Creative Edge Nutrition, Inc. Signs Distribution Deal

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ORLANDO, FL--(Marketwire -05/29/12)- Creative Edge Nutrition, Inc. (FITX.PK), a nutritional supplement company focusing on active lifestyles, announced today that it has signed a distribution deal with Fitness One, a leading online e-commerce site. Fitness One is a direct to consumer and a national and international supplement distribution company based in Michigan.

Science Defined Nutrition (SDN) and Cenergy will be one of the featured supplement lines in the Fitness One product offering. Fitness One represents other top nutrition manufacturers in the industry.

Bill Chaaban, Cenergy's CEO and Founder of Fitness One, stated, "We will be very strategic in our online and retail distribution partnerships. Our strategy is to identify companies that will focus on online marketing strategies and brand development. The demand for new innovative products will drive the SDN and Cenergy line of products in the U.S., and internationally through this online distribution presence and partnership with Fitness One. We will continue to aggressively grow and expand our presence in the sports nutrition marketplace through both organic growth and strategic acquisitions."

Jeff Thomas, Vice President of Distributor Relation and Brand Management, commented, "This was obviously one of the first distribution deals that we wanted to do as Fitness One have a major online presence and it is important that SDN and Cenergy establish its ecommerce product offerings to clients worldwide. This is the first of many distribution deals we will be announcing both in the retail and internet market expansion."

About Fitness One, Inc.Fitness One is a performance nutrition superstore, and a leading online e-commerce and worldwide distribution company and direct to consumer, specializing in nutritional supplements, vitamins, and other health products. http://www.fitnessone.com

About Creative Edge Nutrition, Inc. Creative Edge Nutrition is a holding company and a Nutritional Supplement Company focused on developing innovative, high quality supplements. The company offers a broad spectrum of capsules, tablets, and powders, as well as science-based products in the principal categories of weight management, nutrition challenges, energy and fitness. The Company manufactures under strict GMP guidelines at GMP Certified and/or FDA registered facilities. http://www.CenergyNutrition.com and http://www.facebook.com/pages/Creative-Edge-Nutrition-Inc/115224738609211

Safe Harbor Notice This press release may contain "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995, such as statements relating to financial results and plans for future development activities, and are thus prospective. Forward-looking statements include all statements that are not statements of historical fact regarding intent, belief or current expectations of the Company, its directors or its officers. Investors are cautioned that any such forward-looking statements are not guarantees of future performance and involve risks and uncertainties, many of which are beyond the Company's ability to control. Actual results may differ materially from those projected in the forward-looking statements. Among the factors that could cause actual results to differ materially from those indicated in the forward-looking statements are risks and uncertainties associated with the Company's business and finances in general, including the ability to continue and manage its growth, competition, global economic conditions and other factors discussed in detail in the Company's periodic filings with the Security and Exchange Commission. The Company undertakes no obligation to update any forward-looking statements.

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Creative Edge Nutrition, Inc. Signs Distribution Deal

Newcastle University experts get £5m synthetic biology grant

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RESEARCHERS in the North East have been awarded a multi-million pound grant to develop new technology which could lead to breakthroughs for healthcare and the environment.

Experts at Newcastle University are playing a leading role in the new project, which has just secured almost 5m from the Engineering and Physical Sciences Research Council (EPSRC).

The academics are looking to develop new technology in the emerging field of synthetic biology, with support from research teams at Imperial and Kings Colleges London, plus Cambridge and Edinburgh Universities.

Professor Anil Wipat, from the universitys school of computing science, is leading Newcastles side of the project.

He said: This work builds on ongoing cutting-edge work in the application of computing principles and technology to the design of novel, commercially valuable biological systems.

This is an unrivalled opportunity to develop the infrastructure necessary to produce new and useful innovations for medicine, agriculture and the environment.

The application of synthetic biology will both replace existing inefficient production processes and speed up the development of new processes and products for a wide range of industrial sectors, including chemical, biofuels and healthcare industries.

Newcastle University will play a major role in the project, leading the computational design and the development of industrially relevant bacterial strains. Announcing the grant, Science and Technology Minister David Willetts said: Synthetic biology could provide solutions to many of humanitys most pressing issues and at the same time presents significant growth opportunities.

This investment will lay the groundwork for the commercialisation of research, ensuring academics and industry can realise the full potential of this exciting area of science.

Another goal of the project is to create a UK infrastructure for synthetic biology that will be widely available to universities throughout the UK and beyond.

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Leading RNA biologist René Ketting joins the Institute of Molecular Biology as Scientific Director

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29.05.2012 - (idw) Johannes Gutenberg-Universitt Mainz

Ketting will introduce C. elegans and the zebrafish as model systems at IMB to study mechanisms controlling development and disease The Institute of Molecular Biology (IMB) appoints Professor Ren Ketting as its second Scientific Director. Ketting is a leading molecular biologist who will be focusing on the biology of non-coding RNAs. He will introduce C. elegans and the zebrafish as model systems at IMB to study mechanisms controlling development and disease.

For decades, RNAs have only been seen as intermediates in the production of proteins. However, the discovery of new classes of RNA which control the activity of genes has dramatically changed our view of these molecules. Professor Ren Ketting is one of the pioneers of this exciting, emerging area. His research focuses on so-called non-coding RNA (ncRNA), which he, with others, has shown to play a key role in embryonic development. Furthermore, errors in the control of gene activity by ncRNAs contribute to major diseases, such as cancer and heart failure.

Specifically, Ketting investigates three central aspects of ncRNA biology: (i) how certain ncRNAs are able to silence the expression of specific genes, (ii) how ncRNAs regulate the activity of genes by triggering changes to chromatin, i.e., the way the DNA is packaged, and (iii) how they act to stop transposons, short pieces of DNA that can jump within the genome, from moving. The movement of transposons has a major impact on the stability of our genetic material. Understanding how ncRNAs prevent such movement therefore provides important insights into how our genomes are maintained in a healthy state.

IMB's Founding Director, Professor Christof Niehrs, is enthusiastic about Ren Ketting joining IMB: "Ren's research perfectly complements the work already carried out at IMB. His recruitment significantly bolsters the IMB's expertise and international visibility in the field of RNA biology and will lead to many exciting collaborations." In addition to becoming a Director at IMB, Ketting has also been appointed as Professor within the Faculty of Biology at Johannes Gutenberg University Mainz (JGU). "We are very glad to have succeeded in recruiting Professor Ren Ketting. His appointment brings an internationally renowned scientist to Mainz and further strengthens biological research at Mainz University," states Professor Georg Krausch, President of JGU.

"Professor Ketting's appointment marks another important step in establishing IMB as an international beacon of research in the life sciences. We are very happy that IMB could attract a scientist of such caliber from abroad and are confident that the search for a further scientific director will be equally successful", says Otto Boehringer, chairman of the Boehringer Ingelheim Foundation. To mark the 125th anniversary of the company Boehringer Ingelheim in 2010, the foundation pledged itself to donate 100 million for the scientific running of IMB.

The Institute for Molecular Biology gGmbH (IMB) The Institute of Molecular Biology gGmbH (IMB) is a new center of excellence in the life sciences. It was established in March 2011. Research at IMB concentrates on three cutting-edge areas: epigenetics, developmental biology, and DNA repair. The institute is a prime example of a successful collaboration between public authorities and a private foundation. The Boehringer Ingelheim Foundation has dedicated 100 million for a period of 10 years to cover the operating costs for research at IMB, while the state of Rhineland-Palatinate provided approximately 50 million for the construction of a state-of-the-art building

The Boehringer Ingelheim Foundation The Boehringer Ingelheim Foundation is an independent, non-profit organization committed to the promotion of the medical, biological, chemical, and pharmaceutical sciences. It was established in 1977 by Hubertus Liebrecht, a member of the shareholder family of the company Boehringer Ingelheim. jQuery(document).ready(function($) { $("fb_share").attr("share_url") = encodeURIComponent(window.location); });

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Leading RNA biologist René Ketting joins the Institute of Molecular Biology as Scientific Director

Makati Medical Center now offering stem cell therapy

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THE MAKATI Medical Centers Cancer Center celebrated its first year anniversary and marked the occasion with the launch of its Cellular Therapeutics Laboratory. Present at the ribbon-cutting ceremony were Dr. Eric Flores, head, Spine Clinic and Stem Cell Lab; Rosalie Montenegro, Makati Medical Center president and CEO; Dr. ManuelO. Fernandez Jr., executive vice president and director, Professional Services; Dr. Remedios G. Suntay, director and treasurer, MDI Board; Dr. Benjamin N. Alimurung, medical director; Dr. Francis Chung, scientific officer, Stem Cell Lab; and Augusto P. Palisoc Jr., executive director, president and CEO, MPIC Hospital Group.

MAKATIMEDS Cellular Therapeutics Laboratory is managed by experienced scientists with extensive training and is affiliated with the International Society for Cellular Therapy.

Stem cell therapy is now being offered at Makati Medical Center (MMC) as potential cure for a wide range of illnesses, from various types of cancer and heart ailments to incurable diseases such as multiple sclerosis, Parkinsons and Alzheimers.

Stem cell therapy is believed to be effective in bone marrow transplant for leukemia patients, and with early intervention, yields desirable results among renal and prostate cancer patients.

Launched in the first year anniversary of the hospitals cancer center, MMCs Cellular Therapeutics Laboratory is equipped with technology touted to be totally unmatched in our country, says Dr. Francis Chung, scientific officer of the lab. No system exists elsewhere.

Employing the strictest sterility standards at par with that of the US Food and Drug Administration, the lab has state-of-the-art facilities. The Clinimacs CD34 Reagent System is a machine that isolates specific cells needed for the procedure, while the Flow Cytomer ensures the purity of cultured cells.

Transplantation

Sourcing the stem cells, however, is what truly sets the Philippines premier health institution apart from chi-chi spas that also push stem cell therapy for beauty and anti-aging procedures.

At MMC, healthy stem cells are acquired from the patients themselves, a process known as autologous transplantation. For those suffering from an ailment, a parent, sibling or other close relative could be the donor. The hospital strives for utmost compatibility between patient and donor through a 10-point DNA matching system.

If a battery of tests finds a patient to be up to it, medication is given to prepare him for stem cell harvest.

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Makati Medical Center now offering stem cell therapy

Hypnosis and Yoga Open Hidden Spiritual Doors

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May 28, 2012|9:22 am

Altered states of consciousness and other mystical practices open doors in the spiritual realm. Once a door is opened, a person becomes vulnerable to any spirits which come through that door. For example, a seance opens a door. So do animal sacrifices....and all voodoo rituals as well. Astrology is another spiritual exercise which opens a door. Even something seemingly as innocent as placing a Native American "dreamcatcher" above your bed opens a door in the spiritual realm.

A number of years ago a mother heard me talk about dreamcatchers. She told me that her daughter had been having nightmares every night for years. She immediately removed the dreamcatcher from her daughter's bed. The first night the dreamcatcher came down, the nightmares stopped and never came back. Close the spiritual door and you close off access to unwanted spirits.

Hypnosis is basic to the Eastern religions. Prominent hypnotists have estimated that there are probably over 100 different stages of hypnotic trance. Christians should never allow themselves to be put in a trance....regardless of who is leading you into that mental state of relaxation. No matter what obstacles we face, God will help us if we rely upon Him rather than magical or mystical experiences. It is very dangerous to open hidden spiritual doors through hypnosis.

These doors are "hidden" because they are invisible to the human eye. You also don't see the spirits that come through these doors. Likewise, you don't see the Holy Spirit or Jesus when you trust Christ for salvation. Nevertheless, God enters your heart through a door in the spiritual realm the moment you are converted.

St. Paul asked, "Did you receive the Spirit by observing the law, or by believing what you heard?" (Galatians 3:2) There is only one right answer. The Holy Spirit enters a person's life through the door of Jesus Christ when that person believes the good news of the Gospel.

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Hypnosis operates on the other side of the ledger. As one New Age author put it, "Hypnosis can be an open door to psychic experiences of many kinds." Born again believers should never turn to psychic experiences to help them solve a problem. God is our deliverer and our defense. God is not the author of hypnosis.

Yoga opens hidden spiritual doors as well. The physical exercises of yoga are designed to prepare the body for the spiritual changes which yoga produces. Some of the reported symptoms of a "Kundalini Awakening" through yoga include: itching, burning, cramping, twitching of skin and body, severe emotional mood swings, anxiety, depression, rage, fear and dread, mental confusion, and even paranormal activity. In short, yoga never produces Christ-centered peace and joy. The Holy Spirit uses the Scriptures and our faith in Christ to produce that good fruit....not the mystical practices of Eastern religions.

A person may enter into a seance or hypnosis or yoga with innocent motives. That doesn't solve the problem. When you open a door to spirits, you place yourself in harm's way....unless you are turning to the Holy Spirit. No born again believer should utilize yoga or hypnosis because of the spiritual dangers associated with these practices. Even when facilitated by a "professional," the dangers far outweigh any potential benefits.

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Hypnosis and Yoga Open Hidden Spiritual Doors

Jerry Remy, Don Orsillo React Very Differently as Foul Ball Heads Towards NESN Booth (Animation)

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Jerry Remy and Don Orsillo both do a great job in the booth broadcasting Red Sox games on NESN, but when it comes to catching foul balls, it appears that one of them has some room for improvement. During Sunday's game against the Tampa Bay Rays, Scott Podsednik sent a foul ball towards the NESN booth, causing a couple of differing reactions from the broadcasters. Remy, the former ballplayer ...

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Jerry Remy, Don Orsillo React Very Differently as Foul Ball Heads Towards NESN Booth (Animation)

Kruger and Kylie wow as Cannes closes

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German actress and jury member Kruger poses as she arrives for the closing ceremony. Photo: AFP

Diane Kruger wowed with an unusual gown at the Cannes Film Festival closing ceremony.

The actress pushed the boat out in the style stakes as she took to the red carpet in a voluminous Christian Dior Couture creation on Sunday.

The festival juror looked quite regal in a full-skirted floor-sweeper made from sheer white material with a checked pattern and grey patches.

The blonde actress teamed the magnificent confection from the designer's Spring/Summer 2012 collection with a pair of diamond earrings and smoky eyes.

Kruger later changed into a more practical Jenny Packham dress for the Cannes Winners Dinner.

The slim monochrome design featured a sheer long-sleeved top with a strategically placed panel across the bust and pearl embellishment before falling into a sleek black skirt.

The star accessorised the elegant frock with a gorgeous clutch made from light wood and mother of pearl.

Pop sensation Kylie Minogue also walked the red carpet on the French Riviera on Sunday.

The Australian singer looked stunning in a pale blue gown with sparkly embellishments. The star teamed the flowing frock with a beautiful diamond necklace and towering metallic sandals.

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NASA's Apollo Landing Sites Will Be Protected

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Last week, the Google Lunar X Prize Foundation announced that it will recognize the guidelines NASA has established to protect historic sites on the moon.

For the 26 teams currently vying for prize, this means their attempts to land on and rove around the moon have to stay clear of the Apollo landing sites. After all, its not just technological relics that rest on the surface; there's a human record tied into those sites, too.

NEWS: Genetically Altered Astronaut Poo? NASA Wants to Know

The Apollo landing zones are incredibly unique. On Earth, preserving an historic site usually comes with a multimillion dollar price tag to cover ongoing maintenance. But on the moon, where theres no weather to wear theses sites away, preserving them is as simple as never going near them.

Neil Armstrongs boot prints will never fade. Theres also science at those site that ought to be left alone; bacteria in fecal collection bags could be of interest to future biologists.

But theres more than just waste, spent descent stages, and lunar rovers in six areas on the moons surface. There are personal effects that humanize the missions, the program on the whole, and tell the stories of the individuals who walked on the surface.

Armstrong and Buzz Aldrin, whose Apollo 11 mission patch didnt list theirs and Michael Collins names, brought another crews insignia to the surface. After their two and a half hour EVA, the crew left an Apollo 1 patch bearing the names of the three astronauts who died in the pre-launch fire in 1967. It joined the American flag and official mission plaque as permanent fixtures at the Sea of Tranquility.

PHOTOS: Apollo 18: Myths of the Moon Missions

Apollo 12 also paid tribute to a fallen colleague. Clifton Curtis Williams was in line to serve as lunar module pilot on the lunar flight when he was killed when his T-38 jet entered a fatal spin and crashed. The crews commander Pete Conrad brought Alan Bean into the crew to take Williams place. Suddenly making the jump from rookie to moonwalker, Bean paid tribute to Williams by adding a fourth star to the crews mission patch. He also took Williams naval aviator wings of gold pin to the moon and laid it to rest on the Ocean of Storms. Beans own silver astronaut pin is up there too inside the Surveyor crater. He wouldnt need it after the mission since it would be replaced with a gold one, and couldnt think of a better place to leave it.

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NASA releases NASA App 2.0 for iPhone, iPod touch

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William Atkins Tuesday, 29 May 2012 04:08

Science - Space

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NASA announced on May 21, 2012, that it has released an updated version of its free NASA App for iPhone and iPod touch, which includes several new features and a redesigned interface to make it better for its millions of users.

NASA states, The NASA App 2.0 includes several new features and a completely redesigned user interface that improves the way people can explore and experience NASA content on their mobile devices.

The App was designed by a NASA team at the Ames Reseach Center (Moffett Field, California).

The 4.7 million people who have so far downloaded the App should see a much faster and more intuitive interface for the updated version.

NASA states, Other new features of NASA App 2.0 include weather forecasts in the spacecraft sighting opportunities section; maps, information and links to all of the NASA visitor centers; a section about NASA's programs, as well as the ability to print, save and access favorite items, and bookmark images.

However, the NASA App 2.0 requires iOS 5.0 or later.

Page two concludes with further information on the free new App from NASA, along where you can go to download it to your mobile device.

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NASA releases NASA App 2.0 for iPhone, iPod touch

NASA Wanted Astronauts to View Venus Up-Close

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In a little over a week, were all going to be looking skyward and focusing our sights (safely) on Venus as it crosses the disk of the sun. It's going to be a fantastic view, especially since most of us only ever see Venus as a tiny dot of light in the sky. But in 1967, NASA considered giving three astronauts a really rare view of Venus by sending them on a flyby around the second planet from the sun.

The mission was developed under the Apollo Applications Program (AAP) that was designed to build on and apply Apollo-era technology to greater goals in space. Out of the AAP NASA hoped to see Earth orbiting laboratories, research stations on the moon, and manned interplanetary missions. In 1967, this was Americas future in space.

PHOTOS: The Gemini Missions: Paving the Path for Apollo

One of the interplanetary targets was Venus. After visiting the planet with the unmanned Mariner 2 spacecraft in 1962, NASA learned that the planet lacks a strong magnetic field, has an extremely hot surface generated in the lower atmosphere or surface, and that the cosmic radiation in the interplanetary space was survivable. NASA also learned that it was worth going back. There was undoubtedly more to Venus locked under its thick cloud cover.

To get a crew there, NASA would use a revised Apollo spacecraft. Like the lunar missions, it was a tripartite design composed of a Command and Service Module (CSM), and Environmental Support Module (ESM), and a third habitable section. Heres how the mission was designed to play out.

A three-man crew, nestled in the CM, would launch on a Saturn V. The CSM would perform the same functions it did during the Apollo lunar missions: its onboard computer would serve as the primary guidance and navigation system, provide the main reaction control, and act as the principle telemetry and communications link with mission control. Really, the mission would be a simple of matter of engineers rewriting the computers commands to send the crew to Venus instead of the moon. The hard part is keeping them alive and well during the 400 day mission. This is where the other modules come into play.

ANALYSIS: NASA's Bold 'Plan X' Changed Spaceflight History

With no purpose for a Lunar Module on a Venus flyby, the spidery spacecraft would be swapped out for the larger ESM. Once in Earth orbit, the crew would separate the CSM from the rest of the spacecraft, turn around, and dock with the ESM. Then they could open the hatch and transfer between the vehicles. The ESM was designed as the principle experiment bay on the mission and would provide long term life support and environmental control to the whole spacecraft configuration.

With the CSM and ESM docked, the Saturn Vs upper SIV-B stage would fire and send the whole thing towards Venus. But instead of jettisoning the spent rocket stage, the crew would re-purpose it -- neither of the other two module gave them a comfortable living space. In the ESM the astronauts would have everything theyd need to refurbish the rocket stage and turn it into their main habitable module and recreational space. Solar panels lining the outside would provide power to the whole spacecraft.

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Anarchists attack science

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Investigations of the shooting of nuclear-engineering head Roberto Adinolfi have confirmed the involvement of an eco-anarchist group.

P. RATTINI/AFP/GETTY

A loose coalition of eco-anarchist groups is increasingly launching violent attacks on scientists.

A group calling itself the Olga Cell of the Informal Anarchist Federation International Revolutionary Front has claimed responsibility for the non-fatal shooting of a nuclear-engineering executive on 7May in Genoa, Italy. The same group sent a letter bomb to a Swiss pro-nuclear lobby group in 2011; attempted to bomb IBMs nanotechnology laboratory in Switzerland in 2010; and has ties with a group responsible for at least four bomb attacks on nanotechnology facilities in Mexico. Security authorities say that such eco-anarchist groups are forging stronger links.

On 11May, the cell sent a four-page letter to the Italian newspaper Corriere della Sera claiming responsibility for the shooting of Roberto Adinolfi, the chief executive of Ansaldo Nucleare, the nuclear-engineering subsidiary of aerospace and defence giant Finmeccanica. Believed by authorities to be genuine, the letter is riddled with anti-science rhetoric. The group targeted Adinolfi because he is a sorcerer of the atom, it wrote. Adinolfi knows well that it is only a matter of time before a European Fukushima kills on our continent.

Science in centuries past promised us a golden age, but it is pushing us towards self-destruction and total slavery, the letter continues. With this action of ours, we return to you a tiny part of the suffering that you, man of science, are pouring into this world. The group also threatened to carry out further attacks.

The Italian Ministry of the Interior has subsequently beefed up security at thousands of potential political, industrial and scientific targets. The measures include assigning bodyguards to 550 individuals.

The Olga Cell, named after an imprisoned Greek anarchist, is part of the Informal Anarchist Federation, which, in April 2011, claimed responsibility for sending a parcel bomb that exploded at the offices of the Swiss nuclear lobby group, Swissnuclear, in Olten. A letter found in the remains of the bomb demanded the release of three individuals who had been detained for plotting an attack on IBMs flagship nanotechnology facility in Zurich earlier that year. In a situation report published this month, the Swiss Federal Intelligence Service explicitly linked the federation to the IBM attack.

The Informal Anarchist Federation argues that technology, and indeed civilization, is responsible for the worlds ills, and that scientists are the handmaidens of capitalism. Finmeccanica means bio- and nanotechnology. Finmeccanica means death and suffering, new frontiers of Italian capitalism, the letter reads.

The cell says that it is uniting with eco-anarchist groups in other countries, including Mexico, Chile, Greece and the United Kingdom. Mexico has already seen similar attacks: in August 2011, a group called Individuals Tending Towards Savagery sent a parcel bomb that wounded two nanotechnology researchers at the Monterrey Institute of Technology. One received burns to his legs and a perforated eardrum and the other had his lung pierced by shrapnel (G. Herrera Corral Nature 476,373; 2011). The package contained enough explosive to collapse part of the building, according to police, but failed to detonate properly.

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Bless U – Video

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28-05-2012 03:00 Here is a blessing. Bless you. Bless your heart. By the way when I stared (store?) into the camera at the end I could see you and do you know what? You DO look wonderful! I love you. Also my GOODNESS I look so SCRUFFY in this video. I will endeavour to be less scruffy in the next video. And I'll turn on the god damn light in the background, too, so it doesn't look like I'm operating out of a friggin' dungeon! Jeez louise! I don't mind so much. If you don't love me at my scruffiest, you don't deserve me at my scrubbed-uppiest! Am I RIGHT!!!!!!!!!!!!!!!!!!!!! I was gonna keep hitting ! until the video uploaded but then I realised it wasn't QUITE as uploaded as I th- oh! Now it's uploaded. It'll be live at according to the thingy. Good! ALSO edit after upload: I used the youtube lighting auto-fix and now this has got ****super dramatic lighting**** pretend it is an action film! W- was that an explosion in the background?! YES

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Bless U - Video

BryCraft Server- E001: Mob Madness(Re-Upload) – Video

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28-05-2012 10:12 Channels/People included in this video: A Minecraft server set up to be completely legit and have no signs of griefing. The server is called the BryCraft server intended for Youtubers that want a legit server to play on and only have the intentions of playing Legitimately. We set up this server to create a network of different Youtubers all in contact and all working togeather to vreate new videos with unique features. The BryCraft server is: (Recruiting)

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BryCraft Server- E001: Mob Madness(Re-Upload) - Video

Swedish researchers discovery promises unique medicine for treatment of chronic and diabetic wounds

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28.05.2012 - (idw) Schwedischer Forschungsrat - The Swedish Research Council

A unique new medicine that can start and hasten healing of diabetic and other chronic sores is being developed at Ume University in Sweden. After several years of successful experimental research, it is now ready for clinical testing. Behind this new medicine is a group of researchers at the Department of Medical Chemistry and Biophysics who have made the unique finding that the protein plasminogen is a regulator that initiates and hastens wound healing by triggering the inflammatory reaction. Their discovery is now being published in the highly ranked journal Blood.

Today we have the knowledge needed to develop a medicine, says Professor Tor Ny, one of the authors of the article. The bulk of the preclinical research has been completed, and we have been in contact with the Medical Products Agency to discuss a program for clinical testing.

Plasminogen is a well-known plasma protein that is produced in the liver and found in all bodily fluids. The Ume researchers have re-evaluated its role and managed to show that the concentration of plasminogen increases dramatically in and around wounds, which is an important signal to start the inflammatory reaction required for healing. In diabetic sores the level of plasminogen does not rise in the same way, and this seems to be the reason why these sores do not heal. In mice and rats the researchers were able to show that the healing process starts immediately when plasminogen is injected into the sore, which then heals fully.

The need for a biological pharmaceutical for treating intractable wounds is pressing indeed. Diabetic sores that heal poorly or not at all are the most severe type of chronic sores, affecting millions of people annually. Many of the roughly 350 million diabetes patients in the world develop foot ulcers, and in 10-15 million cases this ultimately leads to amputation. Todays treatment of diabetic ulcers consists primarily of traditional wound care, with compresses and bandages; there is no effective medication.

The Ume researchers are initially concentrating on diabetic wounds, but the medicine has great potential for working on other types of stubborn sores. This includes damaged eardrums and periodontitis. The new pharmaceutical has moreover been shown to be helpful in combatting antibiotic-resistant bacteria (MRSA).

Reference Yue Shen, Yongzhi Guo, Peter Mikus, Rima Sulniute, Malgorzata Wilczynska, Tor Ny, Jinan Li: Plasminogen is a key proinflammatory regulator that accelerates the healing of acute and diabetic wounds Blood. 2012 May 4. [Epub ahead of print]

For more information, please contact Professor Tor Ny: mobile: +46 (0)73-620 50 65; e-mail tor.ny@medchem.umu.se jQuery(document).ready(function($) { $("fb_share").attr("share_url") = encodeURIComponent(window.location); });

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Swedish researchers discovery promises unique medicine for treatment of chronic and diabetic wounds

Discovery promises unique medicine for treatment of chronic and diabetic wounds

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ScienceDaily (May 28, 2012) A unique new medicine that can start and accelerate healing of diabetic and other chronic wounds is being developed at Ume University in Sweden. After several years of successful experimental research, it is now ready for clinical testing.

Behind this new medicine is a group of researchers at the Department of Medical Chemistry and Biophysics who have made the unique finding that the protein plasminogen is a key-regulator that initiates and accelerates wound healing by triggering the inflammatory reaction. Their discovery is now being published in the journal Blood.

Today we have the knowledge needed to develop a medicine, says Professor Tor Ny, one of the authors of the article. The bulk of the preclinical research has been completed, and we have had meetings with the Medical Product Agency to discuss a program for clinical testing.

Plasminogen is a well-known plasma protein that is produced in the liver and found in all bodily fluids. The Ume researchers have now re-assessed its role and managed to show that the concentration of plasminogen increases dramatically in and around wounds, which is an important signal to start the inflammatory reaction required for healing. In diabetic wounds the level of plasminogen does not increase in the same way, and this seems to be the reason why these wounds do not heal. In diabetic mice and rats the researchers were able to show that the healing process starts immediately when plasminogen is injected around the wound, which then heals fully.

A cell line for producing plasminogen on a larger scale has also been developed, and the goal is to start clinical testing as soon as funding can be arranged. The researchers have high hopes, as plasminogen is an endogenous protein that can be assumed not to produce side effects.

The need for a biologics for treating chronic wounds is urgent. Diabetic wounds that do not heal are the most severe type of chronic wounds, affecting millions of people annually. Many of the roughly 350 million diabetes patients in the world develop foot ulcers, and in 10-15 million cases this ultimately leads to amputation. Todays treatment of diabetic wounds consists primarily of traditional wound care, with compresses and bandages; there is no effective medication.

The Ume researchers are initially concentrating on diabetic wounds, but plasminogen also has great potential for working on other types of wounds. This includes tympanic membrane perforations and periodontitis. Being a pro-inflammatory activator, plasminogen has moreover been shown to be effective in combating antibiotic-resistant bacteria (MRSA).

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Bossier Chamber urges funding for LSU Medical School

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The Bossier Chamber of Commerce is speaking out against proposed budget cuts to the LSU Health Shreveport School of Medicine. The group is urging members to write to lawmakers asking that they restore $25 million in proposed cuts. Click here to view the email.

The cuts are part of House Bill 1, which goes to the Senate floor this week. If the proposed cuts are approved, officials say the hospital would eventually collapse.

With 6,000 employees, the hospital is Shreveport-Bossier's largest employer and generates about $773 million annually in economic development in the community.

The LSU Health Shreveport School of Medicine treats approximately 400,000 patients a year and produces 70 percent of the doctors who practice medicine in Louisiana.

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How to get economy growing

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A worker builds a Ford Focus at the Ford Motor Co.'s Michigan Assembly Plant December 14, 2011 in Wayne, Michigan.

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Editor's note: Jeffrey Miron is senior lecturer and director of undergraduate studies in the economics department at Harvard University and a senior fellow at the Cato Institute. Miron is the author of "Libertarianism, from A to Z."

Cambridge, Massachusetts (CNN) -- In a recent discussion of what his administration might accomplish, Mitt Romney claimed that "by virtue of the policies that we put in place, we'd get the unemployment rate down to 6%, and perhaps a little lower," over a period of four years.

Is this goal attainable?

It is. Indeed, it is not that tough a task. If the United States avoids new growth-retarding policies, such as the tax hikes scheduled for January 1, the economy's natural adjustments will lower unemployment substantially. These include downward adjustments in wages, reallocation of job-seekers from slower to faster growing sectors and regions, reduced in-migration plus increased out-migration, and withdrawals from the labor force.

Jeffrey Miron

These adjustments do not always work quickly or for everyone (not every former construction worker can become a computer technician). But history suggests the adjustments do occur, as they have since the recession began. Over the next four years, they will continue to lower the unemployment rate, if not to 6%, at least near that territory.

The more important task for either presidential candidate is restoring the economy to its prerecession growth path. Real GDP has historically grown about 3% per year, and major downturns have been followed by strong recoveries. Within two to three years, therefore, output is typically "back where it would have been."

In this recession, the rapid recovery phase has so far been absent; real GDP is still well below where one would have predicted pre-2008, and with average growth under 3% since the recession ended, the gap grows larger every quarter.

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How to get economy growing