Washington, July 9 (ANI): A new gene therapy approach capable of delivering full-length versions of large genes and improving skeletal muscle function may hold new hope for treating dysferlinopathies and other muscular dystrophies, scientists say.
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New gene transfer strategy shows promise to treat muscular dystrophies
DUBLIN--(BUSINESS WIRE)--
Research and Markets (http://www.researchandmarkets.com/research/kxltqj/gene_therapy_marke) has announced the addition of the "Gene Therapy Market to 2018 - Product Development Slowed by Clinical Failures, Close Regulatory Surveillance and High Compliance Standards" report to their offering.
Gene Therapy: the Next Big Step in Cancer Treatments.
The fight against cancer is leading a new movement in gene therapy, as the failure of conventional cancer therapies is fuelling demand for new treatments, according to a new report by healthcare experts GBI Research.
The new report* states that gene therapy technology is still in its nascent stage, and high levels of regulatory surveillance in clinical development is affecting progress. However, the increasing potential of upcoming treatments and shortcomings in traditional therapies is gradually leading to broader acceptance of gene therapy in medicine.
Therapies such as chemotherapy and hormone therapy control the progression of diseases, but are often associated with severe side effects, such as nausea, hair loss and abnormal blood cell counts. Once administered, the drugs induce systemic action throughout the body, and patients often die due to the side effects of treatment rather than the cancer itself. The inability of these conventional therapies to cure diseases has created a significant unmet need in the treatment of cancer, as well as Human Immunodeficiency Virus (HIV), autoimmune diseases, and viral infections.
Targeted therapies such as monoclonal antibodies, stem cell therapies, Ribonucliec Acid (RNA) therapies and gene therapies have initially shown better efficacy and safety profiles compared to chemotherapies.
Gene therapy has several promising drug candidates, which are likely to drive the growth of the gene therapy market if clinical trials are successful. Collategene by AnGes MG, Cardium Therapeutics' Generx, and Vical Incorporation's Allovectin-7 are in development for a wide range of cancer indications, and are expected to compete in the oncology therapeutics market as the market acceptance of gene therapy improves over time.
Companies Mentioned
- ReGenX Biosciences
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Total Knee Replacement system engineered to address the needs of Asian patients now approved in China. Maxx Medical seeking China-based orthopedic medical device distributor partnersPlymouth Meeting, PA (PRWEB) July 09, 2012 Maxx Medical, Pvt. Ltd., a global medical device company, today announced that its award-winning Freedom Total Knee® System ("Freedom Knee") has recently received State Food ...
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Building projects throughout the Caribbean countries have been on the rise since January and the demand for personalized consultations has been answered with Freedom Steel sending their project managers on an island tour through the Caribbean for the month of July. Responding to repeated requests for onsite meeting to discuss building details, Freedom Steel representatives will be available on ...
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Freedom of religion is a right, but more than just the right to attend the church of our choice. It also assures that government does not force anyone to act contrary to their conscience. The Health and Human Services Act violates this right.
Catholics believe that sexuality is a gift, offering us an amazing opportunity to participate in Gods creative power. Use of contraception reduces this beautiful gift to a mere act of pleasure, one in which our human desires and selfishness are deemed more important than the higher order of Gods plan. The HHSA mandates that all insurance policies provide coverage for contraception, forcing the Catholic Church and its affiliates (social services, hospitals, schools/colleges) to act in direct contradiction to their beliefs.
The HHSA would also require the Catholic Church to provide coverage for some abortive services. Worse than being asked to sanction the artificial prevention of a pregnancy, is asking Catholics to sanction the termination of an innocent human life. We believe that from the moment a life begins at conception, no one has the right to take that life except the author of life himself. Pro-choice gives an unborn baby no choice. No Catholic (or person of conscience) can sanction, or pay for, that.
Freedom is intended to foster dignity, not encourage depravity. Whose dignity is fostered by either contraception or abortion? I am a Catholic, proud that my faith teaches that Gods laws supersede those of humans. I applaud our leaders for taking this unpopular, yet unwavering, stand.
In doing so, they are not imposing judgment or beliefs on anyone. Rather they are asking that the standards of the world not be imposed on us. May God give us the grace to continue to show his compassion to individuals, while remaining uncompromising in our principles.
GERRY MacLEOD
Greenville
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WEST PALM BEACH, FL--(Marketwire -07/09/12)- Scott Storick, of Storick and Associates, an office of MetLife, joins the prestigious Chamber of Commerce of the Palm Beaches. Founded in 1913 by local business leaders as the Board of Trade, an association committed to ensuring the continued growth and prosperity of the County. The Chamber of Commerce of the Palm Beaches strives to support projects that lead to a stronger economy and an improved quality of life.
As a unified voice for businesses, the Chamber accomplishes collectively what no one business can do alone, dealing with the many issues that affect the community's quality of life.
"I am excited to be a part of such an amazing group of people," says Storick. "Being new to South Florida, I'm always eager to meet people who are as committed to helping their community as I am and I look forward to a long successful future here."
The Chamber's strength is derived from its diversity and number of members. These members make the Chamber one of the most effective and respected business associations in the state, providing both input and the manpower to see that the needs of area businesses are met by the city, county and state governments.
Scott Storick is managing director of Storick and Associates, an office of MetLife. Storick is a Chairman's level producer with a rapidly growing list of South Florida clients. Storick and Associates specializes in life insurance, retirement planning, and annuity products.
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Chamber of Commerce of the Palm Beaches Welcomes MetLife Producer Scott Storick
Star gazers from across Southern California will be treated to an appearance by Geoff Norkin of the Science Channel's "Meteorite Men" at the annual Southern California Astronomy Exposition to be held Saturday at Oceanside Photo & Telescope.
Norton will display meteorite samples and talk about his experiences searching for meteorites.
Also scheduled to participate in the free day-long event is Stephen Ramsden, director of the Charlie Bates Solar Astronomy Project, a nonprofit group that teaches children about the sun through lectures and telescope observations.
The exposition is scheduled for 10 a.m. to 6 p.m. Saturday at Oceanside Photo & Telescope, 918 Mission Ave.
More information is available at http://www.optscae.com
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Cognitive Code CEO, Leslie Spring, is seeing his world explode, in a good way. Since the emergence of Siri, the world has awoken to the realities of how artificial intelligence will take on a major role in the way we search and organize our lives. Spring, who’s been building his company to provide the tools for an AI-powered space, is now seeing his work in voice/data recognition and computation ...
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FARNBOROUGH, United Kingdom, July 9, 2012 /CNW/ - The Aerospace Industries Association of Canada (AIAC) today released performance results for Canada's aerospace industry in 2011:
"The aerospace industry's performance for 2011 demonstrates the important contribution this sector continues to makes to the Canadian economy," said Jim Quick, President and CEO of AIAC. "The considerable increase in R&D investments reaffirms aerospace's position as one of Canada's largest industrial contributors to research and development."
Over 60 percent of respondents to AIAC's annual survey agreed that there is considerable room for the industry to grow in Canada in coming years, forecasting hiring increases of up to 15% by 2016. AIAC's members have indicated, however, that the changes to the SR&ED tax credit proposed in this year's federal budget may have a significant negative impact on future R&D investment decisions and weaken the aerospace industry's growth.
"2011 was a successful year for Canada's aerospace industry," said Quick. "In a highly competitive global market, we must continue to build on these achievements. The ongoing Aerospace Review will be the cornerstone to maintaining our industry's competitive edge and remain a world leader in this growing high-tech industry."
For more information on the aerospace industry's performance in 2011, please visit http://www.aiac.ca/resources-and-publications/industry-statistics
The AIAC is the national association representing Canada's aerospace manufacturing and services sector. As the world's fifth-largest aerospace industry, Canada's aerospace sector generates than $22 billion and employed 87,000 Canadians. Nearly three quarters of Canadian aerospace products are exported. AIAC represents the interests of 500 aerospace companies across Canada.
Maryse Harvey Vice-President Public Affairs Aerospace Industries Association of Canada 613 760-4562 mharvey@aiac.ca
Kristen VanderHoek Director of Communications Aerospace Industries Association of Canada 613 232-4297 x225 kvanderhoek@aiac.ca
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Canadian Aerospace Industry Posted Increased Revenues, Employment in 2011
FARNBOROUGH, England, July 9, 2012 /PRNewswire/ -- Lockheed Martin (LMT)has signed an agreement authorizing Marshall Aerospace to become the world's first commercial company to install C-130 Center Wing Boxes (CWB). Marshall Aerospace is also the first C-130J Heavy Maintenance Centre (HMC) in the world.
"As we see the C-130J Super Hercules global fleet expanding, and the demand for the C-130J remaining strong, we need to expand our specialized support network around the world," said Jim Grant, Lockheed Martin's vice president for Air Mobility, at today's signing ceremony. "Marshall Aerospace has unique capability in maintenance, repair and overhaul across all variants of the C-130 platform, including the C-130J Super Hercules, and we are proud of our relationship with them that has spanned many decades."
Steve Fitz-Gerald, CEO of Marshall Aerospace, said: "We are delighted and extremely proud of our longstanding relationship with Lockheed Martin. It is an honour to become the world's first commercial Original Equipment Manufacturer-approved servicecentre forC-130J CWB replacement. Together with our existinguniqueC-130J HMC status, the enhancement of CWB replacement approvalwill position usperfectlyfor long termC-130J global fleet sustainment. This is a significant milestone for Marshall, andbuilds on our solid reputation for providing innovative engineering solutions."
Many C-130s around the world can have their service life extended by having the Center Wing Box replaced. As the main load-bearing component of the C-130's airframe, it is this structure that usually determines the overall operational life of the aircraft.
Headquartered in Bethesda, Md., Lockheed Martin is a global security and aerospace company that employs about 123,000 people worldwide and is principally engaged in the research, design, development, manufacture, integration and sustainment of advanced technology systems, products and services. The Corporation's net sales for 2011 were $46.5 billion.
For additional information, visit our websites:http://www.lockheedmartin.com http://www.codeonemagazine.com
About Marshall Aerospace
Marshall Aerospace is the United Kingdom's leading independent aerospace company and is renowned and respected worldwide for its quality of service, engineering excellence, flexibility and reliability. As an independent service provider, the company specialises in the conversion, modification, maintenance and support of military, civil and business aircraft; and its capabilities include engineering design, manufacture and test; and the provision of personnel, training and advice.
Marshall Aerospace holds many type approvals, granted by national and international authorities, airlines, airframe manufacturers and defence agencies, which enable the company to design and certify modifications and perform maintenance on a number of civil and military platforms. The company has one of the largest aerospace engineering teams in the UK - covering all aspects of design, test, certification and support, in civil and military regulatory environments - and is recognised for its innovative solutions and ability to deliver on-time and to-cost.
For further information, please visit http://www.marshallaerospace.com
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LONDON, July 9, 2012 /PRNewswire/ --FARNBOROUGH AIR SHOW --Sikorsky Aerospace Services (SAS) today announced an exclusive sales and distribution agreement with Northrop Grumman Corporation's Italy-based subsidiary, Northrop Grumman Italia (NGI), to equip BLACK HAWK utility aircraft with its NAVEX-12 Air Navigation System. Certified to military standards, the NAVEX-12 provides a lower weight, more reliable, fiber-optic air navigation system for BLACK HAWK utility helicopters. With OEM compatibility, NAVEX-12 will enhance SAS' strategic upgrade program for revitalizing helicopters eventually sold through the U.S. government's Excess Defense Articles (EDA) program. Sikorsky Aerospace Services is the worldwide aftermarket division of Sikorsky Aircraft Corp., a subsidiary of United Technologies Corp. (UTX).
(Photo: http://photos.prnewswire.com/prnh/20120709/NE36779 )
(Logo: http://photos.prnewswire.com/prnh/20080904/NETH086LOGO )
"We are excited to work with NGI and bring new opportunities to the BLACK HAWK market worldwide. This distribution agreement enables us to provide upgraded solutions and effectively manage material obsolescence for UH-60A and UH-60L helicopters," said Frank DiPasquale, SAS Vice President, Sales & Strategic Relationships. "SAS is continually augmenting its upgrade program, and this capability is part of our strategic international focus to increase foreign military sales."
NAVEX-12 is a lightweight Fiber-Optic Gyroscope Attitude Heading Reference System (FOG AHRS) designed as an upgrade solution to replace older mechanical Vertical Gyros compatible with Sikorsky's H-60A and H-60L platforms. Equivalent to the LISA-200 AHRS used by the U.S. Army, the Sikorsky-approved NAVEX -12 system offers both digital and analog interfaces, increased maintainability and improved reliability.
Additionally, this agreement allows SAS to offer the NAVEX-12 for installation on other rotary- and fixed-wing aircraft.
"This new relationship with Sikorsky Aerospace Services is a cornerstone in an ongoing endeavor to expand our presence in the high-technology navigation products sector," said Marco Clochiatti, Managing Director and General Manager of Northrop Grumman Italia. "We will work with SAS to meet the needs of the worldwide military community through superior product performance that offers outstanding reliability and significant total lifecycle cost savings."
Northrop Grumman (NOC) is a leading global security company providing innovative systems, products and solutions in aerospace, electronics, information systems, and technical services to government and commercial customers worldwide. Please visit http://www.northropgrumman.com for more information.
Sikorsky Aerospace Services provides comprehensive support to rotary- and fixed-wing operators around the world. It offers its military and commercial customers a full portfolio of support services, including material distribution, maintenance, overhaul & repair, aircraft modifications and life-cycle support. Sikorsky Aircraft Corp., based in Stratford, Conn., USA, is a world leader in helicopter design, manufacture and service. United Technologies Corp., based in Hartford, Conn., USA, provides a broad range of high-technology products and support services to the aerospace and building systems industries worldwide.
For more information about UTC's presence at the Farnborough Air Show, visit the http://www.utcaero.com Web site.
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WASHINGTON--(BUSINESS WIRE)--
Houlihan Lokey, the international investment bank, today announced that Linda Maxwell has joined the firms Aerospace, Defense and Government (ADG) investment banking group.Ms. Maxwell is based in Washington, D.C. and reports to Anita Antenucci, Senior Managing Director and Head of the ADG Group.
Ms. Maxwell joins following a 12-year career at Jefferies & Company, where she was most recently chief strategist at Jefferies Quarterdeck, the firms Aerospace & Defense Investment Banking Group.In this role, Ms. Maxwell led business strategy for the firms aerospace and defense client base, having led more than 30 transactions involving many of the world's largest aerospace and defense contractors including Boeing, General Dynamics, Lockheed Martin, Northrop Grumman, and Raytheon.Prior to Jefferies, Ms. Maxwell spent more than a decade at Raytheon Company where she held a number of roles across business development, systems engineering, and engineering manufacturing and design. Ms. Maxwell holds both M.S. and B.S. degrees in mechanical engineering from the Massachusetts Institute of Technology as well as an MBA from Harvard Business School.
In addition, Roger Christopher has joined the firms ADG Group.He is also based in Washington, reporting to Ms. Antenucci. Mr. Christopher joins from KPMG Corporate Finance where he was a vice president involved in sellside M&A engagements in the defense sector. Previously, he was a vice president at Stifel, Nicolaus and Co. in the firms Aerospace, Defense and Government Services Investment Banking Group. While at Stifel, he completed more than 15 transactions, including M&A and public and private debt and equity placements. Mr. Christopher holds a B.S. in electrical engineering from The Cooper Union and an MBA from the Darden Graduate School of Business Administration at the University of Virginia.
Having worked with Linda previously, I am excited to be partnering once again with one of the most experienced bankers in the aerospace and defense sector, said Ms. Antenucci. Linda and Roger bolster our 23-person industry group. We are unique in our size, scope and depth of experience. Their breadth of banking and engineering experience will be invaluable to providing the world-class service our clients have come to expect from us.
These appointments follow the March hire of Ryan OToole and June hire of Jeff Lassiter, both in Los Angeles. The team currently has one of the deepest pools of talent in the sector with 23 investment banking professionals globally.
Houlihan Lokeys AerospaceDefenseGovernment (ADG) Group has announced over 36 transactions since 2010 with an aggregate value of more than $5 billion. In 2011, the group was named the No. 1 M&A advisor by Thomson Reuters for all U.S. aerospace, defense and government transactions. Recent transactions include the $1.88 billion sale of SRA International, Inc., for which the team was awarded the Information Technology Deal of the Year from the M&A Advisor; the sale of Heath Tecna to Zodiac Aerospace, S.A.; and the sale of DS3, a subsidiary of EADS North America, among others. The group is hosting its 10th Annual AerospaceDefenseGovernment Conference Opportunities in a Post-Election Environment on November 8, 2012, in Washington, D.C.
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Houlihan Lokey Continues Expansion of Aerospace-Defense-Government Banking Coverage
MIDLAND, Texas, July 9, 2012 /PRNewswire/ --The Midland Development Corporation (MDC) and XCOR Aerospace jointly announced today the establishment of XCOR's new Commercial Space Research and Development Center Headquarters that will be created over the next eighteen (18) months. XCOR manufactures reusable rocket engines for major aerospace prime contractors and is the designer, manufacturer and operator of the Lynx, a winged fully reusable, high performance suborbital space vehicle that is designed to safely carry two persons or scientific experiments to the edge of space and back up to four times per day.
(Photo: http://photos.prnewswire.com/prnh/20120709/LA37055)
"This is a great day for Midland and a huge step forward for the State of Texas. Visionary companies, like XCOR, continue to choose Texas because they know that innovation is fueled by freedom," Gov. Perry said. "Whether on the cutting edge of biotech, communications, commerce or privatized efforts to serve the needs of the next generation of space explorers, you can find Texas at the forefront of the movement."
XCOR will be establishing their new R&D center on the flight line at Midland International Airport (MAF) in a newly renovated 60,000-square-foot hangar, which will include office space and a test facility. The renovation is expected to commence in early 2013, and be completed by the late autumn.
"XCOR will be upgrading an existing hangar at Midland International Airport," stated Marv Esterly, director of airports at MAF. "This new R&D facility has the potential to open the door to even more economic development at our airport and for our community."
"We are pleased to be establishing our R&D Center in Midland, Texas, where the weather, surrounding landscape, the airport, and the local & state government environment are ideally situated for the future growth and the ultimate realization of a fully reusable orbital system," said Andrew Nelson, chief operating officer of XCOR Aerospace. "With future suborbital operational sites on the East and West Coasts of the United States and around the world, plus a manufacturing and test facility geographically separate from our R&D facility, Midland will truly be at the heart of XCOR's innovation engine."
"The decision to establish XCOR's Research and Development Center Headquarters in Midland came after intense competition from other locations," stated Pam Welch, executive director of MDC, "once the technical and operational needs of XCOR were met, the final factors influencing the decision to locate R&D to Midland included the friendly business climate, a predictable regulatory environment, and the State of Texas tort reform initiatives. These factors allowed XCOR to see a long term future happening in Midland."
Laura Roman, MDC chairman, stated "Today we celebrate the economic diversity that XCOR's Research and Development Center Headquarters will bring to Midland along with the $12,000,000 of new payroll and capital investment over the next five years to our community with an estimated average annual wage of over $60,000 per job."
In parallel with the XCOR facility renovation, the City of Midland is applying to the Federal Aviation Administration (FAA) for a Commercial Space Launch Site designation for MAF, an estimated 12 to 18 months process. Upon completion of the licensing process and the hangar renovation, the XCOR presence will begin to ramp up.
The FAA spaceport designation will also be an important economic development tool because of the potential growth in the commercial space sector as NASA relies more on commercial service providers for launch capability and the space tourism market evolves. Marv Esterly, noted, "When our application is approved, the MAF will be the first "Primary Commercial Service Airport" to be granted this designation, and the combination of the two makes Midland attractive to other commercial space companies."
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STILLWATER, Okla. (AP) -- A Belgian aerospace company announced plans Monday to open a plant in Stillwater, creating up to 600 jobs and investing up to $100 million by 2015.
Gov. Mary Fallin made the announcement Monday as she attended the Farnborough International Air Show in the United Kingdom. ASCO Inc. will build in the former MerCruiser manufacturing facility on Perkins Road in Stillwater.
"Oklahoma has one of the strongest aerospace sectors in the U.S., and we are quickly becoming an international destination for the industry," Fallin said. "Today's announcement is one more indication that our commitment to pro-business policies is helping to attract jobs and businesses to the state."
Officials said the company will initially invest $60 million and employ 250 people by 2014. The second phase of development would bring an additional $30 million to $40 million in capital investment and another 350 jobs by 2015.
"Oklahoma was the best location for our facility," ASCO CEO Christian Boas said. "The state is centrally located in North America and has an existing aerospace industry, which is thriving."
The company designs and makes aircraft components and assemblies for Airbus, Boeing, Bombardier and Embraer commercial jets.
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CHATSWORTH, Calif., July 9, 2012 /PRNewswire/ -- Align Aerospace LLC, a global provider of aerospace fasteners, assembly components and supply chain solutions, is pleased to announce that it has received a Boeing Performance Excellence Award (BPEA). The Boeing Company issues the award annually to recognize suppliers who have achieved superior performance. This year, Boeing recognized a total of 529 suppliers who achieved either a Gold or Silver level BPEA. Based on Boeing's metrics for quality and on time delivery, Align Aerospace achieved Silver level status for 2011.
"We have based our business on superior performance and execution and we are honored to once again receive this very important award from Boeing," said Rick Organ, CEO of Align Aerospace. "Boeing is a worldwide leader in the aerospace industry, and we have enjoyed a long and fruitful relationship with them."
Align provides parts to support Boeing commercial and military satellite programs, Boeing Defense C17 and UAV's, and Boeing Commercial 737, 767, 777 and 787 platforms, both direct to Boeing and through subcontractors.
For more information on the Boeing Performance Excellence Award, visit http://www.boeing.com/companyoffices/doingbiz/supplier_portal/bpea.html.
About Align:
Align Aerospace is a leading supplier of hardware and related components to a broad range of aerospace and defense OEMs and their subcontractors throughout the world. Experts in bid-to-buy, JIT, VMI, lean manufacturing and supply chain management, Align has more than 90,000 unique parts in stock from over 2,000 suppliers ready to ship from its warehouses throughout the U.S. and Europe. Between 1998 and 2011, the Company operated as Pentacon, Eurofast SAS, and Anixter Aerospace Hardware. Align began independent operations in August 2011 as a result of the divestiture of the business by Anixter International to Greenbrier Equity Group.
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Align Aerospace Receives Silver Boeing Performance Excellence Award
CORONA, CA--(Marketwire -07/09/12)- CIRCOR Aerospace, a CIRCOR International Company (CIR), has partnered with Aero Precision Industries to sell and distribute its Fluid Controls, Landing Gear and Actuation, and Sylmar facility product lines, with a particular focus on foreign military sales.
Aero Precision's agreement with CIRCOR Aerospace features a global territory, tailored upon product lines and current distribution channels. Aero Precision will continue to increase CIRCOR's established customer connectivity and market presence for specialized fluidic controls legacy components and actuation as well as nose wheel steering actuators and fully-dressed landing gear and components on military platforms such as fighter aircraft and helicopters.
"Our new ally, Aero Precision and their international network will continue to drive our singular purpose for customer satisfaction in CIRCOR Aerospace products, capabilities and value," said Michael Dill, CIRCOR Aerospace Group Vice President.
"Aero Precision has proven ability to present parts and services to the international military aftermarket in the most efficient and strategic manner, and we're excited to begin our partnership with CIRCOR," noted Frank Cowle, Aero Precision President.
About Aero PrecisionAero Precision is a leader in aerospace distribution and services and a premier worldwide stocking distributor of aircraft OEM parts. With 20 years of reliability, quality products and unparalleled customer service, Aero Precision facilitates spare part purchasing, repair coordination and aircraft maintenance program management using a unique logistic support model to source military aircraft solutions for the US Government and over 60 countries. Aero Precision has stocking distribution or Channel Partnerships with Honeywell, Hamilton Sundstrand, Crane Aerospace, Texstars, CEF, Parker, Woodward, and additional strategic OEM partners for various product lines.
For more information on Aero Precision, visit: http://www.aeroprecision.com
About CIRCOR Aerospace Products Group and CIRCOR Aerospace, Inc.
CIRCOR Aerospace Products Group is focused on the design, development, and manufacture of specialty fluidic control, actuation, and aircraft landing gear systems for demanding aerospace and defense applications. CIRCOR Aerospace provides a full range of fluid controls and electro-mechanical controls, actuation systems, manifold assemblies, and complete landing gear systems. CIRCOR Aerospace has business units located in California, Ohio, New York, Paris and Chemill, France, Tangier, Morocco and Suzhou, China.
Parent company CIRCOR International is headquartered in Burlington, Massachusetts and the CIRCOR Aerospace Products group is headquartered in Corona, California.
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CIRCOR Aerospace Signs Distribution Agreement With Aero Precision
WELLINGTON, Fla.--(BUSINESS WIRE)--
B/E Aerospace (BEAV) (the Company), announced today it has commenced an underwritten public offering of $675.0 million aggregate principal amount of its 5.25% senior notes due 2022.
The senior notes are being offered pursuant to a prospectus supplement and an accompanying prospectus filed by the Company as part of a shelf registration statement filed with the Securities and Exchange Commission (the SEC).
The senior notes are an additional issuance of, will be fully fungible with, rank equally with, and form a single series with the Companys $500 million 5.25% Senior Notes due 2022 issued on March 13, 2012, and will have the same CUSIP number.
The Company intends to use the net proceeds of the offering, together with cash on hand, to fund the consideration in its concurrent tender offer and consent solicitation for any and all of its outstanding 8.50% Senior Notes due 2018, including the payment of accrued interest and any applicable consent payment. The Company intends to use any remaining net proceeds from this offering (to the extent less than all of the 8.50% Senior Notes due 2018 are tendered) for other general corporate purposes.
J.P. Morgan Securities LLC, Citigroup Global Markets Inc., Credit Suisse Securities (USA) LLC, Goldman, Sachs & Co. and UBS Securities LLC are acting as joint book-running managers and RBC Capital Markets, LLC and Wells Fargo Securities, LLC are acting as co-managers for the offering.
This news release does not constitute an offer to sell, or a solicitation of an offer to buy, the notes described herein, nor shall there be any sale of these notes in any jurisdiction in which such an offer, solicitation or sale would be unlawful prior to registration or qualification under the securities law of any such jurisdiction.
The offering is being made by means of a prospectus and the related prospectus supplement only. Copies of the prospectus and the related preliminary prospectus supplement can be obtained from J.P. Morgan Securities LLC, 383 Madison Avenue, New York, New York 10179, attention: High Yield Syndicate, (800) 245-8812, HY_syndicate@jpmorgan.com, Citigroup Global Markets Inc., Brooklyn Army Terminal, 140 58th Street, 8th floor, Brooklyn, New York 11220, (877) 858-5407, Credit Suisse Securities (USA) LLC, Attention: Prospectus Department, One Madison Avenue, New York, New York 10010, (800) 221-1037, Goldman, Sachs & Co., Prospectus Department, 200 West Street, New York, New York 10282, telephone (866) 471-2526, facsimile (212) 902-9316, prospectus-ny@ny.email.gs.com, and UBS Securities LLC, Attention: Prospectus Department, 299 Park Avenue, New York, New York 10171, (877) 827-6444, ext. 561 3884.
This news release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Such forward-looking statements involve risks and uncertainties. The Companys actual experience and results may differ materially from the experience and results anticipated in such statements. Factors that might cause such a difference include those discussed in the Companys filings with the SEC, which include the Registration Statement, prospectus and preliminary prospectus supplement related to this offering and its Proxy Statement, Annual Report on Form 10-K, Quarterly Reports on Form 10-Q and Current Reports on Form 8-K. For more information, see the section entitled "Forward-Looking Statements" contained in the Companys Annual Report on Form 10-K and in other filings. The forward-looking statements included in this news release are made only as of the date of this news release and, except as required by federal securities laws, the Company undertakes no obligation to update publicly or revise any forward-looking statements, whether as a result of new information, future events or otherwise.
About B/E Aerospace
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Andre Davis, right, is hugs his father Richard Davis inside the Tamms Correctional Centre. Photo: AP
Andre Davis spent 32 years behind bars as an innocent man before DNA evidence overturned his life sentence. He was only 19 when he was wrongfully convicted of raping and murdering three-year-old Brianna Stickle in 1980.
Now 50, Mr Davis walked out of Tamms super-maximum security prison in Illinois, USA, last Friday into a radically changed world.
I don't think we had the issues they had in America with the vast separation and the vast number of laboratories that were set up over there, and many of them weren't accredited
Had his legal team not requested in 2004 that blood and semen samples be DNA tested, he might never have been freed. The results proved that Davis could not have committed the crime.
One of 42 convicted men in Illinois who were proven innocent after DNA testing, Mr Davis's case reflects a growing trend in the United States. With support from the Innocence Project and other organisations, DNA testing is being used to re-examine cases where prisoners may be innocent.
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Australia has not experienced a similar ratio of wrongful convictions being overturned after DNA testing and is unlikely to do so in the future, according to a senior NSW forensic expert, who asked not to be identified.
Unlike the US, forensic laboratories in Australia are more heavily regulated and testing standards are higher, he said.
"We run an extremely thorough and accurate system in Australia where laboratories became accredited very early on.
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The trials of Andre Davis: how DNA stopped an innocent life being completely stolen
Revamped biology Ph.D. program aims to double admissions
BY ALY BROWN | JULY 09, 2012 6:30 AM
UI Biology Department officials say renovations in the Ph.D. program will better train students for careers in science through collaboration and seminar opportunities.
Josh Weiner, head of the IBIO program and associate professor in the department, said the new program to be implemented in the fall of 2013 will attract students interested in big-picture puzzles in basic biology.
"We are rebooting the grad program," he said. "We compete for students with other institutions and other overlapping UI programs, like the biosciences and interdisciplinary programs. We want to attract the kind of students who are most interested in big issues in basic biology."
Last year, four new students enrolled in the biology Ph.D. program, but Weiner wants to double those admitted. The program has 33 Ph.D. students; Weiner said the program used to house 50 before severe state and Graduate College budget cuts reduced the number.
Weiner said there aren't many departmental graduate programs around anymore, noting many have merged to create interdisciplinary focuses.
A major concentration for IBIO is to encourage collaboration among faculty, students, and various labs in the department.
"There were different 'research areas' in the old biology Ph.D. program," he said. "In IBIO, however, everything is integrated, and while each lab is focused on a smaller set of topics, students will be expected to integrate into the program as a whole."
During the fall semester of their first year, students previously participated in research rotations between three labs for 10 to 11 weeks, but IBIO will allow seven weeks.
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Revamped biology Ph.D. program aims to double admissions
09.07.2012 - (idw) Ruhr-Universitt Bochum
Researchers at the RUB and from Berkeley have used metal complexes to modify peptide hormones. In the Journal of the American Chemical Society, they report for the first time on the three-dimensional structure of the resulting metal-peptide compounds. With this work, we have laid the molecular foundation for the development of better medicines says Prof. Raphael Stoll from the Faculty of Chemistry and Biochemistry at the Ruhr-University. The team examined hormones that influence the sensation of pain and tumour growth. Bochum, 9.7.2012 No. 237
A new avenue to better medicines Selectively modifying hormones and using them as medicinal substances German-American research team produces metal-peptide complexes
Researchers at the RUB and from Berkeley have used metal complexes to modify peptide hormones. In the Journal of the American Chemical Society, they report for the first time on the three-dimensional structure of the resulting metal-peptide compounds. With this work, we have laid the molecular foundation for the development of better medicines says Prof. Raphael Stoll from the Faculty of Chemistry and Biochemistry at the Ruhr-University. The team examined hormones that influence the sensation of pain and tumour growth.
Peptide hormones have many functions in the body
Hormones consisting of amino acids, the peptide hormones, convey bodily sensations such as pain and hunger, but also transmit growth signals. One example of this is insulin, which is important for the control of blood sugar levels. In interaction with specific receptors, the G-protein-coupled receptors, peptide hormones transport their messages to the cells. The hormones can be specifically chemically modified so that their effect changes, for example pain tolerance is lowered, or tumour growth inhibited. The German-Californian group of researchers has now found a new way to modify peptide hormones.
Metal complexes react with various peptide hormones
The first time they used a metal complex, namely, a rhodium compound, which reacts with the amino acid tyrosine. The precious metal rhodium is used as a catalyst in the synthesis of highly complex medicinal substances in the research laboratory as well as in industrial plants. Among other things, the researchers analysed the peptide hormone encephalin, which is important for the sensation of pain, and octreotide. The latter is a synthetic derivative of the growth hormone somatostatin, approved as a medicinal substance and already used in the treatment of certain tumours. The reaction with the metal complex was highly selective. Although the hormones consist of hundreds of atoms, the rhodium compound was always coordinated by the carbon ring of the tyrosine - the phenol ring.
The team also clarified the structure of the resulting metal-peptide complexes. We hope to develop other metal-containing, peptide-like substances by building on these basic studies says Prof. Dr. Nils-Metzler-Nolte of the Chair of Inorganic Chemistry I. These could modulate the effect of naturally occurring peptide hormones and, for example, be used as a novel remedy for pain or cancer. For the project, the Californian colleagues made their knowledge of the special reactivity of the rhodium compound available. The researchers in Bochum contributed their experience with metal-peptides, the corresponding receptors and the structural analysis of biological macromolecules. This again demonstrates that cutting-edge competitive research can only be carried out efficiently within a research association, says Prof. Stoll. The German Research Foundation (SFB 642 and Research Unit 630) and the Research Department for Interfacial Systems Chemistry at RUB supported the work.
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A new avenue to better medicines: metal-peptide complexes