Teen on the mend after colitis battle – Prince George Citizen

After being diagnosed with ulcerative colitis at seven years old, one local teenager is happily in remission after years of treatment.

The journey to get to that point wasn't an easy one and required help from many sources.

Kalena needed specialized treatment that included attending at BC Children's Hospital several times a year.

Kathy Samaai, Kalena's mom, said it was a scary time for the family when Kalena was first diagnosed on her seventh birthday.

Ulcerative colitis is rarely diagnosed in someone her age.

The trouble started about six months before the diagnosis when Kalena started getting fevers for no apparent reason. She was in pain and began having bloody stool that prompted her family to take her to the local emergency room on a regular bases.

Kalena was only six years old and needed specialized tests like an endoscopy and a colonoscopy.

Those procedures are not done in Prince George in children and the she needed to go to Vancouver.

"Its a 12-hour drive, Samaai said. Our car wasnt new and I was working full time and worried about missing work.

Once diagnosed the proposed treatment options were not ideal and while one involved an invasive surgery that involved installing a stoma bag that sits outside the body, the other was a biochemical infusion that comes with risk of side effects.

"Kalena always liked to swim, especially synchronized swimming and just loves the water so wearing a bag was not ideal," Samaai said.

As a family it was decided that the biochemical infusions would be used for treatment, as long as Kalena's system would accept it.

"But of course with the biochemical comes side effects like a sensitivity to sun, for example," Samaai said. "So she had to stay out of the sun or cover up really well to avoid burning because that could lead to cancer."

The treatment was administered at BC Children's Hospital and would continue every eight weeks for the foreseeable future.

The trips by car down south were all right until winter hit and that was when hospital staff told Samaai about Hope Air to help with flights to and from treatments.

When I called Hope Air it was a good experience, Samaai said, The staff was easy to connect with and our flight was booked. That was in 2012 and we have been flying with Hope Air ever since. We just couldnt have done it without Hope Air.

Before that first trip. Kalena had never even been on a plane. She and her mother have made 75 trips with Hope Air to date.

Kalena is now 16, currently in remission and feeling good.

She is a volleyball player and a swimmer working on getting her lifeguard certification. Kalena wants to go into medicine when she's older and once the coronavirus pandemic is over she looks forward to life guarding to earn money for her tuition.

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Teen on the mend after colitis battle - Prince George Citizen

We need a new mindset on substance use, and stop treating addiction as criminal activity – Lansing State Journal

Maxine Thome, guest writer Published 4:37 p.m. ET Oct. 28, 2020 | Updated 5:08 p.m. ET Oct. 28, 2020

Maxine Thome(Photo: Courtesy photo)

In my 40 years of working in the field of social work, Ive been an inpatient therapist in a state-run psychiatric facility, directed behavioral health for a family practice residency program in Saginaw, ran a child sexual abuse program, worked with women sex workers and created a program to help people living with HIV-AIDS that eventually morphed into the Lansing Area AIDS Network. Today, I run my own private practice.

As I reflect on the populations Ive served from family practice to sexual abuse to HIV-AIDS theres a common thread: substance use disorder.

Im not implying everyone in those categories uses substances, but I have experienced the disproportionate and devastating impact of substance use within disenfranchised populationsespecially lower socioeconomic groupsbecause of lack of access to care, bias, hatredand biochemical predisposition.

We must, as a society, shift our mindset away from viewing substance use disorder as criminal activity and toward treating it as the biochemical malfunction science is proving it to be. In doing this, we will protect vulnerable populations from further imprisonment, trauma and disenfranchisement.

This new mindset includes replacing imprisonment as a sole solution to substance use with prevention resources like counseling, social workers and education programs, within communities to stop the problem before it occurs.

In January, the Michigan Joint Task Force on Jail and Pretrial Incarceration recommended to divert people with behavioral health needs away from the justice system citingstrain on county jail resources, delay restoration in felony casesand that it often leads to further mental health deterioration while in jail.

If I, a white, educated woman, had a substance use disorder (addiction), my insurance would cover my admission into a rehab program. If a poor person who didn't have adequate insurance and got arrested as a result of something fueled by substance use, they likely wouldnt have the same access to treatment. Those odds increase if it is a person of color.

Prison is not a place for people who are drug-dependent.

Addiction whether it's alcohol or other substances is a biochemical malfunction. So it's the biochemical need, the physiological need that exists. And that's why we refer to substance use as an illness or a disease. There's also a need to use substances because of stress, but I firmly believe the addictive component is biochemical and should be treated as such.

Clinical social workers are among the nations largest providers of mental health services, including substance use treatment. There were 2,729 deaths from drug overdoses in the state of Michigan in 2017 more than from car accidents according to state government data.

With help from the Michigan Health Endowment Fund and key statewide organizations, were providing a substance use disorder training to effectively increase the reach and impact of Michigan social workers on those suffering from substance use disorder in schools, hospitals, shelters, low socioeconomic communities and beyond. But, it will not happen without a societal mind shift of knowledge and compassion around substance use disorder.

Maxine Thomeis the executive director of the National Association of Social Workers - Michigan.

Read or Share this story: https://www.lansingstatejournal.com/story/opinion/contributors/viewpoints/2020/10/28/changing-mindset-drug-abuse-treatment-and-substance-use/3726909001/

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We need a new mindset on substance use, and stop treating addiction as criminal activity - Lansing State Journal

The benefits of Vitamin D in the COVID-19 pandemic: biochemical and immunological mechanisms – DocWire News

This article was originally published here

Arch Physiol Biochem. 2020 Oct 8:1-9. doi: 10.1080/13813455.2020.1826530. Online ahead of print.

ABSTRACT

In December 2019, a new infectious complication called CoronaVirus Infectious Disease-19, briefly COVID-19, caused by SARS-COV-2, is identified in Wuhan, China. It spread all over the world and became a pandemic. In many individuals who had suffered SARS-COV-2 infection, cytokine storm starts through cytokine overproduction and leads to Acute Respiratory Syndrome (ARS), organ failure, and death. According to the obtained evidence, Vitamin D (VitD) enhances the ACE2/Ang(1-7)/MasR pathway activity, and it also reduces cytokine storms and the ARS risk. Therefore, VitD intake may be beneficial for patients with SARS-COV-2 infection exposed to cytokine storm but do not suffer hypotension. In the present review, we have explained the effects of VitD on the renin-angiotensin system (RAS) function and angiotensin-converting enzyme2 (ACE2) expression. Furthermore, we have reviewed the biochemical and immunological effects of VitD on immune function in the underlying diseases and its role in the COVID-19 pandemic.

PMID:33030073 | DOI:10.1080/13813455.2020.1826530

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The benefits of Vitamin D in the COVID-19 pandemic: biochemical and immunological mechanisms - DocWire News

University Sees Record-Breaking Year In Grant Funding News Center – Montclaire News

October 7, 2020

Across disciplines, faculty have received more than $22M in grants to further programs and research

Posted in: Homepage News, Research, University

Montclair State faculty, leading educational programs and research in multiple disciplines across the University attracted a record-breaking $22.4 million in external grant funding for fiscal year 2020, shattering the FY 2019 record of $17.9 million.

Researchers in fields as diverse as biochemistry, educational leadership, environmental science, social work, modern languages and psychology are investigating everything from STEM education for Hispanic students and their families to school security climate, neurotransmitter functionality, K-12 education inclusion for children with disabilities, enzyme inhibitors for memory loss and so much more.

Funders include a growing and varied list of federal, state, local and private sponsors including the National Science Foundation, National Institutes of Health, U.S. Department of Education and National Institute of Justice.

Ted Russo, director of Research and Sponsored Programs, reports the dollar amount is also nearly double what the University attracted just eight years ago, in FY 2012. Grants have seen steady growth each year during the last decade, and the University is off to a strong start for FY 2021 with $6 million in new funding announced in just the first few months.

Vice Provost for Research Scott Herness points out that the record breaking year coming after our R2 status, really solidifies our standing as a public research institution.

These grants show that our University is headed in exactly the right direction, increasing its research endeavors and our funding portfolio, says Herness. Its great for our faculty and for our students, who are getting lots of opportunities to participate in research.

Included in the FY 2020 funding:

In the first few months of FY 2021, the University has received approximately $6 million in new funding, including:

Story by Staff Writer Mary Barr Mann

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University Sees Record-Breaking Year In Grant Funding News Center - Montclaire News

October: flf-award | News and features – University of Bristol

Four Bristol researchers have been awarded UK Research and Innovation's (UKRI) prestigious Future Leaders Fellowships. The awards, designed to establish the careers of world-class research and innovation leaders across the UK to help them tackle major global challenges, are announced today [15 October] by Science Minister Amanda Solloway.

The initiative will see 101 fellows based at UK universities and businesses supported through an investment of 109 million.

Announcing the successful fellows at todays Future Leaders Conference, Science Minister Amanda Solloway said: We are committed to building back better through research and innovation, and supporting our science superstars in every corner of the UK. By backing these inspirational Future Leaders Fellows, we will ensure that their brilliant ideas can be transferred straight from the lab into vital everyday products and services that will help to change all our lives for the better.

UK Research and Innovation Chief Executive, Professor Dame Ottoline Leyser, said: Future Leaders Fellowships provide researchers and innovators with freedom and support to drive forward transformative new ideas and the opportunity to learn from peers right across the country.

"The fellows announced today illustrate how the UK continues to support and attract talented researchers and innovators across every discipline to our universities and businesses, with the potential to deliver change that can be felt across society and the economy."

Four Bristol researchers are among the recipients of UKRI Future Leaders Fellowships. These include:

Dr Hannah Griffiths from Bristols School of Biological Sciences who will explore how large above-ground mammals, such as deer, as well as tiny invertebrates and microbes under the soil, impact forest growth providing new knowledge that will inform efforts to increase biodiversity and combat climate change.

Soil communities are extremely complex and diverse, with millions of species and billions of individuals living within a single ecosystem. However, because life in soil is so small and numerous, studying below-ground food webs is extremely challenging and time consuming. Therefore, an important outcome of this work will be the use of cutting-edge genetic sequencing techniques to determine, for the first time, how the diversity of these difficult to study organisms influences carbon sequestration and therefore climate change mitigation strategies. The study will help us understand and mitigate the consequences of declines in global biodiversity for the ecosystem services that support humanity and generate data that will help manage the restoration of forests to reverse the decline in biodiversity and help mitigate global warming.

Dr Anya Skatova, a Turing Fellow and behavioural scientist at Bristol Medical School (Population Health Sciences) will work on realising the value of transaction data to improve population health. Her fellowship will question whether shopping history data, such as recorded through supermarket loyalty cards, can be used in a positive way to support health research and the development of new interventions. Dr Skatova, who is currently based in Bristols School of Psychological Science, will link retail loyalty card datasets with rich medical, genetic, early life environment and other records collected by the Avon Longitudinal Study of Parents and Children (ALSPAC). This will allow to create a transaction data linkage framework for other longitudinal cohorts and population health more broadly. Further, the fellowship will establish the feasibility of novel ways of assessing both health outcomes and associated lifestyle choices through objective measures of real-world behaviours reflected in retail shopping history data,and apply new methods on reproductive health domain.

The ultimate goal of the study is to put large commercial datasets such as shopping history data at the service of the public healthcare through contributing to early detection of diseases, developing and testing targeted interventions, and contributing to the evidence-based healthcare and health research.

Dr Siddhartha Kar, a cancer epidemiologist at the Bristol Medical School will study how a wide range of everyday factors, such as exercise and diet, as well as the human bodys physiology and biochemistry relate to the molecular characteristics of tumours in cancer patients. Dr Kar will then map how these tumour molecular characteristics, in turn, affect survival after a diagnosis of cancer. Some of these everyday factors, particularly those associated with lifestyle, are modifiable through public health interventions. Other physiological and biochemical measures, such as the levels of specific proteins or cholesterol in the blood, and the tumour molecular characteristics themselves, may be amenable to medical treatment. By establishing the causal chain from these factors or measures to tumour molecular features to cancer progression, Dr Kars work will inform the development of novel approaches to cancer prevention and therapy.

Dr Joshua Silverstone, a Leverhulme Early Career Fellow and member of the Quantum Engineering Technology (QET) Labs in the Department of Electrical and Electronic Engineering will develop the optical-electrical systems that are essential for realising the coming quantum revolution. The development of quantum technologies will change how we collect, compute, and communicate information in our everyday lives. Using long-wavelength single photons, particles of light, together with tightly integrated electronics, Dr Silverstone and his team hope to overcome the barriers to building big quantum technology, making it useful in the wider world.

UKRIs initiative aims to support the creation of a new cohort of research and innovation leaders who will have links across different sectors and disciplines. Awardees will each receive between 400,000 and 1.5 million over an initial four years. The grant supports challenging and novel projects, and the development of the fellows career. The funding can also used to support team members, their development, and pay for equipment and other needs.

The Future Leaders Fellowships scheme, which is run by UK Research and Innovation, will recognise up to 550 individuals with a total investment of 900 million committed over 3 years. The scheme helps universities and businesses in the UK recruit, develop and retain the worlds best researchers and innovators, regardless of their background. They can apply for up to 1.5 million to support the research and innovation leaders of the future, keeping the UK at the cutting edge of innovation. Each fellowship will last four to seven years.

Round six of the Future Leaders Fellowships is currently open to applications. See: http://www.ukri.org/funding/funding-opportunities/future-leaders-fellowships/how-to-apply/

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October: flf-award | News and features - University of Bristol

Biochemical Oxygen Demand (BOD) Analyzer Market 2020: Global Industry COVID-19 Impact on Size, Growth Research, Share, Segmentation, Total Revenue,…

Biochemical Oxygen Demand (BOD) Analyzer Market Research Report estimate the size of the market for 2020 and project its growth by 2025. It provides a detailed qualitative and quantitative analysis of the Biochemical Oxygen Demand (BOD) Analyzer market. And collect useful data for this extensive, commercial study of the Biochemical Oxygen Demand (BOD) Analyzer market. The global Biochemical Oxygen Demand (BOD) Analyzer report is a basic hold of information, essentially for the business executives.

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Take-home labs and virtual dissections: How the science courses are adjusting – The Scout

Labs have gone hybrid as classes are in person or remote. Photo by Morgan Patrick.

One of the biggest shifts as college and the COVID-19 pandemic collided may have been in the sciences, where a hands-on curriculum plays a big role in student academics.

This past summer, a team of about 40 professors from all departments across campus had meetings to discuss virtual learning and to determine how much face-to-face interaction would be necessary.

In biology, all the labs were kept in-person except for the anatomy labs and major level genetics labs. These labs involve dissections, which could prove difficult to continue if the university decided to shut down all in-person classes. Hence, professors deemed it best to keep these labs virtual instead of shifting back and forth, given the uncertain possibilities.

We discovered very quickly that the virtual dissections that are now available are of high quality and were not even available five years ago, said Kelly McConnaughay, biology professor and acting dean of the College of Liberal Arts and Sciences.

Students have responded positively to these online labs.

My lab professor gives us an informative walk through the experiment outlines as we identify the three-dimensional structures of proteins, genetic mutations, etc., said Dainaly Campuzeno, a senior biomedical science and psychology major. Its been a pretty good experience so far, but it definitely does not beat hands-on experience.

Some other labs, like the Science 101 series, provided remote learners with kits to work on experiments from the comfort of their own homes while being challenged to come up with hypotheses and discover ways to either accept or reject them.

In our department, we have never given students cookbook labs, like Mix this with this and pour this, then write this number down, said Sherri Morris, chair and professor of biology and co-director of Bradleys Center of STEM Education. We encourage them to make observations and challenge themselves to have a certain level of engagement.

In the biochemistry department, all senior-level students are taking their labs in-person due to smaller class numbers and lack of remote learners.

The associate professor and chair of the chemistry and biochemistry department, Michelle Fry, said that students who had to quarantine could even make up missed labs after the quarantine period.

The psychology department is offering the behavioral neuroscience lab this semester, both virtually and in-person. The lab includes the dissection of sheep brains. Students learn about the biological basis of behaviors in animals by locating important structures in the brain that are responsible for daily functions. The lab is offered in-person and virtually.

Even though our intent this summer was to be face-to-face during the fall, I dont think we fully grasped the challenges that came with it, like wearing masks and classroom sizes, said Timothy Koeltzow, associate professor and chair of the psychology department.

For virtual learners, a document camera is used to show the dissections while students in the classroom do the brain dissecting themselves in the labs.

There are other internship opportunities through community partnerships offered this semester in the psychology department, which were impacted by the pandemic. Most of the training for those partnerships had to be moved online to reduce contact, as much as possible.

Something good about all of this is that we will be on the other end of this pandemic with a capability to deliver every course in our portfolio online, under the right circumstances, Koeltzow said. This gives us options to engage non-traditional learners or people who almost finished their degree but could not do so, due to other circumstances.

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Take-home labs and virtual dissections: How the science courses are adjusting - The Scout

Walther Cancer Foundation $11 million investment to expand IU-Purdue bioinformatics collaboration – Purdue News Service

October 8, 2020

Nadia Lanman, a research assistant professor in Purdue College of Veterinary Medicine's Department of Comparative Pathobiology and member of the Purdue Center for Cancer Research, plays a key role in the computational bioinformatics program at Purdue University that is supported by the Walther Cancer Foundation. Through computational bioinformatics, Lanman attempts to discover the molecular mechanisms that underlie cancer and that determine the response of patients to chemotherapy. (Photo provided)Download Photo

INDIANAPOLIS AND WEST LAFAYETTE, Ind. - The Walther Cancer Foundation will invest $11 million to advance collaborative cancer research at Indiana University and Purdue University by supporting scientists through bioinformatics an increasingly critical aspect of their work.

Bioinformatics involves managing and analyzing the massive amounts of data generated by scientific research turning data into knowledge that could lead to new cancer treatments.

We hope this gift enables scientists at IU and Purdue to dig more deeply and refine their studies so they can point out new pathways to good patient outcomes in cancer, said Tom Grein, president and CEO of the Walther Cancer Foundation. Sometimes you have so much data, its hard to comprehend where its leading you. I hope the data-driven analysis will uncover nuggets of opportunity that would otherwise never be seen.

Income from the new Walther Cancer Foundation Bioinformatics Fund will continuously support bioinformatics personnel, technology, and other tools shared by the cancer research programs at both universities. In addition, IU and Purdue will make their own investments into the fund.

The Walther Cancer Foundation leadership understands the central importance of data and analytics in developing better treatments and, ultimately, cures for cancer, said IU School of Medicine Dean Jay L. Hess, MD, PhD, MPH.We are tremendously grateful for their support and the confidence they have in our work.

Timothy Ratliff, the Robert Wallace Miller Director of the Purdue Center for Cancer Research, said the latest gift from the Walther Foundation is a continuation of a longstanding collaboration, commitment and investment that will build on the centers success in cancer drug discovery and development and will help sustain the centers computational genomics and bioinformatics core for years to come. "Once again, we are grateful to the Walther Cancer Foundations vision and generosity, which is so important to our research and success. This continuing partnership, plus our own investments and fundraising, will secure what weve already established and enable us to grow into the future."

Kelvin Lee, M.D., named this week as the new director of the IU Melvin and Bren Simon Comprehensive Cancer Center and the H.H. Gregg Professor of Oncology, said having strong capabilities in bioinformatics is essential to cancer research.

The genetic, biochemical, cellular and immune pathways that can lead to cancer are extraordinarily complex and intertwined. Recent cutting-edge advances in technology means that researchers now have unprecedented amounts of data on these pathways, but this seriously challenges our ability to analyze these huge mounds of information to make sense of what is actually going on, Lee said. We are fortunate that the Walther Cancer Foundation understands that breakthroughs require the expertise and the tools, like artificial intelligence, to help us analyze all this data so we can understand whats really important.

This level of collaboration and sharing of a key resource like a bioinformatics core is unusual among a pair of National Cancer Institute-designated cancer centers. But it also reflects the complementary nature of the two institutions.

Purdues Center for Cancer Research is a basic science cancer research center with more than 110 researchers that is a leader in biomedical engineering and cancer drug development.

The IU Melvin and Bren Simon Comprehensive Cancer Center is a comprehensive cancer center with nearly 250 cancer researchers who conduct basic lab work and drug development but who are also engaged in clinical care and population health research.

Each of them has different capabilities, different levels of expertise, different interests, Grein said. But when you get scientists to collaborate, the outcomes are better.

Since its founding in 1985, the Walther Cancer Foundation has invested more than $165 million in cancer-focused medical research and in research and education aimed at supporting cancer patients and their families.

Walther has previously supported cancer bioinformatics at IU and Purdue on a year-to-year basis. This new gift establishes a fund that will ensure the bioinformatics work continues in perpetuity.

The Walther Foundation endowment provides the opportunity to develop the expertise and the tools that are needed to face current and future challenges in biology and the cancer field, said Majid Kazemian, an assistant professor in Purdues departments of Biochemistry and Computer Science. His research focuses on integrating computational and experimental approaches to study pathogen interaction with host cells and immune system in infectious diseases and cancers caused by pathogens.

"The Purdue University Center for Cancer Research has nearly 100 investigators who are actively engaged in understanding molecular mechanisms of various diseases including lung, liver and prostate cancers, many of which have begun to utilize genomics data in their studies, Kazemian said. "Large genomic public data on many diseases generated over the last decade are a treasure trove of unexplored information. Walther Foundation's funds endowment will enable analysis of big data generated by our centers members and collaborators as well as an exploration of growing public genomics data to contextualize and translate our findings."

Less-costly access to bioinformatics expertise and resources enabled by Walther Foundation will open up

Timothy Ratliff, the Robert Wallace Miller Director of the Purdue Center for Cancer Research, works in a lab at the center. (Purdue University photo/John Underwood)Download Photo

new avenues for many of the Purdue center's scientists to broaden the impact and clinical translation of their discoveries, Kazemian said. "It will also encourage our scientists to perform large-scale genomics assays and will foster new collaborations.

Harikrishna Nakshatri, Ph.D., the Marian J. Morrison Professor of Breast Cancer Research at IU School of Medicine, said he relies on bioinformaticians to design experiments, analyze data and assist him in publishing research results more quickly. The Walther Foundation gift supports that very expensive process, and the collaboration means researchers have more bioinformaticians available when they are needed. All of it combines, Nakshatri said, to enable scientists to reach conclusions that have real benefits for patients.

If you really believe in your hypothesis, Nakshatri said, now you have a chance to test it because you are not burdened by the financial aspects.

According to Hess, the new resources will allow IUs partnership with Purdue to continue to improve the health of Hoosiers. We have worked closely for decades, Hess said. This new collaboration in data sciences will accelerate our ability to benefit cancer patients across the state and far beyond.

About the Walther Cancer Foundation

The Indianapolis-based Walther Cancer Foundation is a private grant-making foundation that supports and promotes interdisciplinary and inter-institutional cancer research, both bench and clinical. The clinical research it supports encompasses clinical trials as well as behavioral studies, the latter as part of the foundations commitment to Supportive Oncology. The Walther Foundation has two primary goals: to support cancer research with the aim of discovering better treatments, if not cures, and to develop a comprehensive approach for supporting patients with cancer and their families. Since its founding, the foundation has invested over $165 million cancer-focused research.

Dr. Kelvin Lee, director of the IU Melvin and Bren Simon Comprehensive Cancer Center (Photo provided) Download Photo

About the Purdue Center for Cancer Research

Since 1978, the Purdue University Center for Cancer Research has been a National Cancer Institute-designated basic-research cancer center. Only seven institutions in the United States have earned this title. Being a basic-research center means it does not treat cancer patients directly. Its work focuses on investigating cancers where they begin at the cellular level to investigate the cause of, and cure for, one of the most devastating killers of our time. Doctors and scientists throughout the world use the centers discoveries to develop methods, medicines and medical devices to save and enhance patient lives.

About the IU Simon Comprehensive Cancer Center

The Indiana University Melvin and Bren Simon Comprehensive Cancer Center is home to the cure of testicular cancer, the worlds only healthy breast tissue bank and is just one of 51 NCI-designated Comprehensive Cancer Centers in the nation. The prestigious comprehensive designation recognizes the centers excellence in basic, clinical, and population research, outstanding educational activities, and effective community outreach program across the state. Its physician-scientists have made protocol-defining discoveries that have changed the way doctors treat numerous forms of cancer.

Media contacts: Jim Bush, 765-336-1909, jsbush@purdue.edu

Katie Duffey, 317-278-3630, kaduffey@iu.edu

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Walther Cancer Foundation $11 million investment to expand IU-Purdue bioinformatics collaboration - Purdue News Service

UCI researcher receives NIH Transformative Research Award – UCI News

Irvine, Calif., Oct. 6, 2020 University of California, Irvine biomedical engineer Chang Liu is the recipient of one of nine Directors Transformative Research Awards this year from the National Institutes of Health under its High-Risk, High-Reward Research Program, the agency announced today.

Lius five-year, $8.4 million grant will support a project to develop a system for making antibody generation a routine and widely accessible process.

It is hard to overstate the importance of monoclonal antibodies in the life sciences, said Liu, UCI associate professor of biomedical engineering who also holds appointments in the Department of Chemistry and Department of Molecular Biology & Biochemistry. Antibodies are critical tools in biomedical research and diagnostics, and they are a growing class of therapeutics to combat cancer and pathogens up to and including the virus responsible for COVID-19.

Liu said current methods for making custom antibodies are slow, costly, inaccessible to most researchers and often unsuccessful. His NIH proposal centers on simplifying the process through continuous and rapid evolution of high-quality antibodies requiring only the simple culturing of yeast cells.

He said his autonomously evolving yeast-displayed antibodies technology could have a transformative impact across the biomedicine field by turning monoclonal antibody generation into a rapid, scalable and accessible process where any lab with standard molecular biology capabilities can generate custom antibodies on demand.

We believe this can be achieved by combining our new technology for continuous protein evolution, a yeast antigen-presenting cell that we will engineer, and cutting-edge generative machine learning algorithms for antibody library design, he said.

Liu said that in addition to the continuous directed-evolution techniques that he has invented in his UCI laboratory, the project will rely on antibody design and artificial intelligence expertise provided by his collaborators and co-PIs of the project, Andrew Kruse and Debora Marks at Harvard Medical School.

The project could potentially result in an explosion of crowdsourced antibody sequence data that will train our machine-learning algorithms to design better antibody libraries for our autonomous evolution system, starting a virtuous cycle, he said.

In addition to contributing to cancer and anti-viral therapies, Liu said he and his fellow researchers will attempt to generate nanobodies against biogenic receptors that respond to acetylcholine, adrenaline, dopamine and other neurotransmitters. The goal of this work will be to develop a better understanding of psychopharmaceuticals in neurobiology and addiction.

In the past, the Transformative Research Award has allowed some of the most ambitious and impactful ideas in biomedicine to blossom, and several previous winners are scientific heroes of mine, said Liu. We have big shoes to fill, but we are up to the challenge.

About the University of California, Irvine: Founded in 1965, UCI is the youngest member of the prestigious Association of American Universities. The campus has produced three Nobel laureates and is known for its academic achievement, premier research, innovation and anteater mascot. Led by Chancellor Howard Gillman, UCI has more than 36,000 students and offers 222 degree programs. Its located in one of the worlds safest and most economically vibrant communities and is Orange Countys second-largest employer, contributing $5 billion annually to the local economy. For more on UCI, visit http://www.uci.edu.

Media access: Radio programs/stations may, for a fee, use an on-campus ISDN line to interview UCI faculty and experts, subject to availability and university approval. For more UCI news, visit news.uci.edu. Additional resources for journalists may be found at communications.uci.edu/for-journalists.

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UCI researcher receives NIH Transformative Research Award - UCI News

Faculty and Staff Receive Nearly $9 Million in Grants, Contracts in Q1 – CSUF News

Cal State Fullerton faculty and staff received close to $9 million in funding during the first quarter of the university's 2020-21 fiscal year. Supported projects ranged from developing a robotic aid system for blinded veterans and documenting the experiences of underrepresented women in California agriculture, to funding CSUF's GEAR UP and Upward Bound programs.

Dawn Macy, director of the Center for Internships and Community Engagement: $1,780,840 in total funding

Joshua Bilbrew,director of CSUFs GEAR UP program: $1,116,440 from the U.S. Department of Education in support of Gaining Early Awareness and Readiness for Undergraduate Programs (GEAR UP).

Diana Vasquez, director of CSUF Upward Bound: $728,821 in total from the U.S. Department of Education

David Chenot, professor of social work: $658,279 continuing award from the Health Resources and Service Administration for the Health Careers Opportunity Program.Related: Program Helps Students See the Opportunities inAllied Health Care

Sadeeka Al-Majid, professor of nursing: $650,000 in first-year funding for a $3.25 million grant from the Health Resources and Services Administration for the project "Scholarships for Disadvantaged Students/Enriching Nursing Representation to Impact Community Health."Related: $3.25 Million Grant to Increase Pipeline of Nurses in Underserved Communities

Alyssa Hernandez, director of Educational Talent Search: continuation awards totaling $605,788 from the U.S. Department of Education

Brady Heiner, associate professor of philosophy: $540,218 in total. He received $50,000 from the North Orange County Public Safety Task Force for the "Project Rebound House Initiative, CSUF Year 4" project, and $490,218 from the State of California

Related: Boundless Opportunity: Project Rebound Opens Doors for the Formerly Incarcerated

Stephanie Vaughn, professor of nursing emeritus: $494,061 continuing grant from the Health Resources and Services Administration for the project titled "EMBRACE: Enrichment Markers of Better Relationship, Academics and Cultural Enhancement."Related: EMBRACE Promotes Cultural Sensitivity, Workforce Diversity in Nursing

Nicholas Brubaker, assistant professor of mathematics, and Wylie Ahmed, assistant professor of physics: $364,582 from the National Science Foundation for the project titled "RUI: Active Noise in the Dynamics of Self-Propelled Particles Stochastic Modeling and Experiments."

Gina Passante, associate professor of physics: $347,901 from the National Science Foundation for the project titled "Collaborative Research: Connecting Spins-First Quantum Mechanics Instruction to Quantum Information Science."

Kelvin Billingsley, associate professor of chemistry and biochemistry: $319,500 in continuing funding from the National Institutes of Health for the project titled "Hyperpolarized 13C Probes for Imaging Warburg Metabolism in Cancer."

Joshua Smith, professor of physics: $254,559 in total from the National Science Foundation

Kiran George, professor of computer engineering: $199,211 from the U.S. Department of Veterans Affairs for "Design and Development of a Teach-by-Showing Paradigm-Based Robotic Aid System for Blinded Veterans."

Sara Johnson, professor of anthropology: $150,000 from the U.S. Department of Agriculture for the "U-ACRE Project: Broadening Opportunities for High Impact Service-Learning Experiences in Agroecological Research" project.Related: Lessons From the Lowly Sweet Potato: U-ACRE Researchers Unearth Knowledge and Cultivate Sustainability

Adam Roberts, assistant professor of psychology: $110,985 from the National Institute of Health for the "Mapping Neural Connectivity in Zebrafish Larvae Using a Photoconvertible Protein" project.

Yinfei Kong, associate professor of information systems and decision sciences: $98,632 continuing award as part of a four-year National Institutes of Health grant for the project "Gender Disparities in Access and Engagement In Medication-Assisted Treatment for Opioid Use Disorder" in collaboration with the University of Chicago.Related: Titan Data Scientist to Study Gender Differences inOpioid Treatment

Geoffrey Lovelace, associate professor of physics: $84,668 continuing award from the National Science Foundation for the CAREER project titled "Computational Gravitational-Wave Science and Education."

Zair Ibragimov, professor of mathematics: two awards from University Enterprises, Inc., totaling $82,500 for "CSU-LSAMP 2018-2023." The Louis Stokes Alliance for Minority Participation is a program to increase disadvantaged students' preparedness, persistence and retention in STEM programs.

Adriana Badillo, program director of the Center for Educational Partnerships: $76,621 continuation award from the City of Anaheim for the College Internship Program.

Jocelyn Read, assistant professor of physics: $67,213 from the National Science Foundation for "RUI: Dense Matter and Gravitational Waves: The Coalescence of Neutron Star Binaries."

Michael Boytim, assistant director of the nurse anesthesia program: $44,630 from the Health Resources and Services Administration for the Nurse Anesthetist Traineeships project.Related: Titans Test Use of Anesthesia Machinesas Ventilators for COVID-19 Patients

Danielle Zacherl, professor of biological sciences: $33,304 from Orange County Coastkeepers for the project titled "Newport Bay Living Shorelines Project."

Marcelo Tolmasky, professor of biological science: $24,659 from the San Diego State University Research Foundation for the San Diego-MHRT project.

Natalie Fousekis, professor of history: $24,580 from the U.S. Department of Interior, National Park Service for "Documenting the Experiences of Mexican, Filipina and Chicana Women in California Agriculture."

Jessica Jaynes, assistant professor of mathematics and Valerie Poynor, assistant professor of mathematics: $19,812 from Los Angeles City College for the "STEM Pathways Program Summer Research 2020" project.

Robert Lockie, associate professor of kinesiology: $19,071 from the National Strength and Conditioning Association Foundation for the project titled "The Effects of Structured Strength and Conditioning Programs on Motor Skills, Movement Competency and Physical Fitness of High School Athletes."

Jennifer Burnaford, professor of biological science: $16,238 continuing award from UC Santa Cruz for "Assessment of Rocky Intertidal habitats for the California Marine Protected Area Monitoring Program."

Michael Groves, assistant professor of chemistry and biochemistry: $16,005 in first-year funding of a three-year award from the American Chemical Society for the project titled "Calculating Reaction Barriers for Benzene Hydroxylation to Phenol Using Graphene Based Catalysts."

Dorothy Woolum, professor emeritus of physics: $10,000 from the California Institute of Technology for the project titled "Genesis Samples."

Do Kyeong Lee, assistant professor of kinesiology: $8,820 continuation award from New York University for the "Play and Learning Across a Year" project.

Bo Y. Park, assistant professor of public health: $8,000 from the University of Southern California for "Planning and Engaging in Advance Care for Health (PEACH)."

Contact: Karen Lindell, klindell@fullerton.edu

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Faculty and Staff Receive Nearly $9 Million in Grants, Contracts in Q1 - CSUF News

Should We Be Excited About The Trends Of Returns At Changmao Biochemical Engineering (HKG:954)? – Simply Wall St

If we want to find a stock that could multiply over the long term, what are the underlying trends we should look for? In a perfect world, wed like to see a company investing more capital into its business and ideally the returns earned from that capital are also increasing. Basically this means that a company has profitable initiatives that it can continue to reinvest in, which is a trait of a compounding machine. However, after investigating Changmao Biochemical Engineering (HKG:954), we dont think its current trends fit the mold of a multi-bagger.

If you havent worked with ROCE before, it measures the return (pre-tax profit) a company generates from capital employed in its business. Analysts use this formula to calculate it for Changmao Biochemical Engineering:

Return on Capital Employed = Earnings Before Interest and Tax (EBIT) (Total Assets Current Liabilities)

0.055 = CN36m (CN757m CN107m) (Based on the trailing twelve months to June 2020).

Therefore, Changmao Biochemical Engineering has an ROCE of 5.5%. Ultimately, thats a low return and it under-performs the Chemicals industry average of 11%.

Check out our latest analysis for Changmao Biochemical Engineering

While the past is not representative of the future, it can be helpful to know how a company has performed historically, which is why we have this chart above. If you want to delve into the historical earnings, revenue and cash flow of Changmao Biochemical Engineering, check out these free graphs here.

On the surface, the trend of ROCE at Changmao Biochemical Engineering doesnt inspire confidence. To be more specific, ROCE has fallen from 7.1% over the last five years. And considering revenue has dropped while employing more capital, wed be cautious. If this were to continue, you might be looking at a company that is trying to reinvest for growth but is actually losing market share since sales havent increased.

From the above analysis, we find it rather worrisome that returns on capital and sales for Changmao Biochemical Engineering have fallen, meanwhile the business is employing more capital than it was five years ago. It should come as no surprise then that the stock has fallen 30% over the last five years, so it looks like investors are recognizing these changes. Unless these trends revert to a more positive trajectory, we would look elsewhere.

One more thing to note, weve identified 3 warning signs with Changmao Biochemical Engineering and understanding these should be part of your investment process.

For those who like to invest in solid companies, check out this free list of companies with solid balance sheets and high returns on equity.

PromotedWhen trading Changmao Biochemical Engineering or any other investment, use the platform considered by many to be the Professionals Gateway to the Worlds Market, Interactive Brokers. You get the lowest-cost* trading on stocks, options, futures, forex, bonds and funds worldwide from a single integrated account.

This article by Simply Wall St is general in nature. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned. *Interactive Brokers Rated Lowest Cost Broker by StockBrokers.com Annual Online Review 2020

Have feedback on this article? Concerned about the content? Get in touch with us directly. Alternatively, email editorial-team@simplywallst.com.

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Should We Be Excited About The Trends Of Returns At Changmao Biochemical Engineering (HKG:954)? - Simply Wall St

Scientists develop new tools to study the immune system – Folio – University of Alberta

University of Alberta chemists have developed new tools for studying the human immune system that lay the foundation for research that could improve understanding of cancer and neurodegenerative diseases such as Alzheimers.

Our lab studies sugar-binding receptors called Siglecs that control cells in our immune system, explained Matthew Macauley, assistant professor in the Faculty of Science and Canada Research Chair in Chemical Glycoimmunology. Studying the sugar-binding properties of Siglecs is challenging because these biochemical interactions are weaker than typical protein-protein interactions.

To address this, the research team used a velcro-like effect called avidity to strengthen these interactions, making them easier to study.

These advances are facilitating our understanding of the roles that Siglecs play in neurodegeneration and cancer, said Macauley.

Emily Rodrigues, a PhD candidate in the Macauley laboratory who is supported by an Alberta Innovates Graduate Student Scholarship, led the study.

The tools were designed in a way that would make them compatible with many different methods of testing, including mass spectrometry, explained Rodrigues. This work, done with Professor John Klassen, opens up many new avenues for studying these receptors that were not previously possible.

The research team applied the new tools to examine the sugars recognized by a protein called CD33, a protein Macauley previously studied for its role in Alzheimers disease.

Using these new tools, we were able to clarify the biochemical nature of the sugars recognized by CD33which turned out to be more broad than previously believed, explained Macauley.

Certain people in the population have a version of CD33 that cant recognize sugars, and these individuals have a decreased probability of developing Alzheimers disease. The implications are that interactions between CD33 and sugars are detrimental. Ultimately, a better understanding of the sugars that CD33 recognizes could lead to a strategy for targeting CD33-sugar interactions as a way of treating the disease.

This project is funded by the Natural Sciences and Engineering Research Council of Canada, GlycoNet and Alberta Innovates.

The first study, A Versatile Soluble Siglec Scaffold for Sensitive and Quantitative Detection of Glycan Ligands, was published in Nature Communications. The second, Mass Spectrometry-Based Shotgun Glycomics for Discovery of Natural Ligands of Glycan-Binding Proteins was published in Analytical Chemistry.

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Scientists develop new tools to study the immune system - Folio - University of Alberta

Seeing the Chemistry of Vision – Technology Networks

The biochemistry of vision is a complex process. The molecules supporting the visual pigments that allow us to see our surrounding reality have remained essentially invisible for scientists for a long time. The team led by Prof. Maciej Wojtkowski from the International Centre for Translational Eye Research (ICTER) has changed that, thanks to an innovative state-of-the art imaging device that they have developed.

It is commonly said that eyes are the mirror of the soul; however, they are undoubtedly our window on the world. The retina of the eye represents the first and very important processing station for the path of light as it is converted into an image. Molecular reactions occurring in the retina are crucial for the perception of visual stimuli from the environment.

For many years scientists and doctors have not been able to observe molecules present in the natural milieu of the retinal photosensitive cellsin vivo. The team of scientists led by Prof. Maciej Wojtkowski from ICTER at theInstitute of Physical Chemistry, Polish Academy of Sciences(IPC PAS) have developed a two-photon excited fluorescence scanning laser ophthalmoscope (TPEF-SLO). It is an instrument that remarkably allows viewing the biochemistry of vision in the living eye in real time. Prof. Wojtkowski points out that thanks to close collaborations with biochemist Prof. Kris Palczewski from the University of California Irvine and the laser group of Prof. Grzegorz Sobo from the Wrocaw University of Science and Technology, we can quickly and effectively demonstrate the capabilities of the new imaging method and validate its utility for diagnosing disease progression and treatment, leading to its use in clinical practice.

The human eye is one of the most precise organs of our body, capable of distinguishing about 200 pure colors. Mixing these colors produces about 17,000 different hues, and taking into account our ability to distinguish about 300 intensities of color associated with light intensity, we get a staggering 5 million perceived colors.

The retina, the part of the eye that receives visual stimuli, contains photosensitive cells, cones and rods. The cones enable us to see and distinguish colors in bright light, while the rods are sensitive to single pulses of visible light at dusk or night. Visual impressions are transmittedviathe optic nerve to the primary visual cortex in the brain, but the signals that carry the visual impressions are the result of biochemical processes that occur in the photoreceptors. Simplifying, we can say that the human eye is a biochemical factory whose activity depends on biochemical transformations of a single molecule, retinal. This molecule is indispensable for the function of the visual pigments, namely rhodopsin in rods says Prof. Maciej Wojtkowski.

Rhodopsin, the visual pigment in rods is a light sensitive G-protein coupled receptor (GPCR). Absorption of a quantum of radiation causes isomerization of 11-cis-retinal within the rhodopsin binding pocket and subsequent hyperpolarization of the photoreceptor membranes. In this manner the visual impulse is initiated and transmitted to the brain. A deficiency of vitamin A, precursor of retinal, reduces the ability to see at night, known as night blindness or nyctalopia.

Unfortunately, the molecules indispensable for sustaining visual pigments are undetectable by scientific instruments during virtually the entire visual cycle in living humans. However, there is one instant in the visual cycle when the molecules can be seen; we cant detect them with UV light, but we can observe them thanks to so-called fluorescence with two-photon excitation, adds Dr. Jakub Boguslawski, a main researcher on the project.

Ophthalmic imaging techniques are fundamental in diagnosing retinal pathologies. With optical tomography (OCT), scanning laser ophthalmoscopy (SLO), and fundus autofluorescence, we have made advances in understanding mechanisms of eye diseases. This collection of advanced technologies, however, is an insufficient arsenal for full insight into the chemistry of vision. Non-invasive assessment of metabolic processes occurring in retinal cells (visual pigment regeneration) is essential for the development of future therapies. In the case of age-related macular degeneration (AMD), which is one of the most common diseases causing blindness, cells within a disease-altered retina cannot be distinguished at an early stage from cells of a normal healthy retina. However, the differences can be picked up by biochemical markers, if these markers can be fluorescently induced.

This is the idea behind two-photon fluorescence imaging (TPE). It is an advanced technique for measuring compounds that support the function of visual pigments and are not visible in other tests.

Compared to traditional imaging methods based on single-photon fluorescence, TPE allows the metabolites of vitamin A that are involved in vision, such as retinol or retinol esters, to be viewed. The eye is an ideal organ for multiphoton imaging, says Prof. Wojtkowski, whose team is responsible for the discovery. Eye tissues such as the sclera, cornea, and lens are highly transparent to near-infrared light. This, in turn, penetrates retinal tissues in a non-invasive way.

Images obtained with TPEF-SLO have confirmed that this is an effective way to view the molecules that sustain visual function. Comparison of data from humans with retinal degeneration with mouse models of the disease revealed a similar rapid accumulationof bisretinoid condensation products. We believe that visual cycle intermediates and toxic byproducts of this metabolic pathway could be measured and quantified using TPE imaging, says Dr. Grazyna Palczewska, one of the projects main investigators.

This new age instrument, enabling non-invasive assessment of the metabolic state of the human retina, opens numerous therapeutic possibilities for degenerative diseases of the retina, including the testing of new drugs. By understanding the biochemistry of vision and the alterations that occur in disease, physicians will be able to pinpoint precise locations of the lesions and assess the impact of therapy. The research on TPEF-SLO was published inThe Journal of Clinical Investigation.

Reference:Boguslawski J, Palczewska G, Tomczewski S, et al. In vivo imaging of the human eye using a two-photon excited fluorescence scanning laser ophthalmoscope. J Clin Invest. 2021. doi:10.1172/JCI154218

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

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Seeing the Chemistry of Vision - Technology Networks

Servoss and Thallapuranam to Jointly Serve as Co-Directors of Undergraduate Research – University of Arkansas Newswire

University Relations

Shannon Servoss, associate professor of chemical engineering, and Suresh Thallapuranam, professor of biochemistry, will serve as co-directors of undergraduate research.

During the summer months, theOffice of Research and Innovation conducted an internal search to fill the position of an undergraduate research director. Out of the candidate pool, two UofA professors impressed the panel with their career experience and passion for working with undergraduate students. Shannon Servoss, associate professor of chemical engineering, and Suresh Thallapuranam, professor of biochemistry, were offered appointments as co-directors of undergraduate research and both agreed to share the title and responsibilities thereof.

The duties of this position entail supporting undergraduate research and creative activities across academic disciplines. The two professors will report to Wesley Stites, associate vice chancellor for research and innovation. They will coordinate withHonors College and the Office of Research and Innovation to fulfill their mission. Tasks vary from year to year. For the 2020-2021 academic school year, duties will include relaunching the undergraduate research journal, Inquiry, engaging in conversations with colleges and departments to encourage research activity among non-Honors students, and gathering regular feedback from undergraduate participants and faculty mentors about how to maintain and improve programs.

We are thrilled to have Professors Servoss and Thallapuranam to take the leadership role for UAs Undergraduate Research Office, Vice Chancellor Daniel Sui said. As research increasingly becomes an integral part of the experiential learning experience for undergraduates worldwide, I am confident Professors Servoss and Thallapuranam will work with the rest of the faculty on campus to bring UAs undergraduate research to a new level of excellence in the coming years.

Servoss and Thallapuranam will also oversee the implementation of improvements in student programs and routinely assess their effectiveness. They will also frequently communicate with theOffice for Student Success and offices of undergraduate research at peer institutions. Another item in their interest is to develop zero credit hour courses related to research methods and ethics for students not enrolled in the Honors College. The co-directors will also work with research administration staff in the tracking and tracing of funding and expenditures which support research activities at the undergraduate level.

With theI3R Initiative on the horizon, there is an enormous opportunity for expanding undergraduate research at the UofA. The new co-directors of undergraduate research are excited to continue sparking innovation and encouraging collaboration among the student body.

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Servoss and Thallapuranam to Jointly Serve as Co-Directors of Undergraduate Research - University of Arkansas Newswire

Growth of Electrolyte and Biochemistry Analyzers in Global IndustryOverview, Size and Share 2020-2025 – PRnews Leader

TheElectrolyte and Biochemistry AnalyzersMarket carries out financial changes that occur year by years in market, with information about upcoming opportunities and risk to keeps you ahead of competitors. The report also describes top company profiles that present in market with trends worldwide. This research guided you for extending business.

The Electrolyte and Biochemistry Analyzers Market research report presents a comprehensive assessment of the market and contains thoughtful insights, facts, historical data and statistically-supported and industry-validated market data and projections with a suitable set of assumptions and methodology. It provides analysis and information by categories such as market segments, regions, and product type and distribution channels.

Request a sample of this premium research:@https://www.bigmarketresearch.com/request-sample/3958662

Top Key Players Present in Global Electrolyte and Biochemistry AnalyzersMarket Are:, Roche, Danaher, Siemens, Abbott, Hitachi, Horiba Medical, Mindray, ThermoFisher, Shanghai Kehua Bio-Engineering Co., Ltd, Senlo, Sunostik, ELITec Group, Sysmex, Jiangxi TECom, URIT Medical Electronic, Randox Laboratories, Dirui, Shenzhen Rayto, Convergent Technologies, Meizhou Cornley, Diestro, Caretium, Erba Mannheim, Hycel Medical, Idexx Laboratories, Nova Biomedical, SFRI, Medica, Shenzhen Genius Biotech Inc, Sensa Core,

A proper understanding of the Electrolyte and Biochemistry Analyzers Market dynamics and their inter-relations helps in gauging the performance of the industry. The growth and revenue patterns can be revised and new strategic decisions taken by companies to avoid obstacles and roadblocks. It could also help in changing the patterns using which the market will generate revenues. The analysis includes an assessment of the production chain, supply chain, end user preferences, associated industries, proper availability of resources, and other indexes to help boost revenues.

Based on Detailed Regional Analysis, the regional segmentation has been carried out for regions of U.S., Canada, Germany, France, U.K., Italy, Russia, China, Japan, South Korea, Taiwan, Southeast Asia, Mexico, and Brazil, etc. Key regions covered in the report are North America, Europe, Asia-Pacific and Latin America.

Global Electrolyte and Biochemistry Analyzers market is presented to the readers as a holistic snapshot of the competitive landscape within the given forecast period. It presents a comparative detailed analysis of the all regional and player segments, offering readers a better knowledge of where areas in which they can place their existing resources and gauging the priority of a particular region in order to boost their standing in the global market.

The Global Electrolyte and Biochemistry Analyzers Market is gaining pace and businesses have started understanding the benefits of analytics in the present day highly dynamic business environment. The market has witnessed several important developments over the past few years, with mounting volumes of business data and the shift from traditional data analysis platforms to self-service business analytics being some of the most prominent ones.

For the future period, sound forecasts on market value and volume are offered for each type and application. In the same period, the report also provides a detailed analysis of market value and consumption for each region. These insights are helpful in devising strategies for the future and take necessary steps. New project investment feasibility analysis and SWOT analysis are offered along with insights on industry barriers. Research findings and conclusions are

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Table of Content:

1. Electrolyte and Biochemistry AnalyzersMarket Overview

2. Market Competition by Manufacturers

3. Production and Capacity by Region

4. Global Electrolyte and Biochemistry Analyzers Consumption by Regions

5. Electrolyte and Biochemistry Analyzers Production, Revenue, Price Trend by Type

6. Global Electrolyte and Biochemistry Analyzers Market Analysis by Application

7. Company Profiles and Key Figures in Electrolyte and Biochemistry Analyzers Business

8. Electrolyte and Biochemistry AnalyzersManufacturing Cost Analysis

9. Marketing Channel, Distributors and Customers

10. Market Dynamics

11. Production and Supply Forecast

12. Consumption and Demand Forecast

13. Forecast by Type and by Application (2020-2026)

14. Research Finding and Conclusion

15. Methodology and Data Source

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Growth of Electrolyte and Biochemistry Analyzers in Global IndustryOverview, Size and Share 2020-2025 - PRnews Leader

Differences in the Clinical and Hematological Characteristics of COVID-19 Patients with and without Type 2 Diabetes – DocWire News

This article was originally published here

J Diabetes Res. 2020 Dec 2;2020:1038585. doi: 10.1155/2020/1038585. eCollection 2020.

ABSTRACT

OBJECTIVE: To examine whether comorbidity with type 2 diabetes (T2D) affects the clinical and hematological parameters of coronavirus disease 2019 (COVID-19) patients.

METHODS: We retrospectively investigated the clinical, imaging, and laboratory characteristics of patients with confirmed COVID-19 who were hospitalized from January 30, 2020 to March 17, 2020, at the Renmin Hospital of Wuhan University. A detailed clinical record was kept for each subject, including the medical history of COVID-19 and physical and laboratory examinations. A total of 164 subjects were eligible for the study, among which 40 patients were comorbid with T2D. Further analysis was conducted in two subcohorts of sex- and age-matched patients with and without T2D to identify hematological and biochemical differences. The laboratory tests, including routine blood tests, serum biochemistry, and coagulation function, were performed upon admission.

RESULTS: The two groups showed no significant differences in baseline parameters, including age, sex, chest X-ray, or computed tomography (CT) findings, upon admission. However, patients with T2D showed an increased incidence of diarrhea. T2D patients required more recovery time from pneumonia, as shown by follow-up CT findings, which might contribute to the prolonged hospitalization. Comorbidity with T2D also increased risk of secondary bacterial infection during COVID-19. The T2D group had significantly higher white blood cell and neutrophil counts compared with the nondiabetic group, but T2D patients suffered from more severe lymphocytopenia and inflammation (P < 0.05). Most biochemical parameters showed no significant differences between the two groups (P > 0.05). However, patients with T2D seemed to have a significantly higher risk of developing hyperlactatemia, hyponatremia, and hypocalcemia.

CONCLUSIONS: COVID-19 patients comorbid with T2D demonstrated distinguishing clinical features and hematological parameters during the infection. It is necessary to develop a different clinical severity scoring system for COVID-19 patients with T2D. This study may provide helpful clues for the assessment and management of COVID-19 in T2D patients.

PMID:33376750 | PMC:PMC7745050 | DOI:10.1155/2020/1038585

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Differences in the Clinical and Hematological Characteristics of COVID-19 Patients with and without Type 2 Diabetes - DocWire News

Two seniors and an alumnus are selected as Churchill Scholars – Yale News

Two Yale seniors Megan He and Sarah Zhao and alumnus James Diao 18 are among the 18 recipients of prestigious Churchill Scholarships for the 2022-23 academic year.

The scholarships support one year of masters study at Churchill College in the University of Cambridge, funding full tuition, a competitive stipend, travel costs, and the chance to apply for a $4,000 research grant.

Yale is the first institution to have three Churchill Scholars in a single cohort.

Sarah Zhao is one of 16 students to be selected for a Churchill Scholarship in science, math, and engineering. Megan He and James Diao are the only two individuals who were named Kanders Churchill Scholars in science policy.

Established in 1963, the scholarship program was established at the request of Sir Winston Churchill as part of the founding of Churchill College, Cambridge, a predominantly science and technology college named in his honor. It seeks to deepen the U.S.-U.K. partnership in order to advance science and technology on both sides of the Atlantic to ensure future prosperity and security.

The Kanders Churchill Scholarships, created in 2017, are awarded to applicants for Cambridge Universitys masters program in public policy. Each college or university is limited to only two nominations for the Churchill Scholarships in science, math, and engineering.

Megan He 22

Megan He is majoring in environmental engineering and global affairs at Yale, where she will also receive a certificate in energy studies. Her undergraduate research in the laboratory of Drew Gentner, associate professor of chemical and environmental engineering, focuses on emissions of organic compounds to the atmosphere and their impact on air quality. She has also conducted research on atmospheric deposition at the cole Polytechnique Fdrale de Lausanne in Switzerland. In 2021, she was awarded a Goldwater Scholarship.

At Yale, she is chair of the environmental engineering departmental club, an engineering tour guide and STEM representative in the Office of Undergraduate Admissions, and a peer tutor in the physics department. She is also active with the Goldwater Community Executive Council and the Evolutions After School Program at the Yale Peabody Museum. At Cambridge, she will delve into science policy as it relates to air pollution, climate, and energy. After Cambridge, she plans to pursue a Ph.D. in environmental engineering.

Sarah Zhao 22

Sarah Zhao is pursuing a joint B.S./M.A. in statistics and data science at Yale, along with a double major in mathematics. Her main research interests are in the theory and development of novel data science methods for complex, real-world data, and she has worked on research in quantum information and computing, statistics theory, optimization, and geometrical and topological data science methods. She also won a 2021 Goldwater Scholarship and is a member of Phi Beta Kappa.

Outside of research, she volunteers for the Yale Education Tutoring Initiative and dances in Yale Movement. At Cambridge, she will pursue a M.Phil. degree in advanced computer science with a focus on machine learning.

James Diao 18

James Diao graduated magna cum laude from Yale, majoring in statistics and data science and molecular biophysics and biochemistry. He is now a third-year medical student at Harvard Medical School and the Massachusetts Institute of Technology. At Yale, he developed extracellular RNA analysis tools in the laboratory of Mark Gerstein, the Albert L. Williams Professor of Biomedical Informatics at Yale School of Medicine, and he performed with the Yale Ballroom Dance Team. He was also a peer counselor for the undergraduate-run Walden Peer Counseling. Diaos research has been published in the New England Journal of Medicine and JAMA, profiled in Nature and Science, and cited in national recommendations for kidney care.

He is a 2021 Paul and Daisy Soros Fellow and was named to the 2022 Forbes 30 Under 30 list in the category of healthcare. As a Kanders Churchill Scholar, he will pursue a masters degree in public policy at Cambridge University.

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Two seniors and an alumnus are selected as Churchill Scholars - Yale News

Biochemical Incubator Market Projected to be Resilient During 2020 2026 – Zenit News

The global Covid-19 Impact on Biochemical Incubator Market gives detailed Evaluation about all of the Important aspects related to the market. The study on international Covid-19 Impact on Biochemical Incubator economy, offers deep insights regarding the Covid-19 Impact on Biochemical Incubator market covering all of the crucial aspects of the marketplace.

Moreover, the report provides historical information with prospective forecast over the forecast period. Various important factors like market trends, revenue growth patterns market stocks and supply and demand are contained in almost all the market research document for every business. A number of the important aspects analyzed in the report contains market share, creation, key regions, revenue rate as well as key players.

Key Companies/Manufacturers operating in the global Biochemical Incubator Market market include: WIGGENS, IRM, Binder, ZHETU, EDESON, Brocent, YSEI, ThermoFisher Scientific, HUITAI, Memmert, LABOTERY, TATUNG, LEAD Tech, HITACHI, SANTN, Labnet.

Our analysis involves the study of the market taking into consideration the impact of the COVID-19 pandemic. Please get in touch with us to get your hands on an exhaustive coverage of the impact of the current situation on the market. Our expert team of analysts will provide as per report customized to your requirement.

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Global Biochemical Incubator Market: Segmentation

Global Biochemical Incubator Market Segmentation: By Types

70L150L250L350L500L

Global Biochemical Incubator Market segmentation: By Applications

Environmental ProtectionHealth And Epidemic PreventionDrug Testing

Global Biochemical Incubator Market Segmentation: By Region

1) North America (United States, Canada)2) Europe (Germany, France, UK, Italy, Russia, Spain, Netherlands, Switzerland, Belgium)3) Asia Pacific (China, Japan, Korea, India, Australia, Indonesia, Thailand, Philippines, Vietnam)4) Middle East & Africa (Turkey, Saudi Arabia, United Arab Emirates, South Africa, Israel, Egypt, Nigeria)5) Latin America (Brazil, Mexico, Argentina, Colombia, Chile, Peru)

This report provides:

Reasons to Buy This Report:

To summarize,the global Biochemical Incubator market report studies the contemporary market to forecast the growth prospects, challenges, opportunities, risks, threats, and the trends observed in the market that can either propel or curtail the growth rate of the industry. The market factors impacting the global sector also include provincial trade policies, international trade disputes, entry barriers, and other regulatory restrictions.

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Table of content :

Section 1 Industry Overview

Section 2 Global Biochemical Incubator Competition by Types, Applications, and Top Regions and Countries

Section 3 Production Market Analysis

Section 4 Global Biochemical Incubator Sales, Consumption, Export, Import by Regions (2015-2020)

Section 5 North America Biochemical Incubator Market Analysis

Section 6 East Asia Biochemical Incubator Market Analysis

Section 7 Europe Biochemical Incubator Market Analysis

Section 8 South Asia Biochemical Incubator Market Analysis

Section 9 Southeast Asia Biochemical Incubator Market Analysis

Section 10 Middle East Biochemical Incubator Market Analysis

Section 11 Africa Biochemical Incubator Market Analysis

Section 12 Oceania Biochemical Incubator Market Analysis

Section 13 South America Biochemical Incubator Market Analysis

Section 14 Company Profiles and Key Figures in Biochemical Incubator Business

Section 15 Global Biochemical Incubator Market Forecast (2021-2026)

Section 16 Conclusions

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Biochemical Incubator Market Projected to be Resilient During 2020 2026 - Zenit News

The Story of Wall Shear Stress in Coronary Artery Atherosclerosis: Biochemical Transport and Mechanotransduction – DocWire News

This article was originally published here

J Biomech Eng. 2020 Nov 6. doi: 10.1115/1.4049026. Online ahead of print.

ABSTRACT

Coronary artery atherosclerosis is a local, multifactorial, complex disease, and the leading cause of death in the US. Complex interactions between biochemical transport and biomechanical forces influence disease growth. Wall shear stress (WSS) affects coronary artery atherosclerosis by inducing endothelial cell mechanotransduction and by controlling the near-wall transport processes involved in atherosclerosis. Each of these processes is controlled by WSS differently and therefore has complicated the interpretation of WSS in atherosclerosis. In this paper, we present a comprehensive theory for WSS in atherosclerosis. First, a short review of shear stress-mediated mechanotransduction in atherosclerosis was presented. Next, subject-specific computational fluid dynamics (CFD) simulations were performed in ten coronary artery models of diseased and healthy subjects. Biochemical-specific mass transport models were developed to study low-density lipoprotein, nitric oxide, adenosine triphosphate, oxygen, monocyte chemoattractant protein-1, and monocyte transport. The transport results were compared with WSS vectors and WSS Lagrangian coherent structures (WSS LCS). High WSS magnitude protected against atherosclerosis by increasing the production or flux of atheroprotective biochemicals and decreasing the near-wall localization of atherogenic biochemicals. Low WSS magnitude promoted atherosclerosis by increasing atherogenic biochemical localization. Finally, the attracting WSS LCSs role was more complex where it promoted or prevented atherosclerosis based on different biochemicals. We present a summary of the different pathways by which WSS influences coronary artery atherosclerosis and compare different mechanotransduction and biotransport mechanisms.

PMID:33156343 | DOI:10.1115/1.4049026

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The Story of Wall Shear Stress in Coronary Artery Atherosclerosis: Biochemical Transport and Mechanotransduction - DocWire News

Feasibility and early toxicity of focal or partial brachytherapy in prostate cancer patients – DocWire News

This article was originally published here

J Contemp Brachytherapy. 2020 Oct;12(5):420-426. doi: 10.5114/jcb.2020.100374. Epub 2020 Oct 30.

ABSTRACT

PURPOSE: The aim of this study was to compare short-term oncologic outcomes and toxicity of focal or partial low-dose-rate brachytherapy (focal/partial LDR-BT) with whole gland low-dose-rate brachytherapy (whole LDR-BT) in localized prostate cancer patients.

MATERIAL AND METHODS: Medical records of eligible patients who underwent focal/partial LDR-BT and whole LDR-BT between 2015 and 2017 at our institution were reviewed retrospectively. Clinical characteristics and pathologic outcomes were compared between focal/partial LDR-BT group and whole LDR-BT group. Biochemical recurrence-free survival was analyzed using Kaplan-Meier method and difference between two groups was assessed with log-rank test. Genitourinary and rectal toxicity were also evaluated between the two groups.

RESULTS: Of the 60 patients analyzed, 30 focal/partial LDR-BT patients and 30 whole LDR-BT brachytherapy patients were included. Relative to the whole LDR-BT group, the focal/partial LDR-BT group had significantly higher initial PSA level (p = 0.002), smaller number of implanted seeds (p < 0.001), and shorter follow-up duration (p < 0.001). There was no significant difference between the two groups with regard to prostate volume, biopsy Gleason score, and risk group stratification. The 3-year biochemical recurrence-free survival estimates for focal/partial LDR-BT group and whole LDR-BT group were 91.8% and 89.6%, respectively, which was not significantly different (p = 0.554). Genitourinary symptoms were significantly worse in whole LDR-BT group than in focal/partial LDR-BT group. The incidence of rectal toxicity was similar between two groups.

CONCLUSIONS: Our findings indicate that the focal/partial LDR-BT is comparable to the whole LDR-BT with respect to short-term biochemical recurrence and toxicities.

PMID:33299430 | PMC:PMC7701917 | DOI:10.5114/jcb.2020.100374

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Feasibility and early toxicity of focal or partial brachytherapy in prostate cancer patients - DocWire News