New Therapy May Help Burn Victims

Lesley Kelly, 45, underwent stem cell therapy to repair scar tissue buildup in her right arm. (Cytori Therapeutics, Inc.)

By Lara Salahi, ABC News For more than 40 years, Lesley Kelly of Glasgow, Scotland, lived with third-degree burns that stretched over 60 percent of her body.

Kelly was 2 years old when she fell into a bathtub filled with hot water that scorched most of the right side of her body. She lost full range of motion around many of her joints.

"When you have bad scarring, the buildup is very thick and has no elasticity," said Kelly, 45, whose right elbow was most affected by the buildup of scar tissue. "The problem with thermal burn scarring [is that] it's hard to get the range of motion."

Kelly underwent numerous reparative surgeries through the years, but the scar tissue continued to grow back. The procedures did not lessen the look of her scars.

In 2011, Kelly underwent a new, experimental procedure that used stem cells from her own fat tissue to repair the buildup around her right elbow.

Surgeons cleaned the scar buildup around the elbow and used liposuction to pull fat from off Kelly's waist. They separated the fat cells from the stem and regenerative cells, which were then injected into the wound on Kelly's arm. The procedure took less than two hours.

Within months, Kelly was able to regain 40 degrees of motion that she had lost more than 40 years ago.

"If this technology was available earlier in my life, my scars would not have been as bad," said Kelly.

There are an estimated 50,000 to 70,000 burn cases each year in the U.S., according to the American Burn Association.

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New Therapy May Help Burn Victims

FDA Approves Stemedica Phase II Clinical Trial for Acute Myocardial Infarction With Ischemia Tolerant Mesenchymal Stem …

SAN DIEGO, Calif., Oct. 2, 2012 (GLOBE NEWSWIRE) -- via PRWEB - Stemedica Cell Technologies, Inc., a leader in adult allogeneic stem cell manufacturing, research and development, announced today that the U.S. Food and Drug Administration (FDA) approved its application for an Investigational New Drug (IND) to assess the clinical effects of Stemedyne-MSC (Stemedica's human bone marrow-derived ischemia tolerant mesenchymal cells) in subjects with a myocardial infarct. The Phase IIa double-blinded randomized clinical trial will study approximately forty (40) patients. All patients will initially receive standard care including percutaneous transluminal coronary angioplasty (PTCA) and stenting and, upon completion, will be randomized to receive Stemedyne-MSC intravenously or placebo.

The clinical trial will address the prevalence of cardiovascular disease estimated to carry a global disease burden in excess of $400 billion each year. More than one million patients undergo PTCA and stenting in the Untied States annually; another 800,000 have the procedures each year in Europe.

Nabil Dib, M.D., MSc., F.A.C.C., Director of Cardiovascular Research at Mercy Gilbert and Chandler Regional Medical Centers, and an Associate Professor of Medicine and Director of Clinical Cardiovascular Cell Therapy at the University of California, San Diego, will serve as the principal investigator of the FDA-approved study. Dr. Nib commented, "We've learned from bench top research that not all stem cells are created equally. We believe that the ischemic tolerance of Stemedica's MSCs and the robustness of their protein array will translate into significant patient benefits post myocardial infarction."

Stemedica's interest in this indication was triggered by a successful randomized study in acute myocardial infarction conducted by the National Scientific Medical Center (NSMC) in Astana, Kazakhstan using Stemedyne-MSCs. The study was conducted under clinical protocol and in compliance with the ICH-E6 (Good Clinical Practice) guidelines and local laws. All patients signed an informed consent. Nineteen (19) patients in this study received Stemedyne-MSCs after PTCA and stenting. Administration of Stemedyne-MSC resulted in a statistically-significant decrease in inflammation as judged by the level of C-reactive protein, significant decrease in end-systolic and end-diastolic volume of left ventricle, as well as significant increase in the left ventricular ejection fraction (LVEF) from 38.4% to 54.7% at 6 months post administration, bringing this parameter to a normal range for healthy individuals (50-65%).

Professor Daniyar Jumaniyazov, M.D. Ph.D., principal investigator of the NSMC study commented, "The stem cell transplantation was safe and the procedure was well tolerated. No product-related adverse events were reported. Treatment of patients in this study resulted in improvement of overall and local contractive myocardium functions and also normalization of systolic and diastolic filling of the left ventricle as compared to the control group. Based upon the safety and efficacy results, we will soon conduct a Phase III myocardial infarct clinical trial at the NSMC with Stemedica's ischemia tolerant mesenchymal stem cells."

Lev Verkh, Ph.D., Stemedica Chief Regulatory and Clinical Development Officer commented, "Stemedica's FDA submission included data from the NSMC clinical trial, the results of which were also reported at the annual American College of Cardiology meeting in April, 2012. These results contrasted with reports, at the same conference, of minimal improvement in studies with autologous stem cells. In addition to the United States sites, the study will be duplicated at leading hospitals in Europe, Asia and the Middle East." With regard to the spectrum of stem cell treatment for cardiovascular disease, Dr. Verkh noted that, "Stemedyne-MSC has been approved for the treatment of chronic heart failure at Hospital Angeles, Tijuana, Mexico by COFEPRIS (the Mexican equivalent of the FDA)."

Jackie See, M.D., F.A.C.C., founder of interventional cardiology at the University of California, Irvine, noted, "In the days and weeks following a myocardial infarction we may have the ability to intervene with stem cells to minimize scarring, enhance the amount of functional heart tissue, and restore the microcirculation. Stemedica's ischemia tolerant mesenchymal stem cells are ideal for this purpose. I can foresee the day when all coronary stenting is accompanied by stem cell injection. It is not unreasonable to postulate that the anti-inflammatory and anti-fibrotic effects of the mesenchymal stem cells may have an impact on the incidence of restenosis, a common condition caused by blockage of the stents."

The Stemedyne-MSC product is uniquely manufactured to contain increased amounts of the important growth factors that combat ischemic damage. According to Nikolai Tankovich, M.D., Ph.D., President and Chief Medical Officer of Stemedica, "Our ischemia tolerant MSCs secrete increased amounts of vascular endothelial growth factor (VEGF), which is necessary for new blood vessel development and stromal cell-derived factor (SDF), which is responsible for rescuing dying cells. Stemedyne-MSCs also demonstrate significantly higher migratory abilities. As a company we are unique in our unparalleled scalability, with our master bank at two passages and the cells that go into patients having only been expanded four times. We have the ability to treat more than 500,000 patients with cells created from a single organ donation."

Stemedyne-MSC is one of the three adult allogeneic stem cell products developed by the Company. Other products include Stemedyne-NSC neural human stem cells and Stemedyne-RPE, retinal progenitor epithelial cells available in early 2013. All Stemedica products are unique in their ability to tolerate ischemic conditions.

About Stemedica Cell Technologies, Inc. http://www.stemedica.com

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FDA Approves Stemedica Phase II Clinical Trial for Acute Myocardial Infarction With Ischemia Tolerant Mesenchymal Stem ...

Immune system harnessed to improve stem cell transplant outcomes

ScienceDaily (Oct. 1, 2012) A novel therapy in the early stages of development at Virginia Commonwealth University Massey Cancer Center shows promise in providing lasting protection against the progression of multiple myeloma following a stem cell transplant by making the cancer cells easier targets for the immune system.

Outlined in the British Journal of Hematology, the Phase II clinical trial was led by Amir Toor, M.D., hematologist-oncologist in the Bone Marrow Transplant Program and research member of the Developmental Therapeutics program at VCU Massey Cancer Center. The multi-phased therapy first treats patients with a combination of the drugs azacitidine and lenalidomide. Azacitidine forces the cancer cells to express proteins called cancer testis antigens (CTA) that immune system cells called T-cell lymphocytes recognize as foreign. The lenalidomide then boosts the production of T-cell lymphocytes. Using a process called autologous lymphocyte infusion (ALI), the T-cell lymphocytes are then extracted from the patient and given back to them after they undergo a stem cell transplant to restore the stem cells' normal function. Now able to recognize the cancer cells as foreign, the T-cell lymphocytes can potentially protect against a recurrence of multiple myeloma following the stem cell transplant.

"Every cell in the body expresses proteins on their surface that immune system cells scan like a barcode in order to determine whether the cells are normal or if they are foreign. Because multiple myeloma cells are spawned from bone marrow, immune system cells cannot distinguish them from normal healthy cells," says Toor. "Azacitidine essentially changes the barcode on the multiple myeloma cells, causing the immune system cells to attack them," says Toor.

The goal of the trial was to determine whether it was safe, and even possible, to administer the two drugs in combination with an ALI. In total, 14 patients successfully completed the investigational drug therapy. Thirteen of the participants successfully completed the investigational therapy and underwent a stem cell transplant. Four patients had a complete response, meaning no trace of multiple myeloma was detected, and five patients had a very good partial response in which the level of abnormal proteins in their blood decreased by 90 percent.

In order to determine whether the azacitidine caused an increased expression of CTA in the multiple myeloma cells, Toor collaborated with Masoud Manjili, D.V.M., Ph.D., assistant professor of microbiology and immunology at VCU Massey, to conduct laboratory analyses on bone marrow biopsies taken from trial participants before and after treatments. Each patient tested showed an over-expression of multiple CTA, indicating the treatment was successful at forcing the cancer cells to produce these "targets" for the immune system.

"We designed this therapy in a way that could be replicated, fairly inexpensively, at any facility equipped to perform a stem cell transplant," says Toor. "We plan to continue to explore the possibilities of immunotherapies in multiple myeloma patients in search for more effective therapies for this very hard-to-treat disease."

In addition to Manjili, Toor collaborated with John McCarty, M.D., director of the Bone Marrow Transplant Program at VCU Massey, and Harold Chung, M.D., William Clark, M.D., Catherine Roberts, Ph.D., and Allison Hazlett, also all from Massey's Bone Marrow Transplant Program; Kyle Payne, Maciej Kmieciak, Ph.D., from Massey and the Department of Microbiology and Immunology at VCU School of Medicine; Roy Sabo, Ph.D., from VCU Department of Biostatistics and the Developmental Therapeutics program at Massey; and David Williams, M.D., Ph.D., from the Department of Pathology at VCU School of Medicine, co-director of the Tissue and Data Acquisition and Analysis Core and research member of the Developmental Therapeutics program at Massey.

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World Renowned Scientists and Advocates to Celebrate and Shine Light on Stem Cell Breakthroughs

IRVINE, CA--(Marketwire - Oct 1, 2012) - Oct. 3 marks International Stem Cell Awareness Day, a global celebration where leading scientists, researchers and supporters will acknowledge the scientific advances of stem cell research and its ability to potentially treat a variety of diseases and injuries in the 21st century. This dedicated community is committed to unlocking the potential of stem cells and has made significant strides since the discovery of a method to grow human stem cells less than 15 years ago.

"This is a critical and historic time for stem cell research," said Peter Donovan, Ph.D., director, Sue & Bill Gross Stem Cell Research Center, UC Irvine. "We're literally on the brink of developing new treatments for some of the world's most devastating diseases and injuries. The act of simply raising awareness about this research is one of the best things people can do to help accelerate the process. This event is a great opportunity for everyone to help spread the word and build momentum through a timely mass effort."

Scientists at UC Irvine and other research facilities around the globe continue to work diligently to develop therapies to treat life threatening and debilitating conditions such as Alzheimer's disease, multiple sclerosis, macular degeneration, cancer, Huntington's disease, Parkinson's disease, brain disorders and paralysis caused by spinal cord injuries. These efforts continue to give hope to millions who suffer from these devastating conditions by offering revolutionary treatments and potential cures.

There are several research programs taking place at the Sue & Bill Gross Stem Cell Research Center at UC Irvine that continue to break down barriers and open doors to new treatments for major diseases and injuries:

Spinal Cord and Traumatic Brain Injuries: Neurobiologist Hans Keirstead, Ph.D., as well as husband and wife scientists Aileen Anderson, Ph.D., and Brian Cummings, Ph.D., are conducting stem cell studies to develop treatments for the more than 1.3 million Americans who suffer from spinal cord injuries. Their advancements have led to the world's first clinical trial of human neural stem cell-based therapy for chronic spinal cord injuries (Anderson/Cummings) and the first FDA approved clinical trials using embryonic stem cells (Keirstead). Their research is significant because no drug or other forms of treatment have been able to restore function for those suffering from paralysis. In addition, Cummings and Anderson are applying their stem research to traumatic brain injury, a leading cause of death and disability worldwide, especially in children and young adults.

Alzheimer's Disease: An estimated 35 million people worldwide suffer from Alzheimer's disease, five million of whom live in the U.S. Frank LaFerla, Ph.D., director of UC Irvine's Institute for Memory Impairments and Neurological Disorders, and Matthew Blurton-Jones, Ph.D., of the Sue & Bill Gross Stem Cell Research Center, UC Irvine, have shown for the first time that neural stem cells can rescue memory in mice with advanced Alzheimer's disease, raising hope for a potential treatment in humans. Their work is expected to move to clinical trials in less than five years.

Huntington's Disease: Huntington's disease is a degenerative and ultimately fatal brain disorder that takes away a person's ability to walk, talk and reason. It affects about 30,000 people in the U.S. with another 200,000 or more likely to inherit the disorder. Leslie Thompson, Ph.D., and her team of researchers are currently investigating new stem cell lines and techniques to support the area of the brain that is susceptible to the disease with the hope of developing a cure for future generations.

Macular Degeneration, Retinitis Pigmentosa and Inherited Blindness: Henry Klassen, M.D., Ph.D. has focused his stem cell research on regenerating damaged retinal tissue to restore sight to people suffering from retinitis pigmentosa (an inherited form of degenerative eye disease) and macular degeneration which usually affects older people and leads to loss of vision. Macular degeneration affects millions of Americans. His work hopes to find cures and treatments for corneal and retinal eye disease.

New Website Helps Spread the Word Online To commemorate International Stem Cell Awareness Day and encourage support of stem cell research, an interactive website has been created. Advocates are asked to visit http://www.StemCellsOfferHope.com and share online a wide range of key facts, downloadable images and links to other valuable resources within their social networks.

International Stem Cell Awareness Day Events at UC Irvine The Sue & Bill Gross Stem Cell Research Center at UC Irvine will celebrate International Stem Cell Awareness Day by hosting three special events. An open house will take place on Oct. 1 for high school students. A UC Irvine student, faculty and staff open house will take place on Oct. 2. Finally, an all-day science symposium on Oct. 3 will feature a "Meet the Scientist" interactive forum. The forum and symposium are open to all UC Irvine scientists, clinicians, graduate students, post-docs and members of the community. To RSVP for any these events or for more information, include the name of the event in the subject line and email stemcell@research.uci.edu.

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World Renowned Scientists and Advocates to Celebrate and Shine Light on Stem Cell Breakthroughs

Houston Stem Cell Summit Announces Extraordinary Lineup of Keynote Speakers

HOUSTON, Oct. 1, 2012 /PRNewswire/ --The Houston Stem Cell Summit will host an extraordinary lineup of keynote speakers who represent the most accomplished stem cell scientists, clinicians and entrepreneurs in the United States. Joining these distinguished speakers will be Governor of Texas, Rick Perry, consistent champion of adult stem cell therapies.

(Logo: http://photos.prnewswire.com/prnh/20120831/NY66463LOGO )

The Houston Stem Cell Summit will be held October 26 27 in its namesake city and will highlight the latest therapeutic research regarding the use of adult stem and progenitor cell therapies. The Summit will also provide a forum for entrepreneurs to discuss their latest efforts to commercialize stem cell therapies, and to debate and discuss FDA and other legal and regulatory issues impacting stem cell research and commercialization.

Opening Keynote Address October 26, 2012 Arnold I. Caplan, PhD, Professor of Biology and Professor of General Medical Sciences (Oncology) Case Western Reserve University

Dr. Caplan has helped shape the direction and focus of adult stem cell research and commercialization. Virtually every adult stem cell company and literally tens of thousands of research papers are based on Dr. Caplan's original and ground breaking research. Professor Caplan is considered to be the "father" of the mesenchymal stem cell and first described this progenitor cell in his landmark paper; "Mesenchymal stem cells", Journal of Orthopaedic Research 1991;9(5):641-650. Since that foundational study, Dr. Caplan has published over 360 manuscripts and articles in peer reviewed journals. Dr. Caplan has been Chief Scientific Officer at OrthoCyte Corporation since 2010. In addition, Dr. Caplan co-founded Cell Targeting Inc. and has served as President of Skeletech, Inc. as its founder. He is the recipient of several honors and awards from the orthopedic research community. Dr. Caplan holds a Ph. D. from Johns Hopkins University Medical School and a B.S. in chemistry from the Illinois Institute of Technology.

Summit Keynote Address October 26, 2012 Texas Governor Rick Perry

Governor Perry is the 47th and current Governor of Texas. Governor Perry has long championed the role of medical technologies in building the future of not only Texas, but also the United States. In many ways, his strong advocacy on behalf of research and advanced medical technologies is one of his strongest and as yet underappreciated legacies. In addition to his service to the state of Texas, Governor Perry has also served as Chairman of the Republican Governors Association in 2008 and again in 2011. Despite a rigorous schedule, particularly in the teeth of this election season, Governor Perry has graciously made time to speak and encourage the researchers, patients, companies and physicians who form the fabric and future of the stem cell therapy community.

Texas Medical Center Keynote Address, October 27, 2012 James T. Willerson, MD

Over the course of his career, Dr. James T. Willerson has served as a medical, scientific and administrative leader for each of the major institutions that are the foundation of the Texas Medical Center. Dr. Willerson is currently President and Medical Director, Director of Cardiology Research, and Co-Director of the Cullen Cardiovascular Research Laboratories at Texas Heart Institute (THI). Dr. Willerson was appointed President-Elect of THI in 2004 and became President and Medical Director in 2008. He is also an adjunct professor of Medicine at Baylor College of Medicine and at The University of Texas MD Anderson Cancer Center. He is the former chief of Cardiology at St. Luke's Episcopal Hospital and the former chief of Medical Services at Memorial Hermann Hospital.

Dr. Willerson has served as a visiting professor and invited lecturer at more than 170 institutions.

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Houston Stem Cell Summit Announces Extraordinary Lineup of Keynote Speakers

Contest highlights beauty and spirituality of Two Holy Mosques

The Ministry of Culture and Information yesterday announced winners of a photography competition it organized focusing on the development of the Two Holy Mosques.

A total of 55 photographers including women participated in the contest presenting 139 photos. Among these photos 60 were accepted by the jury, an official statement said.

The winners were: Abdullah Al-Raudan, who won the top prize and a cash award of SR 10,000 for his photograph on the Clock Tower.

Hassan Al-Mubarak was another top prize winner (SR 10,000) for his photograph on Islamic architecture.

Jameela Al-Qadi and Abdullah Al-Shathry won the second prize and a cash award of SR 8,000 each for their photos will receive SR 8,000 cash prize for her photographs on decorated arches. and spirituality.

Third prizewinners, Dania Al-Jahoury and Zahra Al-Qatari, will receive SR 7,000 each for their photos titled light for the worlds and piety respectively.

The ministry has awarded 10 consolation prizes worth SR 5,000 each to Baraka Daifallah, Yousuf Al-Ghamdi, Abdullah Al-Saeed, Ali Al-Nasser, Owaid Hamad Owaid, Mahir Al-Radadi, Munira Al-Suwaiheb, Hala Al-Yousuf, Walid Al-Osaimi and Fahd Al-Oqaili.

The photographers focused on the architectural and spiritual aspects of the Two Holy Mosques and their surroundings.

Muhammad Aabis, director of media at the agency for cultural affairs at the ministry, said the contest was organized to highlight the remarkable development witnessed by the two holy mosques during the Saudi era, especially during the time of Custodian of the Two Holy Mosques King Abdullah.

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Contest highlights beauty and spirituality of Two Holy Mosques

Do you believe in God or another universal spirit? Tips to instill spirituality at home

We are a nation of believers. Mostly. A Gallup poll last year found that 91% of Americans believed in God or some universal spirit. Yet a more recent poll by WIN-Gallup International and published by Religion News Service found that the number of Americans who say they are "religious" dropped from 73% in 2005 to 60% today. And in that poll, 5% of Americans said they are atheists, up from 1% in 2005.

Believing in God doesn't necessarily translate to belonging to an organized religion. And parents who do not belong to a religious institution, as well as those who don't believe in a higher power, are faced with a difficult question: How do they instill spirituality and faith in the children?

Kara E. Powell, assistant professor of youth and family ministry at Fuller Theological Seminary in Pasadena, Calif., says parents need to make themselves available to talk about spirituality and religion at home. They should be extra diligent in making faith a topic that can be discussed so that children won't be confused or ashamed about any observations or questions they might have. Even if there is no organized religion in the home, she says, religious holidays such as Easter and Hanukkah and their rituals can be one of the entry points into the discussion.

"(Another) thing we've seen that's powerful is using current events," says Powell, whose book "Sticky Faith: Everyday Ideas to Build Lasting Faith in Your Kids" (Zondervan, $14.99), offers parents ways to develop long-term faith in teenagers. "Why would God allow X amount of people to be killed in a hurricane or earthquake? Use it as a springboard to talk to kids."

Indeed, getting the ideas of spirituality, faith and respect for faith across to our kids is an uphill climb with or without organized religion.

Wendy Mogel, a clinical psychologist and author of the best-selling parenting book "The Blessing of a Skinned Knee" (Penguin, $15), says that society is awash in irony and cynicism. Couple that with a world that seems to be melting down around us, and parents without organized religion face a deeper challenge.

"We have gloom and doom, a cynical, mocking culture," she says, "and that will be your family's religion if parents don't actively balance that by showing examples and other counter-cultural ways. That means not being cynical, not being apathetic, and not being extremely prejudiced in your beliefs."

That also means letting kids see your values: how you treat others, what your priorities are, how you spend your time.

"Children, absolutely, from birth are theologians and philosophers," she says. If we're not careful, she says, "we can kind of burn it out of them."

There are endless opportunities to instill spirituality. Start with meals. Mogel points to the Jewish tradition of the leisurely meal of Shabbat, and says the idea works for any family, any religion (or nonreligion).

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Do you believe in God or another universal spirit? Tips to instill spirituality at home

Women's spirituality series to be held at Morristonw Jewish Center

Rabbi Amy Joy Small, spiritual leader of the Reconstructionist Congregation Beth Hatikvah in Summit, will lead a two-part series on "Women's Spirituality through Poetry, Story, Torah Commentary and Contemporary Writing." The series, which is sponsored by the National Council of Jewish Women (NCJW), West Morris Section, will be held at noon on Thursdays, Oct. 25 and Nov. 15, in the conference room at Morristown Jewish CenterBeit Yisrael, 177 Speedwell Ave., Morristown. (Entrance to the synagogue is through the back.)

The workshop series is being coordinated by the National Council of Jewish Women, West Morris Section's Our Jewish World, co-chaired by Ellen Nesson and Melanie Levitan, both of Morristown.

Rabbi Small's workshops will be an eclectic introduction to the incredible creativity of Jewish women in crafting both old and new spiritual experiences. The interactive sessions will give participants opportunities to develop their own creative ritual, which they can take with them.

The workshop leader is a fellow of Rabbis Without Borders, a rabbinic leadership program of the National Jewish Center for Learning and Leadership. She is a participant in the Rabbinic Leadership Initiative of the Shalom Hartman Institute, a selective three-year fellowship program. She serves on the board of the MetroWest NJ Partnership for Jewish Learning and Life, and the MetroWest UJC board.

Rabbi Small has been a passionate advocate for Jewish education. Her publications include a chapter in A Women's Haftarah Commentary (edited by Rabbi Elyse Goldstein), and a story in the collections Three Times Chai: 54 Rabbis Tell Their Favorite Stories (edited by Laney Katz Becker) and Text Messages: A Torah Commentary for Teens (edited by Rabbi Jeffrey Salkin).

The two-part workshop on Women's Spirituality is free for National Council of Jewish Women members, West Morris members; the fee for non-members is $6 apiece. But if a non-member pays to join National Council of Jewish Women, West Morris ($35 a year) in advance or at the workshop, she or he can attend the workshop(s) at no charge.

Attendees should bring a bag lunch (no meat, please). Coffee and dessert will be provided.

The National Council of Jewish Women (NCJW) is a grassroots organization of volunteers and advocates who turn progressive ideals into action. Inspired by Jewish values, NCJW strives for social justice by improving the quality of life for women, children, and families and by safeguarding individual rights and freedoms. RSVP to ellen.nesson@gmail.com.

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Women's spirituality series to be held at Morristonw Jewish Center

Feeling Down? Spirituality Can Boost Your Mood

In 2008, then-presidential candidate Barack Obama got himself into trouble by saying "bitter" voters "cling to guns or religion" in response to hard times. Obama later apologized and recanted the statement, but new research suggests he may not have been entirely wrong.

People do turn to spirituality after a bad day, according to a study published online Aug. 1 in the journal Personality and Social Psychology Bulletin. And good news for spiritual folks, it works.

"We find that having a really spiritual day, committing to a power higher than yourself, carefully considering a purpose larger than yourself, it ends up leading to a lot of well-being," said study researcher Todd Kashdan, a psychologist at George Mason University in Virginia. "We find profound levels of meaning in life, greater positive emotions, less negative emotions, higher self-esteem."

Spirituality and happiness

A number of studies have found links between spirituality and happiness. A sense of spirituality, defined as the search for the sacred to differentiate it from organized religion, has even been linked to young women having more sex, perhaps because they feel a greater sense of interconnectedness and intimacy with others.

But most researchers have looked at the link between spirituality in a broad sense, with surveys that ask people about their spirituality in general. Kashdan and his colleagues wanted a day-to-day view. So they asked 87 college students to fill out daily online diaries about their emotions, their spiritual feelings and their self-esteem. They then looked at how spirituality matched up with daily emotional ups and downs.

The participants were a mix of religions, with 34 percent identifying as Catholic, 18 percent as Protestants, and the rest a mix of atheists, Buddhists, Eastern Orthodox, Mormons, Muslims and other faiths.

The diary analysis first found that daily spirituality is associated with a boost in self-esteem and positive mood. The reason, Kashdan told LiveScience, seems to be that spirituality gives people a sense of meaning in life. People's life meaning statistically explained 100 percent of spirituality's positive effect on mood, and 93 percent of the self-esteem boost. [8 Ways Religion Impacts your Life]

Sad today, spiritual tomorrow

For people who are high in spirituality, a bad day was linked to an increase in spiritual behavior, such as meditation or prayer, the next. A good day was associated with fewer spiritual behaviors.

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Feeling Down? Spirituality Can Boost Your Mood

Your Higher Self: Compassion is key response to human suffering

By DR. RAYMOND ANGELINI For The Saratogian

It seems we are constantly being inundated by the media with images of human suffering. We have to look no further than our morning papers for evidence of this. How do we meaningfully and effectively respond to such suffering and tragedy?

I believe that one of the most natural responses to human suffering is to tune it out or ignore it. However, the first step to spiritual enlightenment and social change requires that we bear a compassionate witness to human suffering. Even if there is nothing we can specifically do to help someone who is suffering, there is tremendous spiritual power in remaining aware during someones time of trial.

Buddha was born a wealthy prince. His father, in an attempt to protect him from the trials and tribulations of life, built a wall around the palace. However, Buddha knew that there was much more to life than what was contained within the walls of his fathers palace. Buddha realized that he had to experience suffering to become truly human. Buddha believed that we must open our hearts to suffering in order to become instruments for its transcendence.

This openness to human suffering is called compassion. Compassion is not merely an emotion, it is a spiritual force. It is Gods spirit in action. As Marianne Williamson says in her book, Everyday Grace, Humanitys next great leap in consciousness will be that love is a power to be applied no less than the power of steam or the power of the atom.

So how do we allow the force of compassion to become active in our lives? Every time we bring a meal to a shut-in, hold the hand of a dying friend or take political action to bring about more just social policies, we are practicing active compassion.

However, individual acts of compassion will not in and of themselves be enough to bring about the transformation that is needed. We must strive as a nation and a world to make love and compassion the center of all of our personal, social, political and economic enterprises.

We are at a crossroads in human history. We must all make a choice whether money and power or love and compassion will form the future foundation of our society. If we fail to make a decision, life will make the decision for us. We can either consciously make the decision through wisdom, or unconsciously make it through pain.

I firmly believe that it is Gods will that we become loving and compassionate. I believe that we will ultimately get there, but how we get there, and how soon, is up to us.

Dr. Raymond Angelini is a licensed psychologist and a business and personal coach. His column is published in The Saratogian on the last Saturday of each month. Mail questions to Raymond F. Angelini, Ph.D, P.O. Box 4816, Saratoga Springs, NY 12866, or email newhorizons@spa.net.

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Your Higher Self: Compassion is key response to human suffering

The Tibetan spiritual leader His Holiness the Dalai Lama leaves the Tsug-la Khang temple for lunch on the first day of …

The Tibetan spiritual leader His Holiness the Dalai Lama leaves the Tsug-la Khang temple for lunch on the first day of the teachings on Atishas Lamp for the Path to Enlightenment (jangchup lamdron). At the request of a group of Taiwanese, the Dalai Lama is scheduled to give four days of teachings from October 1-4, 2012 at the main temple, Dharamshala. (Phayul photo/Norbu Wangyal) [Monday, October 01, 2012, Phayul]

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The Tibetan spiritual leader His Holiness the Dalai Lama leaves the Tsug-la Khang temple for lunch on the first day of ...

Overcoming a Parent’s Worst Nightmare

Overcoming a Parents Worst NightmareBereaved Mother Offers Tips on Her

Most Important Life Lesson

Perhaps the worst thing that can happen to a parent is experiencing the loss of a child. However, as one mother shares, its possible to turn ones devastation into spiritual enlightenment and to weave the tragedy into the fabric of your life and your family.

I dont think any parent ever gets over the loss of a child, says Caroline Flohr, whose memoir Heavens Child, (www.heavenschild.com), recounts the transformative death of her 16-year-old twin daughter, Sarah.

Through the web of pain, I have been amazed by the power of family, love and faith in healing. I have learned that death defines not the end of the journey, but a beginning.

Flohr reviews some of the milestones in her journey to inner peace:

Deeper meaning: Through the death of someone so important, you will be changed. The question is how you will be changed. Will you grow, or become diminished? Flohr grew with the realization that death so often viewed as an end is just the beginning of another phase of existence. One of my favorite quotes is from poet Rabindranath Tagore: Death is not extinguishing the light. It is putting out the lamp because dawn has come.

Celebrate life: When the bereaved are able to look at the life of a person who has passed and see more beauty than pain, they should rejoice. The reality of a persons absence will always have an element of sadness, but the joy of wonderful memories is even more powerful. When loved ones leave this Earth, graces are given to those relationships left behind. These are gifts. When we can acknowledge them, our lives can expand in the present.

Ready for anything: Once youve experienced the worst and pulled through, you know you will be able to weather just about any adversity. Maya Angelou wrote, You may encounter many defeats, but you must not be defeated. In fact, it may be necessary to encounter the defeats, so you can know who you are, what you can rise from, how you can still come out of it. Have faith in that inner strength we all harbor, Flohr says.

Appreciate what you have: Life as we know it will come to an end. This includes everyone we know, love and care about; its a fact that we often forget, and its as startling to remember as it is true. Come good or bad, we do not know what the future will bring, which means we should take every opportunity to fully embrace the present, and our loved ones.

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Overcoming a Parent’s Worst Nightmare

Behind the Scenes of Spiritual Enlightenment

A new book by Marc Leavitt takes the reader behind the scenes of 'Spiritual Enlightenment'.

Roseland, Virginia (PRWEB) September 27, 2012

Marc kept meticulous journals detailing the day to day, month to month, and year to year unfolding of the self in detail. His book, Enlightenment: Behind the Scenes is a very personal account of an incredibly impersonal process broken down step by step and presented to the reader almost in slow motion. Marcs story of Enlightenment centers on four life altering Visions that spontaneously occurred while he was living out his day to day life. Until that time, Marc had never experienced anything remotely out of the ordinary. It was after his repeated visit to the world renowned Monroe Institute that things began to take a dramatic turn.

After returning home from a weeklong meditation retreat at the Monroe Institute, Marc writes that I would find myself spontaneously thrust into a vastly more expansive perspective which placed the entire world in a wholly new context. These Visions were progressive in nature as they clearly and pointedly demonstrated the Grand Design of Reality. Describing his book, Marc continues, I outline a play by play account of how four of these Visions shaped a new understanding regarding the true architecture of Reality and how this understanding resolves one of our greatest philosophical paradoxes, the relationship between mind and matter / God and the world.

The current trend is to call this subject Advaita, Nonduality or not-two, which infers that there is only God or more specifically, only Awareness. The implication being that the entire universe along with its inhabitants is actually none other than God or Awareness manifesting as this world of appearances. Marc points out that prior to the word Nonduality, the popular buzz word associated with the subject of Spiritual Enlightenment was Oneness. Of course, the view that the entire world is a manifestation of God or Awareness has a long history in all major religions generally referred to as the Perennial Teachings.

Marc describes that There is an evolutionary flow that dictates our understanding of these Perennial teachings is becoming ever more nuanced by taking us from One-Ness to Non-Dual to a Tri-Unistic perspective. The concept of the Triunity is also found in all major religions as a means to describe the multifaceted aspect of God. Marc maintains that the mystery of our relationship to God is revealed in this Triunistic model of Reality. He concludes, What the Triunistic perspective brings to the conversation is specifically just how and why we are all One and specifically how and why the relationship between man and the world or even man and God are nondual in nature. Whereas the current teachings in Nonduality simply assert that everything is God or Awareness, Marc clearly explains for the first time in lay terms how a Triunistic perspective of Reality explains the natural mechanism that ensures that God or Awareness manifests as the world we all know as home.

Marc Leavitts ebook Enlightenment: Behind the Scenes is available on Kindle, Nook or http://www.enlightenmentbehindthescenes.com

Marc Leavitt Reality Publishers 434-277-9518 Email Information

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Behind the Scenes of Spiritual Enlightenment

Odyssey Moon & NSL Satellites Ltd. to Launch Science Experiments to International Space Station

LOS ANGELES, CA--(Marketwire - Oct 2, 2012) - Douglas, Isle of Man-based Odyssey Moon Ltd. and Israeli-based NSL Satellites Ltd., in partnership with NanoRacks LLC of the U.S., together will fly a number of educational microgravity experiments to the International Space Station (ISS).The next launch of an experiment is scheduled for October 7th on board a SpaceX Falcon 9 rocket from Cape Canaveral.

Rick Sanford, CEO of Odyssey Moon, said, "We at Odyssey Moon are so excited about this opportunity to give students around the globe access to the NASA U.S national lab. For a start-up space technology company it is very impressive that we have lined up over three successful commercial space missions in a three year period."

The three different experiments will look at how cancer cells develop in microgravity, another will determine the direction of the sprouts/roots growth of radish seeds under microgravity, and there is an experiment to examine the hardening of an epoxy resin sample to test the characteristics of the mix in microgravity conditions. These experiments are being developed by Israeli students in Misgav Middle School and OR High School.

Odyssey Moon Chairman Ramin Khadem pointed out that, "Besides the technical expertise that NSL brings to commercial space allowing these terrific experiments to take place, it is such a pleasure to collaborate with them and NanoRacks LLC."

The project is enabled through NanoRacks LLC, which is working in partnership with NASA under a Space Act Agreement as part of the utilization of the International Space Station as a National Laboratory. Says Managing Director Jeffrey Manber, "NanoRacks is delighted to again be working with the educational community, this time for showing students the potential of using space as a tool for learning."

About Odyssey Moon Odyssey Moon Ltd. is developing sustainable commercial systems and services to deliver payloads and instruments to space in support of science, exploration, and commerce.

Odyssey Moon Ltd. plans to meet near-term and long-term global market needs for low cost, reliable and frequent space and lunar access currently unaddressed by large government space programs. By creating alternative commercial delivery systems that provide rapid mission schedules and standardized systems, we provide value-added opportunities for government, academic and commercial customers to conduct space research or technology demonstrations on a simple cost per kilogram basis.

OM Space/Odyssey Moon Ltd. is one of the firstcommercial deep space enterprises and the veryfirst entrant into the Google Lunar Xprize (GLXP) competition.

About NSL Satellites:

NSL Satellites Ltd. is a space technology and education company. Formed in 2009, NSL is involved in many game-changing technologies for space applications and exploration.

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Odyssey Moon & NSL Satellites Ltd. to Launch Science Experiments to International Space Station

Private SpaceX Rocket Test-Fires Engines for Space Station Trip

A private rocket poised to launch its first official cargo delivery run to the International Space Station performed a major engine test this weekend, setting the stage for its planned Oct. 7 liftoff.

The Falcon 9 rocket fired up its nine Merlin engines on Saturday (Sept. 29) for just two seconds during a full dress rehearsal at Florida's Cape Canaveral Air Force Station ahead of the upcoming flight by Space Exploration Technologies (SpaceX).

"During the static fire test today, SpaceX engineers ran through all countdown processes as though it were launch day," SpaceX officials wrote in an update Saturday. "Post static fire, SpaceX will conduct a thorough review of all data, and the Dragon spacecraft will be mated to Falcon 9 in preparation for next Sunday's targeted launch."

The Falcon 9 rocket is scheduled to launch an unmanned Dragon space capsule (also built by SpaceX) on Sunday at 8:35 p.m. EDT (0035 Oct. 8 GMT). If all goes well, the spacecraft should arrive at the International Space Station on Oct. 10, where it will be grappled by a robotic arm controlled by astronauts and attached to a docking port.

The mission follows a similar demonstration flight to the station in May by SpaceX's Dragon spacecraft. But Sunday's launch will kick off the company's first official cargo flight for NASA under a $1.6 billion deal that includes 12 such missions. [Photos: SpaceX's 1st Dragon Flight to Space Station]

The Hawthorne, Calif.-based SpaceX is one of two U.S. spaceflight companies with contracts to provide robotic cargo flights to the International Space Station for NASA. The other firm, Orbital Sciences Corp., of Virginia, has a $1.9 billion contract for eight missions using its new Antares rocket and Cygnus spacecraft. The first Antares rocket rolled out to its launch pad on the Virginia coast today (Oct. 1).

With the retirement of NASA's space shuttle fleet in 2011, the space agency is relying on new privately built spacecraft to ferry American astronauts and cargo to and from low-Earth orbit. The unmanned resupply flights are the first stage of that plan, which also includes purchasing seats for U.S. astronauts on private space taxis once they become available.

SpaceX is one of several companies also seeking to launch astronauts into space for NASA. The company plans to use a crewed variant of its Dragon capsule for the job.

The upcoming Falcon 9 launch will be the fourth flight of the booster for SpaceX and the third flight of a Dragon spacecraft. The Dragon capsule made its first test flight in December 2010, which was followed by a successful round trip to the International Space Station earlier this year during SpaceX's demonstration flight in May.

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Private SpaceX Rocket Test-Fires Engines for Space Station Trip

Release of NASA Research Announcement NNH12ZTT001N "Research Opportunities in Space Biology"

This NASA Research Announcement (NRA) solicits hypothesis-driven research proposals for 1) Ground-Based Research Designed to Lead to Space Flight, 2) Rapid Turn-Around Space Flight Experiments 3) ISS Flight Experiments and 4) New Space Biology Investigations. NASA Space Biology experiments have one or more of the following primary goals: 1) to effectively use microgravity and the other characteristics of the space environment to enhance our understanding of basic biological processes; 2) to develop the scientific and technological foundations for a safe, productive human presence in space for extended periods and in preparation for exploration; and 3) to apply this knowledge and technology to improve our nation's competitiveness, education, and the quality of life on Earth. NASA Space Biology experiments will be designed to discover how space flight affects a diverse group of microorganisms, plants, and animals; study the effects of gravity (g) across the g-spectrum, i.e., from micro- to hyper-gravity; and characterize the biological effects of radiation, magnetic fields, and the interaction amongst species in the unusual environments of space and spacecraft.

The full text of the solicitation is available on the NASA Research Opportunities homepage at http://nspires.nasaprs.com under menu listing "Open Solicitations." Potential applicants are urged to access this site well in advance of the proposal due date to familiarize themselves with its structure and to register in the NSPIRES system. Proposals must be submitted electronically.

Step-1 proposals are due on October 31, 2012 at 5 PM Eastern Time, and invited Step-2 proposals are due on December 19, 2012 at 5 PM Eastern Time. Proposals must be submitted electronically by an authorized official of the proposing organization. Proposers can use either NSPIRES (see URL above) or Grants.gov (http://www.grants.gov) for proposal submission. NASA's selection of research projects will be guided by recommendations of the National Research Council's 2011 Decadal Survey Report, "Recapturing a Future for Space Exploration: Life and Physical Sciences Research for a New Era" (http://www.nap.edu/catalog/13048.html).

All categories of U.S. institutions are eligible to submit proposals in response to this NRA. Principal Investigators (PIs) may collaborate with investigators from universities, Federal Government laboratories, the private sector, state and local government laboratories and other countries.

Every organization that intends to submit a proposal in response to this NRA must be registered with NSPIRES, and such registration must identify the authorized organizational representative(s) who will submit the electronic proposal. Instructions on how to register in NSPIRES will be described in the NRA. Each electronic proposal system places requirements on the registration of principal investigators and other participants (e.g. co-investigators). Potential proposers and proposing organizations are urged to access the system(s) well in advance of the proposal due date(s) of interest to familiarize themselves with its structure and enter the requested information. Questions in regards to responding to this NRA may be addressed to the contacts referenced in the full solicitation document.

This is a broad agency announcement as specified in FAR 6.102 (d)(2). Notwithstanding the posting of this opportunity at FedBizOpps.gov, nspires.nasaprs.com, or Grants.gov, NASA reserves the right to determine the appropriate award instrument for each proposal selected pursuant to this announcement.

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Release of NASA Research Announcement NNH12ZTT001N "Research Opportunities in Space Biology"

Space Shuttle Endeavour Made Final Flight Packed with Souvenir Patches

The space shuttle Endeavour's hatch will be opened by NASA technicians one last time this week, in part to retrieve thousands of souvenir patches and a photo the retired orbiter's final flown cargo.

Endeavour, which is now temporarily parked in a United Airlines hangar at Los Angeles International Airport (LAX), is being prepared for its delivery to the California Science Center (CSC) for display. The shuttle, piggybacking atop a NASA jumbo jet, landed at LAX on Friday (Sept. 21) after a three-day cross-country ferry flight and four-hour flyover of the Golden State.

Just a few days before Endeavour left NASA's Kennedy Space Center in Florida for the final time, the space agency fulfilled a request by the CSC and stowed a care package on the shuttle's mid-deck inside its crew compartment. Stored in a locker, the pouch was flown with the orbiter on its recent ferry flight, which marked the last time a space shuttle ever took to the air.

Over the course of its 25 missions to space, Endeavour flew numerous significant payloads, including equipment to service and upgrade the Hubble Telescope, Spacelab and Spacehab modules, and the components to assemble the International Space Station. [Photos: Shuttle Endeavour's California Sightseeing Tour]

Endeavour's final cargo, carried on what the CSC dubbed "Mission 26: The Big Endeavour," may be more memento than mission-critical, but it still served a purpose: to say thank you.

25:123:12

The California Science Center flew 5,000 woven patches aboard Endeavour featuring a design that celebrated both of the modes of transport responsible for delivering the shuttle to its new display pavilion.

The 4.5-inch wide (11.4 centimeters) colorful badges depict Endeavour soaring on top of NASA's modified Boeing 747 Shuttle Carrier Aircraft (SCA) and riding the self-propelled overland transporter that will take it on its road trip to the CSC. Endeavour is set to depart LAX and travel through Inglewood and Los Angeles city streets on Oct. 12-13 as the final leg of "Mission 26."

The numbers "25:123:12" are inscribed along the top of the patches. The "25" is for Endeavour's 25 missions to space and the "123" represents the 123 million miles (198 million kilometers) the orbiter traveled in flight. The "12" refers to the number of miles the shuttle will travel on the road to the science center.

While black-bordered versions of the patches are already for sale in the CSC's gift shop, the flown patches which are set apart by their gold thread border will not be sold. Instead, say science center officials, they will be given to those who made "Mission 26" possible: team members who worked on the ferry flight and the upcoming overland transport, as well as the center's donors who helped fund Endeavour's temporary and permanent exhibits.

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Space Shuttle Endeavour Made Final Flight Packed with Souvenir Patches

FleX Silicon-on-Polymer Flies in NASA Rocket

BOISE, Idaho--(BUSINESS WIRE)--

American Semiconductor, Inc. today announced the first space flight FleX Silicon-on-Polymer by Team RockSat, a crew of engineering students from Northwest Nazarene University (NNU) in Nampa, Idaho. The NNU RockSat team designed a project to test the effects of radiation on flexible integrated circuits using American Semiconductors FleX process.

The June 21 launch of NASAs 35-foot-tall Terrier-Improved Orion suborbital sounding rocket heralded the first space demonstration of flexible ICs. NNUs RockSat-C experiment included a FleX IC with direct write interconnects in parallel with a traditionally packaged IC for control. Both ICs were fully functional after the 20G launch that propelled the rocket 73 miles into space and subsequent recovery of the rocket from the Atlantic Ocean.

American Semiconductor supported Team RockSats six engineering students in designing and implementing their experiment. The students worked at the NNU campus in Nampa, ID, American Semiconductors R&D facility in Boise, ID, and NASA Wallops Flight Facility in Virginia. After the rocket was recovered Team RockSat showed the FleX IC functioned through the flight with no upset due to radiation effects.

American Semiconductor is proud to sponsor NNU and their innovative engineering program, said Doug Hackler, President and CEO of American Semiconductor. We are committed to supporting engineering and manufacturing capability in the United States and especially in Idaho. We are happy to see NNUs engineering program engage students and industry to produce valuable research.

FleX can be applied to almost any SOI wafer from any IDM or foundry to economically create flexible ICs, said Rich Chaney, General Manager of American Semiconductor. FleX is compatible with printed electronics to create flexible hybrid systems that enable new innovation in many applications including conformal and structurally integrated antennas, structural health monitoring for automotive and aerospace, and flexible consumer electronics.

American Semiconductor, Inc. provides FleX technology as a standard process offering for both commercial and ITAR customer requirements.

American Semiconductor, Inc. is the industry leader in single crystal flexible ICs. As an on-shore, ITAR compliant, pure-play U.S. foundry, American Semiconductor provides services for all aspects of wafer fabrication and process development. Services include process development and process transfer engineering; design engineering including design, verification, layout, and test; and FleX Silicon-on-Polymer technology for flexible CMOS.

American Semiconductor Inc., the American Semiconductor logo, FleX, Silicon-on-Polymer, are trademarks of American Semiconductor, Inc.

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FleX Silicon-on-Polymer Flies in NASA Rocket

Conroy plays down 'red underpants' comments

Federal Communications Minister Stephen Conroy has defended a comment he made about Australian telecommunications bosses wearing red underpants on their heads.

Senator Conroy made the remarks in a presentation he gave in New York earlier this week.

A scratchy recording has emerged of Senator Conroy talking about telecommunications and the cost of broadband in Australia during the presentation.

"I'm in charge of spectrum auctions and if I say to you everyone in this room, 'if you want to bid next week in our spectrum auction you better wear red underpants on your head', you'll be wearing them on your head," he said.

"I have unfettered legal power."

Senator Conroy made the comments comparing the Government's position in the telecommunications industry in Australia to that in the United States.

"Not many regulators have quite that much power," he said.

"But we don't just have the power, we believe we have the responsibility to do something."

He said that is why the Government is committed to the National Broadband Network.

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Conroy plays down 'red underpants' comments