellosis

60. Staphylococcus Aureus

61. Streptococci

62. Syphilis

63. Toxoplasmosis

64. Trichomonas Vaginalis

65. Tuberculosis

66. Vibrio

67. West Nile Virus

68. Yersina

For more information visit http://www.researchandmarkets.com/research/2920a3/emerging_microbiol

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Research and Markets: Emerging Microbiology Tests and Companies Developing New Technologies and Products