NASA strives to tame 'big data' flowing in from dozens of missions

PASADENA, Calif., Oct. 18 (UPI) -- NASA says new strategies will be needed to manage the ever-increasing flow of large and complex data streams from the agency's many space missions.

Dozens of missions pour in data every day like rushing rivers -- data that need to be stored, indexed and processed so spacecraft engineers, scientists and people across the globe can use the data to understand Earth and the universe beyond, the agency said.

For NASA missions, hundreds of terabytes -- one terabyte is equivalent to the information printed on 50,000 trees worth of paper -- are gathered every hour, creating what the technology community dubs "big data."

"Scientists use big data for everything from predicting weather on Earth to monitoring ice caps on Mars to searching for distant galaxies," Eric De Jong of NASA's Jet Propulsion Laboratory in Pasadena, Calif., said.

De Jong is the principal investigator for NASA's Solar System Visualization project, which converts NASA mission science into visualization products that researchers can use.

"We are the keepers of the data, and the users are the astronomers and scientists who need images, mosaics, maps and movies to find patterns and verify theories," he said.

Scientists face three challenges in dealing with the huge amounts of data from space missions, he said -- storage, processing and access.

Rather than build more hardware for storage, engineers are developing creative software tools to better store the information, such as "cloud computing" techniques and automated programs for extracting data.

For processing, JPL has been increasingly turning to open-source software, creating improved data processing tools for space missions.

"We don't need to reinvent the wheel," said Chris Mattmann, a principal investigator for JPL's big-data initiative. "We can modify open-source computer codes to create faster, cheaper solutions."

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NASA strives to tame 'big data' flowing in from dozens of missions

Nanotechnology World Wide Town Hall – "Energy, Climate, and Innovation" – Video


Nanotechnology World Wide Town Hall - "Energy, Climate, and Innovation"
The Nanotechnology Town Hall Meeting series is designed to explore the many ways in which nanotechnology might impact our world. This Town Hall features a la...

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Foundation Medicine Announces Publication of Analytic Validation Study of FoundationOneâ„¢ in Nature Biotechnology

CAMBRIDGE, Mass.--(BUSINESS WIRE)--

Foundation Medicine, Inc. (FMI) today announced that results from a 24-month, multi-institution collaboration demonstrating the analytic validation of its cancer genomic profiling assay, FoundationOne, were published in the current online edition of Nature Biotechnology.1 FoundationOne is a comprehensive, next-generation sequencing (NGS) based test used to characterize all classes of molecular alterations (base substitutions, short insertions and deletions (indels), copy number alterations and select rearrangements) across 287 cancer-related genes from routine formalin-fixed, paraffin-embedded (FFPE) clinical specimens. The publication also describes clinical application of this assay across 2,221 consecutive patient cases.

Comprehensive genomic testing is becoming critical to deliver the most effective care for patients with cancer. However, analytic validation of NGS-based tests presents a challenge to clinical application due to the fact that thousands of potential variants may be detected, and most have no gold standard with which to compare. This publication is the first to apply and extend the guidelines established by the Next-Generation Sequencing: Standardization of Clinical Testing (Nex-StoCT) workgroup2 to validate a clinical sequencing-based assay for cancer, therefore setting the standard for validation of targeted NGS in cancer.

Clinical cancer care is undergoing a fundamental shift toward treating patients based on the specific molecular drivers of their disease, and a sequencing-based diagnostic assay that comprehensively and accurately characterizes the genomic alterations occurring within an individuals tumor is essential for the implementation of this therapeutic strategy, stated Lajos Pusztai, M.D., co-director of the Cancer Genetics and Genomics Research Program at Yale Cancer Center and co-author of the study. This study is instrumental in establishing the technical validity of next-generation sequencing in the clinic and enables the practice of precision medicine wherein the molecular characterization of a patients tumor informs the patients individual treatment.

Foundation Medicine assessed the accuracy and precision of FoundationOne using reference samples of pooled cell lines and hundreds of clinical cancer specimens with diagnostic testing results generated by established clinical assays. FoundationOne was found to be highly accurate in identifying genomic alterations, including sensitivity greater than 99% for detection of base substitutions, 98% for detection of insertions and deletions, and greater than 95% for detection of copy number alterations, while maintaining greater than 99% specificity. Application of FoundationOne to 2,221 clinical cases revealed clinically actionable alterations in 76% of tumor samples, three times the number of actionable alterations detected by other currently available diagnostic tests. Alterations are defined as clinically actionable if linked to an FDA approved targeted therapy in the tumor under study or another solid tumor, a known or suspected contraindication to a given therapy, or an open clinical trial for which the alteration confers patient eligibility.

FoundationOne was proven to have the sensitivity and specificity required for routine clinical practice, and it identified more than three times the clinically actionable alterations that are identifiable using a collection of six commercially available and commonly used diagnostic tests, including the other most common NGS-based tests. This comprehensive approach directly translates into more treatment options for patients, said Michael J. Pellini, M.D., president and chief executive officer of Foundation Medicine. We believe this study establishes the standard for analytic performance that is required for patients with cancer to benefit from the clinical application of next-generation sequencing of their tumors.

About Foundation Medicine

Foundation Medicine (FMI) is a molecular information company dedicated to a transformation in cancer care in which treatment is informed by a deep understanding of the genomic changes that contribute to each patients unique cancer. The companys initial clinical assay, FoundationOneTM, is a fully informative genomic profile to identify a patients individual molecular alterations and match them with relevant targeted therapies and clinical trials. Foundation Medicines molecular information platform aims to improve day-to-day care for patients by serving the needs of clinicians, academic researchers and drug developers to help advance the science of molecular medicine in cancer. For more information, please visit http://www.FoundationMedicine.com or follow Foundation Medicine on Twitter (@FoundationATCG).

Foundation Medicine is a registered trademark, and FoundationOneTMis a trademark of Foundation Medicine, Inc.

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Foundation Medicine Announces Publication of Analytic Validation Study of FoundationOneâ„¢ in Nature Biotechnology

Make over your medicine cabinet with natural cures

Whether youre suffering from a headache or fighting off a cold, odds are the first place you turn for help is your medicine cabinet. But are over-the-counter medications always the safest option?

Dr. Beverly Yates, a naturopathic physician, recently sat down with Dr. Manny Alvarez, senior managing health editor of FoxNews.com to share her tips on how to replace the conventional cures in your medicine cabinet with natural remedies this cold and flu season.

Colds and coughs: Yates said that one of the problems with over-the-counter (OTC) medications for things like colds and coughs is that once you stop taking them, you can get rebound symptoms that may become worse. But using natural remedies like Similasan Cold & Flu Mucus Relief can help activate the immune system to fight off illness.

Those chemicals suppress, they drive the symptoms deeper, said Yates. You're stimulating your body to heal, so your natural processes and your immune system do their jobs more effectively, without forcing it to kind of hide.

Many OTC cold products are also not recommended for children younger than 4 years old. But using something like Similasan Kids Cold & Mucus Relief can help to temporarily relieve symptoms of the common cold such as sneezing, runny nose, head and chest congestion. Zinc lozenges can also help bolster the immune system, but Yates noted that they can cause some nausea if taken on an empty stomach.

Nausea/upset stomach: Studies have shown that ginger contains very potent anti-inflammatory compounds called gingerols that can help relieve motion sickness, dizziness, nausea and gas, and soothe the intestinal tract.

One of the best and most effective choices you can take are products that contain ginger, or to actually eat some ginger root, said Yates. Even if someone's on something as powerful as chemotherapy, or if they're just a little under the weather; maybe they have a tummy bug, they're nauseated perhaps because they're a little nervous ginger is very effective, and it's easy to take it as a supplement.

Diarrhea/constipation: Laxatives and anti-diarrheal medications carry the risk of various side effects, and Yates said they should only be used under a doctors care.

If you're constipated, you can use products that contain Sunfiber, said Yates. It's water soluble, has no unpleasant taste or anything, and it dissolves clear, so it's very easy to use -- unlike some fiber products that can be problematic it won't aggravate, let's say things like ulcerative colitis or Crohn's.

Yates said that probiotics like Kyo-Dophilus can also be used to help with some stomach ailments. It contains beneficial bacteria that support intestinal health, immune function and digestion.

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Make over your medicine cabinet with natural cures

UB’s medical school is just the latest highlight as new energy continues to remake city

The day that ground was broken for the University at Buffalos new downtown medical school was a day that few people thought would come. That, alone, makes it a remarkable event. Even more remarkable, though, is that it is only the latest in a series of days that few people thought would ever come. Gov. Andrew M. Cuomo said it well: This is a new Buffalo.

The work is going on around the city, but no project is more exciting or holds more potential than the medical schools move downtown, where it will join and leverage the development of the Buffalo Niagara Medical Campus. The economic potential of the campus is huge. The schools move there will help attract top students and professors.

The project is a $375 million endeavor, helping to achieve the goal of bringing hospitals, research and doctor-training facilities to one downtown location. There is plenty else there already. Buffalo General Medical Center and Roswell Park Cancer Institute are two longtime residents of the neighborhood. Add to that the Gates Vascular Institute, UBs Clinical and Translational Research Center and the Hauptmann-Woodward Institute.

And there will be more. Soon, the John R. Oishei Childrens Hospital will move there from Elmwood Avenue. Also pending are Ciminelli Real Estate Corp.s medical office building and Roswell Parks Clinical Sciences Center. And only a few blocks to the south, Catholic Health is building a new headquarters.

It is a startling development in a neighborhood whose economic engine was little but two neighboring hospitals. The activity there will surely attract other development, as entrepreneurs seek to serve the thousands of people who will be living and working in that area.

What is more, the developments in and around the Medical Campus are not alone. Several such developments are under way around Buffalo sites that Cuomo toured on Tuesday when he came here for the medical schools groundbreaking.

Most obvious is the waterfront, where the Erie Canal Harbor Development Corp. is leading a breathtaking reimagining of the citys most underused asset. At the inner harbor, Canalside is springing to life as a center of public activities, including concerts.

It is already leveraging other development, as the former Donovan State Office Building is transformed into a law office and hotel. Across the street, in the Webster Block, Buffalo Sabres owner Terry Pegula is constructing a huge building that will house a hotel and two full-size hockey rinks, expected to leverage further economic activity by attracting tournaments to Buffalo.

Soon, with the sale of outer harbor land by the Niagara Frontier Transportation Association, a park and other developments will begin to take shape there. The redevelopment of Ohio Street into an attractive parkway will ease access to the new parkland.

To the east, Larkinville is one of the citys great surprises. Led by Buffalos most public-spirited developer, Howard Zemsky, the revival of a dormant district began with the renovation of the Larkin Building. As its offices filled, activity spread to nearby buildings and spilled out onto the street, where concerts, food trucks and other public attractions are reinjecting vitality into what had been one of Buffalos forgotten neighborhoods.

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UB’s medical school is just the latest highlight as new energy continues to remake city

Assassin’s Creed 4: Black Flag Soundtrack – The Islands of the West Indies – Video


Assassin #39;s Creed 4: Black Flag Soundtrack - The Islands of the West Indies
Assassin #39;s Creed 4: Black Flag OST - The Islands of the West Indies Composed by Brian Tyler. Playlist: http://www.youtube.com/playlist?list=PLO_WZCimKasyFnho...

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Assassin's Creed 4: Black Flag Soundtrack - The Islands of the West Indies - Video

Kiwis romp past Cook Islands in warm-up

New Zealand warmed up for their defence of the World Cup with a 50-0 rout of the Cook Islands in Doncaster.

Winger Jason Nightingale started and finished the scoring and centre Bryson Goodwin also scored two tries of the nine tries as the Kiwis comfortably avoided the fate that befell England and France.

Both of those nations suffered shock defeats at the hands of World Cup minnows in their warm-up matches over the weekend.

New Zealand were without five members of Sydney Roosters' NRL Grand Final-winning team but standoff Kieran Foran, from beaten finalists Manly, was drafted into the side.

Foran replaced Wigan favourite Thomas Leuluai, who rested a hamstring injury.

Hooker Issac Luke was a constant threat at dummy-half and created one of the tries of the match, after taking a quick penalty tap, scampering 40 metres, and throwing a long ball for Nightingale to score.

Coach Stephen Kearney says the hitout will benefit his players ahead of their World Cup title defence, which begins against Samoa in Warrington on Sunday.

"There were parts of our game that were a bit rusty out there, but it was a good start for us," he said.

"The improvement areas are in both defence and attack, to be fair, and given that some of the guys haven't played in six weeks it was a good performance, but our focus for this week is to improve both areas."

The Kiwis never looked back after running in three tries in the first 16 minutes through Nightingale, winger Manu Vatuvei and loose forward Elijah Taylor but they had to wait until eight minutes before halftime for their next score, when Goodwin touched down Foran's delicate kick for his first try.

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Kiwis romp past Cook Islands in warm-up

Kiwis too strong for Cook Islands

The Kiwis have plenty to work on, but theyll be pleased to have kept the Cook Islands to nil today in their Rugby League World Cup warm-up match in Doncaster. After leading 24-0 at half-time, the Kiwis ran out 50-0 winners.

Among the standouts for New Zealand were Issac Luke, Sam Kasiano and Bryson Goodwin, who scored two tries in his first game for the Kiwis since 2009. One of Goodwins efforts, involving beautiful in-and-away footwork, saw him score directly from a scrum.

"The guys are certainly better for a run," said the Kiwis coach Stephen Kearney. "There were parts of our game that were a bit rusty out there, but it was a good start for us.

"The improvement areas are in both defence and attack, to be fair, and given that some of the guys havent played in six weeks it was a good performance, but our focus for this week is to improve both areas."

Kieran Foran, the Kiwis vice-captain, was brought into the team as a late replacement for Thomas Leuluai, who rested a groin strain. Foran was due to sit this match out, along with other Kiwi players who were involved in the NRL grand final, but instead combined in the halves with Shaun Johnson for just the second time, following Aprils test against the Kangaroos in Canberra. Johnsons pace was on show as he scored from 60m in the second half.

The Kiwis bench for this game - which wasnt an official test match - was extended before kick-off with the inclusion of Roger Tuivasa-Sheck. He got to wear the Kiwis jersey for the first time, playing 10mins at the end.

Man of the Match awards were announced for each team and went to Tinirau Arona for the Cook Islands and Issac Luke for the Kiwis. Luke was a constant threat at dummy-half and created one of the tries of the match, after taking a quick penalty tap, scampering 40metres, and throwing a long ball for Jason Nightingale to score in the right hand corner.

The game, played in front of 4,638, was the first match since the NRL regular season for many of the Kiwis, including their captain Simon Mannering.

Before the match, the Kiwis delivered a new haka, led by Issac Luke. Called Te Iwi Kiwi, the haka was created by members of the Kiwi team along with a cultural advisor.

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Kiwis too strong for Cook Islands