Correlative three-dimensional super-resolution and block-face electron microscopy of whole vitreously frozen cells – Science Magazine

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David P. Hoffman

Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.

Gleb Shtengel

Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.

C. Shan Xu

Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.

Kirby R. Campbell

Department of Developmental Neurobiology, St. Jude Childrens Research Hospital, Memphis, TN 38105, USA.

Melanie Freeman

Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.

Lei Wang

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.Program in Cellular and Molecular Medicine, Boston Childrens Hospital, Boston, MA 02115, USA.Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.

Daniel E. Milkie

Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.

H. Amalia Pasolli

Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.

Nirmala Iyer

Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.

John A. Bogovic

Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.

Daniel R. Stabley

Neuroimaging Laboratory, St. Jude Childrens Research Hospital, Memphis, TN 38105, USA.

Abbas Shirinifard

Bioimage Analysis Core, St. Jude Childrens Research Hospital, Memphis, TN 38105, USA.

Song Pang

Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.

David Peale

Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.

Kathy Schaefer

Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.

Wim Pomp

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.Program in Cellular and Molecular Medicine, Boston Childrens Hospital, Boston, MA 02115, USA.Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.

Chi-Lun Chang

Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.

Jennifer Lippincott-Schwartz

Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.

Tom Kirchhausen

Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.Program in Cellular and Molecular Medicine, Boston Childrens Hospital, Boston, MA 02115, USA.Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.

David J. Solecki

Department of Developmental Neurobiology, St. Jude Childrens Research Hospital, Memphis, TN 38105, USA.

Eric Betzig

Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.Department of Physics, University of California, Berkeley, CA 94720, USA.Howard Hughes Medical Institute, Berkeley, CA 94720, USA.Helen Wills Neuroscience Institute, Berkeley, CA 94720, USA.Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

Harald F. Hess

Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.

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Correlative three-dimensional super-resolution and block-face electron microscopy of whole vitreously frozen cells - Science Magazine

Quick Hits: Biochemistry of sex, native martyrs, music & film – Catholic Culture

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By Thomas V. Mirus (bio - articles - email) | Jun 09, 2017

There is so much we dont know about our own bodies, and none of it gets taught in sex ed. For example:

A man gets vasopressin, a bonding hormone, when he has sex with a woman. This is not up to him; whether he thinks it is no-strings sex or not, he is now hormonally bonded to that particular woman.

Women are automatically attracted by smell to men whose immune system is complementary to their own, but the Pill reverses this, making them attracted to men whose immune system is like their own, like their fathers or brothers (thus, not a biologically correct mate).

I learned this and much more amazing and important information in a recorded talk on the biochemistry of sex given at my alma mater by Project Rachel founder Vicki Thorn. Watch, and share with your teenage (or older) children.

Many Catholics know about the so-called North American Martyrs: saints like Isaac Jogues and Jean de Brebuf who preached the Gospel to the Indians in Canada. But we never hear about the Indian converts who were martyred around the same time. One of these, Joseph Chiwatenhwa, shed his blood for Christ even before Jogues and Brebuf were killed. In fact, he seems to be the first Catholic to have been martyred in North America.

Chiwatenhwa was the first lay administrator of the Catholic Church in Canada, and became a catechist among his Huron people, converting many friends and family members, translating hymns and prayers from French into Huron, and adapting some Huron traditions to the Catholic faith. He was a man of great zeal and loved God more than his own life. He was ultimately killed (whether by a Huron or an Iroquois is uncertain) for spreading the faith among the native peoples.

To learn more, read Friends of God: The Early Native Huron Church in Canada, a short and moving book written to further the cause of Joseph Chiwatenhwas canonization. (At one point in Friends of God there is a reference to St. Joseph wanting to divorce Mary because he thought she had been unfaithful to him, which I think is the wrong interpretation, but other than that the book is very good.)

Catholics shouldnt trust the mainstream media when it comes to foreign policy any more than they should on matters of religion. Andrew Bacevich recently raised 24 fundamental questions that must be answered for America to have a morally rational foreign policy. That virtually none of them are brought up by the mainstream media or politicians shows how truly impoverished the discussion on foreign policy is.

Two artistic discussions Ive enjoyed recently: Catholic conductor Manfred Honeck talks to the Catholic Artists Society about Faith in Music, with a particularly interesting look at the theological content of Mozarts Requiem. And philosopher Thomas Hibbs asks, Is Cinema Art? The answer is an obvious yes, but we learn more by pursuing the question. One fun bit of trivia I learned from Hibbs: T.S. Eliots favorite film was Kurosawas Throne of Blood.

Finally, Ive just profiled a New York-based Catholic sculptor, Christopher Alles, for The New Criterions blog. Enjoy!

Thomas V. Mirus is an administrative assistant and writer at CatholicCulture.org. A jazz pianist with a music degree, he often takes the lead in our commentary on the arts. See full bio.

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Quick Hits: Biochemistry of sex, native martyrs, music & film - Catholic Culture

Chemistry Department – Undergraduate College

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Welcome to the Department of Chemistry at Wake Forest University. Chemistry is often referred to as the central science because of its role in connecting the physical sciences with the life sciences and applied sciences such as medicine and engineering. You will find that to be true here at Wake Forest in our teaching and in our research which highlights connections to biology, engineering, medicine, and physics.

By recognizing the dynamic nature of science, the Chemistry Department aims to lead in undergraduate and graduate education and in research opportunities that extend beyond the traditional boundaries of chemistry. In this pursuit, our faculty, staff and students alike are committed to developing and using their creativity and critical thinking skills to achieve excellence in inquiry, discovery, application, and service. The departments collegial spirit of respect and cooperation underlies and facilitates the many truly outstanding contributions to education and chemical research that we boast.

If you have questions about our department you can feel free to contact me and I will answer them if I can or point you toward someone who can if I cannot.

Mark E. WelkerChair, Department of ChemistryWilliam L. Poteat Professor of Chemistry

Akbar Salam is a minimalist when it comes to conducting his Chemistry research, relying on blank sheets of paper over a laboratory equipped with high-tech gear. He tends to work on quantum mechanics at a table either in his house Continue reading

The Chemistry Department has hired two new tenure track assistant professors this week, Dr. Elham Ghadiri and Dr. Troy Stich. Dr. Ghadiri got her BS and MS in Physics at Arak University in Iran, then her PhD in Chemistry at Continue reading

The patent filed a year ago for the development of carbon-based catalyst for the waste-to-bioenergy conversion was issued last week. The work was done in collaboration with ORNL and was initiated by a superb collaboration between two alums: Zach Hood Continue reading

Testing for lead in water atschools The testing in Winston-Salem Forsyth County happened because of a research professor at Wake Forest University. Doctor George Donati won a national grant to buy a machine that tests samples to measure low concentrations Continue reading

Sometimes, you can find community in the most unlikely places, like a 25-seat black and gold shuttle bus. Students ride the shuttle to get from point A the Reynolda Campus to point B Wake Downtown. But if Continue reading

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Chemistry Department - Undergraduate College

Sussex University scientist wins award for DNA research – Brighton and Hove News

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A Sussex University academic has been recognised for his work with one of the most prestigious prizes for scientific research.

Laurence Pearl, head of the universitys Life Sciences School, has won the Novartis Medal and Prize in the Biochemical Society Awards 2018.

Professor Pearl received the prize for his research into the structural biology of DNA repair, protein kinase signalling and molecular chaperones.

The Novartis Medal and Prize is awarded annually in recognition of the contribution scientists make to the development of biochemistry.

Professor Pearl, who has led the Life Sciences School since 2009, is not the first recipient with Sussex links.

His predecessors include two Nobel Prize winners the first recipient, Professor Sir John Kappa Cornforth, and Sir Paul Nurse, who began his research career at Sussex.

They also include Professor Sir Tom Blundell, who lectured in biochemistry at Sussex, and Professor Sir Adrian Bird, who was one of the universitys first ever biochemistry students.

The Novartis Medal and Prize winner is named as part of the Biochemical Societys annual awards which recognise 11 scientists for the excellence of their work and the profound impact their research has had on the scientific community and wider society.

Laurence Pearl

Ive been incredibly lucky with the clever and determined people whove come to work with me over the years and our international network of collaborators.

We are deeply indebted to Cancer Research UK and the Wellcome Trust for their generous long-term support which has given us the space to ask really interesting and difficult questions.

The acting chairman of the awards committee, Professor Colin D Bingle, said: Professor Pearl is an impressive biomedical scientist who has made significant contributions to our understanding.

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Sussex University scientist wins award for DNA research - Brighton and Hove News

UC San Diego Receives $7.5 Million to Develop Innovative Uses for Melanin – Scripps Oceanography News

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A team of scientists from the University of California San Diego and two other universities has received a five year, $7.5 million grant from the U.S. Department of Defense to unravel the fundamental properties of melanins, a family of natural pigments found in skin, hair, eyes and even the plumage of brightly colored birds.

The basic research effort, which will be conducted in part by Scripps Institution of Oceanography marine biologist Dimitri Deheyn, will focus on elucidating the biochemical pathways that lead to the production of melanins in a range of organismscompounds that efficiently absorb ultraviolet light and protect skin cells in humansand gain a better understanding of the chemistry and morphology of melanin polymers at the molecular scale, nanoscale, micrometer and at the macroscale.

The project is being funded by the Air Force Office of Scientific Research, under the Defense Departments Multidisciplinary Research Initiative, or MURI program, with the goal of using these natural pigments to develop new kinds of advanced materials.

Melanin is a ubiquitous natural material that has so far been underutilized in materials science and technological applications, said Nathan Gianneschi, a professor of chemistry and biochemistry, materials science and engineering and nanoengineering at UC San Diego, who heads the research team. But this polymer has a unique blend of properties, including strong ultraviolet and gamma radiation absorbance, a high refractive index, material toughness, high conductivity, magnetism and a high metal-binding capacity.

By unraveling the basic biology, chemistry and structural properties of melanins at multiple length scales, the team plans over the next three years to provide the foundation for the development of melanin-based synthetic materials for a wide range of applications.

We hope this basic research effort will eventually lead to the establishment of new methods of assembly to create functional arrays and structures that can be integrated into materials, providing them with unprecedented new optical, infrared, magnetic and biochemical properties, said Gianneschi.

Other melanin-based materials, the researchers added, could include new kinds of adaptive camouflage or detection systems, protective coatings that make structures resistant to ultraviolet and gamma radiation, and bioremediation devices that employ the ability of melanins to bind heavy metals.

Other members of the research team from UC San Diego are Michael Burkart, professor of chemistry and biochemistry and Jeffrey Rinehart, an assistant professor of chemistry and biochemistry. Ali Dhinojwala from the University of Akron and Arthi Jayaraman from the University of Delaware round out the multidisciplinary team.

The research team will collaborate with Wendy Goodson from the Air Force Research Laboratory and Matthew Shawkey, an associate professor of biology at the University of Ghent in Belgium, who were awarded an additional $1.25 million from the Air Force Office of Scientific Research for a cooperative research project.

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UC San Diego Receives $7.5 Million to Develop Innovative Uses for Melanin - Scripps Oceanography News

Faculty Recognized for Achievements at Awards Recognition … – Southern Miss Now

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University of Southern Mississippi faculty members were honored for achievements in teaching, research, service and leadership at the annual Faculty Awards Recognition Ceremony, held May 5 at the Trent Lott Center on the Hattiesburg campus. The event was sponsored by USMs Office of the Provost and Faculty Senate.

Faculty members and their awards/recognition include the following:

*Higher Education Appreciation Day-Working for Academic Excellence (HEADWAE) - Dr. Jiu Ding, Mathematics.

*Nina Bell Suggs Endowed Professorship (2016-17) Dr. Allison Abra, History; Dr. Matthew Casey, History; Dr. Song Guo, Chemistry and Biochemistry; Dr. Donald Sacco, Psychology.

*USM nominee, IHL Diversity Award for Excellence Dr. Mohamed Elasri, Biological Sciences.

*University Excellence Awards Tisha Zelner, Excellence in Service; Dr. Mac Alford, Excellence in Teaching.

*Grand Marshal Dr. David R. Davies, Mass Communication and Journalism.

*USM nominees, National Endowment for the Humanities Award Dr. Matthew Casey History, Dr. Andrew Ross, History.

*Faculty Senate Junior Faculty Awards Dr. Alexandra Valint, English (Teaching); Allen Chen, Psychology (Creative Activity); Dr. Donald Sacco, Psychology (Faculty Research). *Aubrey Keith and Ella Ginn Lucas Endowment for Faculty Excellence Awards Dr. Dan Capper, Religion; Dr. Matthew Casey, History; Dr. Westley Follett, History; Dr. Joshua Haynes, History; Dr. Mark Huff, Psychology; Dr. Shalid Karim, Biological Sciences; Dr. Lucas Keefer, Psychology; Dr. Webb Parker, Music; Dr. Ann Blankenship, Educational Research and Administration; Dr. Jonathon Pluskota, Mass Communication and Journalism; Dr. Stephanie Smith, Psychology; Dr. Timothy Tesh, Music; Dr. Kimberly Ward, Speech and Hearing Sciences; Dr. Matthew Ward, Anthropology and Sociology; Dr. Fei Xue, Mass Communication and Journalism.

*Summer Grants for Improvement of Instruction Dr. Hugh Broome, Chemistry and Biochemistry; Dr. Max Grivno and Dr. Jill Abney, History; Dr. James Lambers, Mathematics; Cynthia Littlejohn and Melissa Gutierrez, Biological Sciences; Dr. Andrew Ross, History; Dr. Jeremy Scott, Physics and Astronomy; Dr. Katie Smith, Anthropology and Sociology; and Dr. Alan Thompson, Criminal Justice.

*Association for College and University Educators (ACUE) Faculty Development Institute Certificate in Active Learning Dr. Cindy Blackwell, Mass Communication and Journalism; Dr. Ann Blankenship, Educational Research and Administration; Dr. Hugh Broome, Chemistry and Biochemistry; Dr. Nick Ciraldo, Music; Dr. Mike Davis, Biological Sciences; Haley Dozier, doctoral student, Mathematics; Dr. Mary Funk, Interdisciplinary Studies; Dr. Max Grivno, History; Melissa Gutierrez, Biological Sciences; Linda Hanson, Chemistry and Biochemistry; Dr. Katie James, Anthropology and Sociology; Dr. Sungsoo Kim, Economic Development, Tourism and Sport Management; Cynthia Littlejohn, Biological Sciences; Dr. Courtney Luckhardt, History; Candice Mitchell, graduate student, Mathematics; Marlene Naquin, Mathematics; Dr. Rebecca Newton, Nursing; Dr. Jennifer Osborne, Curriculum, Instruction and Special Education; Dr. Jonathon Pluskota, Mass Communication and Journalism; Dr. Jennifer Regan, Biological Sciences; Renee Rupp, Nutrition and Food Systems; Dr, Gregory Smith, Curriculum, Instruction and Special Education; Dr. Katie Smith, Anthropology and Sociology; Corwin Stanford, Mathematics; Dr. Steven Stelk, Finance, Real Estate and Business Law; Dr. Gallayanee Yaoyuneyong, Marketing and Merchandising; Dr. Zhu Huiqing, Mathematics; Melissa Ziegler, Kinesiology.

*Innovation in Online Teaching Award Dr. James T. Fox, Educational Research and Administration.

*University Research Council Innovation Awards Dr. Donald Sacco, Psychology, Basic Research Award; Dr. Philip Bates, Chemistry and Biochemistry, Applied Research Award; Mark Rigsby, Art and Design; Creative Activities Award; Dr. Robson Storey, Polymers and High Performance Materials, Academic Partnership Award; Dr. Vijay Rangachari Chemistry and Biochemistry, Multidisciplinary Award; Dr. Marie Danforth, Anthropology and Sociology, Research Advocate Award; Khem Raj Budachetri, Biological Sciences, Graduate Student Award.

USM Faculty Senate Resolutions announced at the ceremony included those honoring recently deceased faculty members Dr. Stan Kuczaj, Psychology; Dr. Ed Nissan, Economics; and Dolly Loyd, Marketing.

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Faculty Recognized for Achievements at Awards Recognition ... - Southern Miss Now

Immature spinner dolphin calf SCUBA tanks spell disaster in tuna … – Phys.Org

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April 19, 2017

Dolphins that live in the deep ocean have well developed oxygen storage, but now it turns out that spinner dolphin calves do not develop their SCUBA capacity any faster than coastal species, despite their deep diving lifestyle. Shawn Noren from the University of California, Santa Cruz has also calculated that delays in developing their oxygen storage could place spinner dolphin calves at risk of separation from their mothers during high speed tuna purse seine-fishery pursuits.

Just because dolphins are born in water doesn't necessarily mean that their in-built SCUBA system is fully prepared for action at birth; it can take between 1 and 3 years for the oxygen carrying capacity of whales and dolphins to mature sufficiently. Shawn Noren, from the University of California, Santa Cruz, USA, explains that the muscles of fully developed diving species - including dolphins, whales, birds and seals - contain more of the oxygen carrying protein, myoglobin, than land-based animals and are better prepared to neutralise lactic acid produced in the muscles when divers switch to anaerobic respiration after exhausting their oxygen toward the end of a dive.

"We wondered if pelagic (offshore) living promotes rapid postnatal maturation of muscle biochemistry", says Noren. In other words, might deep-diving ocean-going whales and dolphins develop large reserves of myoglobin and the ability to buffer muscle against acid earlier in in life than species that remain in shallow coastal waters? Noren and her colleagues measured the oxygen storage capacity and muscle biochemistry of spinner dolphin swim muscles and discovered that they matured no faster than the muscles of coastal species. They also publish their calculations suggesting that the muscles' slow development could place calves at risk of separation from their mothers during pursuits by commercial fishing fleets in Journal of Experimental Biology.

As it is almost impossible to collect muscle samples from spinner dolphins in the open ocean, Noren depended on Kristi West, from Hawaii Pacific University, USA - who set up a dolphin stranding program in Hawaii 11 years ago and attends all strandings on the island - to collect the essential samples. Over 7 years, West collected small portions of the swimming muscle from 17 spinner dolphins that her team had been unable to rescue - ranging in age from a foetus that died during birth to newborns, adolescents and fully grown males and females. She then shipped the samples to Santa Cruz, where Noren painstakingly analysed the muscles' myoglobin content and how much sodium hydroxide she had to add to 0.5g of minced muscle to raise the pH from 6 to 7 to measure the muscle's buffering capacity against anaerobic acid production. Plotting the animals' body lengths (which correlate well with their ages) against their muscle myoglobin content, Noren could see that the dolphins' abilities to carry oxygen continued increasing as the animals aged. The ability of the muscle to buffer against pH changes also increased gradually; however, it reached the capacity of the mature dolphins and plateaued at an age around 1.6-2 years, when the dolphin youngsters are weaned, which is similar to the age at which the diving apparatus of some coastal species reaches maturity.

So ocean-going spinner dolphin calves do not develop the physical characteristics that are essential to sustain deep dives any faster than shallow-diving coastal species, such as bottlenose dolphins. However, the youngest spinner dolphins already had higher concentrations of muscle myoglobin than coastal bottlenose dolphins at the same ages, and the adult spinner dolphins' myoglobin concentrations (6-7.1g of Myoglobin/100g of wet muscle mass) matched those that had been measured previously for other champion divers, including short-finned pilot whales and Gervais' beaked whales.

But what implications might the relatively slow development of their diving apparatus have for young spinner dolphins in the Eastern Tropical Pacific? Knowing that tuna purse-seine fisheries in this region specifically target dolphin pods - they pursue the animals to exhaustion before encircling them in enormous nets to capture the tuna shoals that reside beneath - Noren calculated that an immature calf that cannot keep up might be adrift of its mother by up to 15.4km by the end of a 100min pursuit. Noren says, "The relatively underdeveloped muscle biochemistry of calves likely contributes to documented mother-calf separations for spinner dolphins chased by the tuna purse-seine fishery", and this could affect dolphin populations dramatically if our hunger for tuna continues to separate dolphin calves from their mothers.

Explore further: International collaboration working to enhance protections for spinner dolphins

More information: Noren, S. R. and West, K. (2017). Muscle biochemistry of a pelagic delphinid (Stenella longirostris longirostris): insight into fishery-induced separation of mothers and calves. J. Exp. Biol. 220, 1490-1496. DOI: 10.1242/jeb.153668

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University of Toronto researchers have identified a gene that determines whether the body will adapt to changing seasons.

A new paper in the prestigious journal Nature from Brandeis researchers in the laboratory of James Haber provides a detailed description of the processes of DNA repair.

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Immature spinner dolphin calf SCUBA tanks spell disaster in tuna ... - Phys.Org

Team characterizes the underlying cause of a form of macular … – Medical Xpress

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April 19, 2017 by Katherine Unger Baillie The Penn-led research team characterized the underlying mechanism that leads to the blinding Best disease; a loss of the microvilli that support and "feed" photoreceptor cells. The contrast can be seen above, with a normal retina on the right and an affected on on the left. Credit: University of Pennsylvania

Named for Friedrich Best, who characterized the disease in 1905, Best disease, also known as vitelliform macular dystrophy, affects children and young adults and can cause severe declines in central vision as patients age. The disease is one in a group of conditions known as bestrophinopathies, all linked to mutations in the BEST1 gene. This gene is expressed in the retinal pigment epithelium, or RPE, a layer of cells that undergirds and nourishes photoreceptor cells, the rods and cones responsible for vision.

Despite the century of work on bestrophinopathies and the identification of genetic mutations responsible for the conditions, no one had identified the underlying mechanism that led to the vision loss seen in Best disease until now.

Using an animal model of Best disease in combination with biochemical and optical assays, a team of researchers at the University of Pennsylvania has pinpointed a number of abnormalities that give rise to the impairments seen in the disease.

"The genetic cause of the disease has been known for 20 years, but no one had samples of patients at the stage when the disease starts," said Karina E. Guziewicz, research assistant professor of ophthalmology in Penn's School of Veterinary Medicine and lead author on the study. But "we were now able to pinpoint this early stage and find out what factors trigger the development of lesions."

The new information sets the team up for testing a gene therapy to treat the disease, as the researchers will be able to observe whether or not these structural and biochemical abnormalities have been corrected.

"Now that we understand what we're seeing, it allows us to judge the success of a particular therapy," said Gustavo D. Aguirre, professor of medical genetics and ophthalmology at Penn Vet.

Kathleen Boesze-Battaglia, a professor in the Department of Biochemistry in Penn's School of Dental Medicine, also contributed her expertise in lipid biochemistry and spectral analysis of lipid debris to the study, which was published in the journal Progress in Retinal and Eye Research, the top ranked journal in the eye-research field.

"Interestingly, the lipid debris accumulation is similar to cholesterol rich plaque formation, compounded by a complexity of vitamin A metabolism," said Boesze-Battaglia. "Alterations in lipid metabolism likely contribute to the secondary disease pathology in this model."

The main puzzle surrounding Best disease was why, despite the BEST1 gene being mutated in the RPE throughout the retina, vision loss struck the macula and fovea, the central areas of the retina responsible for reading and tasks requiring high-resolution vision, while seeming to spare the rest. Researchers had observed lesions in this area, but it was unknown why they developed.

In this study, the Penn-led team discovered that this predilection of the macula to develop lesions has to do with differences in the supporting structures of rods versus cones.

Rods, which make up more than 90 percent of photoreceptor cells in the retina and are responsible for dim-light vision, have a cluster of supporting structures known as RPE microvilli that cup the cell like stakes holding up a plant. In contrast, cones, the color-sensing photoreceptors that make up 3 to 5 percent of all photoreceptors but are overrepresented in the macula, are engulfed in a sheath of microvilli. In addition, cones are supported by an insoluble matrix.

Examining cross-sections of the fovea-like region in the canine macula of dogs affected with the canine equivalent of Best disease, the researchers found that the microvilli don't form and that the matrix is fragmented. The susceptibility of the macula is due to the fact that cones are the predominant cell type there and rely on the matrix for support and nutrient exchange.

"We were not expecting to find such dramatic structural abnormalities," Guziewicz said. "For a hundred years, this has been thought to be a disease of the RPE, but we have now identified this as a disease of the RPE-photoreceptor interface."

"The RPE provides transport of nutrients to the cones and engulfs the discarded part of cones and rods," said Aguirre. "When you lose the matrix, you lose the connection between those cells and the RPE and that leads to disease."

To determine if the same would be true in humans, the researchers looked at human induced pluripotent stem cell-derived RPE from Best disease patients and found similar signatures: microvilli numbers were decreased in length and density. These experiments were conducted in collaboration with David Gamm's laboratory from the McPherson Eye Research Institute at the University of Wisconsin-Madison.

Looking ahead, the research team would like to continue to probe the biochemical signals that lead to the improper development of the microvilli and matrix and push ahead with developing and testing a gene-therapy approach to treating bestrophinopathies.

"Knowing where the disruptions occur will allow us to develop proper outcome measures for a gene therapy, which is in the works," said Guziewicz.

Explore further: Fighting blindness: Scientists bring a key protein into focus

More information: Karina E. Guziewicz et al, Bestrophinopathy: An RPE-photoreceptor interface disease, Progress in Retinal and Eye Research (2017). DOI: 10.1016/j.preteyeres.2017.01.005

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Vitelliform macular dystrophy, also known as Best disease, is one of a group of vision-robbing conditions called bestrophinopathies that affect children and young adults. Caused by inherited mutations in the BEST1 gene, these ...

In humans, a tiny area in the center of the retina called the fovea is critically important to viewing fine details. Densely packed with cone photoreceptor cells, it is used while reading, driving and gazing at objects of ...

Three years ago, a team from the University of Pennsylvania announced that they had cured X-linked retinitis pigmentosa, a blinding retinal disease, in dogs. Now they've shown that they can cure the canine disease over the ...

Named for Friedrich Best, who characterized the disease in 1905, Best disease, also known as vitelliform macular dystrophy, affects children and young adults and can cause severe declines in central vision as patients age. ...

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Team characterizes the underlying cause of a form of macular ... - Medical Xpress

Biochemistry Analyzers Market: Capacity, Production, Revenue, Price and Gross Margin by 2022 – MilTech

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United States Biochemistry Analyzers market is valued at USD XX million in 2016 and is expected to reach USD XX million by the end of 2022, growing at a CAGR of XX% between 2016 and 2022.

Biochemistry Analyzers Market is expected to witness growth of international market with respect to advancements and innovations including development history, competitive analysis and regional development forecast.

The report starts with a basic Biochemistry Analyzers market overview. In this introductory section, the research report incorporates analysis of definitions, classifications, applications and industry chain structure.

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Biochemistry Analyzers Market split by application,report focuses on consumption, market share and growth rate of Biochemistry Analyzers in each application and can be divided into

Browse more detail information about Biochemistry Analyzers Market at:http://www.360marketupdates.com/10582066

To begin with, the report elaborates the Biochemistry Analyzers Market overview. Various definitions and classification of the industry, applications of the industry and chain structure are given. Present day status of the Biochemistry Analyzers Market in key regions is stated and industry policies and news are analysed.

Following are the key players covered in this Biochemistry Analyzers Market research report:

And Many Others

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After the basic information, the Biochemistry Analyzers Market report sheds light on the production. Production plants, their capacities, global production and revenue are studied. Also, the Biochemistry Analyzers Market growth in various regions and R&D status are also covered.

Following are Major Table of Content of Biochemistry Analyzers Industry:

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Scope of the Biochemistry Analyzers Industry on the basis of region:

Additionally, type wise and application wise consumption figures are also given. With the help of supply and consumption data, gap between these two is also explained.

To provide information on competitive landscape, this report includes detailed profiles of Biochemistry Analyzers Market key players. For each player, product details, capacity, price, cost, gross and revenue numbers are given. Their contact information is provided for better understanding.

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Biochemistry Analyzers Market: Capacity, Production, Revenue, Price and Gross Margin by 2022 - MilTech

Biochemistry Analyzer Market Forecast 2022: Global & Chinese Key Manufactures, Challenges, Opportunities – MilTech

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Biochemistry Analyzer Market report provides key statistics on the market status of the Biochemistry Analyzer Manufacturers and is a valuable source of guidance and direction for companies and individuals interested in the Biochemistry Analyzer industry.

The Biochemistry Analyzer Market report delivers a basic overview of the industry including its definition, applications and manufacturing technology. Also, the Biochemistry Analyzer industry report explores the international and Chinese Major Market players in detail.

The Biochemistry Analyzer market report presents the company profile, product specifications, capacity, production value, Contact Information of manufacturer and market shares for each company.

Through the statistical analysis, the Biochemistry Analyzer market report depicts the global and Chinese total market of Biochemistry Analyzer industry including capacity, production, production value, cost/profit, supply/demand and Chinese import/export. The total market is further divided by company, by country, and by application/type for the competitive landscape analysis.

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Table of Contents:

Chapter 1 Overview of Biochemistry Analyzer Market1.1 Brief Overview of Biochemistry Analyzer Industry 1.2 Development of Biochemistry Analyzer Market 1.3 Status of Biochemistry Analyzer Market

Chapter 2 Manufacturing Technology of Biochemistry Analyzer Industry2.1 Development of Biochemistry Analyzer Manufacturing Technology 2.2 Analysis of Biochemistry Analyzer Manufacturing Technology 2.3 Trends of Biochemistry Analyzer Manufacturing Technology

Chapter 3 Analysis of Global Biochemistry Analyzer Market Key Manufacturers3.1.1 Company Profile 3.1.2 Product Information 3.1.3 2012-2017 Production Information 3.1.4 Contact Information

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Chapter 4 2012-2017 Global and Chinese Biochemistry Analyzer Market4.1 2012-2017 Global Capacity, Production and Production Value of Biochemistry Analyzer Market 4.2 2012-2017 Global Cost and Profit of Biochemistry Analyzer Market 4.3 Market Comparison of Global and Chinese Biochemistry Analyzer Industry 4.4 2012-2017 Global and Chinese Supply and Consumption of Biochemistry Analyzer Market 4.5 2012-2017 Chinese Import and Export of Biochemistry Analyzer

Chapter 5 Market Status of Biochemistry Analyzer Industry5.1 Market Competition of Biochemistry Analyzer Industry by Company 5.2 Market Competition of Biochemistry Analyzer Industry by Country (USA, EU, Japan, Chinese etc.) 5.3 Market Analysis of Biochemistry Analyzer Consumption by Application/Type

Chapter 6 2017-2022 Market Forecast of Global and Chinese Biochemistry Analyzer Market6.1 2017-2022 Global and Chinese Capacity, Production, and Production Value of Biochemistry Analyzer market 6.2 2017-2022 Biochemistry Analyzer market Cost and Profit Estimation 6.3 2017-2022 Global and Chinese Biochemistry Analyzer Market Share 6.4 2017-2022 Global and Chinese Supply and Consumption of Biochemistry Analyzer 6.5 2017-2022 Chinese Import and Export of Biochemistry Analyzer

Continue

In the end, the Biochemistry Analyzer market report makes some important proposals for a new project of Biochemistry Analyzer Industry before evaluating its feasibility. Overall, the report provides an in-depth insight of 2012-2022 global and Chinese Biochemistry Analyzer market covering all important parameters.

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Biochemistry Analyzer Market Forecast 2022: Global & Chinese Key Manufactures, Challenges, Opportunities - MilTech

Three College of Science students honored by Barry Goldwater Scholarship Foundation – Clemson Newsstand

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Bridget Luckie (left), Caitlin Seluzicki and Jessica Zielinski were honored by the Barry Goldwater Scholarship and Excellence in Education Foundation. Image Credit: Jim Melvin / Clemson University

CLEMSON, South Carolina To win one of the nations most prestigious undergraduate awards, students must be intelligent, productive and tireless.

But theres one more element that cant be missing in their resumes: a passion for their work.

Clemson Universitys winners of the 2017 Barry M. Goldwater Scholarship Caitlin Seluzicki and Jessica Zielinski, both of the College of Science ranked passion above everything else.

I think we are driven by the passion to want to accomplish something that is going to help people, said Seluzicki, a junior majoring in microbiology. Science is hard work, but the desire to get up every morning and stay up late every night in order to discover something and help others is what motivates us to never give up.

As a scientist, you get out what you put in, added Zielinski, a junior majoring in biochemistry. Its an investment that grows with time and effort, and the more invested you become in the process, the more you treasure your accomplishments and appreciate the broader scope of your research.

The Goldwater Scholarship is the premiere undergraduate award in the fields of mathematics, natural sciences and engineering. This year, Clemson University nominated four students. Of those nominees, Seluzicki and Zielinski were winners; and a third, Bridget Luckie, received honorable mention.

Seluzicki and Zielinski will receive one-year scholarships that will cover the cost of tuition, fees, books and room and board up to a maximum of $7,500. Though Luckie will not receive any funds, she will share equally in the prestige. Goldwater scholars and honorable mentions often go on to win numerous other distinguished awards during their collegiate careers.

My mentors in the academic setting have told me that you dont become a scientist for wealth or glory, said Luckie, a junior majoring in both genetics and biochemistry. It takes passion to stick it out and establish yourself. Without passion and also curiosity you can become disheartened by a lot of the extraneous hurdles that surround science, whether its bureaucracy or simply failed experiments.

The Barry Goldwater Scholarship and Excellence in Education Foundation awarded 240 scholarships for the 2017-18 academic year to undergraduate sophomores and juniors from the United States. An additional 307 nominees received honorable mentions. The scholars were selected from a field of 1,286 students nominated by campus representatives from among 2,000 colleges and universities nationwide, according to a Goldwater Foundation media release.

Caitlin Seluzicki is a junior majoring in microbiology. I think we are driven by the passion to want to accomplish something that is going to help people, she says. Image Credit: Caitlin Seluzicki

I was very honored and very shocked to open the email that told me I had been awarded the Goldwater Scholarship, said Seluzicki, who plans to pursue a Ph.D. or degree in medicine and doctorate in developmental neuroscience. I really appreciate all the opportunities Ive received here at Clemson. My mentors have had a lot of faith in me and it feels great to show them that their faith was well-placed.

Its definitely very validating to see the accumulation of my research turn into something official like this award, added Zielinski, who will pursue a Ph.D or MD-Ph.D in cancer cell differentiation or drug resistance. It makes me want to continue onward with renewed energy and an even greater sense of purpose.

David Feliciano, assistant professor and researcher in the College of Sciences department of biological sciences, has worked with Seluzicki since her freshman year.

During her time at Clemson, Caitlin hasdevotedmore than 1,200 hours of work in my laboratory, said Feliciano, who received a $442,000 National Institutes of Health (NIH) grant in 2016 to study the molecular causes of autism and epilepsy.Caitlin is a brilliantstudent with anunrelenting work ethic. She has an outstanding trajectory that is forged by her passion for knowledge. She is a calm and steady force whose work ethic, intelligence and kindness are an inspiration to everyone around her. Its the combination of these characteristicsand her contributionsto the field of neuroscience that make her an ideal Goldwater Scholar andfuturescientist.

Jessica Zielinski is a junior majoring in biochemistry. As a scientist, you get out what you put in, she says. Image Credit: Jessica Zielinski

Lukasz ,assistant professor and researcher in the College of Sciences department of genetics and biochemistry, has worked with Zielinski since Spring 2016.

I am very fortunate that Jessica decided to join my laboratory. Jessica is a born leader. She is a fast learner and fearlessly navigates new experiments and techniques. She is a natural scientist, said Kozubowski, who conducts NIH-funded research aimed at elucidating mechanisms of virulence of human fungal pathogens.

Jessica strives for perfection and is relentless in her pursuit to understand the cause of an unexpected result. Her innate curiosity and genuine passion for science make her an ideal candidate for this prestigious award, and I have no doubts that Jessica will go on to make significant contributions to science in her future.

Kerry Smith, professor in the College of Sciences department of genetics and biochemistry, said that Luckie is a student who has already matured well beyond her years.

When discussing science with Bridget, it is very easy to forget that she is a junior and not a second- or third-year Ph.D. student, said Smith, who is director of Clemsons Eukaryotic Pathogens Innovation Center. It is stunning how well-read she is, especially in terms of the scientific literature. She has all of the tools intelligence, desire and curiosity necessary to make significant scientific contributions in her career and eventually lead her own research lab.

Bridget Luckie is a junior majoring in both genetics and biochemistry. My generation will represent the future, and Im very excited to see what we come up with, she says. Image Credit: Bridget Luckie

During a recent get-together, Clemsons three young scientists made it clear that they are not deterred by a growing concern that science is taking a back seat to political machinations. Instead, they refuse to back down to this or any challenge.

I think its really valuable to bridge the gap between the scientific community and the general public, said Seluzicki, whose hometown is Baltimore. Scientists need to demonstrate the value of our pursuits and the implications of what were pursuing and the implications if we stop pursuing.

We, as future scientists, can take an active role in the policy that influences the research community, said Zielinski, who was born and raised in Clemson Even now as students, I think advocacy and public outreach are ways we can help the field grow.

Scientists have the ability to recognize whats wrong and then fix it, saidLuckie, whose hometown is Fort Mill. This is what ignites the fire in me. My generation will represent the future, and Im very excited to see what we come up with.

END

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Three College of Science students honored by Barry Goldwater Scholarship Foundation - Clemson Newsstand

Chemistry and Biochemistry Symposium to Feature NASA Speaker and Poster Session – Seton Hall University News & Events

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Tuesday, April 11, 2017

By Nicholas Snow

The Department of Chemistry and Biochemistry is proud to present its 22nd annual departmental symposium and poster session in conjunction with the Petersheim Academic Exposition on Tuesday evening April 18, 2017.

The symposium will include a lecture in the Rose Mercadante Seminar Series by Dr. Melissa G. Trainer of the Robert Goddard Space Flight Center, National Aeronautics and Space Administration entitled "Chemistry on Mars: The Search for Habitable Environments with Curiosity" at 5:45 PM in the Helen Lerner Amphitheater, McNulty Hall, Science and Technology Center, Seton Hall University.

Following the lecture, a poster session featuring the research of 50 undergraduate and graduate students in the Department of Chemistry and Biochemistry will be held at 7:00 PM in the Mary Ann and Pat Murray Atrium in McNulty Hall. All members of the University Community and friends of the Department of Chemistry and Biochemistry are welcome to attend the lecture and poster session.

Following on decades of exploration of Mars, our knowledge of our neighboring planet has advanced well beyond observations of canals to the comprehensive characterization of surface topology and regional mineralogy. There are clear lines of evidence for past liquid water and a complex climate history. Yet some of the fundamental questions remain: Was there ever life on Mars? Could there have been life on Mars? The Curiosity rover carries the most advanced analytical laboratory sent to another planet, and over the past four and half years the mission has performed a detailed in situ investigation of Gale Crater. The Sample Analysis at Mars (SAM) instrument suite in particular has quantified geochemical indicators that demonstrate the environment could have supported life, and has achieved detection of the first organic molecules on Mars. Atmospheric measurements by SAM have identified signatures of planetary change over billions of years and monitored modern activity. This presentation will recount the most important findings on the chemistry of Mars to date, and will discuss the implications for our understanding of whether the red planet was ever habitable.

Dr. Trainer is a Research Space Scientist in the Planetary Environments Laboratory at NASA Goddard Space Flight Center, with research interests in the composition of planetary atmospheres and the production of organic organic molecules and aerosols via atmospheric synthesis.

Dr. Trainer has spent more than a decade characterizing the properties of Titan and early Earth aerosol analogs. Her publications on this topic include chemical, optical, and isotopic characterizations of these analogs produced via electric discharge and photochemical irradiation, with recent emphasis on the elemental composition, nitrogen activation, and the influence of trace species such as benzene.

Dr. Trainer is a science team member on the Sample Analysis at Mars (SAM) experiment aboard the Mars Science Laboratory Mission's Curiosity Rover, with a focus on the compositional measurements of the Mars atmosphere. She has led the campaign to conduct the first in situ multi-year study of the seasonal variations of the composition of the Mars atmosphere through surface mass spectrometry measurements. She also worked with the SAM team to make the first measurements of the full suite of xenon isotopes in the Mars atmosphere as well as the inventory of other noble gases.

The Department of Chemistry and Biochemistry offers BS, MS and PhD degrees with specializations in all areas of chemistry. Our unique research environment, including traditional full-time students and part-time students is designed to foster collaborations with industry and colleagues in other disciplines. The Rose Mercadante Seminar Series is named for Rose Mercadante, the departmental secretary for over 40 years, in honor of our alumni, her "boys and girls".

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Chemistry and Biochemistry Symposium to Feature NASA Speaker and Poster Session - Seton Hall University News & Events

Chemistry student wins Iota Sigma Pi award – Huntington Herald Dispatch

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HUNTINGTON - Whether she is winning prestigious awards from the national honor society for women in chemistry or traveling across the U.S. to present her biochemistry research, Amanda Smythers is setting the standard for what it means to be a young scholar.

Smythers, a 27-year-old biochemistry student from Huntington, has received Iota Sigma Pi's Members At Large Re-entry Award, which recognizes excellence in chemistry achieved by a woman at the graduate or undergraduate level, according to a news release from the university.

In addition to receiving the award, she was invited to present her research at the 2017 Posters on the Hill, a competitive event held in Washington, D.C. The program gives students the opportunity to showcase their research to congressional members, meet with their representatives and learn about advocacy for undergraduate research. Out of hundreds of applications to the program, only 60 are chosen to present their research.

"It really is such a great opportunity to have our research shown on a national platform," Smythers said in the release. "Since they take so few abstracts, I did not think I stood much of a chance, but here we are. It is so important for our national leaders to understand the importance of our work and recognize the quality of research Marshall University contributes to the field."

As a non-traditional student who returned to Marshall with no intention of establishing a career in research, Smythers said she was initially surprised when she found a real passion in chemistry.

"I am excited to share my experiences and show people how great the chemistry program is here. In addition to the funding I received from NASA, I received two scholarships from our chemistry department as well as the summer research fellowship. They have also funded me to travel to a variety of conferences around the U.S., including conferences in Cincinnati, San Diego, Philadelphia and Chicago," Smythers said.

While in Washington, D.C., for the 2017 Posters on the Hill event, Smythers will present research that focuses on making microalgae a more efficient stock for biofuel production. Smythers and her faculty mentor, Dr. Derrick Kolling, will have the opportunity to present their research April 26.

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Chemistry student wins Iota Sigma Pi award - Huntington Herald Dispatch

Chlortetracycline Hydrochloride Market 2017 Fujian Fukang Pharmaceutical, Pucheng Chia Tai Biochemistry – TechAnnouncer (press release) (registration)…

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Major Companies Covered in this report:- Fujian Fukang Pharmaceutical Pucheng Chia Tai Biochemistry

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UC scientist finds new solution to fight superbug infections – WCPO Cincinnati

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CINCINNATI It only took years of studying, getting his PhD and completing post-doc positions at two universities for Daniel Hassett to land a job that eventually led him to discover a drug that can fight superbug infections resistant to antibiotics.

No, it's not a cure for coronavirus, but it's pretty darn cool. At least, that's what Hassett, a professor in the UC Department of Molecular Genetics, Biochemistry and Microbiology, will tell you.

Its actually beyond a big deal -- Its huge, Hassett said while standing in the laboratory where he made this discovery. The real plus of it is that it not only kills all of bacteria, but it kills the ones that are the most antibiotic-resistant bacteria.

Paola Suro

The bacteria he has been fighting makes about 2.8 million people in the United States sick every year and kills more than 35,000 people, according to the Centers for Disease Control and Prevention.

In very, very severe infections where the bugs are resistant to everything, its virtually impossible for them to become resistant to my drug, he said. Its not only anti-microbial, it has powerful wound-healing capacity as well.

Paola Suro

The invention called AB569 is composed of ingredients pacified nitrite and ethylenediaminetetraacetic acid and kills one of the most serious bacterium (Pseudomonas aeruginosa) that is resistant to several drugs and virulence.

Even if it positively affects one patient with a certain anomaly, just one, its a good thing, Hassett said. But we think its going to be pretty ubiquitous as far as this treatment goes.

Paola Suro

At first, researchers found AB569 could potentially treat antibiotic-resistant organisms that cause pulmonary infections in people with cystic fibrosis and chronic obstructive pulmonary disease, among others. Since then, Hassett said he has found it could do more than that, including treat urinary tract disorders, heal wounds, and even treat diabetes.

AB569 kills these pathogenic bacteria by targeting their DNA, RNA and protein biosynthesis as well as energy and iron metabolism at concentrations that do not harm human cells, he explained to UC Health researchers. These were tested in laboratory mice and humanized cells. Our data implicate that AB569 is a safe and effective means that could be applied to eradicate these superbugs.

Pseudomonas aeruginosa was placed in the lungs of lab mice for five days. It's considered one of the six ESKAPE pathogens, which, according to Hassett, are among the most resistant and deadly to humans. It includes Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp. These pathogens can result in infections and illnesses like pneumonia and MRSA.

Paola Suro

His discovery was patented in March 2018, but now he is working on getting more funding and support to push this discovery further.

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UC scientist finds new solution to fight superbug infections - WCPO Cincinnati

UVM Appoints New Dean of Agriculture and Life Sciences – UVM News

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University of Vermont Provost and Senior Vice President Patricia Prelock today announced the appointment of Leslie V. Parise, Ph.D., as dean of the College of Agriculture and Life Sciences (CALS).

Parise has built a long and successful career at the University of North Carolina-Chapel Hill (UNC-CH), where she rose through the ranks from assistant to full professor. For the past decade, Parise has served as the chair of the Department of Biochemistry and Biophysics, which currently ranks fifth in the United States for National Institutes of Health-funded biochemistry departments.

Dr. Parise is a strong proponent of translating research to benefit society, said Prelock. She impressed the search committee with her understanding of the importance of UVMs land-grant mission, and the critical role CALSand UVM Extensionhave played in advancing this mission. She has a track record of working with faculty to promote inventions, patenting, and licensing agreements. And her entrepreneurial mindset resonates with the innovative spirit so central to our UVM community. I have no doubt that Dr. Parise will be an exceptional leader and member of our community.

President Garimella said of her appointment, We are delighted that Dr. Leslie Parise is joining the University of Vermont as dean of the College of Agriculture and Life Sciences. She brings an impressive skillset to the university: great prowess in basic and translational research, longtime success promoting entrepreneurship and technology transfer, a commitment to student success, and a proven track record as a leader. We very much look forward to welcoming her to the UVM community.

Parise said she is honored to join the UVM community. CALS and UVM Extension play an incredibly important role in demonstrating the power of UVMs land-grant mission, she said. I look forward to meeting and working closely with the world-class faculty, staff and students of UVM, along with residents of Vermont. Finding ways to further engage our constituents to strategically maximize the educational, research and service missions of CALS, and to increase its visibility across the state and beyond will be among my priorities. I look forward to further positioning CALS as a microcosm for positive global impact.

Widely recognized for cardiovascular and cancer research, Parises work has been continuously funded, including more than $14.5M from the NIH. She is also a strong advocate for faculty and student advancement. As department chair at UNC, she worked with faculty, students and postdoctoral fellows to reinvigorate programs through a range of approaches including enhanced internal communication and planning, and increased mentoring.

Parise helped faculty maintain and grow funding through partnerships across campus and with neighboring institutions to facilitate greater investment from foundations and government agencies such the Keck Foundation, American Heart Association, National Institutes of Health and the National Science Foundation. She also facilitated partnerships with neighboring institutions to stimulate investment in a highly transformative technology for solving molecular structures called cryo-electron microscopy.

In 2017, Parise was elected Chair of the Faculty at UNC-CH, a role she held until May 2019. In this capacity, she represented all 3,800 faculty of the UNC-CH campus, interacting closely with the chancellor, provost, deans and faculty from within the university, as well as UNCs Board of Trustees, system president, and a faculty assembly from across the states 17-campus system. She has worked closely on issues ranging from curriculum changes, to budget models, to advancing diversity.

Parise will join UVM on May 15.

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UVM Appoints New Dean of Agriculture and Life Sciences - UVM News

Biochemistry Analyzers Market Reprt Impressive Growth, Industry Size, Key Players And Forecast 2020 To 2027 – TechNews.mobi

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Biochemistry Analyzers Market Reprt Impressive Growth, Industry Size, Key Players And Forecast 2020 To 2027 - TechNews.mobi

IISc.s biochemistry department turns 100 – The Hindu

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The Department of Biochemistry of the Indian Institute of Science (IISc.) stepped into its centenary year in 2020. Established in 1921, it is said to be one of the oldest departments not only in India, but in all of Asia. Around 850 students have graduated from the department so far.

P.N. Rangarajan, Chairperson, Department of Biochemistry, told The Hindu that the major achievement has been its students, many of who are now leaders in industry and academia. One of them J. Padmanabhan alumni and faculty became the director of IISc. M.R.S. Rao went on to become the president of the Jawaharlal Nehru Centre for Advanced Scientific Research, and Ram Rajasekharan became the Director of CFTRI-Mysuru, he said.

The department has planned a major conference and alumni reunion in December, as well as a centenary lecture series that will be held almost every month. On the IISc.s Open Day on Saturday, it is organising an exhibition highlighting its past and current activities.

Prof. Rangarajans own research has led to the development of the hepatitis B vaccine. At least four vaccines are currently in the market. The hepatitis B component in these vaccines came from the lab of the Department of Biochemistry, he added.

In a recent issue of the journal Current Science, Prof. Rangarajan lists out the progression of research in the department. This includes research of societal relevance in the early years which resulted in the development of methods for conversion of municipal waste into organic manure and fluoride removal from drinking water, to name a few.

The article makes note of key contributions in basic research such as the identification of yeast chromosomes and nuclear membrane.

Ongoing research

At present, a novel drug combination for extremely drug resistant and multi-drug resistant TB, as well as new blood-based biomarker signatures of host genes for diagnosis of tuberculosis and for detecting response to anti-tubercular therapy are being developed, he told The Hindu. A novel inhibitor of DNA repair enzyme called SCR7 has also been developed in our laboratory. It has the potential to develop as a cancer drug, said Prof. Rangarajan.

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IISc.s biochemistry department turns 100 - The Hindu

Automated Biochemical Analyzers Market likely to touch new heights by end of forecast period 2020-2025 – Express Journal

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Global Automated Biochemical Analyzers Market report provides an in-depth analysis of the overall market over a period from 2020-2025. The report focuses on major key players, production details, their application, and countries and also analyzes the global and key regions market potential and advantage, opportunity, and challenge, restraints, and risks.

A brief overview of how the Automated Biochemical Analyzers market will perform over the projected timeframe has been given in the report. Also, details about the driving aspects influencing the market dynamics as well as the growth rate that the industry is expected to register over the forecast duration have been delivered. Additionally, the Automated Biochemical Analyzers market report also delivers a brief of the challenges that this vertical is defined by, in conjunction with the growth opportunities that this business space is remnant of.

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Automated Biochemical Analyzers Market Segmentation: USA, Europe, Japan, China, India, South East Asia.

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Automated Biochemical Analyzers Market likely to touch new heights by end of forecast period 2020-2025 - Express Journal

Catch and Release: MTU Biochemists Purify Proteins with a Fishing Technique – Newswise

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Newswise Biochemists developed a catch and release technique to find the specific protein theyre fishing for.

The technique is explained in a new paper published in the Journal of Biological Chemistry. A team of biochemists from Michigan Technological University, including students, did the research, which is led by Tarun Dam, associate professor of chemistry.

Protein purification is a multibillion-dollar industry, Dam said, explaining that proteins are important for studying everything from cancer to allergies to vaccines. Unless you purify a protein, you dont know what it can do. We set out to improve that process.

Go FishFor Proteins

Much like fishing, Dam and his teams technique comes down to selecting the right lure and knowing the habits and habitat of what theyre baiting. They call their system CaRe, short for capture and release, and it follows four steps.

First, the team has to capture the protein theyre looking for. They do this by picking the lure: The tackle box is full of ligands, which are molecules with pincer-like arms that can bind proteins between the prongs. Much like fish that prefer different flies, lures or live bait, different proteins bind better with different ligands.

The hook needs to be a specific capturing agent, Dam explained, adding that the second step is to isolate the bound protein. Now we need the centrifuge. Once the protein is caught, the molecules weight becomes heavier, so they come down in solution.

The third step is to remove the isolated ligand-protein complex much like getting the fish into the boat and the fourth step is to get the hook out and separate the ligand and protein. Once separated, the protein stands alone, a purified end product.

No technique is 100% perfect, Dam said, noting that isolating low levels of a protein is akin to trawling for walleye where the sunfish hang out. Also, just like real lures, some proteins are picky and some ligands attract everything; a challenge and delight that keeps many people in waders and lab coats.

What we are most excited about is the simplicity of the technique, Dam said.

CaRe can isolate and separate out proteins in a day or two compared to the greater expense in both time and cost of current protein purification systems.

Glycoproteins, Cancer and Immunotherapy

Dam and his Michigan Tech collaborators, notably research assistant professor Purnima Bandyopadhyay, were able to develop CaRe because of the nature of the proteins. Alongside carbohydrates and fats (lipids), proteins are an important building block of living organisms.

About 60% of proteins are glycoproteins, meaning they have a sugar-based chain attached to them, and for decades, researchers thought the chains were junk structures. But as often happens in research over time, the sugary chains proved to be a key part of how proteins interact with their environment and the cells around them.

In his primary research, Dam explores a specific proteins interactions. Galectin-3, or simply Gal-3, is an important biomarker for thyroid cancer and a multitasking protein. Bandyopadhyay makes recombinant Gal-3 and its mutants in the lab. As Dam developed his Gal-3 research and needed to screen different proteins, he was set back by the cost and cumbersome processes of protein purification. So, he asked Bandyopadhyay, can we go fishing?

In addition to his own work, Dam is excited to see other labs apply the CaRe technique. It simply requires basic equipment and the chemistry equivalent of old fishing wisdom to know what lure catches what. Whether its sorting out cancer-related glycoproteins and proteins like Gal-3 or purifying proteins for immunotherapy treatments, luring the right molecules becomes as simple as catch and release fishing.

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Catch and Release: MTU Biochemists Purify Proteins with a Fishing Technique - Newswise