CSULB Professor's Research Shows Collagen Could Treat Cancer

Most people will be diagnosed with cancer at some point in their lives, according to Katarzyna Slowinska, an associate professor of biochemistry at California State University, Long Beach.

But there is some hope, especially with new drug research that works to find better ways to administer cancer-fighting drugs without harmful side affects and the bodys naturally produced collagen could be the answer, Slowinska said.

My research is in bio material and collagen peptides, Slowinska said. (With collagen), it is a functional material. It is very strong and flexible, and we want to use what biology has already developed and use it for a different function.

For the last eight years, Slowinska has taught biochemistry at CSULB and was awarded a four-year $433,500 grant from the National Institute of Healths National Institute of General Medical Sciences to continue research of short, triple helix strands of amino acids, called peptides, to serve as drug nanocarriers.

Before teaching at CSULB, she received her PhD in physical chemistry from University of California, Berkeley, and worked as a research chemist at GE Global Research Center in New York.

Slowinska said she hopes her research can eventually help those taking the widely used chemotherapy drug Paclitaxel which has some major side effects. Her research shows that the drug could be administered using collagen-based materials to carry and release the cancer-fighting drug directly at or inside of tumor cells, she said.

We plan to work on this, Slowinska said. We already know how peptides come out of the gel, but now we have to put the pieces together to find out if it will work.

This therapeutic way to administer chemotherapy drugs keeps the drug from crystalizing in a persons blood, she added, which is a common side effect due to it being water soluble.

We can add functionality to it, Slowinska added. Collagen gel can be injected with a syringe in the proximity of the tumor. You can inject the collagen and design an anchor to control the rate at which the drug is leaking out of the gel.

As people begin living longer lives, their chances of being diagnosed with cancer increases with every year, so the importance of cancer research is tremendous, she added.

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CSULB Professor's Research Shows Collagen Could Treat Cancer

Christopher Danney, MD – Video


Christopher Danney, MD
Christopher M. Danney, MD is a Board Certified Orthopedic Surgeon. Dr. Danney graduated from the University of Texas at Austin with a degree in Biochemistry, while lettering on the University of Texas football team. He earned his Medical Degree at the University of Texas Medical School in Houston, TX. During his Orthopaedic Surgery Residency at Duke University, Dr. Danney provided orthopedic care for the Duke basketball and football teams. He received the William S. Ogden Traveling Fellowship Award for the Outstanding Junior Resident. He volunteers his time as the team physician for Vandegrift High School and the Texas Stars hockey team. He is the President of the Texas Society of Sports Medicine. Dr. Danney has been named by his peers to the Super Doctors Rising Stars® list in 2012. Dr. Danney, a native Texan, grew up in Boerne near San Antonio. He relocated to Austin and the Texas Hill Country with his wife, Melissa. Dr. Danney has two sons and enjoys golfing and traveling.From:TEXASORTHOPEDICSViews:0 0ratingsTime:03:32More inEducation

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Low Carb Diets Good Or Bad Breaking It Down – Video


Low Carb Diets Good Or Bad Breaking It Down
I apologise for making the biochemistry too scaled down and simplistic for the layperson listening to the point where it is actually incorrect to summerize that part near the end of the video "the body has enzymic pathways that allow direct storage of dietary fat as adipose tissue without any need for insulin and any dietary fat that isn #39;t burned for fuel WILL be stored as body fat with the exception of a potentially small amount of it, 10% or less, due to the glycerol back on the end of triglycerides being potentially converted into glucose once the molecule is broken up... even on a deit that is 90% fat calories with nearly zero insulinogenic activity". GLUT4 transport is only part of the processes involved in those enzymic pathways sorry if I created any confusion.From:IceCreamFitnessViews:545 42ratingsTime:15:23More inSports

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Malassezia And The Skin – Video


Malassezia And The Skin
ll4.me Malassezia And The Skin Introduction, Malassezia Yeasts From a Historical Perspective.- Biodiversity, Phylogeny and Ultrastructure.- Epidemiology of Malassezia-Related Skin Diseases.- Physiology and Biochemistry.- Malassezia Species and Immunity: Host-Pathogen Interactions.- Pityriasis Versicolor and Other Malassezia Skin Diseases.- Malassezia Yeasts in Seborrhoeic and Atopic Eczemas.- Malassezia Fungemia, Antifungal Suceptibility Testing and Epidemiology of Nosocomial Infections.- Genomics and Pathophysiology: Dandruff as a Paradigm.- Malassezia Yeasts in Animal Diseases.- Malassezia Database. EAN/ISBN : 9783642036163 Publisher(s): Springer, Berlin Discussed keywords: Haut, Pilz (Medizin) Format: ePub/PDF Author(s): Boekhout, Teun - Guho, Eveline - Mayser, Peter Introduction, Malassezia Yeasts From a Historical Perspective.- Biodiversity, Phylogeny and Ultrastructure.- Epidemiology of Malassezia-Related Skin Diseases.- Physiology and Biochemistry.- MalasseziaFrom:brianbishop980Views:0 0ratingsTime:00:16More inPeople Blogs

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Biology Of Rhodococcus – Video


Biology Of Rhodococcus
ll4.me Biology Of Rhodococcus Volker G rtler and Robert J. Seviour: Systematics of Members of the Genus Rhodococcus; Iain C. Sutcliffe, Alistair K. Brown and Lynn G. Dover: The rhodococcal cell envelope: composition, organisation and biosynthesis; Michael J Larkin, Leonid A Kulakov, Christopher CR Allen: Genomes and Plasmids in Rhodococcus; Hector M. Alvarez: Central metabolism of species of the genus Rhodococcus; Carla CCR de Carvalho: Adaptation of Rhodococcus to organic solvents; Katherine C. Yam, Robert van der Geize, Lindsay D. Eltis: Catabolism of aromatic compounds and steroids by Rhodococcus; Ludmila Martnkov et al.: Catabolism of Nitriles in Rhodococcus; Ting Ma: The Desulfurization pathway in Rhodococcus; Maria S. Kuyukina, Irena B. Ivshina: Application of Rhodococcus in Bioremediation of Contaminated Environments; Hector M. Alvarez, Alexander Steinbchel: Physiology, biochemistry and molecular biology of triacylglycerol accumulation by Rhodococcus; Maria S. Kuyukina, Irena B. Ivshina: Rhodococcus Biosurfactants: Biosynthesis, Properties and Potential Applications; Elisabeth Stes, Marcelle Holsters, and Danny Vereecke: Phytopathogenic strategies of Rhodococcus fascians; Jose A. Vzquez-Boland et al.: Rhodococcus equi and its pathogenic mechanisms. EAN/ISBN : 9783642129377 Publisher(s): Springer, Berlin Discussed keywords: Bakterien, Mikrobiologie Format: ePub/PDF Author(s): Alvarez, Hctor Volker G rtler and Robert J. Seviour: Systematics of Members of the Genus ...From:raymondatherton785Views:1 0ratingsTime:00:15More inPeople Blogs

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Molecular Biology Of Protein Folding, Part A – Video


Molecular Biology Of Protein Folding, Part A
ll4.me Molecular Biology Of Protein Folding, Part A The importance of protein folding has been recognized for many years. It is the underlying etiology in a large number of human diseases and it appears to be a novel method for cellular regulation of the expression of newly translated proteins. These volumes (Parts A B) address this important topic. As a volume in Progress in Nucleic Acid Research and Molecular Biology, this book provides the latest information on the expanding research being conducted on protein folding.Illustrates how ubiquitin domain proteins are an ideal model system for experimental and computational studies of protein folding.Discusses structural wrapping and its importance in the contexts of network centrality, molecular disease, drug discovery and molecular theranostic engineering.Chapters written by international authors in engineering, biochemistry, physics, and computer science. Publisher: Academic Press Illustration: N Language: ENG Title: Molecular Biology of Protein Folding, Part A Pages: 00288 (Encrypted PDF) On Sale: 2008-12-08 SKU-13/ISBN: 9780123745941 Category: Medical : General Category: Science : Life Sciences - Molecular Biology Category: Science : Life Sciences - Biochemistry The importance of protein folding has been recognized for many years. It is the underlying etiology in a large number of human diseases and it appears to be a novel method for cellular regulation of medical, general, science, life sciences, molecular biologyFrom:raymondatherton785Views:0 0ratingsTime:00:15More inPeople Blogs

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Glycogenolysis – Video


Glycogenolysis
http://www.SalmonellaPlace.com This is a tutorial/lecture on Glycogenolysis. We cover some topics important for classes such as Biochemistry, Molecular and Cellular Biology, Introductory Biology, etc. List of topics: - Steps of Glycogenolysis; - Enzymes involved; - Importance of this Glycogen Metabolism process. If you have any questions, don #39;t be shy!! We hope we are able to clarify this topic. Enjoy!From:TheSalmonellaPlaceViews:37 2ratingsTime:15:51More inEducation

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Dialysis – Wiki Article – Video


Dialysis - Wiki Article
This article is about renal dialysis; for the laboratory technique, see dialysis (biochemistry); for treatment for liver failure, see liver dialysis. In medicine dialysis (from Greek dialusis," delta; iota; #940; lambda; upsilon;... Dialysis - Wiki Article - wikiplays.org Original @ http All Information Derived from Wikipedia using Creative Commons License: en.wikipedia.org Author: Anna Frodesiak Image URL: en.wikipedia.org ( Creative Commons ASA 3.0 This work is in the Public Domain. ) Author: Anna Frodesiak Image URL: en.wikipedia.org ( Creative Commons ASA 3.0 ) Author: Unknown Image URL: en.wikipedia.org ( Creative Commons ASA 3.0 ) Author: Image URL: en.wikipedia.org ( Creative Commons ASA 3.0 ) Author: National Kidney and Urologic Diseases Information Clearinghouse, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA Image URL: en.wikipedia.org ( This work is in the Public Domain. )From:WikiPlaysViews:0 0ratingsTime:15:18More inEducation

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UCLA Chemistry


UCLA Chemistry Biochemistry--Interview with Jennifer Harmon
Jennifer Harmon talks about her experience as a graduate student at UCLA Chemistry Biochemistry Department.From:gradoffice ChembiochemViews:3 0ratingsTime:01:20More inEducation

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Dr. Aaron Fletcher ’02, York College Young Alumnus of the Year 2012 – Video


Dr. Aaron Fletcher #39;02, York College Young Alumnus of the Year 2012
Aaron Fletcher was recognized at York College Homecoming 2012 with the Young Alumnus of the Year award on October 13, 2012. Aaron Fletcher, Class of 2002, is an Assistant Professor of Biology at Dallas Baptist University. A dedicated educator, Fletcher #39;s students say that they have been changed by his classes, as they garner a new appreciation for science and God #39;s creation. One former student noted that, "He is a servant leader who puts his students first. He goes above and beyond (to) educate his students." After graduating from YC, Fletcher earned a PhD in biochemistry from Colorado State University. As a graduate student, he received the Outstanding Teaching Assistant and Outstanding Research Graduate Awards from the Department of Biochemistry and Molecular Biology. Following his doctoral studies, he went on to work at University of Texas Southwestern in the Molecular Biology Department as a research scientist in biomedical research. Fletcher has worked as an independent consultant for the biotech/healthcare equity industry for over five years. Currently, he is the CEO and senior analyst of Bios Research, LLC, an independent research firm that provides monthly healthcare research for hedge funds and the investment advisor industry. He is also serving as the chair-elect of the 1600 member Dallas/Fort Worth section of the American Chemical Society. Aaron is married to Holly (Eckstein #39;02). The couple have one daughter, Madeline, and are members of the Brookhaven Church ...From:YorkCollegeNebViews:0 0ratingsTime:04:51More inEducation

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of Charge Carriers in Organic Photovoltaic Devices – Video


of Charge Carriers in Organic Photovoltaic Devices
A plenary talk from SPIE Optics + Photonics 2012. spie.org This presentation discusses an alternative approach to understanding the important charge-generation step that is critical to operation of an organic photovoltaic device. Instead of considering the interface to be a simple interaction between two semiconductors, a molecular model is discussed. The model takes advantage of the many years of studying photo-induced electron transfer in model donor-acceptor systems, where the process of long-lived charge separation and inhibited recombination process are well known and can be described by a Marcus Formulation. A number of polymer:fullerene systems have been studied, each with differing Gibbs energy driving forces and reorganization energies for electron transfer. The talk examines implications of the findings on improving device performance. Garry Rumbles is a Research Fellow at the US DOE National Renewable Energy Laboratory (NREL). He joined NREL in 2000 and is widely recognized for his research in photochemistry and photophysics of conjugated molecular systems, energy conversion in organic light emitting diodes and organic photovoltaic devices, and nanoscale morphology. He is a Professor Adjoint in the Department of Chemistry and Biochemistry at CU Boulder; and in 2009 he became a Fellow of the joint CU/NREL adventure: Renewable and Sustainable Energy Institute (RASEI)From:SPIETVViews:0 0ratingsTime:25:17More inScience Technology

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of Charge Carriers in Organic Photovoltaic Devices - Video

Science Café: Ken Storey on the biochemistry of winter hibernation – Video


Science Café: Ken Storey on the biochemistry of winter hibernation
We all know that mammals are warm-blooded and that for humans a drop in core body temperature of only a few degrees can be lethal. However, such strict adherence to a high constant body temperature is not a feature of all mammals. Hibernators readily abandon this concept and let their bodies chill to near zero degrees Celsius while entering a deep torpor. Join Ken Storey, professor in the Departments of Chemistry and Biology, for a talk about the adaptations that allow some mammals to endure life in the cold and how our understanding of these mechanisms could lead to advances in medicine, organ preservation and long-term space flight. Where: Wild Oat Café at 817 Bank Street. When: Wednesday, Nov. 7 from 6:30 pm to 7:30 pm The free 20-minute discussion will be followed by a question and answer session. The Science Café series takes place every second Wednesday until Dec. 5, 2012. The Science Café series is organized by the Faculty of Science at Carleton University to discuss relevant issues facing our society and how science can help solve real-world problems. Meet some of our award-winning faculty members and graduate students as they share their excitement about science with the community. For more information, visit sciencecafe.carleton.caFrom:CarletonUvideosViews:5 0ratingsTime:01:47More inEducation

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Emergent Computation – Video


Emergent Computation
ll4.me Emergent Computation Part 1: Automata Theory and the Biochemistry of Genetics; A Review of Chemistry; A Review of Automata Theory; The Beginning Numbers; Regular Languages: DNA and RNA; Context Free Languages: DNA and RNA; Context Sensitive Languages: DNA, RNA, Proteins; Turing Machines and SubTuring Machines; Splicing Systems, H Systems; tRNA Structure; Semigroups and BioInformatics.- - Part II: Automata Theory and Disciplines Other Than Bioinformatics; Automata Theory: non-Bioinformatics Emergent Computation. Appendix. References. Index EAN/ISBN : 9780387272702 Publisher(s): Springer, Berlin, Springer, New York Discussed keywords: Bioinformatik Format: ePub/PDF Author(s): Simon, Matthew Part 1: Automata Theory and the Biochemistry of Genetics; A Review of Chemistry; A Review of Automata Theory; The Beginning Numbers; Regular Languages: DNA and RNA; Context Free Languages: DNA and RNAFrom:kennethhagerman985Views:0 0ratingsTime:00:13More inPeople Blogs

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Researching potential curing or slowing down of cardiovascular disease

A University of Canterbury student is researching key cell biology processes that may be useful in curing or slowing down the development of many diseases such as strokes and heart attacks.

Nelsons Ben Walters is at the end of his fourth year of UC study working toward a Master of Science in Biochemistry. His area of research is on cardiovascular disease which is a leading cause of mortality in most developed countries, largely due to the ageing population and sedentary lifestyles.

In New Zealand heart attacks and strokes result are responsible for 40 percent of annual deaths, affecting around 10,000 people. Cardiovascular disease involves the build-up of fatty materials such as cholesterol in the cells within the arterial walls in a process known as atherosclerosis.

Fat deposition within the cells begins in teenage years and after enough time, blood circulation can be impaired through artery stiffening and plaque formation. These plaques can eventually rupture and form blood clots that deprive tissues of oxygen and other nutrients.

Depending on the location of clot formation, the resulting tissue damage can be in the form of a heart attack or stroke.

My project is looking at how cells involved in cardiovascular disease regulate production of an antioxidant called 7,8-dihydroneopterin. Antioxidants are protective molecules that protect cells against oxidative stress, a process involved in cardiovascular as well as many other diseases, Walters said today.

An increased understanding of how cells produce such molecules many one day lead to therapeutic drugs to modulate antioxidant production. Such interventional strategies may be useful in curing or slowing down the development of many diseases.

Biochemistry and medical research are extraordinarily fields to be involved in. Everything feels incredibly applicable, as the very processes we learn about are occurring inside ourselves and all other life on the planet.

It is also very rewarding to know that the relatively small contribution that I am making to the vast scientific literature, may one day lead to the development of medicines which could save and improve the quality of millions of lives around the world.

The University of Canterbury has been a great place to study, where world leading facilities/research laboratories and excellent teaching staff means anyone with the inclination can be inspired and excel in their field of interest.

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Researching potential curing or slowing down of cardiovascular disease

Collagen might reduce cancer treatment side effects, CSULB reseacher hopes to prove

LONG BEACH - Collagen is widely known as the substance used in plastic surgery to firm lips and smooth wrinkles.

But researchers are now hoping that the protein, a naturally occurring substance in the body, may hold the key for better cancer treatments that minimize painful side effects.

At Cal State Long Beach, biochemistry professor Katarzyna Slowinska is researching new ways to fight cancer with the use of collagen. This year, she received a four-year, $433,500 grant from the National Institutes of Health to continue her studies on how short strands of amino acids, called peptides, can serve as tiny delivery vehicles for cancer treatments.

Slowinska said collagen, a main building block in human connective tissue, has strong molecules that can be manipulated into carrying and releasing cancer drugs into tumors and even inside tumor cells.

"Collagen has the structure of a triple helix, so it looks like DNA, but instead of having two helices, it has three strands twisted together," she said. "This triple helix makes collagen rigid and strong, which is why it is a main component of connective tissues."

Slowinska said cancer cells are difficult to distinguish from healthy cells, so traditional treatments flood the body with medicine in order to target the abnormal cells. The process, however, is taxing on the body and can cause side effects such as hair loss, exhaustion and organ failure.

Slowinska hopes her research can

"Collagen is naturally derived and it's safer than other treatments so you will not have the bad side effects," she said.

Slowinska, along with 18 of her students, are testing seven lines of cancer cells known to be affected by the drug Paclitaxel, which is used in chemotherapy.

She plans to test other treatments and eventually move on to animal testing. Slowinska hopes her research will add to the larger body of knowledge on how to fight cancer and other diseases.

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Collagen might reduce cancer treatment side effects, CSULB reseacher hopes to prove

E-study Guide For: Introduction To General, Organic And Biochemistry By Frederick A. Bettelheim, Isb – Video


E-study Guide For: Introduction To General, Organic And Biochemistry By Frederick A. Bettelheim, Isb
ll4.me E-study Guide For: Introduction To General, Organic And Biochemistry By Frederick A. Bettelheim, Isbn 9780495391128 - Cram101 Textbook Reviews Never Highlight a Book Again! Just the FACTS101 study guides give the student the textbook outlines, highlights, practice quizzes and optional access to the full practice tests for their textbook.Author: Reviews, Cram101 Textbook Publisher: Cram101 Illustration: N Language: ENG Title: e-Study Guide for: Introduction to General, Organic and Biochemistry by Frederick A. Bettelheim, ISBN 9780495391128 Pages: 00300 (Encrypted EPUB) On Sale: 2012-06-19 SKU-13/ISBN: 9781467256247 Category: Education : General Never Highlight a Book Again! Just the FACTS101 study guides give the student the textbook outlines, highlights, practice quizzes and optional access to the full practice tests for their textbook. Au education, cram101 textbook reviews, generalFrom:rebeccasmith98774Views:0 0ratingsTime:00:16More inPeople Blogs

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Getting Ready for a BioPharma Partnering Deal with Linda Pullan from Pullan Consulting – Video


Getting Ready for a BioPharma Partnering Deal with Linda Pullan from Pullan Consulting
View this ShareVault webinar with Linda Pullan from Pullan Consulting on Getting Ready for a Bio-Pharma Oarnt Agenda: » Should you partner now? » Valuation basics » Process to a deal » Negotiations prep » Negotiations » Term sheets » On to the full agreement Speaker Biography: Linda M. Pullan, Ph.D. offers biotech and pharmaceutical companies consulting in all aspects of partnering through Pullan Consulting (www.pullanconsulting.com). Linda has a Ph.D. in Biochemistry and a BS in Chemistry. Linda has more than 20 years of drug industry experience, beginning in drug discovery at Monsanto/Searle/now Pfizer and ICI/Zeneca/now AstraZeneca. After doing licensing at what is now AstraZeneca, Dr. Pullan continued as head of oncology and hematology licensing for Amgen. She then joined Kosan Biosciences as VP of Business Development and experienced all the tasks of out-licensing and business development in a small company. For several years, she has been providing companies help in identification, evaluation, valuation, negotiation and strategy for partnering in or out. She has an extensive deal sheet ranging from company acquisitions to Phase III compounds and from preclinical candidates to technologies, with both in- and out-licensing. She writes a free monthly newsletter Pullan #39;s Pieces, with tidbits of science and business for about 3600 readers. Interested readers may sign up by sending an email to lpullan@msn.com. Learning Objectives: » Basics of Valuation » Dealmaking ...From:ShareVaultViews:0 0ratingsTime:55:29More inEducation

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