A.I. Artificial Intelligence – Wikipedia, the free encyclopedia

A.I. Artificial Intelligence, also known as A.I., is a 2001 American science fiction drama film written, directed, and produced by Steven Spielberg, and based on Brian Aldiss's short story "Super-Toys Last All Summer Long". The film stars Haley Joel Osment, Jude Law, Frances O'Connor, Brendan Gleeson, and William Hurt. Set sometime in the future, A.I. tells the story of David, a childlike android uniquely programmed with the ability to love.

Development of A.I. originally began with director Stanley Kubrick in the early 1970s. Kubrick hired a series of writers up until the mid-1990s, including Brian Aldiss, Bob Shaw, Ian Watson, and Sara Maitland. The film languished in development hell for years, partly because Kubrick felt computer-generated imagery was not advanced enough to create the David character, whom he believed no child actor would believably portray. In 1995, Kubrick handed A.I. to Spielberg, but the film did not gain momentum until Kubrick's death in 1999. Spielberg remained close to Watson's film treatment for the screenplay. The film was greeted with generally favorable reviews from critics and grossed approximately $235 million. A small credit appears after the end credits, which reads "For Stanley Kubrick."

In the late 21st century, global warming has flooded coastlines, and a drastic reduction of the human population has occurred. There is a new class of robots called Mecha, advanced humanoids capable of emulating thoughts and emotions. David (Osment), a prototype model created by Cybertronics of New Jersey, is designed to resemble a human child and to display love for its human owners. They test their creation with one of their employees, Henry Swinton (Robards), and his wife Monica (O'Connor). The Swintons' son, Martin (Thomas), was placed in suspended animation until a cure can be found for his rare disease, caused by the Sinclair virus. Although Monica is initially frightened of David, she eventually warms to him and activates his imprinting protocol, which irreversibly causes David to project love for her, the same as any child would love a parent. He is also befriended by Teddy (Angel), a robotic teddy bear, who takes it upon himself to care for David's well-being.

A cure is found for Martin and he is brought home; a sibling rivalry ensues between Martin and David. Martin convinces David to go to Monica in the middle of the night and cut off a lock of her hair, to get him in trouble, but the parents wake up and are very upset. At a pool party, one of Martin's friends activates David's self-protection programming by poking him with a knife. David clings to Martin and they both fall into the pool, where the heavy David sinks to the bottom while still clinging to Martin. Martin is saved from drowning, but Henry in particular is shocked by David's actions, becoming concerned that David's capacity for love has also given him the ability to hate. Henry persuades Monica to return David to Cybertronics, where David will be destroyed. However, Monica cannot bring herself to do this, and instead abandons David in the forest (with Teddy) to hide as an unregistered Mecha. David is captured for an anti-Mecha Flesh Fair, an event where obsolete and unlicensed Mecha are destroyed in front of cheering crowds. David is nearly killed, but the crowd is swayed by his realistic nature and he escapes, along with Gigolo Joe (Law), a male prostitute Mecha on the run after being framed for murder.

The two set out to find the Blue Fairy, whom David remembers from the story The Adventures of Pinocchio. He is convinced that the Blue Fairy will transform him into a human boy, allowing Monica to love him and take him home. Joe and David make their way to Rouge City. Information from a holographic answer engine called "Dr. Know" (Williams) eventually leads them to the top of Rockefeller Center in partially flooded Manhattan. David meets his human creator, Professor Allen Hobby (Hurt), who excitedly tells David that finding him was a test, which has demonstrated the reality of his love and desire. It also becomes clear that many copies of David are already being manufactured, along with female versions. David sadly realizes he is not unique. A disheartened David attempts to commit suicide by falling from a ledge into the ocean, but Joe rescues him with the amphibicopter. David tells Joe he saw the Blue Fairy underwater, and wants to go down to her. At that moment, Joe is captured by the authorities with the use of an electromagnet, but sets the amphibicopter on submerge. David and Teddy take it to the fairy, which turns out to be a statue from a submerged attraction at Coney Island. Teddy and David become trapped when the Wonder Wheel falls on their vehicle. Believing the Blue Fairy to be real, David asks to be turned into a real boy, repeating his wish without end, until the ocean freezes in another ice age and his internal power source drains away.

Two thousand years later humans are extinct and Manhattan is buried under several hundred feet of glacial ice. Mecha have evolved into a silicon-based, highly advanced and intelligent, alien-looking futuristic Mecha, with the ability to perform some form of time manipulation and telekinesis. On their project to studying humans believing it was the key to understanding the meaning of existence they find David and Teddy and discover they are original Mecha who knew living humans, making them special and unique. David is revived and walks to the frozen Blue Fairy statue, which cracks and collapses as he touches it. Having received and comprehended his memories, the advanced Mecha use them to reconstruct the Swinton home and explain to David via an interactive image of the Blue Fairy (Streep) that it is impossible to make him human. However, at David's insistence, they recreate Monica from DNA in the lock of her hair which Teddy had saved for unknown reasons. One of the futuristic Mecha tells David that the clone can only live for a single day, and the process cannot be repeated. But David keeps insisting, so they fast forward the time to the next morning, and David spends the happiest day of his life with Monica and Teddy. Monica tells David that she loves him, and has always loved him, as she drifts to sleep for the last time. David lies down next to her, closes his eyes and goes "to that place where dreams are born". Teddy enters the room, climbs onto the bed, and watches as David and Monica lie peacefully together.

Kubrick began development on an adaptation of "Super-Toys Last All Summer Long" in the early 1970s, hiring the short story's author, Brian Aldiss to write a film treatment. In 1985, Kubrick brought longtime friend Steven Spielberg on board to produce the film,[3] along with Jan Harlan. Warner Bros. agreed to co-finance A.I. and cover distribution duties.[4] The film labored in development hell, and Aldiss was fired by Kubrick over creative differences in 1989.[5]Bob Shaw served as writer very briefly, leaving after six weeks because of Kubrick's demanding work schedule, and Ian Watson was hired as the new writer in March 1990. Aldiss later remarked, "Not only did the bastard fire me, he hired my enemy [Watson] instead." Kubrick handed Watson The Adventures of Pinocchio for inspiration, calling A.I. "a picaresque robot version of Pinocchio".[4][6]

Three weeks later Watson gave Kubrick his first story treatment, and concluded his work on A.I. in May 1991 with another treatment, at 90 pages. Gigolo Joe was originally conceived as a GI Mecha, but Watson suggested changing him to a male prostitute. Kubrick joked, "I guess we lost the kiddie market."[4] In the meantime, Kubrick dropped A.I. to work on a film adaptation of Wartime Lies, feeling computer animation was not advanced enough to create the David character. However, after the release of Spielberg's Jurassic Park (with its innovative use of computer-generated imagery), it was announced in November 1993 that production would begin in 1994.[7]Dennis Muren and Ned Gorman, who worked on Jurassic Park, became visual effects supervisors,[5] but Kubrick was displeased with their previsualization, and with the expense of hiring Industrial Light & Magic.[8]

Stanley [Kubrick] showed Steven [Spielberg] 650 drawings which he had, and the script and the story, everything. Stanley said, "Look, why don't you direct it and I'll produce it." Steven was almost in shock.

In early 1994, the film was in pre-production with Christopher "Fangorn" Baker as concept artist, and Sara Maitland assisting on the story, which gave it "a feminist fairy-tale focus".[4] Maitland said that Kubrick never referred to the film as A.I., but as Pinocchio.[8]Chris Cunningham became the new visual effects supervisor. Some of his unproduced work for A.I. can be seen on the DVD, The Work of Director Chris Cunningham.[10] Aside from considering computer animation, Kubrick also had Joseph Mazzello do a screen test for the lead role.[8] Cunningham helped assemble a series of "little robot-type humans" for the David character. "We tried to construct a little boy with a movable rubber face to see whether we could make it look appealing," producer Jan Harlan reflected. "But it was a total failure, it looked awful." Hans Moravec was brought in as a technical consultant.[8]

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A.I. Artificial Intelligence - Wikipedia, the free encyclopedia

What Does Artificial Intelligence Really Mean, Anyway?

The great promise--and great fear--of Artificial Intelligence has always been that some day, computers would be able to mimic the way our brains work. However, after years of progress, AI isnt just a long way from HAL 9000, it has gone in an entirely different direction. Some of the biggest tech companies in the world are beginning to implement AI in some form, and it looks nothing like we thought it would.

In a piece for the BBCs website, writer Tom Chatfield examines the recent AI initiatives from companies like Facebook--which announced last week that it would be partnering with NYU to build an artificial intelligence team that hopes to develop a computer that will develop insights from enormous data sets--and argued that such developments are completely contrary to the classic definition of AI as a field.

Chatfields argument is centered on a feature in the Atlantic on cognitive scientist Douglas Hofstadter, who believes that what Facebook is doing, along with other recent advances like IBMs Watson, doesnt qualify as "intelligence." Writes Chatfield:

For Hoftstadter, the label intelligence is simply inappropriate for describing insights drawn by brute computing power from massive data sets because, from his perspective, the fact that results appear smart is irrelevant if the process underlying them bears no resemblance to intelligent thought. As he put it to interviewer James Somers, I dont want to be involved in passing off some fancy programs behaviour for intelligence when I know that it has nothing to do with intelligence. And I dont know why more people arent that way.

To that end, Chatfield argues that weve created something entirely different. Instead of machines that think like humans, we now have machines that think in an entirely different, perhaps even alien, way. Continuing to shoehorn them into replicating our natural thought processes could be limiting.

Some are inclined to agree. Writing for the MIT Technology Review, Tom Simonite reiterates just how bad computers are at tasks that are easy for brains, like image recognition. Simonite attributes this to the way weve been building computer chips. Namely, that its going to be impossible for computers to imitate non-linear thought processes if we continue to use hardware thats designed to execute linear sequences of instructions--the CPU-RAM design called the Von Neumann architecture. Instead, an answer may lie with neuromorphic chips like IBMs Synapse, which are specifically designed to work the way our brains do.

The problem, Simonite writes, will be making them work on a larger scale. It is still unclear whether scaling up these chips will produce machines with more sophisticated brainlike faculties. And some critics doubt it will ever be possible for engineers to copy biology closely enough to capture these abilities.

As it turns out, copying biology is really damn hard. While scientists like Hofstadter prop up the platonic ideal of AI as a computer that functions the same way our brains do, perhaps the Deep Learning approach embraced by Google is the means by which we get there. Maybe you dont need neuromorphic chips to build a real-life HAL. Maybe you just need lots and lots of data.

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Miller: Artificial intelligence: Our final invention?

Even when our debates seem petty, you cant say national politics doesnt deal with weighty matters, from jobs to inequality to affordable health care and more. But lately Ive become obsessed with an issue so daunting it makes even the biggest normal questions of public life seem tiny. Im talking about the risks posed by runaway artificial intelligence (AI). What happens when we share the planet with self-aware, self-improving machines that evolve beyond our ability to control or understand? Are we creating machines that are destined to destroy us?

I know when I put it this way it sounds like science fiction, or the ravings of a crank. So let me explain how I came to put this on your screen.

Matt Miller

A senior fellow at the Center for American Progress and the host of the new podcast This...Is Interesting, Miller writes a weekly column for The Post.

Archive

A few years ago I read chunks of Ray Kurzweils book The Singularity Is Near. Kurzweil argued that what sets our age apart from all previous ones is the accelerating pace of technological advance an acceleration made possible by the digitization of everything. Because of this unprecedented pace of change, he said, were just a few decades away from basically meshing with computers and transcending human biology (think Google, only much better, inside your head). This development will supercharge notions of intelligence, Kurzweil predicted, and even make it possible to upload digitized versions of our brains to the cloud so that some form of us lives forever.

Mind-blowing and unsettling stuff, to say the least. If Kurzweils right, I recall thinking, what should I tell my daughter about how to live or even about what it means to be human?

Kurzweil has since become enshrined as Americas uber-optimist on these trends. He and other evangelists say accelerating technology will soon equip us to solve our greatest energy, education, health and climate challenges en route to extending the human lifespan indefinitely.

But a camp of worrywarts has sprung up as well. The skeptics fear that a toxic mix of artificial intelligence, robotics and bio- and nanotechnology could make previous threats of nuclear devastation seem easy to manage by comparison. These people arent cranks. Theyre folks like Jaan Tallinn, the 41-year-old Estonian programming whiz who helped create Skype and now fears hes more likely to die from some AI advance run amok than from cancer or heart disease. Or Lord Martin Rees, a dean of Britains science establishment whose last book bore the upbeat title, Our Final Century and who with Tallinn has launched the Center for the Study of Existential Risk at Cambridge to think through how bad things could get and what to do about it.

Now comes James Barrat with a new book Our Final Invention: Artificial Intelligence and the End of the Human Era that accessibly chronicles these risks and how a number of top AI researchers and observers see them. If you read just one book that makes you confront scary high-tech realities that well soon have no choice but to address, make it this one.

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Artifical intelligence inspires movie

Spike Jonze was inspired by how efficiently 'artificial intelligence' could simulate conversation with a human in his new film 'Her'.

The 44-year-old director's forthcoming movie is about a modern day romance in which depressed writer Theodore Twombly - played by Joaquin Phoenix - falls in love with his new computer and smartphone operating system named Samantha, voiced by Scarlett Johansson.

Jonze began thinking about a virtual romance after reading a piece on online communication between a digital device and a person and 'got a buzz' when the intelligence could 'keep up' with him.

He said: 'The very tiniest seed came about 10 years ago when I saw this article online that said you can interact live with an artificial intelligence. So I went to the website, and I IM-ed this address, and I was like, 'Hi, how are you?' and I got responses like, 'Great, how are you?' And you can talk to it and tease it - not a him or her, it's just typing - and get a little banter going, getting mocked and so on. I got this sort of buzz thinking: this thing's actually keeping up with me.'

Jonze began noticing flaws in the digital responses after a while of talking but, on the whole, he was still astounded by the 'clever' device.

He explained: 'After a couple of minutes you start to notice the cracks and the flaws. 'Oh, this is a very cleverly written program', I thought in the end.

'But for those couple of minutes I got a very distinctive, tingly kind of buzz from the experience. The movie has a lot of large conceptual ideas holding it up, but most of all, I always wanted to make it a moving relationship movie - that was what I was most interested in.'

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Facebook hires French artificial intelligence guru

Professor Yann LeCun, who is currently lecturing at NYUs Center for Data Science, has been studying AIfor decades.

While for now Facebook feeds may seem like a random jumble, LeCun argues these can be improved by intelligent systems.

This could include things like ranking (the items in) news feeds, or determining the ads that are shown to users, to be more relevant, he told AFP.

Then there are things that are less directly connected, like analyzing content, understanding natural language and being able to model users to allow them to learn new things, entertain them and help them achieve their goals.

Limited by the number of smart people in the world

Facebook is the worlds biggest social network; but like all web services, it faces the challenge of maintaining growth, keeping users engaged and delivering enough advertising to generate revenue without annoying its users.

LeCun said the new artificial intelligence lab would be the largest research facility of its kind in the world, though he declined to provide numbers.

Were limited only by how many smart people there are in the world that we can hire, the Paris-born mathematician and computer scientist said.

The lab will be based in three locations New York, London and at Facebooks California headquarters.

But it will also be part of the broader artificial intelligence research community, according to LeCun, who starts his new job in January while keeping his NYU post.

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DARPA Tried to Build Skynet in the 1980s

S

From 1983 to 1993 DARPA spent over $1 billion on a program called the Strategic Computing Initiative. The agency's goal was to push the boundaries of computers, artificial intelligence, and robotics to build something that, in hindsight, looks strikingly similar to the dystopian future of the Terminator movies. They wanted to build Skynet.

Much like Ronald Reagan's Star Wars program, the idea behind Strategic Computing proved too futuristic for its time. But with the stunning advancements we're witnessing today in military AI and autonomous robots, it's worth revisiting this nearly forgotten program, and asking ourselves if we're ready for a world of hyperconnected killing machines. And perhaps a more futile question: Even if we wanted to stop it, is it too late?

S

If the new generation technology evolves as we now expect, there will be unique new opportunities for military applications of computing. For example, instead of fielding simple guided missiles or remotely piloted vehicles, we might launch completely autonomous land, sea, and air vehicles capable of complex, far-ranging reconnaissance and attack missions. The possibilities are quite startling, and suggest that new generation computing could fundamentally change the nature of future conflicts.

That's from a little-known document presented to Congress in October of 1983 outlining the mission of the new Strategic Computing Initiative (SCI). And like nearly everything DARPA has done before and since, it's unapologetically ambitious.

The vision for SCI was wrapped up in a completely new system spearheaded by Robert Kahn, then director of Information Processing Techniques Office (IPTO) at DARPA. As it's explained in the 2002 book Strategic Computing, Kahn wasn't the first to imagine such a system, but "he was the first to articulate a vision of what SC might be. He launched the project and shaped its early years. SC went on to have a life of its own, run by other people, but it never lost the imprint of Kahn."

The system was supposed to create a world where autonomous vehicles not only provide intelligence on any enemy worldwide, but could strike with deadly precision from land, sea, and air. It was to be a global network that connected every aspect of the U.S. military's technological capabilitiescapabilities that depended on new, impossibly fast computers.

But the network wasn't supposed to process information in a cold, matter-of-fact way. No, this new system was supposed to see, hear, act, and react. Most importantly, it was supposed to understand, all without human prompting.

S

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Doom 3: BFG Edition – Lost Mission – Level 05: Exis Labs: Union Aerospace Research Division 1 – Video


Doom 3: BFG Edition - Lost Mission - Level 05: Exis Labs: Union Aerospace Research Division 1
My playthrough of Level 05 (Exis Labs: Union Aerospace Research Division 1) of the Lost Mission campaign of Doom 3: BFG Edition for the PC, played on the Vet...

By: Zdenda1990

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Aerospace engineering – Wikipedia, the free encyclopedia

Aerospace engineering is the primary branch of engineering concerned with the research, design, development, construction, testing, science and technology of aircraft and spacecraft.[1] It is divided into two major and overlapping branches: aeronautical engineering and astronautical engineering. The aeronautics deals with aircraft that operate in Earth's atmosphere, and the astronautics deals with spacecrafts that operate outside the Earth's atmosphere.

Aerospace engineering deals with the design, construction, and study of the science behind the forces and physical properties of aircraft, rockets, flying craft, and spacecraft. The field also covers their aerodynamic characteristics and behaviors, airfoil, control surfaces, lift, drag, and other properties.

Aeronautical engineering was the original term for the field. As flight technology advanced to include craft operating in outer space, the broader term "aerospace engineering" has largely replaced it in common usage.[2] Aerospace engineering, particularly the astronautics branch, is often referred to colloquially as "rocket science",[3] such as in popular culture.

Flight vehicles are subjected to demanding conditions such as those produced by extreme changes in atmospheric pressure and temperature, with structural loads applied upon vehicle components. Consequently, they are usually the products of various technological and engineering disciplines including aerodynamics, propulsion, avionics, materials science, structural analysis and manufacturing. The interaction between these technologies is known as aerospace engineering. Because of the number of disciplines involved, aerospace engineering is carried out by teams of engineers, each having their own specialised area of expertise.[4]

The development and manufacturing of a modern flight vehicle is an extremely complex process and demands careful balance and compromise between abilities, design, available technology and costs. Aerospace engineers design, test, and supervise the manufacture of aircraft, spacecraft, and missiles. Aerospace engineers develop new technologies for use in aviation, defense systems, and space.

The origin of aerospace engineering can be traced back to the aviation pioneers around the late 19th to early 20th centuries, although the work of Sir George Cayley has recently been dated as being from the last decade of the 18th to mid-19th century. One of the most important people in the history of aeronautics,[5] Cayley was a pioneer in aeronautical engineering[6] and is credited as the first person to separate the forces of lift and drag, which are in effect on any flight vehicle.[7] Early knowledge of aeronautical engineering was largely empirical with some concepts and skills imported from other branches of engineering.[8] Scientists understood some key elements of aerospace engineering, like fluid dynamics, in the 18th century. Many years later after the successful flights by the Wright brothers, the 1910s saw the development of aeronautical engineering through the design of World War I military aircraft.

The first definition of aerospace engineering appeared in February 1958.[2] The definition considered the Earth's atmosphere and the outer space as a single realm, thereby encompassing both aircraft (aero) and spacecraft (space) under a newly coined word aerospace. In response to the USSR launching the first satellite, Sputnik into space on October 4, 1957, U.S. aerospace engineers launched the first American satellite on January 31, 1958. The National Aeronautics and Space Administration was founded in 1958 as a response to the Cold War.[9]

Some of the elements of aerospace engineering are:[10][11]

The basis of most of these elements lies in theoretical physics, such as fluid dynamics for aerodynamics or the equations of motion for flight dynamics. There is also a large empirical component. Historically, this empirical component was derived from testing of scale models and prototypes, either in wind tunnels or in the free atmosphere. More recently, advances in computing have enabled the use of computational fluid dynamics to simulate the behavior of fluid, reducing time and expense spent on wind-tunnel testing. Those studying hydrodynamics or Hydroacoustics often obtained degrees in Aerospace Engineering.

Additionally, aerospace engineering addresses the integration of all components that constitute an aerospace vehicle (subsystems including power, aerospace bearings, communications, thermal control, life support, etc.) and its life cycle (design, temperature, pressure, radiation, velocity, lifetime).

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Aerospace – Wikipedia, the free encyclopedia

Aerospace comprises the atmosphere of Earth and surrounding space. Typically, aerospace industries combine aeronautics and astronautics to research, design, manufacture, operate, or maintain vehicles moving through air and through space. Aerospace is a very diverse field, with a multitude of commercial, industrial and military applications.

Aerospace is not the same as airspace, which is the physical air space directly above a location on the ground.

In most industrial countries, the aerospace industry is a cooperation of public and private industries. For example, several countries have a civilian space program funded by the government through tax collection, such as NASA in the United States, ESA in Europe, the Canadian Space Agency in Canada, Indian Space Research Organisation in India, JAXA in Japan, RKA in Russia, China National Space Administration in China, SUPARCO in Pakistan, Iranian Space Agency in Iran, and Korea Aerospace Research Institute (KARI) in South Korea.

Along with these public space programs, many companies produce technical tools and components such as spaceships and satellites. Some known companies involved in space programs include Boeing, EADS, Lockheed Martin, MacDonald Dettwiler and Northrop Grumman. These companies are also involved in other areas of aerospace such as the construction of aircraft.

Modern aerospace began with Sir George Cayley in 1799. Cayley proposed an aircraft with a "fixed wing and a horizontal and vertical tail," defining characteristics of the modern airplane.[1]

The 19th century saw the creation of the Aeronautical Society of Great Britain (1866), the American Rocketry Society, and the Institute of Aeronautical Sciences, all of which made aeronautics a more serious scientific discipline.[1] Airmen like Otto Lilienthal, who introduced cambered airfoils in 1891, used gliders to analyze aerodynamic forces.[1] The Wright brothers were interested in Lilienthal's work and read several of his publications.[1] They also found inspiration in Octave Chanute, an airman and the author of Progress in Flying Machines (1894).[1] It was the preliminary work of Cayley, Lilienthal, Chanute, and other early aerospace engineers that brought about the first powered sustained flight at Kitty Hawk, North Carolina on December 17, 1903, by the Wright brothers.

War and science fiction inspired great minds like Konstantin Tsiolkovsky and Wernher von Braun to achieve flight beyond the atmosphere.

The launch of Sputnik 1 in 1957 started the Space Age, and on July 20, 1969 Apollo 11 achieved the first manned moon landing.[1] In 1981, the Space Shuttle Columbia launched, the start of regular manned access to orbital space. A sustained human presence in orbital space started with "Mir" in 1986 and is continued by the "International Space Station".[1]Space commercialization and space tourism are more recent focuses in aerospace.

Aerospace manufacturing is a high-technology industry that produces "aircraft, guided missiles, space vehicles, aircraft engines, propulsion units, and related parts".[2] Most of the industry is geared toward governmental work. For each original equipment manufacturer (OEM), the US government has assigned a Commercial and Government Entity (CAGE) code. These codes help to identify each manufacturer, repair facilities, and other critical aftermarket vendors in the aerospace industry.

In the United States, the Department of Defense and the National Aeronautics and Space Administration (NASA) are the two largest consumers of aerospace technology and products. Others include the very large airline industry. The aerospace industry employed 472,000 wage and salary workers in 2006.[3] Most of those jobs were in Washington state and in California, with Missouri, New York and Texas also important. The leading aerospace manufacturers in the U.S. are Boeing, United Technologies Corporation, and Lockheed Martin.

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Eclipse Aerospace to add 100 high-paying jobs

The city of Albuquerque would help pay Eclipse Aerospaces rent at the Sunport as the company adds 100 high-paying manufacturing, engineering and administrative jobs over the next two years, under a tentative deal announced this morning.

The city and state would offer up to $635,000. It would come in increments for each 10 new jobs added by Eclipse.

The proposal still must be submitted to the City Council for approval.

The fact that theyre growing in Albuquerque is fantastic, Mayor Richard Berry said this morning as he stood before an Eclipse 550 jet.

Other communities have tried to recruit the company.Gov. Susana Martinez said shes proud Eclipse is staying in New Mexico.

Eclipse CEOMason Holland said the company delivered its first Eclipse 550 jet to a customer yesterday.

Weve turned the corner, he said.

Deirdre Firth, Albuquerques deputy director of economic development, said Eclipse plans to add 100 jobs by the end of 2015. For every 10 jobs added, the company would get help on one months rent, she said.

City and state funds would pay 60 percent of Eclipses rent at the Sunport. The deal would top out at $635,000 if Eclipse reaches its full jobs target.

The citys share of the money comes from its newly created economic-development action fund, which holds money from the clawbacks received when Schott Solar closed down.

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Aerospace Manufacturers Select Ultriva with End to End Pull

Ultriva is continuing expansion with deployment for a new aerospace components company. The Aerospace Industries Association, the premier trade association representing the nation's major aerospace and defense manufacturers, works with 300 major aerospace and defense companies and their suppliers are members of the association, embodying every high-technology manufacturing segment of the U.S. aerospace and defense industry from commercial aviation and avionics, to manned and unmanned defense systems, to space technologies and satellite communications. Ultriva works with many of these leading manufacturers and suppliers and sees great expansion in 2014 likely in areas addressing civil aviation, space, national security, international and procurement and finance.

Known as a pioneer in Kanban solutions, Ultriva CEO Narayan Laksham and the team of technology solutions professionals at the Cupertino-based firm are strongly advocating that aerospace component manufacturers integrate with the demand side to streamline the supply chain. This process is "End to End Pull" replenishment, also known as E2E Pull.

Laksham expanded, "This is clearly a paradigm shift compared to the constant focus on improving the planning or forecasts using better and superior algorithms. The primary goal of the E2E Pull process is to schedule manufacturing production based on customer demand instead of forecasts while raw materials and components usage at the manufacturing facilities should drive replenishment to the upstream supply chain. This is also known as consumption driven replenishment or electronic Kanban loops."

Ultriva is experiencing rapid growth in aerospace with the wide adoption of E2E Pull globally. Underlying the E2E Pull process is real-time collaboration with the customers and suppliers. On-premise solutions, like MRP and ERP, do a great job for inside the four walls of business. E2E Pull is best-suited outside the four walls of business which is why aerospace component manufacturers are adopting the consumption driven replenishment solution. New features in version 7.6 address some of the specific aerospace sector demands. Ultriva has deployed this type of solution across many large multi-national customers worldwide. For more information, visit http://info.ultriva.com/ultriva-version-76.

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Survey: Miami-Dade County residents value public libraries, but would they pay more for them?

Miami-Dade County residents truly love their libraries, but they dont necessarily want to pay more taxes to fund them.

Those are the findings of a new poll conducted on behalf of county government, which is trying to find ways to save the public library system from deep budget cuts. Ninety-five percent of respondents who use the library and 72 percent of non-users said libraries add to their quality of life. Eighty-three percent of respondents disagreed with a statement calling libraries outmoded, obsolete and no longer necessary.

Yet support for increasing the property-tax rate likely the only way to grow the libraries or even keep them intact was inconsistent, according to the survey by Behavioral Science Research, a Coral Gables-based firm.

Forty-four percent of respondents said they would be OK with a tax-rate hike, with 20 percent undecided.

Robert Ladner, the president of Behavioral Science Research, called the support soft.

It is a very vulnerable area, he said this week to Mayor Carlos Gimenezs task force examining the libraries future.

The results mirror a national study published earlier this month by the Pew Internet & American Life Project, which found that 95 percent of Americans 16 and older consider libraries important. Ninety percent said the closure of their local library would have an impact on their community.

But Pew also found that respondents visited libraries less frequently in the past. The study did not ask about library funding.

Nearly half of Miami-Dades libraries, 22 of 49, faced closure this summer when Gimenez and the County Commission kept this years property-tax rate flat. In the end, the politicians spared the libraries and their 169 employees who would have been laid off by raiding one-time reserves.

With those reserves depleted, the county is looking at a shortfall of about $20 million next year to fund the libraries at the same level as this year, unless the tax rate goes up.

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The American Academy of Anti-Aging Medicine (A4M) Concludes Largest Event in Anti-Aging, Regenerative and Aesthetic …

Boca Raton, FL (PRWEB) December 19, 2013

A4Ms largest event, the 21st Annual World Congress on Anti-Aging, Regenerative and Aesthetic Medicine wrapped up on Sunday, December 15th with a record number of attendees and exhibitors present. Over 3,500 attendees, over 300 exhibiting companies and over 50 speakers gathered at the Venetian/Palazzo Resort in Las Vegas, NV December 13th - 15th for a conference on continuing medical education in preventive and integrative medicine.

Among the over 50 speakers were special guests Governor Arnold Schwarzenegger, Suzanne Somers, Dr. Travis Stork, and Dr. Judith Reichman. Gov. Schwarzenegger accepted the 2013 A4M Infinity Award at Saturday afternoons general session for his leadership role in early funding and support of stem cell research and healthcare reform, among other endeavors. Suzanne Somers presentation entitled Our Time Has Come, took place during Friday mornings general session. Travis Stork, MD, emergency room physician and host of Emmy nominated show The Doctors spoke about Your Best Life. Judith Reichman, MD presented Slow Your Clock Down: On- Label, Off- Label, Gray- Label.

Some of the featured presenters included Abraham Morgentaler, MD, FACS who is the Director of Mens Health Boston, Associate Clinical Professor of Urology at Harvard Medical School, Beth Israel Deaconess Medical Center spoke on Testosterone Therapy; Christoph Westphal, MD, PhD who earned his MD from Harvard Medical School and PhD in Genetics from Harvard University presented on Pharmaceutical Approaches to Treating Aging; Erika Schwartz, MD, a leading expert in the field of bio-identical hormone therapies, wellness and disease prevention reviewed the scientific literature on the topic of doctor-patient relationship and attempts to achieve high-quality of care in a clinical setting; some noted International faculty included Massimo Dominici, MD, an assistant professor in Oncology and Hematology at the University of Modena, presenting on Stem Cell Therapy and Eduardo Mansilla, MD who specializes in Internal Medicine in Argentina and has spent more than 15 years working in tissue engineering and regenerative medicine.

In addition to the general conference, over 500 healthcare practitioners attended advanced education Fellowship modules over the course of the weekend. Modules offered in Las Vegas included Modules I, V, XVI, XXII, XXIII, Integrative Cancer Therapy Module VIII and Sexual Health Certification Module D.

Pre- conference, specialty workshops were held on Thursday, December 12th. Workshop topics included Testosterone Deficiency and Therapy in Men, presented by Abraham Morgantaler, MD, FACS; Personalized Lifestyle Medicine, with Pamela W. Smith, MD, MPH, MS; Mark Houston, MD, MS, ABAARM, FACP, FAHA, FASH; Mark Rosenberg, MD; and Tana Amen, BSN, RN; Pellet Therapy, by James Mahoney, MD; and Advances in Body Contouring, with Sharon McQuillan, MD. One additional workshop was offered, as part of the Practice Management Certification. It is a two-part certification course, the first part offered in Las Vegas, the second part will be offered in Orlando in May. To achieve certification in Practice Management, the participant must take the two courses as well as successfully complete an exam after each. On Sunday, December 15th, a post conference, specialty workshop entitled Menopause/Andropause: Improving the Health and Happiness of your Patients with Bio-Identical Hormones, was led by Jonathan Wright, MD and Daved Rosensweet, MD.

Many of the top-in-their field medical presenters who lectured on topics including stem cell therapy, telomeres, mitochondria, brain health, hormone replacement, metabolic syndrome, obesity and more often concluded that the first steps to prepare your patients personal health and longevity is to start living an anti-aging lifestyle; a strategic multi-faceted lifestyle program involving diet, exercise, nutritional therapies and other natural therapies to beneficially prevent and alter the possible series of biological changes that take place in the body as your patient age, stated Amy Paoletti, Marketing Director. This was a prevalent message throughout the three days of lectures..

The exhibit hall, with over 300 booths including 20 sponsors, was home to many conference activities including the New Product Theater which featured a dozen exhibiting companies presenting their latest products via a live demonstration or lecture.

A4Ms 22nd Annual World Congress on Anti-Aging, Regenerative and Aesthetic Medicine will be held at the Gaylord Palms Resort and Convention Center in Orlando, Florida on May 15 17, 2014.

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The American Academy of Anti-Aging Medicine (A4M) Concludes Largest Event in Anti-Aging, Regenerative and Aesthetic ...

What is Anti-Aging Medicine? | Worldhealth.net Anti-Aging News

Anti-aging medicine is the pinnacle of biotechnology joined with advanced clinical preventive medicine. The specialty is founded on the application of advanced scientific and medical technologies for the early detection, prevention, treatment, and reversal of age-related dysfunction, disorders, and diseases. It is a healthcare model promoting innovative science and research to prolong the healthy lifespan in humans. As such, anti-aging medicine is based on principles of sound and responsible medical care that are consistent with those applied in other preventive health specialties. The anti-aging medical model aims to both extend lifespan as well as prolong healthspan the length of time that we are able to live productively and independently.

Anti-aging medicine is the following:

Hundreds of scientific research studies clearly prove that modest interventions in diet, exercise, nutrition and single-gene modulation in the laboratory setting beneficially and significantly impact healthy function in old-age. Many of these interventions also modify maximum lifespan by 20 to 800% as well. With over the near-daily advancements in biomedical technologies related to research specifically focused on elucidating treatments for aging-related disorders and modulating the metabolic dysfunctions associated with old age, in the imminent near-future, effective interventions will become widely available to modulate the aging process itself in humans.

Researchers from the Harvard School of Public Health have found that the anti-aging lifestyle can add 24.6 more years of productive lifespan. The research team found that the longest-living Americans are Asian-American women residing in Bergen County, New Jersey USA. They live longer than any other ethnic group in the United States to an average lifespan of 91.1 years. In contrast, the Harvard team found that the shortest-living Americans are Native American populations in South Dakota, despite receiving free or low-cost government provided medical care living an average lifespan of 66.5 years. A distinguishing characteristic of the Bergen County womens longevity is that they are availing themselves of the armament of state-of-the-art biomedical technologies in advanced preventive care, including preventive screenings, early disease detection, aggressive intervention, and optimal nutrition all of which are cornerstones of the anti-aging medical model. [Bergen County, NJ is long in longevity, New York Times, September 12, 2006; Asian women in Bergen have nations top life expectancy, Free Republic, September 12, 2006.]

A first-ever study reveals the secrets of exceptional health in old age. Mark Kaplan, from Portland State University (Oregon, USA), and colleagues utilized the Health Utilities Index Mark 3 (HUI3), a multidimensional measure of health status, to examine the maintenance of exceptionally good health among 2,432 elder Canadians enrolled in the Canadian National Population Health Survey, which tracked participants health for a ten-year period, 1994 to 2004. The researchers found that the most important predictors of excellent health over the entire decade were:

The team comments that: Many of these factors can be modified when you are young or middle-aged. While these findings may seem like common sense, now we have evidence of which factors contribute to exceptional health [as we age]. [Kaplan MS, Huguet N, Orpana H, Feeny D, McFarland BH, Ross N. Prevalence and factors associated with thriving in older adulthood: a 10-year population-based study. J Gerontol A Biol Sci Med Sci. 2008 Oct;63(10):1097-104.]

Around the world, people are seeking medical guidance for ways to stay healthy, active, and vital well into their older years. As a result, the principles of the anti-aging lifestyle are gaining rapid and widespread acceptance as a framework for lifelong habits for healthy living.

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What is Anti-Aging Medicine? | Worldhealth.net Anti-Aging News

Bedtime for toddlers: Timing is everything

Dec. 16, 2013 The bedtime you select for your toddler may be out of sync with his or her internal body clock, which can contribute to difficulties for youngsters attempting to settle in for the night, according to a new University of Colorado Boulder study.

The study pinpointed the time when the hormone melatonin increased in the evening, indicating the start of the biological night, in a group of 14 toddlers whose sleep also was studied over the course of six days. The study showed that toddlers with later melatonin rise times took longer to fall asleep after being put to bed, said CU-Boulder Assistant Professor Monique LeBourgeois.

"There is relatively little research out there on how the physiology of toddlers may contribute to the emergence of sleep problems," said LeBourgeois, a faculty member in the integrative physiology department who led the new study. "Sleeping at the wrong 'biological clock' time leads to sleep difficulties, like insomnia, in adults."

While adults get to choose their own bedtime, toddlers rarely have this option, said LeBourgeois. "This study is the first to show that a poor fit between bedtimes selected by the parents of toddlers and the rise in their evening melatonin production increases their likelihood of nighttime settling difficulties," said LeBourgeois.

The findings are important because about 25 percent of toddlers and preschoolers have problems settling after bedtime, said LeBourgeois. Evening sleep disturbance can include difficulties falling asleep, bedtime resistance, tantrums, and episodes known as "curtain calls" that manifest themselves as calling out from bed or coming out of the bedroom, often repeatedly, for another story, glass of water or bathroom trip, she said.

Toddlers with longer intervals between the onset of nightly melatonin release and their subsequent bedtimes were shown to fall asleep more quickly and had decreased bedtime resistance as reported by their parents, according to the study.

A paper on the subject was published this month in the journal Mind, Brain and Education. Co-authors included University Children's Hospital Zurich Director of Child Development Oskar Jenni and CU-Boulder Associate Professor Kenneth Wright Jr. The National Institute of Mental Health funded the study.

Sleep problems in early childhood are predictive of later emotional and behavioral problems, as well as poor cognitive function, that can persist into later childhood and adolescence. In addition, parents of young children with sleep problems often report increased difficulties in their own sleep patterns, which can cause chronic fatigue and even marital discord, she said.

"A natural next step is to optimize our knowledge of the interactions between physiology and the environment to further understand how problems like bedtime resistance first develop and how they are maintained," LeBourgeois said.

Research in adolescents and adults has shown that exposure to light in the evening can delay the timing onset of melatonin. Whether the later rise of melatonin in some toddlers can be pushed to an earlier time by restricting evening light or by increasing morning light exposure is a question still to be answered, she said.

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Bedtime for toddlers: Timing is everything

Social science – Wikipedia, the free encyclopedia

This article is about the science studying social groups. For the integrated field of study intended to promote civic competence, see Social studies.

Social science refers to the academic disciplines concerned with society and the relationships among individuals within a society, which often rely primarily on empirical approaches. It is commonly used as an umbrella term to refer to anthropology, economics, political science, psychology and sociology. In a wider sense, it may often include some fields in the humanities[1] such as archaeology, area studies, communication studies, cultural studies, folkloristics, history, law, linguistics, and rhetoric. The term may however be used in the specific context of referring to the original science of society, established in 19th century, sociology (Latin: socius, "companion"; Greek , lgos, "word", "knowledge", "study."). mile Durkheim, Karl Marx and Max Weber are typically cited as the principal architects of modern social science by this definition.[2]

Positivist social scientists use methods resembling those of the natural sciences as tools for understanding society, and so define science in its stricter modern sense. Interpretivist social scientists, by contrast, may use social critique or symbolic interpretation rather than constructing empirically falsifiable theories, and thus treat science in its broader sense. In modern academic practice, researchers are often eclectic, using multiple methodologies (for instance, by combining the quantitative and qualitative techniques). The term social research has also acquired a degree of autonomy as practitioners from various disciplines share in its aims and methods.[citation needed]

The history of the social sciences begins in the Age of Enlightenment after 1650, which saw a revolution within natural philosophy, changing the basic framework by which individuals understood what was "scientific". Social sciences came forth from the moral philosophy of the time and was influenced by the Age of Revolutions, such as the Industrial Revolution and the French Revolution.[3] The social sciences developed from the sciences (experimental and applied), or the systematic knowledge-bases or prescriptive practices, relating to the social improvement of a group of interacting entities.[4][5]

The beginnings of the social sciences in the 18th century are reflected in the grand encyclopedia of Diderot, with articles from Rousseau and other pioneers. The growth of the social sciences is also reflected in other specialized encyclopedias. The modern period saw "social science" first used as a distinct conceptual field.[6] Social science was influenced by positivism,[3] focusing on knowledge based on actual positive sense experience and avoiding the negative; metaphysical speculation was avoided. Auguste Comte used the term "science sociale" to describe the field, taken from the ideas of Charles Fourier; Comte also referred to the field as social physics.[3][7]

Following this period, there were five paths of development that sprang forth in the social sciences, influenced by Comte on other fields.[3] One route that was taken was the rise of social research. Large statistical surveys were undertaken in various parts of the United States and Europe. Another route undertaken was initiated by mile Durkheim, studying "social facts", and Vilfredo Pareto, opening metatheoretical ideas and individual theories. A third means developed, arising from the methodological dichotomy present, in which social phenomena were identified with and understood; this was championed by figures such as Max Weber. The fourth route taken, based in economics, was developed and furthered economic knowledge as a hard science. The last path was the correlation of knowledge and social values; the antipositivism and verstehen sociology of Max Weber firmly demanded this distinction. In this route, theory (description) and prescription were non-overlapping formal discussions of a subject.

Around the start of the 20th century, Enlightenment philosophy was challenged in various quarters. After the use of classical theories since the end of the scientific revolution, various fields substituted mathematics studies for experimental studies and examining equations to build a theoretical structure. The development of social science subfields became very quantitative in methodology. The interdisciplinary and cross-disciplinary nature of scientific inquiry into human behavior, social and environmental factors affecting it, made many of the natural sciences interested in some aspects of social science methodology.[8] Examples of boundary blurring include emerging disciplines like social research of medicine, sociobiology, neuropsychology, bioeconomics and the history and sociology of science. Increasingly, quantitative research and qualitative methods are being integrated in the study of human action and its implications and consequences. In the first half of the 20th century, statistics became a free-standing discipline of applied mathematics. Statistical methods were used confidently.

In the contemporary period, Karl Popper and Talcott Parsons influenced the furtherance of the social sciences.[3] Researchers continue to search for a unified consensus on what methodology might have the power and refinement to connect a proposed "grand theory" with the various midrange theories which, with considerable success, continue to provide usable frameworks for massive, growing data banks; for more, see consilience. The social sciences will for the foreseeable future be composed of different zones in the research of, and sometime distinct in approach toward, the field.[3]

The term "social science" may refer either to the specific sciences of society established by thinkers such as Comte, Durkheim, Marx, and Weber, or more generally to all disciplines outside of "noble science" and arts. By the late 19th century, the academic social sciences were constituted of five fields: jurisprudence and amendment of the law, education, health, economy and trade, and art.[4]

Around the start of the 21st century, the expanding domain of economics in the social sciences has been described as economic imperialism.[9]

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Social science - Wikipedia, the free encyclopedia

US NSF – Funding – National Science Foundation

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York College December 2013 graduates

York College of Pennsylvania December 2013 graduates for York and Adams counties are:

Jeffrey Capezio, Hellam Township, general studies; April Conway, Dover, criminal justice; Megan Croft, Red Lion, general studies; Kyanna Daugherty, Dover, general studies; Jordan Mitzel, York, business administration and Chad Riley, New Oxford, criminal justice.

Brittany Alfone, York, criminal justice; Nicholas Altland, York, nursing with highest honors; Dylan Anglada, Lower Chanceford Township, criminal justice; Sandra Arnold, York, marketing; Judith Ayers, Fawn Township, mass communications and political science; Karen Bailey, Hanover, respiratory care; Cassandra Beaumont, Dallastown, nursing; Ryan Bechtel, York, respiratory care; Kristen Bennett, Hanover, nursing; Jennifer Beste, Shrewsbury, early elementary education with honors; Justin Billet, York, mathematics; Jennifer Bixler, York Haven, nursing; Christopher Bloschichak, Hanover, criminal justice; McKenzie Bowman, Hellam Township, nursing with highest honors; Sarah Bradley, Dover, accounting; Thomas Brigman, Wrightsville, biology; Zachary Brown, York, English literary studies; Chad Brown, Manchester, criminal justice; Deborah Burger, East Berlin, nursing; Angelina Burkhardt, Mount Wolf, criminal justice; Suzanne Burt, York, history; Caanen Churukha, New Oxford, philosophy; Michael Crumling, Windsor, fine art; Brittany D'Onofrio, York, behavioral science; Amanda Damron, Hanover, business administration; Benjamin Davids, Glen Rock, criminal justice; Megan Deardorff, Dover, behavioral science; Devon Dellinger, York, nursing; Robert Denoncourt, Yoe, management with honors; Nathan DeRose, Stewartstown, professional writing with honors; Jesse Diehl, York, chemistry; Alicia, Dietz, Etters, nursing; Nicholas, Dowd, Stewartstown, secondary education-biology with honors; Lacy Dubbs, Gettysburg, early elementary/special education with high honors; Krista Ducommun, York, nursing; Margaret Eckles-Ray, York, political science; Brandon Fairchild, York, management; Katelynn Fauth, York, behavioral science; Brittany Fishel, York, early elementary education with high honors; Ryan Forgione, Stewartstown, philosophy; Gail Franey, Littlestown, business administration; Michael Gable, York, marketing; Marlene Galante, New Freedom, business administration; Kristen Gardiner, York, criminal justice; Bruce Gemmill, Dallastown, secondary education-social studies and history; Kyle Gillespie, Shrewsbury, history; Monica Gingrow, York, early elementary education; Ryan Gladfelter, Dover, nursing; Matthew Gladfelter, Codorus Township, mechanical engineering; Paul Glassmoyer, York, criminal justice with high honors; Lindsay Godfrey, Felton, nursing; Sherry Golzari, Dallastown, nursing; Caryn Goodhart, Spring Grove, business administration; Jessica Graves, Stewartstown, nursing; Laura Greene, Chanceford Township, nursing with high honors; Abby Groft, Hanover, nursing; Taylor Gunder, Red Lion, engineering management; Amber Haar, East Berlin, behavioral science; Drew Harlacher, Dover, mechanical engineering with honors; Joshua Harris, Hanover, history; Leigh Heist, York, behavioral science; David Hoffmann, York, business administration; Kelsey, Holden, New Freedom, early elementary education; Erin Hudson, York, biology; Zachary, Huff, Hanover, secondary education-mathematics; Heather Hughes, Windsor, nursing; Emily Jannotta, Hanover, marketing; Richard Janosky, Dover, chemistry; Courtney Johnson, Stewartstown, speech/communications; Tyler Kauffman, Spring Grove, political science; Beverly Keiser, Codorus Township, information systems/development; Shelley Kern, York, history; Aaron Kikola, Felton, history; William Klinedinst, York, professional writing; Robert Krebs, York, early elementary/special education with high honors; Andrew Kuhl, New Freedom, political science; Elisa Laughman, New Oxford, nursing; Alek Leiphart, Red Lion, history with honors; Amber Lindt, Dover, psychology with honors; Ryan Livingston, York, accounting; Brittany MacFadden, New Freedom, nursing; Todd, Maciejewski, Red Lion, recreation and leisure administration; Cynthia Maradiaga, York, early elementary education with honors; Nicole Marchio, New Freedom, early elementary education with honors; Jeanette Mares, New Oxford, management; Casey Maschke, York, nursing; Brianna McCabe, Red Lion, secondary education-English with honors; Jason McClellan, York, music; April Melato, Lower Chanceford Township, secondary education-social studies and history; Lindsay Miller, York, graphic design; Morgan Miller, Biglerville, nursing; Diana Moore, Glen Rock, English literary studies with honors; Latisha, Murray, York, history; Aaron, Neff, Hallam, criminal justice; Victoria Newton, Stewartstown, international relations; Megan Noll, Abbottstown, early elementary education; Danielle Nusbaum, Manchester, nursing; Chelsea Owens, York, finance; Emily Pauly, York, business administration; Rafael Perez, York, biology with honors; Nicholas, Pier, York, computer information systems with highest honors; Emily Platts, Mount Wolf, political science; Rachael Polan, York, nursing with honors; Yann Potier, York, supply chain operations management; John Preis, York, history; Kayla Pucillo, Red Lion, nursing with high honors; Jennifer Rausch, York, early elementary/special education with high honors; Carrie Reall, Shrewsbury, biology; Renee Reeb-Fohl, York, nursing; Ashley Rineman, Hanover, nursing; Dycelie Rivera, York, business administration; Brian Roby, Stewartstown, criminal justice; Jacob Roupe, Fawn Grove, sport management; Nikki Santivasci, Glen Rock, history with high honors; Ashton Severns, York, computer information systems with honors; Danielle Shapiro, York, nuclear medicine technology; Taylor Shenberger, York, Spanish with highest honors; Katelyn Shutt, Dover, nursing with honors; Laura Slagle, York, business administration; Victoria Smith, East Berlin, history; Kyle Smith, Windsor, graphic design; Crystal Smith, Hanover, nursing; Alexis Snell, York, early elementary education with high honors; Antoinette Snyder, Manchester, psychology; Nathan Staub, York, nursing; Heather Stump, Windsor, nursing; Holly Tillman, Stewartstown, graphic design; Kelsey Toscano, Chanceford Township, nursing; Alix Unwin, York, psychology with honors; Maxleen Valentin-Rodriguez, York, early elementary/special education with high honors; Michael Vause, York, business administration; Stephanie Voshell, York, nursing; Luke Walker, Dallastown, political science; Tianna Weaver, Spring Grove, criminal justice with honors; Justin Webb, New Freedom, graphic design; Tuesday Wilson, Hellam Township, nursing; James Woof, York, sociology and Lauren Zortman, Red Lion, early elementary education with high honors.

Timothy Beckley, York; Derek Bennett, New Freedom; Emmett Butler, York; Chu Cong, York; Guy Copenheaver, Spring Grove; Michael Feight, Dover; Stacie Gross, York; Zachary Grove, Dover; Lindsay Hamilton, Etters; Shawn Hawk, York; Abby Keefer, East Berlin; James Laughlin, Hanover; Daniel Leiphart, York; Aimee Miller, East Berlin; Eric Minor, Fawn Township; Haydn Morris, York; Nakesha Muldrow, York; Daniel Pritchett, Yoe; Mark Renoll, York; Philip See, Manchester and Eric Wolfgang, York.

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York College December 2013 graduates

Brittle-bone babies helped by fetal stem cell grafts

PUBLIC RELEASE DATE:

16-Dec-2013

Contact: Press Office pressinfo@ki.se 46-852-486-077 Karolinska Institutet

Osteogeneis imperfecta (OI) is a congenital bone disease that causes stunted growth and repeated, painful fracturing. Ultrasound scans can reveal fractures already in the fetus, and now an international team of researchers from Sweden, Singapore and Taiwan have treated two babies in utero by injecting bone-forming stem cells. The longitudinal results of the treatment are published in the journal Stem Cells Translational Medicine.

The babies were treated with mesenchymal stem cells, connective tissue cells that can form and improve bone tissue. The stem cells were extracted from the livers of donors and although they were completely unmatched genetically, there was no rejection and the transplanted cells were accepted as self.

Back in 2005, a paper was published from Karolinska Institutet in Sweden describing how stem cells were given to a female fetus. The present study describes how the girl suffered a large number of fractures and developed scoliosis up to the age of eight, whereupon the researchers decided to give her a fresh stem cell graft from the same donor. For the next two years the girl suffered no new fractures and improved her growth rate. Today she takes dance lessons and participates more in PE at school.

Another unborn baby with OI, a girl from Taiwan, was also given stem cell transplantation by the Karolinska Institutet team and their colleagues from Singapore. The girl subsequently followed a normal and fracture-free growth trajectory until the age of one, when it levelled off. She was given a fresh stem cell treatment and her growth resumed. The girl started to walk and has since not suffered any new fractures. Today she is four years old.

"We believe that the stem cells have helped to relieve the disease since none of the children broke bones for a period following the grafts, and both increased their growth rate," says study leader Dr Cecilia Gtherstrm, researcher at Karolinska Institutet's Department of Clinical Sciences, Intervention and Technology. "Today, the children are doing much better than if the transplantations had not been given. OI is a very rare disease and lacks effective treatment, and a combined international effort is needed to examine whether stem cell grafts can alleviate the disease."

The researchers have also identified a patient, a boy from Canada, who was born with OI caused by exactly the same mutation as the Swedish girl had. The boy was not given stem cell therapy and was born with severe and widespread bone damage, including numerous fractures and kyphosis of the thoracic vertebrae, which causes such over-curvature of the spine that it impairs breathing. The boy died of pneumonia within his first 5 months.

Participating institutions in Singapore have been the National University Hospotal, and the KK Women's and Children's Hospital. Collaborating partner of Taiwan was the Chang Gung Memorial Hospital in Linkou. Researchers of several universities and hospitals in Sweden, Canada and the USA also took part in the work. The study was financed with a grant from the Swedish Society for Medical Research, and two of the participating researchers received a salary from the Singaporean Ministry of Health.

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Brittle-bone babies helped by fetal stem cell grafts