Genetic Engineering OSCSS Bio Commercial – Video

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Genetic Engineering OSCSS Bio Commercial
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Selectively manipulating protein modifications

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Public release date: 10-Mar-2013 [ | E-mail | Share ]

Contact: Michael Hottiger hottiger@vetbio.uzh.ch 41-446-355-474 University of Zurich

This press release is available in German.

Protein activity is strictly regulated. Incorrect or poor protein regulation can lead to uncontrolled growth and thus cancer or chronic inflammation. Members of the Institute of Veterinary Biochemistry and Molecular Biology from the University of Zurich have identified enzymes that can regulate the activity of medically important proteins. Their discovery enables these proteins to be manipulated very selectively, opening up new treatment methods for inflammations and cancer.

For a healthy organism, it is crucial for proteins to be active or inactive at the right time. The corresponding regulation is often based on a chemical modification of the protein structure: Enzymes attach small molecules to particular sites on a protein or remove them, thereby activating or deactivating the protein. Members of the Institute of Veterinary Biochemistry and Molecular Biology from the University of Zurich in collaboration with other Institutes have now discovered how the inactivation of a protein, which is important for medicine, can be reversed.

New group of ADP-ribosylhydrolases identified

An important protein modification is ADP-ribosylation, which is involved in certain types of breast cancer, cellular stress reactions and gene regulation. So-called ADP-ribosyltransferases attach the ADP ribose molecule to proteins, thereby altering their function. In recent years, many ADP-ribosyltransferases have been discovered that can convey single or several ADP-riboses to different proteins. Enzymes that can remove these riboses again, however, are less well known. Professor Michael Hottiger's team of researchers has now identified a new group of such ADP-ribosylhydrolases. The scientists discovered that a so-called macrodomain is responsible for removing the ADP-riboses in human proteins, but also in the bacterium Archaeoglobus fulgidus.

"We therefore assume that the reversal of the modification takes place in a similar way in different species," explains Michael Hottiger.

Biomedically relevant: inactivation of the modified enzyme GSK3

The researchers also prove that ADP-ribosylhydrolases can remove the ADP-ribose of the intensively studied enzyme GSK3, which regulates the synthesis of storage substances and is important in the progression of various diseases. ADP-ribosylation deactivates GSK3, which can be reversed again by the newly identified enzyme. "Our discovery enables ADP-ribose modification to be manipulated and tested selectively, and new treatment methods developed for diseases such as inflammations or cancer," concludes Michael Hottiger.

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Selectively manipulating protein modifications

Behavioral Science week 1 assignment – Video

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Behavioral Science week 1 assignment
Behavioral Science week 1 assignment. marvin raines3 videos. Subscribe Subscribed Unsubscribe 0. 5 views. Like 0 Dislike 0. Like ... Full Sail UniversityBehavioral Science Jumping Hurdles Projectby iceproducer 643 views; 431. Watch Later Week 1 Introduction VideoShannon WelchMPGby mollie aschenbrener 148 views; 13457. Watch Later Science and the taboo of psi with Dean Radinby googletechtalks 161132 views; 12249. Watch Later 2 Reincarnation in Human Evolution The New Science of ...

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Incest Party: Taiwan Hardware Show – Shanghai World Travel Fair 2013 | The Oxford Murders – Video

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Incest Party: Taiwan Hardware Show - Shanghai World Travel Fair 2013 | The Oxford Murders
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Incest Party: Taiwan Hardware Show - Shanghai World Travel Fair 2013 | The Oxford Murders - Video

Fox World Travel Announces Group Travel to Vietnam and Cambodia along the Mekong River

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Fox World Travel recently announced an escorted group vacation exploring Vietnam and Cambodia along the Mekong River March 1-17, 2014. This combination land and river cruise vacation will be escorted by Rose Gray, host of the Fox World Travel Show on 620 WTMJ and the package will include airfare from Chicago O'Hare, a 15 day land and river cruise adventure with Uniworld Boutique River Cruises, food, beverages, hotel stays and so much more!

Milwaukee, Wisconsin (PRWEB) March 11, 2013

Hosted by Rose Gray, the travel agents at Fox World Travel are confident you will be in great company.

"Having had the good fortune to work in the travel industry for almost 30 years, I have had the opportunity to visit many of my must see destinations. Vietnam and Cambodia have been at the top of my list for many years; two completely different worlds joined by one life-giving river, the Mekong," said Rose.

Rose is a child of the sixtys and seventys, so of course both countries unique histories and ties to the United States are intriguing to her. More than that, she wants to visit these magnificent countries whose traditional charm and exceptional beauty are just beginning to open up to the outside world. In March of 2014, this travel wish is going to come true as Rose Gray and others discover Vietnam and Cambodia.

Uniworld offers an intimate encounter inside Vietnam and Cambodia. Be part of small groups as you descend into villages, markets and cultural sites, with one local guide for every twenty guests. Meet the people and visit the places that make up these fascinating destinations. In addition, travel to floating villages and sites by way of a luxurious sampan, and encounter a genuine experience every step of the way.

Uniworlds commitment to intimacy extends to the shipboard experience as well. The River Orchid, boasts just 30 deluxe staterooms, and no more than 60 guests at a time. This means that guests will be treated to gracious and personalized service. The staff onboard the River Orchid will be there to ensure guests have everything they needmorning, noon, and night. Whether sitting on the spacious sun deck being served a refreshing complimentary beverage as you watch the passing scenery or listening to an enlightening lecture, the staff will stand ready to make stays as special and comfortable as can be. Theres simply no better way to experience the magic of these destinations along the Mekong River.

Highlights Include: Hanaoi, Vietnam; Siem Reap, Cambodia; Kampong Cham, Cambodia; Wat Hanchey,Kampong Cham, Cambodia; Angkor Ban, Chong Koh, Cambodia; Kampong Chhnang, Cambodia; Phnom Penh, Cambodia; Chau Doc, Vietnam; Sa Dec, Vietnam; My Tho, Vietnam; Ho Chi Minh City, Vietnam.

For details on this exciting escorted river cruise exploring Vietnam, Cambodia and the Mekong River, visit http://www.gofox.com/vietnam or contact a Vietnam Travel Specialist at Fox World Travel by calling 877-794-2551.

Travel Specialist Fox World Travel (888) 369-8785 Email Information

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Fox World Travel Announces Group Travel to Vietnam and Cambodia along the Mekong River

UFO Sighting At International Space Station On March 8, 2013, NASA Live Cam Footage. – Video

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UFO Sighting At International Space Station On March 8, 2013, NASA Live Cam Footage.
I was looking at the live nasa cam that shows the ISS and got lucky and caught a UFO in the distance that was matching speed with the space station. This UFO...

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UFO Sighting At International Space Station On March 8, 2013, NASA Live Cam Footage. - Video

Astronaut Scott Kelly Selected for One-Year Mission Aboard International Space Station – Video

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Astronaut Scott Kelly Selected for One-Year Mission Aboard International Space Station
TWO PICKED FOR YEAR-LONG STAY ON ISS -- JSC Astronaut Scott Kelly has been selected by NASA to begin a one-year mission aboard the International Space Statio...

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Space station to get special telescope

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Published: March. 11, 2013 at 8:32 PM

CHICAGO, March 11 (UPI) -- NASA says it's giving $4.4 million to five U.S. universities to help the agency build a telescope for deployment on the International Space Station in 2017.

University scientists along with researchers at NASA's Marshall Space Flight Center in Alabama will join an international project to build an 8-foot ultraviolet telescope, the Extreme Universe Space Observatory, to search for the mysterious source of the most energetic particles in the universe from the space station's Japanese Experiment Module.

The origin of these energetic particles, called ultra high-energy cosmic rays, has remained a mystery since they were discovered more than 50 years ago, researchers said.

"The science goal is to discover the sources of ultra high-energy cosmic rays by observing their traces in the atmosphere looking 248 miles from the ISS down to the surface," said astronomy and astrophysics Professor Angela Olinto of the University of Chicago, one of the participating institutions.

Olinto said the believes the Extreme Observatory could be the first step toward using the entire Earth atmosphere for studying subatomic particle interactions at energies far exceeding what the most powerful man-made particle accelerators on Earth can currently produce.

"In my opinion it's the way to the future," said Olinto, who leads the U.S. collaboration on the project.

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Space station to get special telescope